                               SEQUENCE LISTING

<110> NORTHWESTERN UNIVERSITY
      MANNIN RESEARCH, INC.
 
<120> CHIMERIC FUSIONS BETWEEN C4-BINDING PROTEIN C-TERMINAL SEGMENT 
      AND ANGIOPOIETIN-1 FIBRINOGEN-LIKE DOMAIN AS ANGIOPOIETIN 
      MIMETICS AND TIE2 AGONISTS TO TREAT VASCULAR DISEASES

<130> 14002.6006-00134

<140>
<141>

<150> 62/983,328
<151> 2020-02-28

<160> 36    

<170> PatentIn version 3.5

<210> 1
<211> 57
<212> PRT
<213> Homo sapiens

<400> 1
Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210> 2
<211> 218
<212> PRT
<213> Homo sapiens

<400> 2
Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
1               5                   10                  15      


Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
            20                  25                  30          


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln 
        35                  40                  45              


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
                85                  90                  95      


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
            100                 105                 110         


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
145                 150                 155                 160 


Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn 
            180                 185                 190         


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Leu Asp Phe 
    210                 215             


<210> 3
<211> 218
<212> PRT
<213> Homo sapiens

<400> 3
Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr 
1               5                   10                  15      


Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Gly Gly Gly Gly Ser 
1               5   


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Asp Asp Asp Asp Lys 
1               5   


<210> 8
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
1               5                   10                  15      


Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
            20                  25                  30          


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln 
        35                  40                  45              


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
                85                  90                  95      


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
            100                 105                 110         


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
145                 150                 155                 160 


Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn 
            180                 185                 190         


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Leu Asp Phe Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 


Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln 
225                 230                 235                 240 


Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys 
                245                 250                 255     


Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg 
            260                 265                 270         


Gln Ser Thr Leu Asp Lys Glu Leu His His His His His His 
        275                 280                 285     


<210> 9
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala 
            20                  25                  30          


Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro 
        35                  40                  45              


Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp 
    50                  55                  60                  


Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly 
65                  70                  75                  80  


Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp 
                85                  90                  95      


Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met 
            100                 105                 110         


Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln 
        115                 120                 125             


Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr 
    130                 135                 140                 


Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu 
145                 150                 155                 160 


His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met 
                165                 170                 175     


Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys 
            180                 185                 190         


Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His 
        195                 200                 205             


Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr 
    210                 215                 220                 


Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys 
                245                 250                 255     


Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu 
            260                 265                 270         


Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg 
        275                 280                 285             


Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu His His His His 
    290                 295                 300                 


His His 
305     


<210> 10
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Lys Pro 
    50                  55                  60                  


Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly 
65                  70                  75                  80  


Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val Phe 
                85                  90                  95      


Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His Arg 
            100                 105                 110         


Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met 
        115                 120                 125             


Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile 
    130                 135                 140                 


Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu Met 
145                 150                 155                 160 


Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile 
                165                 170                 175     


Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly 
            180                 185                 190         


Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe Ser 
        195                 200                 205             


Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu Met 
    210                 215                 220                 


Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn 
225                 230                 235                 240 


Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly Ile 
                245                 250                 255     


Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr 
            260                 265                 270         


Met Met Ile Arg Pro Leu Asp Phe His His His His His His 
        275                 280                 285     


<210> 11
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly 
            20                  25                  30          


Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala 
        35                  40                  45              


Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln 
    50                  55                  60                  


Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe 
                85                  90                  95      


Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro 
            100                 105                 110         


Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val 
        115                 120                 125             


Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys 
    130                 135                 140                 


Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly 
145                 150                 155                 160 


Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg 
                165                 170                 175     


Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp 
            180                 185                 190         


Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys 
        195                 200                 205             


Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly 
    210                 215                 220                 


Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys 
225                 230                 235                 240 


Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro 
                245                 250                 255     


Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys 
            260                 265                 270         


Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu 
        275                 280                 285             


Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe His His His His 
    290                 295                 300                 


His His 
305     


<210> 12
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Ile Ser 
    50                  55                  60                  


Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala Tyr 
                85                  90                  95      


Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg Arg 
            100                 105                 110         


Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys Val 
        115                 120                 125             


Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Val 
    130                 135                 140                 


Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu Lys 
145                 150                 155                 160 


Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr Leu 
                165                 170                 175     


Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr Gly 
            180                 185                 190         


Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe Ser 
        195                 200                 205             


Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln Met 
    210                 215                 220                 


Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn 
225                 230                 235                 240 


Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn Gly Ile 
                245                 250                 255     


Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr Thr 
            260                 265                 270         


Met Met Ile Arg Pro Ala Asp Phe His His His His His His 
        275                 280                 285     


<210> 13
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly 
            20                  25                  30          


Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala 
        35                  40                  45              


Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln 
    50                  55                  60                  


Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His 
                85                  90                  95      


Thr Thr Asn Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu 
            100                 105                 110         


Ile Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile 
        115                 120                 125             


Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys 
    130                 135                 140                 


Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly 
145                 150                 155                 160 


Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys 
                165                 170                 175     


Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu 
            180                 185                 190         


His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys 
        195                 200                 205             


Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly 
    210                 215                 220                 


Asn Asp Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys 
225                 230                 235                 240 


Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro 
                245                 250                 255     


Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys 
            260                 265                 270         


Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu 
        275                 280                 285             


Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe His His His His 
    290                 295                 300                 


His His 
305     


<210> 14
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
His His His His His His Gly Asp Asp Asp Asp Lys Lys Pro Phe Arg 
1               5                   10                  15      


Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr 
            20                  25                  30          


Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn 
        35                  40                  45              


Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp 
    50                  55                  60                  


Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe 
65                  70                  75                  80  


Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala 
                85                  90                  95      


Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp 
            100                 105                 110         


Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn 
        115                 120                 125             


Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala 
    130                 135                 140                 


Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys 
145                 150                 155                 160 


Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr 
                165                 170                 175     


Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met 
            180                 185                 190         


Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp 
        195                 200                 205             


His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met 
    210                 215                 220                 


Ile Arg Pro Leu Asp Phe Gly Gly Gly Gly Ser Glu Thr Pro Glu Gly 
225                 230                 235                 240 


Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn 
                245                 250                 255     


Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu 
            260                 265                 270         


Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu 
        275                 280                 285             


Asp Lys Glu Leu 
    290         


<210> 15
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu His His His His His His Gly Asp Asp Asp Asp 
            20                  25                  30          


Lys Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn 
        35                  40                  45              


Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys 
    50                  55                  60                  


Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile 
65                  70                  75                  80  


Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu 
                85                  90                  95      


Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn 
            100                 105                 110         


Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile 
        115                 120                 125             


Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg 
    130                 135                 140                 


Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly 
145                 150                 155                 160 


His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala 
                165                 170                 175     


Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys 
            180                 185                 190         


Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser 
        195                 200                 205             


Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu 
    210                 215                 220                 


Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg 
225                 230                 235                 240 


Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
            260                 265                 270         


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
        275                 280                 285             


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
    290                 295                 300                 


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
305                 310             


<210> 16
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
His His His His His His Gly Gly Asp Asp Asp Asp Lys Glu Thr Pro 
1               5                   10                  15      


Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
            20                  25                  30          


Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser 
        35                  40                  45              


Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser 
    50                  55                  60                  


Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Lys Pro Phe Arg Asp 
65                  70                  75                  80  


Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr 
                85                  90                  95      


Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val Phe Cys Asn Met 
            100                 105                 110         


Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly 
        115                 120                 125             


Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly 
    130                 135                 140                 


Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile 
145                 150                 155                 160 


Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu Met Asp Trp Glu 
                165                 170                 175     


Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile Gly Asn Glu 
            180                 185                 190         


Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly Thr Ala Gly 
        195                 200                 205             


Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe Ser Thr Lys Asp 
    210                 215                 220                 


Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu Met Leu Thr Gly 
225                 230                 235                 240 


Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn Gly Met Phe 
                245                 250                 255     


Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly Ile Lys Trp His 
            260                 265                 270         


Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr Met Met Ile 
        275                 280                 285             


Arg Pro Leu Asp Phe 
    290             


<210> 17
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu His His His His His His Gly Gly Asp Asp Asp 
            20                  25                  30          


Asp Lys Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg 
        35                  40                  45              


Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu 
    50                  55                  60                  


Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp 
65                  70                  75                  80  


Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser 
                85                  90                  95      


Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys 
            100                 105                 110         


Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys 
        115                 120                 125             


Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln 
    130                 135                 140                 


His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr 
145                 150                 155                 160 


Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
                165                 170                 175     


Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu 
            180                 185                 190         


Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe 
        195                 200                 205             


His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His 
    210                 215                 220                 


Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp 
225                 230                 235                 240 


Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala 
                245                 250                 255     


Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
            260                 265                 270         


Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn 
        275                 280                 285             


Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser 
    290                 295                 300                 


Thr Thr Met Met Ile Arg Pro Leu Asp Phe 
305                 310                 


<210> 18
<211> 274
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln 
            20                  25                  30          


Ala Gly Phe Asn Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met 
        35                  40                  45              


Pro Glu Pro Lys Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly 
    50                  55                  60                  


Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg 
65                  70                  75                  80  


Gly Trp Lys Glu Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
                85                  90                  95      


Trp Leu Gly Asn Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr 
            100                 105                 110         


Met Leu Arg Ile Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser 
        115                 120                 125             


Gln Tyr Asp Arg Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu 
    130                 135                 140                 


Tyr Leu Lys Gly His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile 
145                 150                 155                 160 


Leu His Gly Ala Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys 
                165                 170                 175     


Met Cys Lys Cys Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala 
            180                 185                 190         


Cys Gly Pro Ser Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn 
        195                 200                 205             


His Gly Lys Leu Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser 
    210                 215                 220                 


Tyr Ser Leu Arg Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly 
                245                 250                 255     


Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala 
            260                 265                 270         


Leu Glu 
        


<210> 19
<211> 302
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
            20                  25                  30          


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
        35                  40                  45              


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
    50                  55                  60                  


Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Lys Pro 
65                  70                  75                  80  


Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly 
                85                  90                  95      


Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val Phe 
            100                 105                 110         


Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His Arg 
        115                 120                 125             


Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met 
    130                 135                 140                 


Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile 
145                 150                 155                 160 


Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu Met 
                165                 170                 175     


Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile 
            180                 185                 190         


Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly 
        195                 200                 205             


Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe Ser 
    210                 215                 220                 


Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu Met 
225                 230                 235                 240 


Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn 
                245                 250                 255     


Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly Ile 
            260                 265                 270         


Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr 
        275                 280                 285             


Met Met Ile Arg Pro Leu Asp Phe His His His His His His 
    290                 295                 300         


<210> 20
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Glu Lys Pro Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn 
1               5                   10                  15      


Lys Ser Gly Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys 
            20                  25                  30          


Lys Val Phe Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile 
        35                  40                  45              


Gln His Arg Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu 
    50                  55                  60                  


Tyr Lys Met Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn 
65                  70                  75                  80  


Glu Phe Ile Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile 
                85                  90                  95      


Glu Leu Met Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg 
            100                 105                 110         


Phe His Ile Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly 
        115                 120                 125             


His Thr Gly Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala 
    130                 135                 140                 


Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys 
145                 150                 155                 160 


Ala Leu Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser 
                165                 170                 175     


Asn Leu Asn Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu 
            180                 185                 190         


Asn Gly Ile Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg 
        195                 200                 205             


Ser Thr Thr Met Met Ile Arg Pro Leu Asp Phe Gly Gly Gly Gly Ser 
    210                 215                 220                 


Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
225                 230                 235                 240 


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu 
                245                 250                 


<210> 21
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

aaaccattta gagactgtgc agatgtatat caagctggtt ttaataaaag tggaatctac      120

actatttata ttaataatat gccagaaccc aaaaaggtgt tttgcaatat ggatgtcaat      180

gggggaggtt ggactgtaat acaacatcgt gaagatggaa gtctagattt ccaaagaggc      240

tggaaggaat ataaaatggg ttttggaaat ccctccggtg aatattggct ggggaatgag      300

tttatttttg ccattaccag tcagaggcag tacatgctaa gaattgagtt aatggactgg      360

gaagggaacc gagcctattc acagtatgac agattccaca taggaaatga aaagcaaaac      420

tataggttgt atttaaaagg tcacactggg acagcaggaa aacagagcag cctgatctta      480

cacggtgctg atttcagcac taaagatgct gataatgaca actgtatgtg caaatgtgcc      540

ctcatgttaa caggaggatg gtggtttgat gcttgtggcc cctccaatct aaatggaatg      600

ttctatactg cgggacaaaa ccatggaaaa ctgaatggga taaagtggca ctacttcaaa      660

gggcccagtt actccttacg ttccacaact atgatgattc gacctttaga ttttggtggc      720

ggtggctcag agacccccga aggctgtgaa caagtgctca caggcaaaag actcatgcag      780

tgtctcccaa acccagagga tgtgaaaatg gccctggagg tatataagct gtctctggaa      840

attgaacaac tggaactaca aagggacagc gcaagacaat ccactttgga taaagaacta      900

catcaccatc accatcacta a                                                921


<210> 22
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
atgtacagaa tgcagctgct gtcctgtatc gccctgagcc tggctctggt gaccaactct       60

gagacaccag agggatgtga gcaggtgctg accggcaagc gcctgatgca gtgcctgccc      120

aatcctgagg atgtgaagat ggccctggag gtgtacaagc tgtccctgga gatcgagcag      180

ctggagctgc agagggattc cgcccggcag tctacactgg acaaggagct gggaggagga      240

ggcagcaagc ctttcaggga ttgtgccgac gtgtatcagg ctggctttaa caagtctggc      300

atctacacca tctatatcaa caatatgcca gagcccaaga aggtgttctg caacatggac      360

gtgaatggcg gcggctggac agtgatccag cacagggagg atggcagcct ggacttccag      420

cggggctgga aggagtacaa gatgggcttt ggcaacccat ctggcgagta ttggctgggc      480

aatgagttca tctttgccat cacctcccag agacagtaca tgctgcgcat cgagctgatg      540

gattgggagg gcaatagggc ttactctcag tatgaccggt tccatatcgg caacgagaag      600

cagaattacc ggctgtatct gaagggacac accggaacag ctggcaagca gtccagcctg      660

atcctgcatg gcgccgattt ttccaccaag gacgctgata acgacaattg catgtgcaag      720

tgcgccctga tgctgacagg aggatggtgg ttcgacgctt gcggaccaag caacctgaat      780

ggcatgtttt atacagctgg ccagaaccac ggcaagctga atggcatcaa gtggcattac      840

ttcaagggcc cttcttattc cctgagatcc accacaatga tgatccgccc actggatttt      900

caccatcacc atcaccatta a                                                921


<210> 23
<211> 909
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atgcctctgc tgctgctgct gccactgctg tgggctggcg ctctggccga gacaccagag       60

ggctgtgagc aggtgctgac aggcaagaga ctgatgcagt gcctgcccaa ccctgaggat      120

gtgaagatgg ctctggaggt gtacaagctg tctctggaga tcgagcagct ggagctgcag      180

agggatagcg cccggcagtc taccctggac aaggagctgg gaggaggagg ctctaagccc      240

ttccgcgatt gtgctgacgt gtatcaggcc ggctttaata agtccggcat ctacaccatc      300

tatatcaaca atatgccaga gcccaagaag gtgttctgca acatggacgt gaatggcggc      360

ggctggacag tgatccagca cagggaggat ggctccctgg acttccagcg gggctggaag      420

gagtacaaga tgggctttgg caacccttcc ggcgagtatt ggctgggcaa tgagttcatc      480

tttgctatca caagccagag acagtacatg ctgcgcatcg agctgatgga ttgggagggc      540

aacagggcct acagccagta tgaccggttc catatcggca acgagaagca gaattacagg      600

ctgtatctga agggccacac cggcacagct ggcaagcagt ccagcctgat cctgcatggc      660

gctgacttct ccaccaagga cgccgataac gacaattgca tgtgcaagtg cgctctgatg      720

ctgacaggag gatggtggtt cgacgcttgt ggaccatcta acctgaatgg catgttttat      780

accgccggcc agaaccacgg caagctgaat ggcatcaagt ggcattactt caagggcccc      840

tcttattccc tgagatccac cacaatgatg atccgccctc tggattttca ccatcaccat      900

caccattaa                                                              909


<210> 24
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
atgtacagaa tgcagctgct gagctgtatc gccctgtctc tggctctggt gaccaactct       60

gagacaccag agggctgtga gcaggtgctg accggcaagc gcctgatgca gtgcctgccc      120

aatcctgagg atgtgaagat ggccctggag gtgtataagc tgtccctgga gatcgagcag      180

ctggagctgc agagagattc tgctcgccag tccaccctgg acaaggagct gggaggagga      240

ggcagcatct ctttcagaga ttgtgccgag gtgtttaaga gcggccacac cacaaacggc      300

atctacaccc tgacattccc taattctaca gaggagatca aggcctattg cgacatggag      360

gctggaggag gaggatggac catcatccag aggcgggagg atggcagcgt ggacttccag      420

aggacatgga aggagtacaa agtgggcttt ggcaacccat ctggcgagta ttggctgggc      480

aacgagttcg tgtcccagct gaccaatcag cagcggtacg tgctgaagat ccatctgaag      540

gattgggagg gcaacgaggc ctactctctg tatgagcact tttacctgtc cagcgaggag      600

ctgaattatc gcatccatct gaagggcctg accggcacag ctggcaagat ctcttccatc      660

tcccagcccg gcaacgattt cagcaccaag gacggcgata atgacaagtg catctgtaag      720

tgctcccaga tgctgacagg aggatggtgg ttcgacgctt gcggaccaag caacctgaat      780

ggcatgtact atccccagag gcagaacaca aataagttta atggcatcaa gtggtactat      840

tggaagggct ccggctatag cctgaaggcc accacaatga tgatccggcc tgctgacttt      900

caccatcacc atcaccatta a                                                921


<210> 25
<211> 942
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
atgtacagaa tgcagctgct gtcctgtatc gccctgagcc tggctctggt gaccaactct       60

gagcaccatc accatcacca tggcgacgat gacgataaga agccattccg cgattgtgcc      120

gacgtgtatc aggctggctt taataagtcc ggcatctaca ccatctatat caacaatatg      180

cccgagccta agaaggtgtt ctgcaacatg gatgtgaatg gcggcggctg gacagtgatc      240

cagcacaggg aggatggcag cctggacttc cagcggggct ggaaggagta caagatgggc      300

tttggcaacc cctctggcga gtattggctg ggcaatgagt tcatctttgc catcacatcc      360

cagagacagt acatgctgcg catcgagctg atggattggg agggcaacag ggcttactct      420

cagtatgacc ggttccatat cggcaacgag aagcagaatt acaggctgta tctgaaggga      480

cacaccggaa cagctggcaa gcagtccagc ctgatcctgc atggcgccga tttttccacc      540

aaggacgctg ataacgacaa ttgcatgtgc aagtgcgccc tgatgctgac aggaggatgg      600

tggttcgacg cttgcggacc aagcaacctg aatggcatgt tttacaccgc tggccagaac      660

cacggcaagc tgaatggcat caagtggcat tacttcaagg gcccttctta ttccctgaga      720

agcaccacaa tgatgatcag gcctctggat tttggaggag gaggctctga gacaccagag      780

ggatgtgagc aggtgctgac aggcaagcgg ctgatgcagt gcctgccaaa tcccgaggac      840

gtgaagatgg ccctggaggt gtataagctg tccctggaga tcgagcagct ggagctgcag      900

agggattccg cccggcagtc tacactggac aaggagctgt aa                         942


<210> 26
<211> 945
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
atgtacagaa tgcagctgct gtcctgtatc gccctgagcc tggctctggt gaccaactct       60

gagcaccatc accatcacca tggcggcgac gatgacgata aggagacacc cgagggctgt      120

gagcaggtgc tgacaggcaa gcgcctgatg cagtgcctgc ccaatcctga ggatgtgaag      180

atggccctgg aggtgtacaa gctgtccctg gagatcgagc agctggagct gcagagggat      240

tccgcccggc agtctacact ggacaaggag ctgggaggag gaggcagcaa gcctttcagg      300

gattgtgccg acgtgtatca ggctggcttt aacaagtctg gcatctacac catctatatc      360

aacaatatgc cagagcccaa gaaggtgttc tgcaacatgg acgtgaatgg cggcggctgg      420

acagtgatcc agcacaggga ggatggcagc ctggacttcc agcggggctg gaaggagtac      480

aagatgggct ttggcaaccc atctggcgag tattggctgg gcaatgagtt catctttgcc      540

atcacctccc agagacagta catgctgcgc atcgagctga tggattggga gggcaatagg      600

gcttactctc agtatgaccg gttccatatc ggcaacgaga agcagaatta ccggctgtat      660

ctgaagggac acaccggaac agctggcaag cagtccagcc tgatcctgca tggcgccgat      720

ttttccacca aggacgctga taacgacaat tgcatgtgca agtgcgccct gatgctgaca      780

ggaggatggt ggttcgacgc ttgcggacca agcaacctga atggcatgtt ttatacagct      840

ggccagaacc acggcaagct gaatggcatc aagtggcatt acttcaaggg cccttcttat      900

tccctgagat ccaccacaat gatgatccgc ccactggatt tttaa                      945


<210> 27
<211> 906
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 27
atgtacagaa tgcagctgct gtcctgtatc gccctgagcc tggctctggt gaccaactct       60

gagaagccat tccgcgattg tgccgacgtg tatcaggctg gctttaataa gtccggcatc      120

tacaccatct atatcaacaa tatgcccgag cctaagaagg tgttctgcaa catggatgtg      180

aatggcggcg gctggacagt gatccagcac agggaggatg gcagcctgga cttccagcgg      240

ggctggaagg agtacaagat gggctttggc aacccctctg gcgagtattg gctgggcaat      300

gagttcatct ttgccatcac atcccagaga cagtacatgc tgcgcatcga gctgatggat      360

tgggagggca acagggctta ctctcagtat gaccggttcc atatcggcaa cgagaagcag      420

aattacaggc tgtatctgaa gggacacacc ggaacagctg gcaagcagtc cagcctgatc      480

ctgcatggcg ccgatttttc caccaaggac gctgataacg acaattgcat gtgcaagtgc      540

gccctgatgc tgacaggagg atggtggttc gacgcttgcg gaccaagcaa cctgaatggc      600

atgttttaca ccgctggcca gaaccacggc aagctgaatg gcatcaagtg gcattacttc      660

aagggccctt cttattccct gagaagcacc acaatgatga tcaggcctct ggattttgga      720

ggaggaggct ctgagacacc agagggatgt gagcaggtgc tgacaggcaa gcggctgatg      780

cagtgcctgc caaatcccga ggacgtgaag atggccctgg aggtgtataa gctgtccctg      840

gagatcgagc agctggagct gcagagggat tccgcccggc agtctacact ggacaaggag      900

ctgtaa                                                                 906


<210> 28
<211> 280
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Lys Pro 
    50                  55                  60                  


Phe Arg Asp Cys Ala Asp Val Tyr Gln Ala Gly Phe Asn Lys Ser Gly 
65                  70                  75                  80  


Ile Tyr Thr Ile Tyr Ile Asn Asn Met Pro Glu Pro Lys Lys Val Phe 
                85                  90                  95      


Cys Asn Met Asp Val Asn Gly Gly Gly Trp Thr Val Ile Gln His Arg 
            100                 105                 110         


Glu Asp Gly Ser Leu Asp Phe Gln Arg Gly Trp Lys Glu Tyr Lys Met 
        115                 120                 125             


Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Ile 
    130                 135                 140                 


Phe Ala Ile Thr Ser Gln Arg Gln Tyr Met Leu Arg Ile Glu Leu Met 
145                 150                 155                 160 


Asp Trp Glu Gly Asn Arg Ala Tyr Ser Gln Tyr Asp Arg Phe His Ile 
                165                 170                 175     


Gly Asn Glu Lys Gln Asn Tyr Arg Leu Tyr Leu Lys Gly His Thr Gly 
            180                 185                 190         


Thr Ala Gly Lys Gln Ser Ser Leu Ile Leu His Gly Ala Asp Phe Ser 
        195                 200                 205             


Thr Lys Asp Ala Asp Asn Asp Asn Cys Met Cys Lys Cys Ala Leu Met 
    210                 215                 220                 


Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn 
225                 230                 235                 240 


Gly Met Phe Tyr Thr Ala Gly Gln Asn His Gly Lys Leu Asn Gly Ile 
                245                 250                 255     


Lys Trp His Tyr Phe Lys Gly Pro Ser Tyr Ser Leu Arg Ser Thr Thr 
            260                 265                 270         


Met Met Ile Arg Pro Leu Asp Phe 
        275                 280 


<210> 29
<211> 280
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu Gly Gly Gly Gly Ser Ile Ser 
    50                  55                  60                  


Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn Gly 
65                  70                  75                  80  


Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala Tyr 
                85                  90                  95      


Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg Arg 
            100                 105                 110         


Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys Val 
        115                 120                 125             


Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe Val 
    130                 135                 140                 


Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu Lys 
145                 150                 155                 160 


Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr Leu 
                165                 170                 175     


Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr Gly 
            180                 185                 190         


Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe Ser 
        195                 200                 205             


Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln Met 
    210                 215                 220                 


Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu Asn 
225                 230                 235                 240 


Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn Gly Ile 
                245                 250                 255     


Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr Thr 
            260                 265                 270         


Met Met Ile Arg Pro Ala Asp Phe 
        275                 280 


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 30
His His His His His His 
1               5       


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Gly Gly Gly Ser 
1               


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Glu Ala Ala Ala Lys 
1               5   


<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Pro Ala Pro Ala Pro 
1               5   


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210> 35
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


