                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  PBP3 BINDING BICYCLIC PEPTIDE LIGANDS

<130>  BIC-C-P2763PCT

<150>  2002706.6
<151>  2020-02-26

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  1

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  2

Cys Arg Thr Phe Gly Cys Trp Trp Glu Gly Cys 
1               5                   10      


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  3

Cys Leu Glu Asn Cys Tyr Tyr Val Pro Tyr Tyr Gly Tyr Ala Cys 
1               5                   10                  15  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is K(Ac)

<400>  4

Cys Ser Phe Pro Xaa Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  5

Cys Tyr Phe Pro Gly Cys Pro Trp Val Glu Asn Cys 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  6

Cys Gln Phe Pro Val Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  7

Cys Ser Phe Pro Met Cys Pro Trp Val Glu Asn Cys 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  8

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu Lys Cys 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  9

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu Ala Cys 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is 2Nal

<400>  10

Cys Ser Phe Pro Lys Cys Pro Xaa Val Glu Gly Cys 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is 1Nal

<400>  11

Cys Ser Phe Pro Lys Cys Pro Xaa Val Glu Gly Cys 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is HArg

<400>  12

Cys Ser Phe Pro Xaa Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  13

Cys Ala Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  14

Cys Ser Ala Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  15

Cys Ser Phe Ala Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  16

Cys Ser Phe Pro Ala Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  17

Cys Ser Phe Pro Lys Cys Ala Trp Val Glu Gly Cys 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  18

Cys Ser Phe Pro Lys Cys Pro Trp Val Ala Gly Cys 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  19

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu Ala Cys 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  20

Cys Lys Phe Pro Val Cys Pro Trp Val Glu Tyr Cys 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  21

Cys His Phe Pro Thr Cys Pro Trp Val Glu Trp Cys 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  22

Cys Thr Phe Pro Ala Cys Pro Trp Val Glu Tyr Cys 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  23

Cys Leu Phe Pro Gly Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  24

Cys Phe Phe Pro Gln Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  25

Cys His Phe Pro Val Cys Pro Trp Val Glu Asn Cys 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  26

Cys His Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  27

Cys Glu Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  28

Cys Tyr Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  29

Cys Ser Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  30

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  31

Cys Thr Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  32

Cys Ser Phe Pro Lys Cys Pro Trp Val Glu Asn Cys 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  33

Cys Trp Phe Pro Asn Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  34

Cys Tyr Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  35

Cys Arg Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  36

Cys Ser Phe Pro Ile Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  37

Cys Val Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  38

Cys Ile Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  39

Cys Ser Phe Ala Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  40

Cys Ser Phe Pro Ala Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  41

Cys Ser Phe Pro Thr Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  42

Cys Val Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  43

Cys Ser Phe Pro His Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  44

Cys His Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  45

Cys Glu Tyr Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  46

Cys Ser Phe Pro Leu Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  47

Cys Ala Phe Pro His Cys Pro Trp Val Glu Phe Cys 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  48

Cys Gln Phe Pro Gly Cys Pro Trp Val Glu Phe Cys 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  49

Cys Ile Phe Pro Lys Cys Pro Trp Val Glu Gly Cys 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  50

Cys Ser Phe Pro Ser Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  51

Cys Trp Phe Pro Gly Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  52

Cys Arg Phe Pro Asp Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  53

Cys His Phe Pro Thr Cys Pro Trp Val Glu Tyr Cys 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  54

Cys Val Phe Pro Ala Cys Pro Trp Val Glu Tyr Cys 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  55

Cys Asn Phe Pro Glu Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  56

Cys Arg Phe Pro Asn Cys Pro Trp Val Glu His Cys 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  57

Cys Val Phe Pro Thr Cys Pro Trp Val Glu His Cys 
1               5                   10          


