                         SEQUENCE LISTING

<110>  KATHOLIEKE UNIVERSITEIT LEUVEN
 
<120>  CORONAVIRUS VACCINES

<130>  LRD-075-PCT

<150>  GB 2002766.0
<151>  2020-02-27

<150>  GB 2010479.0
<151>  2020-08-07

<150>  GB 2013912.7
<151>  2020-09-04

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  3819
<212>  DNA
<213>  SARS-CoV-2

<400>  1
atgtttgttt tcttggtcct ccttccactg gtatcctcac aatgtgtgaa tcttaccacc       60

cgaacccagc ttcctcccgc ctacacgaat tcattcacgc ggggtgttta ttacccggat      120

aaagttttcc ggtccagtgt cctgcattca acccaagacc tctttctgcc atttttttct      180

aacgtgacgt ggttccatgc tatccatgta agcggaacca acggaaccaa acggttcgat      240

aatccggttc tcccattcaa cgatggggtt tacttcgcat ctacagaaaa atctaacata      300

attagaggat ggatttttgg gactacgctt gacagtaaga cccaatcact cttgatcgtg      360

aacaatgcaa ccaatgtagt aattaaggtt tgcgagtttc aattttgtaa tgatccattt      420

ttgggggttt attaccacaa aaacaataaa tcctggatgg aatccgaatt cagagtgtat      480

agcagcgcta acaattgcac atttgagtac gtgtcacaac cttttcttat ggatcttgag      540

ggcaagcaag ggaacttcaa aaatttgagg gagttcgttt tcaagaacat cgacggatac      600

tttaagatct attctaaaca cacccccatt aacttggtgc gagatttgcc tcaaggcttc      660

tctgcacttg aaccgttggt ggatcttccc attggcatta atattactcg gttccagact      720

ttgttggcac tgcatcgctc ctatctcacg cccggagaca gttcatctgg atggactgcg      780

ggggctgccg cgtattacgt gggatacctg cagccgcgca catttcttct taaatacaac      840

gagaacggga ccatcacaga tgcagtggat tgcgctcttg accccctctc cgaaacaaaa      900

tgtacgctca agtctttcac tgtagagaaa gggatttatc agacatccaa tttccgagtc      960

cagccaacag agagtatagt gcggttccct aacatcacaa atctttgtcc gttcggggaa     1020

gttttcaacg ctacacgctt cgcaagtgta tacgcttgga atagaaagag gatctctaat     1080

tgtgtggcag attactctgt gctctacaat tccgcatctt tctcaacctt caagtgttac     1140

ggagtttcac ctacgaagct gaacgacctt tgctttacta atgtatatgc agatagtttt     1200

gtcatcaggg gcgatgaagt tcgacagata gcgcccggcc agacaggaaa gatcgcggac     1260

tacaattata aactccctga tgatttcacc gggtgcgtga tcgcgtggaa ctctaataac     1320

ctcgactcca aagtaggcgg taactacaat tacttgtatc gattgtttag aaaatcaaac     1380

cttaaaccgt tcgagcggga tatctctacc gagatatacc aagcaggctc tacaccgtgc     1440

aatggagtcg aaggttttaa ctgctacttc cccttgcaat catacgggtt tcagcctacc     1500

aacggtgtag gataccagcc ttacagggtt gtggtacttt catttgagct cctgcacgct     1560

cccgcaactg tctgtgggcc caaaaagagc actaaccttg ttaaaaataa atgcgtcaac     1620

tttaacttca atggcctcac tggcaccggc gtgctcactg aaagcaataa gaaattcctt     1680

ccttttcagc agtttgggcg agacatagcg gataccacgg acgcagtacg ggatcctcaa     1740

acccttgaaa tccttgacat aacgccttgc tcttttgggg gagtaagcgt aatcacgcct     1800

ggaaccaaca cctccaatca ggttgctgtg ctgtaccagg atgtaaactg caccgaggta     1860

ccggtagcca ttcacgcgga tcagctgact cccacatggc gagtgtattc tacaggtagt     1920

aatgtgtttc agacccgagc agggtgtttg ataggggcgg agcacgtcaa caactcatac     1980

gagtgcgata tacccattgg ggctggtata tgtgcatcct accagacgca gacgaactct     2040

cctcgccgcg ctcggtctgt tgcatctcaa tcaattattg catacactat gtcactgggg     2100

gctgagaatt cagtagccta ctctaacaac agcatcgcga ttcccactaa cttcacaatt     2160

agtgtgacta ccgagatcct gccagtatcc atgactaaaa ctagcgtaga ttgtactatg     2220

tacatctgcg gcgattcaac tgagtgttca aacctcctct tgcaatacgg gtcattttgt     2280

acccaattga atcgagctct gaccggcatc gcggtcgaac aggacaaaaa tactcaagag     2340

gtatttgccc aggtgaagca gatttacaaa acacccccta tcaaggattt cgggggcttc     2400

aacttcagcc agatactgcc agacccctca aaaccgagca agcgctcctt catagaagat     2460

cttcttttca acaaagttac cctcgcggat gctggtttca ttaaacagta tggggactgt     2520

ctcggcgaca ttgctgctag agacctcatc tgcgcgcaaa agttcaatgg acttacggtc     2580

ctgccccctc tcctcactga tgaaatgatt gctcaatata cgtccgcgtt gttggcggga     2640

actataacca gtgggtggac gttcggcgct ggcgccgcgc ttcaaatccc atttgcgatg     2700

caaatggcgt atcgcttcaa cggcatcgga gtaactcaaa acgttctgta cgaaaatcaa     2760

aaactcattg cgaaccagtt taattcagcg atcggtaaaa tccaggacag cctgagctcc     2820

acagcgagtg cactcgggaa gctccaggat gtggtaaatc agaacgctca agcgttgaac     2880

acactcgtca agcagctgtc aagtaacttt ggcgcgattt catctgtatt gaatgacatt     2940

ctctctcgcc ttgataaggt ggaagccgaa gtccagattg atcgcctgat tactgggcgg     3000

cttcagtccc tccaaacata cgtcactcag caacttatta gagccgccga aattagggca     3060

agtgcgaatc tggccgcgac aaaaatgtct gaatgtgtgc tggggcagag caagagagtc     3120

gatttttgcg gtaaggggta tcaccttatg tcttttcctc agtctgcccc tcacggagta     3180

gtgtttctcc acgttacgta tgtcccagcc caagagaaaa actttaccac tgcgccggct     3240

atttgtcatg acggtaaagc acactttcca cgcgaaggtg tgttcgtctc caacggcacc     3300

cactggtttg taacgcagag gaacttctac gagcctcaga taattaccac ggacaacacg     3360

ttcgtctcag gtaactgcga cgtcgtaatt ggtattgtaa ataacaccgt gtacgacccg     3420

ctccagccgg agctggactc cttcaaagag gagcttgaca agtattttaa gaatcacact     3480

tcaccggatg tagacctggg ggatatttcc ggcataaacg cttccgtggt taacatacag     3540

aaagagatag atcgactgaa cgaggtagcg aaaaacttga atgagtcttt gatagacctg     3600

caagaattgg gaaaatatga acaatatatt aagtggccct ggtatatttg gcttggtttc     3660

atagccggtt tgattgccat cgtcatggta actataatgc tttgttgcat gacaagttgc     3720

tgctcttgcc tcaaagggtg ctgctcctgt ggaagttgtt gcaagttcga tgaggatgat     3780

tctgagccag tgcttaaggg tgtcaaactg cattatacg                            3819


<210>  2
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  4182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct 1

<400>  3
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      840

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      900

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      960

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag     1020

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag     1080

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1140

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1200

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1260

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1320

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1380

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1440

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1500

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1560

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1620

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1680

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1740

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1800

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1860

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1920

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1980

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     2040

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     2100

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tcgccgcgct     2160

cggtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2220

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2280

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2340

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2400

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2460

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2520

atactgccag acccctcaaa accgagcaag cgctccttca tagaagatct tcttttcaac     2580

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2640

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2700

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2760

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2820

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2880

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2940

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     3000

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     3060

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3120

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3180

gccgcgacaa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3240

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3300

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3360

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3420

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3480

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3540

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3600

gacctggggg atatttccgg cataaacgct tccgtggtta acatacagaa agagatagat     3660

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3720

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3780

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3840

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3900

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3960

ggagttttgc tcttcctttc ggtcaacgtc catgctgatc aaggatgcgc catcaacttt     4020

ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc tgatgactgg     4080

ctgaacaagt actcatacta tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc     4140

tcttttgaag aagggaagtg tggcctaaat tcagttgact cc                        4182


<210>  4
<211>  1394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct 1

<400>  4

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
        275                 280                 285             


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
    290                 295                 300                 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
305                 310                 315                 320 


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
                325                 330                 335     


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
            340                 345                 350         


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
        355                 360                 365             


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
    370                 375                 380                 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
385                 390                 395                 400 


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
                405                 410                 415     


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
            420                 425                 430         


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
        435                 440                 445             


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
    450                 455                 460                 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
465                 470                 475                 480 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
                485                 490                 495     


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            500                 505                 510         


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
        515                 520                 525             


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
    530                 535                 540                 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
545                 550                 555                 560 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
                565                 570                 575     


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
            580                 585                 590         


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
        595                 600                 605             


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
    610                 615                 620                 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
625                 630                 635                 640 


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
                645                 650                 655     


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
            660                 665                 670         


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
        675                 680                 685             


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
    690                 695                 700                 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
705                 710                 715                 720 


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
                725                 730                 735     


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
            740                 745                 750         


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
        755                 760                 765             


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
    770                 775                 780                 


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
785                 790                 795                 800 


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
                805                 810                 815     


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
            820                 825                 830         


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
        835                 840                 845             


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    850                 855                 860                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
865                 870                 875                 880 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                885                 890                 895     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            900                 905                 910         


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
        915                 920                 925             


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
    930                 935                 940                 


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
945                 950                 955                 960 


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
                965                 970                 975     


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
            980                 985                 990         


Gln Ala Leu Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
        995                 1000                 1005             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1010                 1015                 1020             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1025                 1030                 1035             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1040                 1045                 1050             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1055                 1060                 1065             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1070                 1075                 1080             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1085                 1090                 1095             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1100                 1105                 1110             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1115                 1120                 1125             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1130                 1135                 1140             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1145                 1150                 1155             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1160                 1165                 1170             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1175                 1180                 1185             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1190                 1195                 1200             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1205                 1210                 1215             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1220                 1225                 1230             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1235                 1240                 1245             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1250                 1255                 1260             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1265                 1270                 1275             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1280                 1285                 1290             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1295                 1300                 1305             


Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala Val Gly  Gly Val Leu 
    1310                 1315                 1320             


Leu Phe  Leu Ser Val Asn Val  His Ala Asp Gln Gly  Cys Ala Ile 
    1325                 1330                 1335             


Asn Phe  Gly Lys Arg Glu Leu  Lys Cys Gly Asp Gly  Ile Phe Ile 
    1340                 1345                 1350             


Phe Arg  Asp Ser Asp Asp Trp  Leu Asn Lys Tyr Ser  Tyr Tyr Pro 
    1355                 1360                 1365             


Glu Asp  Pro Val Lys Leu Ala  Ser Ile Val Lys Ala  Ser Phe Glu 
    1370                 1375                 1380             


Glu Gly  Lys Cys Gly Leu Asn  Ser Val Asp Ser 
    1385                 1390                 


<210>  5
<211>  4182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 2

<400>  5
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      840

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      900

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      960

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag     1020

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag     1080

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1140

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1200

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1260

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1320

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1380

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1440

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1500

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1560

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1620

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1680

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1740

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1800

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1860

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1920

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1980

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     2040

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     2100

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tgccgccgct     2160

gcgtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2220

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2280

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2340

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2400

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2460

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2520

atactgccag acccctcaaa accgagcaag cgctccttca tagaagatct tcttttcaac     2580

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2640

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2700

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2760

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2820

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2880

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2940

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     3000

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     3060

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3120

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3180

gccgcgacaa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3240

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3300

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3360

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3420

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3480

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3540

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3600

gacctggggg atatttccgg cataaacgct tccgtggtta acatacagaa agagatagat     3660

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3720

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3780

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3840

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3900

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3960

ggagttttgc tcttcctttc ggtcaacgtc catgctgatc aaggatgcgc catcaacttt     4020

ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc tgatgactgg     4080

ctgaacaagt actcatacta tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc     4140

tcttttgaag aagggaagtg tggcctaaat tcagttgact cc                        4182


<210>  6
<211>  1394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 2

<400>  6

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
        275                 280                 285             


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
    290                 295                 300                 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
305                 310                 315                 320 


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
                325                 330                 335     


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
            340                 345                 350         


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
        355                 360                 365             


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
    370                 375                 380                 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
385                 390                 395                 400 


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
                405                 410                 415     


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
            420                 425                 430         


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
        435                 440                 445             


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
    450                 455                 460                 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
465                 470                 475                 480 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
                485                 490                 495     


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            500                 505                 510         


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
        515                 520                 525             


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
    530                 535                 540                 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
545                 550                 555                 560 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
                565                 570                 575     


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
            580                 585                 590         


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
        595                 600                 605             


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
    610                 615                 620                 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
625                 630                 635                 640 


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
                645                 650                 655     


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
            660                 665                 670         


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
        675                 680                 685             


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
    690                 695                 700                 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ala Ala 
705                 710                 715                 720 


Ala Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
                725                 730                 735     


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
            740                 745                 750         


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
        755                 760                 765             


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
    770                 775                 780                 


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
785                 790                 795                 800 


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
                805                 810                 815     


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
            820                 825                 830         


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
        835                 840                 845             


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    850                 855                 860                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
865                 870                 875                 880 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                885                 890                 895     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            900                 905                 910         


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
        915                 920                 925             


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
    930                 935                 940                 


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
945                 950                 955                 960 


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
                965                 970                 975     


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
            980                 985                 990         


Gln Ala Leu Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
        995                 1000                 1005             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1010                 1015                 1020             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1025                 1030                 1035             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1040                 1045                 1050             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1055                 1060                 1065             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1070                 1075                 1080             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1085                 1090                 1095             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1100                 1105                 1110             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1115                 1120                 1125             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1130                 1135                 1140             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1145                 1150                 1155             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1160                 1165                 1170             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1175                 1180                 1185             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1190                 1195                 1200             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1205                 1210                 1215             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1220                 1225                 1230             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1235                 1240                 1245             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1250                 1255                 1260             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1265                 1270                 1275             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1280                 1285                 1290             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1295                 1300                 1305             


Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala Val Gly  Gly Val Leu 
    1310                 1315                 1320             


Leu Phe  Leu Ser Val Asn Val  His Ala Asp Gln Gly  Cys Ala Ile 
    1325                 1330                 1335             


Asn Phe  Gly Lys Arg Glu Leu  Lys Cys Gly Asp Gly  Ile Phe Ile 
    1340                 1345                 1350             


Phe Arg  Asp Ser Asp Asp Trp  Leu Asn Lys Tyr Ser  Tyr Tyr Pro 
    1355                 1360                 1365             


Glu Asp  Pro Val Lys Leu Ala  Ser Ile Val Lys Ala  Ser Phe Glu 
    1370                 1375                 1380             


Glu Gly  Lys Cys Gly Leu Asn  Ser Val Asp Ser 
    1385                 1390                 


<210>  7
<211>  4182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 3

<400>  7
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      840

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      900

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      960

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag     1020

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag     1080

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1140

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1200

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1260

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1320

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1380

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1440

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1500

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1560

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1620

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1680

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1740

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1800

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1860

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1920

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1980

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     2040

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     2100

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tgccgccgct     2160

gcgtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2220

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2280

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2340

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2400

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2460

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2520

atactgccag acccctcaaa accgagcgcg aactccttca tagaagatct tcttttcaac     2580

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2640

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2700

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2760

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2820

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2880

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2940

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     3000

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     3060

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3120

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3180

gccgcgacaa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3240

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3300

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3360

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3420

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3480

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3540

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3600

gacctggggg atatttccgg cataaacgct tccgtggtta acatacagaa agagatagat     3660

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3720

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3780

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3840

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3900

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3960

ggagttttgc tcttcctttc ggtcaacgtc catgctgatc aaggatgcgc catcaacttt     4020

ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc tgatgactgg     4080

ctgaacaagt actcatacta tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc     4140

tcttttgaag aagggaagtg tggcctaaat tcagttgact cc                        4182


<210>  8
<211>  1394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3

<400>  8

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
        275                 280                 285             


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
    290                 295                 300                 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
305                 310                 315                 320 


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
                325                 330                 335     


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
            340                 345                 350         


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
        355                 360                 365             


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
    370                 375                 380                 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
385                 390                 395                 400 


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
                405                 410                 415     


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
            420                 425                 430         


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
        435                 440                 445             


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
    450                 455                 460                 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
465                 470                 475                 480 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
                485                 490                 495     


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            500                 505                 510         


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
        515                 520                 525             


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
    530                 535                 540                 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
545                 550                 555                 560 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
                565                 570                 575     


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
            580                 585                 590         


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
        595                 600                 605             


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
    610                 615                 620                 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
625                 630                 635                 640 


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
                645                 650                 655     


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
            660                 665                 670         


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
        675                 680                 685             


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
    690                 695                 700                 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ala Ala 
705                 710                 715                 720 


Ala Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
                725                 730                 735     


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
            740                 745                 750         


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
        755                 760                 765             


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
    770                 775                 780                 


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
785                 790                 795                 800 


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
                805                 810                 815     


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
            820                 825                 830         


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
        835                 840                 845             


Ser Ala Asn Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    850                 855                 860                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
865                 870                 875                 880 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                885                 890                 895     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            900                 905                 910         


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
        915                 920                 925             


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
    930                 935                 940                 


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
945                 950                 955                 960 


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
                965                 970                 975     


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
            980                 985                 990         


Gln Ala Leu Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
        995                 1000                 1005             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1010                 1015                 1020             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1025                 1030                 1035             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1040                 1045                 1050             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1055                 1060                 1065             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1070                 1075                 1080             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1085                 1090                 1095             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1100                 1105                 1110             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1115                 1120                 1125             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1130                 1135                 1140             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1145                 1150                 1155             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1160                 1165                 1170             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1175                 1180                 1185             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1190                 1195                 1200             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1205                 1210                 1215             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1220                 1225                 1230             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1235                 1240                 1245             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1250                 1255                 1260             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1265                 1270                 1275             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1280                 1285                 1290             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1295                 1300                 1305             


Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala Val Gly  Gly Val Leu 
    1310                 1315                 1320             


Leu Phe  Leu Ser Val Asn Val  His Ala Asp Gln Gly  Cys Ala Ile 
    1325                 1330                 1335             


Asn Phe  Gly Lys Arg Glu Leu  Lys Cys Gly Asp Gly  Ile Phe Ile 
    1340                 1345                 1350             


Phe Arg  Asp Ser Asp Asp Trp  Leu Asn Lys Tyr Ser  Tyr Tyr Pro 
    1355                 1360                 1365             


Glu Asp  Pro Val Lys Leu Ala  Ser Ile Val Lys Ala  Ser Phe Glu 
    1370                 1375                 1380             


Glu Gly  Lys Cys Gly Leu Asn  Ser Val Asp Ser 
    1385                 1390                 


<210>  9
<211>  2166
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 4

<400>  9
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggttct gttgcatctc aatcaattat tgcatacact      180

atgtcactgg gggctgagaa ttcagtagcc tactctaaca acagcatcgc gattcccact      240

aacttcacaa ttagtgtgac taccgagatc ctgccagtat ccatgactaa aactagcgta      300

gattgtacta tgtacatctg cggcgattca actgagtgtt caaacctcct cttgcaatac      360

gggtcatttt gtacccaatt gaatcgagct ctgaccggca tcgcggtcga acaggacaaa      420

aatactcaag aggtatttgc ccaggtgaag cagatttaca aaacaccccc tatcaaggat      480

ttcgggggct tcaacttcag ccagatactg ccagacccct caaaaccgag caagcgctcc      540

ttcatagaag atcttctttt caacaaagtt accctcgcgg atgctggttt cattaaacag      600

tatggggact gtctcggcga cattgctgct agagacctca tctgcgcgca aaagttcaat      660

ggacttacgg tcctgccccc tctcctcact gatgaaatga ttgctcaata tacgtccgcg      720

ttgttggcgg gaactataac cagtgggtgg acgttcggcg ctggcgccgc gcttcaaatc      780

ccatttgcga tgcaaatggc gtatcgcttc aacggcatcg gagtaactca aaacgttctg      840

tacgaaaatc aaaaactcat tgcgaaccag tttaattcag cgatcggtaa aatccaggac      900

agcctgagct ccacagcgag tgcactcggg aagctccagg atgtggtaaa tcagaacgct      960

caagcgttga acacactcgt caagcagctg tcaagtaact ttggcgcgat ttcatctgta     1020

ttgaatgaca ttctctctcg ccttgataag gtggaagccg aagtccagat tgatcgcctg     1080

attactgggc ggcttcagtc cctccaaaca tacgtcactc agcaacttat tagagccgcc     1140

gaaattaggg caagtgcgaa tctggccgcg acaaaaatgt ctgaatgtgt gctggggcag     1200

agcaagagag tcgatttttg cggtaagggg tatcacctta tgtcttttcc tcagtctgcc     1260

cctcacggag tagtgtttct ccacgttacg tatgtcccag cccaagagaa aaactttacc     1320

actgcgccgg ctatttgtca tgacggtaaa gcacactttc cacgcgaagg tgtgttcgtc     1380

tccaacggca cccactggtt tgtaacgcag aggaacttct acgagcctca gataattacc     1440

acggacaaca cgttcgtctc aggtaactgc gacgtcgtaa ttggtattgt aaataacacc     1500

gtgtacgacc cgctccagcc ggagctggac tccttcaaag aggagcttga caagtatttt     1560

aagaatcaca cttcaccgga tgtagacctg ggggatattt ccggcataaa cgcttccgtg     1620

gttaacatac agaaagagat agatcgactg aacgaggtag cgaaaaactt gaatgagtct     1680

ttgatagacc tgcaagaatt gggaaaatat gaacaatata ttaagtggcc ctggtatatt     1740

tggcttggtt tcatagccgg tttgattgcc atcgtcatgg taactataat gctttgttgc     1800

atgacaagtt gctgctcttg cctcaaaggg tgctgctcct gtggaagttg ttgcaagttc     1860

gatgaggatg attctgagcc agtgcttaag ggtgtcaaac tgcattatac gaggtcaatt     1920

gctatgacgt ttcttgcggt tggaggagtt ttgctcttcc tttcggtcaa cgtccatgct     1980

gatcaaggat gcgccatcaa ctttggcaag agagagctca agtgcggaga tggtatcttc     2040

atatttagag actctgatga ctggctgaac aagtactcat actatccaga agatcctgtg     2100

aagcttgcat caatagtgaa agcctctttt gaagaaggga agtgtggcct aaattcagtt     2160

gactcc                                                                2166


<210>  10
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4

<400>  10

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    50                  55                  60                  


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
65                  70                  75                  80  


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                85                  90                  95      


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            100                 105                 110         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        115                 120                 125             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    130                 135                 140                 


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
145                 150                 155                 160 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
                165                 170                 175     


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            180                 185                 190         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        195                 200                 205             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    210                 215                 220                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
225                 230                 235                 240 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                245                 250                 255     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            260                 265                 270         


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
        275                 280                 285             


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
    290                 295                 300                 


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
305                 310                 315                 320 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
                325                 330                 335     


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
            340                 345                 350         


Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu 
        355                 360                 365             


Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala 
    370                 375                 380                 


Ser Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln 
385                 390                 395                 400 


Ser Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe 
                405                 410                 415     


Pro Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 
            420                 425                 430         


Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp 
        435                 440                 445             


Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr 
    450                 455                 460                 


His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr 
465                 470                 475                 480 


Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile 
                485                 490                 495     


Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe 
            500                 505                 510         


Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val 
        515                 520                 525             


Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln 
    530                 535                 540                 


Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser 
545                 550                 555                 560 


Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp 
                565                 570                 575     


Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val 
            580                 585                 590         


Met Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu 
        595                 600                 605             


Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp 
    610                 615                 620                 


Ser Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr Arg Ser Ile 
625                 630                 635                 640 


Ala Met Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser Val 
                645                 650                 655     


Asn Val His Ala Asp Gln Gly Cys Ala Ile Asn Phe Gly Lys Arg Glu 
            660                 665                 670         


Leu Lys Cys Gly Asp Gly Ile Phe Ile Phe Arg Asp Ser Asp Asp Trp 
        675                 680                 685             


Leu Asn Lys Tyr Ser Tyr Tyr Pro Glu Asp Pro Val Lys Leu Ala Ser 
    690                 695                 700                 


Ile Val Lys Ala Ser Phe Glu Glu Gly Lys Cys Gly Leu Asn Ser Val 
705                 710                 715                 720 


Asp Ser 
        


<210>  11
<211>  2601
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 5

<400>  11
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      840

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      900

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      960

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag     1020

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag     1080

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1140

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1200

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1260

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1320

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1380

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1440

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1500

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1560

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1620

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1680

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1740

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1800

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1860

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1920

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1980

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     2040

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     2100

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tcgccgcgct     2160

cggtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2220

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgggaggg     2280

atgtcctgga tcacacaggg acttctggga gctcttctgt tgtggatggg aatcaatgcc     2340

cgtgacaggt caattgctat gacgtttctt gcggttggag gagttttgct cttcctttcg     2400

gtcaacgtcc atgctgatca aggatgcgcc atcaactttg gcaagagaga gctcaagtgc     2460

ggagatggta tcttcatatt tagagactct gatgactggc tgaacaagta ctcatactat     2520

ccagaagatc ctgtgaagct tgcatcaata gtgaaagcct cttttgaaga agggaagtgt     2580

ggcctaaatt cagttgactc c                                               2601


<210>  12
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 5

<400>  12

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
        275                 280                 285             


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
    290                 295                 300                 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
305                 310                 315                 320 


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
                325                 330                 335     


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
            340                 345                 350         


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
        355                 360                 365             


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
    370                 375                 380                 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
385                 390                 395                 400 


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
                405                 410                 415     


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
            420                 425                 430         


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
        435                 440                 445             


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
    450                 455                 460                 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
465                 470                 475                 480 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
                485                 490                 495     


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            500                 505                 510         


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
        515                 520                 525             


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
    530                 535                 540                 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
545                 550                 555                 560 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
                565                 570                 575     


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
            580                 585                 590         


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
        595                 600                 605             


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
    610                 615                 620                 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
625                 630                 635                 640 


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
                645                 650                 655     


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
            660                 665                 670         


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
        675                 680                 685             


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
    690                 695                 700                 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
705                 710                 715                 720 


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
                725                 730                 735     


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
            740                 745                 750         


Asn Phe Thr Ile Ser Val Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
        755                 760                 765             


Leu Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser 
    770                 775                 780                 


Ile Ala Met Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser 
785                 790                 795                 800 


Val Asn Val His Ala Asp Gln Gly Cys Ala Ile Asn Phe Gly Lys Arg 
                805                 810                 815     


Glu Leu Lys Cys Gly Asp Gly Ile Phe Ile Phe Arg Asp Ser Asp Asp 
            820                 825                 830         


Trp Leu Asn Lys Tyr Ser Tyr Tyr Pro Glu Asp Pro Val Lys Leu Ala 
        835                 840                 845             


Ser Ile Val Lys Ala Ser Phe Glu Glu Gly Lys Cys Gly Leu Asn Ser 
    850                 855                 860                 


Val Asp Ser 
865         


<210>  13
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 6

<400>  13
atgtctggtc gtaaagctca gggaaaaacc ctgggcgtca atatggtacg acgaggagtt       60

cgcggatcca tgtttgtttt cttggtcctc cttccactgg tatcctcaca atgtgtgaat      120

cttaccaccc gaacccagct tcctcccgcc tacacgaatt cattcacgcg gggtgtttat      180

tacccggata aagttttccg gtccagtgtc ctgcattcaa cccaagacct ctttctgcca      240

tttttttcta acgtgacgtg gttccatgct atccatgtaa gcggaaccaa cggaaccaaa      300

cggttcgata atccggttct cccattcaac gatggggttt acttcgcatc tacagaaaaa      360

tctaacataa ttagaggatg gatttttggg actacgcttg acagtaagac ccaatcactc      420

ttgatcgtga acaatgcaac caatgtagta attaaggttt gcgagtttca attttgtaat      480

gatccatttt tgggggttta ttaccacaaa aacaataaat cctggatgga atccgaattc      540

agagtgtata gcagcgctaa caattgcaca tttgagtacg tgtcacaacc ttttcttatg      600

gatcttgagg gcaagcaagg gaacttcaaa aatttgaggg agttcgtttt caagaacatc      660

gacggatact ttaagatcta ttctaaacac acccccatta acttggtgcg agatttgcct      720

caaggcttct ctgcacttga accgttggtg gatcttccca ttggcattaa tattactcgg      780

ttccagactt tgttggcact gcatcgctcc tatctcacgc ccggagacag ttcatctgga      840

tggactgcgg gggctgccgc gtattacgtg ggatacctgc agccgcgcac atttcttctt      900

aaatacaacg agaacgggac catcacagat gcagtggatt gcgctcttga ccccctctcc      960

gaaacaaaat gtacgctcaa gtctttcact gtagagaaag ggatttatca gacatccaat     1020

ttccgagtcc agccaacaga gagtatagtg cggttcccta acatcacaaa tctttgtccg     1080

ttcggggaag ttttcaacgc tacacgcttc gcaagtgtat acgcttggaa tagaaagagg     1140

atctctaatt gtgtggcaga ttactctgtg ctctacaatt ccgcatcttt ctcaaccttc     1200

aagtgttacg gagtttcacc tacgaagctg aacgaccttt gctttactaa tgtatatgca     1260

gatagttttg tcatcagggg cgatgaagtt cgacagatag cgcccggcca gacaggaaag     1320

atcgcggact acaattataa actccctgat gatttcaccg ggtgcgtgat cgcgtggaac     1380

tctaataacc tcgactccaa agtaggcggt aactacaatt acttgtatcg attgtttaga     1440

aaatcaaacc ttaaaccgtt cgagcgggat atctctaccg agatatacca agcaggctct     1500

acaccgtgca atggagtcga aggttttaac tgctacttcc ccttgcaatc atacgggttt     1560

cagcctacca acggtgtagg ataccagcct tacagggttg tggtactttc atttgagctc     1620

ctgcacgctc ccgcaactgt ctgtgggccc aaaaagagca ctaaccttgt taaaaataaa     1680

tgcgtcaact ttaacttcaa tggcctcact ggcaccggcg tgctcactga aagcaataag     1740

aaattccttc cttttcagca gtttgggcga gacatagcgg ataccacgga cgcagtacgg     1800

gatcctcaaa cccttgaaat ccttgacata acgccttgct cttttggggg agtaagcgta     1860

atcacgcctg gaaccaacac ctccaatcag gttgctgtgc tgtaccagga tgtaaactgc     1920

accgaggtac cggtagccat tcacgcggat cagctgactc ccacatggcg agtgtattct     1980

acaggtagta atgtgtttca gacccgagca gggtgtttga taggggcgga gcacgtcaac     2040

aactcatacg agtgcgatat acccattggg gctggtatat gtgcatccta ccagacgcag     2100

acgaactctc ctgagggacg cgggtccctg ctgacctgtg gcgacgtgga ggagaacccc     2160

ggtcctagcg gccgcaaagc ccagggtaag acactgggcg tgaacatggt tcgtcgcggc     2220

gtccgg                                                                2226


<210>  14
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 6

<400>  14

Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val 
1               5                   10                  15      


Arg Arg Gly Val Arg Gly Ser Met Phe Val Phe Leu Val Leu Leu Pro 
            20                  25                  30          


Leu Val Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro 
        35                  40                  45              


Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys 
    50                  55                  60                  


Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro 
65                  70                  75                  80  


Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr 
                85                  90                  95      


Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly 
            100                 105                 110         


Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile 
        115                 120                 125             


Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn 
    130                 135                 140                 


Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn 
145                 150                 155                 160 


Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met 
                165                 170                 175     


Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu 
            180                 185                 190         


Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn 
        195                 200                 205             


Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe 
    210                 215                 220                 


Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro 
225                 230                 235                 240 


Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile 
                245                 250                 255     


Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu 
            260                 265                 270         


Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr 
        275                 280                 285             


Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu 
    290                 295                 300                 


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser 
305                 310                 315                 320 


Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr 
                325                 330                 335     


Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe 
            340                 345                 350         


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
        355                 360                 365             


Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
    370                 375                 380                 


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
385                 390                 395                 400 


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
                405                 410                 415     


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
            420                 425                 430         


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
        435                 440                 445             


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
    450                 455                 460                 


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
465                 470                 475                 480 


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
                485                 490                 495     


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
            500                 505                 510         


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
        515                 520                 525             


Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro 
    530                 535                 540                 


Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
545                 550                 555                 560 


Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr 
                565                 570                 575     


Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile 
            580                 585                 590         


Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu 
        595                 600                 605             


Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly 
    610                 615                 620                 


Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys 
625                 630                 635                 640 


Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp 
                645                 650                 655     


Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys 
            660                 665                 670         


Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro 
        675                 680                 685             


Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
    690                 695                 700                 


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
705                 710                 715                 720 


Gly Pro Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met 
                725                 730                 735     


Val Arg Arg Gly Val Arg 
            740         


<210>  15
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct 7

<400>  15
atgtctggtc gtaaagctca gggaaaaacc ctgggcgtca atatggtacg acgaggagtt       60

cgcggatccc aatgtgtgaa tcttaccacc cgaacccagc ttcctcccgc ctacacgaat      120

tcattcacgc ggggtgttta ttacccggat aaagttttcc ggtccagtgt cctgcattca      180

acccaagacc tctttctgcc atttttttct aacgtgacgt ggttccatgc tatccatgta      240

agcggaacca acggaaccaa acggttcgat aatccggttc tcccattcaa cgatggggtt      300

tacttcgcat ctacagaaaa atctaacata attagaggat ggatttttgg gactacgctt      360

gacagtaaga cccaatcact cttgatcgtg aacaatgcaa ccaatgtagt aattaaggtt      420

tgcgagtttc aattttgtaa tgatccattt ttgggggttt attaccacaa aaacaataaa      480

tcctggatgg aatccgaatt cagagtgtat agcagcgcta acaattgcac atttgagtac      540

gtgtcacaac cttttcttat ggatcttgag ggcaagcaag ggaacttcaa aaatttgagg      600

gagttcgttt tcaagaacat cgacggatac tttaagatct attctaaaca cacccccatt      660

aacttggtgc gagatttgcc tcaaggcttc tctgcacttg aaccgttggt ggatcttccc      720

attggcatta atattactcg gttccagact ttgttggcac tgcatcgctc ctatctcacg      780

cccggagaca gttcatctgg atggactgcg ggggctgccg cgtattacgt gggatacctg      840

cagccgcgca catttcttct taaatacaac gagaacggga ccatcacaga tgcagtggat      900

tgcgctcttg accccctctc cgaaacaaaa tgtacgctca agtctttcac tgtagagaaa      960

gggatttatc agacatccaa tttccgagtc cagccaacag agagtatagt gcggttccct     1020

aacatcacaa atctttgtcc gttcggggaa gttttcaacg ctacacgctt cgcaagtgta     1080

tacgcttgga atagaaagag gatctctaat tgtgtggcag attactctgt gctctacaat     1140

tccgcatctt tctcaacctt caagtgttac ggagtttcac ctacgaagct gaacgacctt     1200

tgctttacta atgtatatgc agatagtttt gtcatcaggg gcgatgaagt tcgacagata     1260

gcgcccggcc agacaggaaa gatcgcggac tacaattata aactccctga tgatttcacc     1320

gggtgcgtga tcgcgtggaa ctctaataac ctcgactcca aagtaggcgg taactacaat     1380

tacttgtatc gattgtttag aaaatcaaac cttaaaccgt tcgagcggga tatctctacc     1440

gagatatacc aagcaggctc tacaccgtgc aatggagtcg aaggttttaa ctgctacttc     1500

cccttgcaat catacgggtt tcagcctacc aacggtgtag gataccagcc ttacagggtt     1560

gtggtacttt catttgagct cctgcacgct cccgcaactg tctgtgggcc caaaaagagc     1620

actaaccttg ttaaaaataa atgcgtcaac tttaacttca atggcctcac tggcaccggc     1680

gtgctcactg aaagcaataa gaaattcctt ccttttcagc agtttgggcg agacatagcg     1740

gataccacgg acgcagtacg ggatcctcaa acccttgaaa tccttgacat aacgccttgc     1800

tcttttgggg gagtaagcgt aatcacgcct ggaaccaaca cctccaatca ggttgctgtg     1860

ctgtaccagg atgtaaactg caccgaggta ccggtagcca ttcacgcgga tcagctgact     1920

cccacatggc gagtgtattc tacaggtagt aatgtgtttc agacccgagc agggtgtttg     1980

ataggggcgg agcacgtcaa caactcatac gagtgcgata tacccattgg ggctggtata     2040

tgtgcatcct accagacgca gacgaactct cctgagggac gcgggtccct gctgacctgt     2100

ggcgacgtgg aggagaaccc cggtcctagc ggccgcaaag cccagggtaa gacactgggc     2160

gtgaacatgg ttcgtcgcgg cgtccgg                                         2187


<210>  16
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 7

<400>  16

Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val 
1               5                   10                  15      


Arg Arg Gly Val Arg Gly Ser Gln Cys Val Asn Leu Thr Thr Arg Thr 
            20                  25                  30          


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
        35                  40                  45              


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
    50                  55                  60                  


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
65                  70                  75                  80  


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
                85                  90                  95      


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
            100                 105                 110         


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
        115                 120                 125             


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
    130                 135                 140                 


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
145                 150                 155                 160 


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
                165                 170                 175     


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
            180                 185                 190         


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
        195                 200                 205             


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
    210                 215                 220                 


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
225                 230                 235                 240 


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
                245                 250                 255     


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
            260                 265                 270         


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
        275                 280                 285             


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
    290                 295                 300                 


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
305                 310                 315                 320 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
                325                 330                 335     


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            340                 345                 350         


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        355                 360                 365             


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    370                 375                 380                 


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
385                 390                 395                 400 


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                405                 410                 415     


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            420                 425                 430         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        435                 440                 445             


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    450                 455                 460                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
465                 470                 475                 480 


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
                485                 490                 495     


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            500                 505                 510         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        515                 520                 525             


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
    530                 535                 540                 


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
545                 550                 555                 560 


Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
                565                 570                 575     


Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu 
            580                 585                 590         


Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
        595                 600                 605             


Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp 
    610                 615                 620                 


Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr 
625                 630                 635                 640 


Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg 
                645                 650                 655     


Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys 
            660                 665                 670         


Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr 
        675                 680                 685             


Asn Ser Pro Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
    690                 695                 700                 


Glu Asn Pro Gly Pro Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly 
705                 710                 715                 720 


Val Asn Met Val Arg Arg Gly Val Arg 
                725                 


<210>  17
<211>  1764
<212>  DNA
<213>  SARS-CoV-2

<400>  17
tctgttgcat ctcaatcaat tattgcatac actatgtcac tgggggctga gaattcagta       60

gcctactcta acaacagcat cgcgattccc actaacttca caattagtgt gactaccgag      120

atcctgccag tatccatgac taaaactagc gtagattgta ctatgtacat ctgcggcgat      180

tcaactgagt gttcaaacct cctcttgcaa tacgggtcat tttgtaccca attgaatcga      240

gctctgaccg gcatcgcggt cgaacaggac aaaaatactc aagaggtatt tgcccaggtg      300

aagcagattt acaaaacacc ccctatcaag gatttcgggg gcttcaactt cagccagata      360

ctgccagacc cctcaaaacc gagcaagcgc tccttcatag aagatcttct tttcaacaaa      420

gttaccctcg cggatgctgg tttcattaaa cagtatgggg actgtctcgg cgacattgct      480

gctagagacc tcatctgcgc gcaaaagttc aatggactta cggtcctgcc ccctctcctc      540

actgatgaaa tgattgctca atatacgtcc gcgttgttgg cgggaactat aaccagtggg      600

tggacgttcg gcgctggcgc cgcgcttcaa atcccatttg cgatgcaaat ggcgtatcgc      660

ttcaacggca tcggagtaac tcaaaacgtt ctgtacgaaa atcaaaaact cattgcgaac      720

cagtttaatt cagcgatcgg taaaatccag gacagcctga gctccacagc gagtgcactc      780

gggaagctcc aggatgtggt aaatcagaac gctcaagcgt tgaacacact cgtcaagcag      840

ctgtcaagta actttggcgc gatttcatct gtattgaatg acattctctc tcgccttgat      900

aaggtggaag ccgaagtcca gattgatcgc ctgattactg ggcggcttca gtccctccaa      960

acatacgtca ctcagcaact tattagagcc gccgaaatta gggcaagtgc gaatctggcc     1020

gcgacaaaaa tgtctgaatg tgtgctgggg cagagcaaga gagtcgattt ttgcggtaag     1080

gggtatcacc ttatgtcttt tcctcagtct gcccctcacg gagtagtgtt tctccacgtt     1140

acgtatgtcc cagcccaaga gaaaaacttt accactgcgc cggctatttg tcatgacggt     1200

aaagcacact ttccacgcga aggtgtgttc gtctccaacg gcacccactg gtttgtaacg     1260

cagaggaact tctacgagcc tcagataatt accacggaca acacgttcgt ctcaggtaac     1320

tgcgacgtcg taattggtat tgtaaataac accgtgtacg acccgctcca gccggagctg     1380

gactccttca aagaggagct tgacaagtat tttaagaatc acacttcacc ggatgtagac     1440

ctgggggata tttccggcat aaacgcttcc gtggttaaca tacagaaaga gatagatcga     1500

ctgaacgagg tagcgaaaaa cttgaatgag tctttgatag acctgcaaga attgggaaaa     1560

tatgaacaat atattaagtg gccctggtat atttggcttg gtttcatagc cggtttgatt     1620

gccatcgtca tggtaactat aatgctttgt tgcatgacaa gttgctgctc ttgcctcaaa     1680

gggtgctgct cctgtggaag ttgttgcaag ttcgatgagg atgattctga gccagtgctt     1740

aagggtgtca aactgcatta tacg                                            1764


<210>  18
<211>  2010
<212>  DNA
<213>  SARS-CoV-2

<400>  18
gtgaatctta ccacccgaac ccagcttcct cccgcctaca cgaattcatt cacgcggggt       60

gtttattacc cggataaagt tttccggtcc agtgtcctgc attcaaccca agacctcttt      120

ctgccatttt tttctaacgt gacgtggttc catgctatcc atgtaagcgg aaccaacgga      180

accaaacggt tcgataatcc ggttctccca ttcaacgatg gggtttactt cgcatctaca      240

gaaaaatcta acataattag aggatggatt tttgggacta cgcttgacag taagacccaa      300

tcactcttga tcgtgaacaa tgcaaccaat gtagtaatta aggtttgcga gtttcaattt      360

tgtaatgatc catttttggg ggtttattac cacaaaaaca ataaatcctg gatggaatcc      420

gaattcagag tgtatagcag cgctaacaat tgcacatttg agtacgtgtc acaacctttt      480

cttatggatc ttgagggcaa gcaagggaac ttcaaaaatt tgagggagtt cgttttcaag      540

aacatcgacg gatactttaa gatctattct aaacacaccc ccattaactt ggtgcgagat      600

ttgcctcaag gcttctctgc acttgaaccg ttggtggatc ttcccattgg cattaatatt      660

actcggttcc agactttgtt ggcactgcat cgctcctatc tcacgcccgg agacagttca      720

tctggatgga ctgcgggggc tgccgcgtat tacgtgggat acctgcagcc gcgcacattt      780

cttcttaaat acaacgagaa cgggaccatc acagatgcag tggattgcgc tcttgacccc      840

ctctccgaaa caaaatgtac gctcaagtct ttcactgtag agaaagggat ttatcagaca      900

tccaatttcc gagtccagcc aacagagagt atagtgcggt tccctaacat cacaaatctt      960

tgtccgttcg gggaagtttt caacgctaca cgcttcgcaa gtgtatacgc ttggaataga     1020

aagaggatct ctaattgtgt ggcagattac tctgtgctct acaattccgc atctttctca     1080

accttcaagt gttacggagt ttcacctacg aagctgaacg acctttgctt tactaatgta     1140

tatgcagata gttttgtcat caggggcgat gaagttcgac agatagcgcc cggccagaca     1200

ggaaagatcg cggactacaa ttataaactc cctgatgatt tcaccgggtg cgtgatcgcg     1260

tggaactcta ataacctcga ctccaaagta ggcggtaact acaattactt gtatcgattg     1320

tttagaaaat caaaccttaa accgttcgag cgggatatct ctaccgagat ataccaagca     1380

ggctctacac cgtgcaatgg agtcgaaggt tttaactgct acttcccctt gcaatcatac     1440

gggtttcagc ctaccaacgg tgtaggatac cagccttaca gggttgtggt actttcattt     1500

gagctcctgc acgctcccgc aactgtctgt gggcccaaaa agagcactaa ccttgttaaa     1560

aataaatgcg tcaactttaa cttcaatggc ctcactggca ccggcgtgct cactgaaagc     1620

aataagaaat tccttccttt tcagcagttt gggcgagaca tagcggatac cacggacgca     1680

gtacgggatc ctcaaaccct tgaaatcctt gacataacgc cttgctcttt tgggggagta     1740

agcgtaatca cgcctggaac caacacctcc aatcaggttg ctgtgctgta ccaggatgta     1800

aactgcaccg aggtaccggt agccattcac gcggatcagc tgactcccac atggcgagtg     1860

tattctacag gtagtaatgt gtttcagacc cgagcagggt gtttgatagg ggcggagcac     1920

gtcaacaact catacgagtg cgatataccc attggggctg gtatatgtgc atcctaccag     1980

acgcagacga actctcctcg ccgcgctcgg                                      2010


<210>  19
<211>  3774
<212>  DNA
<213>  SARS-CoV-2

<400>  19
gtgaatctta ccacccgaac ccagcttcct cccgcctaca cgaattcatt cacgcggggt       60

gtttattacc cggataaagt tttccggtcc agtgtcctgc attcaaccca agacctcttt      120

ctgccatttt tttctaacgt gacgtggttc catgctatcc atgtaagcgg aaccaacgga      180

accaaacggt tcgataatcc ggttctccca ttcaacgatg gggtttactt cgcatctaca      240

gaaaaatcta acataattag aggatggatt tttgggacta cgcttgacag taagacccaa      300

tcactcttga tcgtgaacaa tgcaaccaat gtagtaatta aggtttgcga gtttcaattt      360

tgtaatgatc catttttggg ggtttattac cacaaaaaca ataaatcctg gatggaatcc      420

gaattcagag tgtatagcag cgctaacaat tgcacatttg agtacgtgtc acaacctttt      480

cttatggatc ttgagggcaa gcaagggaac ttcaaaaatt tgagggagtt cgttttcaag      540

aacatcgacg gatactttaa gatctattct aaacacaccc ccattaactt ggtgcgagat      600

ttgcctcaag gcttctctgc acttgaaccg ttggtggatc ttcccattgg cattaatatt      660

actcggttcc agactttgtt ggcactgcat cgctcctatc tcacgcccgg agacagttca      720

tctggatgga ctgcgggggc tgccgcgtat tacgtgggat acctgcagcc gcgcacattt      780

cttcttaaat acaacgagaa cgggaccatc acagatgcag tggattgcgc tcttgacccc      840

ctctccgaaa caaaatgtac gctcaagtct ttcactgtag agaaagggat ttatcagaca      900

tccaatttcc gagtccagcc aacagagagt atagtgcggt tccctaacat cacaaatctt      960

tgtccgttcg gggaagtttt caacgctaca cgcttcgcaa gtgtatacgc ttggaataga     1020

aagaggatct ctaattgtgt ggcagattac tctgtgctct acaattccgc atctttctca     1080

accttcaagt gttacggagt ttcacctacg aagctgaacg acctttgctt tactaatgta     1140

tatgcagata gttttgtcat caggggcgat gaagttcgac agatagcgcc cggccagaca     1200

ggaaagatcg cggactacaa ttataaactc cctgatgatt tcaccgggtg cgtgatcgcg     1260

tggaactcta ataacctcga ctccaaagta ggcggtaact acaattactt gtatcgattg     1320

tttagaaaat caaaccttaa accgttcgag cgggatatct ctaccgagat ataccaagca     1380

ggctctacac cgtgcaatgg agtcgaaggt tttaactgct acttcccctt gcaatcatac     1440

gggtttcagc ctaccaacgg tgtaggatac cagccttaca gggttgtggt actttcattt     1500

gagctcctgc acgctcccgc aactgtctgt gggcccaaaa agagcactaa ccttgttaaa     1560

aataaatgcg tcaactttaa cttcaatggc ctcactggca ccggcgtgct cactgaaagc     1620

aataagaaat tccttccttt tcagcagttt gggcgagaca tagcggatac cacggacgca     1680

gtacgggatc ctcaaaccct tgaaatcctt gacataacgc cttgctcttt tgggggagta     1740

agcgtaatca cgcctggaac caacacctcc aatcaggttg ctgtgctgta ccaggatgta     1800

aactgcaccg aggtaccggt agccattcac gcggatcagc tgactcccac atggcgagtg     1860

tattctacag gtagtaatgt gtttcagacc cgagcagggt gtttgatagg ggcggagcac     1920

gtcaacaact catacgagtg cgatataccc attggggctg gtatatgtgc atcctaccag     1980

acgcagacga actctcctcg ccgcgctcgg tctgttgcat ctcaatcaat tattgcatac     2040

actatgtcac tgggggctga gaattcagta gcctactcta acaacagcat cgcgattccc     2100

actaacttca caattagtgt gactaccgag atcctgccag tatccatgac taaaactagc     2160

gtagattgta ctatgtacat ctgcggcgat tcaactgagt gttcaaacct cctcttgcaa     2220

tacgggtcat tttgtaccca attgaatcga gctctgaccg gcatcgcggt cgaacaggac     2280

aaaaatactc aagaggtatt tgcccaggtg aagcagattt acaaaacacc ccctatcaag     2340

gatttcgggg gcttcaactt cagccagata ctgccagacc cctcaaaacc gagcaagcgc     2400

tccttcatag aagatcttct tttcaacaaa gttaccctcg cggatgctgg tttcattaaa     2460

cagtatgggg actgtctcgg cgacattgct gctagagacc tcatctgcgc gcaaaagttc     2520

aatggactta cggtcctgcc ccctctcctc actgatgaaa tgattgctca atatacgtcc     2580

gcgttgttgg cgggaactat aaccagtggg tggacgttcg gcgctggcgc cgcgcttcaa     2640

atcccatttg cgatgcaaat ggcgtatcgc ttcaacggca tcggagtaac tcaaaacgtt     2700

ctgtacgaaa atcaaaaact cattgcgaac cagtttaatt cagcgatcgg taaaatccag     2760

gacagcctga gctccacagc gagtgcactc gggaagctcc aggatgtggt aaatcagaac     2820

gctcaagcgt tgaacacact cgtcaagcag ctgtcaagta actttggcgc gatttcatct     2880

gtattgaatg acattctctc tcgccttgat aaggtggaag ccgaagtcca gattgatcgc     2940

ctgattactg ggcggcttca gtccctccaa acatacgtca ctcagcaact tattagagcc     3000

gccgaaatta gggcaagtgc gaatctggcc gcgacaaaaa tgtctgaatg tgtgctgggg     3060

cagagcaaga gagtcgattt ttgcggtaag gggtatcacc ttatgtcttt tcctcagtct     3120

gcccctcacg gagtagtgtt tctccacgtt acgtatgtcc cagcccaaga gaaaaacttt     3180

accactgcgc cggctatttg tcatgacggt aaagcacact ttccacgcga aggtgtgttc     3240

gtctccaacg gcacccactg gtttgtaacg cagaggaact tctacgagcc tcagataatt     3300

accacggaca acacgttcgt ctcaggtaac tgcgacgtcg taattggtat tgtaaataac     3360

accgtgtacg acccgctcca gccggagctg gactccttca aagaggagct tgacaagtat     3420

tttaagaatc acacttcacc ggatgtagac ctgggggata tttccggcat aaacgcttcc     3480

gtggttaaca tacagaaaga gatagatcga ctgaacgagg tagcgaaaaa cttgaatgag     3540

tctttgatag acctgcaaga attgggaaaa tatgaacaat atattaagtg gccctggtat     3600

atttggcttg gtttcatagc cggtttgatt gccatcgtca tggtaactat aatgctttgt     3660

tgcatgacaa gttgctgctc ttgcctcaaa gggtgctgct cctgtggaag ttgttgcaag     3720

ttcgatgagg atgattctga gccagtgctt aagggtgtca aactgcatta tacg           3774


<210>  20
<211>  39
<212>  DNA
<213>  SARS-CoV2

<400>  20
atgtttgttt tcttggtcct ccttccactg gtatcctca                              39


<210>  21
<211>  12
<212>  DNA
<213>  SARS-CoV2

<400>  21
cgccgcgctc gg                                                           12


<210>  22
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated S1/S2 cleavage site

<400>  22
gccgccgctg cg                                                           12


<210>  23
<211>  4
<212>  PRT
<213>  SARS-CoV2

<400>  23

Arg Arg Ala Arg 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated S1/S2 cleavage site

<400>  24

Ala Ala Ala Ala 
1               


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal part of the capsid protein of the flavivirus

<400>  25

Met Ser Gly Arg Lys Ala Gln Gly Lys Thr Leu Gly Val Asn Met Val 
1               5                   10                  15      


Arg Arg Gly Val Arg 
            20      


<210>  26
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-terminal part of the capsid protein of the flavivirus

<400>  26
atgtctggtc gtaaagctca gggaaaaacc ctgggcgtca atatggtacg acgaggagtt       60

cgc                                                                     63


<210>  27
<211>  18
<212>  PRT
<213>  Thosea asigna virus

<400>  27

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  28
<211>  24
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  28

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  29
<211>  19
<212>  PRT
<213>  porcine teschovirus-1

<400>  29

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  30
<211>  20
<212>  PRT
<213>  equine rhinitis A virus

<400>  30

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  SITE
<222>  (2)..(4)
<223>  X can be any amino acid

<220>
<221>  SITE
<222>  (9)..(9)
<223>  X can be any amino acid

<400>  31

Leu Xaa Xaa Xaa Gly Asp Val Glu Xaa Asn Pro Gly Pro 
1               5                   10              


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence


<220>
<221>  SITE
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  SITE
<222>  (4)..(4)
<223>  X can be any amino acid

<400>  32

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A 'cleavage' site

<400>  33

Asn Pro Gly Pro 
1               


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A 'cleavage' site

<400>  34

Asn Pro Gly Pro Ser 
1               5   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of the NS1 protein of the flavivirus

<400>  35

Asp Gln Gly Cys Ala Ile Asn Phe Gly 
1               5                   


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fragment of the NS1 protein of the flavivirus

<400>  36
gaccagggct gcgcgataaa tttcggt                                           27


<210>  37
<211>  69
<212>  DNA
<213>  West Nile virus

<400>  37
aggtcaattg ctatgacgtt tcttgcggtt ggaggagttt tgctcttcct ttcggtcaac       60

gtccatgct                                                               69


<210>  38
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NS1 signal peptide

<400>  38
gaccagggct gcgcgataaa tttcggt                                           27


<210>  39
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  combination signal peptides

<400>  39
gaccagggct gcgcgataaa tttcggtcaa tgt                                    33


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 primer 1

<400>  40
ttacaaacat tggccgcaaa                                                   20


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 primer 2

<400>  41
gcgcgacatt ccgaagaa                                                     18


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  coupled to BHQ1

<400>  42
acaatttgcc cccagcgctt cag                                               23


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACE2 primer 1

<400>  43
gggaactgtc aaagggtaca g                                                 21


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACE2 primer 2

<400>  44
cccttcctac atcagtccta ct                                                22


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACE2 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to FAM

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  coupled to ZEN/IABkFQ

<400>  45
tccctgctca tttgcttggt gaca                                              24


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACTB primer 1

<400>  46
ggccaggtca tcaccatt                                                     18


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACTB primer 2

<400>  47
gagttgaatg tagtttcgtg gatg                                              24


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster ACTB probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to Cy5

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  coupled to IBRQ

<400>  48
tttccagcct tccttcctgg gtatg                                             25


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN gamma primer 1

<400>  49
tttctccatg ctgctgttga a                                                 21


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN gamma  primer 2

<400>  50
ggccatccag aggagcatag                                                   20


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN gamma probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  coupled to ZEN/IABkFQ

<400>  51
caccatcaag gcagacctgt ttgctaactt                                        30


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN lambda primer 1

<400>  52
cccaccagat gcaaaggatt                                                   20


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN lambda primer 2

<400>  53
cttgagcagc cactcttcta tg                                                22


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IFN lambda probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  coupled to ZEN/IABkFQ

<400>  54
acatagcccg gttcaagtct ctgc                                              24


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-2 primer 1

<400>  55
aagctcctgt aagtccagca gtaac                                             25


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-2  primer 2

<400>  56
gtgcacccac ttcaagctct aa                                                22


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-2 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  coupled to ZEN/IABkFQ"

<400>  57
aggaaaccca gcagcacctc gagc                                              24


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-4 primer 1

<400>  58
gggtcacctc atgttggaaa taaa                                              24


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-4 primer 2

<400>  59
ccacggagaa agacctcatc tg                                                22


<210>  60
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-4 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  coupled to ZEN/IABkFQ

<400>  60
cagggcttcc caggtgcttc gcaagt                                            26


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-6 primer 1

<400>  61
ggtatgctaa ggcacagcac act                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-6 primer 2

<400>  62
cctgaaagca cttgaagaat tcc                                               23


<210>  63
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-6 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  coupled to ZEN/IABkFQ

<400>  63
agaagtcacc atgaggtcta ctcggcaaaa                                        30


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-10 primer 1

<400>  64
ttctggcccg tggttctct                                                    19


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-10 primer 2

<400>  65
gttgccaaac cttatcagaa atga                                              24


<210>  66
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IL-10 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  coupled to ZEN/IABkFQ

<400>  66
cagttttacc tggtagaagt gatgccccag g                                      31


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IP-10 primer 1

<400>  67
gccattcatc cacagttgac a                                                 21


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IP-10 primer 2

<400>  68
catggtgctg acagtggagt ct                                                22


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster IP-10 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  coupled to ZEN/IABkFQ

<400>  69
cgtcccgagc cagccaacga                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster MX2 primer 1

<400>  70
ccagtaatgt ggacattgcc                                                   20


<210>  71
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster MX2  primer 2

<400>  71
catcaacgac cttgtcttca gta                                               23


<210>  72
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster MX2  probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  coupled to ZEN/IABkFQ

<400>  72
tgtccaccag atcaggcttg gtca                                              24


<210>  73
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster TNF primer 1

<400>  73
agctggttgt ctttgagaga catg                                              24


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster TNF primer 2

<400>  74
ggagtggctg agccatcgt                                                    19


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hamster  TNF  probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to fluorescein (FAM)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  coupled to ZEN/IABkFQ

<400>  75
ccaatgccct cctggccaac g                                                 21


<210>  76
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GADPH primer 1

<400>  76
gtggagtcat acggaacatg tag                                               23


<210>  77
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GADPH primer 2

<400>  77
aatggtgaag gtcggtgtg                                                    19


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GADPH probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to 56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  coupled to internal ZEN quencher

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  coupled to ZEN/IABkFQ

<400>  78
tgcaaatggc agccctggtg                                                   20


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Tbx21 primer 1

<400>  79
caagaccaca tccacaaaca tc                                                22


<210>  80
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Tbx21 primer 2

<400>  80
ttcaaccagc accagacag                                                    19


<210>  81
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Tbx21 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to 56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  coupled to internal ZEN quencher

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  coupled to 3IABkFQ

<400>  81
tcactaagca aggacggcga atgt                                              24


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GATA3 primer 1

<400>  82
gtccccatta gcgttcctc                                                    19


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GATA3 primer 2

<400>  83
ccttatcaag cccaagcgaa                                                   20


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GATA3 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to 56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  coupled to internal ZEN quencher

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  coupled to 3IABkFQ

<400>  84
tgtccctgct ctccttgctg c                                                 21


<210>  85
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse RORO primer 1

<400>  85
gaggtgctgg aagatctgc                                                    19


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse RORO primer 2

<400>  86
tctgcaagac tcatcgacaa g                                                 21


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse RORO probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to 56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  coupled to internal ZEN quencher

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  coupled to 3IABkFQ

<400>  87
ctagccaagc tgccacccaa ag                                                22


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse FOXP3 primer 1

<400>  88
ctgtcttcca agtctcgtct g                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse FOXP3 primer 2

<400>  89
ctggtctctg caggtttagt g                                                 21


<210>  90
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse FOXP3 probe


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  coupled to 56-FAM

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  coupled to internal ZEN quencher

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  coupled 3IABkFQ

<400>  90
ctgtgcctgg tatatgctcc cgg                                               23


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated S1/S2 cleavage site

<400>  91

Ser Gly Ala Gly 
1               


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated S1/S2 cleavage site

<400>  92

Gly Ser Ala Ser 
1               


<210>  93
<211>  3876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fragment of construct 1

<400>  93
gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt       60

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      120

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      180

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      240

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      300

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      360

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      420

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      480

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      540

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      600

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      660

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      720

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      780

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      840

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag      900

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag      960

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1020

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1080

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1140

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1200

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1260

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1320

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1380

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1440

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1500

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1560

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1620

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1680

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1740

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1800

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1860

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     1920

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     1980

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tcgccgcgct     2040

cggtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2100

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2160

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2220

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2280

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2340

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2400

atactgccag acccctcaaa accgagcaag cgctccttca tagaagatct tcttttcaac     2460

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2520

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2580

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2640

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2700

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2760

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2820

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     2880

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     2940

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3000

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3060

gccgcgacaa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3120

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3180

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3240

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3300

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3360

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3420

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3480

gacctggggg atatttccgg cataaacgct tccgtggtta acatacagaa agagatagat     3540

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3600

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3660

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3720

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3780

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3840

ggagttttgc tcttcctttc ggtcaacgtc catgct                               3876


<210>  94
<211>  3876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fragment of construct 2

<400>  94
gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt       60

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      120

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      180

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      240

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      300

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      360

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      420

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      480

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      540

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      600

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      660

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      720

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      780

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      840

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag      900

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag      960

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1020

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1080

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1140

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1200

gatgaagttc gacagatagc gcccggccag acaggaaaga tcgcggacta caattataaa     1260

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1320

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1380

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcgaa     1440

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccaa cggtgtagga     1500

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1560

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1620

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1680

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1740

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1800

tccaatcagg ttgctgtgct gtaccaggat gtaaactgca ccgaggtacc ggtagccatt     1860

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     1920

acccgagcag ggtgtttgat aggggcggag cacgtcaaca actcatacga gtgcgatata     1980

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tgccgccgct     2040

gcgtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2100

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2160

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2220

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2280

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2340

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2400

atactgccag acccctcaaa accgagcaag cgctccttca tagaagatct tcttttcaac     2460

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2520

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2580

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2640

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2700

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2760

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2820

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     2880

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     2940

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3000

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3060

gccgcgacaa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3120

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3180

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3240

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3300

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3360

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3420

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3480

gacctggggg atatttccgg cataaacgct tccgtggtta acatacagaa agagatagat     3540

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3600

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3660

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3720

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3780

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3840

ggagttttgc tcttcctttc ggtcaacgtc catgct                               3876


<210>  95
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of construct 1

<400>  95

Asp Gln Gly Cys Ala Ile Asn Phe Gly Gln Cys Val Asn Leu Thr Thr 
1               5                   10                  15      


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
            20                  25                  30          


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
        35                  40                  45              


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
    50                  55                  60                  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
65                  70                  75                  80  


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
                85                  90                  95      


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
            100                 105                 110         


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
        115                 120                 125             


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
    130                 135                 140                 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
145                 150                 155                 160 


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
                165                 170                 175     


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
            180                 185                 190         


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
        195                 200                 205             


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
    210                 215                 220                 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
225                 230                 235                 240 


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
                245                 250                 255     


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
            260                 265                 270         


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
        275                 280                 285             


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
    290                 295                 300                 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
305                 310                 315                 320 


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
                325                 330                 335     


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
            340                 345                 350         


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
        355                 360                 365             


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
    370                 375                 380                 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
385                 390                 395                 400 


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
                405                 410                 415     


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
            420                 425                 430         


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
        435                 440                 445             


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
    450                 455                 460                 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
465                 470                 475                 480 


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
                485                 490                 495     


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
            500                 505                 510         


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
        515                 520                 525             


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
    530                 535                 540                 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
545                 550                 555                 560 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
                565                 570                 575     


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
            580                 585                 590         


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
        595                 600                 605             


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
    610                 615                 620                 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
625                 630                 635                 640 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
                645                 650                 655     


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
            660                 665                 670         


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala 
    1265                 1270                 1275             


Val Gly  Gly Val Leu Leu Phe  Leu Ser Val Asn Val  His Ala Asp 
    1280                 1285                 1290             


Gln Gly  Cys Ala Ile Asn Phe  Gly Lys Arg Glu Leu  Lys Cys Gly 
    1295                 1300                 1305             


Asp Gly  Ile Phe Ile Phe Arg  Asp Ser Asp Asp Trp  Leu Asn Lys 
    1310                 1315                 1320             


Tyr Ser  Tyr Tyr Pro Glu Asp  Pro Val Lys Leu Ala  Ser Ile Val 
    1325                 1330                 1335             


Lys Ala  Ser Phe Glu Glu Gly  Lys Cys Gly Leu Asn  Ser Val Asp 
    1340                 1345                 1350             


Ser 
    


<210>  96
<211>  1292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fragment of construct 2

<400>  96

Asp Gln Gly Cys Ala Ile Asn Phe Gly Gln Cys Val Asn Leu Thr Thr 
1               5                   10                  15      


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
            20                  25                  30          


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
        35                  40                  45              


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
    50                  55                  60                  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
65                  70                  75                  80  


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
                85                  90                  95      


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
            100                 105                 110         


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
        115                 120                 125             


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
    130                 135                 140                 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
145                 150                 155                 160 


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
                165                 170                 175     


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
            180                 185                 190         


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
        195                 200                 205             


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
    210                 215                 220                 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
225                 230                 235                 240 


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
                245                 250                 255     


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
            260                 265                 270         


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
        275                 280                 285             


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
    290                 295                 300                 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
305                 310                 315                 320 


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
                325                 330                 335     


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
            340                 345                 350         


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
        355                 360                 365             


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
    370                 375                 380                 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
385                 390                 395                 400 


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
                405                 410                 415     


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
            420                 425                 430         


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
        435                 440                 445             


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
    450                 455                 460                 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
465                 470                 475                 480 


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
                485                 490                 495     


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
            500                 505                 510         


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
        515                 520                 525             


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
    530                 535                 540                 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
545                 550                 555                 560 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
                565                 570                 575     


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
            580                 585                 590         


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
        595                 600                 605             


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
    610                 615                 620                 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
625                 630                 635                 640 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
                645                 650                 655     


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
            660                 665                 670         


Gln Thr Asn Ser Pro Ala Ala Ala Ala Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala 
    1265                 1270                 1275             


Val Gly  Gly Val Leu Leu Phe  Leu Ser Val Asn Val  His Ala 
    1280                 1285                 1290         


<210>  97
<211>  3774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fragment of construct 1

<400>  97
gtgaatctta ccacccgaac ccagcttcct cccgcctaca cgaattcatt cacgcggggt       60

gtttattacc cggataaagt tttccggtcc agtgtcctgc attcaaccca agacctcttt      120

ctgccatttt tttctaacgt gacgtggttc catgctatcc atgtaagcgg aaccaacgga      180

accaaacggt tcgataatcc ggttctccca ttcaacgatg gggtttactt cgcatctaca      240

gaaaaatcta acataattag aggatggatt tttgggacta cgcttgacag taagacccaa      300

tcactcttga tcgtgaacaa tgcaaccaat gtagtaatta aggtttgcga gtttcaattt      360

tgtaatgatc catttttggg ggtttattac cacaaaaaca ataaatcctg gatggaatcc      420

gaattcagag tgtatagcag cgctaacaat tgcacatttg agtacgtgtc acaacctttt      480

cttatggatc ttgagggcaa gcaagggaac ttcaaaaatt tgagggagtt cgttttcaag      540

aacatcgacg gatactttaa gatctattct aaacacaccc ccattaactt ggtgcgagat      600

ttgcctcaag gcttctctgc acttgaaccg ttggtggatc ttcccattgg cattaatatt      660

actcggttcc agactttgtt ggcactgcat cgctcctatc tcacgcccgg agacagttca      720

tctggatgga ctgcgggggc tgccgcgtat tacgtgggat acctgcagcc gcgcacattt      780

cttcttaaat acaacgagaa cgggaccatc acagatgcag tggattgcgc tcttgacccc      840

ctctccgaaa caaaatgtac gctcaagtct ttcactgtag agaaagggat ttatcagaca      900

tccaatttcc gagtccagcc aacagagagt atagtgcggt tccctaacat cacaaatctt      960

tgtccgttcg gggaagtttt caacgctaca cgcttcgcaa gtgtatacgc ttggaataga     1020

aagaggatct ctaattgtgt ggcagattac tctgtgctct acaattccgc atctttctca     1080

accttcaagt gttacggagt ttcacctacg aagctgaacg acctttgctt tactaatgta     1140

tatgcagata gttttgtcat caggggcgat gaagttcgac agatagcgcc cggccagaca     1200

ggaaagatcg cggactacaa ttataaactc cctgatgatt tcaccgggtg cgtgatcgcg     1260

tggaactcta ataacctcga ctccaaagta ggcggtaact acaattactt gtatcgattg     1320

tttagaaaat caaaccttaa accgttcgag cgggatatct ctaccgagat ataccaagca     1380

ggctctacac cgtgcaatgg agtcgaaggt tttaactgct acttcccctt gcaatcatac     1440

gggtttcagc ctaccaacgg tgtaggatac cagccttaca gggttgtggt actttcattt     1500

gagctcctgc acgctcccgc aactgtctgt gggcccaaaa agagcactaa ccttgttaaa     1560

aataaatgcg tcaactttaa cttcaatggc ctcactggca ccggcgtgct cactgaaagc     1620

aataagaaat tccttccttt tcagcagttt gggcgagaca tagcggatac cacggacgca     1680

gtacgggatc ctcaaaccct tgaaatcctt gacataacgc cttgctcttt tgggggagta     1740

agcgtaatca cgcctggaac caacacctcc aatcaggttg ctgtgctgta ccaggatgta     1800

aactgcaccg aggtaccggt agccattcac gcggatcagc tgactcccac atggcgagtg     1860

tattctacag gtagtaatgt gtttcagacc cgagcagggt gtttgatagg ggcggagcac     1920

gtcaacaact catacgagtg cgatataccc attggggctg gtatatgtgc atcctaccag     1980

acgcagacga actctcctgc cgccgctgcg tctgttgcat ctcaatcaat tattgcatac     2040

actatgtcac tgggggctga gaattcagta gcctactcta acaacagcat cgcgattccc     2100

actaacttca caattagtgt gactaccgag atcctgccag tatccatgac taaaactagc     2160

gtagattgta ctatgtacat ctgcggcgat tcaactgagt gttcaaacct cctcttgcaa     2220

tacgggtcat tttgtaccca attgaatcga gctctgaccg gcatcgcggt cgaacaggac     2280

aaaaatactc aagaggtatt tgcccaggtg aagcagattt acaaaacacc ccctatcaag     2340

gatttcgggg gcttcaactt cagccagata ctgccagacc cctcaaaacc gagcaagcgc     2400

tccttcatag aagatcttct tttcaacaaa gttaccctcg cggatgctgg tttcattaaa     2460

cagtatgggg actgtctcgg cgacattgct gctagagacc tcatctgcgc gcaaaagttc     2520

aatggactta cggtcctgcc ccctctcctc actgatgaaa tgattgctca atatacgtcc     2580

gcgttgttgg cgggaactat aaccagtggg tggacgttcg gcgctggcgc cgcgcttcaa     2640

atcccatttg cgatgcaaat ggcgtatcgc ttcaacggca tcggagtaac tcaaaacgtt     2700

ctgtacgaaa atcaaaaact cattgcgaac cagtttaatt cagcgatcgg taaaatccag     2760

gacagcctga gctccacagc gagtgcactc gggaagctcc aggatgtggt aaatcagaac     2820

gctcaagcgt tgaacacact cgtcaagcag ctgtcaagta actttggcgc gatttcatct     2880

gtattgaatg acattctctc tcgccttgat aaggtggaag ccgaagtcca gattgatcgc     2940

ctgattactg ggcggcttca gtccctccaa acatacgtca ctcagcaact tattagagcc     3000

gccgaaatta gggcaagtgc gaatctggcc gcgacaaaaa tgtctgaatg tgtgctgggg     3060

cagagcaaga gagtcgattt ttgcggtaag gggtatcacc ttatgtcttt tcctcagtct     3120

gcccctcacg gagtagtgtt tctccacgtt acgtatgtcc cagcccaaga gaaaaacttt     3180

accactgcgc cggctatttg tcatgacggt aaagcacact ttccacgcga aggtgtgttc     3240

gtctccaacg gcacccactg gtttgtaacg cagaggaact tctacgagcc tcagataatt     3300

accacggaca acacgttcgt ctcaggtaac tgcgacgtcg taattggtat tgtaaataac     3360

accgtgtacg acccgctcca gccggagctg gactccttca aagaggagct tgacaagtat     3420

tttaagaatc acacttcacc ggatgtagac ctgggggata tttccggcat aaacgcttcc     3480

gtggttaaca tacagaaaga gatagatcga ctgaacgagg tagcgaaaaa cttgaatgag     3540

tctttgatag acctgcaaga attgggaaaa tatgaacaat atattaagtg gccctggtat     3600

atttggcttg gtttcatagc cggtttgatt gccatcgtca tggtaactat aatgctttgt     3660

tgcatgacaa gttgctgctc ttgcctcaaa gggtgctgct cctgtggaag ttgttgcaag     3720

ttcgatgagg atgattctga gccagtgctt aagggtgtca aactgcatta tacg           3774


<210>  98
<211>  4173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct UK Spike variant

<400>  98
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatc ttaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tcagcggaac caacggaacc aaacggttcg ataatccggt tctcccattc      360

aacgatgggg tttacttcgc atctacagaa aaatctaaca taattagagg atggattttt      420

gggactacgc ttgacagtaa gacccaatca ctcttgatcg tgaacaatgc aaccaatgta      480

gtaattaagg tttgcgagtt tcaattttgt aatgatccat ttttgggggt ttaccacaaa      540

aacaataaat cctggatgga atccgaattc agagtgtata gcagcgctaa caattgcaca      600

tttgagtacg tgtcacaacc ttttcttatg gatcttgagg gcaagcaagg gaacttcaaa      660

aatttgaggg agttcgtttt caagaacatc gacggatact ttaagatcta ttctaaacac      720

acccccatta acttggtgcg agatttgcct caaggcttct ctgcacttga accgttggtg      780

gatcttccca ttggcattaa tattactcgg ttccagactt tgttggcact gcatcgctcc      840

tatctcacgc ccggagacag ttcatctgga tggactgcgg gggctgccgc gtattacgtg      900

ggatacctgc agccgcgcac atttcttctt aaatacaacg agaacgggac catcacagat      960

gcagtggatt gcgctcttga ccccctctcc gaaacaaaat gtacgctcaa gtctttcact     1020

gtagagaaag ggatttatca gacatccaat ttccgagtcc agccaacaga gagtatagtg     1080

cggttcccta acatcacaaa tctttgtccg ttcggggaag ttttcaacgc tacacgcttc     1140

gcaagtgtat acgcttggaa tagaaagagg atctctaatt gtgtggcaga ttactctgtg     1200

ctctacaatt ccgcatcttt ctcaaccttc aagtgttacg gagtttcacc tacgaagctg     1260

aacgaccttt gctttactaa tgtatatgca gatagttttg tcatcagggg cgatgaagtt     1320

cgacagatag cgcccggcca gacaggaaag atcgcggact acaattataa actccctgat     1380

gatttcaccg ggtgcgtgat cgcgtggaac tctaataacc tcgactccaa agtaggcggt     1440

aactacaatt acttgtatcg attgtttaga aaatcaaacc ttaaaccgtt cgagcgggat     1500

atctctaccg agatatacca agcaggctct acaccgtgca atggagtcga aggttttaac     1560

tgctacttcc ccttgcaatc atacgggttt cagcctacct acggtgtagg ataccagcct     1620

tacagggttg tggtactttc atttgagctc ctgcacgctc ccgcaactgt ctgtgggccc     1680

aaaaagagca ctaaccttgt taaaaataaa tgcgtcaact ttaacttcaa tggcctcact     1740

ggcaccggcg tgctcactga aagcaataag aaattccttc cttttcagca gtttgggcga     1800

gacatagatg ataccacgga cgcagtacgg gatcctcaaa cccttgaaat ccttgacata     1860

acgccttgct cttttggggg agtaagcgta atcacgcctg gaaccaacac ctccaatcag     1920

gttgctgtgc tgtaccaggg tgtaaactgc accgaggtac cggtagccat tcacgcggat     1980

cagctgactc ccacatggcg agtgtattct acaggtagta atgtgtttca gacccgagca     2040

gggtgtttga taggggcgga gcacgtcaac aactcatacg agtgcgatat acccattggg     2100

gctggtatat gtgcatccta ccagacgcag acgaactctc atgccgccgc tgcgtctgtt     2160

gcatctcaat caattattgc atacactatg tcactggggg ctgagaattc agtagcctac     2220

tctaacaaca gcatcgcgat tcccattaac ttcacaatta gtgtgactac cgagatcctg     2280

ccagtatcca tgactaaaac tagcgtagat tgtactatgt acatctgcgg cgattcaact     2340

gagtgttcaa acctcctctt gcaatacggg tcattttgta cccaattgaa tcgagctctg     2400

accggcatcg cggtcgaaca ggacaaaaat actcaagagg tatttgccca ggtgaagcag     2460

atttacaaaa caccccctat caaggatttc gggggcttca acttcagcca gatactgcca     2520

gacccctcaa aaccgagcaa gcgctccttc atagaagatc ttcttttcaa caaagttacc     2580

ctcgcggatg ctggtttcat taaacagtat ggggactgtc tcggcgacat tgctgctaga     2640

gacctcatct gcgcgcaaaa gttcaatgga cttacggtcc tgccccctct cctcactgat     2700

gaaatgattg ctcaatatac gtccgcgttg ttggcgggaa ctataaccag tgggtggacg     2760

ttcggcgctg gcgccgcgct tcaaatccca tttgcgatgc aaatggcgta tcgcttcaac     2820

ggcatcggag taactcaaaa cgttctgtac gaaaatcaaa aactcattgc gaaccagttt     2880

aattcagcga tcggtaaaat ccaggacagc ctgagctcca cagcgagtgc actcgggaag     2940

ctccaggatg tggtaaatca gaacgctcaa gcgttgaaca cactcgtcaa gcagctgtca     3000

agtaactttg gcgcgatttc atctgtattg aatgacattc tcgctcgcct tgataaggtg     3060

gaagccgaag tccagattga tcgcctgatt actgggcggc ttcagtccct ccaaacatac     3120

gtcactcagc aacttattag agccgccgaa attagggcaa gtgcgaatct ggccgcgaca     3180

aaaatgtctg aatgtgtgct ggggcagagc aagagagtcg atttttgcgg taaggggtat     3240

caccttatgt cttttcctca gtctgcccct cacggagtag tgtttctcca cgttacgtat     3300

gtcccagccc aagagaaaaa ctttaccact gcgccggcta tttgtcatga cggtaaagca     3360

cactttccac gcgaaggtgt gttcgtctcc aacggcaccc actggtttgt aacgcagagg     3420

aacttctacg agcctcagat aattaccacg cacaacacgt tcgtctcagg taactgcgac     3480

gtcgtaattg gtattgtaaa taacaccgtg tacgacccgc tccagccgga gctggactcc     3540

ttcaaagagg agcttgacaa gtattttaag aatcacactt caccggatgt agacctgggg     3600

gatatttccg gcataaacgc ttccgtggtt aacatacaga aagagataga tcgactgaac     3660

gaggtagcga aaaacttgaa tgagtctttg atagacctgc aagaattggg aaaatatgaa     3720

caatatatta agtggccctg gtatatttgg cttggtttca tagccggttt gattgccatc     3780

gtcatggtaa ctataatgct ttgttgcatg acaagttgct gctcttgcct caaagggtgc     3840

tgctcctgtg gaagttgttg caagttcgat gaggatgatt ctgagccagt gcttaagggt     3900

gtcaaactgc attatacgag gtcaattgct atgacgtttc ttgcggttgg aggagttttg     3960

ctcttccttt cggtcaacgt ccatgctgat caaggatgcg ccatcaactt tggcaagaga     4020

gagctcaagt gcggagatgg tatcttcata tttagagact ctgatgactg gctgaacaag     4080

tactcatact atccagaaga tcctgtgaag cttgcatcaa tagtgaaagc ctcttttgaa     4140

gaagggaagt gtggcctaaa ttcagttgac tcc                                  4173


<210>  99
<211>  1391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct UK Spike variant

<400>  99

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg 
            100                 105                 110         


Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser 
        115                 120                 125             


Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu 
    130                 135                 140                 


Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val 
145                 150                 155                 160 


Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly 
                165                 170                 175     


Val Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
            180                 185                 190         


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
        195                 200                 205             


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
    210                 215                 220                 


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
225                 230                 235                 240 


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
                245                 250                 255     


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
            260                 265                 270         


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
        275                 280                 285             


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
    290                 295                 300                 


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
305                 310                 315                 320 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
                325                 330                 335     


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
            340                 345                 350         


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
        355                 360                 365             


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
    370                 375                 380                 


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
385                 390                 395                 400 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
                405                 410                 415     


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
            420                 425                 430         


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
        435                 440                 445             


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
    450                 455                 460                 


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
465                 470                 475                 480 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
                485                 490                 495     


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
            500                 505                 510         


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
        515                 520                 525             


Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
    530                 535                 540                 


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
545                 550                 555                 560 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
                565                 570                 575     


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
            580                 585                 590         


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala 
        595                 600                 605             


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
    610                 615                 620                 


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
625                 630                 635                 640 


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
                645                 650                 655     


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
            660                 665                 670         


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
        675                 680                 685             


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
    690                 695                 700                 


Ala Ser Tyr Gln Thr Gln Thr Asn Ser His Ala Ala Ala Ala Ser Val 
705                 710                 715                 720 


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
                725                 730                 735     


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr 
            740                 745                 750         


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
        755                 760                 765             


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
    770                 775                 780                 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
785                 790                 795                 800 


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
                805                 810                 815     


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
            820                 825                 830         


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
        835                 840                 845             


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
    850                 855                 860                 


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
865                 870                 875                 880 


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
                885                 890                 895     


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
            900                 905                 910         


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
        915                 920                 925             


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
    930                 935                 940                 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
945                 950                 955                 960 


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
                965                 970                 975     


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
            980                 985                 990         


Asn Thr Leu Val Lys Gln Leu Ser  Ser Asn Phe Gly Ala  Ile Ser Ser 
        995                 1000                 1005             


Val Leu  Asn Asp Ile Leu Ala  Arg Leu Asp Lys Val  Glu Ala Glu 
    1010                 1015                 1020             


Val Gln  Ile Asp Arg Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln 
    1025                 1030                 1035             


Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
    1040                 1045                 1050             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1055                 1060                 1065             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1070                 1075                 1080             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1085                 1090                 1095             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1100                 1105                 1110             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1115                 1120                 1125             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1130                 1135                 1140             


Glu Pro  Gln Ile Ile Thr Thr  His Asn Thr Phe Val  Ser Gly Asn 
    1145                 1150                 1155             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1160                 1165                 1170             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1175                 1180                 1185             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1190                 1195                 1200             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1205                 1210                 1215             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1220                 1225                 1230             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1235                 1240                 1245             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1250                 1255                 1260             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1265                 1270                 1275             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1280                 1285                 1290             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr Arg Ser 
    1295                 1300                 1305             


Ile Ala  Met Thr Phe Leu Ala  Val Gly Gly Val Leu  Leu Phe Leu 
    1310                 1315                 1320             


Ser Val  Asn Val His Ala Asp  Gln Gly Cys Ala Ile  Asn Phe Gly 
    1325                 1330                 1335             


Lys Arg  Glu Leu Lys Cys Gly  Asp Gly Ile Phe Ile  Phe Arg Asp 
    1340                 1345                 1350             


Ser Asp  Asp Trp Leu Asn Lys  Tyr Ser Tyr Tyr Pro  Glu Asp Pro 
    1355                 1360                 1365             


Val Lys  Leu Ala Ser Ile Val  Lys Ala Ser Phe Glu  Glu Gly Lys 
    1370                 1375                 1380             


Cys Gly  Leu Asn Ser Val Asp  Ser 
    1385                 1390     


<210>  100
<211>  4173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct South Africa (SA) Spike variant

<400>  100
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatt tcaccacccg aacccagctt      180

cctcccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgctaa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatg atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgaggga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga ggtttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gcatatctcc      840

tatctcacgc ccggagacag ttcatctgga tggactgcgg gggctgccgc gtattacgtg      900

ggatacctgc agccgcgcac atttcttctt aaatacaacg agaacgggac catcacagat      960

gcagtggatt gcgctcttga ccccctctcc gaaacaaaat gtacgctcaa gtctttcact     1020

gtagagaaag ggatttatca gacatccaat ttccgagtcc agccaacaga gagtatagtg     1080

cggttcccta acatcacaaa tctttgtccg ttcggggaag ttttcaacgc tacacgcttc     1140

gcaagtgtat acgcttggaa tagaaagagg atctctaatt gtgtggcaga ttactctgtg     1200

ctctacaatt ccgcatcttt ctcaaccttc aagtgttacg gagtttcacc tacgaagctg     1260

aacgaccttt gctttactaa tgtatatgca gatagttttg tcatcagggg cgatgaagtt     1320

cgacagatag cgcccggcca gacaggaaac atcgcggact acaattataa actccctgat     1380

gatttcaccg ggtgcgtgat cgcgtggaac tctaataacc tcgactccaa agtaggcggt     1440

aactacaatt acttgtatcg attgtttaga aaatcaaacc ttaaaccgtt cgagcgggat     1500

atctctaccg agatatacca agcaggctct acaccgtgca atggagtcaa aggttttaac     1560

tgctacttcc ccttgcaatc atacgggttt cagcctacct acggtgtagg ataccagcct     1620

tacagggttg tggtactttc atttgagctc ctgcacgctc ccgcaactgt ctgtgggccc     1680

aaaaagagca ctaaccttgt taaaaataaa tgcgtcaact ttaacttcaa tggcctcact     1740

ggcaccggcg tgctcactga aagcaataag aaattccttc cttttcagca gtttgggcga     1800

gacatagcgg ataccacgga cgcagtacgg gatcctcaaa cccttgaaat ccttgacata     1860

acgccttgct cttttggggg agtaagcgta atcacgcctg gaaccaacac ctccaatcag     1920

gttgctgtgc tgtaccaggg tgtaaactgc accgaggtac cggtagccat tcacgcggat     1980

cagctgactc ccacatggcg agtgtattct acaggtagta atgtgtttca gacccgagca     2040

gggtgtttga taggggcgga gcacgtcaac aactcatacg agtgcgatat acccattggg     2100

gctggtatat gtgcatccta ccagacgcag acgaactctc ctgccgccgc tgcgtctgtt     2160

gcatctcaat caattattgc atacactatg tcactggggg ttgagaattc agtagcctac     2220

tctaacaaca gcatcgcgat tcccactaac ttcacaatta gtgtgactac cgagatcctg     2280

ccagtatcca tgactaaaac tagcgtagat tgtactatgt acatctgcgg cgattcaact     2340

gagtgttcaa acctcctctt gcaatacggg tcattttgta cccaattgaa tcgagctctg     2400

accggcatcg cggtcgaaca ggacaaaaat actcaagagg tatttgccca ggtgaagcag     2460

atttacaaaa caccccctat caaggatttc gggggcttca acttcagcca gatactgcca     2520

gacccctcaa aaccgagcaa gcgctccttc atagaagatc ttcttttcaa caaagttacc     2580

ctcgcggatg ctggtttcat taaacagtat ggggactgtc tcggcgacat tgctgctaga     2640

gacctcatct gcgcgcaaaa gttcaatgga cttacggtcc tgccccctct cctcactgat     2700

gaaatgattg ctcaatatac gtccgcgttg ttggcgggaa ctataaccag tgggtggacg     2760

ttcggcgctg gcgccgcgct tcaaatccca tttgcgatgc aaatggcgta tcgcttcaac     2820

ggcatcggag taactcaaaa cgttctgtac gaaaatcaaa aactcattgc gaaccagttt     2880

aattcagcga tcggtaaaat ccaggacagc ctgagctcca cagcgagtgc actcgggaag     2940

ctccaggatg tggtaaatca gaacgctcaa gcgttgaaca cactcgtcaa gcagctgtca     3000

agtaactttg gcgcgatttc atctgtattg aatgacattc tctctcgcct tgataaggtg     3060

gaagccgaag tccagattga tcgcctgatt actgggcggc ttcagtccct ccaaacatac     3120

gtcactcagc aacttattag agccgccgaa attagggcaa gtgcgaatct ggccgcgaca     3180

aaaatgtctg aatgtgtgct ggggcagagc aagagagtcg atttttgcgg taaggggtat     3240

caccttatgt cttttcctca gtctgcccct cacggagtag tgtttctcca cgttacgtat     3300

gtcccagccc aagagaaaaa ctttaccact gcgccggcta tttgtcatga cggtaaagca     3360

cactttccac gcgaaggtgt gttcgtctcc aacggcaccc actggtttgt aacgcagagg     3420

aacttctacg agcctcagat aattaccacg gacaacacgt tcgtctcagg taactgcgac     3480

gtcgtaattg gtattgtaaa taacaccgtg tacgacccgc tccagccgga gctggactcc     3540

ttcaaagagg agcttgacaa gtattttaag aatcacactt caccggatgt agacctgggg     3600

gatatttccg gcataaacgc ttccgtggtt aacatacaga aagagataga tcgactgaac     3660

gaggtagcga aaaacttgaa tgagtctttg atagacctgc aagaattggg aaaatatgaa     3720

caatatatta agtggccctg gtatatttgg cttggtttca tagccggttt gattgccatc     3780

gtcatggtaa ctataatgct ttgttgcatg acaagttgct gctcttgcct caaagggtgc     3840

tgctcctgtg gaagttgttg caagttcgat gaggatgatt ctgagccagt gcttaagggt     3900

gtcaaactgc attatacgag gtcaattgct atgacgtttc ttgcggttgg aggagttttg     3960

ctcttccttt cggtcaacgt ccatgctgat caaggatgcg ccatcaactt tggcaagaga     4020

gagctcaagt gcggagatgg tatcttcata tttagagact ctgatgactg gctgaacaag     4080

tactcatact atccagaaga tcctgtgaag cttgcatcaa tagtgaaagc ctcttttgaa     4140

gaagggaagt gtggcctaaa ttcagttgac tcc                                  4173


<210>  101
<211>  1391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct South Africa (SA) Spike variant

<400>  101

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
        275                 280                 285             


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
    290                 295                 300                 


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
305                 310                 315                 320 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
                325                 330                 335     


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
            340                 345                 350         


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
        355                 360                 365             


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
    370                 375                 380                 


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
385                 390                 395                 400 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
                405                 410                 415     


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
            420                 425                 430         


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
        435                 440                 445             


Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
    450                 455                 460                 


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
465                 470                 475                 480 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
                485                 490                 495     


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
            500                 505                 510         


Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
        515                 520                 525             


Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
    530                 535                 540                 


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
545                 550                 555                 560 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
                565                 570                 575     


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
            580                 585                 590         


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
        595                 600                 605             


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
    610                 615                 620                 


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
625                 630                 635                 640 


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
                645                 650                 655     


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
            660                 665                 670         


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
        675                 680                 685             


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
    690                 695                 700                 


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ala Ala Ala Ser Val 
705                 710                 715                 720 


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn 
                725                 730                 735     


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
            740                 745                 750         


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
        755                 760                 765             


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
    770                 775                 780                 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
785                 790                 795                 800 


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
                805                 810                 815     


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
            820                 825                 830         


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
        835                 840                 845             


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
    850                 855                 860                 


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
865                 870                 875                 880 


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
                885                 890                 895     


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
            900                 905                 910         


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
        915                 920                 925             


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
    930                 935                 940                 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
945                 950                 955                 960 


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
                965                 970                 975     


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
            980                 985                 990         


Asn Thr Leu Val Lys Gln Leu Ser  Ser Asn Phe Gly Ala  Ile Ser Ser 
        995                 1000                 1005             


Val Leu  Asn Asp Ile Leu Ser  Arg Leu Asp Lys Val  Glu Ala Glu 
    1010                 1015                 1020             


Val Gln  Ile Asp Arg Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln 
    1025                 1030                 1035             


Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
    1040                 1045                 1050             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1055                 1060                 1065             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1070                 1075                 1080             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1085                 1090                 1095             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1100                 1105                 1110             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1115                 1120                 1125             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1130                 1135                 1140             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1145                 1150                 1155             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1160                 1165                 1170             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1175                 1180                 1185             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1190                 1195                 1200             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1205                 1210                 1215             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1220                 1225                 1230             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1235                 1240                 1245             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1250                 1255                 1260             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1265                 1270                 1275             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1280                 1285                 1290             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr Arg Ser 
    1295                 1300                 1305             


Ile Ala  Met Thr Phe Leu Ala  Val Gly Gly Val Leu  Leu Phe Leu 
    1310                 1315                 1320             


Ser Val  Asn Val His Ala Asp  Gln Gly Cys Ala Ile  Asn Phe Gly 
    1325                 1330                 1335             


Lys Arg  Glu Leu Lys Cys Gly  Asp Gly Ile Phe Ile  Phe Arg Asp 
    1340                 1345                 1350             


Ser Asp  Asp Trp Leu Asn Lys  Tyr Ser Tyr Tyr Pro  Glu Asp Pro 
    1355                 1360                 1365             


Val Lys  Leu Ala Ser Ile Val  Lys Ala Ser Phe Glu  Glu Gly Lys 
    1370                 1375                 1380             


Cys Gly  Leu Asn Ser Val Asp  Ser 
    1385                 1390     


<210>  102
<211>  4182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Construct Brazilian-Japanese (BR) Spike variant

<400>  102
aaggtcatca tgggggcggt acttatatgg gttggcatca acacaagaaa catgacaatg       60

tccatgagca tgatcttggt aggagtgatc atgatgtttt tgtctctagg agttggcgcc      120

gaccagggct gcgcgataaa tttcggtcaa tgtgtgaatt tcaccaaccg aacccagctt      180

ccttccgcct acacgaattc attcacgcgg ggtgtttatt acccggataa agttttccgg      240

tccagtgtcc tgcattcaac ccaagacctc tttctgccat ttttttctaa cgtgacgtgg      300

ttccatgcta tccatgtaag cggaaccaac ggaaccaaac ggttcgataa tccggttctc      360

ccattcaacg atggggttta cttcgcatct acagaaaaat ctaacataat tagaggatgg      420

atttttggga ctacgcttga cagtaagacc caatcactct tgatcgtgaa caatgcaacc      480

aatgtagtaa ttaaggtttg cgagtttcaa ttttgtaatt atccattttt gggggtttat      540

taccacaaaa acaataaatc ctggatggaa tccgaattca gagtgtatag cagcgctaac      600

aattgcacat ttgagtacgt gtcacaacct tttcttatgg atcttgaggg caagcaaggg      660

aacttcaaaa atttgtcgga gttcgttttc aagaacatcg acggatactt taagatctat      720

tctaaacaca cccccattaa cttggtgcga gatttgcctc aaggcttctc tgcacttgaa      780

ccgttggtgg atcttcccat tggcattaat attactcggt tccagacttt gttggcactg      840

catcgctcct atctcacgcc cggagacagt tcatctggat ggactgcggg ggctgccgcg      900

tattacgtgg gatacctgca gccgcgcaca tttcttctta aatacaacga gaacgggacc      960

atcacagatg cagtggattg cgctcttgac cccctctccg aaacaaaatg tacgctcaag     1020

tctttcactg tagagaaagg gatttatcag acatccaatt tccgagtcca gccaacagag     1080

agtatagtgc ggttccctaa catcacaaat ctttgtccgt tcggggaagt tttcaacgct     1140

acacgcttcg caagtgtata cgcttggaat agaaagagga tctctaattg tgtggcagat     1200

tactctgtgc tctacaattc cgcatctttc tcaaccttca agtgttacgg agtttcacct     1260

acgaagctga acgacctttg ctttactaat gtatatgcag atagttttgt catcaggggc     1320

gatgaagttc gacagatagc gcccggccag acaggaacga tcgcggacta caattataaa     1380

ctccctgatg atttcaccgg gtgcgtgatc gcgtggaact ctaataacct cgactccaaa     1440

gtaggcggta actacaatta cttgtatcga ttgtttagaa aatcaaacct taaaccgttc     1500

gagcgggata tctctaccga gatataccaa gcaggctcta caccgtgcaa tggagtcaaa     1560

ggttttaact gctacttccc cttgcaatca tacgggtttc agcctaccta cggtgtagga     1620

taccagcctt acagggttgt ggtactttca tttgagctcc tgcacgctcc cgcaactgtc     1680

tgtgggccca aaaagagcac taaccttgtt aaaaataaat gcgtcaactt taacttcaat     1740

ggcctcactg gcaccggcgt gctcactgaa agcaataaga aattccttcc ttttcagcag     1800

tttgggcgag acatagcgga taccacggac gcagtacggg atcctcaaac ccttgaaatc     1860

cttgacataa cgccttgctc ttttggggga gtaagcgtaa tcacgcctgg aaccaacacc     1920

tccaatcagg ttgctgtgct gtaccagggt gtaaactgca ccgaggtacc ggtagccatt     1980

cacgcggatc agctgactcc cacatggcga gtgtattcta caggtagtaa tgtgtttcag     2040

acccgagcag ggtgtttgat aggggcggag tacgtcaaca actcatacga gtgcgatata     2100

cccattgggg ctggtatatg tgcatcctac cagacgcaga cgaactctcc tgccgccgct     2160

gcgtctgttg catctcaatc aattattgca tacactatgt cactgggggc tgagaattca     2220

gtagcctact ctaacaacag catcgcgatt cccactaact tcacaattag tgtgactacc     2280

gagatcctgc cagtatccat gactaaaact agcgtagatt gtactatgta catctgcggc     2340

gattcaactg agtgttcaaa cctcctcttg caatacgggt cattttgtac ccaattgaat     2400

cgagctctga ccggcatcgc ggtcgaacag gacaaaaata ctcaagaggt atttgcccag     2460

gtgaagcaga tttacaaaac accccctatc aaggatttcg ggggcttcaa cttcagccag     2520

atactgccag acccctcaaa accgagcaag cgctccttca tagaagatct tcttttcaac     2580

aaagttaccc tcgcggatgc tggtttcatt aaacagtatg gggactgtct cggcgacatt     2640

gctgctagag acctcatctg cgcgcaaaag ttcaatggac ttacggtcct gccccctctc     2700

ctcactgatg aaatgattgc tcaatatacg tccgcgttgt tggcgggaac tataaccagt     2760

gggtggacgt tcggcgctgg cgccgcgctt caaatcccat ttgcgatgca aatggcgtat     2820

cgcttcaacg gcatcggagt aactcaaaac gttctgtacg aaaatcaaaa actcattgcg     2880

aaccagttta attcagcgat cggtaaaatc caggacagcc tgagctccac agcgagtgca     2940

ctcgggaagc tccaggatgt ggtaaatcag aacgctcaag cgttgaacac actcgtcaag     3000

cagctgtcaa gtaactttgg cgcgatttca tctgtattga atgacattct ctctcgcctt     3060

gataaggtgg aagccgaagt ccagattgat cgcctgatta ctgggcggct tcagtccctc     3120

caaacatacg tcactcagca acttattaga gccgccgaaa ttagggcaag tgcgaatctg     3180

gccgcgataa aaatgtctga atgtgtgctg gggcagagca agagagtcga tttttgcggt     3240

aaggggtatc accttatgtc ttttcctcag tctgcccctc acggagtagt gtttctccac     3300

gttacgtatg tcccagccca agagaaaaac tttaccactg cgccggctat ttgtcatgac     3360

ggtaaagcac actttccacg cgaaggtgtg ttcgtctcca acggcaccca ctggtttgta     3420

acgcagagga acttctacga gcctcagata attaccacgg acaacacgtt cgtctcaggt     3480

aactgcgacg tcgtaattgg tattgtaaat aacaccgtgt acgacccgct ccagccggag     3540

ctggactcct tcaaagagga gcttgacaag tattttaaga atcacacttc accggatgta     3600

gacctggggg atatttccgg cataaacgct tccttcgtta acatacagaa agagatagat     3660

cgactgaacg aggtagcgaa aaacttgaat gagtctttga tagacctgca agaattggga     3720

aaatatgaac aatatattaa gtggccctgg tatatttggc ttggtttcat agccggtttg     3780

attgccatcg tcatggtaac tataatgctt tgttgcatga caagttgctg ctcttgcctc     3840

aaagggtgct gctcctgtgg aagttgttgc aagttcgatg aggatgattc tgagccagtg     3900

cttaagggtg tcaaactgca ttatacgagg tcaattgcta tgacgtttct tgcggttgga     3960

ggagttttgc tcttcctttc ggtcaacgtc catgctgatc aaggatgcgc catcaacttt     4020

ggcaagagag agctcaagtg cggagatggt atcttcatat ttagagactc tgatgactgg     4080

ctgaacaagt actcatacta tccagaagat cctgtgaagc ttgcatcaat agtgaaagcc     4140

tcttttgaag aagggaagtg tggcctaaat tcagttgact cc                        4182


<210>  103
<211>  1394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct Brazilian-Japanese (BR) Spike variant

<400>  103

Lys Val Ile Met Gly Ala Val Leu Ile Trp Val Gly Ile Asn Thr Arg 
1               5                   10                  15      


Asn Met Thr Met Ser Met Ser Met Ile Leu Val Gly Val Ile Met Met 
            20                  25                  30          


Phe Leu Ser Leu Gly Val Gly Ala Asp Gln Gly Cys Ala Ile Asn Phe 
        35                  40                  45              


Gly Gln Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr 
    50                  55                  60                  


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
65                  70                  75                  80  


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
                85                  90                  95      


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
            100                 105                 110         


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
        115                 120                 125             


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
    130                 135                 140                 


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
145                 150                 155                 160 


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe 
                165                 170                 175     


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
            180                 185                 190         


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
        195                 200                 205             


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
    210                 215                 220                 


Leu Ser Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
225                 230                 235                 240 


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
                245                 250                 255     


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
            260                 265                 270         


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
        275                 280                 285             


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
    290                 295                 300                 


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
305                 310                 315                 320 


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
                325                 330                 335     


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
            340                 345                 350         


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
        355                 360                 365             


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
    370                 375                 380                 


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
385                 390                 395                 400 


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
                405                 410                 415     


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
            420                 425                 430         


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
        435                 440                 445             


Gly Gln Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
    450                 455                 460                 


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
465                 470                 475                 480 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
                485                 490                 495     


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
            500                 505                 510         


Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu 
        515                 520                 525             


Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr 
    530                 535                 540                 


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
545                 550                 555                 560 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
                565                 570                 575     


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
            580                 585                 590         


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
        595                 600                 605             


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
    610                 615                 620                 


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
625                 630                 635                 640 


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
                645                 650                 655     


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
            660                 665                 670         


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
        675                 680                 685             


Ala Glu Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
    690                 695                 700                 


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ala Ala 
705                 710                 715                 720 


Ala Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
                725                 730                 735     


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
            740                 745                 750         


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
        755                 760                 765             


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
    770                 775                 780                 


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
785                 790                 795                 800 


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
                805                 810                 815     


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
            820                 825                 830         


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
        835                 840                 845             


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    850                 855                 860                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
865                 870                 875                 880 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                885                 890                 895     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            900                 905                 910         


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
        915                 920                 925             


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
    930                 935                 940                 


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
945                 950                 955                 960 


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
                965                 970                 975     


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
            980                 985                 990         


Gln Ala Leu Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
        995                 1000                 1005             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1010                 1015                 1020             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1025                 1030                 1035             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1040                 1045                 1050             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Ile Lys Met  Ser Glu Cys 
    1055                 1060                 1065             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1070                 1075                 1080             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1085                 1090                 1095             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1100                 1105                 1110             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1115                 1120                 1125             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1130                 1135                 1140             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1145                 1150                 1155             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1160                 1165                 1170             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1175                 1180                 1185             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1190                 1195                 1200             


Asp Ile  Ser Gly Ile Asn Ala  Ser Phe Val Asn Ile  Gln Lys Glu 
    1205                 1210                 1215             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1220                 1225                 1230             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1235                 1240                 1245             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1250                 1255                 1260             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1265                 1270                 1275             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1280                 1285                 1290             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1295                 1300                 1305             


Thr Arg  Ser Ile Ala Met Thr  Phe Leu Ala Val Gly  Gly Val Leu 
    1310                 1315                 1320             


Leu Phe  Leu Ser Val Asn Val  His Ala Asp Gln Gly  Cys Ala Ile 
    1325                 1330                 1335             


Asn Phe  Gly Lys Arg Glu Leu  Lys Cys Gly Asp Gly  Ile Phe Ile 
    1340                 1345                 1350             


Phe Arg  Asp Ser Asp Asp Trp  Leu Asn Lys Tyr Ser  Tyr Tyr Pro 
    1355                 1360                 1365             


Glu Asp  Pro Val Lys Leu Ala  Ser Ile Val Lys Ala  Ser Phe Glu 
    1370                 1375                 1380             


Glu Gly  Lys Cys Gly Leu Asn  Ser Val Asp Ser 
    1385                 1390                 


