                         SEQUENCE LISTING

<110>  sphingotec GmbH
 
<120>  Anti-ADM-antibodies binding to the free N-terminus for 
       accelerated transition of ADM-Gly to bio-ADM in patients with 
       ADM-Gly/ bio-ADM ratio above a threshold and combination with 
       vitamin C 


<130>  S75367WO

<150>  20159650.9
<151>  2020-02-26

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Tyr Thr Phe Ser Arg Tyr Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ser Ile Val Tyr Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Gln Gly Ser His Ile Pro Tyr Thr 
1               5                   


<210>  6
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 


<210>  7
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 


<210>  8
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 


<210>  9
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 


<210>  10
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 


<210>  11
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Val Leu Leu Ser Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Thr Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  12
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  13
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  14
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys 
            20      


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr 
1               5                   10          


<210>  17
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  17

Tyr Arg Gln Ser Met Asn Gln Gly Ser Arg Ser Asn Gly Cys Arg Phe 
1               5                   10                  15      


Gly Thr Cys 
            


<210>  18
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  18

Cys Thr Phe Gln Lys Leu Ala His Gln Ile Tyr Gln 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  19

Cys Ala Pro Arg Asn Lys Ile Ser Pro Gln Gly Tyr 
1               5                   10          


<210>  20
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  20

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr 
    50          


<210>  21
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  21

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser 
        35                  40                  45              


Pro Gln Gly Tyr Gly 
    50              


<210>  22
<211>  50
<212>  PRT
<213>  Mus musculus

<400>  22

Tyr Arg Gln Ser Met Asn Gln Gly Ser Arg Ser Asn Gly Cys Arg Phe 
1               5                   10                  15      


Gly Thr Cys Thr Phe Gln Lys Leu Ala His Gln Ile Tyr Gln Leu Thr 
            20                  25                  30          


Asp Lys Asp Lys Asp Gly Met Ala Pro Arg Asn Lys Ile Ser Pro Gln 
        35                  40                  45              


Gly Tyr 
    50  


<210>  23
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  23

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


Phe Thr Asp Lys Asp Lys Asp Asn Val Ala 
        35                  40          


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr 
1               5                   10  


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe 
1               5                   10                  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly 
1               5                   10  


<210>  27
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  27

Tyr Arg Gln Ser Met Asn 
1               5       


<210>  28
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys 
1               5                   10                  15      


Arg Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln 
            20                  25                  30          


<210>  29
<211>  40
<212>  PRT
<213>  Mus musculus

<400>  29

Tyr Arg Gln Ser Met Asn Gln Gly Ser Arg Ser Asn Gly Cys Arg Phe 
1               5                   10                  15      


Gly Thr Cys Thr Phe Gln Lys Leu Ala His Gln Ile Tyr Gln Leu Thr 
            20                  25                  30          


Asp Lys Asp Lys Asp Gly Met Ala 
        35                  40  


<210>  30
<211>  31
<212>  PRT
<213>  Mus musculus

<400>  30

Tyr Arg Gln Ser Met Asn Gln Gly Ser Arg Ser Asn Gly Cys Arg Phe 
1               5                   10                  15      


Gly Thr Cys Thr Phe Gln Lys Leu Ala His Gln Ile Tyr Gln Leu 
            20                  25                  30      


<210>  31
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys Lys Trp Asn Lys Trp 
1               5                   10                  15      


Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met Ser Ser Ser Tyr Pro 
            20                  25                  30          


Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala Gln Thr Leu Ile Arg 
        35                  40                  45              


Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro Glu Asp Ser Ser Pro 
    50                  55                  60                  


Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn Asn 
65                  70                  75                  80  


Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr Val 
                85                  90                  95      


Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys Asp 
            100                 105                 110         


Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg Arg 
        115                 120                 125             


Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu Val Ser 
    130                 135                 140                 


Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser Ala 
145                 150                 155                 160 


Pro His Phe Leu 
                


<210>  32
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys Lys Trp Asn Lys Trp 
1               5                   10                  15      


Ala Leu Ser Arg 
            20  


<210>  33
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Leu Arg Met Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys 
1               5                   10                  15      


Ala Gly Pro Ala Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala 
            20                  25                  30          


Ser Arg Ser Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val 
        35                  40                  45              


<210>  34
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu 
1               5                   10                  15      


Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly 
            20                  25                  30          


Ser Ala Pro His Phe Leu 
        35              


<210>  35
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  36
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  37
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  38
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Glu Gly Tyr Glu Tyr Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  39
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg 
            900                 905                 910         


Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala 
        915                 920                 925             


Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu 
    930                 935                 940                 


Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu 
945                 950                 955                 960 


Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970             


<210>  40
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Asp Phe His Met Glu Glu Ala Leu Asp Trp Pro Gly Val 
385                 390                 395                 400 


Tyr Leu Leu Pro Gly Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn 
                405                 410                 415     


Asn Leu Val Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser 
            420                 425                 430         


Phe Asp Ser Lys Phe Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu 
        435                 440                 445             


Glu Asp Thr Ile Leu Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln 
    450                 455                 460                 


Ser Ser Gly Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp 
465                 470                 475                 480 


Lys Asp Gly Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe 
                485                 490                 495     


Lys Leu Asp Pro Asn Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg 
            500                 505                 510         


Ser Met Gln Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp 
        515                 520                 525             


Val Ala Val Asp Pro Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr 
    530                 535                 540                 


Cys Asn Ser Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr 
545                 550                 555                 560 


Gln Trp Gly Glu Glu Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe 
                565                 570                 575     


Thr Val Pro His Ser Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys 
            580                 585                 590         


Val Ala Asp Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr 
        595                 600                 605             


Lys Glu Phe Val Arg Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val 
    610                 615                 620                 


Phe Ala Ile Ser Tyr Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys 
625                 630                 635                 640 


Pro His Phe Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe 
                645                 650                 655     


Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe 
            660                 665                 670         


Asp Met Pro His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile 
        675                 680                 685             


Gly Asp Ala His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys 
    690                 695                 700                 


Leu Glu His Arg Ser Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile 
705                 710                 715                 720 


Lys Glu Ala Glu Ala Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr 
                725                 730                 735     


Ser Ser Glu Leu Gln Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu 
            740                 745                 750         


Pro Gly Ser Gly Val Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile 
        755                 760                 765             


Pro Val Val Val Leu Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys 
    770                 775                 780                 


Ser Arg Ala Phe Gly Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly 
785                 790                 795                 800 


Arg Val Leu Gly Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu 
                805                 810                 815     


Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp 
            820                 825                 830         


Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser 
        835                 840                 845             


Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser 
    850                 855                 860                 


Ser Ser 
865     


<210>  41
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Asp Ser Glu His 
            820                 825                 830         


Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly Arg Phe Arg Gly Lys 
        835                 840                 845             


Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly 
    850                 855                 860                 


Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln 
865                 870                 875                 880 


Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro 
                885                 890                 895     


Leu Pro Ala Leu Ala Pro Ser Ser Ser 
            900                 905 


<210>  42
<211>  887
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Gly Lys Gly Ser 
            820                 825                 830         


Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg Lys Gly Tyr Ser 
        835                 840                 845             


Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser Asp Gln Glu Lys 
    850                 855                 860                 


Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser Ala Pro Leu Pro 
865                 870                 875                 880 


Ala Leu Ala Pro Ser Ser Ser 
                885         


<210>  43
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  44
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe Ala Ser Arg 
            900                 905                 910         


Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr Glu Gly Ser 
        915                 920                 925             


Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu Glu Tyr Ser 
    930                 935                 940                 


Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
945                 950                 955 


<210>  45
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  45

Phe Lys Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr 
1               5                   10                  15      


Arg Pro Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg 
            20                  25                  30          


Met Pro Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser 
        35                  40                  45              


Met Arg Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro 
    50                  55                  60                  


Arg Ala Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn 
65                  70                  75                  80  


Met Pro Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys 
                85                  90                  95      


Thr Asp Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro 
            100                 105                 110         


Thr Arg Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly 
        115                 120                 125             


Ser Lys Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe 
    130                 135                 140                 


Arg Asp Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg 
145                 150                 155                 160 


Leu Pro Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp 
                165                 170                 175     


Thr Val Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys 
            180                 185                 190         


His Tyr Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr 
        195                 200                 205             


His His Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln 
    210                 215                 220                 


Trp Thr Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr 
225                 230                 235                 240 


Pro Val Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala 
                245                 250                 255     


Arg Cys Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly 
            260                 265                 270         


Gly Thr Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met 
        275                 280                 285             


Glu Ala Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala 
    290                 295                 300                 


Pro Asp Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro 
305                 310                 315                 320 


Val Lys Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu 
                325                 330                 335     


Tyr Lys Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu 
            340                 345                 350         


Glu Val Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu 
        355                 360                 365             


Gly Glu Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu 
    370                 375                 380                 


Lys Ala Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val 
385                 390                 395                 400 


Gln Lys Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His 
                405                 410                 415     


Glu Arg Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His 
            420                 425                 430         


Arg Leu Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu 
        435                 440                 445             


Gln Gln Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly 
    450                 455                 460                 


<210>  46
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Phe His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu 
1               5                   10                  15      


Pro Gly Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val 
            20                  25                  30          


Ile Phe His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser 
        35                  40                  45              


Lys Phe Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr 
    50                  55                  60                  


Ile Leu Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly 
65                  70                  75                  80  


Lys Asn Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly 
                85                  90                  95      


Asn Tyr Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp 
            100                 105                 110         


Pro Asn Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln 
        115                 120                 125             


Pro Gly Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val 
    130                 135                 140                 


Asp Pro Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser 
145                 150                 155                 160 


Arg Ile Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly 
                165                 170                 175     


Glu Glu Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro 
            180                 185                 190         


His Ser Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp 
        195                 200                 205             


Arg Glu Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe 
    210                 215                 220                 


Val Arg Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile 
225                 230                 235                 240 


Ser Tyr Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe 
                245                 250                 255     


Gly Asp Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly 
            260                 265                 270         


Glu Ile Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro 
        275                 280                 285             


His Asp Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala 
    290                 295                 300                 


His Thr Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His 
305                 310                 315                 320 


Arg Ser Val 
            


<210>  47
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Pro Leu Ser Val Phe Lys Arg Phe Lys Glu Thr Thr Arg Pro Phe 
1               5                   10                  15      


Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro Val Val Pro Ile Asp Ser 
            20                  25                  30          


Ser Asp Phe Ala Leu Asp Ile Arg Met Pro Gly Val Thr Pro Lys Gln 
        35                  40                  45              


Ser Asp Thr Tyr Phe Cys Met Ser Met Arg Ile Pro Val Asp Glu Glu 
    50                  55                  60                  


Ala Phe Val Ile Asp Phe Lys Pro Arg Ala Ser Met Asp Thr Val His 
65                  70                  75                  80  


His Met Leu Leu Phe Gly Cys Asn Met Pro Ser Ser Thr Gly Ser Tyr 
                85                  90                  95      


Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp Lys Ala Asn Ile Leu Tyr 
            100                 105                 110         


Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg Leu Pro Lys Gly Val Gly 
        115                 120                 125             


Phe Arg Val Gly Gly Glu Thr Gly Ser Lys Tyr Phe Val Leu Gln Val 
    130                 135                 140                 


His Tyr Gly Asp Ile Ser Ala Phe Arg Asp Asn Asn Lys Asp Cys Ser 
145                 150                 155                 160 


Gly Val Ser Leu His Leu Thr Arg Leu Pro Gln Pro Leu Ile Ala Gly 
                165                 170                 175     


Met Tyr Leu Met Met Ser Val Asp Thr Val Ile Pro Ala Gly Glu Lys 
            180                 185                 190         


Val Val Asn Ser Asp Ile Ser Cys His Tyr Lys Asn Tyr Pro Met His 
        195                 200                 205             


Val Phe Ala Tyr Arg Val His Thr His His Leu Gly Lys Val Val Ser 
    210                 215                 220                 


Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr Leu Ile Gly Arg Gln Ser 
225                 230                 235                 240 


Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val Gly His Pro Val Asp Val 
                245                 250                 255     


Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys Val Phe Thr Gly Glu Gly 
            260                 265                 270         


Arg Thr Glu Ala Thr His Ile Gly Gly Thr Ser Ser Asp Glu Met Cys 
        275                 280                 285             


Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala Lys His Ala Val Ser Phe 
    290                 295                 300                 


Met Thr Cys Thr Gln Asn Val Ala Pro Asp Met Phe Arg Thr Ile Pro 
305                 310                 315                 320 


Pro Glu Ala Asn Ile Pro Ile Pro Val Lys Ser Asp Met Val Met Met 
                325                 330                 335     


His Glu His His Lys Glu Thr Glu Tyr Lys Asp Lys Ile Pro Leu Leu 
            340                 345                 350         


Gln Gln Pro Lys Arg Glu Glu Glu Glu Val Leu Asp Gln Gly Asp Phe 
        355                 360                 365             


Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu Arg Glu Asp Val Val His 
    370                 375                 380                 


Val His Lys Tyr Asn Pro Thr Glu Lys Ala Glu Ser Glu Ser Asp Leu 
385                 390                 395                 400 


Val Ala Glu Ile Ala Asn Val Val Gln Lys Lys Asp Leu Gly Arg Ser 
                405                 410                 415     


Asp Ala Arg Glu Gly Ala Glu His Glu Arg Gly Asn Ala Ile Leu Val 
            420                 425                 430         


Arg Asp Arg Ile His Lys Phe His Arg Leu Val Ser Thr Leu Arg Pro 
        435                 440                 445             


Pro Glu Ser Arg Val Phe Ser Leu Gln Gln Pro Pro Pro Gly Glu Gly 
    450                 455                 460                 


Thr Trp Glu Pro Glu His Thr Gly Asp Phe His Met Glu Glu Ala Leu 
465                 470                 475                 480 


Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly Gln Val Ser Gly Val Ala 
                485                 490                 495     


Leu Asp Pro Lys Asn Asn Leu Val Ile Phe His Arg Gly Asp His Val 
            500                 505                 510         


Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe Val Tyr Gln Gln Ile Gly 
        515                 520                 525             


Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu Val Ile Asp Pro Asn Asn 
    530                 535                 540                 


Ala Ala Val Leu Gln Ser Ser Gly Lys Asn Leu Phe Tyr Leu Pro His 
545                 550                 555                 560 


Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr Trp Val Thr Asp Val Ala 
                565                 570                 575     


Leu His Gln Val Phe Lys Leu Asp Pro Asn Asn Lys Glu Gly Pro Val 
            580                 585                 590         


Leu Ile Leu Gly Arg Ser Met Gln Pro Gly Ser Asp Gln Asn His Phe 
        595                 600                 605             


Cys Gln Pro Thr Asp Val Ala Val Asp Pro Gly Thr Gly Ala Ile Tyr 
    610                 615                 620                 


Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile Val Gln Phe Ser Pro Ser 
625                 630                 635                 640 


Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu Ser Ser Gly Ser Ser Pro 
                645                 650                 655     


Leu Pro Gly Gln Phe Thr Val Pro His Ser Leu Ala Leu Val Pro Leu 
            660                 665                 670         


Leu Gly Gln Leu Cys Val Ala Asp Arg Glu Asn Gly Arg Ile Gln Cys 
        675                 680                 685             


Phe Lys Thr Asp Thr Lys Glu Phe Val Arg Glu Ile Lys His Ser Ser 
    690                 695                 700                 


Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr Ile Pro Gly Leu Leu Phe 
705                 710                 715                 720 


Ala Val Asn Gly Lys Pro His Phe Gly Asp Gln Glu Pro Val Gln Gly 
                725                 730                 735     


Phe Val Met Asn Phe Ser Asn Gly Glu Ile Ile Asp Ile Phe Lys Pro 
            740                 745                 750         


Val Arg Lys His Phe Asp Met Pro His Asp Ile Val Ala Ser Glu Asp 
        755                 760                 765             


Gly Thr Val Tyr Ile Gly Asp Ala His Thr Asn Thr Val Trp Lys Phe 
    770                 775                 780                 


Thr Leu Thr Glu Lys Leu Glu His Arg Ser Val Lys Lys Ala Gly Ile 
785                 790                 795                 800 


Glu Val Gln Glu Ile Lys Glu Ala Glu Ala Val Val Gly Ser 
                805                 810                 


<210>  48
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys 
1               5                   10                  15      


Asp Lys Asp Asn Val Ala 
            20     


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys Asp 
1               5                   10                   


