                         SEQUENCE LISTING

<110>  Quell Therapeutics Limited
 
<120>  CHIMERIC RECEPTORS FOR USE IN ENGINEERED CELLS

<130>  27.130.147002/03

<150>  GB2002622.5
<151>  2020-02-25

<150>  GB2002620.9
<151>  2020-02-25

<160>  205   

<170>  PatentIn version 3.5

<210>  1
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 266 to 551 of interleukin-2 receptor beta  (IL2RB), 
       NP_000869.1 (IL2Rbeta endodomain)

<400>  1

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  2
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 265 to 459 of interleukin-7 receptor-alpha 
       (IL7R-alpha), NP_002176.2

<400>  2

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  3
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 292 to 521 of interleukin-9 receptor (IL9R), 
       NP_002177.2

<400>  3

Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn Val Pro Ser 
1               5                   10                  15      


Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn Gly Asn Phe 
            20                  25                  30          


Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu Ser Gln Asp 
        35                  40                  45              


Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val Gln Glu Ala 
    50                  55                  60                  


Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys Ser Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro Gly Asn Leu 
                85                  90                  95      


Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp Arg Val Gln 
            100                 105                 110         


Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr Ser Leu Thr 
        115                 120                 125             


Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys Tyr Gly Gly 
145                 150                 155                 160 


Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser Gly Pro Ile 
                165                 170                 175     


Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly Leu Glu Thr 
            180                 185                 190         


Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln Arg Pro Gly 
        195                 200                 205             


Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val Leu Ser Lys 
    210                 215                 220                 


Ala Arg Ser Trp Thr Phe 
225                 230 


<210>  4
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 257 to 825 of interleukin-4 receptor-alpha 
       (IL4R-alpha), NPJD00409.1

<400>  4

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  5
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 461 to 897 of IL3RB, NP_000386.1

<400>  5

Arg Phe Cys Gly Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu 
1               5                   10                  15      


Lys Ile Pro Asn Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala 
            20                  25                  30          


Glu Leu Trp Pro Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro 
        35                  40                  45              


Pro His Gln Gly Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val 
    50                  55                  60                  


Phe Pro Val Gly Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu 
65                  70                  75                  80  


Asp Pro Lys His Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro 
                85                  90                  95      


Ala Ala Ser Asp Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly 
            100                 105                 110         


Pro Pro Ala Ala Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp 
        115                 120                 125             


Phe Asn Gly Pro Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp 
    130                 135                 140                 


Ile Leu Gly Gln Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser 
145                 150                 155                 160 


Pro Pro Pro Gly Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln 
                165                 170                 175     


Val Gln Leu Val Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val 
            180                 185                 190         


Glu Val Glu Arg Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly 
    210                 215                 220                 


Gly Gln Asp Gln Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly 
225                 230                 235                 240 


Asp Thr Glu Asp Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp 
                245                 250                 255     


Leu Val Phe Thr Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro 
            260                 265                 270         


Ser Leu Gly Leu Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu 
        275                 280                 285             


Ala Ser Gly Pro Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu 
    290                 295                 300                 


Gly Tyr Val Glu Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro 
305                 310                 315                 320 


Arg Asn Asn Pro Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro 
                325                 330                 335     


Gly Glu Arg Pro Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly 
            340                 345                 350         


Leu Leu Val Leu Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu 
        355                 360                 365             


Gly Pro Gly Pro Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro 
    370                 375                 380                 


Gly Pro Glu Ile Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro 
385                 390                 395                 400 


Pro Gly Gln Ala Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala 
                405                 410                 415     


Leu Lys Gln Gln Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys 
            420                 425                 430         


Pro Gly Glu Val Cys 
        435         


<210>  6
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 314 to 502 of IL17RB, NP_061195.2

<400>  6

Arg His Glu Arg Ile Lys Lys Thr Ser Phe Ser Thr Thr Thr Leu Leu 
1               5                   10                  15      


Pro Pro Ile Lys Val Leu Val Val Tyr Pro Ser Glu Ile Cys Phe His 
            20                  25                  30          


His Thr Ile Cys Tyr Phe Thr Glu Phe Leu Gln Asn His Cys Arg Ser 
        35                  40                  45              


Glu Val Ile Leu Glu Lys Trp Gln Lys Lys Lys Ile Ala Glu Met Gly 
    50                  55                  60                  


Pro Val Gln Trp Leu Ala Thr Gln Lys Lys Ala Ala Asp Lys Val Val 
65                  70                  75                  80  


Phe Leu Leu Ser Asn Asp Val Asn Ser Val Cys Asp Gly Thr Cys Gly 
                85                  90                  95      


Lys Ser Glu Gly Ser Pro Ser Glu Asn Ser Gln Asp Leu Phe Pro Leu 
            100                 105                 110         


Ala Phe Asn Leu Phe Cys Ser Asp Leu Arg Ser Gln Ile His Leu His 
        115                 120                 125             


Lys Tyr Val Val Val Tyr Phe Arg Glu Ile Asp Thr Lys Asp Asp Tyr 
    130                 135                 140                 


Asn Ala Leu Ser Val Cys Pro Lys Tyr His Leu Met Lys Asp Ala Thr 
145                 150                 155                 160 


Ala Phe Cys Ala Glu Leu Leu His Val Lys Gln Gln Val Ser Ala Gly 
                165                 170                 175     


Lys Arg Ser Gln Ala Cys His Asp Gly Cys Cys Ser Leu 
            180                 185                 


<210>  7
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R-alpha 2Y truncated

<400>  7

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
65                  70                  75                  80  


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
                85                  90      


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Phe or Leu

<400>  8

Tyr Xaa Xaa Xaa 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  9

Tyr Cys Thr Phe 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  10

Tyr Phe Phe Phe 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  11

Tyr Leu Ser Leu 
1               


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5 association motif

<400>  12

Tyr Leu Ser Leu Gln 
1               5   


<210>  13
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  13

Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
1               5                   10                  15      


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
            20                  25                  30          


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
        35                  40                  45              


Pro Leu Glu Val Leu Glu Arg Asp Lys 
    50                  55          


<210>  14
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  14

Asn Pro Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser 
1               5                   10                  15      


Gly His Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser 
            20                  25                  30          


Val Asn Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr 
        35                  40                  45  


<210>  15
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  15

Gly Tyr Ile Cys Leu Arg Asn Ser Leu Pro Lys Val Leu Asn Phe His 
1               5                   10                  15      


Asn Phe Leu Ala Trp Pro Phe Pro Asn Leu Pro Pro Leu Glu Ala Met 
            20                  25                  30          


Asp Met Val Glu Val Ile Tyr Ile Asn Arg 
        35                  40          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  16

Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile Ser Val 
1               5                   10                  15      


Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr Val Ser 
            20                  25                  30          


Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu 
        35                  40          


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  17

Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe Lys Lys Pro Ser 
1               5                   10                  15      


Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu Thr Gln Asp Thr 
            20                  25                  30          


Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys 
        35                  40              


<210>  18
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  18

Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile Leu Ile 
1               5                   10                  15      


Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu Lys Ile 
            20                  25                  30          


Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser 
        35                  40                  45  


<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK1-binding motif

<400>  19

Arg Tyr Val Thr Lys Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln 
1               5                   10                  15      


Arg Val Leu Thr Phe Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu 
            20                  25                  30          


Ile Pro Val Phe Asp Leu Ser Gly Pro 
        35                  40      


<210>  20
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  20

Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
1               5                   10                  15      


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
            20                  25                  30          


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn 
        35                  40              


<210>  21
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  21

Tyr Trp Phe His Thr Pro Pro Ser Ile Pro Leu Gln Ile Glu Glu Tyr 
1               5                   10                  15      


Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu Ala Leu Asp Lys Asp Ser 
            20                  25                  30          


Ser Pro Lys Asp Asp Val Trp Asp Ser Val Ser Ile Ile Ser Phe Pro 
        35                  40                  45              


Glu 
    


<210>  22
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK2-binding motif

<400>  22

Tyr Ala Phe Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe 
1               5                   10                  15      


Leu Gly His Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu 
            20                  25                  30          


Ser Asp Glu Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp 
        35                  40                  45              


Ser Glu Ser 
    50      


<210>  23
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated IL2Rbeta endodomain - Y510

<400>  23

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  24
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated IL2Rbeta endodomain - Y510 & Y392

<400>  24

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Asp Ala Tyr Cys Thr Phe Pro Ser 
65                  70                  75                  80  


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
                85                  90                  95      


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
            100                 105                 110         


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
        115                 120                 125             


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
    130                 135                 140                 


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
145                 150                 155                 160 


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
                165                 170                 175     


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
            180                 185                 190         


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205             


<210>  25
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3-binding motif

<400>  25

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile 
    50          


<210>  26
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JAK3-binding motif

<400>  26

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular signaling domain of human CD3 zeta chain

<400>  27

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  28
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 signaling domain

<400>  28

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  29
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 signaling domain

<400>  29

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  30
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 signalling domain

<400>  30

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB signalling domain

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS signalling domain

<400>  32

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  33
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNFRSF25 signalling domain

<400>  33

Thr Tyr Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala 
1               5                   10                  15      


Asp Glu Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu 
            20                  25                  30          


Ser Pro Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser 
        35                  40                  45              


Glu Lys Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly 
    50                  55                  60                  


Tyr Pro Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp 
65                  70                  75                  80  


Asp Gln Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu 
                85                  90                  95      


Ser Pro Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys 
        115                 120                 125             


Glu Phe Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val 
    130                 135                 140                 


Glu Val Glu Ile Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys 
145                 150                 155                 160 


Arg Trp Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala 
                165                 170                 175     


Leu Glu Arg Met Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg 
            180                 185                 190         


Leu Gln Arg Gly Pro 
        195         


<210>  34
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu 
            180                 185                 190         


Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly 
                245     


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28 transmembrane

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  36
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28 hinge and transmembrane sequence

<400>  36

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  37
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane and intracellular portion of human CD28

<400>  37

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD28

<400>  38

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-Myc tag

<400>  39

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  40
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge/transmembrane domain with integrated c-Myc tag

<400>  40

Ile Glu Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn 
1               5                   10                  15      


Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys 
            20                  25                  30          


Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val 
        35                  40                  45              


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    50                  55                  60                  


Phe Ile Ile Phe Trp Val 
65                  70  


<210>  41
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  42
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor (CAR) containing HLA-A2 scFV, c-Myc 
       tag, CD28, IL2RB-Y510, CD3 zeta endodomain

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Asn Cys Arg 
    370                 375                 380                 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
385                 390                 395                 400 


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
                405                 410                 415     


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
            420                 425                 430         


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
        435                 440                 445             


Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
    450                 455                 460                 


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Thr Arg Gly Gly 
            580                 585                 590         


Gly Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
        595                 600                 605             


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
    610                 615                 620                 


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
625                 630                 635                 640 


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
                645                 650                 655     


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
            660                 665                 670         


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
        675                 680                 685             


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
    690                 695                 700                 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
705                 710                 715                 720 


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
                725                 730                 735     


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
            740                 745                 750         


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
        755                 760                 765             


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
    770                 775                 780                 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
785                 790                 795                 800 


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
                805                 810                 815     


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
            820                 825                 830         


Tyr Lys 
        


<210>  43
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR containing HLA-A2 scFV, c-Myc tag, CD28, IL2RG-T52, 
       IL2RB-Y510, CD3 zeta endodomain

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr 
    370                 375                 380                 


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
385                 390                 395                 400 


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
                405                 410                 415     


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
            420                 425                 430         


Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys 
        435                 440                 445             


Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His 
    450                 455                 460                 


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
465                 470                 475                 480 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
                485                 490                 495     


Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr 
            500                 505                 510         


Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg 
        515                 520                 525             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
    530                 535                 540                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
545                 550                 555                 560 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                565                 570                 575     


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
            580                 585                 590         


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
        595                 600                 605             


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
    610                 615                 620                 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
625                 630                 635                 


<210>  44
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR containing HLA-A2 scFV, c-Myc tag, CD28, IL2RG-T52, IL7RA-2Y,
       CD3 zeta endodomain

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Asp Asn Glu Lys 
        275                 280                 285             


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
    290                 295                 300                 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr 
    370                 375                 380                 


Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu 
385                 390                 395                 400 


Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala 
                405                 410                 415     


Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu 
            420                 425                 430         


Ile Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His 
        435                 440                 445             


Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn 
    450                 455                 460                 


Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val 
465                 470                 475                 480 


Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr 
                485                 490                 495     


Phe Pro Gln Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu 
            500                 505                 510         


Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Arg Val Lys Phe 
        515                 520                 525             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    530                 535                 540                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
545                 550                 555                 560 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                565                 570                 575     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            580                 585                 590         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        595                 600                 605             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    610                 615                 620                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
625                 630                 635                 640 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                645                 650                 655     


Gly 
    


<210>  45
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  illustrative endodomain sequence comprising CD28, IL2RG-T52, 
       IL2RB-Y510, CD3 zeta signalling domains

<400>  45

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg Ile 
        35                  40                  45              


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
    50                  55                  60                  


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Asn Cys Arg 
                85                  90                  95      


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
            100                 105                 110         


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
        115                 120                 125             


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
    130                 135                 140                 


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
145                 150                 155                 160 


Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
                165                 170                 175     


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val Lys Phe Ser 
            180                 185                 190         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        195                 200                 205             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    210                 215                 220                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
225                 230                 235                 240 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                245                 250                 255     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            260                 265                 270         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        275                 280                 285             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    290                 295                 


<210>  46
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide - cleavage domain

<400>  46

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide - cleavage domain

<400>  47

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  48
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide - cleavage domain

<400>  48

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide - cleavage domain

<400>  49

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin site - cleavage domain


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Arg Xaa Xaa Arg 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin site - cleavage domain

<400>  51

Arg Arg Lys Arg 
1               


<210>  52
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  53
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  illustrative endodomain sequence comprising CD28, IL2RG-T52, 
       IL7RA-2Y, CD3 zeta signalling domains

<400>  53

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg Ile 
        35                  40                  45              


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
    50                  55                  60                  


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Lys Lys Arg 
                85                  90                  95      


Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu 
            100                 105                 110         


Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn 
        115                 120                 125             


Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
    130                 135                 140                 


Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln 
145                 150                 155                 160 


Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr 
                165                 170                 175     


Met Ser Ser Phe Tyr Gln Asn Gln Arg Val Lys Phe Ser Arg Ser Ala 
            180                 185                 190         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        195                 200                 205             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    210                 215                 220                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
225                 230                 235                 240 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                245                 250                 255     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            260                 265                 270         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        275                 280                 285             


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser 
    290                 295                 300                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
305                 310                 315         


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  54

Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Ala 
        35                  40                  45              


Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val 
        115                 120 


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  56
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  57
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy domain

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr 
        115         


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  58

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105             


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  59

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  60

Asp Ile Val Leu Met Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Arg Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  61

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  62

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Glu Thr His Leu Asp Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  63

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  64

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  65

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  66

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Thr Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asp Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  67

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  68

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  69

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  70

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  71
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  71

Asp Val Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Gly Ile Ser Asn Tyr 
            20                  25                  30          


Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light domain

<400>  72

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Arg Gly Ser Asn Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Thr Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  73
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile 
145                 150                 155                 160 


Ser His Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn 
    210                 215                 220                 


Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235             


<210>  74
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Met Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


His Gly Ile Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Tyr Pro Pro Thr Phe Gly Arg Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  75
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  76
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Glu Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Glu Thr His Leu Asp Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Thr Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  77
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Ile Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  78
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Ser Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  79
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asn Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  80
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  80

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Thr Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
        195                 200                 205             


Ile Asp Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr His Thr Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  81
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  82
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser 
145                 150                 155                 160 


Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Phe Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  83
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
                165                 170                 175     


Ala Pro Thr Leu Leu Ile Phe Ala Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
    210                 215                 220                 


Asp Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  84
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
                165                 170                 175     


Ala Pro Thr Leu Leu Ile Tyr Lys Ala Ser Asn Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Ser Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  85
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  85

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


His Gly Ile Ser Asn Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
225                 230                 235                 240 


Lys 
    


<210>  86
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigen binding domain sequence which is capable of binding to 
       HLA-A2

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr 
    130                 135                 140                 


Leu Ser Ala Tyr Val Gly Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Arg Gly Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Thr Ser Thr Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 


Asp Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
225                 230                 235                 240 


<210>  87
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain, CD8alpha transmembrane

<400>  87

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  88
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha hinge domain and CD28 transmembrane domain

<400>  88

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val 
        35                  40                  45              


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
    50                  55                  60                  


Val Ala Phe Ile Ile Phe Trp Val 
65                  70          


<210>  89
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain and CD8alpha transmembrane domain

<400>  89

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
        35                  40                  45              


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
    50                  55                  60  


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL heavy chain variable region (VH) complementarity determining 
       region (CDR), GL VH CDR1

<400>  90

Asp Tyr Gly Met His 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VH CDR2

<400>  91

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VH CDR3

<400>  92

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR1

<400>  93

Asp Tyr Gly Met His 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR2

<400>  94

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VH CDR3

<400>  95

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
1               5                   10                  


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR1

<400>  96

Asp Tyr Gly Met His 
1               5   


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR2

<400>  97

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VH CDR3

<400>  98

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR1

<400>  99

Asp Tyr Gly Met His 
1               5   


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR2

<400>  100

Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VH CDR3

<400>  101

Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Phe Asp Leu 
1               5                   10                  


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL light chain variable region (VL) CDR1

<400>  102

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VL CDR2

<400>  103

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GL VL CDR3

<400>  104

Gln Gln Tyr Asp Asn Leu Pro Pro Thr 
1               5                   


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR1

<400>  105

Gln Ser Ser Leu Asp Ile Ser His Tyr Leu Asn 
1               5                   10      


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR2

<400>  106

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PB2 VL CDR3

<400>  107

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR1

<400>  108

Arg Ala Ser His Gly Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR2

<400>  109

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PC4 VL CDR3

<400>  110

Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
1               5                   


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR1

<400>  111

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR2

<400>  112

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3PF12 VL CDR3

<400>  113

Gln Gln Tyr Ser Ser Phe Pro Leu Thr 
1               5                   


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR1

<400>  114

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR2

<400>  115

Asp Glu Thr His Leu Asp Ser 
1               5           


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C12 VL CDR3

<400>  116

Gln Gln Tyr Asp Ser Leu Pro Pro Thr 
1               5                   


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR1

<400>  117

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR2

<400>  118

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 VL CDR3

<400>  119

Gln Gln Tyr Asp Asn Leu Pro Ile Thr 
1               5                   


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR1

<400>  120

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR2

<400>  121

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H10 VL CDR3

<400>  122

Gln Gln Tyr Asp Asn Leu Pro Ser Thr 
1               5                   


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR1

<400>  123

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR2

<400>  124

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B8 VL CDR3

<400>  125

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR1

<400>  126

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR2

<400>  127

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D2 VL CDR3

<400>  128

Gln Gln Tyr His Thr Tyr Pro Leu Thr 
1               5                   


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR1

<400>  129

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR2

<400>  130

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B10 VL CDR3

<400>  131

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR1

<400>  132

Arg Thr Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR2

<400>  133

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A9 VL CDR3

<400>  134

Gln Gln Phe Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR1

<400>  135

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR2

<400>  136

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B12 VL CDR3

<400>  137

Leu Gln Asp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR1

<400>  138

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR2

<400>  139

Lys Ala Ser Asn Leu Gln Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4 VL CDR3

<400>  140

Gln Gln Tyr Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR1

<400>  141

Arg Ala Ser His Gly Ile Ser Asn Tyr Phe Ala 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR2

<400>  142

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D4 VL CDR3

<400>  143

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR1

<400>  144

Arg Ala Ser Arg Gly Ser Asn Tyr Leu Ala 
1               5                   10  


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR2

<400>  145

Ala Thr Ser Thr Leu Gln Ser 
1               5           


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3 VL CDR3

<400>  146

Gln Gln Tyr Asp Ser Tyr Pro Pro Thr 
1               5                   


<210>  147
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant of FOXP3

<400>  147

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Glu Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  148
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant of FOXP3

<400>  148

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ala Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  149
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant of FOXP3

<400>  149

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Glu Gln Arg Pro Ala Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  150
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N and C terminal FOXP3 truncation

<400>  150

Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met Pro Pro Ser 
1               5                   10                  15      


Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala Pro Ser Gly 
            20                  25                  30          


Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu Gln Asp Arg 
        35                  40                  45              


Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His Ala Arg Thr 
    50                  55                  60                  


Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met Ile Ser Leu 
65                  70                  75                  80  


Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys Ala Arg Pro 
                85                  90                  95      


Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val Ser Arg 
            100                 105                 110         


Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala Pro Arg Lys 
        115                 120                 125             


Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro Leu Leu Ala 
    130                 135                 140                 


Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe Glu Glu Pro 
145                 150                 155                 160 


Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu Asp Glu Lys 
                165                 170                 175     


Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser Leu Glu 
            180                 185                 190         


Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln Ala His 
        195                 200                 205             


Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser 
    210                 215                 220                 


Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val 
225                 230                 235                 240 


Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala 
                245                 250                 255     


Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu 
            260                 265                 270         


Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro 
        275                 280                 285             


Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu 
    290                 295                 300                 


Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe 
305                 310                 315                 320 


Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His 
                325                 330                 335     


Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly 
            340                 345                 350         


Ala Val Trp Thr Val Asp Glu Leu Glu Phe 
        355                 360         


<210>  151
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of FOXP3

<400>  151

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Val Glu Glu Leu Ser Ala Met Gln Ala His Leu Ala 
                245                 250                 255     


Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val Ala Ser Ser Asp Lys 
            260                 265                 270         


Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln Gly Pro Val Val Pro 
        275                 280                 285             


Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser Leu Phe Ala Val Arg 
    290                 295                 300                 


Arg His Leu Trp Gly Ser His Gly Asn Ser Thr Phe Pro Glu Phe Leu 
305                 310                 315                 320 


His Asn Met Asp Tyr Phe Lys Phe His Asn Met Arg Pro Pro Phe Thr 
                325                 330                 335     


Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu Ala Pro Glu Lys Gln 
            340                 345                 350         


Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr Arg Met Phe Ala Phe 
        355                 360                 365             


Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala Ile Arg His Asn Leu 
    370                 375                 380                 


Ser Leu His Lys Cys Phe Val Arg Val Glu Ser Glu Lys Gly Ala Val 
385                 390                 395                 400 


Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys Arg Ser Gln Arg Pro 
                405                 410                 415     


Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro Glu Gly Arg Gly Ser Leu 
            420                 425                 430         


Leu Thr Cys Gly Asp Val Glu Glu Asn 
        435                 440     


<210>  152
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  152
atgcccaacc ccaggcctgg caagccctcg gccccttcct tggcccttgg cccatcccca       60

ggagcctcgc ccagctggag ggctgcaccc aaagcctcag acctgctggg ggcccggggc      120

ccagggggaa ccttccaggg ccgagatctt cgaggcgggg cccatgcctc ctcttcttcc      180

ttgaacccca tgccaccatc gcagctgcag ctgcccacac tgcccctagt catggtggca      240

ccctccgggg cacggctggg ccccttgccc cacttacagg cactcctcca ggacaggcca      300

catttcatgc accagctctc aacggtggat gcccacgccc ggacccctgt gctgcaggtg      360

caccccctgg agagcccagc catgatcagc ctcacaccac ccaccaccgc cactggggtc      420

ttctccctca aggcccggcc tggcctccca cctgggatca acgtggccag cctggaatgg      480

gtgtccaggg agccggcact gctctgcacc ttcccaaatc ccagtgcacc caggaaggac      540

agcacccttt cggctgtgcc ccagagctcc tacccactgc tggcaaatgg tgtctgcaag      600

tggcccggat gtgagaaggt cttcgaagag ccagaggact tcctcaagca ctgccaggcg      660

gaccatcttc tggatgagaa gggcagggca caatgtctcc tccagagaga gatggtacag      720

tctctggagc agcagctggt gctggagaag gagaagctga gtgccatgca ggcccacctg      780

gctgggaaaa tggcactgac caaggcttca tctgtggcat catccgacaa gggctcctgc      840

tgcatcgtag ctgctggcag ccaaggccct gtcgtcccag cctggtctgg cccccgggag      900

gcccctgaca gcctgtttgc tgtccggagg cacctgtggg gtagccatgg aaacagcaca      960

ttcccagagt tcctccacaa catggactac ttcaagttcc acaacatgcg accccctttc     1020

acctacgcca cgctcatccg ctgggccatc ctggaggctc cagagaagca gcggacactc     1080

aatgagatct accactggtt cacacgcatg tttgccttct tcagaaacca tcctgccacc     1140

tggaagaacg ccatccgcca caacctgagt ctgcacaagt gctttgtgcg ggtggagagc     1200

gagaaggggg ctgtgtggac cgtggatgag ctggagttcc gcaagaaacg gagccagagg     1260

cccagcaggt gttccaaccc tacacctggc ccctga                               1296


<210>  153
<211>  1352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence encoding FOXP3 variant

<400>  153
gaattcgtcg acatgcccaa ccccagaccc ggcaagcctt ctgccccttc tctggccctg       60

ggaccatctc ctggcgcctc cccatcttgg agagccgccc ctaaagccag cgatctgctg      120

ggagctagag gccctggcgg cacattccag ggcagagatc tgagaggcgg agcccacgcc      180

tctagcagca gcctgaatcc catgccccct agccagctgc agctgcctac actgcctctc      240

gtgatggtgg cccctagcgg agctagactg ggccctctgc ctcatctgca ggctctgctg      300

caggaccggc cccactttat gcaccagctg agcaccgtgg acgcccacgc cagaacacct      360

gtgctgcagg tgcaccccct ggaaagccct gccatgatca gcctgacccc tccaaccaca      420

gccaccggcg tgttcagcct gaaggccaga cctggactgc cccctggcat caatgtggcc      480

agcctggaat gggtgtcccg cgaacctgcc ctgctgtgca ccttccccaa tcctagcgcc      540

cccagaaagg acagcacact gtctgccgtg ccccagagca gctatcccct gctggctaac      600

ggcgtgtgca agtggcctgg ctgcgagaag gtgttcgagg aacccgagga cttcctgaag      660

cactgccagg ccgaccatct gctggacgag aaaggcagag cccagtgcct gctgcagcgc      720

gagatggtgc agtccctgga acagcagctg gtgctggaaa aagaaaagct gagcgccatg      780

caggcccacc tggccggaaa gatggccctg acaaaagcca gcagcgtggc cagctccgac      840

aagggcagct gttgtatcgt ggccgctggc agccagggac ctgtggtgcc tgcttggagc      900

ggacctagag aggcccccga tagcctgttt gccgtgcgga gacacctgtg gggcagccac      960

ggcaactcta ccttccccga gttcctgcac aacatggact acttcaagtt ccacaacatg     1020

aggcccccct tcacctacgc caccctgatc agatgggcca ttctggaagc ccccgagaag     1080

cagcggaccc tgaacgagat ctaccactgg tttacccgga tgttcgcctt cttccggaac     1140

caccccgcca cctggaagaa cgccatccgg cacaatctga gcctgcacaa gtgcttcgtg     1200

cgggtggaaa gcgagaaggg cgccgtgtgg acagtggacg agctggaatt tcggaagaag     1260

cggtcccaga ggcccagccg gtgtagcaat cctacacctg gccctgaggg cagaggaagt     1320

ctgctaacat gcggtgacgt cgaggagaat cc                                   1352


<210>  154
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR endodomain sequence

<400>  154

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg Ile 
        35                  40                  45              


Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn 
    50                  55                  60                  


Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Cys Arg Asn 
            100                 105                 110         


Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro 
        115                 120                 125             


Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln 
    130                 135                 140                 


Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly 
145                 150                 155                 160 


Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val 
                165                 170                 175     


Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val Arg Val Lys Phe Ser Arg 
        195                 200                 205             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    210                 215                 220                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
225                 230                 235                 240 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                245                 250                 255     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            260                 265                 270         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        275                 280                 285             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    290                 295                 300                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  155

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  156

Gly Gly Gly Gly Ser 
1               5   


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  157

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  158
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  159

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  160

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  161

Glu Thr Ser Gly Gly Gly Gly Ser Arg Leu 
1               5                   10  


<210>  162
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  162

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  163
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  163

Gly Gly Gly Ser 
1               


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  164

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  165

Gly Gly Gly Gly Gly Gly Ser 
1               5           


<210>  166
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  166

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  167
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  167

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  168

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  169
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  169

Ser Gly Gly Gly Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10                  15      


<210>  170
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  170

Ser Gly Gly Gly Leu Leu Leu Leu Leu Leu Leu Leu Gly Gly Gly Ser 
1               5                   10                  15      


<210>  171
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  171

Ser Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gly Ser 
1               5                   10                  15      


<210>  172
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  172

Ser Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Gly Gly Gly Ser 
            20                  


<210>  173
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  173

Ser Gly Ala Leu Gly Gly Leu Ala Leu Ala Gly Leu Leu Leu Ala Gly 
1               5                   10                  15      


Leu Gly Leu Gly Ala Ala Gly Ser 
            20                  


<210>  174
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  174

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Pro Ala Arg 
1               5                   10                  


<210>  175
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  175

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Pro Ala Arg Ser Leu 
1               5                   10                  15      


Ser Leu Ser Pro Gly Gly Gly Gly Gly 
            20                  25  


<210>  176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  176

Gly Ser Ser Gly Ser Ser 
1               5       


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  177

Gly Ser Ser Ser Ser Ser Ser 
1               5           


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  178

Gly Gly Ser Ser Ser Ser 
1               5       


<210>  179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  179

Gly Ser Ser Ser Ser Ser 
1               5       


<210>  180
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  180

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  181
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a hinge

<400>  181

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  182
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control Construct

<400>  182

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


<210>  183
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CI (Construct 1)

<400>  183

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
                405                 410                 415     


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            420                 425                 430         


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        435                 440                 445             


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    450                 455                 460                 


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
465                 470                 475                 480 


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
545                 550                 555                 560 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                565                 570                 575     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            580                 585                 590         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605             


<210>  184
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CII (Construct 2)

<400>  184

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys 
    450                 455                 460                 


Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
465                 470                 475                 480 


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
                485                 490                 495     


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
            500                 505                 510         


Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu 
        515                 520                 525             


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
    530                 535                 540                 


Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
545                 550                 555                 560 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                565                 570                 575     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            580                 585                 590         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        595                 600                 605             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    610                 615                 620                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
625                 630                 635                 640 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                645                 650                 655     


Gln Ala Leu Pro Pro Arg 
            660         


<210>  185
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CIII (Construct 3)

<400>  185

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    450                 455                 460                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
465                 470                 475                 480 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                485                 490                 495     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            500                 505                 510         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        515                 520                 525             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    530                 535                 540                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
545                 550                 555                 560 


Gln Ala Leu Pro Pro Arg 
                565     


<210>  186
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CIV (Construct 4)

<400>  186

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys 
465                 470                 475                 480 


Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu 
                485                 490                 495     


Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe 
            500                 505                 510         


Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro 
        515                 520                 525             


Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn 
    530                 535                 540                 


Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr 
545                 550                 555                 560 


His Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                565                 570                 575     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            580                 585                 590         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        595                 600                 605             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    610                 615                 620                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
625                 630                 635                 640 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                645                 650                 655     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            660                 665                 670         


Ala Leu Pro Pro Arg 
        675         


<210>  187
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CV (Construct 5)

<400>  187

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Cys Arg Asn Thr Gly 
465                 470                 475                 480 


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
                485                 490                 495     


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
            500                 505                 510         


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
        515                 520                 525             


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
    530                 535                 540                 


Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
545                 550                 555                 560 


Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg 
                565                 570                 575     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            580                 585                 590         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        595                 600                 605             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    610                 615                 620                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
625                 630                 635                 640 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                645                 650                 655     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            660                 665                 670         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680         


<210>  188
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CVI (Construct 6)

<400>  188

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Gly Gly Asn Cys Arg Asn 
    450                 455                 460                 


Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro 
465                 470                 475                 480 


Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln 
                485                 490                 495     


Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly 
            500                 505                 510         


Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val 
        515                 520                 525             


Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
    530                 535                 540                 


Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val Lys Phe 
545                 550                 555                 560 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                565                 570                 575     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            580                 585                 590         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        595                 600                 605             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    610                 615                 620                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
625                 630                 635                 640 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                645                 650                 655     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665             


<210>  189
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CVII (Construct 7)

<400>  189

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Gly Gly Gly Gly Asn Cys 
    450                 455                 460                 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
465                 470                 475                 480 


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
                485                 490                 495     


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
            500                 505                 510         


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
        515                 520                 525             


Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
    530                 535                 540                 


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val 
545                 550                 555                 560 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                565                 570                 575     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            580                 585                 590         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        595                 600                 605             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    610                 615                 620                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
625                 630                 635                 640 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                645                 650                 655     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670 


<210>  190
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CVIII (Construct 8)

<400>  190

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Lys Glu Ser Gly Ser Val Ser Ser Glu Gln 
    450                 455                 460                 


Leu Ala Gln Phe Arg Ser Leu Asp Asn Cys Arg Asn Thr Gly Pro Trp 
465                 470                 475                 480 


Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe 
                485                 490                 495     


Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser 
            500                 505                 510         


Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu 
        515                 520                 525             


Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu 
    530                 535                 540                 


Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln 
545                 550                 555                 560 


Asp Pro Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  191
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CIX (Construct 9)

<400>  191

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu 
    450                 455                 460                 


Ser Lys Ser Thr Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
465                 470                 475                 480 


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
                485                 490                 495     


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
            500                 505                 510         


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
        515                 520                 525             


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr 
    530                 535                 540                 


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His 
545                 550                 555                 560 


Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                565                 570                 575     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            580                 585                 590         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        595                 600                 605             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
625                 630                 635                 640 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                645                 650                 655     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            660                 665                 670         


Leu Pro Pro Arg 
        675     


<210>  192
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QTX01-CX (Construct 10)

<400>  192

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Ser Asp Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Glu Lys Thr Val Ser Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr 
        115                 120                 125             


Trp Tyr Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Arg Lys Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ala Ser 
385                 390                 395                 400 


Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
                405                 410                 415     


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        435                 440                 445             


Val Ser Glu Ile Leu Glu Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly 
    450                 455                 460                 


Glu Phe Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys 
465                 470                 475                 480 


Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu 
                485                 490                 495     


His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser 
            500                 505                 510         


Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val 
        515                 520                 525             


Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala 
    530                 535                 540                 


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
545                 550                 555                 560 


Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                565                 570                 575     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            580                 585                 590         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        595                 600                 605             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    610                 615                 620                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
625                 630                 635                 640 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                645                 650                 655     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            660                 665                 670         


Pro Arg 
        


<210>  193
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RQR8

<400>  193

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala Cys Pro Tyr Ser Asn Pro Ser Leu Cys Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
        35                  40                  45              


Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Ala Cys Pro Tyr Ser 
    50                  55                  60                  


Asn Pro Ser Leu Cys Ser Gly Gly Gly Gly Ser Pro Ala Pro Arg Pro 
65                  70                  75                  80  


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                85                  90                  95      


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            100                 105                 110         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
    130                 135                 140                 


Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val 
145                 150                 155         


<210>  194
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge domain in Figure 15 constructs

<400>  194

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp 
    50                  55  


<210>  195
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 TM domain in Figure 15 constructs

<400>  195

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  196
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScFc used in Constructs 4-10 in Example 10

<400>  196

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Asp Gly Ser Asp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Gly Glu Ser Gly Pro Leu Asp Tyr Trp Tyr Leu Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Asp Val Val Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Gln Ser Ser Leu Asp Ile Ser His Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn 
            180                 185                 190         


Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


His Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  197

Ile Asp Gly Ser Gly 
1               5   


<210>  198
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIV (Construct 4) endodomain

<400>  198

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Asn Cys Arg Asn Thr Gly Pro Trp Leu 
        115                 120                 125             


Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser 
    130                 135                 140                 


Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser 
145                 150                 155                 160 


Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile 
                165                 170                 175     


Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro 
            180                 185                 190         


Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp 
        195                 200                 205             


Pro Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp 
    210                 215                 220                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
225                 230                 235                 240 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                245                 250                 255     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            260                 265                 270         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        275                 280                 285             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    290                 295                 300                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
305                 310                 315                 320 


Met Gln Ala Leu Pro Pro Arg 
                325         


<210>  199
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CV (Construct 5) endodomain

<400>  199

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Cys Arg Asn 
        115                 120                 125             


Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro 
    130                 135                 140                 


Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln 
145                 150                 155                 160 


Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly 
                165                 170                 175     


Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val 
            180                 185                 190         


Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
        195                 200                 205             


Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val Lys Phe 
    210                 215                 220                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
225                 230                 235                 240 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                245                 250                 255     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            260                 265                 270         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        275                 280                 285             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    290                 295                 300                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
305                 310                 315                 320 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330         


<210>  200
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVI (Construct 6) endodomain

<400>  200

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Gly Gly Asn Cys 
            100                 105                 110         


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
        115                 120                 125             


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
    130                 135                 140                 


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
145                 150                 155                 160 


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
                165                 170                 175     


Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            180                 185                 190         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val 
        195                 200                 205             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    210                 215                 220                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
225                 230                 235                 240 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                245                 250                 255     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            260                 265                 270         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        275                 280                 285             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    290                 295                 300                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315             


<210>  201
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVII (Construct 7) endodomain

<400>  201

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
        115                 120                 125             


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
    130                 135                 140                 


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
145                 150                 155                 160 


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
                165                 170                 175     


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            180                 185                 190         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Cys Thr 
        195                 200                 205             


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
    210                 215                 220                 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
225                 230                 235                 240 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
                245                 250                 255     


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  202
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CVIII (Construct 8) endodomain

<400>  202

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Lys Glu Ser Gly Ser Val Ser Ser 
            100                 105                 110         


Glu Gln Leu Ala Gln Phe Arg Ser Leu Asp Asn Cys Arg Asn Thr Gly 
        115                 120                 125             


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
    130                 135                 140                 


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
145                 150                 155                 160 


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
                165                 170                 175     


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
            180                 185                 190         


Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
        195                 200                 205             


Gly Gln Asp Pro Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg 
    210                 215                 220                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
225                 230                 235                 240 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                245                 250                 255     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            260                 265                 270         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        275                 280                 285             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    290                 295                 300                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
305                 310                 315                 320 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330 


<210>  203
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CIX (Construct 9) endodomain

<400>  203

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Glu Gly Lys Ser Ser Gly Ser Gly 
            100                 105                 110         


Ser Glu Ser Lys Ser Thr Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys 
        115                 120                 125             


Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln 
    130                 135                 140                 


Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser 
                165                 170                 175     


Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu 
            180                 185                 190         


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
        195                 200                 205             


Thr His Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    210                 215                 220                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
225                 230                 235                 240 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                245                 250                 255     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            260                 265                 270         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        275                 280                 285             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    290                 295                 300                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
305                 310                 315                 320 


Gln Ala Leu 
            


<210>  204
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CX (Construct 10) endodomain

<400>  204

Asn His Arg Pro Pro Ala Trp Val Arg Ser Lys Arg Ser Arg Leu Leu 
1               5                   10                  15      


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            20                  25                  30          


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        35                  40                  45              


Ala Ser Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu 
    50                  55                  60                  


Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val 
65                  70                  75                  80  


Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu 
                85                  90                  95      


Cys Leu Val Ser Glu Ile Leu Glu Gly Ser Ala Gly Ser Ala Ala Gly 
            100                 105                 110         


Ser Gly Glu Phe Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
        115                 120                 125             


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
    130                 135                 140                 


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
145                 150                 155                 160 


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
                165                 170                 175     


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr 
            180                 185                 190         


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His 
        195                 200                 205             


Leu Val Cys Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    210                 215                 220                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
225                 230                 235                 240 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                245                 250                 255     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            260                 265                 270         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        275                 280                 285             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    290                 295                 300                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
305                 310                 315                 320 


Leu Pro Pro Arg 
                


<210>  205
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 and CD28 intracellular domain parts in Figure 15 constructs

<400>  205

Asn His Arg Pro Pro Ala Trp Val 
1               5               


