                         SEQUENCE LISTING

<110>  ԰Ƽ޹˾
 
<120>  ACE2ںϵףӦ

<130>  RYP2010572.6

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala Asp 
        595     


<210>  2
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  2

Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala Asp 
        595     


<210>  3
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  3

Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        595                 600                 605             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    610                 615                 620                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
625                 630                 635                 640 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                645                 650                 655     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            660                 665                 670         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        675                 680                 685             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    690                 695                 700                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
705                 710                 715                 720 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                725                 730                 735     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            740                 745                 750         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        755                 760                 765             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    770                 775                 780                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
785                 790                 795                 800 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                805                 810                 815     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825             


<210>  4
<211>  828
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4

Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
            20                  25                  30          


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
        35                  40                  45              


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
    50                  55                  60                  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
                85                  90                  95      


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
            100                 105                 110         


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
        115                 120                 125             


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
    130                 135                 140                 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
145                 150                 155                 160 


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
                165                 170                 175     


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
            180                 185                 190         


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
        195                 200                 205             


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
    210                 215                 220                 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
225                 230                 235                 240 


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
                245                 250                 255     


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
            260                 265                 270         


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
        275                 280                 285             


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
    290                 295                 300                 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
305                 310                 315                 320 


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
                325                 330                 335     


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
            340                 345                 350         


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
        355                 360                 365             


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
    370                 375                 380                 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
385                 390                 395                 400 


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
                405                 410                 415     


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
            420                 425                 430         


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
        435                 440                 445             


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
    450                 455                 460                 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
465                 470                 475                 480 


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
                485                 490                 495     


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
            500                 505                 510         


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
        515                 520                 525             


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
    530                 535                 540                 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
545                 550                 555                 560 


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
                565                 570                 575     


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
            580                 585                 590         


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        595                 600                 605             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    610                 615                 620                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
625                 630                 635                 640 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                645                 650                 655     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            660                 665                 670         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        675                 680                 685             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    690                 695                 700                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
705                 710                 715                 720 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                725                 730                 735     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            740                 745                 750         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        755                 760                 765             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    770                 775                 780                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
785                 790                 795                 800 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                805                 810                 815     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            820                 825             


<210>  5
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  5

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 


<210>  6
<211>  844
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  6

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        835                 840                 


<210>  7
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  7

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Thr Gly Lys Pro Thr Leu Tyr 
        835                 840                 845             


Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
    850                 855                 860         


<210>  8
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  8

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Thr Gly Lys Pro Thr Leu Tyr 
        835                 840                 845             


Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
    850                 855                 860         


<210>  9
<211>  1273
<212>  PRT
<213>  Coaxana purpurea

<400>  9

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  10
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  10

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  11
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  11

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  12
<211>  1208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  12

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln 
    1205             


<210>  13
<211>  1443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  13

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Ala Ala Thr 
        835                 840                 845             


Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
    850                 855                 860                 


Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr 
865                 870                 875                 880 


Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp Lys 
                885                 890                 895     


Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr Pro 
            900                 905                 910         


Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala Leu 
        915                 920                 925             


Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg Leu 
    930                 935                 940                 


Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys Val 
945                 950                 955                 960 


Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu 
                965                 970                 975     


Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp Ala 
            980                 985                 990         


Trp Glu Ser Trp Arg Ser Glu Val  Gly Lys Gln Leu Arg  Pro Leu Tyr 
        995                 1000                 1005             


Glu Glu  Tyr Val Val Leu Lys  Asn Glu Met Ala Arg  Ala Asn His 
    1010                 1015                 1020             


Tyr Glu  Asp Tyr Gly Asp Tyr  Trp Arg Gly Asp Tyr  Glu Val Asn 
    1025                 1030                 1035             


Gly Val  Asp Gly Tyr Asp Tyr  Ser Arg Gly Gln Leu  Ile Glu Asp 
    1040                 1045                 1050             


Val Glu  His Thr Phe Glu Glu  Ile Lys Pro Leu Tyr  Glu His Leu 
    1055                 1060                 1065             


His Ala  Tyr Val Arg Ala Lys  Leu Met Asn Ala Tyr  Pro Ser Tyr 
    1070                 1075                 1080             


Ile Ser  Pro Ile Gly Cys Leu  Pro Ala His Leu Leu  Gly Asp Met 
    1085                 1090                 1095             


Trp Gly  Arg Phe Trp Thr Asn  Leu Tyr Ser Leu Thr  Val Pro Phe 
    1100                 1105                 1110             


Gly Gln  Lys Pro Asn Ile Asp  Val Thr Asp Ala Met  Val Asp Gln 
    1115                 1120                 1125             


Ala Trp  Asp Ala Gln Arg Ile  Phe Lys Glu Ala Glu  Lys Phe Phe 
    1130                 1135                 1140             


Val Ser  Val Gly Leu Pro Asn  Met Thr Gln Gly Phe  Trp Glu Asn 
    1145                 1150                 1155             


Ser Met  Leu Thr Asp Pro Gly  Asn Val Gln Lys Ala  Val Cys His 
    1160                 1165                 1170             


Pro Thr  Ala Trp Asp Leu Gly  Lys Gly Asp Phe Arg  Ile Leu Met 
    1175                 1180                 1185             


Cys Thr  Lys Val Thr Met Asp  Asp Phe Leu Thr Ala  His Asn Glu 
    1190                 1195                 1200             


Met Gly  Asn Ile Gln Tyr Asp  Met Ala Tyr Ala Ala  Gln Pro Phe 
    1205                 1210                 1215             


Leu Leu  Arg Asn Gly Ala Asn  Glu Gly Phe His Glu  Ala Val Gly 
    1220                 1225                 1230             


Glu Ile  Met Ser Leu Ser Ala  Ala Thr Pro Lys His  Leu Lys Ser 
    1235                 1240                 1245             


Ile Gly  Leu Leu Ser Pro Asp  Phe Gln Glu Asp Asn  Glu Thr Glu 
    1250                 1255                 1260             


Ile Asn  Phe Leu Leu Lys Gln  Ala Leu Thr Ile Val  Gly Thr Leu 
    1265                 1270                 1275             


Pro Phe  Thr Tyr Met Leu Glu  Lys Trp Arg Trp Met  Val Phe Lys 
    1280                 1285                 1290             


Gly Glu  Ile Pro Lys Asp Gln  Trp Met Lys Lys Trp  Trp Glu Met 
    1295                 1300                 1305             


Lys Arg  Glu Ile Val Gly Val  Val Glu Pro Val Pro  His Asp Glu 
    1310                 1315                 1320             


Thr Tyr  Cys Asp Pro Ala Ser  Leu Phe His Val Ser  Asn Asp Tyr 
    1325                 1330                 1335             


Ser Phe  Ile Arg Tyr Tyr Thr  Arg Thr Leu Tyr Gln  Phe Gln Phe 
    1340                 1345                 1350             


Gln Glu  Ala Leu Cys Gln Ala  Ala Lys His Glu Gly  Pro Leu His 
    1355                 1360                 1365             


Lys Cys  Asp Ile Ser Asn Ser  Thr Glu Ala Gly Gln  Lys Leu Phe 
    1370                 1375                 1380             


Asn Met  Leu Arg Leu Gly Lys  Ser Glu Pro Trp Thr  Leu Ala Leu 
    1385                 1390                 1395             


Glu Asn  Val Val Gly Ala Lys  Asn Met Asn Val Arg  Pro Leu Leu 
    1400                 1405                 1410             


Asn Tyr  Phe Glu Pro Leu Phe  Thr Trp Leu Lys Asp  Gln Asn Lys 
    1415                 1420                 1425             


Asn Ser  Phe Val Gly Trp Ser  Thr Asp Trp Ser Pro  Tyr Ala Asp 
    1430                 1435                 1440             


<210>  14
<211>  1440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  14

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys 
    610                 615                 620                 


Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser 
625                 630                 635                 640 


Trp Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn 
                645                 650                 655     


Asn Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu 
            660                 665                 670         


Ala Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu 
        675                 680                 685             


Gln Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp 
    690                 695                 700                 


Lys Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr 
705                 710                 715                 720 


Ser Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu 
                725                 730                 735     


Leu Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn 
            740                 745                 750         


Glu Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln 
        755                 760                 765             


Leu Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala 
    770                 775                 780                 


Arg Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr 
785                 790                 795                 800 


Glu Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile 
                805                 810                 815     


Glu Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His 
            820                 825                 830         


Leu His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr 
        835                 840                 845             


Ile Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp 
    850                 855                 860                 


Gly Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln 
865                 870                 875                 880 


Lys Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp 
                885                 890                 895     


Ala Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly 
            900                 905                 910         


Leu Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp 
        915                 920                 925             


Pro Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu 
    930                 935                 940                 


Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp 
945                 950                 955                 960 


Asp Phe Leu Thr Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met 
                965                 970                 975     


Ala Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly 
            980                 985                 990         


Phe His Glu Ala Val Gly Glu Ile  Met Ser Leu Ser Ala  Ala Thr Pro 
        995                 1000                 1005             


Lys His  Leu Lys Ser Ile Gly  Leu Leu Ser Pro Asp  Phe Gln Glu 
    1010                 1015                 1020             


Asp Asn  Glu Thr Glu Ile Asn  Phe Leu Leu Lys Gln  Ala Leu Thr 
    1025                 1030                 1035             


Ile Val  Gly Thr Leu Pro Phe  Thr Tyr Met Leu Glu  Lys Trp Arg 
    1040                 1045                 1050             


Trp Met  Val Phe Lys Gly Glu  Ile Pro Lys Asp Gln  Trp Met Lys 
    1055                 1060                 1065             


Lys Trp  Trp Glu Met Lys Arg  Glu Ile Val Gly Val  Val Glu Pro 
    1070                 1075                 1080             


Val Pro  His Asp Glu Thr Tyr  Cys Asp Pro Ala Ser  Leu Phe His 
    1085                 1090                 1095             


Val Ser  Asn Asp Tyr Ser Phe  Ile Arg Tyr Tyr Thr  Arg Thr Leu 
    1100                 1105                 1110             


Tyr Gln  Phe Gln Phe Gln Glu  Ala Leu Cys Gln Ala  Ala Lys His 
    1115                 1120                 1125             


Glu Gly  Pro Leu His Lys Cys  Asp Ile Ser Asn Ser  Thr Glu Ala 
    1130                 1135                 1140             


Gly Gln  Lys Leu Phe Asn Met  Leu Arg Leu Gly Lys  Ser Glu Pro 
    1145                 1150                 1155             


Trp Thr  Leu Ala Leu Glu Asn  Val Val Gly Ala Lys  Asn Met Asn 
    1160                 1165                 1170             


Val Arg  Pro Leu Leu Asn Tyr  Phe Glu Pro Leu Phe  Thr Trp Leu 
    1175                 1180                 1185             


Lys Asp  Gln Asn Lys Asn Ser  Phe Val Gly Trp Ser  Thr Asp Trp 
    1190                 1195                 1200             


Ser Pro  Tyr Ala Asp Glu Pro  Lys Ser Ser Asp Lys  Thr His Thr 
    1205                 1210                 1215             


Cys Pro  Pro Cys Pro Ala Pro  Glu Leu Leu Gly Gly  Pro Ser Val 
    1220                 1225                 1230             


Phe Leu  Phe Pro Pro Lys Pro  Lys Asp Thr Leu Met  Ile Ser Arg 
    1235                 1240                 1245             


Thr Pro  Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
    1250                 1255                 1260             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1265                 1270                 1275             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1280                 1285                 1290             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1295                 1300                 1305             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1310                 1315                 1320             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1325                 1330                 1335             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1340                 1345                 1350             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1355                 1360                 1365             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1370                 1375                 1380             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1385                 1390                 1395             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1400                 1405                 1410             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1415                 1420                 1425             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1430                 1435                 1440 


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  15

Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  16

Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr 
1               5                   10                  15      


Cys Tyr 
        


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  17

Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
1               5                   10                  15      


Ala Gly Thr Cys Tyr 
            20      


<210>  18
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  18

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
            20                  25                  30          


Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn 
        35                  40                  45              


Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala Gly Asp 
    50                  55                  60                  


Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln Met Tyr 
65                  70                  75                  80  


Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu Gln Ala 
                85                  90                  95      


Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser Lys Arg 
            100                 105                 110         


Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr Gly Lys 
        115                 120                 125             


Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly 
    130                 135                 140                 


Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg Leu Trp 
145                 150                 155                 160 


Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg Pro Leu 
                165                 170                 175     


Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala Asn His 
            180                 185                 190         


Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val Asn Gly 
        195                 200                 205             


Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp Val Glu 
    210                 215                 220                 


His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His Ala Tyr 
225                 230                 235                 240 


Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser Pro Ile 
                245                 250                 255     


Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp 
            260                 265                 270         


Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile 
        275                 280                 285             


Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln Arg Ile 
    290                 295                 300                 


Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met 
305                 310                 315                 320 


Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val 
                325                 330                 335     


Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp 
            340                 345                 350         


Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr 
        355                 360                 365             


Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr Ala Ala 
    370                 375                 380                 


Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala 
385                 390                 395                 400 


Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His Leu Lys 
                405                 410                 415     


Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu Thr Glu 
            420                 425                 430         


Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro 
        435                 440                 445             


Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu 
    450                 455                 460                 


Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys Arg Glu 
465                 470                 475                 480 


Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp 
                485                 490                 495     


Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile Arg Tyr 
            500                 505                 510         


Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Gln 
        515                 520                 525             


Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser 
    530                 535                 540                 


Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly Lys Ser 
545                 550                 555                 560 


Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys Asn Met 
                565                 570                 575     


Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr Trp Leu 
            580                 585                 590         


Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp Trp Ser 
        595                 600                 605             


Pro Tyr Ala Asp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
    610                 615                 620                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
625                 630                 635                 640 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                645                 650                 655     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            660                 665                 670         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        675                 680                 685             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    690                 695                 700                 


Val Cys His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
705                 710                 715                 720 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                725                 730                 735     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            740                 745                 750         


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        755                 760                 765             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    770                 775                 780                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
785                 790                 795                 800 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                805                 810                 815     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            820                 825                 830         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Thr Gly Lys Pro Thr Leu Tyr 
        835                 840                 845             


Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
    850                 855                 860         


