                         SEQUENCE LISTING

<110>  SYMVIVO CORPORATION
 
<120>  GENE DELIVERY SYSTEM

<130>  V814967WO

<150>  US 62/981,464
<151>  2020-02-25

<150>  US 63/079,841
<151>  2020-09-17

<160>  56    

<170>  PatentIn version 3.5

<210>  1

<400>  1
000

<210>  2
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transporter polypeptide HTP

<400>  2

Met Thr Leu Thr Gly Thr Leu Arg Lys Ala Phe Ala Thr Thr Leu Ala 
1               5                   10                  15      


Ala Ala Met Leu Ile Gly Thr Leu Ala Gly Cys Ser Ser Ala Ala Tyr 
            20                  25                  30          


Asn Lys Ser Asp Leu Val Ser Lys Ile Ala Gln Lys Ser Asn Leu Thr 
        35                  40                  45              


Lys Ala Gln Ala Glu Ala Ala Val Asn Ala Phe Gln Asp Val Phe Val 
    50                  55                  60                  


Glu Ala Met Lys Ser Gly Glu Gly Leu Lys Leu Thr Gly Leu Phe Ser 
65                  70                  75                  80  


Ala Glu Arg Val Lys Arg Pro Ala Arg Thr Gly Arg Asn Pro Arg Thr 
                85                  90                  95      


Gly Glu Gln Ile Asp Ile Pro Ala Ser Tyr Gly Val Arg Ile Ser Ala 
            100                 105                 110         


Gly Ser Leu Leu Lys Lys Ala Val Thr Glu Tyr Gly Arg Lys Lys Arg 
        115                 120                 125             


Arg Gln Arg Arg Arg 
    130             


<210>  3
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-IL-12

<400>  3

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
    530                 535                 540                 


Gly Ser Ile Ile Ile Gly Pro Leu Ile Phe Val Phe Leu Phe Ser Val 
545                 550                 555                 560 


Val Ile Gly Ser Ile Tyr Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly 
                565                 570                 575     


Pro 
    


<210>  4
<211>  429
<212>  DNA
<213>  Bifidobacterium longum

<400>  4
gaaaacaatt tggagaacct gaccattggc gttttcgcca ggacggccgg ggtcaatgtg       60

gagaccatcc ggttctatca gcgcaagggc ttgctcccgg aaccggacaa gccttacggc      120

agcattcgcc gctatggcga gacggatgta acgcgggtgc gcttcgtgaa atcagcccag      180

cggttgggct tcagcctgga tgagatcgcc gagctgctgc ggctggagga tggcacccat      240

tgcgaggaag ccagcagcct ggccgagcac aagctcaagg acgtgcgcga gaggatggct      300

gacctggcgc gcatggaggc cgtgctgtct gatttggtgt gcgcctgcca tgcgcgaagg      360

gggaacgttt cctgcccgct gatcgcgtca ctacagggtg gagcaagctt ggcaggttcg      420

gctatgcct                                                              429


<210>  5
<211>  143
<212>  PRT
<213>  Bifidobacterium longum

<400>  5

Glu Asn Asn Leu Glu Asn Leu Thr Ile Gly Val Phe Ala Arg Thr Ala 
1               5                   10                  15      


Gly Val Asn Val Glu Thr Ile Arg Phe Tyr Gln Arg Lys Gly Leu Leu 
            20                  25                  30          


Pro Glu Pro Asp Lys Pro Tyr Gly Ser Ile Arg Arg Tyr Gly Glu Thr 
        35                  40                  45              


Asp Val Thr Arg Val Arg Phe Val Lys Ser Ala Gln Arg Leu Gly Phe 
    50                  55                  60                  


Ser Leu Asp Glu Ile Ala Glu Leu Leu Arg Leu Glu Asp Gly Thr His 
65                  70                  75                  80  


Cys Glu Glu Ala Ser Ser Leu Ala Glu His Lys Leu Lys Asp Val Arg 
                85                  90                  95      


Glu Arg Met Ala Asp Leu Ala Arg Met Glu Ala Val Leu Ser Asp Leu 
            100                 105                 110         


Val Cys Ala Cys His Ala Arg Arg Gly Asn Val Ser Cys Pro Leu Ile 
        115                 120                 125             


Ala Ser Leu Gln Gly Gly Ala Ser Leu Ala Gly Ser Ala Met Pro 
    130                 135                 140             


<210>  6
<211>  276
<212>  DNA
<213>  Bifidobacterium longum

<400>  6
gcatacaaca agtctgacct cgtttcgaag atcgcccaga agtccaacct gaccaaggct       60

caggccgagg ctgctgttaa cgccttccag gatgtgttcg tcgaggctat gaagtccggc      120

gaaggcctga agctcaccgg cctgttctcc gctgagcgcg tcaagcgccc ggctcgcacc      180

ggccgcaacc cgcgcactgg cgagcagatt gacattccgg cttcctacgg cgttcgtatc      240

tccgctggct ccctgctgaa gaaggccgtc accgag                                276


<210>  7
<211>  92
<212>  PRT
<213>  Bifidobacterium longum

<400>  7

Ala Tyr Asn Lys Ser Asp Leu Val Ser Lys Ile Ala Gln Lys Ser Asn 
1               5                   10                  15      


Leu Thr Lys Ala Gln Ala Glu Ala Ala Val Asn Ala Phe Gln Asp Val 
            20                  25                  30          


Phe Val Glu Ala Met Lys Ser Gly Glu Gly Leu Lys Leu Thr Gly Leu 
        35                  40                  45              


Phe Ser Ala Glu Arg Val Lys Arg Pro Ala Arg Thr Gly Arg Asn Pro 
    50                  55                  60                  


Arg Thr Gly Glu Gln Ile Asp Ile Pro Ala Ser Tyr Gly Val Arg Ile 
65                  70                  75                  80  


Ser Ala Gly Ser Leu Leu Lys Lys Ala Val Thr Glu 
                85                  90          


<210>  8
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zinc finger DNA binding domain

<400>  8
gaaaaactgc gcaacggcag cggcgatccg ggcaaaaaaa aacagcatgc gtgcccggaa       60

tgcggcaaaa gctttagcca gagcagcgat ctgcagcgcc atcagcgcac ccataccggc      120

gaaaaaccgt ataaatgccc ggaatgcggc aaaagcttta gccgcagcga tgaactgcag      180

cgccatcagc gcacccatac cggcgaaaaa ccgtataaat gcccggaatg cggcaaaagc      240

tttagccgca gcgatcatct gagccgccat cagcgcaccc atcagaacaa aaaa            294


<210>  9
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zinc finger DNA binding domain

<400>  9

Glu Lys Leu Arg Asn Gly Ser Gly Asp Pro Gly Lys Lys Lys Gln His 
1               5                   10                  15      


Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Ser Ser Asp Leu Gln 
            20                  25                  30          


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
        35                  40                  45              


Cys Gly Lys Ser Phe Ser Arg Ser Asp Glu Leu Gln Arg His Gln Arg 
    50                  55                  60                  


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
65                  70                  75                  80  


Phe Ser Arg Ser Asp His Leu Ser Arg His Gln Arg Thr His Gln Asn 
                85                  90                  95      


Lys Lys 
        


<210>  10
<211>  84
<212>  DNA
<213>  Bifidobacterium longum

<400>  10
aagcttgtcg acctgcagcc ttggcgcttg actccgtaca tgagtacgga agtaaggtta       60

cgctatcctt ggctgcagaa gctt                                              84


<210>  11
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zinc finger DNA binding domain recognition site

<400>  11
aagctttttt ttttttgggg cggctttttt tttttaagct t                           41


<210>  12
<211>  90
<212>  DNA
<213>  Bifidobacterium longum

<400>  12
atgaccctga ccggcaccct gcgcaaggcc ttcgccacca ccctggccgc cgccatgctg       60

atcggcaccc tggccggctg ctcctccgcc                                        90


<210>  13
<211>  30
<212>  PRT
<213>  Bifidobacterium longum

<400>  13

Met Thr Leu Thr Gly Thr Leu Arg Lys Ala Phe Ala Thr Thr Leu Ala 
1               5                   10                  15      


Ala Ala Met Leu Ile Gly Thr Leu Ala Gly Cys Ser Ser Ala 
            20                  25                  30  


<210>  14
<211>  111
<212>  DNA
<213>  Bifidobacterium longum

<400>  14
atgaaacatc ggaaacccgc accggcctgg cataggctgg ggctgaagat tagcaagaaa       60

gtggtggtcg gcatcaccgc cgcggcgacc gccttcggcg gactggcaat c               111


<210>  15
<211>  37
<212>  PRT
<213>  Bifidobacterium longum

<400>  15

Met Lys His Arg Lys Pro Ala Pro Ala Trp His Arg Leu Gly Leu Lys 
1               5                   10                  15      


Ile Ser Lys Lys Val Val Val Gly Ile Thr Ala Ala Ala Thr Ala Phe 
            20                  25                  30          


Gly Gly Leu Ala Ile 
        35          


<210>  16
<211>  138
<212>  DNA
<213>  Bifidobacterium longum

<400>  16
atgaaacatc ggaaacccgc accggcctgg cataggctgg ggctgaagat tagcaagaaa       60

gtggtggtcg gcatcaccgc cgcggcgacc gccttcggcg gactggcaat cgccagcacc      120

gcagcacagg ccagcacc                                                    138


<210>  17
<211>  46
<212>  PRT
<213>  Bifidobacterium longum

<400>  17

Met Lys His Arg Lys Pro Ala Pro Ala Trp His Arg Leu Gly Leu Lys 
1               5                   10                  15      


Ile Ser Lys Lys Val Val Val Gly Ile Thr Ala Ala Ala Thr Ala Phe 
            20                  25                  30          


Gly Gly Leu Ala Ile Ala Ser Thr Ala Ala Gln Ala Ser Thr 
        35                  40                  45      


<210>  18
<211>  11
<212>  PRT
<213>  Human Immunodeficiency virus

<400>  18

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  19
<211>  16
<212>  PRT
<213>  Antennapedia Drosophilamelanogaster

<400>  19

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Human immunodeficiency virus

<400>  20

Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
1               5                   10                  15      


Phe 
    


<210>  21
<211>  17
<212>  PRT
<213>  Human immunodeficiency virus

<400>  21

Asn Ala Lys Thr Arg Arg His Glu Arg Arg Arg Lys Leu Ala Ile Glu 
1               5                   10                  15      


Arg 
    


<210>  22
<211>  27
<212>  PRT
<213>  Simian Virus 40

<400>  22

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transportan (Galanin-mastoparan) CPP

<400>  23

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  24
<211>  21
<212>  PRT
<213>  Simian Virus


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X may be Arginine or Lysine

<400>  24

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Xaa Val 
            20      


<210>  25
<211>  10
<212>  PRT
<213>  Human immunodeficiency virus 1

<400>  25

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HRSV CPP

<400>  26

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AIP6 CPP

<400>  27

Arg Leu Arg Trp Arg 
1               5   


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARF(1-22) CPP

<400>  28

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pVEC CPP

<400>  29

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAP17 CPP

<400>  30

Gln Leu Ala Leu Gln Leu Ala Leu Gln Ala Leu Gln Ala Ala Leu Gln 
1               5                   10                  15      


Leu Ala 
        


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VT5 CPP

<400>  31

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bac7 CPP

<400>  32

Arg Arg Ile Arg Pro Arg Pro Pro Arg Leu Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Leu Pro Phe Pro Arg Pro Gly 
            20                  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (PPR)n CPP

<400>  33

Pro Pro Arg Pro Pro Arg Pro Pro Arg 
1               5                   


<210>  34
<211>  20
<212>  PRT
<213>  Herpes Simplex virus 1

<400>  34

His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
1               5                   10                  15      


Ile Arg Ala Phe 
            20  


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GALA CPP

<400>  35

Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210>  36
<211>  24
<212>  PRT
<213>  Influenza

<400>  36

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys 
            20                  


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C105Y CPP

<400>  37

Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu 
1               5                   10                  15      


Ile 
    


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PFVYLI CPP

<400>  38

Pro Phe Val Tyr Leu Ile 
1               5       


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep-7 CPP

<400>  39

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CADY CPP

<400>  40

Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Arg Ala 
            20  


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAP CPP

<400>  41

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R6W3 CPP

<400>  42

Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   


<210>  43
<211>  5714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFRG3.5-CMV-GLuc

<400>  43
atgtgagcaa aaggccagca aaaggccagg gaccgtaaaa aggccgcgtt gctggcgttt       60

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      120

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      180

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      240

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      300

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      360

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      420

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      480

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      540

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      600

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      660

atcttttcta cgggtttttt tggggcggct ttgaattctt ttttttgggg cggctttttt      720

tttatgcgct cacgcaactg gtccagaacc ttgaccgaac gcagcggtgg taacggcgca      780

gtggcggttt tcatggcttg ttatgactgt ttttttgggg tacagtctat gcctcgggca      840

tccaagcagc aagcgcgtta cgccgtgggt cgatgtttga tgttatggag cagcaacgat      900

gttacgcagc agggcagtcg ccctaaaaca aagttaaaca tcatgaggga agcggtgatc      960

gccgaagtat cgactcaact atcagaggta gttggcgtca tcgagcgcca tctcgaaccg     1020

acgttgctgg ccgtacattt gtacggctcc gcagtggatg gcggcctgaa gccacacagt     1080

gatattgatt tgctggttac ggtgaccgta aggcttgatg aaacaacgcg gcgagctttg     1140

atcaacgacc ttttggaaac ttcggcttcc cctggagaga gcgagattct ccgcgctgta     1200

gaagtcacca ttgttgtgca cgacgacatc attccgtggc gttatccagc taagcgcgaa     1260

ctgcaatttg gagaatggca gcgcaatgac attcttgcag gtatcttcga gccagccacg     1320

atcgacattg atctggctat cttgctgaca aaagcaagag aacatagcgt tgccttggta     1380

ggtccagcgg cggaggaact ctttgatccg gttcctgaac aggatctatt tgaggcgcta     1440

aatgaaacct taacgctatg gaactcgccg cccgactggg ctggcgatga gcgaaatgta     1500

gtgcttacgt tgtcccgcat ttggtacagc gcagtaaccg gcaaaatcgc gccgaaggat     1560

gtcgctgccg actgggcaat ggagcgcctg ccggcccagt atcagcccgt catacttgaa     1620

gctagacagg cttatcttgg acaagaagaa gatcgcttgg cctcgcgcgc agatcagttg     1680

gaagaatttg tccactacgt gaaaggcgag atcaccaagg tagtcggcaa ataaggtacc     1740

gttaggcgtt ttcgcgatgt acgggccaga tatacgcgtt gacattgatt attgactagt     1800

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1860

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1920

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1980

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     2040

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     2100

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     2160

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     2220

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     2280

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     2340

tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     2400

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg gactctagag     2460

gatcgaagct agccaccatg ggagtcaaag ttctgtttgc cctgatctgc atcgctgtgg     2520

ccgaggccaa gcccaccgag aacaacgaag acttcaacat cgtggccgtg gccagcaact     2580

tcgcgaccac ggatctcgat gctgaccgcg ggaagttgcc cggcaagaag ctgccgctgg     2640

aggtgctcaa agagatggaa gccaatgccc ggaaagctgg ctgcaccagg ggctgtctga     2700

tctgcctgtc ccacatcaag tgcacgccca agatgaagaa gttcatccca ggacgctgcc     2760

acacctacga aggcgacaaa gagtccgcac agggcggcat aggcgaggcg atcgtcgaca     2820

ttcctgagat tcctgggttc aaggacttgg agcccatgga gcagttcatc gcacaggtcg     2880

atctgtgtgt ggactgcaca actggctgcc tcaaagggct tgccaacgtg cagtgttctg     2940

acctgctcaa gaagtggctg ccgcaacgct gtgcgacctt tgccagcaag atccagggcc     3000

aggtggacaa gatcaagggg gccggtggtg actaatcgat ccctaccggt tagtaatgag     3060

tttaaacggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg aacccgcgct     3120

atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg ttcataaacg     3180

cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagacccc attggggcca     3240

atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg aaggcccagg     3300

gctcgcagcc aacgtcgggg cggcaggccc tgccatagct ttttggggcg gcttttctcg     3360

agtccttcct taaggacgtg ctcgtcaatt tttgttttga gagtcatcta ttcggatgct     3420

tttcatgaag ttttttatga ccctgaccgg caccctgcgc aaggccttcg ccaccaccct     3480

ggccgccgcc atgctgatcg gcaccctggc cggctgctcc tccgccgcat acaacaagtc     3540

tgacctcgtt tcgaagatcg cccagaagtc caacctgacc aaggctcagg ccgaggctgc     3600

tgttaacgcc ttccaggatg tgttcgtcga ggctatgaag tccggcgaag gcctgaagct     3660

caccggcctg ttctccgctg agcgcgtcaa gcgcccggct cgcaccggcc gcaacccgcg     3720

cactggcgag cagattgaca ttccggcttc ctacggcgtt cgtatctccg ctggctccct     3780

gctgaagaag gccgtcaccg agtatggacg gaagaagcgc aggcagcgac ggcgatgagg     3840

gtttgcgctt gcgtcgtgga gggagcggaa cgccgaaaaa ggatccacgc gctggagatg     3900

ttcaacgagt agatcgccac ggcgacctcc ttccacgcgt gcgggcacgg ggattctcaa     3960

ggggccggcc cgaggcccct tgagcccgcc gggaggcgcc cccggcaggg cgggaatcca     4020

aagggcggag ccctgtggcc ctccccgggc aggggcggga tcgtcaaggg cggagccctt     4080

ggccccctcg ggagagcgca ctgacacaat gctacctccg gtagcattaa gtgcgccctc     4140

cgccatgcgg agggacgggc cgcgaccgga tatgcgggga acgtccacga cgcgtcttcc     4200

gtgtcctccg tcctgccttg tgccgtcgat tataatcctc ggataacgga cgatgattga     4260

accgattgga ggaaacgaga tgccgaagag tttcgcgcag cagatcgagg acgacgagaa     4320

caagatcaag cgcatccggg agcaccagcg catggtcagg gccaaacaag ccaaacagga     4380

gcgcaacgcc cgcaccaaaa ggctcgtgga gaccggagcg atagtggaaa aagcgcacgg     4440

cggcgcgtac gacgacgaag gacggcagac gttctcggat ggtctgaacg gcatcatctc     4500

ggtctacgac ccgtcccgcg gcggcaacgt ggacatgaga gtcatcgacg taatcgaccg     4560

gcgcatcccc agattgccaa ggtccgaaac cacaacaggc acggcagcgg cggcatcgcg     4620

aaccgtgcaa gccaccgcac cacagccagc ccacgcccaa ccgcaaagct tcacgcccaa     4680

cccccagcgc atcgaacacc ggacaggagc acagcagccg gatcggtggg cctagccggg     4740

acggcgcagc cctcgctccg ctgggctgaa atatctgact tggttcgtaa catatttccg     4800

acatgtcgga aatatgtcgt atcatcgttg ctatgagtac tgaacttcgt gagcagtggg     4860

agcagcttta cctgccgctg cgcccgctgt gcacgaacga cttcatcgag ggcgtgtacc     4920

ggcagcccag ggcgaaggcg ctggagggct accggtacat cgaggcgaac cccaagaccg     4980

tcagcgacct gctcgtggtc gacatcgacg acgcgaacgc ccgcgcgatg gccctatggg     5040

agcatgaggg gatgctgccc aacgtgatcg tggagaaccc gagaaacggc cacgcgcacg     5100

ccgtgtgggc gctggccgcc ccgttcagtc gcaccgaata cgcgcggcgc aagccgctcg     5160

ccctggccgc ggcggtcacg gaggggctgc gccgctcgtg cgacggggac aagggatatt     5220

cggggctgat gaccaagaac ccgctgcacg aggcgtggaa cagcgaactg gtcaccgatc     5280

acctgtacgg gctggacgaa ctgcgcgagg cgctggagga gtccggggac atgccgccgg     5340

cctcgtggaa gcgcacgaaa cggcgcaacg tggtcggatt gggccgcaac tgccatctgt     5400

tcgagacggc gcgcacatgg gcgtacaggg aggtgcgcca ccactgggga gacagcgagg     5460

ggctgcggct ggccatctcg gccgaggcgc acgaaatgaa cgccgaactg ttccccgagc     5520

cactggcatg gtcggaggtc gagcagatcg ccaagagcat ccacaagtgg atcgtcaccc     5580

aaagccgcat gtggcgcgac ggccccaccg tctacgaggc gacattcatc accgtccaaa     5640

gcgcccgagg gaaaaagtca ggcaaggcca gacgagaaac attcgaacta ttcgcgagcg     5700

aggagatgac gtaa                                                       5714


<210>  44
<211>  8978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFRG3.5-CMV-SGene

<400>  44
atgtgagcaa aaggccagca aaaggccagg gaccgtaaaa aggccgcgtt gctggcgttt       60

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      120

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      180

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      240

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      300

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      360

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      420

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      480

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      540

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      600

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      660

atcttttcta cgggtttttt tggggcggct ttgaattctt ttttttgggg cggctttttt      720

tttatgcgct cacgcaactg gtccagaacc ttgaccgaac gcagcggtgg taacggcgca      780

gtggcggttt tcatggcttg ttatgactgt ttttttgggg tacagtctat gcctcgggca      840

tccaagcagc aagcgcgtta cgccgtgggt cgatgtttga tgttatggag cagcaacgat      900

gttacgcagc agggcagtcg ccctaaaaca aagttaaaca tcatgaggga agcggtgatc      960

gccgaagtat cgactcaact atcagaggta gttggcgtca tcgagcgcca tctcgaaccg     1020

acgttgctgg ccgtacattt gtacggctcc gcagtggatg gcggcctgaa gccacacagt     1080

gatattgatt tgctggttac ggtgaccgta aggcttgatg aaacaacgcg gcgagctttg     1140

atcaacgacc ttttggaaac ttcggcttcc cctggagaga gcgagattct ccgcgctgta     1200

gaagtcacca ttgttgtgca cgacgacatc attccgtggc gttatccagc taagcgcgaa     1260

ctgcaatttg gagaatggca gcgcaatgac attcttgcag gtatcttcga gccagccacg     1320

atcgacattg atctggctat cttgctgaca aaagcaagag aacatagcgt tgccttggta     1380

ggtccagcgg cggaggaact ctttgatccg gttcctgaac aggatctatt tgaggcgcta     1440

aatgaaacct taacgctatg gaactcgccg cccgactggg ctggcgatga gcgaaatgta     1500

gtgcttacgt tgtcccgcat ttggtacagc gcagtaaccg gcaaaatcgc gccgaaggat     1560

gtcgctgccg actgggcaat ggagcgcctg ccggcccagt atcagcccgt catacttgaa     1620

gctagacagg cttatcttgg acaagaagaa gatcgcttgg cctcgcgcgc agatcagttg     1680

gaagaatttg tccactacgt gaaaggcgag atcaccaagg tagtcggcaa ataaggtacc     1740

gttaggcgtt ttcgcgatgt acgggccaga tatacgcgtt gacattgatt attgactagt     1800

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1860

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1920

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1980

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     2040

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     2100

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     2160

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     2220

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     2280

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     2340

tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     2400

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg gactctagag     2460

gatcgaagct agccaccatg tttgtttttc ttgttttatt gccactagtc tctagtcagt     2520

gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg     2580

gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt     2640

tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg     2700

gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca     2760

ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc     2820

agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat     2880

tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa     2940

gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt     3000

ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta     3060

agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg     3120

atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca     3180

tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt     3240

cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt     3300

ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc     3360

ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa     3420

cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact     3480

tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca     3540

ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt     3600

ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg     3660

tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa     3720

ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag     3780

cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat     3840

tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg     3900

ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat     3960

atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt     4020

ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta     4080

aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt     4140

ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg     4200

ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg     4260

tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg     4320

ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg     4380

tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac     4440

atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc     4500

agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct     4560

acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac     4620

ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat     4680

cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc     4740

aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag     4800

acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta     4860

aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga     4920

ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca     4980

aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt     5040

ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt     5100

ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac     5160

aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg     5220

ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc     5280

aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa     5340

atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa     5400

gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata     5460

ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag     5520

ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg     5580

gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt     5640

cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact     5700

tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct     5760

ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca     5820

ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca     5880

acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat     5940

attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt     6000

cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg     6060

aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt     6120

acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt     6180

gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca     6240

aatttgatga agacgactct gagccagtgc tcaaaggagt caaattacat tacacataat     6300

cgatccctac cggttagtaa tgagtttaaa cgggggaggc taactgaaac acggaaggag     6360

acaataccgg aaggaacccg cgctatgacg gcaataaaaa gacagaataa aacgcacggg     6420

tgttgggtcg tttgttcata aacgcggggt tcggtcccag ggctggcact ctgtcgatac     6480

cccaccgaga ccccattggg gccaatacgc ccgcgtttct tccttttccc caccccaccc     6540

cccaagttcg ggtgaaggcc cagggctcgc agccaacgtc ggggcggcag gccctgccat     6600

agctttttgg ggcggctttt ctcgagtcct tccttaagga cgtgctcgtc aatttttgtt     6660

ttgagagtca tctattcgga tgcttttcat gaagtttttt atgaccctga ccggcaccct     6720

gcgcaaggcc ttcgccacca ccctggccgc cgccatgctg atcggcaccc tggccggctg     6780

ctcctccgcc gcatacaaca agtctgacct cgtttcgaag atcgcccaga agtccaacct     6840

gaccaaggct caggccgagg ctgctgttaa cgccttccag gatgtgttcg tcgaggctat     6900

gaagtccggc gaaggcctga agctcaccgg cctgttctcc gctgagcgcg tcaagcgccc     6960

ggctcgcacc ggccgcaacc cgcgcactgg cgagcagatt gacattccgg cttcctacgg     7020

cgttcgtatc tccgctggct ccctgctgaa gaaggccgtc accgagtatg gacggaagaa     7080

gcgcaggcag cgacggcgat gagggtttgc gcttgcgtcg tggagggagc ggaacgccga     7140

aaaaggatcc acgcgctgga gatgttcaac gagtagatcg ccacggcgac ctccttccac     7200

gcgtgcgggc acggggattc tcaaggggcc ggcccgaggc cccttgagcc cgccgggagg     7260

cgcccccggc agggcgggaa tccaaagggc ggagccctgt ggccctcccc gggcaggggc     7320

gggatcgtca agggcggagc ccttggcccc ctcgggagag cgcactgaca caatgctacc     7380

tccggtagca ttaagtgcgc cctccgccat gcggagggac gggccgcgac cggatatgcg     7440

gggaacgtcc acgacgcgtc ttccgtgtcc tccgtcctgc cttgtgccgt cgattataat     7500

cctcggataa cggacgatga ttgaaccgat tggaggaaac gagatgccga agagtttcgc     7560

gcagcagatc gaggacgacg agaacaagat caagcgcatc cgggagcacc agcgcatggt     7620

cagggccaaa caagccaaac aggagcgcaa cgcccgcacc aaaaggctcg tggagaccgg     7680

agcgatagtg gaaaaagcgc acggcggcgc gtacgacgac gaaggacggc agacgttctc     7740

ggatggtctg aacggcatca tctcggtcta cgacccgtcc cgcggcggca acgtggacat     7800

gagagtcatc gacgtaatcg accggcgcat ccccagattg ccaaggtccg aaaccacaac     7860

aggcacggca gcggcggcat cgcgaaccgt gcaagccacc gcaccacagc cagcccacgc     7920

ccaaccgcaa agcttcacgc ccaaccccca gcgcatcgaa caccggacag gagcacagca     7980

gccggatcgg tgggcctagc cgggacggcg cagccctcgc tccgctgggc tgaaatatct     8040

gacttggttc gtaacatatt tccgacatgt cggaaatatg tcgtatcatc gttgctatga     8100

gtactgaact tcgtgagcag tgggagcagc tttacctgcc gctgcgcccg ctgtgcacga     8160

acgacttcat cgagggcgtg taccggcagc ccagggcgaa ggcgctggag ggctaccggt     8220

acatcgaggc gaaccccaag accgtcagcg acctgctcgt ggtcgacatc gacgacgcga     8280

acgcccgcgc gatggcccta tgggagcatg aggggatgct gcccaacgtg atcgtggaga     8340

acccgagaaa cggccacgcg cacgccgtgt gggcgctggc cgccccgttc agtcgcaccg     8400

aatacgcgcg gcgcaagccg ctcgccctgg ccgcggcggt cacggagggg ctgcgccgct     8460

cgtgcgacgg ggacaaggga tattcggggc tgatgaccaa gaacccgctg cacgaggcgt     8520

ggaacagcga actggtcacc gatcacctgt acgggctgga cgaactgcgc gaggcgctgg     8580

aggagtccgg ggacatgccg ccggcctcgt ggaagcgcac gaaacggcgc aacgtggtcg     8640

gattgggccg caactgccat ctgttcgaga cggcgcgcac atgggcgtac agggaggtgc     8700

gccaccactg gggagacagc gaggggctgc ggctggccat ctcggccgag gcgcacgaaa     8760

tgaacgccga actgttcccc gagccactgg catggtcgga ggtcgagcag atcgccaaga     8820

gcatccacaa gtggatcgtc acccaaagcc gcatgtggcg cgacggcccc accgtctacg     8880

aggcgacatt catcaccgtc caaagcgccc gagggaaaaa gtcaggcaag gccagacgag     8940

aaacattcga actattcgcg agcgaggaga tgacgtaa                             8978


<210>  45
<211>  12065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFRG3.5-CMV-COVID19-SiMiN

<400>  45
atgtgagcaa aaggccagca aaaggccagg gaccgtaaaa aggccgcgtt gctggcgttt       60

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      120

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      180

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      240

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      300

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      360

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      420

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      480

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      540

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      600

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      660

atcttttcta cgggtttttt tggggcggct ttgaattctt ttttttgggg cggctttttt      720

tttatgcgct cacgcaactg gtccagaacc ttgaccgaac gcagcggtgg taacggcgca      780

gtggcggttt tcatggcttg ttatgactgt ttttttgggg tacagtctat gcctcgggca      840

tccaagcagc aagcgcgtta cgccgtgggt cgatgtttga tgttatggag cagcaacgat      900

gttacgcagc agggcagtcg ccctaaaaca aagttaaaca tcatgaggga agcggtgatc      960

gccgaagtat cgactcaact atcagaggta gttggcgtca tcgagcgcca tctcgaaccg     1020

acgttgctgg ccgtacattt gtacggctcc gcagtggatg gcggcctgaa gccacacagt     1080

gatattgatt tgctggttac ggtgaccgta aggcttgatg aaacaacgcg gcgagctttg     1140

atcaacgacc ttttggaaac ttcggcttcc cctggagaga gcgagattct ccgcgctgta     1200

gaagtcacca ttgttgtgca cgacgacatc attccgtggc gttatccagc taagcgcgaa     1260

ctgcaatttg gagaatggca gcgcaatgac attcttgcag gtatcttcga gccagccacg     1320

atcgacattg atctggctat cttgctgaca aaagcaagag aacatagcgt tgccttggta     1380

ggtccagcgg cggaggaact ctttgatccg gttcctgaac aggatctatt tgaggcgcta     1440

aatgaaacct taacgctatg gaactcgccg cccgactggg ctggcgatga gcgaaatgta     1500

gtgcttacgt tgtcccgcat ttggtacagc gcagtaaccg gcaaaatcgc gccgaaggat     1560

gtcgctgccg actgggcaat ggagcgcctg ccggcccagt atcagcccgt catacttgaa     1620

gctagacagg cttatcttgg acaagaagaa gatcgcttgg cctcgcgcgc agatcagttg     1680

gaagaatttg tccactacgt gaaaggcgag atcaccaagg tagtcggcaa ataaggtacc     1740

gttaggcgtt ttcgcgatgt acgggccaga tatacgcgtt gacattgatt attgactagt     1800

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1860

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1920

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1980

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     2040

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     2100

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     2160

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     2220

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     2280

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     2340

tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     2400

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg gactctagag     2460

gatcgaagct agccaccatg tttgtttttc ttgttttatt gccactagtc tctagtcagt     2520

gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg     2580

gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt     2640

tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg     2700

gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca     2760

ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc     2820

agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat     2880

tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa     2940

gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt     3000

ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta     3060

agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg     3120

atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca     3180

tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt     3240

cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt     3300

ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc     3360

ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa     3420

cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact     3480

tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca     3540

ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt     3600

ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg     3660

tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa     3720

ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag     3780

cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat     3840

tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg     3900

ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat     3960

atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt     4020

ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta     4080

aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt     4140

ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg     4200

ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg     4260

tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg     4320

ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg     4380

tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac     4440

atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc     4500

agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct     4560

acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac     4620

ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat     4680

cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc     4740

aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag     4800

acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta     4860

aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga     4920

ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca     4980

aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt     5040

ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt     5100

ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac     5160

aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg     5220

ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc     5280

aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa     5340

atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa     5400

gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata     5460

ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag     5520

ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg     5580

gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt     5640

cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact     5700

tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct     5760

ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca     5820

ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca     5880

acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat     5940

attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt     6000

cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg     6060

aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt     6120

acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt     6180

gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca     6240

aatttgatga agacgactct gagccagtgc tcaaaggagt caaattacat tacacataac     6300

gccccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt     6360

ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg     6420

ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg     6480

tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc     6540

tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca     6600

aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag     6660

ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa     6720

ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt gcacatgctt     6780

tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     6840

tttcctttga aaaacacgat gataatatgg ccacaaccat ggcagattcc aacggtacta     6900

ttaccgttga agagcttaaa aagctccttg aacaatggaa cctagtaata ggtttcctat     6960

tccttacatg gatttgtctt ctacaatttg cctatgccaa caggaatagg tttttgtata     7020

taattaagtt aattttcctc tggctgttat ggccagtaac tttagcttgt tttgtgcttg     7080

ctgctgttta cagaataaat tggatcaccg gtggaattgc tatcgcaatg gcttgtcttg     7140

taggcttgat gtggctcagc tacttcattg cttctttcag actgtttgcg cgtacgcgtt     7200

ccatgtggtc attcaatcca gaaactaaca ttcttctcaa cgtgccactc catggcacta     7260

ttctgaccag accgcttcta gaaagtgaac tcgtaatcgg agctgtgatc cttcgtggac     7320

atcttcgtat tgctggacac catctaggac gctgtgacat caaggacctg cctaaagaaa     7380

tcactgttgc tacatcacga acgctttctt attacaaatt gggagcttcg cagcgtgtag     7440

caggtgactc aggttttgct gcatacagtc gctacaggat tggcaactat aaattaaaca     7500

cagaccattc cagtagcagt gacaatattg ctttgcttgt acagtaacgc cccccccccc     7560

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     7620

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     7680

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     7740

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     7800

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     7860

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     7920

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     7980

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     8040

gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa     8100

aacacgatga taatatggcc acaaccatgt ctgataatgg accccaaaat cagcgaaatg     8160

caccccgcat tacgtttggt ggaccctcag attcaactgg cagtaaccag aatggagaac     8220

gcagtggggc gcgatcaaaa caacgtcggc cccaaggttt acccaataat actgcgtctt     8280

ggttcaccgc tctcactcaa catggcaagg aagaccttaa attccctcga ggacaaggcg     8340

ttccaattaa caccaatagc agtccagatg accaaattgg ctactaccga agagctacca     8400

gacgaattcg tggtggtgac ggtaaaatga aagatctcag tccaagatgg tatttctact     8460

acctaggaac tgggccagaa gctggacttc cctatggtgc taacaaagac ggcatcatat     8520

gggttgcaac tgagggagcc ttgaatacac caaaagatca cattggcacc cgcaatcctg     8580

ctaacaatgc tgcaatcgtg ctacaacttc ctcaaggaac aacattgcca aaaggcttct     8640

acgcagaagg gagcagaggc ggcagtcaag cctcttctcg ttcctcatca cgtagtcgca     8700

acagttcaag aaattcaact ccaggcagca gtaggggaac ttctcctgct agaatggctg     8760

gcaatggcgg tgatgctgct cttgctttgc tgctgcttga cagattgaac cagcttgaga     8820

gcaaaatgtc tggtaaaggc caacaacaac aaggccaaac tgtcactaag aaatctgctg     8880

ctgaggcttc taagaagcct cggcaaaaac gtactgccac taaagcatac aatgtaacac     8940

aagctttcgg cagacgtggt ccagaacaaa cccaaggaaa ttttggggac caggaactaa     9000

tcagacaagg aactgattac aaacattggc cgcaaattgc acaatttgcc cccagcgctt     9060

cagcgttctt cggaatgtcg cgcattggca tggaagtcac accttcggga acgtggttga     9120

cctacacagg tgccatcaaa ttggatgaca aagatccaaa tttcaaagat caagtcattt     9180

tgctgaataa gcatattgac gcatacaaaa cattcccacc aacagagcct aaaaaggaca     9240

aaaagaagaa ggctgatgaa actcaagcct taccgcagag acagaagaaa cagcaaactg     9300

tgactcttct tcctgctgca gatttggatg atttctccaa acaattgcaa caatccatga     9360

gcagtgctga ctcaactcag gcctaatcga tccctaccgg ttagtaatga gtttaaacgg     9420

gggaggctaa ctgaaacacg gaaggagaca ataccggaag gaacccgcgc tatgacggca     9480

ataaaaagac agaataaaac gcacgggtgt tgggtcgttt gttcataaac gcggggttcg     9540

gtcccagggc tggcactctg tcgatacccc accgagaccc cattggggcc aatacgcccg     9600

cgtttcttcc ttttccccac cccacccccc aagttcgggt gaaggcccag ggctcgcagc     9660

caacgtcggg gcggcaggcc ctgccatagc tttttggggc ggcttttctc gagtccttcc     9720

ttaaggacgt gctcgtcaat ttttgttttg agagtcatct attcggatgc ttttcatgaa     9780

gttttttatg accctgaccg gcaccctgcg caaggccttc gccaccaccc tggccgccgc     9840

catgctgatc ggcaccctgg ccggctgctc ctccgccgca tacaacaagt ctgacctcgt     9900

ttcgaagatc gcccagaagt ccaacctgac caaggctcag gccgaggctg ctgttaacgc     9960

cttccaggat gtgttcgtcg aggctatgaa gtccggcgaa ggcctgaagc tcaccggcct    10020

gttctccgct gagcgcgtca agcgcccggc tcgcaccggc cgcaacccgc gcactggcga    10080

gcagattgac attccggctt cctacggcgt tcgtatctcc gctggctccc tgctgaagaa    10140

ggccgtcacc gagtatggac ggaagaagcg caggcagcga cggcgatgag ggtttgcgct    10200

tgcgtcgtgg agggagcgga acgccgaaaa aggatccacg cgctggagat gttcaacgag    10260

tagatcgcca cggcgacctc cttccacgcg tgcgggcacg gggattctca aggggccggc    10320

ccgaggcccc ttgagcccgc cgggaggcgc ccccggcagg gcgggaatcc aaagggcgga    10380

gccctgtggc cctccccggg caggggcggg atcgtcaagg gcggagccct tggccccctc    10440

gggagagcgc actgacacaa tgctacctcc ggtagcatta agtgcgccct ccgccatgcg    10500

gagggacggg ccgcgaccgg atatgcgggg aacgtccacg acgcgtcttc cgtgtcctcc    10560

gtcctgcctt gtgccgtcga ttataatcct cggataacgg acgatgattg aaccgattgg    10620

aggaaacgag atgccgaaga gtttcgcgca gcagatcgag gacgacgaga acaagatcaa    10680

gcgcatccgg gagcaccagc gcatggtcag ggccaaacaa gccaaacagg agcgcaacgc    10740

ccgcaccaaa aggctcgtgg agaccggagc gatagtggaa aaagcgcacg gcggcgcgta    10800

cgacgacgaa ggacggcaga cgttctcgga tggtctgaac ggcatcatct cggtctacga    10860

cccgtcccgc ggcggcaacg tggacatgag agtcatcgac gtaatcgacc ggcgcatccc    10920

cagattgcca aggtccgaaa ccacaacagg cacggcagcg gcggcatcgc gaaccgtgca    10980

agccaccgca ccacagccag cccacgccca accgcaaagc ttcacgccca acccccagcg    11040

catcgaacac cggacaggag cacagcagcc ggatcggtgg gcctagccgg gacggcgcag    11100

ccctcgctcc gctgggctga aatatctgac ttggttcgta acatatttcc gacatgtcgg    11160

aaatatgtcg tatcatcgtt gctatgagta ctgaacttcg tgagcagtgg gagcagcttt    11220

acctgccgct gcgcccgctg tgcacgaacg acttcatcga gggcgtgtac cggcagccca    11280

gggcgaaggc gctggagggc taccggtaca tcgaggcgaa ccccaagacc gtcagcgacc    11340

tgctcgtggt cgacatcgac gacgcgaacg cccgcgcgat ggccctatgg gagcatgagg    11400

ggatgctgcc caacgtgatc gtggagaacc cgagaaacgg ccacgcgcac gccgtgtggg    11460

cgctggccgc cccgttcagt cgcaccgaat acgcgcggcg caagccgctc gccctggccg    11520

cggcggtcac ggaggggctg cgccgctcgt gcgacgggga caagggatat tcggggctga    11580

tgaccaagaa cccgctgcac gaggcgtgga acagcgaact ggtcaccgat cacctgtacg    11640

ggctggacga actgcgcgag gcgctggagg agtccgggga catgccgccg gcctcgtgga    11700

agcgcacgaa acggcgcaac gtggtcggat tgggccgcaa ctgccatctg ttcgagacgg    11760

cgcgcacatg ggcgtacagg gaggtgcgcc accactgggg agacagcgag gggctgcggc    11820

tggccatctc ggccgaggcg cacgaaatga acgccgaact gttccccgag ccactggcat    11880

ggtcggaggt cgagcagatc gccaagagca tccacaagtg gatcgtcacc caaagccgca    11940

tgtggcgcga cggccccacc gtctacgagg cgacattcat caccgtccaa agcgcccgag    12000

ggaaaaagtc aggcaaggcc agacgagaaa cattcgaact attcgcgagc gaggagatga    12060

cgtaa                                                                12065


<210>  46
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  46

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  47
<211>  222
<212>  PRT
<213>  SARS-CoV-2

<400>  47

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          


Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              


Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  


Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile 
65                  70                  75                  80  


Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      


Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         


Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile 
        115                 120                 125             


Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 


Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp 
145                 150                 155                 160 


Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     


Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly 
            180                 185                 190         


Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             


Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         


<210>  48
<211>  419
<212>  PRT
<213>  SARS-CoV-2

<400>  48

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  49
<211>  8978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of pFRG-CMV-Sgene

<400>  49
atgtgagcaa aaggccagca aaaggccagg gaccgtaaaa aggccgcgtt gctggcgttt       60

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      120

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      180

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      240

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      300

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      360

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      420

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      480

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc      540

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt      600

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg      660

atcttttcta cgggtttttt tggggcggct ttgaattctt ttttttgggg cggctttttt      720

tttatgcgct cacgcaactg gtccagaacc ttgaccgaac gcagcggtgg taacggcgca      780

gtggcggttt tcatggcttg ttatgactgt ttttttgggg tacagtctat gcctcgggca      840

tccaagcagc aagcgcgtta cgccgtgggt cgatgtttga tgttatggag cagcaacgat      900

gttacgcagc agggcagtcg ccctaaaaca aagttaaaca tcatgaggga agcggtgatc      960

gccgaagtat cgactcaact atcagaggta gttggcgtca tcgagcgcca tctcgaaccg     1020

acgttgctgg ccgtacattt gtacggctcc gcagtggatg gcggcctgaa gccacacagt     1080

gatattgatt tgctggttac ggtgaccgta aggcttgatg aaacaacgcg gcgagctttg     1140

atcaacgacc ttttggaaac ttcggcttcc cctggagaga gcgagattct ccgcgctgta     1200

gaagtcacca ttgttgtgca cgacgacatc attccgtggc gttatccagc taagcgcgaa     1260

ctgcaatttg gagaatggca gcgcaatgac attcttgcag gtatcttcga gccagccacg     1320

atcgacattg atctggctat cttgctgaca aaagcaagag aacatagcgt tgccttggta     1380

ggtccagcgg cggaggaact ctttgatccg gttcctgaac aggatctatt tgaggcgcta     1440

aatgaaacct taacgctatg gaactcgccg cccgactggg ctggcgatga gcgaaatgta     1500

gtgcttacgt tgtcccgcat ttggtacagc gcagtaaccg gcaaaatcgc gccgaaggat     1560

gtcgctgccg actgggcaat ggagcgcctg ccggcccagt atcagcccgt catacttgaa     1620

gctagacagg cttatcttgg acaagaagaa gatcgcttgg cctcgcgcgc agatcagttg     1680

gaagaatttg tccactacgt gaaaggcgag atcaccaagg tagtcggcaa ataaggtacc     1740

gttaggcgtt ttcgcgatgt acgggccaga tatacgcgtt gacattgatt attgactagt     1800

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     1860

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     1920

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     1980

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     2040

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     2100

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg     2160

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt     2220

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac     2280

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg     2340

tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat     2400

ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg gactctagag     2460

gatcgaagct agccaccatg tttgtttttc ttgttttatt gccactagtc tctagtcagt     2520

gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg     2580

gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt     2640

tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg     2700

gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca     2760

ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc     2820

agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat     2880

tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa     2940

gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt     3000

ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta     3060

agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg     3120

atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca     3180

tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt     3240

cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt     3300

ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc     3360

ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa     3420

cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact     3480

tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca     3540

ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt     3600

ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg     3660

tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa     3720

ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag     3780

cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat     3840

tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg     3900

ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat     3960

atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt     4020

ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta     4080

aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt     4140

ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg     4200

ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg     4260

tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg     4320

ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg     4380

tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac     4440

atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc     4500

agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct     4560

acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac     4620

ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat     4680

cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc     4740

aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag     4800

acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta     4860

aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga     4920

ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca     4980

aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt     5040

ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt     5100

ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac     5160

aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg     5220

ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc     5280

aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa     5340

atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa     5400

gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata     5460

ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag     5520

ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg     5580

gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt     5640

cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact     5700

tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct     5760

ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca     5820

ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca     5880

acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat     5940

attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt     6000

cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg     6060

aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt     6120

acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt     6180

gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca     6240

aatttgatga agacgactct gagccagtgc tcaaaggagt caaattacat tacacataat     6300

cgatccctac cggttagtaa tgagtttaaa cgggggaggc taactgaaac acggaaggag     6360

acaataccgg aaggaacccg cgctatgacg gcaataaaaa gacagaataa aacgcacggg     6420

tgttgggtcg tttgttcata aacgcggggt tcggtcccag ggctggcact ctgtcgatac     6480

cccaccgaga ccccattggg gccaatacgc ccgcgtttct tccttttccc caccccaccc     6540

cccaagttcg ggtgaaggcc cagggctcgc agccaacgtc ggggcggcag gccctgccat     6600

agctttttgg ggcggctttt ctcgagtcct tccttaagga cgtgctcgtc aatttttgtt     6660

ttgagagtca tctattcgga tgcttttcat gaagtttttt atgaccctga ccggcaccct     6720

gcgcaaggcc ttcgccacca ccctggccgc cgccatgctg atcggcaccc tggccggctg     6780

ctcctccgcc gcatacaaca agtctgacct cgtttcgaag atcgcccaga agtccaacct     6840

gaccaaggct caggccgagg ctgctgttaa cgccttccag gatgtgttcg tcgaggctat     6900

gaagtccggc gaaggcctga agctcaccgg cctgttctcc gctgagcgcg tcaagcgccc     6960

ggctcgcacc ggccgcaacc cgcgcactgg cgagcagatt gacattccgg cttcctacgg     7020

cgttcgtatc tccgctggct ccctgctgaa gaaggccgtc accgagtatg gacggaagaa     7080

gcgcaggcag cgacggcgat gagggtttgc gcttgcgtcg tggagggagc ggaacgccga     7140

aaaaggatcc acgcgctgga gatgttcaac gagtagatcg ccacggcgac ctccttccac     7200

gcgtgcgggc acggggattc tcaaggggcc ggcccgaggc cccttgagcc cgccgggagg     7260

cgcccccggc agggcgggaa tccaaagggc ggagccctgt ggccctcccc gggcaggggc     7320

gggatcgtca agggcggagc ccttggcccc ctcgggagag cgcactgaca caatgctacc     7380

tccggtagca ttaagtgcgc cctccgccat gcggagggac gggccgcgac cggatatgcg     7440

gggaacgtcc acgacgcgtc ttccgtgtcc tccgtcctgc cttgtgccgt cgattataat     7500

cctcggataa cggacgatga ttgaaccgat tggaggaaac gagatgccga agagtttcgc     7560

gcagcagatc gaggacgacg agaacaagat caagcgcatc cgggagcacc agcgcatggt     7620

cagggccaaa caagccaaac aggagcgcaa cgcccgcacc aaaaggctcg tggagaccgg     7680

agcgatagtg gaaaaagcgc acggcggcgc gtacgacgac gaaggacggc agacgttctc     7740

ggatggtctg aacggcatca tctcggtcta cgacccgtcc cgcggcggca acgtggacat     7800

gagagtcatc gacgtaatcg accggcgcat ccccagattg ccaaggtccg aaaccacaac     7860

aggcacggca gcggcggcat cgcgaaccgt gcaagccacc gcaccacagc cagcccacgc     7920

ccaaccgcaa agcttcacgc ccaaccccca gcgcatcgaa caccggacag gagcacagca     7980

gccggatcgg tgggcctagc cgggacggcg cagccctcgc tccgctgggc tgaaatatct     8040

gacttggttc gtaacatatt tccgacatgt cggaaatatg tcgtatcatc gttgctatga     8100

gtactgaact tcgtgagcag tgggagcagc tttacctgcc gctgcgcccg ctgtgcacga     8160

acgacttcat cgagggcgtg taccggcagc ccagggcgaa ggcgctggag ggctaccggt     8220

acatcgaggc gaaccccaag accgtcagcg acctgctcgt ggtcgacatc gacgacgcga     8280

acgcccgcgc gatggcccta tgggagcatg aggggatgct gcccaacgtg atcgtggaga     8340

acccgagaaa cggccacgcg cacgccgtgt gggcgctggc cgccccgttc agtcgcaccg     8400

aatacgcgcg gcgcaagccg ctcgccctgg ccgcggcggt cacggagggg ctgcgccgct     8460

cgtgcgacgg ggacaaggga tattcggggc tgatgaccaa gaacccgctg cacgaggcgt     8520

ggaacagcga actggtcacc gatcacctgt acgggctgga cgaactgcgc gaggcgctgg     8580

aggagtccgg ggacatgccg ccggcctcgt ggaagcgcac gaaacggcgc aacgtggtcg     8640

gattgggccg caactgccat ctgttcgaga cggcgcgcac atgggcgtac agggaggtgc     8700

gccaccactg gggagacagc gaggggctgc ggctggccat ctcggccgag gcgcacgaaa     8760

tgaacgccga actgttcccc gagccactgg catggtcgga ggtcgagcag atcgccaaga     8820

gcatccacaa gtggatcgtc acccaaagcc gcatgtggcg cgacggcccc accgtctacg     8880

aggcgacatt catcaccgtc caaagcgccc gagggaaaaa gtcaggcaag gccagacgag     8940

aaacattcga actattcgcg agcgaggaga tgacgtaa                             8978


<210>  50
<211>  223
<212>  PRT
<213>  SARS-CoV-2

<400>  50

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  51
<211>  72
<212>  PRT
<213>  SARS-CoV-2

<400>  51

Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
1               5                   10                  15      


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
            20                  25                  30          


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
        35                  40                  45              


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
    50                  55                  60                  


Asn Gly Val Gly Tyr Gln Pro Tyr 
65                  70          


<210>  52
<211>  1261
<212>  PRT
<213>  SARS-Cov-2

<400>  52

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
        675                 680                 685             


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
    690                 695                 700                 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
705                 710                 715                 720 


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
                725                 730                 735     


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
            740                 745                 750         


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
        755                 760                 765             


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
    770                 775                 780                 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
785                 790                 795                 800 


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
                805                 810                 815     


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
            820                 825                 830         


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
        835                 840                 845             


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
    850                 855                 860                 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
865                 870                 875                 880 


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
                885                 890                 895     


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
            900                 905                 910         


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
        915                 920                 925             


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
    930                 935                 940                 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
945                 950                 955                 960 


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
                965                 970                 975     


Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu 
            980                 985                 990         


Gln Thr Tyr Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
        995                 1000                 1005             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1010                 1015                 1020             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1025                 1030                 1035             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1040                 1045                 1050             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1055                 1060                 1065             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1070                 1075                 1080             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1085                 1090                 1095             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1100                 1105                 1110             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1115                 1120                 1125             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1130                 1135                 1140             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1145                 1150                 1155             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1160                 1165                 1170             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1175                 1180                 1185             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1190                 1195                 1200             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1205                 1210                 1215             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1220                 1225                 1230             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1235                 1240                 1245             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255                 1260     


<210>  53
<211>  1270
<212>  PRT
<213>  SARS-CoV-2 variant

<400>  53

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  54
<211>  223
<212>  PRT
<213>  SARS-CoV-2 variant

<400>  54

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  55
<211>  71
<212>  PRT
<213>  SARS-CoV2 variant

<400>  55

Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
1               5                   10                  15      


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
            20                  25                  30          


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly 
        35                  40                  45              


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr 
    50                  55                  60                  


Gly Val Gly Tyr Gln Pro Tyr 
65                  70      


<210>  56
<211>  1258
<212>  PRT
<213>  SARS-CoV2 variant

<400>  56

Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1220                 1225                 1230             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1235                 1240                 1245             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1250                 1255             


