                         SEQUENCE LISTING

<110>  Hertz, Nicholas
       Rakhit, Rishi
       Ditsworth, Dara
       Bartholomeus, Johan
       Johnstone, Shawn
       Chin, Randall Marcelo
       Devita, Robert
       McGee, Philippe
       Dansereau, Julien
 
<120>  COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF 
       NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

<130>  37930.0006P1

<150>  US 62/980,143
<151>  2020-02-21

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly 
            20                  25                  30          


Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp 
        35                  40                  45              


Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro 
    50                  55                  60                  


Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  


Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys 
                85                  90                  95      


Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         


Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile 
        115                 120                 125             


Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp 
    130                 135                 140                 


Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln 
145                 150                 155                 160 


Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     


Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro 
            180                 185                 190         


Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala 
        195                 200                 205             


Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile 
    210                 215                 220                 


Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu 
225                 230                 235                 240 


Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val 
                245                 250                 255     


Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro 
            260                 265                 270         


Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu 
        275                 280                 285             


Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His 
    290                 295                 300                 


Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn 
305                 310                 315                 320 


Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro 
                325                 330                 335     


Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His 
            340                 345                 350         


Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile 
        355                 360                 365             


Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp 
    370                 375                 380                 


Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe 
385                 390                 395                 400 


Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro 
                405                 410                 415     


Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser 
            420                 425                 430         


Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly 
        435                 440                 445             


Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg 
    450                 455                 460                 


Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro 
465                 470                 475                 480 


Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys 
                485                 490                 495     


Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp 
            500                 505                 510         


Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val 
        515                 520                 525             


Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu 
    530                 535                 540                 


Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala 
545                 550                 555                 560 


Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser 
                565                 570                 575     


Trp Arg Ala Ala Leu 
            580     


<210>  2
<211>  580
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Ala Pro Lys Pro Gly Pro Leu Phe Gly Trp Gly 
            20                  25                  30          


Lys Pro Gly Pro Ala Ala Ala Trp Gly Arg Gly Glu Arg Pro Gly Gln 
        35                  40                  45              


Val Val Ser Pro Gly Ala Gln Pro Arg Pro Val Gly Leu Pro Leu Pro 
    50                  55                  60                  


Asp Arg Tyr Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  


Ile Gln Arg Gln Phe Met Val Arg Ala Arg Gly Gly Ala Gly Pro Cys 
                85                  90                  95      


Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         


Glu Lys Gln Ala Glu Gly Arg Arg Ala Ala Ser Ala Cys Gln Glu Ile 
        115                 120                 125             


Gln Ala Ile Phe Thr Gln Lys Thr Lys Arg Val Ser Asp Pro Leu Asp 
    130                 135                 140                 


Thr Arg Cys Trp Gln Gly Phe Arg Leu Glu Asp Tyr Leu Ile Gly Gln 
145                 150                 155                 160 


Ala Ile Gly Lys Gly Cys Asn Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     


Thr Leu Pro Gln His Leu Glu Lys Ala Lys His Leu Gly Leu Ile Gly 
            180                 185                 190         


Lys Gly Pro Asp Val Val Leu Lys Gly Ala Asp Gly Glu Gln Ala Pro 
        195                 200                 205             


Gly Thr Pro Thr Phe Pro Phe Ala Ile Lys Met Met Trp Asn Ile Ser 
    210                 215                 220                 


Ala Gly Ser Ser Ser Glu Ala Ile Leu Ser Lys Met Ser Gln Glu Leu 
225                 230                 235                 240 


Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val Thr 
                245                 250                 255     


Tyr Arg Arg Ser Arg Asp Gly Pro Lys Gln Leu Ala Pro His Pro Asn 
            260                 265                 270         


Ile Ile Arg Val Phe Arg Ala Phe Thr Ser Ser Val Pro Leu Leu Pro 
        275                 280                 285             


Gly Ala Leu Ala Asp Tyr Pro Asp Met Leu Pro Pro His Tyr Tyr Pro 
    290                 295                 300                 


Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn Tyr 
305                 310                 315                 320 


Pro Cys Thr Leu Arg Gln Tyr Leu Glu Glu Gln Thr Pro Ser Ser Arg 
                325                 330                 335     


Leu Ala Thr Met Met Thr Leu Gln Leu Leu Glu Gly Val Asp His Leu 
            340                 345                 350         


Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile Leu 
        355                 360                 365             


Val Glu Trp Asp Ser Asp Gly Cys Pro Trp Leu Val Ile Ser Asp Phe 
    370                 375                 380                 


Gly Cys Cys Leu Ala Asp Gln His Val Gly Leu Arg Leu Pro Phe Asn 
385                 390                 395                 400 


Ser Ser Ser Val Glu Arg Gly Gly Asn Gly Ser Leu Met Ala Pro Glu 
                405                 410                 415     


Val Ser Thr Ala His Ser Gly Pro Ser Ala Val Ile Asp Tyr Ser Lys 
            420                 425                 430         


Ala Asp Thr Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly Leu 
        435                 440                 445             


Ala Asn Pro Phe Tyr Gly Gln Gly Ser Ala His Leu Glu Ser Arg Ser 
    450                 455                 460                 


Tyr Gln Glu Ala Gln Leu Pro Glu Met Pro Glu Ser Val Pro Pro Glu 
465                 470                 475                 480 


Ala Arg Arg Leu Val Arg Ser Leu Leu Gln Arg Glu Ala Ser Lys Arg 
                485                 490                 495     


Pro Ser Ala Arg Leu Ala Ala Asn Val Leu His Leu Ser Leu Trp Gly 
            500                 505                 510         


Glu His Leu Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Ile Ala 
        515                 520                 525             


Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asp Arg Leu Arg 
    530                 535                 540                 


Glu Lys Ser Cys Val Glu Thr Lys Leu Gln Met Leu Phe Leu Ala Asn 
545                 550                 555                 560 


Leu Glu Cys Glu Ala Leu Cys Gln Ala Ala Leu Leu Leu Ser Ser Trp 
                565                 570                 575     


Arg Ala Ala Pro 
            580 


<210>  3
<211>  580
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Ala Pro Lys Pro Gly Pro Val Ser Gly Trp Gly 
            20                  25                  30          


Lys Pro Gly Pro Gly Ala Ala Trp Gly Arg Gly Glu Arg Pro Gly Arg 
        35                  40                  45              


Val Ser Ser Pro Gly Ala Gln Pro Arg Pro Leu Gly Leu Pro Leu Pro 
    50                  55                  60                  


Asp Arg Tyr Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  


Ile Gln Arg Gln Phe Val Val Arg Ala Arg Gly Gly Ala Gly Pro Cys 
                85                  90                  95      


Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         


Glu Lys Gln Ala Glu Ser Arg Arg Ala Ala Ser Ala Cys Gln Glu Ile 
        115                 120                 125             


Gln Ala Ile Phe Thr Gln Lys Asn Lys Gln Val Ser Asp Pro Leu Asp 
    130                 135                 140                 


Thr Arg Arg Trp Gln Gly Phe Arg Leu Glu Asp Tyr Leu Ile Gly Gln 
145                 150                 155                 160 


Ala Ile Gly Lys Gly Cys Asn Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     


Thr Leu Pro Gln His Leu Glu Lys Ala Lys His Leu Gly Leu Leu Gly 
            180                 185                 190         


Lys Gly Pro Asp Val Val Ser Lys Gly Ala Asp Gly Glu Gln Ala Pro 
        195                 200                 205             


Gly Ala Pro Ala Phe Pro Phe Ala Ile Lys Met Met Trp Asn Ile Ser 
    210                 215                 220                 


Ala Gly Ser Ser Ser Glu Ala Ile Leu Ser Lys Met Ser Gln Glu Leu 
225                 230                 235                 240 


Val Pro Ala Ser Arg Met Ala Leu Asp Gly Glu Tyr Gly Ala Val Thr 
                245                 250                 255     


Tyr Arg Arg Ser Arg Asp Gly Pro Lys Gln Leu Ala Pro His Pro Asn 
            260                 265                 270         


Ile Ile Arg Val Phe Arg Ala Phe Thr Ser Ser Val Pro Leu Leu Pro 
        275                 280                 285             


Gly Ala Leu Ala Asp Tyr Pro Asp Met Leu Pro Pro His Tyr Tyr Pro 
    290                 295                 300                 


Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn Tyr 
305                 310                 315                 320 


Pro Cys Thr Leu Arg Gln Tyr Leu Glu Glu Gln Thr Pro Ser Ser Arg 
                325                 330                 335     


Leu Ala Thr Met Met Thr Leu Gln Leu Leu Glu Gly Val Asp His Leu 
            340                 345                 350         


Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile Leu 
        355                 360                 365             


Val Glu Trp Asp Ser Asp Gly Cys Pro Trp Leu Val Ile Ser Asp Phe 
    370                 375                 380                 


Gly Cys Cys Leu Ala Asp Glu Arg Val Gly Leu Gln Leu Pro Phe Asn 
385                 390                 395                 400 


Ser Ser Ser Val Glu Arg Gly Gly Asn Gly Ser Leu Met Ala Pro Glu 
                405                 410                 415     


Val Ser Thr Ala His Ser Gly Pro His Ala Val Ile Asp Tyr Ser Lys 
            420                 425                 430         


Ala Asp Thr Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly Leu 
        435                 440                 445             


Ala Asn Pro Phe Tyr Gly Gln Gly Ser Ala His Leu Glu Ser Arg Ser 
    450                 455                 460                 


Tyr Gln Glu Ala Gln Leu Pro Glu Met Pro Lys Ser Val Pro Pro Glu 
465                 470                 475                 480 


Thr Arg Gln Leu Val Arg Ser Leu Leu Gln Arg Glu Ala Asn Lys Arg 
                485                 490                 495     


Pro Ser Ala Arg Ile Ala Ala Asn Val Leu His Leu Ser Leu Trp Gly 
            500                 505                 510         


Glu His Leu Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Ile Ala 
        515                 520                 525             


Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asp Arg Leu Arg 
    530                 535                 540                 


Glu Lys Ser Cys Val Glu Thr Lys Leu Gln Met Leu Phe Leu Ala Asn 
545                 550                 555                 560 


Leu Glu Cys Glu Ala Leu Cys Gln Ala Ala Leu Leu Leu Ser Ser Trp 
                565                 570                 575     


Arg Ala Ala Pro 
            580 


<210>  4
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Gly Thr Gly Thr Thr Gly Gly Gly Ala Thr Thr Cys Gly Gly Cys Thr 
1               5                   10                  15      


Thr Gly Gly Thr 
            20  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5

Gly Thr Cys Cys Ala Thr Gly Cys Ala Cys Thr Thr Gly Thr Cys Gly 
1               5                   10                  15      


Ala Gly Gly Thr Cys 
            20      


<210>  6
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Gly Ala Gly Gly Ala Thr Thr Thr Thr Gly Cys Thr Ala Ala Cys Cys 
1               5                   10                  15      


Thr Gly Ala Cys Ala Cys Cys 
            20              


<210>  7
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7

Thr Thr Gly Ala Cys Gly Gly Thr Ala Ala Cys Thr Gly Ala Cys Thr 
1               5                   10                  15      


Cys Cys Ala Gly Cys 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8

Gly Cys Ala Cys Ala Thr Cys Cys Ala Thr Cys Gly Gly Thr Cys Ala 
1               5                   10                  15      


Thr Cys Cys Ala Gly 
            20      


<210>  9
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9

Gly Cys Cys Ala Cys Ala Gly Thr Cys Ala Ala Ala Cys Cys Thr Thr 
1               5                   10                  15      


Cys Thr Thr Cys Ala Ala 
            20          


<210>  10
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10

Cys Thr Gly Gly Cys Ala Ala Thr Gly Cys Cys Thr Gly Ala Ala Cys 
1               5                   10                  15      


Ala Ala Cys Gly 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11

Gly Gly Thr Cys Gly Gly Gly Ala Cys Thr Thr Gly Gly Thr Thr Cys 
1               5                   10                  15      


Thr Gly Ala Gly 
            20  


<210>  12
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12

Gly Gly Gly Cys Ala Thr Cys Cys Thr Gly Ala Cys Cys Cys Thr Cys 
1               5                   10                  15      


Ala Ala Gly 
            


<210>  13
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13

Thr Cys Cys Ala Thr Gly Thr Cys Gly Thr Cys Cys Cys Ala Gly Thr 
1               5                   10                  15      


Thr Gly Gly Thr 
            20  


<210>  14
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14

Cys Cys Gly Cys Ala Ala Gly Gly Gly Ala Ala Ala Gly Ala Thr Gly 
1               5                   10                  15      


Ala Ala Ala Gly Ala Cys 
            20          


<210>  15
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15

Thr Cys Gly Thr Thr Thr Gly Gly Thr Thr Thr Cys Gly Gly Gly Gly 
1               5                   10                  15      


Thr Thr Thr Cys 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16

Cys Thr Ala Gly Cys Ala Gly Ala Ala Ala Cys Ala Ala Ala Cys Cys 
1               5                   10                  15      


Gly Gly Gly Cys 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17

Cys Cys Gly Gly Cys Thr Gly Cys Gly Thr Ala Thr Thr Cys Thr Ala 
1               5                   10                  15      


Cys Gly Thr Thr 
            20  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18

Gly Cys Cys Ala Gly Cys Cys Thr Cys Thr Cys Cys Thr Gly Ala Thr 
1               5                   10                  15      


Thr Thr Thr Ala Gly Thr Gly Thr 
            20                  


<210>  19
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19

Gly Gly Gly Ala Ala Cys Ala Cys Ala Ala Ala Ala Gly Ala Cys Cys 
1               5                   10                  15      


Thr Cys Thr Thr Cys Thr Gly Gly 
            20                  


