                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
       Michael, Freeman F.
 
<120>  NOVEL METHODS FOR CREATING ALPHA-N-METHYLATED POLYPEPTIDES

<130>  920171.00406

<150>  62/979,947
<151>  2020-02-21

<160>  229   

<170>  PatentIn version 3.5

<210>  1
<211>  263
<212>  PRT
<213>  Shewanella oneidensis

<400>  1

Met Gly Ser Leu Val Cys Val Gly Thr Gly Leu Gln Leu Ala Gly Gln 
1               5                   10                  15      


Ile Ser Val Leu Ser Arg Ser Tyr Ile Glu His Ala Asp Ile Val Phe 
            20                  25                  30          


Ser Leu Leu Pro Asp Gly Phe Ser Gln Arg Trp Leu Thr Lys Leu Asn 
        35                  40                  45              


Pro Asn Val Ile Asn Leu Gln Gln Phe Tyr Ala Gln Asn Gly Glu Val 
    50                  55                  60                  


Lys Asn Arg Arg Asp Thr Tyr Glu Gln Met Val Asn Ala Ile Leu Asp 
65                  70                  75                  80  


Ala Val Arg Ala Gly Lys Lys Thr Val Cys Ala Leu Tyr Gly His Pro 
                85                  90                  95      


Gly Val Phe Ala Cys Val Ser His Met Ala Ile Thr Arg Ala Lys Ala 
            100                 105                 110         


Glu Gly Phe Ser Ala Lys Met Glu Pro Gly Ile Ser Ala Glu Ala Cys 
        115                 120                 125             


Leu Trp Ala Asp Leu Gly Ile Asp Pro Gly Asn Ser Gly His Gln Ser 
    130                 135                 140                 


Phe Glu Ala Ser Gln Phe Met Phe Phe Asn His Val Pro Asp Pro Thr 
145                 150                 155                 160 


Thr His Leu Leu Leu Trp Gln Ile Ala Ile Ala Gly Glu His Thr Leu 
                165                 170                 175     


Thr Gln Phe His Thr Ser Ser Asp Arg Leu Gln Ile Leu Val Glu Gln 
            180                 185                 190         


Leu Asn Gln Trp Tyr Pro Leu Asp His Glu Val Val Ile Tyr Glu Ala 
        195                 200                 205             


Ala Asn Leu Pro Ile Gln Ala Pro Arg Ile Glu Arg Leu Pro Leu Ala 
    210                 215                 220                 


Asn Leu Pro Gln Ala His Leu Met Pro Ile Ser Thr Leu Leu Ile Pro 
225                 230                 235                 240 


Pro Ala Lys Lys Leu Glu Tyr Asn Tyr Ala Ile Leu Ala Lys Leu Gly 
                245                 250                 255     


Ile Gly Pro Glu Asp Leu Gly 
            260             


<210>  2
<211>  71
<212>  PRT
<213>  Shewanella oneidensis

<400>  2

Met Ser Gly Leu Ser Asp Phe Phe Thr Gln Leu Gly Gln Asp Ala Gln 
1               5                   10                  15      


Leu Met Glu Asp Tyr Lys Gln Asn Pro Glu Ala Val Met Arg Ala His 
            20                  25                  30          


Gly Leu Thr Asp Glu Gln Ile Asn Ala Val Met Thr Gly Asp Met Glu 
        35                  40                  45              


Lys Leu Lys Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val 
    50                  55                  60                  


Ile Ser His Gly Asn Gly Asp 
65                  70      


<210>  3
<211>  262
<212>  PRT
<213>  Streptomyces sp. NRRL S-118

<400>  3

Met Gln Glu Thr Thr Gly Asn Ala Gln Leu Val Val Val Gly Thr Gly 
1               5                   10                  15      


Phe Arg Ala Ile Gly Asp Leu Thr Val Glu Ala Arg Ala Cys Leu Glu 
            20                  25                  30          


Gln Ala Asp Lys Val Leu Cys Leu Ile Gly Asp Pro Leu Val Thr Arg 
        35                  40                  45              


His Ile Glu Lys Leu Asn Ala Ser Val Glu Thr Leu Asp Val His Tyr 
    50                  55                  60                  


Ala Val Gly Lys Pro Arg Ser Ala Ser Tyr Glu Asp Met Val Glu His 
65                  70                  75                  80  


Ile Met Ser Glu Leu His Arg Asp Gln Phe Val Cys Val Ala Leu Tyr 
                85                  90                  95      


Gly His Pro Gly Val Phe Ala Tyr Thr Gly His Glu Ala Ile Arg Arg 
            100                 105                 110         


Ala Arg Glu Glu Gly Ile Ala Ala Arg Met Leu Pro Ala Cys Ser Ala 
        115                 120                 125             


Glu Asp Trp Leu Phe Ala Asp Leu Gly Leu Asp Pro Gly Glu Arg Gly 
    130                 135                 140                 


Cys Gln Ser Phe Glu Ala Thr Asp Phe Leu Ile Arg His Arg Val Phe 
145                 150                 155                 160 


Asp Pro Thr Gly Leu Leu Ile Leu Trp Gln Val Gly Val Ile Gly Met 
                165                 170                 175     


Ile Asp Arg Asp Pro Gly Tyr Asp Ala Arg Pro Gly Val Thr Thr Leu 
            180                 185                 190         


Thr Asp Ala Leu Val Ala Ser Tyr Gly Ser Gly His Pro Val Thr Val 
        195                 200                 205             


Tyr Glu Ala Ser Pro Tyr Val Thr Ala Glu Pro Arg Thr Thr Thr Val 
    210                 215                 220                 


Pro Leu Ala Glu Leu Pro Asp Thr Pro Leu Ser Ala Ala Ser Thr Leu 
225                 230                 235                 240 


Val Val Pro Pro Leu Pro Pro Arg Pro Val Asp Arg Glu Leu Leu Ala 
                245                 250                 255     


Arg Leu Ala Ala Arg Arg 
            260         


<210>  4
<211>  83
<212>  PRT
<213>  Streptomyces sp. NRRL S-118

<400>  4

Met Pro Ala Ala Val Val Asp Phe Met Glu Glu Leu Val Thr Gln Pro 
1               5                   10                  15      


Arg Arg Gln His Ala Tyr Arg Arg Ser Ala Glu Ala Tyr Val Ala Asp 
            20                  25                  30          


Ser Ala Leu Thr Ala Ser Glu Arg Glu Ala Val Val Ser Gly Asp Val 
        35                  40                  45              


Asp Arg Met Arg Ala Val Leu Ala Glu His Ser Gly Val Lys Glu Glu 
    50                  55                  60                  


Cys His Ala Val Leu Val Val Ile Ile Phe Asp Pro Asp Glu Val Pro 
65                  70                  75                  80  


Ser Gly Ala 
            


<210>  5
<211>  409
<212>  PRT
<213>  Rhodospirillum centenum SW

<400>  5

Met Arg Ala Ala Pro Met Ala Glu Thr Glu Thr Pro Pro Ala Ala Pro 
1               5                   10                  15      


Ser Pro Ser Ala Pro Glu Arg Pro Arg Gly Ser Leu Thr Val Val Gly 
            20                  25                  30          


Thr Gly Leu Arg Ala Leu Ser His Met Thr Leu Glu Ala Ile Ser His 
        35                  40                  45              


Ile Arg Asp Ala Asp Arg Val Phe Phe Ser Val Pro Asp Gly Val Thr 
    50                  55                  60                  


Ala Arg Gln Ile Arg Asp Ile Asn Pro Glu Ala Val Asp Leu Thr Gln 
65                  70                  75                  80  


Tyr Tyr Gly Glu Asp Lys Arg Arg Lys Gln Thr Tyr Val Gln Met Ser 
                85                  90                  95      


Glu Val Ile Leu Arg Glu Val Arg Ala Gly Ser Ala Val Thr Ala Val 
            100                 105                 110         


Phe Tyr Gly His Pro Gly Phe Phe Val Phe Pro Ala Arg Arg Ile Leu 
        115                 120                 125             


Ser Ile Ala Arg Lys Glu Gly Tyr Arg Ala Val Met Leu Pro Gly Ile 
    130                 135                 140                 


Ser Ser Leu Asp Cys Leu Met Ala Asp Leu Arg Val Asp Pro Ser Val 
145                 150                 155                 160 


Asn Gly Cys Gln Ile Leu Glu Ala Thr Asp Leu Leu Leu Arg Asn Arg 
                165                 170                 175     


Pro Ile Ile Thr Ser Gly His Val Ile Ile Leu Gln Val Gly Ser Val 
            180                 185                 190         


Gly Asp Ser Ala Phe Ser Phe Thr Ala Gly Phe Arg His Ala Lys Arg 
        195                 200                 205             


Ala Val Leu Phe Glu Arg Leu Ile Glu Ala Tyr Gly Glu Glu His Arg 
    210                 215                 220                 


Ser Val Leu Tyr Leu Ala Ala Thr Tyr Pro Gly Leu Asp Gly Gln Ala 
225                 230                 235                 240 


Val Val Arg Pro Leu Gly Ala Tyr Arg Asp Pro Lys Val Leu Ala Ser 
                245                 250                 255     


Val Pro Pro Ala Gly Thr Leu Tyr Ile Pro Ala Lys Asp Met Leu Pro 
            260                 265                 270         


Thr Asp Met Ala Met Ala Glu Lys Leu Gly Met Ser Ala Leu Val Gly 
        275                 280                 285             


Pro Asp Ala Pro Val Pro Ala Gly Pro Asp Ser Tyr Gly Pro Phe Glu 
    290                 295                 300                 


Ala Gln Ala Ile Ala Ala Leu Asp His Tyr Arg Pro Ser Pro Thr Trp 
305                 310                 315                 320 


Arg Pro Arg Thr Ala Ser Lys Ala Leu Gln Arg Val Met Thr Leu Leu 
                325                 330                 335     


Ala Gly Thr Pro Ser Val Ala Ala Val Tyr Arg Lys Asp Pro Ala Arg 
            340                 345                 350         


Leu Val Asp Leu His Pro Asp Leu Thr Pro Ala Glu Arg Lys Ala Leu 
        355                 360                 365             


Leu Ser Arg Arg Ala Gly Pro Leu Asn Ala Val Thr Ala Pro Pro Pro 
    370                 375                 380                 


Glu Gly Ala Pro Pro Thr Val Asp Glu Ala Gly Asn Gly Asn Gly Gly 
385                 390                 395                 400 


Asp Ala Pro Ser Glu Gly Glu Thr Ala 
                405                 


<210>  6
<211>  125
<212>  PRT
<213>  Rhodospirillum centenum SW

<400>  6

Met Thr Thr Ile Val Pro Thr Glu Leu Asp Gln Pro Asp Val Ile Glu 
1               5                   10                  15      


Leu Ser Gly Gly Glu Leu Asp Val Ala Glu Leu Ser Gly Gly Glu Leu 
            20                  25                  30          


Asp Val Ala Glu Leu Phe Gly Gly Glu Leu Asp Val Ala Glu Leu Ser 
        35                  40                  45              


Gly Gly Glu Leu Asp Val Ala Glu Leu Ser Gly Gly Glu Leu Asp Val 
    50                  55                  60                  


Ala Glu Leu Ser Gly Gly Glu Leu Asp Val Ala Glu Leu Ser Gly Gly 
65                  70                  75                  80  


Glu Leu Asp Val Ala Glu Leu Ser Gly Gly Glu Leu Asp Val Ala Glu 
                85                  90                  95      


Leu Ser Gly Gly Glu Leu Asp Val Ala Glu Leu Ser Gly Gly Glu Leu 
            100                 105                 110         


Asp Val Ala Glu Ile Gly Ile Ile Asn Thr Phe Asp Leu 
        115                 120                 125 


<210>  7
<211>  442
<212>  PRT
<213>  Burkholderia stabilis

<400>  7

Met Ser Glu Ala Lys Gly Arg Leu Val Val Ile Gly Ser Gly Ile Lys 
1               5                   10                  15      


Ala Val Ser His Phe Thr Leu Glu Ala Gln Ala His Ile Gln Gln Ala 
            20                  25                  30          


Asp Ile Val Leu Tyr Ala Ala Ala Asp Pro Val Thr Asp Met Trp Ile 
        35                  40                  45              


Glu Ser Gln Asn Pro Asn Ala Phe Asp Leu Tyr Gln Tyr Tyr Ala Asp 
    50                  55                  60                  


Asp Lys Ala Arg Leu Ile Thr Tyr Val Gln Met Ile Glu Arg Ile Met 
65                  70                  75                  80  


Ala Glu Val Arg Ala Gly Lys Tyr Val Cys Ala Leu Phe Tyr Gly His 
                85                  90                  95      


Pro Gly Val Phe Val Thr Pro Ser His Asn Ala Ile Ala Ile Ala Arg 
            100                 105                 110         


Gln Glu Gly Phe Asp Ala Val Met Leu Pro Ala Val Ser Ala Glu Asp 
        115                 120                 125             


Cys Leu Tyr Ala Asp Leu Gly Val Asp Pro Ser Val Pro Gly Met Gln 
    130                 135                 140                 


Ile Tyr Glu Ala Thr Asp Phe Leu Leu Arg Arg Arg Lys Val Asp Thr 
145                 150                 155                 160 


Thr Ala Asn Phe Val Leu Trp Gln Val Gly Cys Ile Gly Asp Leu Gly 
                165                 170                 175     


Phe Lys Phe Gly Gly Tyr Lys Asn Asp Lys Phe Asp Val Leu Leu Asp 
            180                 185                 190         


Tyr Leu Glu Glu Ile Tyr Gly Ala Asp His Pro Ala Ile Asn Tyr Val 
        195                 200                 205             


Ala Asn Met Phe Ser Gly Pro Pro Gln Ile Asp Arg His Val Ile Gly 
    210                 215                 220                 


Asp Tyr Arg Asp Pro Glu Val Lys Ala Lys Val Ser Gly Ile Ser Thr 
225                 230                 235                 240 


Phe Phe Ile Pro Ala Lys Asp Gly Ile Gln Ser Asp Ala Gly Met Leu 
                245                 250                 255     


Ala Lys Leu Gly Leu Ala Lys Ile Ser Glu Ala Arg Arg Thr Pro Leu 
            260                 265                 270         


Ile Cys Asp Arg Glu Asp Tyr Arg Val Leu Ala Asp Ile Ala Arg Arg 
        275                 280                 285             


Asn Ile His Asn His Lys Val Pro Pro Gly Tyr Lys Tyr Ser Phe Ala 
    290                 295                 300                 


Ser Asp Ala Leu Tyr Gln Thr Leu Leu Thr Leu Ala Leu Asp Gln Arg 
305                 310                 315                 320 


Ala Gln Gly Glu Phe Gln Ala Asn Pro Arg Ala Tyr Leu Glu Ala Arg 
                325                 330                 335     


Pro Gly Leu Thr Ala Asp Glu Arg Arg Ser Leu Leu Leu Gln His Thr 
            340                 345                 350         


Gly Val Thr Arg Met Met Phe Lys Arg Asp Pro Asp Lys Glu Ala Val 
        355                 360                 365             


Arg Phe Val Gly Ala Ala Leu Leu Asp Pro Ala Leu Ala Arg Glu Tyr 
    370                 375                 380                 


Arg Asp Arg Gln Ala Ala Ala Ala Gln Ala Val Ala Asn His Asp Ile 
385                 390                 395                 400 


Pro Val Gly Glu Tyr Glu Gly Val Val Ala Ser Trp Leu Arg Gly Gln 
                405                 410                 415     


Gly Tyr Ala Ala Thr Pro Ala Ala Val Thr Arg Ala Met Glu Glu Val 
            420                 425                 430         


Tyr Thr Ser Lys Asp His Leu Ser Val Ala 
        435                 440         


<210>  8
<211>  308
<212>  PRT
<213>  Burkholderia stabilis

<400>  8

Met Ala Ser Phe Asp Val Ser Gly Thr Tyr Met Thr Ser Trp Leu Gln 
1               5                   10                  15      


Pro Asp Gly Lys Thr Tyr Ile Pro Gly Pro Val Val Ile Asp Thr Ser 
            20                  25                  30          


Asn Gln Ser Val Thr Leu Asn Gly Ala Thr Ile Ala Ser Pro Ser Phe 
        35                  40                  45              


Thr Thr Thr Gly Val Ser Trp Ala Ala Thr Gly Gly Asn Ala Thr Ser 
    50                  55                  60                  


Ala Lys Leu Thr Phe Tyr Gln Asn Gly Gly Val Asn Gly Phe Val Gly 
65                  70                  75                  80  


Leu Phe Ser Gln Gly Ser Asp Pro Leu Pro Ala Ala Asn Asn Leu Phe 
                85                  90                  95      


Gly Asn Ala Gly Ala Ala Thr Gln Gln Leu Ser Thr Trp Asn Gly Thr 
            100                 105                 110         


Tyr Asn Leu Phe Ser Leu Thr Ala Asp Gly Lys Ser Thr Pro Leu Ser 
        115                 120                 125             


Asp Lys Leu Val Ile Ser Ala Pro Gln Val Thr Tyr Gly Gly Ser Ile 
    130                 135                 140                 


Val Asn Lys Pro Val Tyr Thr Gly Glu Lys Gly Pro Lys Gly Glu Ile 
145                 150                 155                 160 


Asp Gln Leu Ala Trp Phe Ser Ala Asn Gly Asn Pro Gln Asn Ala Ile 
                165                 170                 175     


Ile Gln Phe Ser Asn Ser Gln Ala Pro Thr Leu Thr Leu Tyr Gly Glu 
            180                 185                 190         


Leu Trp Asn Ser Gly Ala Gln Pro Thr Tyr Val Asn Leu Ser Gly Thr 
        195                 200                 205             


Thr Lys Ser Ser Ser Thr Pro Pro Thr Ile Thr Val Val Ala Ala Leu 
    210                 215                 220                 


Ile Ser Asn Thr Ala Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val 
225                 230                 235                 240 


Thr Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val 
                245                 250                 255     


Thr Thr Glu Val Leu Thr Glu Val Ala Val Ala Val Val Glu Val Leu 
            260                 265                 270         


Ala Glu Asp Asp Asp Lys Pro Ser Pro Gly Ser Ala Lys Ala Ser Leu 
        275                 280                 285             


Pro Lys Glu Asp Ala Ala Ala Ala Glu Lys Leu Leu Glu Lys Ala Leu 
    290                 295                 300                 


Ala Leu Ala Glu 
305             


<210>  9
<211>  1034
<212>  PRT
<213>  Achromobacter insuavis

<400>  9

Met Glu Leu Ala His Gln Ile Tyr Ala Asp Ile Pro Ser Leu Ser Asp 
1               5                   10                  15      


Thr Ala Ala Arg Glu Pro Ala Thr Ala Thr Gly Glu Leu Thr Ile Ile 
            20                  25                  30          


Gly Ser Gly Ile Gly Val Met Gly Phe Thr Arg Asp Ala Glu Gln Tyr 
        35                  40                  45              


Ile Asp Asp Ala Asp His Val Val Phe Cys Val Ala Asp Pro Ala Thr 
    50                  55                  60                  


Gln Val Trp Leu Arg Gly Arg Arg Pro Asp Ala Ile Asp Leu Phe Ala 
65                  70                  75                  80  


Leu Tyr Asp Asp Arg Lys Pro Arg Tyr His Thr Tyr Met Gln Met Thr 
                85                  90                  95      


Glu Ala Met Leu Tyr His Val Arg Arg Gly Lys Arg Val Ala Ala Val 
            100                 105                 110         


Phe Tyr Gly His Pro Gly Ile Phe Val Leu Ser Thr His Arg Ala Val 
        115                 120                 125             


Ala Ile Ala Arg Arg Glu Gly His Arg Ala Gln Leu Arg Pro Gly Val 
    130                 135                 140                 


Ser Ala Leu Asp Trp Leu Cys Ala Asp Leu Gly Ile Asp Pro Ala Tyr 
145                 150                 155                 160 


Pro Gly Met Gln Thr Phe Glu Ala Thr Asp Met Leu Leu Arg Arg Arg 
                165                 170                 175     


Ala Ile Asp Pro Gly Ser His Val Val Leu Trp Gln Val Gly Leu Ile 
            180                 185                 190         


Ala Glu Met Gly Phe Arg Arg Arg Gly Phe His Asn Arg Arg Phe Asp 
        195                 200                 205             


Tyr Leu Val Glu Tyr Leu Arg Gly Tyr Tyr Lys Pro Asp His Lys Ile 
    210                 215                 220                 


Val His Tyr Ile Ala Ser Arg Tyr Pro Thr Leu Pro Pro Val Ile Glu 
225                 230                 235                 240 


Arg Tyr Thr Leu Asp Glu Leu Gln Asn Pro Glu Val His Ala Leu Ile 
                245                 250                 255     


Thr Gly Ile Ser Thr Phe Tyr Val Pro Pro Ala Gln Ala Arg Ala Val 
            260                 265                 270         


Asp Val Asp Phe Ala Arg Glu Val Gly Leu Ile Gln Pro Gly Gln His 
        275                 280                 285             


Val Gly Lys Pro Arg Leu Ser Arg Pro Leu Asp Arg Tyr Gly Pro Arg 
    290                 295                 300                 


Glu Met Arg Ala Ile Ala Ala Leu Lys Asp Phe Arg Pro Pro Ala Asp 
305                 310                 315                 320 


Tyr His Phe Gln Thr Asp Thr Ala Ala Ala Arg Phe Leu Leu Ala Leu 
                325                 330                 335     


Ser Glu Gln Pro Glu Leu Arg Arg Arg Phe Glu Ala Asn Pro Glu His 
            340                 345                 350         


Ala Leu Ala Ala Phe Pro Gly Leu Ser Ala Glu Glu Arg Lys Gln Leu 
        355                 360                 365             


Ser Ser Arg Arg Thr Ala Arg Thr Gln Arg Ala Ala Arg Gly Ala Ala 
    370                 375                 380                 


Val Ser Ile Ser Pro Gly Glu Gln Phe Val Ile Asp Leu Glu Thr Lys 
385                 390                 395                 400 


Pro Ala Val Ala Asn Gln Trp Met Gln Leu Leu Asn Thr Ala Val Lys 
                405                 410                 415     


Ala Ser Pro Lys Asn Trp Gln Pro Val Glu Asp Trp Leu Ser Gln Asn 
            420                 425                 430         


Tyr Gln Gly Leu Ala Leu Ala Asp Val Ser Asp Ala Val Ser Ser Thr 
        435                 440                 445             


Gln Ala Trp Leu Leu Leu Met Trp Asn Gly Val Tyr Ala Thr Ser Gly 
    450                 455                 460                 


Asn Pro Pro Gln Ala Leu Phe Val Met Ala Gly Ala Pro Gly Asp Gly 
465                 470                 475                 480 


Ala Ala Thr Ser Thr Val Thr Ser Gly Thr Val Tyr Leu Asn Ala Ser 
                485                 490                 495     


Pro Leu Phe Lys Ile Ser Phe Ser Gly Gly Gln Leu Thr Phe Ser Gln 
            500                 505                 510         


Lys Asp Gly Asn Pro Cys Asn Gly Thr Leu Thr Phe Ala Asn Pro Gly 
        515                 520                 525             


Ala Ser Thr Pro Gln Ser Val Ser Gly Met Leu Trp Gln Asp Ser Gln 
    530                 535                 540                 


Gly Lys Pro Ser Ser Asn Asn Phe Thr Ala Thr Leu Gln Pro Leu Pro 
545                 550                 555                 560 


Ser Asn Pro Leu Ser Val Trp Thr Gly Glu Tyr Ala Thr Val Tyr Thr 
                565                 570                 575     


Asp Asn Gln Gln Ala Gly Pro Gly Val Ala Val Phe Leu Pro Ser Thr 
            580                 585                 590         


Thr Asn Pro Ser Pro Thr Leu Tyr Ile Gly Gly Gln Glu Val Ser Gly 
        595                 600                 605             


Thr Ser Phe Ala Asn Pro Thr Ile Thr Trp Ser Gly Gly Gln Leu Ser 
    610                 615                 620                 


Phe Ala Leu Asp Ala Ser Thr Thr Gly Ala Leu Thr Leu Ser Gly Asn 
625                 630                 635                 640 


Ile Ala Gly Arg Ala Ile Thr Gly Asn Thr Val Ala Ser Ser Ala Thr 
                645                 650                 655     


Gly Phe Ala Gly Gln Tyr Ala Thr Gln His Val Ala Ser Val Lys Gly 
            660                 665                 670         


Ala Asn Val Trp Gln Pro Phe Tyr Pro Leu Gly Phe Thr Ala Pro Thr 
        675                 680                 685             


Ser Gly Ser Thr Thr Cys Thr Ala Trp Leu Gly Ser Gln Ser Phe Thr 
    690                 695                 700                 


Ala Gln Phe Ser Asn Arg Gln Leu Thr Trp Ser Asn Gly Pro Ser Gln 
705                 710                 715                 720 


Ile Pro Asn Gly Gln Leu Ser Leu Ser Val Asn Ala Leu Thr Asn Ala 
                725                 730                 735     


Ala Cys Phe Val Gly Val Thr Trp Ala Asn Gly Asp Ala Lys Pro Thr 
            740                 745                 750         


Ser Pro Asn Ile Gln Gly Ile Ala Ser Ala Asn Ser Pro Ala Asn Phe 
        755                 760                 765             


Val Gly Asn Tyr Asn Thr Thr Leu Asp Gln Gln Pro Ala Gln Val Leu 
    770                 775                 780                 


Ser Ile Gly Gly Asp Pro Asn Ser Ile Gln Val Thr Tyr Gly Ser Glu 
785                 790                 795                 800 


Lys Val Thr Tyr Ser Phe Phe Thr Gly Gln Leu Ser Gly Thr Thr Ser 
                805                 810                 815     


Ser Gly Leu Lys Leu Asn Ala Val Phe Lys Tyr Val Thr Gln Gly Ser 
            820                 825                 830         


His Thr Pro Ala Gln Tyr Val Thr Ala Phe Thr Gly Thr Gln Thr Val 
        835                 840                 845             


Asn Ser Ala Gln His Gln Trp Asp Ser Ser Gln Leu Ser Asn Asp Val 
    850                 855                 860                 


Gln Gln Trp Leu Gly Thr Tyr Thr Thr Phe Leu Val Asp Pro Gly Asn 
865                 870                 875                 880 


Gly Ser Leu Thr Ala Gly Gly Pro Thr Leu Thr Leu Ser Gly Thr Ala 
                885                 890                 895     


Ala Ser Phe Thr Val Gln Ile Thr Ala Asp Gly Thr Thr Thr Thr Leu 
            900                 905                 910         


Gln Asn Pro Lys Tyr Gln Ile Thr Gly Asn Thr Leu Tyr Trp Ser Gly 
        915                 920                 925             


Glu Asn Val Ser Gly Gly Ser Asn Tyr Asn Asn Gly Ala Ile Ser Phe 
    930                 935                 940                 


Tyr Leu Asp Pro Arg Lys Gln Gln Arg Ala Phe Lys Gly Val Phe Tyr 
945                 950                 955                 960 


Ala Asn Lys Pro Ala Pro Asn Ala Ile Asn Trp Tyr Gly Thr Pro Ala 
                965                 970                 975     


Gly Asn Asn Pro Ser Pro Pro Ser Pro Gly Phe Pro Trp Trp Gly Tyr 
            980                 985                 990         


Leu Leu Ile Gly Leu Gly Ile Val  Gly Leu Gly Val Gly  Gly Leu Leu 
        995                 1000                 1005             


Leu Trp  Arg Ala Arg Ala Ser  Gly Tyr Gln Arg Leu  Ala Thr Glu 
    1010                 1015                 1020             


Asp Ser  Ile Glu Met Trp Glu  Lys Lys Cys Gln 
    1025                 1030                 


<210>  10
<211>  111
<212>  PRT
<213>  Achromobacter insuavis

<400>  10

Met Ala Asn Thr Arg Leu Leu Glu Gly Gly Thr Cys Gln Asp Leu Glu 
1               5                   10                  15      


Asp Asp Phe Asp Glu Gln Ser Glu Glu Phe Asp Asn Ala Ser Asp Asp 
            20                  25                  30          


Ala Ser Leu Asn Asn Pro Glu Glu Leu Asp Ile Gly Asp Asp Val Glu 
        35                  40                  45              


Ile Pro Asp Asp Pro Asn Val Asp Val Asp Val Asp Ala Asp Val Glu 
    50                  55                  60                  


Ala Asp Ile Glu Thr Glu Val Asp Val Asp Val Asp Val Asp Val Thr 
65                  70                  75                  80  


Leu Glu Met Phe Leu Glu Glu Asp Leu Glu Arg Ser Glu Pro Gly Ile 
                85                  90                  95      


Asp Phe Val Thr Gly Ala Asp Gly Leu Asp Gly Asp Glu Arg Pro 
            100                 105                 110     


<210>  11
<211>  806
<212>  PRT
<213>  Pseudomonas mosselii

<400>  11

Met Ser Met Thr Thr Arg Asn Asn Arg Glu His Ala Gln Ala Thr His 
1               5                   10                  15      


Tyr Pro Ser Ala Glu Glu His Arg Arg Arg Trp Arg Arg Leu Ala Gln 
            20                  25                  30          


Ala Ile Ala Ala Arg Ala Ala Ser Ile Ser Asp Asp Pro Ala Leu Leu 
        35                  40                  45              


Val Ala Pro Gln Arg Pro Gly Thr Leu Glu Ile Leu Gly Ser Gly Ile 
    50                  55                  60                  


Glu Ala Ser Asp Phe Ser Arg Ser Asp Glu Ala Arg Ile Leu Val Ala 
65                  70                  75                  80  


Asp His Val Phe Tyr Cys Val Ala Asp Pro Ala Thr Lys Ile Trp Ile 
                85                  90                  95      


Leu Ser Gln Arg Pro Asp Ala Tyr Asp Leu Tyr Val Leu Tyr Asp Asp 
            100                 105                 110         


Ser Lys Pro Arg Tyr Leu Thr Tyr Met Gln Met Thr Glu Ala Met Leu 
        115                 120                 125             


His His Val Arg Asn Gly Glu His Val Val Ala Ile Phe Tyr Gly His 
    130                 135                 140                 


Pro Gly Val Phe Val Leu Ser Thr His Arg Ala Val Thr Ile Ala Arg 
145                 150                 155                 160 


Arg Glu Gly His His Ala Ser Met Arg Ala Ala Val Ser Ala Leu Asp 
                165                 170                 175     


Thr Leu Cys Ala Asp Leu Gly Val Asp Pro Ser Gln Pro Gly Met Gln 
            180                 185                 190         


Met Tyr Glu Ala Thr Asp Met Leu Ile Arg Arg Arg Gln Pro Asp Pro 
        195                 200                 205             


Gly Leu His Leu Val Leu Trp Gln Val Gly Leu Ile Gly Glu Leu Gly 
    210                 215                 220                 


Tyr Arg Arg Gln Gly Tyr Leu Asn Ser Asn Phe Ala Val Leu Leu Asp 
225                 230                 235                 240 


Tyr Leu Glu Asp Leu Tyr Gly Pro Glu His Pro Val Ile Asn Tyr Val 
                245                 250                 255     


Gly Ser Arg Tyr Pro Gly Ile Asp Pro Leu Ile Asp Arg Gln Thr Leu 
            260                 265                 270         


Ala Ser Leu Arg Asp Pro Leu Ala Gln Ser Trp Val Thr Gly Ile Ser 
        275                 280                 285             


Thr Phe Tyr Leu Pro Pro Arg Thr Ala Gly Gln Ser Asp Pro Gln Met 
    290                 295                 300                 


Leu Glu Arg Leu Gly Leu Ile Arg Pro Gly Gln Pro Val Arg Ala Ala 
305                 310                 315                 320 


Ser Asp Pro Leu Arg Val Ile Asp Arg Tyr Asp Lys Arg Glu Arg Arg 
                325                 330                 335     


Ala Phe Ser Asp Phe Ala Arg Phe Asp Val Pro Ala Ser Tyr Gln Trp 
            340                 345                 350         


Gln Ala Asp Thr Gly Ala Gly Arg Phe Ile Leu Ala Leu Ser Asp Asp 
        355                 360                 365             


Ala Glu Leu Arg Arg Gln Tyr Arg Asp Asp Pro Gln Ala Ala Val Gln 
    370                 375                 380                 


Ala Trp Gly Gly Leu Asp Ala Arg Glu Arg His Leu Leu Gly Gln Arg 
385                 390                 395                 400 


Asp Pro Gly Ala Val Gln Leu Ala Ala Lys Gly Ala Asp Ala Gln Arg 
                405                 410                 415     


His Pro Gly Asn Arg Glu Gly Val Glu His Leu Leu Thr Tyr Thr Ser 
            420                 425                 430         


Ala Ser Ser Ala Leu His Arg Ala Leu Ser Ala Ala Ala Pro Gly Glu 
        435                 440                 445             


Leu Arg Ala Ala Ala Ala Ala Trp Ser Arg Lys Ala Gly Leu Ser Ile 
    450                 455                 460                 


Asp Trp Pro Gly Met Asn Ala Glu Leu Asn Ala Leu Leu Gln Ser Ser 
465                 470                 475                 480 


Leu Ala Pro Trp Ser Gly Phe Tyr Leu Asp Ser Ser Arg Arg Met Ser 
                485                 490                 495     


Leu Ser Leu Phe Ser Arg Met Lys Asn Ala Gly Leu Arg Val Asp Leu 
            500                 505                 510         


Asp Gly Gln Pro Leu Val Gly Val Arg Tyr Gln Ser Gly Val Leu Thr 
        515                 520                 525             


Trp Ser Ala Glu Ala Gly Asn Gly Ser Ser Gly Tyr Leu Gln Ser Asp 
    530                 535                 540                 


Leu Ser Val Gln Gly Gly Arg Ser Trp Ile Gly Leu Val Trp Pro Ala 
545                 550                 555                 560 


Gly Glu Gln Ala Gly Ser Gly Tyr Lys Val Ala Leu Arg Gly Gln Ser 
                565                 570                 575     


Leu Ala Arg Pro Ala Cys Leu Ala Val Gly Asp Tyr Arg Val Ala Gly 
            580                 585                 590         


Glu Ala Leu Arg Ile Val Pro Ser Ala Ser Ala Ser Gln Gly Val Asp 
        595                 600                 605             


Val Leu Arg Glu Gly Val Ala Leu Pro Gly Glu Val Leu Phe Asn Gly 
    610                 615                 620                 


Arg Asp Thr Arg Ile Gly Asp Arg Arg Leu Ala Leu Ser Thr Arg Arg 
625                 630                 635                 640 


Phe Glu Asp Leu Ala Gln Trp Ala Gln Gly Ala Tyr Arg Leu Arg Leu 
                645                 650                 655     


Val His Gly Arg Leu Ala Glu Leu Leu Ala Leu Arg Leu Gly Pro Tyr 
            660                 665                 670         


Gly Leu Glu Ile Ala Gly Lys Pro Val Thr Ala Glu Phe Arg Glu Gly 
        675                 680                 685             


Arg Ile Gln Trp Gln Gly Gly Pro Pro Ala Val Glu Ser Gly Gln Leu 
    690                 695                 700                 


Asp Val Thr Leu Asp Pro Ile Thr Leu Lys Pro Leu Leu His Gly Gln 
705                 710                 715                 720 


Gly Arg Ser Ala Ala Gly Asn Lys Val Gln Leu Arg Gly Met Ala Leu 
                725                 730                 735     


Ile Glu Pro Leu Trp Ile Asp Gln Leu Leu Glu Gln Pro Arg Leu Gly 
            740                 745                 750         


Leu Pro Glu Trp Ala Trp Arg His Leu Val Ala Val Met Val Ala Ala 
        755                 760                 765             


Ser Asp Lys Gly Gly Ile Phe Leu Trp His Gly Tyr Asp Arg Ala Arg 
    770                 775                 780                 


Gly Asn Leu Arg Leu Leu Arg Glu Ala Leu Ala Arg Leu Arg Gln Asp 
785                 790                 795                 800 


Glu Met Glu Asp Ala Gly 
                805     


<210>  12
<211>  605
<212>  PRT
<213>  Pseudomonas mosselii

<400>  12

Met Ala Thr Tyr Pro Val Gln Ile Thr Asn Asn Thr Asn Leu Ala Leu 
1               5                   10                  15      


Asp Ile Tyr Thr Thr Leu Asn Lys Asn Pro Ala Thr Asp Pro Pro Ser 
            20                  25                  30          


Thr Asn Pro Ala Asp Tyr Thr Ala Val Tyr Thr Leu Gln Gly Ser Val 
        35                  40                  45              


Gly Ala Asn Gln Ser Thr Thr Leu Pro Leu Thr Glu Ser Leu Ala Arg 
    50                  55                  60                  


Leu Val Ile Val Arg Gln Ser Asp Gln Phe Pro Leu Leu Val Gln Val 
65                  70                  75                  80  


Ala Asn Ala Leu Leu Pro Asp Ser Glu Gln Val Gln Val Gly Asn Gln 
                85                  90                  95      


Asp Val Thr Thr Ala Asn Ser Gly Trp Ala Phe Tyr Gln Ser Phe Ile 
            100                 105                 110         


Ser Gln Pro Phe Thr Pro Thr Ala Leu Glu Phe Ser Glu Leu Val Ser 
        115                 120                 125             


Glu Thr Pro Ala Asn Ala Leu Asn Asp Lys Ala Ala Ser Phe Phe Ala 
    130                 135                 140                 


Ala Asn Gly Tyr Pro Gly Val Ser Phe Ala Leu Phe Ser Ala Leu Gly 
145                 150                 155                 160 


Tyr Trp Ala Asn Asn Gln Leu Tyr Ala Tyr Pro Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Tyr Glu Pro Pro Ser Gly Asn Ser Met Gly Phe Ile Leu Pro Thr Thr 
            180                 185                 190         


Ser Val Gly Thr Leu Thr Ile Ala Gly Gly Lys Ala Asn Tyr Ser Pro 
        195                 200                 205             


Ser Thr Gly Gly Ser Thr Ala Leu Gln Phe Gln Tyr Gly Gln Leu Thr 
    210                 215                 220                 


Ser Pro Gly Ala Asp Asp Lys His Gly Phe Asn Thr Thr Gly Phe Ile 
225                 230                 235                 240 


Arg Asp Leu Thr Trp Glu Gly Lys Pro Asp Val Ile Thr Trp Ala Phe 
                245                 250                 255     


Val Gly Thr Tyr Asp Gly Gln Gln Phe Ile Ala Gln Ser Tyr Gln Ser 
            260                 265                 270         


Pro Gln Leu Pro Trp Tyr Ala Val Ala Tyr Asp Met Ala Tyr Gly Ala 
        275                 280                 285             


Leu Phe Thr Val Gln Leu Ala Met Thr Leu Asp Ala Ala Ile Asn Leu 
    290                 295                 300                 


Leu Gly Thr Val Ala Asn Gly Met Gln Trp Leu Ala Gln Asn Thr Gly 
305                 310                 315                 320 


Lys Leu Ile Ser Arg Ile Gln Asp Ser Leu Asn Ser Thr Gly Asp Thr 
                325                 330                 335     


Ala Gly Ala Gly Ser Gly Val Gly Asp Ala Ala Asp Pro Val Asn Val 
            340                 345                 350         


Asp Val Asp Ile Asp Val Asp Ile Asp Val Asp Val Asp Val Asp Ile 
        355                 360                 365             


Asp Ile Asp Ile Asp Val Asp Val Asp Val Asp Ile Asp Ile Asp Val 
    370                 375                 380                 


Asp Val Asp Phe Ile Ala Val Val Asp Val Asp Val Asp Val Asp Ile 
385                 390                 395                 400 


Asp Val Asp Ile Asp Val Val Thr Asp Thr Glu Thr Asp Ile Asp Ile 
                405                 410                 415     


Asp Val Asp Val Asp Ile Asp Thr Asp Val Asn Val Glu Pro Gly Ala 
            420                 425                 430         


Leu Met Lys Val Val Asn Gly Val Gly Asn Trp Ile Met Thr Lys Ala 
        435                 440                 445             


Leu Pro Thr Leu Ile Glu Gly Ala Val Ile Tyr Val Ala Phe Gln Ser 
    450                 455                 460                 


Val Gly Ala Ile Phe Gln Ala Trp Lys Asn Gln Asp Glu Lys Asp Ile 
465                 470                 475                 480 


Glu Asn Leu Gln Pro Arg Gln Ser Thr Gly Val Gly Val Leu Val Asn 
                485                 490                 495     


Tyr Met Leu Gln Asp Asp Lys Pro Val Ala Ala Arg Trp Gln Thr Phe 
            500                 505                 510         


Ser Gln Tyr Val Ala Glu Val Gln Gly Asp Pro Lys Thr Val Gly Val 
        515                 520                 525             


Thr Ile Ser Thr Leu Leu Gln Thr Gly Asn Thr Lys Ala Asp Asn Asp 
    530                 535                 540                 


Ala Ala Asn Trp Arg Trp Ser Ser Asp Asp Glu Asn Gln Val Val Ala 
545                 550                 555                 560 


Ser Met Ala Pro Tyr Thr Gly Asp Gln Ala Cys Lys Ala Phe Val Ile 
                565                 570                 575     


Leu Gly Asn Ala Thr Tyr Gln Gly Lys Pro Leu Pro Val Lys Val Gly 
            580                 585                 590         


Ala Ser Val Ala Met Lys Tyr Leu Ala Ala Gln Gly Ala 
        595                 600                 605 


<210>  13
<211>  372
<212>  PRT
<213>  Brevibacillus laterosporus PE36

<400>  13

Met Lys Lys Gly Ser Leu Ile Val Val Gly Ser Gly Ile Lys Gly Val 
1               5                   10                  15      


Ala His Phe Thr Val Glu Ala Gln Gly Trp Ile Arg Glu Ala Asp Val 
            20                  25                  30          


Val Pro Tyr Cys Val Ser Asp Pro Val Ser Glu Val Trp Ile Lys Glu 
        35                  40                  45              


Asn Ser Lys His Ser Ile Asp Leu Tyr Gln Phe Tyr Gly Asn Glu Lys 
    50                  55                  60                  


Gln Arg Ile Asn Thr Tyr Asn Glu Met Val Asp Glu Ile Leu Ser His 
65                  70                  75                  80  


Val Arg Ser Gly Lys Asp Thr Cys Ala Val Phe Tyr Gly His Pro Gly 
                85                  90                  95      


Ile Phe Val His Pro Ser His Lys Ala Ile Ser Ile Ala Arg Ser Glu 
            100                 105                 110         


Gly Tyr Lys Ala Ala Met Leu Pro Gly Ile Ser Ala Leu Asp Cys Leu 
        115                 120                 125             


Cys Ala Asp Leu Gly Val Asp Pro Ser Val Thr Gly Met Gln Thr Val 
    130                 135                 140                 


Glu Ala Thr Asp Leu Leu Leu Arg Asn Arg Arg Leu Asn Thr Asp Gln 
145                 150                 155                 160 


Asn Val Val Ile Trp Gln Ile Gly Cys Val Gly Asp Leu Gly Phe Asn 
                165                 170                 175     


Phe Ser Gly Tyr Asp Asn Arg Asn Leu Lys Ile Leu Val Glu Tyr Leu 
            180                 185                 190         


Glu Lys Phe Tyr Ala Lys Asp His Met Val Thr His Tyr Gln Gly Ser 
        195                 200                 205             


Gln Tyr Ser Ile Cys Pro Pro Ser Ile Ala Lys Met Pro Leu Ser Glu 
    210                 215                 220                 


Leu Lys Asn Ala Pro Val Thr Gly Ile Ser Thr Leu Tyr Ile Pro Pro 
225                 230                 235                 240 


Gln Asp Lys Leu Lys Leu Asp Glu Glu Met Val Gln Arg Leu Gly Leu 
                245                 250                 255     


Arg Lys Thr Gln Thr Val Asn Thr Gln Lys Val Ala Glu Pro Ala Arg 
            260                 265                 270         


Lys Thr Asp Gln Gln Lys Val Gln Pro Arg Lys Ala Ser Tyr Asn Gln 
        275                 280                 285             


Tyr Val Ala Ala Pro Asp His Ser Glu Leu Ala Asn Phe Leu Ala Glu 
    290                 295                 300                 


Leu Ser Glu Ser Pro Leu Leu Leu Ala Gln Phe Met Arg Asn Pro Glu 
305                 310                 315                 320 


Ile Thr Ser Ser Leu Met Ala Asp Leu Ser Pro Ser Glu Lys Asp Ala 
                325                 330                 335     


Leu Leu Ser Gln His Pro Gly Lys Ile Arg Met Ala Ile Lys Leu Ser 
            340                 345                 350         


Ser Trp Asn Lys His Leu Lys Gly Val Ser Thr Leu Ile Lys Gln Arg 
        355                 360                 365             


Glu Asn Asn Phe 
    370         


<210>  14
<211>  590
<212>  PRT
<213>  Brevibacillus laterosporus PE36

<400>  14

Met Asn Lys Arg Thr Glu Asn Asn Ile Glu Ser Tyr Asp Asp Ala Gln 
1               5                   10                  15      


Lys Phe Phe Gln Gln Leu Leu Ile Asn Pro Gln Leu Ala Lys Glu Tyr 
            20                  25                  30          


Val Glu Pro Ile Gln Gln Ala Gln Ile Asn Glu Asn Pro Asp Val Ile 
        35                  40                  45              


Thr Thr Trp Leu Ala Ser Lys Gly Tyr Asn Thr Asn Pro Asp Glu Ile 
    50                  55                  60                  


Thr Gln Ala Gln Glu Gln Met Gln Asn Thr Asp Leu Ile Tyr Trp Ala 
65                  70                  75                  80  


Gly Ile Tyr Gly Arg Thr Ser Val Ser Ser Asp Ile Pro Pro Asn Lys 
                85                  90                  95      


Asn Ser Val Phe Lys Pro Gly Pro Pro Leu Val Val Gln Asp Asp Lys 
            100                 105                 110         


Thr Val Val Leu Asn Ser Ile Pro Leu Lys Asn Phe Thr Phe Lys Asn 
        115                 120                 125             


Lys Thr Leu Thr Trp Gly Phe Ser Asp Asn Ser Thr Ala Gly Ser Ile 
    130                 135                 140                 


Thr Phe Val Glu Val Pro Ser Val Asn Ser Asp Ser Thr Ala Pro Gln 
145                 150                 155                 160 


Ser Tyr Thr Gly Lys Glu Phe Thr Gly Thr Ile Gln Met Ser Ser Gly 
                165                 170                 175     


Glu Glu Lys Glu Phe Tyr Ser Gly Gln Ile Gly Pro Ile Thr Ala Phe 
            180                 185                 190         


Pro Leu Ala Asn Trp Ser Gly Tyr Tyr Gly Glu Thr Ser Ile Glu Gln 
        195                 200                 205             


Ser Ala Asn Asn Tyr Ile Ala Gly Pro Thr Leu Ile Val Arg Asp Asn 
    210                 215                 220                 


Glu Thr Val Leu Leu Asn Asn Gln Pro Leu Val Asn Phe Thr Tyr Asp 
225                 230                 235                 240 


Asn Ile Lys Asn Gln Leu Thr Trp Ser Gln Gln Asp Asn Asp Ser Ser 
                245                 250                 255     


Gly Ser Ile Tyr Phe Ala Arg Thr Thr Thr Pro Thr Gln Thr Gly Tyr 
            260                 265                 270         


Val Gly Leu Tyr Phe His Gly Thr Ile Lys Gln Ser Ser Asp Gln Ser 
        275                 280                 285             


Leu Pro Tyr Thr Gly His Ile Ser Thr Pro Lys Lys Leu Glu Asp Trp 
    290                 295                 300                 


Thr Gly Val Tyr Gly Gln Thr Val Leu Thr Asp Ser Asp Asn Lys His 
305                 310                 315                 320 


Ser Gln Gly Pro Glu Leu Lys Val Ile Ser Asn Thr Arg Val Thr Leu 
                325                 330                 335     


Asp Gly Val Asp Leu Lys Asn Phe Ser Tyr Asp Glu Asn Gln Lys Leu 
            340                 345                 350         


Leu Thr Trp Ser Ile Ala Asp Asn Ser Thr Ala Gly Asn Ile Thr Phe 
        355                 360                 365             


Gly Lys Ile Thr Thr Pro Thr Ser Gln Gly Tyr Val Gly Asn Tyr Phe 
    370                 375                 380                 


Glu Gly Thr Leu Gln Gln Ser Lys Ala Ser Glu Pro Leu Lys Tyr Phe 
385                 390                 395                 400 


Gly Glu Val Gly Thr Ala Ser Ser Tyr Ser Gly Gly Tyr Gln Pro Ser 
                405                 410                 415     


Thr Val Glu Lys Val Phe Gln Ile Leu Gly Tyr Val Ala Thr Val Ala 
            420                 425                 430         


Gly Leu Ala Gln Met Val Tyr Val Gly Tyr Lys Val Gly Lys Trp Ala 
        435                 440                 445             


Trp Glu Lys Leu Phe Lys Ser Gln Ser Glu Thr Ser Glu Ile Thr Asp 
    450                 455                 460                 


Gly Leu Ala Glu Gly Val Glu Pro Glu Leu Val Arg Tyr Thr Pro Ile 
465                 470                 475                 480 


Asp Pro Glu Asn Pro Pro Pro Ile Asn Thr Thr Ser Glu Thr Thr Thr 
                485                 490                 495     


Glu Thr Val Ala Glu Pro Val Thr Thr Thr Glu Thr Glu Val Val Thr 
            500                 505                 510         


Ser Glu Val Thr Ser Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr 
        515                 520                 525             


Thr Glu Val Thr Thr Glu Val Val Glu Val Val Glu Val Val Glu Val 
    530                 535                 540                 


Val Glu Val Val Glu Val Val Glu Val Val Glu Val Val Glu Val Val 
545                 550                 555                 560 


Glu Val Val Glu Val Val Glu Val Val Phe Ala Glu Asp Glu Glu Lys 
                565                 570                 575     


Asp Glu Glu Lys Asp Glu Asp Glu Asp Val Lys Lys Glu Asp 
            580                 585                 590 


<210>  15
<211>  535
<212>  PRT
<213>  Spirosoma linguale DSM74

<400>  15

Met Asn Lys Asn Gly Lys Leu Ile Val Ile Gly Ser Gly Ile Lys Ser 
1               5                   10                  15      


Ile Ala His Phe Thr Leu Glu Ser Gln Ala His Leu Gln Gln Ala Asp 
            20                  25                  30          


Ile Val Leu Tyr Ala Ala Ser Asp Pro Val Thr Asp Met Trp Ile Gln 
        35                  40                  45              


Lys Gln Asn Pro Asn Ser Phe Asp Leu Tyr Gln Tyr Tyr Gly Asn Thr 
    50                  55                  60                  


Lys Asn Arg Ile Ile Thr Tyr Thr Gln Met Ile Glu Arg Val Met Met 
65                  70                  75                  80  


Glu Leu Arg Ser Gly Lys Tyr Val Cys Ala Leu Phe Tyr Gly His Pro 
                85                  90                  95      


Gly Val Phe Val Thr Pro Ser His Asn Ala Ile Glu Leu Ala Arg Arg 
            100                 105                 110         


Glu Gly Tyr Glu Ala Glu Met Leu Pro Gly Ile Ser Ala Glu Asp Cys 
        115                 120                 125             


Leu Phe Ala Asp Leu Gly Val Asp Pro Ser Ile Pro Gly Leu Gln Thr 
    130                 135                 140                 


Tyr Glu Ala Thr Asp Leu Leu Leu Arg Gln Arg Ser Ile Asn Thr Glu 
145                 150                 155                 160 


Ile Asn Ala Val Ile Trp Gln Val Gly Cys Val Gly Asp Val Gly Phe 
                165                 170                 175     


Lys Phe His Gly Tyr Asp Asn Glu Lys Leu Asn Ile Leu Leu Asp Tyr 
            180                 185                 190         


Leu Asp Lys Phe Tyr Pro Pro Asp Gln Ile Val Tyr Asn Tyr Val Ala 
        195                 200                 205             


Ser Met Phe Ser Met Ala Lys Pro Lys Lys Asp Lys Phe Lys Leu Ser 
    210                 215                 220                 


Asp Phe Arg Asp Pro Ser Ile Ala Lys Glu Val Thr Gly Ile Ser Thr 
225                 230                 235                 240 


Phe Phe Ile Pro Ala Val Thr Met Thr Glu Ser Asp Ile Glu Met Ser 
                245                 250                 255     


Lys Lys Leu Gly Leu Lys Ser Gly Lys Ser Arg Ser Asn Pro Leu Ile 
            260                 265                 270         


Cys Asp His Glu Leu Tyr Pro Ser Tyr Lys Lys Val Ala Leu Lys Asn 
        275                 280                 285             


Ile Ser Glu His Leu Ile Pro Glu Gly Tyr Lys Phe Ser His Ser Ser 
    290                 295                 300                 


Asp Ala Leu Tyr Asn Leu Val Thr Arg Leu Ala Leu Asp Phe Lys Glu 
305                 310                 315                 320 


Leu Tyr Lys Tyr Arg Glu Asn Pro Ser Ala Tyr Leu Lys Leu Ile Pro 
                325                 330                 335     


Glu Leu Thr Pro Thr Glu Arg Asn Met Leu Thr Met Gln His His Gly 
            340                 345                 350         


Ala Leu Arg Met Leu Phe Lys Arg Asp Arg Met Glu Glu Ala Arg Leu 
        355                 360                 365             


Phe Val Asp Glu Ala Ile Lys Lys Pro Thr Ile Ala Asn Glu Tyr Leu 
    370                 375                 380                 


Lys Lys Gln Gln Ala Glu Tyr Asp Ala Leu Ile Asn Glu Glu Ile Ser 
385                 390                 395                 400 


Glu Ser Asp Tyr Glu Ala Arg Leu Val Lys Trp Phe Leu Asp Lys Gly 
                405                 410                 415     


Tyr Ala Thr Thr Pro Ser Ala Val Thr Ala Ser Ile Asn Val Leu Glu 
            420                 425                 430         


Met Pro Asp Ile Ile Asp Phe Ser Gly Glu Tyr Gln Cys Val Leu Thr 
        435                 440                 445             


Met Asn Asp Ser Lys Gln Lys Val Ser Val Lys Val Asn Ile Leu Asp 
    450                 455                 460                 


Gln Thr Ile Ala Val Asn Asn Glu Leu Ile Glu Thr Pro Tyr Phe Gly 
465                 470                 475                 480 


Gly Asp His Val Ile Trp Ser Lys Glu Asp Lys Asn Asn Ser Thr Gly 
                485                 490                 495     


Val Leu Thr Phe Ser Lys Gln Leu Asn Ala Phe Ile Leu Glu Gly Lys 
            500                 505                 510         


Tyr Ala Asn Asn Ser Ser Val Leu Pro Glu Thr Tyr Asn Leu His Gly 
        515                 520                 525             


Val Thr Asp Thr Ala Tyr Asn 
    530                 535 


<210>  16
<211>  299
<212>  PRT
<213>  Spirosoma linguale DSM74

<400>  16

Met Thr Ala Thr Asn Phe Ser Gly Asn Tyr Met Ser Phe Val Leu Gly 
1               5                   10                  15      


Val Asp Gly Asn Thr Trp Gly Pro Gly Pro Val Val Ala Val Asn Thr 
            20                  25                  30          


Thr Ser Gln Thr Leu Phe Ile Asp Gly Val Gln Val Asn Asn Pro Thr 
        35                  40                  45              


Phe Thr Ser Thr Ser Val Met Trp Met Ala Ser Ser Asn Asn Pro Ser 
    50                  55                  60                  


Ser Gly Ser Ile Lys Phe Tyr Ser Ser Ala Pro Asp Thr Gly Gly Phe 
65                  70                  75                  80  


Ile Gly Thr Tyr Val Glu Gly Thr Ala Pro Leu Pro Ser Ser Asn Asn 
                85                  90                  95      


Phe Ser Gly Val Ser Ser Ala Ala Pro Asp Asp Leu Ser Val Trp Asn 
            100                 105                 110         


Gly Thr Tyr Asn Thr Phe Ile Leu Asn Gly Ser Lys Trp Thr Gln Asp 
        115                 120                 125             


Ser Thr Leu Ile Val Ala Ala Pro Asn Ile Ser Tyr Asn Gly Lys Asp 
    130                 135                 140                 


Ile Ser Asn Tyr Ile Tyr Met Gly Thr Lys Ser Thr Gln Asn Leu Asp 
145                 150                 155                 160 


Gln Leu Ser Trp Phe Val Ala Gly Gly Asn Ala Gln Asn Ala Ile Val 
                165                 170                 175     


Glu Phe Phe Lys Asp Ser Ser Gly Tyr Leu Thr Phe Gly Gly Thr Gln 
            180                 185                 190         


Trp Val Ser Gly Asp Ala Pro Ala Ala Asn Asn Phe Ile Gly Thr Thr 
        195                 200                 205             


Lys Ala Thr Pro Glu Pro Pro Thr Ile Thr Ala Val Val Ala Ile Val 
    210                 215                 220                 


Ile Asn Ser Ser Thr Thr Glu Val Ala Glu Val Thr Glu Val Thr Glu 
225                 230                 235                 240 


Val Thr Glu Val Thr Glu Val Thr Glu Val Val Glu Val Val Glu Val 
                245                 250                 255     


Val Glu Val Val Glu Val Ile Ala Ala Ala Glu Glu Ala Glu Val Lys 
            260                 265                 270         


Gly Gln Gln Gln Gln Ser Lys Ile Ser Thr Ala Gln Gln Asp Gln Glu 
        275                 280                 285             


Ala Ala Tyr Lys Leu Ser Arg Lys Ser Asn Gly 
    290                 295                 


<210>  17
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - wild-type SonA with N-terminal His-tag

<400>  17

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  18
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Extcore SonA mutant with N-terminal His-tag

<400>  18

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Ile Val Leu Val Ile Ser His Gly Asn 
65                  70                  75                  80  


Gly Asp 
        


<210>  19
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KTLext SonA mutant with N-terminal His-tag

<400>  19

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Lys Thr Leu Ser 
    50                  55                  60                  


Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly 
65                  70                  75                  80  


Asp 
    


<210>  20
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KTLdel SonA mutant with N-terminal His-tag

<400>  20

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Ser Gly Asp Ser Ser Tyr Gln 
    50                  55                  60                  


Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75  


<210>  21
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63G SonA mutant with N-terminal His-tag

<400>  21

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Gly Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  22
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65G SonA mutant with N-terminal His-tag

<400>  22

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Gly Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  23
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63W SonA mutant with N-terminal His-tag

<400>  23

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Trp Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  24
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65W SonA mutant with N-terminal His-tag

<400>  24

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Trp Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  25
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63Q SonA mutant with N-terminal His-tag

<400>  25

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Gln Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  26
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65Q SonA mutant with N-terminal His-tag

<400>  26

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Gln Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  27
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63M SonA mutant with N-terminal His-tag

<400>  27

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Met Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  28
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65M SonA mutant with N-terminal His-tag

<400>  28

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Met Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  29
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63H SonA mutant with N-terminal His-tag

<400>  29

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr His Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  30
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65H SonA mutant with N-terminal His-tag

<400>  30

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val His Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  31
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63K SonA mutant with N-terminal His-tag

<400>  31

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Lys Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  32
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65K SonA mutant with N-terminal His-tag

<400>  32

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Lys Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  33
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63D SonA mutant with N-terminal His-tag

<400>  33

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Asp Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  34
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65D SonA mutant with N-terminal His-tag

<400>  34

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Asp Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  35
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - L63P SonA mutant with N-terminal His-tag

<400>  35

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Pro Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  36
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - I65P SonA mutant with N-terminal His-tag

<400>  36

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Gln Ser Tyr Leu Val Pro Ser His Gly Asn Gly Asp 
65                  70                  75              


<210>  37
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KTLSdel SonA mutant with N-terminal His-tag

<400>  37

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Gly Asp Ser Ser Tyr Gln Ser 
    50                  55                  60                  


Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
65                  70                  


<210>  38
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KTLSext SonA mutant with N-terminal His-tag

<400>  38

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Lys Thr Leu 
    50                  55                  60                  


Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn 
65                  70                  75                  80  


Gly Asp 
        


<210>  39
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KTLSGDSdel SonA mutant with N-terminal His-tag

<400>  39

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Ser Tyr Gln Ser Tyr Leu Val 
    50                  55                  60                  


Ile Ser His Gly Asn Gly Asp 
65                  70      


<210>  40
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - MEKLKTLdel SonA mutant with N-terminal His-tag

<400>  40

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val 
    50                  55                  60                  


Ile Ser His Gly Asn Gly Asp 
65                  70      


<210>  41
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - MEKLKTLext SonA mutant with N-terminal His-tag

<400>  41

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Met Glu Lys Leu 
    50                  55                  60                  


Lys Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser 
65                  70                  75                  80  


His Gly Asn Gly Asp 
                85  


<210>  42
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - QSYdel SonA mutant with N-terminal His-tag

<400>  42

Met His His His His His His Met Ser Gly Leu Ser Asp Phe Phe Thr 
1               5                   10                  15      


Gln Leu Gly Gln Asp Ala Gln Leu Met Glu Asp Tyr Lys Gln Asn Pro 
            20                  25                  30          


Glu Ala Val Met Arg Ala His Gly Leu Thr Asp Glu Gln Ile Asn Ala 
        35                  40                  45              


Val Met Thr Gly Asp Met Glu Lys Leu Lys Thr Leu Ser Gly Asp Ser 
    50                  55                  60                  


Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
65                  70                  75  


<210>  43
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ036_fw primer

<400>  43
actttaagaa ggagatatac catgggatca ctcgtctgtg                             40


<210>  44
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pRMMRJ045_rev primer

<400>  44
gatgatgatg atgatgcatg ttttctcctt attgttaata atgattcaat aac              53


<210>  45
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ044_fw primer

<400>  45
aggagaaaac atgcatcatc atcatcatca catgtctgga ttatcggatt tttttac          57


<210>  46
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pRMMRJ045_rev primer

<400>  46
cgagtgcggc cgcaagcttg tcgacttaat caccattacc atgtg                       45


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - T7_fw primer

<400>  47
taatacgact cactataggg                                                   20


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - T7_rv primer

<400>  48
gctagttatt gctcagcgg                                                    19


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prFM1175 primer

<400>  49
tttaagaagg agatatacat gcatcatcat catcat                                 36


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prFM1176 primer

<400>  50
agtgcggccg caagcttgtt aatcaccatt accatg                                 36


<210>  51
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prFM1177 primer

<400>  51
taagaaggag atatacatgc atcatcatca tcatcacagc agcatgggat cactcgtc         58


<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prFM1178 primer

<400>  52
agtgcggccg caagcttgtt atcccaaatc ttcggg                                 36


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ068 primer

<400>  53
atataacata tgccggcggc                                                   20


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ069 primer

<400>  54
ttatatggat ccttacgcac cgctcgg                                           27


<210>  55
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ066 primer

<400>  55
atataacata tgcaggagac caccg                                             25


<210>  56
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ067 primer

<400>  56
ttatatggat ccttaacgac gcgccg                                            26


<210>  57
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ064 primer

<400>  57
atataacata tgacgaccat cgtccc                                            26


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ063 primer

<400>  58
ttatatggat cctcaggcgg tttcccc                                           27


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ062 primer

<400>  59
atataacata tgagagccgc cccg                                              24


<210>  60
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - prmMRJ063primer

<400>  60
ttatatggat cctcaggcgg tttcccc                                           27


<210>  61
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - F_BstA_pET28HisSumo primer

<400>  61
ccggtggcgc ttccttcgat gtgtccggaa catacatg                               38


<210>  62
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - R_BstA_pET28HisSumo primer

<400>  62
ccgcaagctt tcattccgcc agcgccagc                                         29


<210>  63
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - F_BstMT_pET28HisSumo primer

<400>  63
ccggtggcag cgaggccaaa ggcaggc                                           27


<210>  64
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - R_BstMT_pET28HisSumo primer

<400>  64
gccgcaagct ttcaggccac gctcaggtgg t                                      31


<210>  65
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - F_BstA_coexp_HindIII primer

<400>  65
gcggaagctt aatacgactc actatagggg aattgtgagc g                           41


<210>  66
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - R_BstA_coexp_XhoI primer

<400>  66
aatcctcgag tcaggccacg ctcaggtgg                                         29


<210>  67
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fwd_pET28b_NHis_Pmosselii_Repeat_RiPP primer

<400>  67
gctcgagtgc ggccgcaagc ttgcatgttc atccggcatc ctccatttca tcct             54


<210>  68
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - R_Pmosselii_NHisRepRiPP_HindIII primer

<400>  68
gctcgagtgc ggccgcaagc ttgcatgttc atccggcatc ctccatttca tcct             54


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Rev_pET28b_NdeI_Backbone_Gibson primer

<400>  69
catatggctg ccgcgcggca cca                                               23


<210>  70
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic F_backbone_pET28NHisSumoPmoA primer

<400>  70
gcgcctgaaa gcttgcggcc gcactcga                                          28


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:2 shown in FIG. 3

<400>  71

Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10          


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:2 shown in FIG. 5 and FIG. 7

<400>  72

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:4 shown in FIG. 9 and FIG. 10

<400>  73

Cys His Ala Val Leu Val Val Ile Ile Phe 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:6 shown in FIG. 11 and FIG. 12

<400>  74

Asp Val Ala Glu Leu Ser Gly Gly Glu Leu 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:6 shown in FIG. 12

<400>  75

Asp Val Ile Glu Leu Ser Gly Gly Glu Leu 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:6 shown in FIG. 12

<400>  76

Asp Val Ala Glu Leu Phe Gly Gly Glu Leu 
1               5                   10  


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:6 shown in FIG. 12

<400>  77

Asp Val Ala Glu Ile Gly Ile Ile Asn Thr Phe 
1               5                   10      


<210>  78
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:8 shown in FIG. 13

<400>  78

Thr Pro Pro Thr Ile Thr Val Val Ala Ala Leu Ile Ser Asn Thr Ala 
1               5                   10                  15      


Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr 
            20                  25                  30          


Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Leu 
        35                  40                  45              


Thr Glu Val Ala Val Ala Val Val Glu Val Leu Ala Glu Asp Asp Asp 
    50                  55                  60                  


Lys Pro 
65      


<210>  79
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:8 shown in FIG. 14

<400>  79

Ser Ser Ser Thr Pro Pro Thr Ile Thr Val Val Ala Ala Leu Ile Ser 
1               5                   10                  15      


Asn Thr Ala Thr Glu Val Thr 
            20              


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:8 shown in FIG. 14

<400>  80

Ser Asn Thr Ala Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr 
1               5                   10                  15      


Thr Glu Val 
            


<210>  81
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:8 shown in FIG. 14

<400>  81

Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr Thr Glu Val Thr 
1               5                   10                  15      


Thr Glu Val Leu Thr Glu Val Ala 
            20                  


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:8 shown in FIG. 14

<400>  82

Thr Glu Val Ala Val Ala Val Val Glu Val Leu Ala Glu 
1               5                   10              


<210>  83
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:10 shown in FIG. 15

<400>  83

Pro Asp Asp Pro Asn Val Asp Val Asp Val Asp Ala Asp Val Glu Ala 
1               5                   10                  15      


Asp Ile Glu Thr Glu Val Asp Val Asp Val Asp Val Asp Val Thr Leu 
            20                  25                  30          


Glu Met Phe Leu Glu Glu Asp Leu Glu Arg Ser Glu Pro Gly Ile Asp 
        35                  40                  45              


Phe Val Thr Gly 
    50          


<210>  84
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:10 shown in FIG. 16

<400>  84

Val Glu Ile Pro Asp Asp Pro Asn Val Asp Val Asp Val Asp Ala Asp 
1               5                   10                  15      


Val Glu Ala Asp 
            20  


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:10 shown in FIG. 16

<400>  85

Glu Ile Pro Asp Asp Pro Asn Val Asp Val Asp Val Asp Ala Asp Val 
1               5                   10                  15      


Glu Ala 
        


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:10 shown in FIG. 16

<400>  86

Thr Glu Val Asp Val Asp Val Asp Val Asp Val Thr Leu Glu Met 
1               5                   10                  15  


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:10 shown in FIG. 16

<400>  87

Glu Pro Gly Ile Asp Phe Val Thr Gly 
1               5                   


<210>  88
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:12 shown in FIG. 17

<400>  88

Asp Ala Ala Asp Pro Val Asn Val Asp Val Asp Ile Asp Val Asp Ile 
1               5                   10                  15      


Asp Val Asp Val Asp Val Asp Ile Asp Ile Asp Ile Asp Val Asp Val 
            20                  25                  30          


Asp Val Asp Ile Asp Ile Asp Val Asp Val Asp Phe Ile Ala Val Val 
        35                  40                  45              


Asp Val Asp Val Asp Val Asp Ile Asp Val Asp Ile Asp Val Val Thr 
    50                  55                  60                  


Asp 
65  


<210>  89
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:12 shown in FIG. 18

<400>  89

Ala Asp Pro Val Asn Val Asp Val Asp Ile Asp Val Asp Ile Asp Val 
1               5                   10                  15      


Asp Val Asp 
            


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:12 shown in FIG. 18

<400>  90

Ile Ala Val Val Asp Val Asp Val Asp Val Asp Ile Asp Val Asp 
1               5                   10                  15  


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:12 shown in FIG. 18

<400>  91

Ile Ala Val Val Asp Val Asp Val Asp Val Asp Ile Asp Val Asp Ile 
1               5                   10                  15      


Asp 
    


<210>  92
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:14 shown in FIG. 19

<400>  92

Pro Ile Asn Thr Thr Ser Glu Thr Thr Thr Glu Thr Val Ala Glu Pro 
1               5                   10                  15      


Val Thr Thr Thr Glu Thr Glu Val Val Thr Ser Glu Val Thr Ser Glu 
            20                  25                  30          


Val Thr 
        


<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:14 shown in FIG. 20

<400>  93

Thr Val Ala Glu Pro Val Thr Thr Thr Glu Thr Glu Val Val Thr Ser 
1               5                   10                  15      


<210>  94
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:14 shown in FIG. 20

<400>  94

Thr Val Ala Glu Pro Val Thr Thr Thr Glu Thr Glu Val Val Thr Ser 
1               5                   10                  15      


Glu Val Thr Ser Glu Val Thr 
            20              


<210>  95
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:14 shown in FIG. 20

<400>  95

Thr Val Ala Glu Pro Val Thr Thr Thr Glu Thr Glu Val Val Thr Ser 
1               5                   10                  15      


Glu Val Thr Ser Glu 
            20      


<210>  96
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:16 shown in FIG. 21

<400>  96

Pro Pro Thr Ile Thr Ala Val Val Ala Ile Val Ile Asn Ser Ser Thr 
1               5                   10                  15      


Thr Glu Val Ala Glu Val Thr Glu Val Thr Glu Val Thr Glu Val Thr 
            20                  25                  30          


Glu Val Thr Glu Val Val 
        35              


<210>  97
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:16 shown in FIG. 22

<400>  97

Glu Val Ala Glu Val Thr Glu Val Thr Glu Val Thr Glu Val Thr 
1               5                   10                  15  


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:16 shown in FIG. 22

<400>  98

Thr Ala Val Val Ala Ile Val Ile Asn Ser Ser Thr Thr Glu Val Ala 
1               5                   10                  15      


Glu Val 
        


<210>  99
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:16 shown in FIG. 22

<400>  99

Ala Thr Pro Glu Pro Pro Thr Ile Thr Ala Val Val Ala Ile Val Ile 
1               5                   10                  15      


Asn Ser Ser Thr Thr Glu Val Ala 
            20                  


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:18 shown in FIG. 7D

<400>  100

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Val Leu Val Ile Ser His 
1               5                   10                  15      


Gly Asn Gly Asp 
            20  


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:19 shown in FIG. 7E

<400>  101

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:19 shown in FIG. 7E

<400>  102

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:21 shown in FIG. 7G

<400>  103

Asp Ser Ser Tyr Gln Ser Tyr Gly Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  104
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:22 shown in FIG. 7H

<400>  104

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Gly Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:23 shown in FIG. 7I

<400>  105

Asp Ser Ser Tyr Gln Ser Tyr Trp Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:24 shown in FIG. 7J

<400>  106

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Trp Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:25 shown in FIG. 7K

<400>  107

Asp Ser Ser Tyr Gln Ser Tyr Gln Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  108
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:26 shown in FIG. 7L

<400>  108

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Gln Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:27 shown in FIG. 7M

<400>  109

Asp Ser Ser Tyr Gln Ser Tyr Met Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  110
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:28 shown in FIG. 7N

<400>  110

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Met Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:29 shown in FIG. 7O

<400>  111

Asp Ser Ser Tyr Gln Ser Tyr His Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:30 shown in FIG. 7P

<400>  112

Asp Ser Ser Tyr Gln Ser Tyr Leu Val His Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  113
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:31 shown in FIG. 7Q

<400>  113

Asp Ser Ser Tyr Gln Ser Tyr Lys Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:32 shown in FIG. 7R

<400>  114

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Lys Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  115
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:33 shown in FIG. 7S

<400>  115

Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Asp Val Ile Ser His 
1               5                   10                  15      


Gly Asn Gly Asp 
            20  


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:34 shown in FIG. 7T

<400>  116

Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Asp Ser His 
1               5                   10                  15      


Gly Asn Gly Asp 
            20  


<210>  117
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:35 shown in FIG. 7U

<400>  117

Asp Ser Ser Tyr Gln Ser Tyr Pro Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:36 shown in FIG. 7V

<400>  118

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Pro Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:37 shown in FIG. 7W

<400>  119

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:38 shown in FIG. 7X

<400>  120

Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His 
1               5                   10                  15      


Gly Asn Gly Asp 
            20  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:39 shown in FIG. 7Y

<400>  121

Leu Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15  


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:40 shown in FIG. 7Z

<400>  122

Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10                  15      


<210>  123
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:41 shown in FIG. 7AA

<400>  123

Thr Leu Ser Gly Asp Ser Ser Tyr Gln Ser Tyr Leu Val Ile Ser His 
1               5                   10                  15      


Gly Asn Gly Asp 
            20  


<210>  124
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - Fragment of SEQ ID NO:42 shown in FIG. 7BB

<400>  124

Asp Ser Ser Tyr Leu Val Ile Ser His Gly Asn Gly Asp 
1               5                   10              


<210>  125
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  125

Gly Lys Leu Val Ile Val Gly Ser Gly Ile Gly Ser Ile Gly Gln Phe 
1               5                   10                  15      


Thr Leu Ser Ala Val Ala His Ile Glu Gln Ala Asp Arg Val Phe Phe 
            20                  25                  30          


Val Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Tyr Ser Lys Asn Lys 
        35                  40                  45              


Asn Ser Val Asp Leu Tyr Lys Phe Tyr Asp Asp Lys Lys Pro Arg Met 
    50                  55                  60                  


Asp Thr Tyr Ile Gln Met Ala Glu Val Met Leu Arg Glu Leu Arg Lys 
65                  70                  75                  80  


Gly Tyr Ser Val Val Gly Val Ile Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Arg Ala Ile Ser Ile Ala Arg Asp Glu Gly Tyr Ser 
            100                 105                 110         


Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Asn Leu Phe Ala Asp 
        115                 120                 125             


Ile Gly Ile Asp Pro Ser Arg Pro Gly Cys Leu Thr Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Asn Arg Thr Leu Val Pro Ser Ser His Leu Val 
145                 150                 155                 160 


Leu Phe Gln Val Gly Cys Ile Gly Leu Ser Asp Phe Arg Phe Lys Gly 
                165                 170                 175     


Phe Asp Asn Ile Asn Phe Asp Val Leu Leu Asp Arg Leu Glu Gln Val 
            180                 185                 190         


Tyr Gly Pro Asp His Ala Val Ile His Tyr Met Ala Ala Val Leu Pro 
        195                 200                 205             


Gln Ser Thr Thr Thr Ile Asp Arg Tyr Thr Ile Lys Glu Leu Arg Asp 
    210                 215                 220                 


Pro Val Ile Lys Lys Arg Ile Thr Ala Ile Ser Thr Phe Tyr Leu Pro 
225                 230                 235                 240 


Pro Lys Ala 
            


<210>  126
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  126

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Gln Glu Ala Asp Lys Val Tyr Tyr 
            20                  25                  30          


Ala Ile Thr Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Lys Ser Glu 
        35                  40                  45              


Gly Asp Cys Phe Asp Leu Thr Val Tyr Tyr Asp Lys Asn Lys Ile Arg 
    50                  55                  60                  


Tyr Glu Thr Tyr Val Gln Met Cys Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ala Asp Tyr Asn Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Arg Asp Glu Gly Tyr 
            100                 105                 110         


Arg Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met Phe Ser 
        115                 120                 125             


Asp Leu Gly Phe Asp Pro Ala Val Pro Gly Cys Met Thr Gln Glu Ala 
    130                 135                 140                 


Thr Ala Met Leu Asn His Asn Lys Lys Leu Asp Pro Ser Ile His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ala Val Gly Ile Asp Thr Met Val Phe Asp 
                165                 170                 175     


Asn Arg Lys Phe His Leu Leu Val Asp Arg Leu Glu Glu Asp Phe Gly 
            180                 185                 190         


Pro Asp His Arg Val Val Asn Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Thr Thr Val Met Asp Glu Phe Thr Ile Gly Asp Leu Arg Lys Glu Asp 
    210                 215                 220                 


Val Val Lys Gln Phe Thr Thr Val Ser Thr Phe Tyr Val Pro Pro Arg 
225                 230                 235                 240 


Thr 
    


<210>  127
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  127

Gly Lys Leu Ile Leu Val Gly Thr Gly Val Arg Ser Leu Cys Gln Leu 
1               5                   10                  15      


Thr Leu Glu Ala Ile Asp Glu Ile Glu Arg Ala Asp Val Ile Tyr Tyr 
            20                  25                  30          


Ala Val Arg Asp Ala Thr Thr Glu Gly Phe Ile Lys Lys Arg Asn Lys 
        35                  40                  45              


Glu Ala Ile Asp Leu Tyr Gln Tyr Phe Ile Asn Asp Glu Glu Ile Pro 
    50                  55                  60                  


Glu Ala Asp Ile Tyr Ile Gln Ile Ala Glu Val Met Leu Ala Ala Thr 
65                  70                  75                  80  


Arg Lys Gly Arg Arg Val Val Gly Ala Phe Phe Gly His Pro Gly Leu 
                85                  90                  95      


Phe Met Ser Pro Asn Arg Arg Ala Leu Ala Ile Ala Gln Ala Glu Gly 
            100                 105                 110         


Tyr Thr Ala Lys Ile Leu Pro Gly Val Ser Val Asp Asp Cys Leu Leu 
        115                 120                 125             


Ala Asp Leu Gly Val Asp Pro Ser Phe Ile Gly Cys Leu Thr Cys Glu 
    130                 135                 140                 


Ala Arg Asp Phe Met Ile His Asp His Leu Gly Leu Thr Ser Arg His 
145                 150                 155                 160 


Val Ile Met Tyr Glu Val Gly Tyr Leu Gly Phe Tyr Gly Asp Asp Ser 
                165                 170                 175     


Lys Thr Asp Tyr Phe Glu Tyr Phe Val Asn Arg Leu Glu Glu Ile Tyr 
            180                 185                 190         


Gly Asn Glu His Ser Leu Val Asn Tyr Thr Ala Ala Ile Ser Pro Leu 
        195                 200                 205             


Met Gln Pro Val Ile Asn Thr Leu Thr Ile Gly Asp Leu Arg Lys Pro 
    210                 215                 220                 


Glu Val Arg Lys Gln Ile Thr Ser Ala Ser Thr Leu Tyr Phe Pro Pro 
225                 230                 235                 240 


Lys Glu 
        


<210>  128
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  128

Gly Lys Leu Val Met Val Gly Ser Gly Ile Lys Ser Ile Ser His Met 
1               5                   10                  15      


Thr Leu Glu Thr Val Ser His Ile Glu Gln Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Gly Thr Glu Leu Phe Val Lys Ser Lys Ala Lys 
        35                  40                  45              


Trp Ser Phe Asp Leu Tyr Thr Leu Tyr Asp Asn Asp Lys Asn Arg Tyr 
    50                  55                  60                  


Ile Thr Tyr Val Gln Met Ala Glu Leu Cys Leu Gln Ala Ala Arg Asp 
65                  70                  75                  80  


Gly Phe Phe Ser Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Ser Pro Ser His Arg Ala Ile Gly Ile Ala Lys Arg Glu Gly Ile Glu 
            100                 105                 110         


Ala Tyr Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Ser Phe Thr Gly Cys Gln Thr Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Asp Arg Pro Ile Ser Pro Tyr Ser His Leu Ile 
145                 150                 155                 160 


Val Trp Gln Val Gly Val Val Gly Asp Thr Gly Phe Asn Phe Gly Gly 
                165                 170                 175     


Phe Thr Gln Thr Lys Phe Gln Val Leu Val Asp Arg Leu Glu Glu Val 
            180                 185                 190         


Tyr Gly Ser Asp His Arg Leu Ile His Tyr Phe Ala Ser Thr Leu Ser 
        195                 200                 205             


His Gly Pro Ala His Ile Glu Pro Leu Arg Ile Ser Asp Leu Arg Lys 
    210                 215                 220                 


Pro Glu Val Glu Lys Arg Met Asn Gly Ile Ser Thr Phe Tyr Val Pro 
225                 230                 235                 240 


Gln Ile Gly 
            


<210>  129
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  129

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser His Ile Arg Glu Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Ile Val Cys Asp Pro Ala Thr Glu Ala Phe Ile His Asp Asn Ala Lys 
        35                  40                  45              


Ala Glu Ala Val Asp Leu Thr Val Tyr Tyr Asp Thr Asn Lys Ala Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Val Gln Met Ala Glu Val Met Leu Gln Asp Val Arg 
65                  70                  75                  80  


Gly Gly Lys Asp Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Leu Ala Ile Ala Arg Ser Glu Gly Tyr 
            100                 105                 110         


Lys Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Leu Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ser Val His Gly Cys Ala Thr Phe Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Leu Arg Glu Lys Pro Leu Asn Thr Thr Met His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ala Val Gly Val Asp Asp Met Val Phe Thr 
                165                 170                 175     


Asn Ser Lys Leu His Val Leu Val Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Glu His Gln Val Val His Tyr Ile Gly Ala Val Leu Pro Gly Ser 
        195                 200                 205             


Arg Thr Val Met Asp Thr Phe Thr Val Ala Asp Leu Cys Lys Asp Asp 
    210                 215                 220                 


Val Val Lys Gln Phe Asn Pro Ser Ser Thr Leu Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Ser 
    


<210>  130
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  130

Gly Glu Leu Val Val Val Gly Thr Gly Ile Ala Ser Ile Arg Gln Met 
1               5                   10                  15      


Thr Val Glu Ala Leu Asp Tyr Ile Gln Arg Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Ala Thr Leu Asp Ala Val Thr Glu Thr Phe Ile Lys His His Ala Pro 
        35                  40                  45              


Ser Ala Glu Asp Leu Tyr Gln Tyr Tyr Asp Thr Glu Lys Asn Arg Val 
    50                  55                  60                  


Thr Thr Tyr Val Gln Met Ala Glu Val Ile Leu Ser Ser Val Arg Lys 
65                  70                  75                  80  


Gly Lys Leu Thr Val Ala Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Arg Ala Ile Tyr Ile Ala Arg His Glu Gly Tyr Lys 
            100                 105                 110         


Ala Gln Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ala Ser Ser Gly Cys Ser Met Tyr Glu Ala Ser 
    130                 135                 140                 


Phe Leu Leu Asn Glu Pro Asn Arg Leu Asp Ser Arg His His Leu Ile 
145                 150                 155                 160 


Ile Trp Gln Val Gly Cys Val Gly Lys Glu Ala Met Ile Phe Asp Asn 
                165                 170                 175     


Lys Glu Ile Tyr Lys Leu Ala Asp Tyr Leu Glu Ala Glu Tyr Gly Pro 
            180                 185                 190         


Asp His Pro Val Ile Ala Tyr Leu Ala Ala Ile Gln Pro Phe His Asp 
        195                 200                 205             


Ser Lys Met Asp Lys Met Thr Val Gln Asp Leu Arg Asp Gln Asp Lys 
    210                 215                 220                 


Val Gln Asn Ile Pro Ile Thr Ala Gly Thr Thr Leu Tyr Val Pro Pro 
225                 230                 235                 240 


Lys Lys 
        


<210>  131
<211>  240
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  131

Gly Ser Leu Ile Ile Ala Gly Ser Gly Ile Ser Ser Val Ala His Leu 
1               5                   10                  15      


Thr Leu Glu Thr Val Ser His Leu Lys Asn Ala Asp Asn Val Phe Tyr 
            20                  25                  30          


Leu Val Gly Asp Pro Val Thr Glu Ala Phe Ile Gln Glu Asn Asn Lys 
        35                  40                  45              


Ser Thr Thr Asn Leu Val Ala His Tyr Ala Thr Ser Lys His Arg Tyr 
    50                  55                  60                  


Gln Thr Tyr Val Glu Met Ala Glu Val Met Leu Arg Glu Val Arg Ala 
65                  70                  75                  80  


Gly His Ser Val Phe Gly Ile Phe Tyr Gly His Pro Gly Val Leu Thr 
                85                  90                  95      


Thr Pro Ala His Arg Ala Leu Thr Leu Ala Arg Gln Glu Gly Tyr Glu 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Val Ser Ser Val Asp Tyr Met Phe Ala Asp 
        115                 120                 125             


Leu Glu Leu Glu Pro Gly Gln His Gly Cys Met Ile His Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Ala Arg Asp Arg Arg Leu Asp Pro Ser Val His Asn Ile 
145                 150                 155                 160 


Ile Leu Gln Pro Ser Arg Val Gly Ser Ala Thr Leu Glu Lys Glu Ala 
                165                 170                 175     


Ser Lys Phe Gln Leu Leu Val Asp Arg Leu Val Arg Asp Phe Gly Pro 
            180                 185                 190         


Asp His Lys Ile Val His Tyr Ser Gly Ala Val Leu Pro Gln Ser Ser 
        195                 200                 205             


Ser Ala Met Val Val Phe Val Ile Glu Asn Leu Arg Asn Glu Gln Leu 
    210                 215                 220                 


Ala Asn Gln Ile Arg Ser Thr Ser Ile Leu Tyr Ile Pro Pro Arg Asp 
225                 230                 235                 240 


<210>  132
<211>  245
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  132

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Arg His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ser Asp Lys Ile Tyr Tyr 
            20                  25                  30          


Leu Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Ile Glu Asn Ala Asn 
        35                  40                  45              


Gly Ser Cys Val Ser Leu Tyr Gly Leu Tyr Gly Ile Asp Lys Ile Arg 
    50                  55                  60                  


Tyr Asp Thr Tyr Val Gln Met Ser Glu Val Leu Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ala Gly Phe Asp Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Thr Gln Arg Ala Met Ser Ile Ala Leu Glu Glu Gly Phe 
            100                 105                 110         


Gln Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Leu Phe Ala 
        115                 120                 125             


Asp Leu Arg Val Asp Pro Cys Met Phe Gly Cys Ala Ala Tyr Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Tyr Arg Lys Arg Arg Leu Asn Pro Thr Met Gln Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Lys Arg Phe Thr Ile Ile Lys Leu Thr Ser 
                165                 170                 175     


Pro Asp Thr Gln Asn Ser Lys Phe Gly Leu Leu Val Asp His Leu Glu 
            180                 185                 190         


Glu Asp Tyr Gly Pro Asp His Lys Val Val His Tyr Ile Gly Ala Val 
        195                 200                 205             


Leu Pro Gln Ala Thr Thr Val Ile Gln Pro Tyr Thr Ile Ser Glu Leu 
    210                 215                 220                 


Arg Lys Pro Glu Val Ala Ser Gln Ile Arg Ala Cys Ser Thr Phe Tyr 
225                 230                 235                 240 


Ile Pro Pro Arg Asp 
                245 


<210>  133
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  133

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Glu Gln Ala Asp Lys Val Tyr Tyr 
            20                  25                  30          


Ala Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Lys Ser Lys 
        35                  40                  45              


Val Glu Cys Phe Asp Leu Thr Val Tyr Tyr Asp Lys Asp Lys Ile Arg 
    50                  55                  60                  


Phe Glu Thr Tyr Ile Gln Met Ser Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ala Gly His Ser Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Cys Pro Ser His Arg Ala Ile Ala Ile Ala Leu Ser Glu Gly Tyr 
            100                 105                 110         


Lys Ala Arg Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met Phe Ser 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Leu Pro Gly Cys Thr Thr Gln Glu Ala 
    130                 135                 140                 


Thr His Leu Leu Leu His Asn Lys Lys Leu Asp Pro Ser Met His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Gly Val Gly Ala Asp Thr Met Asn Phe Asp 
                165                 170                 175     


Asn Arg Gln Phe His Gln Leu Val Asp Cys Leu Glu Arg Asp Phe Gly 
            180                 185                 190         


Ser Ser His Lys Val Val His Tyr Ile Gly Ala Val Met Pro Gln Ser 
        195                 200                 205             


Thr Thr Ile Met Asp Glu Phe Ser Ile Ala Asp Leu Arg Lys Glu Glu 
    210                 215                 220                 


Val Val Lys Gln Phe Thr Thr Trp Ser Thr Phe Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  134
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  134

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Val Leu Ser Tyr Leu Gln Glu Ala Asp Lys Ile Tyr Tyr 
            20                  25                  30          


Ala Ile Val Asp Pro Val Thr Glu Ala Phe Ile Gln Asp Lys Ser Lys 
        35                  40                  45              


Gly Arg Cys Phe Asp Leu Arg Val Tyr Tyr Asp Lys Asp Lys Met Arg 
    50                  55                  60                  


Ser Glu Thr Tyr Val Gln Met Ser Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ser Gly Tyr Asn Val Leu Ala Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Cys Pro Thr His Arg Ala Ile Ser Ile Ala Arg Ser Glu Gly Tyr 
            100                 105                 110         


Thr Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met Phe Ser 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Val Pro Gly Cys Met Thr Gln Glu Ala 
    130                 135                 140                 


Thr Ser Leu Leu Ile Tyr Asn Lys Gln Leu Asp Pro Ser Val His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ser Val Gly Val Asp Asn Met Val Phe Asp 
                165                 170                 175     


Asn Lys Gln Phe His Leu Leu Val Asp His Leu Glu Arg Asp Phe Gly 
            180                 185                 190         


Ser Ile His Lys Val Ile His Tyr Val Gly Ala Ile Met Pro Gln Ser 
        195                 200                 205             


Ala Thr Val Met Asp Glu Tyr Thr Ile Ser Asp Leu Arg Lys Glu Asp 
    210                 215                 220                 


Val Val Lys Lys Phe Thr Thr Thr Ser Thr Leu Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Glu 
    


<210>  135
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  135

Gly Glu Leu Val Val Val Gly Thr Gly Ile Ala Ser Leu Arg Gln Leu 
1               5                   10                  15      


Thr Val Glu Ala Leu Asp Tyr Ile Gln Arg Ala Asp Val Val Phe Tyr 
            20                  25                  30          


Ala Thr Leu Asp Ala Val Thr Glu Ala Phe Ile Lys Gln His Ala Lys 
        35                  40                  45              


Ala Ala Glu Asn Leu Tyr Gln Tyr Tyr Asp Thr Glu Lys Asn Arg Asn 
    50                  55                  60                  


Ala Thr Tyr Thr Gln Met Ala Glu Thr Ile Leu Ala Ser Val Arg Lys 
65                  70                  75                  80  


Gly Asn Met Thr Val Ala Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Arg Ala Ile Tyr Ile Ala Arg Gln Glu Gly Tyr Lys 
            100                 105                 110         


Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Asp Ile Asp Pro Ala Ser Ser Gly Cys Ser Met Tyr Glu Ala Ser 
    130                 135                 140                 


Phe Leu Leu Leu Glu Pro Asp Arg Leu Asp Ser Arg His His Leu Ile 
145                 150                 155                 160 


Ile Trp Gln Val Gly Cys Val Gly Lys Glu Ala Met Val Phe Asp Asn 
                165                 170                 175     


Lys Glu Leu Tyr Lys Leu Ala Asp Tyr Leu Glu Ala Glu Tyr Gly Pro 
            180                 185                 190         


Lys His Pro Ala Ile Ala Tyr Leu Ala Ala Ile Gln Pro Phe Asn Asp 
        195                 200                 205             


Ser Lys Met Asp His Met Thr Val Glu Asp Leu Arg Asp Pro Glu Lys 
    210                 215                 220                 


Val Arg Ser Ile Pro Ile Asn Ala Gly Thr Thr Leu Tyr Val Pro Pro 
225                 230                 235                 240 


Lys Lys 
        


<210>  136
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  136

Gly Ser Leu Thr Ile Val Gly Ser Gly Phe Arg Ser Ile Ile Gln Phe 
1               5                   10                  15      


Thr Thr Glu Ala Leu Met His Ile Glu Ala Ala Glu Lys Leu Tyr Tyr 
            20                  25                  30          


Cys Val Leu Asp Ala Ala Thr Arg Gly Phe Ile Lys Ala Lys Asn Ser 
        35                  40                  45              


Asn Ser Val Asp Leu Tyr Glu Cys Tyr Ser Asn Thr Lys Pro Arg Tyr 
    50                  55                  60                  


Glu Thr Tyr Ile Gln Met Thr Glu Ala Met Leu Arg Ser Val Arg Asp 
65                  70                  75                  80  


Gly Leu Lys Ala Thr Val Val Leu Tyr Gly His Pro Gly Val Phe Ile 
                85                  90                  95      


His Pro Ser His Arg Ala Ile Ala Ile Ala Arg Ser Glu Gly Tyr Asp 
            100                 105                 110         


Ala Trp Met Leu Leu Gly Ile Ser Val Glu Asp Tyr Leu Phe Ala Asp 
        115                 120                 125             


Leu Leu Ile Asp Pro Ser Asn Pro Gly Thr Gln Thr Val Glu Ala Thr 
    130                 135                 140                 


Glu Ile Leu Leu Lys Glu Arg Pro Leu Leu Thr Ser Ser His Val Ile 
145                 150                 155                 160 


Ile Tyr Gln Val Gly Cys Ile Gly Asn Phe Thr Phe Asn Phe Ser Gly 
                165                 170                 175     


Ile Lys Asn Asp Lys Phe Asp Ala Leu Val Asp Arg Leu Ile Gln Glu 
            180                 185                 190         


Tyr Gly Pro Asp His Pro Leu Val Asn Tyr Gln Ala Ala Ile Ser Pro 
        195                 200                 205             


Leu Ser Glu Ala Ser Ile Gly Arg His Ile Val Ser Asp Leu Arg Lys 
    210                 215                 220                 


Ala Glu Val Gln Glu Ser Val Thr Gly Ala Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Thr 
            


<210>  137
<211>  245
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  137

Gly Gln Leu Thr Ile Val Gly Ser Gly Ile Ala Ser Ile Asn His Met 
1               5                   10                  15      


Thr Leu Gln Ala Val Ala Cys Ile Glu Thr Ala Asp Val Val Cys Tyr 
            20                  25                  30          


Val Val Ala Asp Gly Ala Thr Glu Ala Phe Ile Arg Lys Lys Asn Glu 
        35                  40                  45              


Asn Cys Ile Asp Leu Tyr Pro Leu Tyr Ser Glu Thr Lys Glu Arg Thr 
    50                  55                  60                  


Asp Thr Tyr Ile Gln Met Ala Glu Phe Met Leu Asn His Val Arg Ala 
65                  70                  75                  80  


Gly Lys Asn Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Cys Pro Thr His Arg Ala Ile Tyr Ile Ala Arg Asn Glu Gly Tyr Arg 
            100                 105                 110         


Ala Val Met Leu Pro Gly Leu Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Thr Val Gly Cys Ile Thr Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Met Leu Val Tyr Asn Arg Pro Leu Asn Ser Ser Ser His Leu Val 
145                 150                 155                 160 


Leu Tyr Gln Val Gly Ile Val Gly Lys Ala Asp Phe Lys Phe Ala Tyr 
                165                 170                 175     


Asp Pro Lys Glu Asn His His Phe Gly Lys Leu Ile Asp Arg Leu Glu 
            180                 185                 190         


Leu Glu Tyr Gly Pro Asp His Thr Val Val His Tyr Ile Ala Pro Ile 
        195                 200                 205             


Phe Pro Thr Glu Glu Pro Val Met Glu Arg Phe Thr Ile Gly Gln Leu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Ser Asp Lys Ile Ala Thr Ile Ser Thr Phe Tyr 
225                 230                 235                 240 


Leu Pro Pro Lys Ala 
                245 


<210>  138
<211>  245
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  138

Gly Gln Leu Thr Ile Val Gly Ser Gly Ile Ala Ser Ile Ser His Leu 
1               5                   10                  15      


Thr Leu Gln Ala Val Ser Ala Ile Glu Asn Ala Asp Ile Val Cys Tyr 
            20                  25                  30          


Val Val Ala Asp Gly Ala Thr Glu Ala Phe Ile Arg Lys Lys Asn Pro 
        35                  40                  45              


Asn Ser Leu Asp Leu Tyr His Leu Tyr Gly Glu Asp Lys Gln Arg Thr 
    50                  55                  60                  


Asp Thr Tyr Ile Gln Met Ala Glu Phe Met Leu Ile Arg Val Arg Gln 
65                  70                  75                  80  


Gly Gln Asn Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Cys Pro Thr His Arg Ala Leu Tyr Ile Ala Arg Ser Glu Gly Tyr Lys 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Leu Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Ser Val Gly Cys Val Thr Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Val Phe Lys Arg Pro Ile Asn Pro Ala Ser His Leu Val 
145                 150                 155                 160 


Leu Tyr Gln Val Gly Ile Val Gly Lys Ser Asn Phe Lys Phe Asp Tyr 
                165                 170                 175     


Thr Ser Asp Glu Asn Ile His Phe Thr Lys Leu Leu Asp Arg Leu Glu 
            180                 185                 190         


Glu Ala Tyr Gly Pro Glu His Ser Val Thr His Tyr Ile Ala Pro Leu 
        195                 200                 205             


Phe Pro Thr Glu Asp Pro Ile Ala Glu Glu Tyr Thr Ile Ala Gln Leu 
    210                 215                 220                 


Arg Leu Pro Glu Ile Arg Asp Lys Ile His Thr Ile Ser Thr Phe Tyr 
225                 230                 235                 240 


Val Pro Pro Lys Thr 
                245 


<210>  139
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  139

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser His Ile Gln Gly Ala Asp Lys Ile His Tyr 
            20                  25                  30          


Ala Val Thr Asp Pro Ala Thr Glu Ala Phe Ile Leu Glu Lys Ser Lys 
        35                  40                  45              


Asp Ser Ser Ser Cys Phe Asp Leu Gly Ile Tyr Tyr Asp Lys Asn Lys 
    50                  55                  60                  


Met Arg Tyr Glu Thr Tyr Val Gln Met Cys Glu Val Met Leu Arg Asp 
65                  70                  75                  80  


Val Arg Gly Gly His Asn Val Leu Gly Ile Phe Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Val Ser Pro Thr His Arg Ala Ile Ala Leu Ala Arg Asp Glu 
            100                 105                 110         


Gly Tyr Thr Ala Lys Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met 
        115                 120                 125             


Phe Ser Asp Leu Gly Phe Asp Pro Ala Phe Pro Gly Cys Met Thr Gln 
    130                 135                 140                 


Glu Ala Thr Ile Leu Leu Val Arg Gly Arg Lys Leu Asp Pro Ser Val 
145                 150                 155                 160 


His Asn Ile Ile Trp Gln Val Gly Gly Val Gly Val Asp Thr Met Val 
                165                 170                 175     


Phe Asp Asn Ala Asn Phe Tyr Ile Leu Val Asp Arg Leu Glu Glu Asp 
            180                 185                 190         


Leu Gly Pro Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro 
        195                 200                 205             


Gln Ser Thr Ala Val Ile Asp Glu Phe Thr Val Ala Gly Leu Arg Lys 
    210                 215                 220                 


Glu Glu Val Val Lys Gln Ile Thr Thr Val Ser Thr Phe Tyr Leu Pro 
225                 230                 235                 240 


Pro Arg Thr 
            


<210>  140
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  140

Gly Ser Leu Thr Leu Ala Gly Ala Gly Val Thr Ser Ile Gly His Leu 
1               5                   10                  15      


Thr Leu Gln Thr Val Ser Ala Ile Glu Asn Ala Asp Ile Val Cys Tyr 
            20                  25                  30          


Ile Leu Asn Asp Pro Val Thr Glu Ala Phe Ile Ile Lys Lys Asn Pro 
        35                  40                  45              


Asn Val Tyr Asp Leu Tyr Gln Leu Tyr Asp Asp Gly Lys Pro Arg Ile 
    50                  55                  60                  


Glu Thr Tyr His Gln Met Val Glu Val Leu Met Ser Lys Val Arg Ser 
65                  70                  75                  80  


Gly Gln Asp Val Val Gly Leu Phe Thr Gly His Pro Gly Val Val Asn 
                85                  90                  95      


Thr Pro Ala Ala Gln Ala Phe Lys Ile Ala Arg Gln Glu Gly Tyr Thr 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Ile Thr Thr Asn Asp Ala Leu Leu Ala Asp 
        115                 120                 125             


Val Val Ala Asp Pro Ala Leu Gly Gly Ala Met Ala Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Asn Asn Asn Arg Val Leu His Pro Glu Met Asn Val Phe 
145                 150                 155                 160 


Ile Gln Gln Val Gly Val Val Gly Asn Lys His Phe Asn Phe Met Glu 
                165                 170                 175     


Met Arg Ser Ser Leu Leu Asp Lys Leu Ile Asp Arg Leu Glu Glu Thr 
            180                 185                 190         


Tyr Gly Gly Glu Lys Glu Ile Ile His Tyr Ile Ala Pro Met Leu Pro 
        195                 200                 205             


Ile Asp Lys Pro Val Met Gln Lys Met Thr Val Ser Asp Leu Lys Lys 
    210                 215                 220                 


Pro Glu Tyr Lys Ala Lys Ile Val Pro Ser Ser Thr Phe Tyr Ile Thr 
225                 230                 235                 240 


Pro Asn Glu 
            


<210>  141
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  141

Gly Ser Leu Thr Ile Val Gly Thr Gly Ile Glu Ser Ile Gly Gln Ile 
1               5                   10                  15      


Thr Leu Gln Ala Ile Ser His Ile Glu Thr Ala Ser Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Val Asp Pro Ala Thr Glu Ala Phe Ile Arg Thr Lys Asn Lys 
        35                  40                  45              


Asn Cys Phe Asp Leu Tyr Pro Tyr Tyr Asp Asn Gly Lys His Arg Met 
    50                  55                  60                  


Asp Thr Tyr Ile Gln Met Ala Glu Val Met Leu Lys Glu Val Arg Asn 
65                  70                  75                  80  


Gly Leu Asp Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Ser Pro Ser His Arg Ala Leu Ala Ile Ala Glu Ser Glu Gly Tyr Lys 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Arg Ile Asp Pro Ser His Pro Gly Cys Met Thr Tyr Glu Ala Ser 
    130                 135                 140                 


Asp Phe Leu Ile Arg Glu Arg Pro Val Asn Ile His Ser His Leu Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Cys Val Gly Val Ala Asp Phe Asn Ser Gly Gly 
                165                 170                 175     


Phe Lys Asn Thr Lys Phe Asp Val Leu Val Asp Arg Leu Glu Gln Glu 
            180                 185                 190         


Tyr Gly Ala Asp His Pro Val Val His Tyr Met Ala Ser Ile Leu Pro 
        195                 200                 205             


Tyr Glu Asp Pro Val Thr Asp Lys Phe Thr Val Ser Gln Phe Arg Asp 
    210                 215                 220                 


Pro Gln Ile Ala Lys Arg Ile Cys Gly Ile Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Glu 
            


<210>  142
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  142

Gly Ser Leu Ile Val Val Gly Thr Gly Ile Glu Ser Ile Gly Gln Met 
1               5                   10                  15      


Thr Leu Gln Ala Leu Ser Tyr Ile Glu Ala Ala Ser Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Ile Asp Pro Ala Thr Glu Ala Phe Ile Leu Thr Lys Asn Lys 
        35                  40                  45              


Asn Cys Val Asp Leu Tyr Gln Tyr Tyr Asp Asn Gly Lys Ser Arg Met 
    50                  55                  60                  


Asp Thr Tyr Thr Gln Met Ala Glu Leu Met Leu Lys Glu Val Arg Asn 
65                  70                  75                  80  


Gly Leu Asp Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ser His Arg Ala Leu Ala Ile Ala Arg Ser Glu Gly Tyr Gln 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Cys Ile Asp Pro Ser Asn Pro Gly Cys Leu Thr Tyr Glu Ala Ser 
    130                 135                 140                 


Asp Phe Leu Ile Arg Glu Arg Pro Val Asn Val His Ser His Leu Ile 
145                 150                 155                 160 


Leu Phe Gln Val Gly Cys Val Gly Ile Ala Asp Phe Asn Phe Ser Gly 
                165                 170                 175     


Phe Asp Asn Ser Lys Phe Thr Ile Leu Val Asp Arg Leu Glu Gln Glu 
            180                 185                 190         


Tyr Gly Pro Asp His Thr Val Val His Tyr Ile Ala Ala Met Met Pro 
        195                 200                 205             


His Gln Asp Pro Val Thr Asp Lys Phe Thr Ile Gly Gln Leu Arg Glu 
    210                 215                 220                 


Pro Glu Ile Ala Lys Arg Val Gly Gly Val Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Ala 
            


<210>  143
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  143

Gly Ser Leu Thr Ile Ala Gly Thr Gly Ile Ala Ser Ile Lys His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ala Glu Lys Val Tyr Tyr 
            20                  25                  30          


Leu Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Asn Ala Ser 
        35                  40                  45              


Gly Thr Cys Phe Asn Leu His Val Phe Tyr Asp Thr Asn Lys His Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Val Gln Met Ala Glu Val Met Leu Leu Asp Val Arg 
65                  70                  75                  80  


Ala Gly His Ser Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Arg Glu Glu Gly Phe 
            100                 105                 110         


Lys Ala His Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Thr His Gly Cys Val Ser Tyr Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Val Arg Asp Lys Pro Leu Leu Pro Ser Ser His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ala Ile Gly Ala Asn Ala Met Val Phe Asp 
                165                 170                 175     


Asn Gly Lys Phe Asn Ile Leu Val Asp Arg Leu Glu Gln Val Phe Gly 
            180                 185                 190         


Pro Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Thr Ser Thr Ile Glu Ala Tyr Thr Ile Ser Asp Leu Arg Lys Gly Asp 
    210                 215                 220                 


Val Val Glu Lys Phe Ser Thr Thr Ser Thr Leu Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Val 
    


<210>  144
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  144

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Lys His Met 
1               5                   10                  15      


Thr Leu Glu Thr Val Ser His Ile Lys Glu Ala Glu Lys Val Tyr Tyr 
            20                  25                  30          


Ile Val Thr Asp Pro Ala Thr Glu Ala Tyr Ile Lys Asp Asn Ala Val 
        35                  40                  45              


Gly Ala Cys Phe Asp Leu Arg Val Phe Tyr Asp Thr Asn Lys Pro Arg 
    50                  55                  60                  


Tyr Glu Ser Tyr Val Gln Met Ser Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Val Gly His Ser Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Lys Glu Glu Gly Phe 
            100                 105                 110         


Gln Ala Arg Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Leu Phe Ala 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Ala His Gly Cys Met Ser Tyr Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Val Arg Asn Lys Pro Leu Asn Thr Ser Thr His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ala Leu Gly Ala Glu Ala Met Val Phe Asp 
                165                 170                 175     


Asn Ala Lys Phe Ser Leu Leu Val Asp Arg Leu Glu Gln Asp Tyr Gly 
            180                 185                 190         


Ser Asp His Lys Val Val His Tyr Ile Gly Ala Ile Leu Pro Gln Ala 
        195                 200                 205             


Asp Pro Thr Val Glu Ala Tyr Ile Val Ala Asp Leu Arg Lys Glu Asp 
    210                 215                 220                 


Val Val Lys Gln Phe Asn Ala Ile Ser Thr Leu Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Val 
    


<210>  145
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  145

Gly Ser Leu Thr Ile Ala Gly Thr Gly Ile Ala Ser Ile Lys His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ala Glu Lys Val Tyr Tyr 
            20                  25                  30          


Leu Val Ala Asp Pro Ala Thr Glu Ala Phe Ile His Asp Asn Ala Ser 
        35                  40                  45              


Gly Thr Cys Phe Asn Leu His Val Phe Tyr Asp Thr Asn Lys Leu Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Val Gln Met Ala Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ala Gly Asn Ser Val Leu Gly Leu Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Val Ala Arg Glu Glu Gly Phe 
            100                 105                 110         


Lys Ala Gln Thr Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Ser His Gly Cys Val Ser Tyr Glu Ala 
    130                 135                 140                 


Thr Asp Leu Leu Ala Arg Asp Lys Pro Leu Leu Pro Ser Ser His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ala Ile Gly Ala Asn Ala Met Val Phe Asp 
                165                 170                 175     


Asn Gly Lys Phe Asn Val Leu Val Asp Arg Leu Glu Arg Asp Phe Gly 
            180                 185                 190         


Pro Asn His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Thr Ser Lys Val Glu Gln Tyr Thr Val Ala Asp Leu Arg Lys Asp Tyr 
    210                 215                 220                 


Val Val Lys Thr Phe Thr Thr Thr Ser Thr Leu Tyr Val Pro Pro Cys 
225                 230                 235                 240 


Val 
    


<210>  146
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  146

Gly Gly Leu Val Val Val Gly Ser Gly Ile Arg Ser Val Ser Gln Leu 
1               5                   10                  15      


Thr Leu Glu Ala Val Met His Ile Glu Lys Ala Asp Thr Val Leu Tyr 
            20                  25                  30          


Cys Val Cys Asp Pro Ser Thr Glu Gly Phe Ile Lys Arg Lys Asn Lys 
        35                  40                  45              


Asn Ala Ile Asp Ile Tyr Gly Tyr Tyr Ser Asp Leu Lys Glu Arg Pro 
    50                  55                  60                  


Asp Ala Phe Val Gln Met Ala Glu Val Ile Leu Arg Glu Val Arg Lys 
65                  70                  75                  80  


Gly Ile Asn Val Val Ala Val Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


His Pro Ser Arg Arg Ala Leu Ala Ile Ala Lys Lys Glu Gly Tyr Ala 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Leu Val Asn Pro Ser Phe Pro Gly Ala Gln Leu Val Glu Ala Ser 
    130                 135                 140                 


Asp Ile Val Tyr Arg Ala Arg Pro Leu Ala Thr Ser Cys His Val Val 
145                 150                 155                 160 


Ile Phe Gln Ala Ala Cys Phe Gly His Trp Lys Tyr Asn Phe Thr Ala 
                165                 170                 175     


Phe Glu Asn Gly Lys Phe Asp His Leu Val Asn Arg Leu Gln Lys Asp 
            180                 185                 190         


Tyr Gly Pro Asp His Pro Ile Val Ser Tyr Met Ala Ala Val Ser Pro 
        195                 200                 205             


Leu Glu Asp Pro Val Ile Asn Arg His Thr Ile Ser Asp Leu Tyr Lys 
    210                 215                 220                 


Ala Asp Val Lys Lys Glu Ile Thr Pro Asn Cys Thr Leu Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Asp 
            


<210>  147
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  147

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ala Tyr Ile Lys Glu Ser His Lys Val Phe Tyr 
            20                  25                  30          


Leu Val Cys Asp Pro Val Thr Glu Ala Phe Ile Gln Glu Asn Gly Lys 
        35                  40                  45              


Gly Pro Cys Ile Asn Leu Ser Ile Tyr Tyr Asp Ser Gln Lys Ser Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Leu Gln Met Cys Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Asn Gly Leu Asp Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Leu Ala Arg Glu Glu Gly Phe 
            100                 105                 110         


Asn Ala Lys Met Leu Ala Gly Val Ser Ala Glu Asp Cys Leu Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ala Ser Phe Gly Cys Met Thr Cys Glu Ala 
    130                 135                 140                 


Ser Glu Leu Leu Ile Arg Asn Arg Pro Leu Asn Pro Tyr Ile His Asn 
145                 150                 155                 160 


Val Ile Trp Gln Val Gly Ser Val Gly Val Thr Asp Met Thr Phe Asn 
                165                 170                 175     


Asn Asn Lys Phe Pro Ile Leu Ile Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Asn His Thr Val Ile His Tyr Val Gly Arg Val Ile Pro Gln Ser 
        195                 200                 205             


Val Ser Lys Ile Glu Thr Phe Thr Ile Ala Asp Leu Arg Lys Glu Glu 
    210                 215                 220                 


Val Met Asn His Phe Asp Ala Ile Ser Thr Leu Tyr Val Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  148
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  148

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Arg His Met 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Ala Ile Lys Ser Ala Asp Lys Val Tyr Tyr 
            20                  25                  30          


Thr Val Cys Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Asn Ala Thr 
        35                  40                  45              


Gly Ser Cys Ser Asp Leu Thr Val Tyr Tyr Asp Lys Glu Lys Ser Arg 
    50                  55                  60                  


Tyr Asp Thr Tyr Val Gln Met Cys Glu Val Met Leu Arg Glu Val Arg 
65                  70                  75                  80  


Ala Gly His Asn Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Arg Ala Glu Gly Tyr 
            100                 105                 110         


Lys Ala Glu Met Leu Ala Gly Val Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Gly Phe Asp Pro Ala Ala His Gly Cys Val Thr Tyr Glu Ala 
    130                 135                 140                 


Thr Glu Met Leu Leu Arg Lys Lys Gln Leu Asn Pro Ala Thr His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Gly Val Gly Val Ser Asn Met Ile Phe Asp 
                165                 170                 175     


Asn Ala Arg Phe His Leu Leu Val Asp Arg Leu Glu Asp Thr Phe Gly 
            180                 185                 190         


Pro Asp His Gln Val Val His Tyr Ile Gly Ala Val Leu Pro Leu Ser 
        195                 200                 205             


Val Lys Thr Met Glu Thr Tyr Thr Ile Ala Asp Leu Arg Lys Glu Asp 
    210                 215                 220                 


Val Val Ala Gln Phe Asn Pro Thr Ser Thr Leu Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  149
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  149

Gly Ser Leu Thr Ile Val Gly Thr Gly Ile Glu Ser Ile Gly Gln Met 
1               5                   10                  15      


Thr Leu Gln Thr Leu Ser Tyr Ile Glu Ala Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Ile Asp Pro Ala Thr Glu Ala Phe Ile Leu Thr Lys Asn Lys 
        35                  40                  45              


Asp Cys Val Asp Leu Tyr Gln Tyr Tyr Asp Asn Gly Lys Ser Arg Met 
    50                  55                  60                  


Asp Thr Tyr Thr Gln Met Ser Glu Val Met Leu Arg Glu Val Arg Lys 
65                  70                  75                  80  


Gly Leu Asp Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ser Leu Arg Ala Leu Ala Ile Ala Lys Ser Glu Gly Phe Lys 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Cys Ile Asp Pro Ser Asn Pro Gly Cys Leu Thr Tyr Glu Ala Ser 
    130                 135                 140                 


Asp Phe Leu Ile Arg Glu Arg Pro Thr Asn Ile Tyr Ser His Phe Ile 
145                 150                 155                 160 


Leu Phe Gln Val Gly Cys Val Gly Ile Ala Asp Phe Asn Phe Thr Gly 
                165                 170                 175     


Phe Glu Asn Ser Lys Phe Gly Ile Leu Val Asp Arg Leu Glu Lys Glu 
            180                 185                 190         


Tyr Gly Ala Glu His Pro Val Val His Tyr Ile Ala Ala Met Leu Pro 
        195                 200                 205             


His Glu Asp Pro Val Thr Asp Gln Trp Thr Ile Gly Gln Leu Arg Glu 
    210                 215                 220                 


Pro Glu Phe Tyr Lys Arg Val Gly Gly Val Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Glu 
            


<210>  150
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  150

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Arg His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser His Ile Glu Arg Ala Asp Lys Val Tyr Tyr 
            20                  25                  30          


Leu Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Lys Ser Lys 
        35                  40                  45              


Gly Asp Tyr Val Asp Leu Ala Ile Tyr Tyr Asp Lys Asp Lys Asn Arg 
    50                  55                  60                  


Tyr Glu Ser Tyr Val Gln Met Ser Glu Val Ile Leu Asn Asp Val Arg 
65                  70                  75                  80  


Ala Gly Tyr Asn Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Thr Val Ala Ile Ala Arg Asp Glu Gly Tyr 
            100                 105                 110         


Arg Val Asn Met Leu Pro Gly Val Ser Ala Gln Asp Tyr Met Phe Ser 
        115                 120                 125             


Asp Ile Gly Phe Asp Pro Ala Ile Pro Gly Cys Thr Ile Gln Glu Ala 
    130                 135                 140                 


Ser Thr Ile Leu Phe Leu Asp Lys Arg Leu Asp Pro Thr Val His Asn 
145                 150                 155                 160 


Ile Ile Gly Gln Val Gly Cys Val Gly Val Gly Thr Met Ala Phe Asp 
                165                 170                 175     


Asn Arg Gln Phe His Leu Leu Val Asp His Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Glu His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Ala Thr Val Lys Asp Glu Phe Lys Ile Ala Asp Leu Arg Lys Asp Asp 
    210                 215                 220                 


Val Val Lys Gln Ile Ser Thr Ile Ser Thr Phe Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Gln 
    


<210>  151
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  151

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ala Leu Ile Lys Glu Ala Asp Lys Ile Phe Tyr 
            20                  25                  30          


Ala Val Thr Asp Pro Ala Thr Glu Cys Tyr Ile Gln Glu Asn Ser Arg 
        35                  40                  45              


Gly Asp His Phe Asp Leu Thr Thr Phe Tyr Asp Thr Asn Lys Lys Arg 
    50                  55                  60                  


Tyr Glu Ser Tyr Val Gln Met Ser Glu Val Met Leu Arg Glu Val Arg 
65                  70                  75                  80  


Ala Gly Arg Asn Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ala Pro Ser His Arg Ala Ile Ala Ile Ala Arg Glu Glu Gly Phe 
            100                 105                 110         


Gln Ala Lys Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Gly Phe Asp Pro Ser Thr Gln Gly Cys Met Thr Gln Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Val Arg Asn Lys Lys Leu Asp Pro Ser Val His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ser Val Gly Val Asp Thr Met Val Phe Asp 
                165                 170                 175     


Asn Gly Lys Phe His Leu Leu Val Glu Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Leu Asp His Lys Ile Gln His Tyr Ile Gly Ala Ile Leu Pro Gln Ser 
        195                 200                 205             


Val Thr Val Lys Asp Ala Phe Ala Ile Arg Asp Leu Arg Lys Glu Glu 
    210                 215                 220                 


Val Leu Lys Gln Phe Thr Thr Thr Ser Thr Phe Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Ala 
    


<210>  152
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  152

Gly Glu Leu Val Val Val Gly Thr Gly Ile Ala Ser Leu Arg Gln Met 
1               5                   10                  15      


Thr Val Glu Ala Leu Asp Tyr Ile Gln Arg Ala Asp Met Val Phe Tyr 
            20                  25                  30          


Val Val Leu Asp Ala Met Thr Glu Cys Phe Ile Gln Thr His Ala Lys 
        35                  40                  45              


Lys His His Asp Leu Tyr Gln Tyr Tyr Asp Lys Asn Lys Pro Arg Asn 
    50                  55                  60                  


Ala Ser Tyr Val Gln Met Ala Glu Leu Met Val Gln Ser Val Arg Asp 
65                  70                  75                  80  


Gly Asn Leu Thr Val Ala Val Tyr Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Phe Pro Thr His Arg Ala Ile His Ile Ala Arg Glu Glu Gly Tyr Lys 
            100                 105                 110         


Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Thr Thr Gly Cys Ser Met Phe Glu Ala Thr 
    130                 135                 140                 


Tyr Leu Leu Asn Glu Pro Asp Arg Leu Asp Pro Arg Asn His Val Ile 
145                 150                 155                 160 


Ile Trp Gln Pro Gly Cys Val Gly Lys Ser Thr Met Val Phe Asp Asn 
                165                 170                 175     


Ser Glu Ile His Glu Leu Ala Asp Tyr Leu Glu Lys Thr Tyr Gly Pro 
            180                 185                 190         


Glu Tyr Pro Ile Ile Ala Tyr Leu Ala Ala Val Arg Pro Phe Asn Asp 
        195                 200                 205             


Pro Gln Ile Asp Lys Leu Met Val Lys Asp Leu Arg Asp Leu Glu Lys 
    210                 215                 220                 


Leu Lys Ala Ile Pro Phe Asn Ala Ala Thr Thr Leu Tyr Ile Pro Pro 
225                 230                 235                 240 


Lys Thr 
        


<210>  153
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  153

Gly Ser Leu Thr Ile Val Gly Thr Gly Ile Glu Ser Ile Gly Gln Met 
1               5                   10                  15      


Thr Leu Gln Ala Leu Ser Tyr Ile Glu Ala Ala Ala Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Ile Asp Pro Ala Thr Glu Ala Phe Ile Leu Thr Lys Asn Lys 
        35                  40                  45              


Asn Cys Val Asp Leu Tyr Gln Tyr Tyr Asp Asn Gly Lys Ser Arg Leu 
    50                  55                  60                  


Asn Thr Tyr Thr Gln Met Ser Glu Leu Met Val Arg Glu Val Arg Lys 
65                  70                  75                  80  


Gly Leu Asp Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ser His Arg Ala Leu Ala Ile Ala Lys Ser Glu Gly Tyr Arg 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Cys Ile Asp Pro Ser Asn Pro Gly Cys Leu Thr Tyr Glu Ala Ser 
    130                 135                 140                 


Asp Phe Leu Ile Arg Asp Arg Pro Val Ser Ile His Ser His Leu Val 
145                 150                 155                 160 


Leu Phe Gln Val Gly Cys Val Gly Ile Ala Asp Phe Asn Phe Thr Gly 
                165                 170                 175     


Phe Asp Asn Asn Lys Phe Gly Val Leu Val Asp Arg Leu Glu Gln Glu 
            180                 185                 190         


Tyr Gly Ala Glu His Pro Val Val His Tyr Ile Ala Ala Met Met Pro 
        195                 200                 205             


His Gln Asp Pro Val Thr Asp Lys Tyr Thr Val Ala Gln Leu Arg Glu 
    210                 215                 220                 


Pro Glu Ile Ala Lys Arg Val Gly Gly Val Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Ala 
            


<210>  154
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  154

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Arg His Met 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ala His Val Gln Glu Ala Asp Ile Val Phe Tyr 
            20                  25                  30          


Val Val Ala Asp Pro Val Thr Glu Ala Tyr Ile Lys Lys Asn Ala Arg 
        35                  40                  45              


Gly Pro Cys Lys Asp Leu Glu Val Leu Phe Asp Lys Asp Lys Val Arg 
    50                  55                  60                  


Tyr Asp Thr Tyr Val Gln Met Ala Glu Thr Met Leu Asn Ala Val Arg 
65                  70                  75                  80  


Glu Gly Gln Lys Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser Arg Arg Ala Leu Ser Ile Ala Arg Lys Glu Gly Tyr 
            100                 105                 110         


Gln Ala Lys Met Leu Pro Gly Ile Ser Ser Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ala Val His Gly Cys Cys Ala Tyr Glu Ala 
    130                 135                 140                 


Thr Gln Leu Leu Leu Arg Glu Val Ser Leu Asp Thr Ala Met Ser Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Gly Val Gly Val Ser Lys Ile Asp Phe Glu 
                165                 170                 175     


Asn Ser Lys Val Lys Leu Leu Val Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Asp His His Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Ala Thr Val Gln Asp Val Leu Lys Ile Ser Asp Leu Arg Lys Glu Glu 
    210                 215                 220                 


Ile Val Ala Gln Phe Asn Ser Cys Ser Thr Leu Tyr Val Pro Pro Leu 
225                 230                 235                 240 


Thr 
    


<210>  155
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  155

Gly Ser Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Val Ala Tyr Leu Ala Glu Ala Asp Ser Val Phe Tyr 
            20                  25                  30          


Ile Val Ala Asp Pro Val Thr Glu Ala Phe Ile His Lys Asn Ala Lys 
        35                  40                  45              


Val Pro Cys Gln Asp Leu His Val Phe Tyr Asp Lys Asp Lys Ser Arg 
    50                  55                  60                  


Tyr Asp Thr Tyr Val Gln Met Ala Glu Thr Met Leu Asn Ser Val Arg 
65                  70                  75                  80  


Ala Gly Glu Lys Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser Arg Arg Ala Leu Ala Ile Ala Arg Glu Glu Gly Tyr 
            100                 105                 110         


Glu Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ala Thr His Gly Cys Cys Ala Tyr Glu Ala 
    130                 135                 140                 


Thr His Ile Leu Leu Lys Asn Ile Pro Leu Asp Thr Ser Ile Asn Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Gly Val Gly Val Thr Lys Ile Asp Phe Glu 
                165                 170                 175     


Asn Ser Lys Phe Lys Phe Leu Val Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Leu Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Ala Thr Val Lys Glu Val Tyr Thr Ile Ser Asp Leu Arg Lys Pro Glu 
    210                 215                 220                 


Val Ala Thr Gln Phe Asn Ala Cys Ser Thr Leu Tyr Val Pro Pro Arg 
225                 230                 235                 240 


Lys 
    


<210>  156
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  156

Gly Thr Leu Val Ile Ala Gly Ser Gly Ile Ala Ser Ile Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser His Ile Lys Glu Ser Asp Arg Val Tyr Tyr 
            20                  25                  30          


Ile Val Gly Asp Pro Ala Thr Glu Ala Phe Ile Gln Asp Asn Ala Ser 
        35                  40                  45              


Gly Thr Cys Phe Asp Leu Thr Ile Phe Tyr Asp Thr Asn Lys Val Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Val Gln Met Cys Glu Val Met Leu Arg Asp Val Arg 
65                  70                  75                  80  


Ala Gly His Thr Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Arg Asp Glu Gly Tyr 
            100                 105                 110         


Lys Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Leu Phe Ala 
        115                 120                 125             


Asp Leu Gly Phe Asp Pro Ala Thr His Gly Cys Thr Ser Tyr Glu Ala 
    130                 135                 140                 


Thr Asp Leu Leu Val Arg Asn Lys Pro Leu Asn Ala Ser Thr His Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Gly Val Gly Val Gly Thr Met Val Phe Asp 
                165                 170                 175     


Asn Ala Lys Phe His Leu Leu Val Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Ser His Thr Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Ile Thr Thr Met Asp Lys Leu Thr Ile Ala Asp Leu Arg Lys Asp Ala 
    210                 215                 220                 


Val Val Lys Gln Phe Asn Pro Thr Ser Thr Phe Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  157
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  157

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Val Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ser Glu Lys Ile Phe Tyr 
            20                  25                  30          


Leu Val Cys Asp Pro Val Thr Glu Ala Tyr Ile Gln Asp Asn Thr Thr 
        35                  40                  45              


Ala Asp Cys Phe Asp Leu Ser Val Phe Tyr Gly Lys Asn Lys Gly Arg 
    50                  55                  60                  


His Asp Ser Tyr Ile Gln Met Cys Glu Val Met Leu Lys Ala Val Arg 
65                  70                  75                  80  


Ala Gly His Asp Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Val Ala Arg Gln Glu Gly Tyr 
            100                 105                 110         


Lys Ala Lys Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ser Leu Ser Gly Cys Lys Thr Cys Glu Ala 
    130                 135                 140                 


Thr Glu Ile Leu Leu Arg Asp Lys Pro Leu Asp Pro Ser Ile Gln Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ser Val Gly Val Val Asp Met Glu Phe Glu 
                165                 170                 175     


Lys Ser Lys Phe Gln Leu Leu Val Asp Arg Leu Glu Lys Asp Phe Gly 
            180                 185                 190         


Pro Gly His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Thr Thr Thr Met Asp Thr Phe Thr Ile Ala Asp Leu Arg Lys Glu Asp 
    210                 215                 220                 


Val Ala Lys Gln Phe Gly Thr Ile Ser Thr Leu Tyr Val Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  158
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  158

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Cys Val Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ser Asp Lys Leu Phe Tyr 
            20                  25                  30          


Leu Val Cys Asp Pro Val Thr Glu Ala Phe Ile Gln Asp Asn Ala Thr 
        35                  40                  45              


Gly Asp Cys Phe Asp Leu Ser Val Phe Tyr Asp Lys Asn Lys Ser Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Ile Gln Met Cys Glu Val Met Leu Lys Ala Val Arg 
65                  70                  75                  80  


Ala Gly His His Val Leu Gly Val Phe Tyr Gly His Pro Gly Val Leu 
                85                  90                  95      


Val Ser Pro Ser Tyr Arg Ala Ile Ala Val Ala Arg Glu Glu Gly Tyr 
            100                 105                 110         


Lys Ala Arg Met Leu Pro Gly Ile Ser Ala Glu Asp Tyr Leu Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Cys Phe Pro Ser Gly Cys Asn Thr Tyr Glu 
    130                 135                 140                 


Ala Thr Glu Leu Leu Leu Arg Asp Arg Ser Leu Asp Pro Ser Ile His 
145                 150                 155                 160 


Asn Ile Ile Trp Gln Val Gly Ser Val Gly Val Thr Asp Met Glu Phe 
                165                 170                 175     


Glu Lys Ser Lys Leu Asn Leu Leu Val Asp Arg Leu Glu Asn Asp Phe 
            180                 185                 190         


Gly Pro Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln 
        195                 200                 205             


Ser Thr Thr Thr Met Asp Thr Phe Ala Val Ser Asp Leu His Lys Glu 
    210                 215                 220                 


Asp Val Ala Lys Gln Phe Gly Thr Ile Ser Thr Leu Tyr Ile Pro Pro 
225                 230                 235                 240 


Arg Asp 
        


<210>  159
<211>  241
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  159

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Ala His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Lys Glu Ser Asp Lys Leu Phe Tyr 
            20                  25                  30          


Leu Val Cys Asp Pro Val Thr Glu Ala Phe Ile Gln Asp Asn Ala Thr 
        35                  40                  45              


Gly Asp Phe Phe Asp Leu Ser Val Phe Tyr Asp Lys Asn Lys Ser Arg 
    50                  55                  60                  


Tyr Asp Ser Tyr Ile Gln Met Cys Glu Ile Met Leu Arg Ala Val Arg 
65                  70                  75                  80  


Ala Gly His Ser Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Ile Ala Val Ala Arg Glu Glu Gly Tyr 
            100                 105                 110         


Lys Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Glu Phe Asp Pro Ser Gln Ser Thr Cys Asn Thr Tyr Glu Ala 
    130                 135                 140                 


Thr Glu Leu Leu Leu Arg Asp Arg Pro Leu Asp Pro Ala Ile Gln Asn 
145                 150                 155                 160 


Ile Ile Trp Gln Val Gly Ser Val Gly Val Val Asp Met Glu Phe Glu 
                165                 170                 175     


Lys Ser Lys Phe His Leu Leu Val Asp Arg Leu Glu Gln Asp Phe Gly 
            180                 185                 190         


Pro Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Thr Thr Thr Met Asp Ile Phe Thr Ile Ser Asp Leu Arg Lys Glu Asn 
    210                 215                 220                 


Val Ala Lys Gln Phe Gly Thr Ile Ser Thr Leu Tyr Ile Pro Pro Arg 
225                 230                 235                 240 


Asp 
    


<210>  160
<211>  240
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  160

Gly Thr Leu Thr Ile Ala Gly Ser Gly Ile Ala Ser Ile Gly His Ile 
1               5                   10                  15      


Thr Leu Glu Thr Leu Ser Tyr Ile Gln Glu Ala Asp Lys Ile His Tyr 
            20                  25                  30          


Ala Val Ala Asp Pro Ala Thr Glu Ala Phe Ile Leu Asp Lys Ser Lys 
        35                  40                  45              


Asp Ser Ser His Cys Phe Asp Leu Thr Val Tyr Tyr Asp Thr Asn Lys 
    50                  55                  60                  


Met Arg Tyr Glu Thr Tyr Val Gln Met Cys Glu Val Met Leu Arg Asp 
65                  70                  75                  80  


Val Arg Gly Gly Tyr Asn Val Leu Gly Ile Phe Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Val Ser Pro Ser His Arg Ala Ile Ala Ile Ala Arg Asp Glu 
            100                 105                 110         


Gly Tyr Ile Ala Lys Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met 
        115                 120                 125             


Phe Ser Asp Ile Gly Phe Asp Pro Ala Val Pro Gly Cys Met Ser Gln 
    130                 135                 140                 


Glu Ala Thr Gly Leu Leu Val Cys Lys Lys Lys Leu Asp Pro Ser Ile 
145                 150                 155                 160 


His Asn Ile Ile Trp Gln Val Gly Ser Val Gly Val Asp Thr Met Asn 
                165                 170                 175     


Arg Glu Phe His Ile Leu Val Asp Arg Leu Glu Glu Asp Phe Gly Leu 
            180                 185                 190         


Asp His Lys Val Val His Tyr Ile Gly Ala Val Leu Pro Gln Ser Thr 
        195                 200                 205             


Thr Val Met Asp Glu Phe Thr Ile Ala Asp Leu Arg Lys Glu Glu Val 
    210                 215                 220                 


Val Lys Gln Ile Thr Thr Thr Ser Thr Phe Tyr Leu Pro Pro Arg Ser 
225                 230                 235                 240 


<210>  161
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  161

Gly Ser Leu Thr Ile Ala Gly Thr Gly Ile Ala Thr Leu Ala His Met 
1               5                   10                  15      


Thr Leu Glu Thr Val Ser His Ile Lys Glu Ala Asp Lys Val Tyr Tyr 
            20                  25                  30          


Ile Val Thr Asp Pro Val Thr Gln Ala Phe Ile Glu Glu Asn Ala Lys 
        35                  40                  45              


Gly Pro Thr Phe Asp Leu Ser Val Tyr Tyr Asp Ala Asp Lys Tyr Arg 
    50                  55                  60                  


Tyr Thr Ser Tyr Val Gln Met Ala Glu Val Met Leu Asn Ala Val Arg 
65                  70                  75                  80  


Glu Gly Cys Asn Val Leu Gly Leu Phe Tyr Gly His Pro Gly Ile Phe 
                85                  90                  95      


Val Ser Pro Ser His Arg Ala Leu Ala Ile Ala Arg Glu Glu Gly Tyr 
            100                 105                 110         


Glu Ala Arg Met Leu Pro Gly Val Ser Ala Glu Asp Tyr Met Phe Ala 
        115                 120                 125             


Asp Leu Gly Leu Asp Pro Ala Leu Pro Gly Cys Val Cys Tyr Glu Ala 
    130                 135                 140                 


Thr Asn Phe Leu Ile Arg Asn Lys Pro Leu Asn Pro Ala Thr His Asn 
145                 150                 155                 160 


Ile Leu Trp Gln Val Gly Ala Val Gly Ile Thr Ala Met Asp Phe Glu 
                165                 170                 175     


Asn Ser Lys Phe Ser Leu Leu Val Asp Arg Leu Glu Arg Asp Leu Gly 
            180                 185                 190         


Pro Asn His Lys Val Val His Tyr Val Gly Ala Val Leu Pro Gln Ser 
        195                 200                 205             


Ala Thr Ile Met Glu Thr Tyr Thr Ile Ala Glu Leu Arg Lys Pro Glu 
    210                 215                 220                 


Val Ile Lys Arg Ile Ser Thr Thr Ser Ser Thr Phe Tyr Ile Pro Pro 
225                 230                 235                 240 


Arg Asp 
        


<210>  162
<211>  242
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  162

Gly Ser Leu Ile Ile Ala Gly Ser Gly Ile Ala Ser Val Ala His Phe 
1               5                   10                  15      


Thr Leu Glu Thr Val Ser His Leu Lys Asn Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Leu Val Asn Asp Pro Val Thr Glu Ala Phe Ile Gln Glu Asn Asn Pro 
        35                  40                  45              


Asp Thr Phe Asp Leu Val Thr Phe Tyr Ser Glu Thr Lys Pro Arg Tyr 
    50                  55                  60                  


His Ser Tyr Val Glu Met Ala Glu Ile Met Leu Lys Glu Val Arg Ala 
65                  70                  75                  80  


Gly His Lys Val Leu Gly Ile Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


His Pro Ser Arg Arg Ala Leu Phe Ile Ala Arg Gln Glu Asn Tyr Glu 
            100                 105                 110         


Ala Arg Met Leu Pro Gly Ile Ser Ser Glu Asp Tyr Met Phe Ala Asp 
        115                 120                 125             


Leu Glu Leu Asp Pro Ala Glu Phe Gly Cys Met Thr Cys Glu Ala Thr 
    130                 135                 140                 


Glu Leu Ile Ala Arg Asn Arg Pro Leu Asn Thr Ser Val His Asn Ile 
145                 150                 155                 160 


Ile Trp Gln Ala Gly Ile Val Gly Val Ser Thr Leu Glu Tyr Gln Glu 
                165                 170                 175     


Ser Lys Phe Gln Leu Leu Val Asp Arg Leu Glu Arg Asp Phe Gly Pro 
            180                 185                 190         


Glu His Lys Val Val His Tyr Val Gly Ala Ile Arg Met Thr Pro Gln 
        195                 200                 205             


Ala Gln Ser Ala Met Val Val Tyr Ser Ile Gln Glu Leu Arg Asn Pro 
    210                 215                 220                 


Ala Val Ala Asn Phe Ile Asn Ser Gly Ser Thr Leu Tyr Val Pro Pro 
225                 230                 235                 240 


Arg Leu 
        


<210>  163
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  163

Gly Arg Leu Val Met Val Gly Ser Gly Ile Lys Ser Ile Ala His Leu 
1               5                   10                  15      


Thr Leu Glu Ala Ile Gly His Ile Glu Gln Ala Asp Lys Val Phe Phe 
            20                  25                  30          


Val Val Ala Asp Met Thr Thr Ala Ala Phe Ile His Ser Arg Asn Ala 
        35                  40                  45              


Asn Ala Val Asp Met Tyr Asn Leu Tyr Asp Ile Gly Lys Pro Arg Tyr 
    50                  55                  60                  


His Thr Tyr Val Gln Met Ala Glu Arg Met Leu Arg Glu Val Arg Asn 
65                  70                  75                  80  


Gly Phe Tyr Val Val Gly Val Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


Asn Pro Ser His Arg Ala Ile Ala Ile Ala Arg Gln Glu Gly His Gln 
            100                 105                 110         


Ala Phe Met Leu Pro Gly Ile Ser Ala Glu Ala Cys Leu Phe Ala Asp 
        115                 120                 125             


Val Gly Ile Asp Pro Ser Thr Ser Gly Cys Gln Thr Ile Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Asn Arg Pro Ile Asn Thr Gly Ser His Leu Ile 
145                 150                 155                 160 


Ile Phe Gln Val Gly Ile Val Gly Asp Ser Gly Phe His Pro Gln Gly 
                165                 170                 175     


Phe Lys Asn Thr Lys Leu His Val Leu Leu Glu Lys Leu Thr Glu Val 
            180                 185                 190         


Tyr Gly Ser Gly His Arg Leu Val His Tyr Ile Ala Pro Ser Met Ala 
        195                 200                 205             


Thr Val Glu Pro Thr Ile Asp Phe Leu Thr Leu Gly Ala Leu Lys Lys 
    210                 215                 220                 


Ser Arg Asn Ala Arg Arg Val Thr Gly Ile Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys His 
            


<210>  164
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  164

Gly Ser Leu Phe Ile Val Gly Ser Gly Ile Arg Ser Ile Ala Gln Leu 
1               5                   10                  15      


Thr Leu Glu Ala Ile Met His Ile Glu Asn Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Val Val Cys Asp Pro Val Thr Glu Gly Phe Ile Lys Glu Lys Asn Pro 
        35                  40                  45              


Asn Ala Val Asp Leu Tyr Glu Tyr Tyr Ser Asn Thr Lys Leu Arg Asn 
    50                  55                  60                  


Glu Thr Tyr Ile Gln Met Ala Glu Ile Met Leu Arg Glu Val Arg Ser 
65                  70                  75                  80  


Gly Leu Arg Val Val Gly Val Phe Tyr Gly His Pro Gly Asn Phe Val 
                85                  90                  95      


Ser Pro Thr Arg Arg Ala Leu Ala Ile Ala Arg Asp Glu Gly Tyr Val 
            100                 105                 110         


Ala Lys Met Leu Pro Gly Ile Ser Ala Asp Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Leu Ile Asp Pro Cys Tyr Pro Gly Leu Gln Thr Val Glu Ala Thr 
    130                 135                 140                 


Asp Val Leu Val Arg Asn Arg Pro Leu Gln Thr Thr Ser His Val Val 
145                 150                 155                 160 


Ile Tyr Gln Val Gly Val Ile Cys Lys Ser Gly Phe Asp Phe Tyr Ser 
                165                 170                 175     


Ile Glu Asn Asp Lys Phe Asp His Phe Val Thr Arg Leu Gln Glu Asp 
            180                 185                 190         


Tyr Gly Pro Asn His Pro Val Val Asn Tyr Val Ala Ala Val Ser Pro 
        195                 200                 205             


Leu Ala Glu Pro Thr Ile Gln Arg His Thr Ile Ser Glu Leu Phe Lys 
    210                 215                 220                 


Asp Ser Val Lys Ala Ser Ile Ser Gly Val Ser Thr Phe Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys Glu 
            


<210>  165
<211>  243
<212>  PRT
<213>  Bacterial alpha-N-methyltransferase domain shown in FIG. 2A

<400>  165

Gly Lys Leu Val Ile Val Gly Ser Gly Ile Arg Ser Ile Ser Gln Phe 
1               5                   10                  15      


Thr Leu Glu Ala Val Ala His Ile Glu His Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Gly Thr Asp Ala Phe Ile Glu Arg His Asn Lys 
        35                  40                  45              


Asn Ala Val Asp Leu Tyr Asn Leu Tyr Gly Asp Gly Lys Pro Arg His 
    50                  55                  60                  


Gln Thr Tyr Thr Gln Met Ala Glu Val Ile Leu Gln Glu Val Arg Lys 
65                  70                  75                  80  


Gly Phe Ser Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ala His Arg Ala Val Ser Ile Ala Ala Ser Glu Gly Tyr Glu 
            100                 105                 110         


Ala Thr Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Leu Ile Asp Pro Ser Arg Pro Gly Cys Gln Thr Leu Glu Ala Thr 
    130                 135                 140                 


Asp Val Leu Leu Arg Lys Arg Pro Ile Ala Lys Asp Cys His Val Ile 
145                 150                 155                 160 


Ile Phe Gln Val Gly Ala Val Gly Asp Leu Gly Phe Asn Phe Lys Gly 
                165                 170                 175     


Phe Lys Asn Thr Lys Phe Glu Ile Leu Val Gln His Leu Leu Glu Val 
            180                 185                 190         


Tyr Gly Pro Asp His Ser Val Val His Tyr Ile Ala Ser Gln Leu Thr 
        195                 200                 205             


Phe Ala Ala Pro Ile Arg Asp Arg Tyr Ala Ile Gln Asp Leu Val Lys 
    210                 215                 220                 


Pro Glu Val Ala Lys Arg Ile Thr Gly Ile Ser Thr Phe Tyr Leu Pro 
225                 230                 235                 240 


Pro Lys Asp 
            


<210>  166
<211>  203
<212>  PRT
<213>  Archaeal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  166

Met Asp Lys Leu Tyr Glu Asp Arg Ile Glu Glu Met Gly Thr Glu Gln 
1               5                   10                  15      


Tyr Asp Leu Arg Asn His Tyr Thr Glu Gln Glu Asp Arg Ala Glu Thr 
            20                  25                  30          


Tyr Glu Lys Met Ala Glu Thr Val Leu Gln Ala Ala Glu Glu Val Asp 
        35                  40                  45              


Glu Pro Val Thr Leu Gly Leu Tyr Gly His Pro Met Val Phe Val Ser 
    50                  55                  60                  


Pro Ser Gln Lys Val Ile Asn Arg Ala Glu Glu Arg Gly Met Met Val 
65                  70                  75                  80  


Glu Val Arg Pro Gly Ile Ser Ser Met Asp Cys Leu Tyr Val Asp Leu 
                85                  90                  95      


Glu Phe Asp Pro Gly Arg Ser Gly Val Gln Met Phe Glu Ala Thr Asp 
            100                 105                 110         


Leu Met Leu Arg Glu Trp Glu Leu Asn Pro Glu Val Pro Ala Met Ile 
        115                 120                 125             


Trp Gln Ile Gly Gly Val Glu Ser Thr Ile His His Glu Ser Val Glu 
    130                 135                 140                 


Asp Lys Pro Glu Arg Tyr Ser Arg Ile Arg Glu Tyr Leu Gln Gln Phe 
145                 150                 155                 160 


Tyr Pro Asp Asp His Thr Val Val Ser Ala Lys Thr Pro Ile Tyr Pro 
                165                 170                 175     


Thr Thr Glu Pro Gln Gln Tyr Glu Phe Gln Leu Asp Glu Phe Glu Ser 
            180                 185                 190         


Met Ala Asp Ser Ile Asp His Leu Gln Thr Leu 
        195                 200             


<210>  167
<211>  240
<212>  PRT
<213>  Archaeal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  167

Asp Ile Tyr Val Ile Gly Thr Gly Met Val Gly Thr Arg Gln Phe Thr 
1               5                   10                  15      


Gln Glu Ala Ile Ser Ala Leu Glu Gln Cys Glu Arg Val Tyr Leu Val 
            20                  25                  30          


His Phe Gln Lys Ser Val Lys Lys Tyr Leu Glu Glu Phe Thr Asp Gln 
        35                  40                  45              


Val His Val Leu Thr Asp Glu Tyr Asn Glu Gly Glu Lys Arg Asp Asn 
    50                  55                  60                  


Thr Tyr Ala Arg Met Ala Gln Gln Val Leu Asp Gly Ala Glu Glu Ser 
65                  70                  75                  80  


Glu Gly Pro Val Val Phe Ala Leu Tyr Gly His Pro Met Val Phe Val 
                85                  90                  95      


Ser Pro Ser Arg Trp Val Ile Asp Glu Ala Pro Glu Arg Gly Leu Glu 
            100                 105                 110         


Val Glu Val Gln Pro Gly Ile Ser Ser Met Asp Cys Leu Tyr Ser Asp 
        115                 120                 125             


Ile Ala Phe Asp Pro Ala Lys Asn Gly Val Gln Met Phe Glu Ala Ser 
    130                 135                 140                 


Asp Leu Leu Leu Arg Glu Phe Asp Leu Asn Pro Asp Ile Pro Ala Met 
145                 150                 155                 160 


Ile Trp Gln Val Gly Met Leu Glu Ser Ala Leu Tyr Thr Thr Asn Ser 
                165                 170                 175     


Ser Glu Pro Glu Arg Phe Thr Arg Phe Arg Glu Tyr Leu Glu Arg Phe 
            180                 185                 190         


Tyr Pro Pro Asp His Ser Val Ser Leu Leu Gln Thr Ala Thr Tyr Pro 
        195                 200                 205             


Ile Ser Asn Ser Arg Gln Ile Glu Phe Glu Ile Lys Asp Phe Glu Lys 
    210                 215                 220                 


Met Ala Asp Glu Ile Asn Ala Ile Gln Thr Leu Tyr Ile Pro Pro Ala 
225                 230                 235                 240 


<210>  168
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  168

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Gln Leu Ala Gly Gln Ile 
1               5                   10                  15      


Ser Val Leu Ser Arg Ser Tyr Ile Glu His Ala Asp Ile Val Phe Ser 
            20                  25                  30          


Leu Leu Pro Asp Gly Phe Ser Gln Arg Trp Leu Thr Lys Leu Asn Pro 
        35                  40                  45              


Asn Val Ile Asn Leu Gln Gln Phe Tyr Ala Gln Asn Gly Glu Val Lys 
    50                  55                  60                  


Asn Arg Arg Asp Thr Tyr Glu Gln Met Val Asn Ala Ile Leu Asp Ala 
65                  70                  75                  80  


Val Arg Ala Gly Lys Lys Thr Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Met Ala Ile Thr Arg Ala Lys Ala Glu 
            100                 105                 110         


Gly Phe Ser Ala Lys Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly Asn Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Phe Asn His Val Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Ile Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Gln Phe His Thr Ser Ser Asp Arg Leu Gln Ile Leu Val Glu Gln Leu 
            180                 185                 190         


Asn Gln Trp Tyr Pro Leu Asp His Glu Val Val Ile Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Ile Gln Ala Pro Arg Ile Glu Arg Leu Pro Leu Ala Asn 
    210                 215                 220                 


Leu Pro Gln Ala His Leu Met Pro Ile Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  169
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  169

Gly Ser Leu Gln Val Val Gly Ser Gly Ile Leu Pro Ile Ser Asp Met 
1               5                   10                  15      


Ser Leu Gly Ala Gln Ala Gln Ile Met Ala Ala Asp Ile Val Leu Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Ala Thr Glu Leu Arg Ile His Glu Leu Asn Pro 
        35                  40                  45              


Arg Ser Thr Ser Leu Tyr Gly Leu Tyr Gly Asn Gly Val Pro Arg Ile 
    50                  55                  60                  


Glu Thr Tyr Arg Ala Met Val Asp Ala Met Leu Glu Gln Val Arg Arg 
65                  70                  75                  80  


Gly Arg Arg Thr Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Trp Ser Thr His Glu Ala Ile Arg Arg Ala Arg Ser Glu Gly Tyr Arg 
            100                 105                 110         


Ala Glu Met Gly Ser Ala Val Ser Ala Gln Asp Ser Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Leu Asp Pro Ser Ser Phe Gly Leu Met Thr Leu Asp Ala Thr 
    130                 135                 140                 


Asp Phe Leu Ile Arg Asn Arg Ser Leu Asp Pro Ser Met His Val Leu 
145                 150                 155                 160 


Leu Trp Gln Ala Glu Cys Ala Gly Asp Asp Gly Phe Asn Phe Ala Gly 
                165                 170                 175     


Tyr Arg Arg His Asn Phe Pro Ile Leu Ile Glu Arg Val Ser Gly Phe 
            180                 185                 190         


Tyr Pro Pro Asp His Pro Val Val Ile Tyr Asp Ala Ser Thr Phe Gly 
        195                 200                 205             


His Leu Pro Pro Val Ile Gln Leu Lys Arg Leu Asp Thr Ile Lys Ala 
    210                 215                 220                 


Ser Asp Leu Ser Gly Ile Ser Thr Leu Tyr Leu Pro Pro Ala 
225                 230                 235             


<210>  170
<211>  240
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  170

Gly Arg Leu Val Val Val Gly Ser Gly Ile Arg Pro Ile Thr Asp Leu 
1               5                   10                  15      


Ser Met Gly Ala Arg Asp Gln Ile Val Ala Ala Asp Val Val Val Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Val Thr Glu Leu Tyr Leu His Glu Leu Asn Pro 
        35                  40                  45              


Asn Ala His Ser Leu Tyr Gly Leu Tyr Gly Asn Ala Lys Pro Arg Ile 
    50                  55                  60                  


Glu Thr Tyr Lys Glu Met Val Glu Ala Met Leu Ala Pro Val Arg Glu 
65                  70                  75                  80  


Gly Leu Arg Val Cys Ala Val Phe Tyr Gly His Pro Gly Ile Phe Ala 
                85                  90                  95      


Trp Ala Thr His Glu Ala Ile Arg Arg Ala Arg Asp Ala Gly Leu Arg 
            100                 105                 110         


Ala Glu Met Ala Pro Ala Ile Ser Ser Gln Asp Ser Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Ser Ala Gly Leu Gln Thr Val Asp Ala Thr 
    130                 135                 140                 


Asp Leu Leu Ile Arg Gly Arg Glu Leu Asn Pro Ser Met His Val Leu 
145                 150                 155                 160 


Val Trp Gln Pro Glu Cys Val Gly Asp Asp Gly Phe Asn Phe Ala Gly 
                165                 170                 175     


Tyr Glu Arg His Asn Phe Pro Val Leu Val Glu Tyr Leu Arg Arg Thr 
            180                 185                 190         


Tyr Ala Gly Asp His Thr Val Val Ile Tyr Asp Ala Ser Thr Tyr Pro 
        195                 200                 205             


His Leu Pro Pro Ser Ser Ala Arg Arg Arg Ser Thr Arg Ser Leu Pro 
    210                 215                 220                 


Gly Thr Ser Pro Gly Ser Arg Arg Ser Thr Cys Pro Arg Pro Ser Pro 
225                 230                 235                 240 


<210>  171
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  171

Gly Arg Leu Val Val Val Gly Ser Gly Ile Arg Pro Ile Ser Asp Leu 
1               5                   10                  15      


Thr Leu Gly Ala Arg Asp Gln Ile Ile Ala Ala Asp Val Val Val Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Ile Thr Glu Leu Gln Ile His Glu Leu Asn Pro 
        35                  40                  45              


Asn Ala His Ser Leu Tyr Gly Leu Tyr Gly Asn Gly Lys Pro Arg Ile 
    50                  55                  60                  


Asp Thr Tyr Arg Glu Met Val Glu Ala Met Leu Thr Pro Leu Arg Glu 
65                  70                  75                  80  


Gly Lys Arg Val Cys Ala Val Phe Tyr Gly His Pro Gly Ile Phe Ala 
                85                  90                  95      


Trp Ala Thr His Glu Ser Ile Arg Gln Ala Arg Ala Ala Gly Leu Arg 
            100                 105                 110         


Ala Glu Met Ala Pro Ala Ile Ser Ser Gln Asp Ser Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Ser Ala Gly Leu Gln Thr Val Asp Ala Thr 
    130                 135                 140                 


Asp Leu Leu Ile Arg Arg Arg Gln Leu Asn Pro Thr Met His Val Leu 
145                 150                 155                 160 


Ile Trp Gln Ala Glu Cys Val Gly Asp Asp Gly Phe Asn Phe Ala Gly 
                165                 170                 175     


Tyr Glu Arg His Asn Phe Pro Ile Leu Ile Glu Tyr Leu Gln Gln Thr 
            180                 185                 190         


Tyr Pro Ser Asp His Thr Val Val Ile Tyr Asp Ala Ser Thr Tyr Pro 
        195                 200                 205             


His Leu Pro Pro Thr Ile Arg Ser Thr Thr Leu Asp Val Val Asp Ala 
    210                 215                 220                 


Gln Asp Leu Ser Gly Ile Ser Thr Leu Tyr Leu Pro Pro Ala 
225                 230                 235             


<210>  172
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  172

Gly Gln Leu Val Ile Val Gly Ser Gly Ile Arg Ala Ile Ala Asp Leu 
1               5                   10                  15      


Thr Phe Asp Ala Glu Ala Gln Ile Arg Thr Ala Gln Lys Val Leu Tyr 
            20                  25                  30          


Cys Val Ala Asp Pro Val Ile Glu Arg Arg Leu His Leu Leu Asn Ser 
        35                  40                  45              


Thr Ala Glu Ser Leu Tyr Gly Leu Tyr Gly Asn Asn Lys Pro Arg Ile 
    50                  55                  60                  


Glu Thr Tyr His Ala Met Val Asp Ala Leu Leu Ala Pro Val Arg Ala 
65                  70                  75                  80  


Gly Leu Arg Val Cys Gly Val Phe Tyr Gly His Pro Gly Ser Phe Ala 
                85                  90                  95      


Trp Pro Thr His Gln Ala Ile Arg Val Ala Arg Arg Asp Gly Phe Lys 
            100                 105                 110         


Ala Glu Met His Ala Ser Val Ser Ala Asp Ala Ser Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Gln Pro Gly Cys His Ser Leu Glu Ala Thr 
    130                 135                 140                 


Glu Phe Leu Ile His Arg Arg Val Pro Asp Thr Ser Ser His Leu Leu 
145                 150                 155                 160 


Val Trp Gln Ala Glu Cys Val Gly Asp Pro Gly Phe Asn Phe Ala Gly 
                165                 170                 175     


Tyr Lys Arg His Asn Phe Asp Ile Leu Ile Asn Gln Leu Gln Lys Phe 
            180                 185                 190         


Tyr Pro Ala Asp His Pro Val Phe Ile Tyr Glu Ala Ala Ser Leu Pro 
        195                 200                 205             


Gln Gly Arg Pro Lys Ile Ile Lys Ser Thr Leu Asp Thr Ile Arg Lys 
    210                 215                 220                 


Glu Asp Leu Thr Gly Ile Ser Thr Leu Tyr Leu Pro Pro Ser 
225                 230                 235             


<210>  173
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  173

Gly Ser Leu Val Cys Val Gly Thr Gly Met Met Val Gly Ala His Leu 
1               5                   10                  15      


Ser Pro Ile Cys Gln Ser His Ile Glu Gln Ala Asp Val Val Phe Val 
            20                  25                  30          


Cys Val Ala Glu His Tyr Met Glu Ala Trp Ile Thr Ser Leu Asn Lys 
        35                  40                  45              


Asn Thr Val Asn Leu Gln Thr Phe Tyr Gly Glu Gly Lys Asp Arg His 
    50                  55                  60                  


Asp Thr Tyr Ala Gln Met Thr Ser Ala Met Leu Glu Arg Val Glu Lys 
65                  70                  75                  80  


Gly Glu Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Lys Val Pro His Asp Ala Ile Ala Ile Ala Lys Ser Arg Gly Phe Asp 
            100                 105                 110         


Ala Tyr Met Leu Pro Gly Ile Ser Ala Glu Ser Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Ala Leu Gly Cys Gln His Tyr Glu Ala Asn 
    130                 135                 140                 


Gln Phe Leu Leu Tyr Lys Arg Glu Val Asp Thr Ala Ala Tyr Leu Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Val Ala Gly Asp Phe Ser Ser Ala Val Phe Thr 
                165                 170                 175     


Ser Ser Ser Leu Gln Arg Lys Lys Leu Thr Asp Lys Leu Leu Ser Ile 
            180                 185                 190         


Tyr Gln Ala Asn Asp Ser Ala Ile Leu Tyr Glu Ala Ala Thr Leu Pro 
        195                 200                 205             


Ile Asp Glu Phe Arg Ala Thr Thr Ile Ala Ile Gly Glu Leu His Asn 
    210                 215                 220                 


His Glu Ile Asn Gln His Ser Thr Leu Val Ile Pro Pro Val 
225                 230                 235             


<210>  174
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  174

Gly Ser Ile Ala Cys Val Gly Met Gly Ile Thr Leu Gly Ser His Leu 
1               5                   10                  15      


Thr Pro Leu Ser Arg Ser His Ile Glu Gln Ala Asp Val Val Phe Ala 
            20                  25                  30          


Ala Leu Ser Asp His Val Val Glu Leu Trp Leu Lys Arg Leu Asn Pro 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Tyr Tyr Lys Pro Gly Lys Ser Arg Met 
    50                  55                  60                  


Arg Thr Tyr Arg Glu Trp Val Gln Leu Met Ile Ala Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Ser Val Cys Ala Val Phe Tyr Gly His Pro Gly Ile Phe Ala 
                85                  90                  95      


Trp Ser Thr His Lys Val Val Glu Leu Ala Arg Ala Glu Gly Tyr Lys 
            100                 105                 110         


Ala His Met Glu Ala Gly Ile Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Arg Val Gly Cys Gln His Leu Glu Ala Ser 
    130                 135                 140                 


Gln Leu Leu Phe Phe Glu Arg Asn Leu Asp Thr Thr Ser His Val Ile 
145                 150                 155                 160 


Leu Trp Gln Leu Gly Val Val Gly Asp Arg Ser Leu Gly Arg Phe Arg 
                165                 170                 175     


Thr Pro Asp Ala Tyr Arg Glu Leu Leu Val Glu Arg Leu Arg Asp Asp 
            180                 185                 190         


Tyr Ala Glu Asp His Glu Val Ile Val Tyr Arg Ala Pro Thr Leu Pro 
        195                 200                 205             


Ile Glu Ser Ala His Ile Gln Arg Met Pro Leu Lys Asp Phe Val Asn 
    210                 215                 220                 


Ala Gln Phe Thr Gly Gln Glu Thr Leu Val Leu Pro Pro Ala 
225                 230                 235             


<210>  175
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  175

Gly Ser Leu Val Cys Val Gly Leu Gly Met Thr Leu Gly Ser His Leu 
1               5                   10                  15      


Gly Pro Leu Ala Arg Ser His Ile Glu Gln Ala Asp Val Val Phe Ala 
            20                  25                  30          


Gly Leu Ser Asp Gly Ile Val Glu Leu Trp Leu Asn Lys Met His Ala 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Tyr Tyr Glu Glu Gly Lys Ser Arg Met 
    50                  55                  60                  


Leu Thr Tyr Arg Gln Met Val Glu Ala Ile Leu Ala Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Arg Val Cys Gly Val Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Trp Ala Pro His Lys Ser Ile Glu Ile Ala Arg Ser Glu Gly Tyr Ser 
            100                 105                 110         


Ala His Met Glu Pro Gly Ile Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Arg Phe Gly Cys Gln His Tyr Glu Ala Ser 
    130                 135                 140                 


Gln Leu Leu Phe Tyr Gln Arg Arg Ile Asp Pro Thr Ala Tyr Leu Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Leu Val Gly Asp Gln Ser Leu Ala Arg Phe Ser 
                165                 170                 175     


Thr Gly Pro Ala Tyr Arg Gln Val Leu Val Asp Val Leu Ala Arg Asp 
            180                 185                 190         


Tyr Pro Leu Asp His Glu Leu Ile Ile Tyr Arg Ser Ala Thr Leu Pro 
        195                 200                 205             


Ile Gln Gln Pro Arg Ile Glu Arg Met Ala Leu Gly Asp Leu Pro Gln 
    210                 215                 220                 


Ala Asp Ile Gly Val Pro Asp Thr Val Val Val Pro Pro Ala 
225                 230                 235             


<210>  176
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  176

Gly Ser Leu Ala Cys Val Gly Ile Gly Met Thr Leu Gly Ala His Ile 
1               5                   10                  15      


Cys Pro Leu Ser Lys Ser Tyr Ile Glu Gln Ala Asp Val Val Phe Ser 
            20                  25                  30          


Ala Val Ser His Gly Ile Thr Glu Leu Trp Leu Gln Glu Met His Ser 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Glu Tyr Tyr Gln Glu Gly Lys Ser Arg Leu 
    50                  55                  60                  


Ile Thr Tyr Asn Glu Met Val Asp Ala Met Met Thr Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Gln Ala Pro His Lys Ser Ile Ala Met Ala Lys Ala Glu Gly Phe Ala 
            100                 105                 110         


Ala Lys Met Ile Pro Gly Ile Ser Ala Glu Asp Cys Leu Ile Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Arg Phe Gly Cys Gln Gln Phe Glu Ala Ser 
    130                 135                 140                 


Gln Phe Met Phe Tyr Lys Arg Gln Tyr Asp Pro Ser Cys Tyr Leu Ile 
145                 150                 155                 160 


Leu Trp Gln Ile Gly Leu Ala Gly Asp Arg Ser Leu Ala Lys Phe Ser 
                165                 170                 175     


Thr Gly Ala Ala His Arg Gln Val Leu Ile Glu Leu Leu Ser Glu Val 
            180                 185                 190         


Tyr Pro Leu Asp His Gln Val Ile Leu Tyr Glu Ala Ala Val Leu Pro 
        195                 200                 205             


Ile Asp Asn Ile Arg Ile Glu Thr Leu Ser Leu Ser Glu Leu Val Thr 
    210                 215                 220                 


Ala Glu Ile His Met His Thr Thr Leu Val Ile Pro Pro Ser 
225                 230                 235             


<210>  177
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  177

Gly Ser Leu Ala Cys Val Gly Ile Gly Met Thr Leu Gly Ala His Ile 
1               5                   10                  15      


Cys Pro Leu Ala Lys Ser Tyr Ile Glu Gln Ala Asp Val Val Phe Ser 
            20                  25                  30          


Gly Val Ser Asn Gly Ile Val Glu Leu Trp Leu Gln Glu Met His Ser 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Val Tyr Tyr Lys Glu Gly Lys Ser Arg His 
    50                  55                  60                  


Ile Thr Tyr Arg Glu Met Val Asp Ala Ile Leu Thr Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


His Ala Pro His Lys Ser Ile Glu Leu Ala Lys Ala Glu Gly Phe Asp 
            100                 105                 110         


Ala Val Met Val Pro Gly Ile Ser Ala Glu Asp Cys Leu Ile Ala Asp 
        115                 120                 125             


Leu Ala Ile Asp Pro Gly Lys Phe Gly Cys Gln Gln Phe Glu Ala Ser 
    130                 135                 140                 


Gln Phe Met Phe Tyr Lys Arg Arg Phe Asp Pro Ser Ser Tyr Leu Val 
145                 150                 155                 160 


Leu Trp Gln Ile Gly Leu Ala Gly Asp Lys Ser Met Ala Lys Phe Ala 
                165                 170                 175     


Thr Gly Ala Ala His Arg Gln Val Leu Ile Glu Leu Leu Ser Thr Glu 
            180                 185                 190         


Tyr Pro Leu Asp His Gln Val Ile Leu Tyr Glu Ala Ala Val Leu Pro 
        195                 200                 205             


Ile Asp Thr Val Arg Lys Gln Thr Leu Thr Leu Ala Glu Leu Ala Asp 
    210                 215                 220                 


Ala Asp Ile Tyr Met His Thr Thr Leu Val Ile Pro Pro Ser 
225                 230                 235             


<210>  178
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  178

Gly Ser Leu Val Cys Val Gly Val Gly Met Thr Met Gly Ser His Leu 
1               5                   10                  15      


Thr Pro Leu Ser Arg Asn Tyr Ile Glu Thr Ala Asp Val Val Phe Ser 
            20                  25                  30          


Leu Met Ser Asp Gly Ile Val Glu Gln Trp Val Glu Thr Met Asn Pro 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Phe Tyr Gln Glu Gly Thr Ser Arg Leu 
    50                  55                  60                  


Ile Ser Tyr Gln Asn Met Ile Asn Ala Val Leu Asp Glu Val Arg Gln 
65                  70                  75                  80  


Gly Lys Asn Val Val Gly Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Met Val Thr His Lys Leu Ile Ala Gln Ser Lys Lys Glu Gly Phe Tyr 
            100                 105                 110         


Cys His Met Glu Ala Gly Ile Ser Ala Glu Asp Cys Leu Ile Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Arg Leu Gly Cys Gln Gln Tyr Glu Ala Ser 
    130                 135                 140                 


Gln Phe Met Phe Tyr Arg Arg Thr Ile Asp Thr Ala Ala Tyr Leu Ile 
145                 150                 155                 160 


Leu Trp Gln Pro Gly Ile Ala Gly Asp Gln Ser Leu Ala Arg Phe Ala 
                165                 170                 175     


Thr Ala Glu Ser Phe Arg Ala Val Leu Val Glu Leu Leu Cys Glu Tyr 
            180                 185                 190         


Tyr Ala Lys Asp His Gln Val Ile Leu Tyr Glu Ala Lys Thr Leu Ala 
        195                 200                 205             


Phe Asn Asn Pro Arg Ile Asp Thr Leu Pro Leu Gly Glu Leu Ala Lys 
    210                 215                 220                 


Ala Thr Ile His Leu His Thr Thr Leu Val Ile Pro Pro Ser 
225                 230                 235             


<210>  179
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  179

Gly Asn Leu Val Cys Val Gly Thr Gly Ile Leu Leu Gly Gly His Leu 
1               5                   10                  15      


Ser Pro Leu Ala Gln Asn Leu Ile Glu Gln Ala Asp Val Val Phe Ser 
            20                  25                  30          


Gly Met Ser Asp Gly Phe Thr Glu Leu Trp Ile Glu Gly Leu Ala Lys 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Gln His Tyr Ala Asp Gly Lys Ser Arg Asn 
    50                  55                  60                  


Leu Thr Tyr Asn Glu Met Val Asp Ala Met Leu Cys Glu Val Arg Leu 
65                  70                  75                  80  


Gly Lys Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Ile Phe Ala 
                85                  90                  95      


Lys Ala Pro His Glu Ala Ile Ala Thr Ala Arg Ala Glu Gly Phe Glu 
            100                 105                 110         


Ala Arg Met Ile Pro Gly Ile Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Leu Asp Pro Gly Lys Thr Gly Cys Gln His Phe Glu Thr Thr 
    130                 135                 140                 


Gln Leu Met Leu Tyr Gln Arg Arg Ile Asp Pro Ser Ala Leu Leu Val 
145                 150                 155                 160 


Leu Trp Gln Pro Ala Leu Ala Gly Asp Leu Thr Leu Gly Ile Arg Pro 
                165                 170                 175     


Thr Gly Ser Ala Glu Arg Glu Leu Leu Val Glu Leu Leu Ser Gln Asp 
            180                 185                 190         


Tyr Pro Leu Asn His Glu Cys Ile Leu Tyr Glu Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu His Ser Thr Arg Ile Glu Arg Leu Pro Leu Ser Ala Leu Pro Gln 
    210                 215                 220                 


Ala Arg Leu Glu Leu His Thr Thr Leu Val Leu Pro Pro Ser 
225                 230                 235             


<210>  180
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  180

Gly Ser Leu Thr Cys Val Gly Val Gly Met Met Leu Gly Gly His Leu 
1               5                   10                  15      


Ser Pro Ile Ala His Ser His Ile Thr Gln Ala Asp Val Val Phe Ser 
            20                  25                  30          


Gly Val Ser Asp Gly Phe Val Glu Gln Trp Leu Ser Gly Leu Asn Ala 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Val His Tyr Gly Glu Gly Lys Ser Arg Asn 
    50                  55                  60                  


Ile Ser Tyr Gly Glu Met Val Gln Val Met Leu Ala Glu Val Arg Leu 
65                  70                  75                  80  


Gly Lys Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


Lys Ser Thr His Glu Ala Ile Ala Lys Ala Lys Glu Glu Gly Phe Ala 
            100                 105                 110         


Ala Lys Met Ile Pro Gly Ile Ser Ala Glu Ser Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Lys Val Gly Cys Gln His Phe Glu Thr Thr 
    130                 135                 140                 


Gln Phe Met Leu Tyr His Arg Gln Leu Asp Pro Ser Ala His Leu Ile 
145                 150                 155                 160 


Leu Trp Gln Pro Gly Leu Ala Gly Asp Leu Thr Tyr Gly Ile Lys Pro 
                165                 170                 175     


Thr Gly Arg Ala Glu Arg Gln Leu Leu Val Glu Leu Leu Ser Lys Asp 
            180                 185                 190         


Tyr Pro Leu Glu His Glu Cys Ile Leu Tyr Glu Ala Ala Thr Met Pro 
        195                 200                 205             


Leu Gln Ser Gly Arg Ile Glu Arg Leu Pro Leu Asn His Leu Pro Leu 
    210                 215                 220                 


Ala Gln Ile Ala Leu His Thr Thr Leu Val Leu Pro Pro Ser 
225                 230                 235             


<210>  181
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  181

Gly Ser Ile Thr Cys Val Gly Val Gly Met Met Leu Gly Ala His Leu 
1               5                   10                  15      


Ser Pro Val Ser Leu Ser His Ile Glu Gln Ala Asp Ile Val Phe Cys 
            20                  25                  30          


Gly Val Ser Asp Pro Leu Val Glu Leu Trp Leu Lys Glu Leu Asn Ala 
        35                  40                  45              


Asn Val Arg Ser Leu Gln Pro Cys Tyr Ala His Gly Lys Ser Arg His 
    50                  55                  60                  


Leu Ser Tyr Arg Glu Met Val Asp Thr Met Leu Ser Glu Val Arg Leu 
65                  70                  75                  80  


Gly Lys Lys Val Val Gly Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Lys Ala Pro His Gln Ala Val Thr Ile Ala Arg Asn Glu Gly Phe Glu 
            100                 105                 110         


Ala Gln Met Leu Pro Gly Ile Ser Ala Ala Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Gly Gln Asn Gly Cys Gln His Phe Glu Ala Thr 
    130                 135                 140                 


Gln Phe Met Leu Tyr His Arg Arg Val Asp Pro Thr Ala Thr Leu Ile 
145                 150                 155                 160 


Leu Trp Gln Ile Gly Leu Ala Gly Asp Leu Asp Met Gly Leu Thr Ile 
                165                 170                 175     


Thr Asp Ala Lys Asn Arg Gln Leu Leu Leu Glu Glu Leu Tyr Arg Leu 
            180                 185                 190         


Tyr Ser Pro Glu His Ser Cys Trp Leu Tyr Glu Ala Ala Thr Thr Ala 
        195                 200                 205             


Leu Ala Ser Pro Arg Arg Glu Ala Ile Lys Leu Arg Glu Leu Val Glu 
    210                 215                 220                 


Ala Thr Leu Ala Leu His Thr Thr Leu Val Ile Pro Pro Ala 
225                 230                 235             


<210>  182
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  182

Gly Asn Leu Val Cys Val Gly Thr Gly Leu Gln Leu Ala Gly Gln Ile 
1               5                   10                  15      


Gly Ala Leu Ser Leu Ser Tyr Ile Glu His Ala Asp Val Val Phe Ser 
            20                  25                  30          


Leu Val Pro Asp Gly Phe Ser Glu Arg Trp Leu Met Ser Leu Asn Cys 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Tyr Tyr Ala Gln His Asp Glu Val Lys 
    50                  55                  60                  


Asn Arg Arg Asp Thr Tyr Ala Glu Met Val Asp Ala Ile Leu Asp Glu 
65                  70                  75                  80  


Val Arg Leu Gly Lys Leu Val Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ala His Trp Ser Ile Lys Gln Ala Arg Ser Glu 
            100                 105                 110         


Gly Phe Asp Ala Ser Met Leu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly His Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Thr Gln Phe Met Leu Tyr His His Ile Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Leu Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Gln Phe Ser Ser Thr Lys Asp Lys Leu Gln Ile Leu Val Glu His Leu 
            180                 185                 190         


Asn Gln Trp Tyr Pro Leu Thr His Ala Val Ile Ile Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Phe Gln Ser Pro Val Ile Glu Arg Ile Pro Leu Ser Leu 
    210                 215                 220                 


Leu Pro Glu Ala Thr Leu Thr Thr Ile Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  183
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  183

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Gln Leu Ala Gly Gln Ile 
1               5                   10                  15      


Asn Val Met Ser Arg Ser Tyr Ile Glu His Ala Asp Ile Val Phe Ser 
            20                  25                  30          


Leu Leu Pro Asp Gly Phe Ser Gln His Trp Ile Gln Gln Ile Asn Pro 
        35                  40                  45              


Asn Val Ile Asn Leu Gln Gln Phe Tyr Ala Gln Asn Thr Glu Val Lys 
    50                  55                  60                  


Asn Arg Arg Asp Thr Tyr Val Glu Met Val Ala Ala Ile Leu Glu Ala 
65                  70                  75                  80  


Val Arg Ala Gly Lys Lys Thr Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Leu Ala Ile Arg Gln Ala Lys Ala Glu 
            100                 105                 110         


Gly Phe Ser Ala Lys Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly Asn Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Phe Asn His Val Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Ile Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Gln Phe His Thr Thr Thr Asp Arg Leu Gln Ile Leu Val Glu Gln Leu 
            180                 185                 190         


Ser Gln Trp Tyr Pro Met Asp His Gln Val Val Val Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Ile Gln Ala Pro Arg Val Asp Tyr Leu Leu Leu Ser Glu 
    210                 215                 220                 


Leu Pro Lys Ala His Leu Ser Pro Ile Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  184
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  184

Gly Thr Leu Val Cys Val Gly Thr Gly Leu Asn Leu Ala Gly Gln Ile 
1               5                   10                  15      


Ser Val Leu Ser Lys Ser Tyr Ile Glu His Ala Asp Val Val Phe Ser 
            20                  25                  30          


Leu Val Pro Asp Gly Phe Ala Gln His Trp Leu Glu Ser Leu Asn Gln 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Tyr Tyr Ala Gln Glu Gly Glu Val Lys 
    50                  55                  60                  


Ser Arg Arg Asp Thr Tyr Asp Gln Met Val Asp Ala Ile Leu Glu Gln 
65                  70                  75                  80  


Val Arg Leu Gly Lys Gln Val Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Phe Ala Ile Ala Gln Ala Arg Glu Glu 
            100                 105                 110         


Gly Tyr Ser Ala Gln Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Val Gly Ile Asp Pro Gly Ala Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Tyr Lys His Thr Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Gly Ile Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Glu Phe His Thr Ser Ser Asp Arg Leu Gln Val Leu Val Glu Gln Leu 
            180                 185                 190         


Ser Glu Trp Tyr Pro Leu Glu His Glu Ile Val Leu Tyr Glu Ala Pro 
        195                 200                 205             


Asn Leu Pro Thr Gln Ser Pro Arg Ile Glu Arg Val Ala Leu Lys Gln 
    210                 215                 220                 


Leu Pro Phe Ala Gln Leu Ser Ser Ile Thr Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  185
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  185

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Asn Leu Ala Gly Gln Ile 
1               5                   10                  15      


Ser Val Leu Ser Lys Ser Tyr Ile Glu Asn Ala Asp Val Val Phe Ser 
            20                  25                  30          


Leu Val Pro Asp Gly Phe Ala Gln Arg Trp Leu Glu Thr Leu Asn Ser 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Tyr Tyr Ala Gln Gly Asp Glu Ile Lys 
    50                  55                  60                  


Ser Arg Arg Asp Thr Tyr Asp Gln Met Val Gln Ala Ile Leu Asn Ala 
65                  70                  75                  80  


Val Arg Asp Gly Lys Lys Val Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Phe Ala Ile Glu Ile Ala Arg Glu Glu 
            100                 105                 110         


Gly Tyr Ile Ala Lys Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly Asn Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Tyr Lys His Thr Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Gly Ile Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Glu Phe His Thr Ser Ser Asp Arg Leu Gln Val Leu Val Glu Gln Leu 
            180                 185                 190         


Asn Gln Trp Tyr Pro Leu Glu His Glu Ile Ile Leu Tyr Glu Ala Pro 
        195                 200                 205             


Asn Leu Pro Ile Gln Gln Ala Arg Ile Asp Lys Leu Pro Leu Lys Asn 
    210                 215                 220                 


Leu Pro Phe Ala Arg Leu Thr Ala Ile Thr Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  186
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  186

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Asn Leu Ala Gly Gln Ile 
1               5                   10                  15      


Ser Val Leu Ser Lys Ser Tyr Ile Glu Asn Ala Asp Val Val Phe Ser 
            20                  25                  30          


Leu Val Pro Asp Gly Phe Ala Gln Arg Trp Leu Glu Thr Leu Asn Asn 
        35                  40                  45              


Asp Val Arg Ser Leu Gln Pro Phe Tyr Ala Gln Gly Asp Glu Ile Lys 
    50                  55                  60                  


Asn Arg Arg Asp Thr Tyr Asp Gln Met Val Glu Ala Ile Leu Glu Gln 
65                  70                  75                  80  


Val Arg Ala Gly Lys Arg Val Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Phe Ala Ile Ala Gln Ala Leu Asp Glu 
            100                 105                 110         


Gly Tyr Ser Ala Lys Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly Gln Ser Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Tyr Lys His Thr Pro Asp Pro Thr Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Gly Ile Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Glu Phe His Thr Ser Ser Asp Arg Leu Gln Ile Leu Val Glu Gln Leu 
            180                 185                 190         


Asn Glu Trp Tyr Pro Leu Glu His Glu Ile Thr Ile Tyr Glu Ala Pro 
        195                 200                 205             


Thr Leu Pro Ile His Gln Ala Arg Val Asp Lys Leu Leu Leu Arg Asp 
    210                 215                 220                 


Leu Pro Phe Ala Arg Leu Thr Ser Ile Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  187
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  187

Gly Ser Leu Val Phe Val Gly Thr Gly Leu Gln Leu Ala Gly Gln Ile 
1               5                   10                  15      


Ser Val Leu Ser Arg Ser Tyr Ile Glu Asn Ala Asp Arg Val Phe Ser 
            20                  25                  30          


Ile Val Pro Asp Ala Phe Ala Glu Glu Trp Leu Ile Ser Leu Asn Pro 
        35                  40                  45              


Asn His Thr Ser Leu Gln Ser Tyr Tyr Ala Gln Ala Asp Glu Val Lys 
    50                  55                  60                  


Asn Arg Arg His Thr Tyr Lys Gln Met Val Glu Ala Met Leu Val Ala 
65                  70                  75                  80  


Val Arg Lys Gly Glu Gln Val Val Cys Ala Leu Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Ser His Leu Ala Ile Ala Gln Ala Arg Thr Glu 
            100                 105                 110         


Gly Phe Asp Ser Tyr Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Leu Gly Ile Asp Pro Gly Gln Cys Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Thr Gln Phe Leu Leu Tyr Gln His Arg Pro Asp Pro Ser Thr 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Leu Ala Gly Asp His Thr Leu Thr 
                165                 170                 175     


Gln Phe Ser Thr Thr Ser Asp Arg Leu Gln Val Leu Val Asp Leu Leu 
            180                 185                 190         


Ser Gln Trp Tyr Pro Leu Asp His Glu Val Val Ile Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Leu Gln Gln Pro Arg Ile Glu Arg Leu Ala Leu Lys Ala 
    210                 215                 220                 


Leu Pro Gln Ala Arg Leu Thr Val Ile Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  188
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  188

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Lys Met Ala Gly His Ile 
1               5                   10                  15      


Ser Val Ile Ser Arg Ser Tyr Ile Glu His Ala Asp Lys Ile Phe Thr 
            20                  25                  30          


Leu Met Pro Asp Val His Thr Gln Gln Trp Ile Ala Arg Leu Asn Pro 
        35                  40                  45              


Ser Leu Val Asn Leu Gln Gln Phe Tyr Ala Gln Pro Gly Glu Val Lys 
    50                  55                  60                  


Ser Arg Arg Asp Thr Tyr His Gln Met Val Asp Thr Met Met Gln Ala 
65                  70                  75                  80  


Val Arg Ala Gly Glu Arg Val Val Gly Ala Phe Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Pro His Met Ala Ile Lys Gln Ala Arg Glu Glu 
            100                 105                 110         


Gly Phe Glu Ala His Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Met Gly Ile Asp Pro Gly Asp Tyr Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Phe Lys Arg Thr Pro Asp Pro Ala Ala 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Leu Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Gln Phe Ser Thr Thr Ser Glu Arg Leu Glu Ile Leu Val Gly Tyr Leu 
            180                 185                 190         


Gln Gln Trp Tyr Pro Ala Asp His Gln Val Ala Ile Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Val Gln Gln Pro Arg Ile Asp Trp Leu Glu Leu Gln Ala 
    210                 215                 220                 


Leu Pro Gly Thr Arg Leu Thr Ala Ala Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  189
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  189

Gly Ser Leu Val Cys Val Gly Thr Gly Leu Lys Met Ala Gly His Ile 
1               5                   10                  15      


Ser Val Ile Ser Arg Ser Tyr Ile Glu His Ala Asp Lys Ile Phe Thr 
            20                  25                  30          


Leu Met Pro Asp Val His Thr Gln Gln Trp Ile Ala Arg Leu Asn Pro 
        35                  40                  45              


Ser Leu Val Asn Leu Gln Gln Phe Tyr Ala Gln Pro Gly Glu Val Lys 
    50                  55                  60                  


Ser Arg Arg Asp Thr Tyr His Gln Met Val Asp Thr Met Met Gln Ala 
65                  70                  75                  80  


Val Arg Ala Gly Glu Arg Val Val Gly Ala Phe Tyr Gly His Pro Gly 
                85                  90                  95      


Val Phe Ala Cys Val Pro His Met Ala Ile Lys Gln Ala Arg Glu Glu 
            100                 105                 110         


Gly Phe Glu Ala His Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu 
        115                 120                 125             


Trp Ala Asp Met Gly Ile Asp Pro Gly Asp Tyr Gly His Gln Ser Phe 
    130                 135                 140                 


Glu Ala Ser Gln Phe Met Phe Phe Lys Arg Thr Pro Asp Pro Ala Ala 
145                 150                 155                 160 


His Leu Leu Leu Trp Gln Ile Ala Leu Ala Gly Glu His Thr Leu Thr 
                165                 170                 175     


Gln Phe Ser Thr Thr Ser Glu Arg Leu Glu Ile Leu Val Gly Tyr Leu 
            180                 185                 190         


Gln Gln Trp Tyr Pro Ala Asp His Gln Val Ala Ile Tyr Glu Ala Ala 
        195                 200                 205             


Asn Leu Pro Val Gln Gln Pro Arg Ile Asp Trp Leu Glu Leu Gln Ala 
    210                 215                 220                 


Leu Pro Gly Thr Arg Leu Thr Ala Ala Ser Thr Leu Leu Ile Pro Pro 
225                 230                 235                 240 


Ser 
    


<210>  190
<211>  237
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  190

Ala Gly Leu Val Val Val Gly Ser Gly Ile Asp Phe Gly Arg His Ala 
1               5                   10                  15      


Ser Glu Arg Cys Leu Ser Glu Ile Arg Glu Ala Glu Val Val Phe Cys 
            20                  25                  30          


Leu Val Asn Pro Val Ala Leu Ala Met Ile Cys Ser Phe Arg Pro Asp 
        35                  40                  45              


Ala Ile Asn Leu Gly Val His Tyr Ala Pro Gly Lys Asp Arg Arg Glu 
    50                  55                  60                  


Thr Tyr Arg Glu Ile Asp Asp Arg Ile Met Ala Glu Val Arg Ala Gly 
65                  70                  75                  80  


Arg Arg Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Asp 
                85                  90                  95      


Val Pro His Arg Val Val Arg Gln Ala Arg Ala Glu Gly Ile Pro Ala 
            100                 105                 110         


Arg Met Glu Pro Gly Ile Ser Ala Glu Ala Cys Leu Tyr Ala Asp Leu 
        115                 120                 125             


Gly Leu Asp Pro Gly Arg Arg Gly Val Gln Ser Met Glu Ala Thr His 
    130                 135                 140                 


Leu Met Val Tyr Asp Arg Gln Leu Asp Ser Ala Gly Leu Val Leu Leu 
145                 150                 155                 160 


Trp Gln Val Ala Leu Ala Gly Asp Leu Ser Cys Thr Arg Phe His Ala 
                165                 170                 175     


Glu Arg Asp Gly Leu Lys Ala Leu Val Asp Arg Leu Leu Cys Trp Tyr 
            180                 185                 190         


Pro Pro Glu His Glu Val Ile Leu Tyr Glu Ala Ala Trp Leu Pro Ile 
        195                 200                 205             


Glu Gln Pro Arg Ile Glu Arg Leu Ala Leu Arg Asp Leu Pro Asp Ala 
    210                 215                 220                 


Arg Tyr Ala Glu Tyr Thr Thr Leu Val Ile Pro Pro Leu 
225                 230                 235         


<210>  191
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  191

Gly Glu Leu Val Phe Val Gly Ser Gly Ile Lys Gly Thr His His Ile 
1               5                   10                  15      


Thr Pro Glu Thr Ser Leu His Ile Arg Thr Ala Gly Lys Val Leu Tyr 
            20                  25                  30          


Cys Val Ala Asp Val Ile Val Glu Arg Lys Ile Arg Leu Leu Asn Asn 
        35                  40                  45              


Asn Cys Glu Asp Leu Tyr Glu Leu Tyr Ala Asp Asp Lys Pro Arg Arg 
    50                  55                  60                  


Lys Thr Tyr Glu Glu Met Val Glu His Val Leu Glu Ala Leu Lys His 
65                  70                  75                  80  


Tyr Glu Lys Val Cys Val Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Trp Ser Ser Phe Thr Ala Ile Gln Lys Ala Arg Arg Asp Gly Ile Lys 
            100                 105                 110         


Ala Tyr Met Leu Pro Ala Val Ser Ser Leu Asp Cys Met Phe Ala Asp 
        115                 120                 125             


Ile Gly Phe Asp Pro Ser Arg Arg Gly Cys Gln Ile Phe Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Thr Arg Thr Arg Thr Pro Asp Thr Thr Ala Ala Val Ile 
145                 150                 155                 160 


Ile Leu Gln Leu Gly Ala Val Gly Asp Met Gly Phe Arg Phe Arg Gly 
                165                 170                 175     


Tyr Asp Arg Arg Asn Met Pro Val Phe Val Glu Tyr Leu Gln Asn Phe 
            180                 185                 190         


Tyr Gly Ala Asp His Glu Val Ile Leu Tyr Gln Ala Ala Gln Tyr Pro 
        195                 200                 205             


Val Cys Glu Pro Val Ile Gln Lys Val Ala Ile Arg Asp Ile Val Ala 
    210                 215                 220                 


Ala Lys Pro Thr Gly Ile Thr Thr Leu Tyr Ile Pro Pro Lys 
225                 230                 235             


<210>  192
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  192

Lys Glu Leu Val Phe Val Gly Thr Gly Ile Lys Gly Ala His His Leu 
1               5                   10                  15      


Thr Ala Glu Ala Ile Leu His Ile Glu Thr Ala Asp Lys Val Leu Tyr 
            20                  25                  30          


Cys Val Ala Asp Val Val Val Glu Arg Lys Ile Arg Gln Leu Asn Asp 
        35                  40                  45              


Asn Cys Arg Asp Leu Tyr Asp Leu Tyr Gly Asp Asp Lys Leu Arg Arg 
    50                  55                  60                  


Arg Thr Tyr Glu Glu Met Val Glu Cys Ser Met Asp Ala Leu Lys Glu 
65                  70                  75                  80  


Tyr Arg Lys Val Cys Val Val Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


Trp Pro Ser Phe Thr Ala Ile Arg Gln Ala Arg Gln Ala Gly Val Arg 
            100                 105                 110         


Ala Tyr Met Leu Pro Ala Val Ser Ser Ile Asp Cys Met Phe Ala Asp 
        115                 120                 125             


Leu Gly Phe Asp Pro Ser Arg His Gly Cys Gln Ile Leu Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Ser Arg Gly Lys Lys Pro Asp Val Asn Ala Ser Val Ile 
145                 150                 155                 160 


Ile Leu Gln Val Gly Ala Val Gly Asp Met Gly Phe Arg Phe Arg Gly 
                165                 170                 175     


Tyr Glu Lys Arg Asn Met Pro Ile Phe Val Glu Tyr Leu Ala Gly Phe 
            180                 185                 190         


Tyr Gly Pro Asp Tyr Glu Val Ile Leu Tyr Glu Ala Ser Gln Phe Pro 
        195                 200                 205             


Val Cys Ala Pro Thr Ile Arg Lys Leu Pro Ile Arg Asp Ile Thr Ala 
    210                 215                 220                 


Ala Asn Pro Ser Gly Ile Thr Ser Leu Tyr Ile Pro Pro Lys 
225                 230                 235             


<210>  193
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  193

Lys Glu Leu Val Phe Leu Gly Thr Gly Ile Arg Gly Ala Ser Gln Ile 
1               5                   10                  15      


Thr Pro Glu Ala Glu Tyr His Ile Arg Ser Ala Asp Lys Val Phe Tyr 
            20                  25                  30          


Cys Val Gly Asp Leu Val Ile Glu Arg Lys Ile Met Asn Leu Asn Ser 
        35                  40                  45              


Thr Ser Glu Asp Leu Tyr Pro Leu Tyr Gly Asp Glu Lys Pro Arg Arg 
    50                  55                  60                  


Glu Thr Tyr Glu Glu Met Val Ser Val Cys Tyr Gly Ala Leu Lys Val 
65                  70                  75                  80  


Asn Arg Lys Val Ala Val Ile Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


Tyr Ala Ser His Lys Ala Ile Arg Met Ala Arg Ala Glu Gly Ile Lys 
            100                 105                 110         


Ala Tyr Met Ala Pro Gly Ile Ser Ser Leu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Ile Gly Ile Asp Pro Ser Arg Phe Gly Cys Gln Ile Phe Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Val Lys Arg Arg Lys Pro Gly Ile Asp Thr Ala Val Ile 
145                 150                 155                 160 


Ile Met Gln Val Gly Cys Val Gly Asp Thr Gly Phe Arg Phe Lys Gly 
                165                 170                 175     


Tyr Glu Arg Arg Asn Met Pro Ile Leu Gln Glu Tyr Leu Ser Glu Ile 
            180                 185                 190         


Tyr Gly Asp Asn Tyr Glu Val Ile Leu Tyr Glu Ala Ala Ser Tyr Pro 
        195                 200                 205             


Glu Cys Glu Pro Arg Ile Arg Leu Ile Pro Leu Phe Asn Leu Val Glu 
    210                 215                 220                 


Ser Ser Pro Thr Gly Ile Thr Thr Met Tyr Ile Pro Pro Lys 
225                 230                 235             


<210>  194
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  194

Asn Glu Val Ile Phe Ile Gly Thr Gly Ile Lys Gly Ala Asn His Ile 
1               5                   10                  15      


Ser Ala Glu Ala Asp Ala Tyr Ile Ala Asn Ala Ser Lys Val Leu Tyr 
            20                  25                  30          


Cys Val Ala Asp Leu Ala Val Glu Arg Lys Ile Leu Leu Leu Asn Gln 
        35                  40                  45              


Asn Ser Glu Asp Leu Tyr Ile Tyr Tyr Gly Asp Asn Lys Pro Arg Arg 
    50                  55                  60                  


Glu Thr Tyr Glu Gln Met Val Asp Arg Ile Leu Glu Val Ile Lys Thr 
65                  70                  75                  80  


Glu Lys Leu Val Cys Val Val Phe Tyr Gly His Pro Gly Ile Phe Val 
                85                  90                  95      


Trp Pro Ser Tyr Gln Ala Ile Glu Lys Ala Arg Gly Met Gly Tyr Lys 
            100                 105                 110         


Ala Ser Met Leu Pro Ala Ile Ser Ser Leu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Ile Gly Phe Asp Pro Ser Arg Tyr Ser Cys Gln Ile Val Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Ile Arg Ser Arg Asn Leu Asp Val Ser Ala Ser Val Ile 
145                 150                 155                 160 


Ile Phe Gln Ile Gly Leu Val Gly Asp Leu Gly Tyr Ser Ser Lys Gly 
                165                 170                 175     


Phe Asp Gly Arg Asn Val Pro Ile Leu Ala Asp Tyr Leu Ser Ser Phe 
            180                 185                 190         


Tyr Gly Asp Asp Tyr Glu Val Ile Ile Tyr Glu Ala Ala Gln Tyr Pro 
        195                 200                 205             


Ile Phe Glu Pro Lys Ile Gln Leu Ile Lys Ile Asn Glu Leu Ser Lys 
    210                 215                 220                 


Ala Lys Leu Thr Gly Ile Ser Thr Met Tyr Ile Pro Pro Lys 
225                 230                 235             


<210>  195
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  195

Gly Ser Leu Thr Val Val Gly Thr Gly Ile Arg Leu Val Thr Gln Leu 
1               5                   10                  15      


Thr Pro Glu Ala Arg Ala Ala Ile Arg Asp Ala Glu Lys Val Phe Tyr 
            20                  25                  30          


Val Thr Asp Gly Pro Val Gln Arg Arg Trp Phe Glu Gln Leu Asn Ser 
        35                  40                  45              


Thr Ala Glu Ser Leu His His Leu Tyr Gln Leu Gly Arg Asp Arg Leu 
    50                  55                  60                  


Ser Thr Tyr Glu Glu Ile Val Glu Arg Ala Leu Ala Ala Ala Arg Gly 
65                  70                  75                  80  


Gly Val Arg Val Cys Leu Val Met Tyr Gly His Pro Gly Val Leu Val 
                85                  90                  95      


Thr Pro Ala His Asp Ala Ile Arg Ser Ala Arg Ala Glu Gly Leu Ser 
            100                 105                 110         


Ala Thr Met Leu Pro Gly Val Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Gly Ala Arg Gly Cys Gln Thr Phe Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Val Gln Arg Arg Arg Phe Asp Pro Arg Ser Ala Leu Val 
145                 150                 155                 160 


Leu Tyr Gln Ile Ala Ala Ile Gly Val Arg Ala His Thr Ala Thr Leu 
                165                 170                 175     


Pro Asn Leu Arg Gly Leu Arg Ala Leu Ser Ala Ala Leu Val Glu His 
            180                 185                 190         


Tyr Pro Ala Glu His Gln Ala Ile Val Tyr Thr Ala Ala Glu Tyr Pro 
        195                 200                 205             


Gly Cys Arg Ala Ile Ile Glu Pro Ser Thr Ile Ala Gly Leu Pro Ser 
    210                 215                 220                 


Ala Pro Val Gln Ala Thr Ala Thr Leu Tyr Val Pro Pro Leu 
225                 230                 235             


<210>  196
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  196

Gly Cys Leu Thr Ile Val Gly Thr Gly Ile Gln Phe Val Gly Gln Val 
1               5                   10                  15      


Thr Leu Ala Ala Lys Ala Trp Ile Glu Gln Ala Asp Lys Val Leu Tyr 
            20                  25                  30          


Ala Val Ala Asp Pro Ala Thr Ala Gln Trp Leu Val Ser Val Asn Ser 
        35                  40                  45              


Thr Ala Glu Ala Leu Pro Tyr Asn Arg Asn Asn Arg Gln Arg Lys Glu 
    50                  55                  60                  


Thr Tyr Val Gln Met Val Glu Cys Ile Leu Ala Glu Val His Arg Gly 
65                  70                  75                  80  


Leu Asn Val Cys Val Val Phe Tyr Gly His Pro Gly Val Phe Ala Asp 
                85                  90                  95      


Ser Ala His Gln Ala Leu Arg Arg Ala Arg Gln Glu Gly Phe Arg Ala 
            100                 105                 110         


Gln Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp Leu 
        115                 120                 125             


Ser Leu Asp Pro Gly Lys Arg Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Arg Arg Lys Phe Asp Pro Thr Ser Ala Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Ala Leu Val Gly Asn Arg Gly Phe Tyr Glu Gln Gly Gly 
                165                 170                 175     


His Val Arg Gly Leu His Val Leu Thr Glu Val Leu Gln Asn Tyr Tyr 
            180                 185                 190         


Ala Ser Asp Ser Glu Ala Ile Val Tyr Glu Ala Ala Val Tyr His Pro 
        195                 200                 205             


Val Cys Glu Pro Ser Ile Gln Arg Ile Pro Leu Glu Lys Leu Pro Glu 
    210                 215                 220                 


Ala Lys Val Thr Glu Ser Ser Thr Leu Tyr Met Pro Pro Asn 
225                 230                 235             


<210>  197
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  197

Gly Ser Leu Thr Ile Val Gly Thr Gly Ile Gln Leu Val Ser His Leu 
1               5                   10                  15      


Thr Leu Gly Ala Lys Ala Trp Ile Glu Gln Ala Asp Lys Val Leu Tyr 
            20                  25                  30          


Ala Leu Ala Asp Pro Val Thr Ala Lys Trp Leu Lys Glu Leu Asn Ala 
        35                  40                  45              


Thr Ala Glu Ala Leu Pro Tyr Asn Arg Asn Asn Gln Trp Arg Arg Asp 
    50                  55                  60                  


Thr Tyr Gln Glu Met Thr Glu Arg Ile Leu Thr Asp Val Arg Lys Gly 
65                  70                  75                  80  


Leu Asn Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Asn 
                85                  90                  95      


Pro Ala Gln Ala Ala Ile Lys Gln Ala His Arg Glu Gly Phe Thr Ala 
            100                 105                 110         


Gln Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Gly Arg Asn Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Arg Arg Lys Phe Asp Pro Thr Ser Pro Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Ala Met Val Gly Asn Leu Gly Phe Tyr Lys Pro Glu Glu 
                165                 170                 175     


Gln Phe Arg Pro Leu Thr Ile Leu Thr Glu Val Leu Lys Thr His Tyr 
            180                 185                 190         


Gly Gly Asp His Glu Val Ile Val Tyr Glu Ala Ala Val Tyr Tyr Pro 
        195                 200                 205             


Val Cys Lys Pro Val Ile Gln Arg Ile Pro Leu Ser Lys Leu Pro Gln 
    210                 215                 220                 


Ser Ser Val Thr Glu Val Ser Thr Leu Tyr Ile Pro Pro Gln 
225                 230                 235             


<210>  198
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  198

Gly Ser Leu Thr Val Val Gly Thr Gly Ile Gln Leu Val Gly His Leu 
1               5                   10                  15      


Thr Leu Ala Ala Lys Ala Trp Ile Glu Gln Ala Asp Lys Val Leu Phe 
            20                  25                  30          


Ala Val Ala Asp Pro Val Thr Ala Lys Trp Leu Gln Thr Leu Asn Pro 
        35                  40                  45              


Thr Ala Glu Ala Leu Pro Tyr Asn Thr Asn Asn Gln Arg Arg Arg Glu 
    50                  55                  60                  


Thr Tyr Arg Glu Met Val Asp Arg Ile Leu Ala Glu Val Arg Gln Gly 
65                  70                  75                  80  


Leu Asn Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Tyr 
                85                  90                  95      


Pro Thr His Glu Ala Ile Lys Gln Ala Arg His Glu Gly Phe Arg Ala 
            100                 105                 110         


Gln Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp Leu 
        115                 120                 125             


Gly Ile Asp Pro Gly Arg Asn Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Arg Arg Lys Phe Asp Pro Thr Ser Ala Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Ala Thr Ile Gly Asn Leu Gly Phe Tyr Gln Glu Glu Ile 
                165                 170                 175     


Gln Leu Arg Gly Leu Asn Val Leu Ala Glu Val Leu Glu Thr Tyr Tyr 
            180                 185                 190         


Gly Ser Asp His Glu Val Ile Val Tyr Glu Ala Ala Val Tyr Tyr Pro 
        195                 200                 205             


Val Cys Glu Pro Val Ile Gln His Ile Pro Leu Ser Lys Leu Ala Glu 
    210                 215                 220                 


Ile Arg Val Thr Leu Val Ser Thr Leu Tyr Val Pro Pro Gln 
225                 230                 235             


<210>  199
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  199

Gly Ser Leu Thr Val Val Gly Thr Gly Ile Gln Leu Val Gly His Leu 
1               5                   10                  15      


Thr Leu Ala Ala Arg Ser Trp Ile Glu Gly Ala Asp Lys Val Leu Phe 
            20                  25                  30          


Ala Val Ala Asp Pro Leu Thr Ala Lys Trp Leu Gln Ser Leu Asn Pro 
        35                  40                  45              


Ala Ala Glu Ser Leu Pro Tyr Asp Thr Gly Asn Leu Arg Arg Arg Lys 
    50                  55                  60                  


Thr Tyr Asp Glu Met Val Gly Arg Ile Leu Val Glu Val Arg Ser Gly 
65                  70                  75                  80  


Leu Asn Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Asp 
                85                  90                  95      


Pro Ala His Glu Ala Ile Arg Gln Ala Arg Arg Glu Gly Phe Arg Ala 
            100                 105                 110         


Glu Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Gly Arg Asn Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Arg Arg Lys Phe Asp Pro Thr Ser Val Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Gly Phe Thr Gly Asn Leu Gly Phe Phe Lys Glu Asn Ala 
                165                 170                 175     


His Leu Arg Gly Leu Lys Val Leu Ala Glu Val Leu Gln Thr Asp Tyr 
            180                 185                 190         


Gly Pro Glu His Glu Val Thr Val Tyr Glu Ala Ala Val Tyr Tyr Pro 
        195                 200                 205             


Val Cys Ser Pro Thr Ile Glu Arg Met Arg Leu Cys Glu Leu Pro Asn 
    210                 215                 220                 


Ala Ser Val Thr Pro Val Ser Thr Leu Tyr Val Pro Pro Lys 
225                 230                 235             


<210>  200
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  200

Gly Ser Leu Thr Ile Val Gly Thr Gly Ile Gln Leu Gly Gly His Leu 
1               5                   10                  15      


Thr Leu Ala Ala Gln Ala Trp Ile Lys Gln Ala Asp Lys Leu Leu Phe 
            20                  25                  30          


Ala Val Ala Asp Pro Val Thr Ala Lys Trp Leu Gln Ser Leu Asn Pro 
        35                  40                  45              


Thr Ala Glu Ala Leu Pro Tyr Asn Thr Asp Cys Asp Arg Arg Arg Gln 
    50                  55                  60                  


Thr Tyr Gly Lys Met Val Asp Arg Met Met Glu Ala Val Arg Ala Gly 
65                  70                  75                  80  


Gly Asn Ile Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Asp 
                85                  90                  95      


Pro Ala His Gly Ala Ile Ala Gln Ala Arg Arg Glu Gly Tyr Thr Ala 
            100                 105                 110         


Leu Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp Ile 
        115                 120                 125             


Gly Ile Asp Pro Gly Lys Gly Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Arg Arg Lys Phe Asp Pro Asn Ser His Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Val Ala Leu Ile Gly Asn Leu Gly Phe Tyr Gln Glu Gly Ser 
                165                 170                 175     


Glu Gln Arg Gly Leu Lys Ile Leu Ala Glu Val Leu Gln Glu Asn Tyr 
            180                 185                 190         


Pro Ser Glu His Glu Val Val Ile Tyr Glu Ala Ala Val Tyr Tyr Pro 
        195                 200                 205             


Val Cys Gln Pro Val Ile Asn Pro Ile Pro Leu Asp Ser Leu Pro Leu 
    210                 215                 220                 


Ala Lys Val Thr Thr Val Ser Thr Leu Tyr Val Pro Pro Leu 
225                 230                 235             


<210>  201
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  201

Gly Cys Leu Thr Ile Val Gly Thr Gly Ile Gln Phe Val Gly Gln Val 
1               5                   10                  15      


Thr Leu Ala Ala Lys Ala Trp Ile Glu Gln Ala Asp Lys Val Leu Tyr 
            20                  25                  30          


Ala Val Ala Asp Pro Ala Thr Ala Glu Trp Leu Arg Ser Leu Asn Glu 
        35                  40                  45              


Thr Ala Glu Ser Leu Pro Tyr Asn Thr Asn Asn Gln Trp Arg Lys Gln 
    50                  55                  60                  


Thr Tyr Gly Glu Met Val Glu Val Ile Leu Asn Ala Val Arg Gln Gly 
65                  70                  75                  80  


Leu Asp Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Phe Ala Asn 
                85                  90                  95      


Pro Thr Arg Glu Ala Ile Arg Gln Ala Arg Glu Glu Gly Phe Arg Ala 
            100                 105                 110         


Gln Met Leu Pro Gly Ile Ser Ala Ser Asp Cys Leu Tyr Ala Asp Val 
        115                 120                 125             


Gly Val Asp Pro Gly Gln Tyr Gly Cys Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Leu Arg Asp Arg Arg Phe Asp Pro Arg Ser Ala Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Gly Leu Ile Gly Asn Phe Ser Phe Phe Asp Ala Gln Gly 
                165                 170                 175     


Val Phe Pro Gly Leu Lys Val Leu Thr Glu Val Leu Glu Lys His Tyr 
            180                 185                 190         


Asp Arg Asp His Glu Val Ile Val Tyr Glu Ala Ala Ile Tyr Tyr Pro 
        195                 200                 205             


Val Cys Gln Pro Ile Ile Glu Pro Met Pro Leu Ser Lys Leu Pro Glu 
    210                 215                 220                 


Ala Leu Val Ser Glu Val Ser Thr Leu Tyr Val Pro Pro Gln 
225                 230                 235             


<210>  202
<211>  240
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  202

Gly Ser Leu Val Val Val Gly Ile Gly Ile Gln Trp Ala Gly Gln Thr 
1               5                   10                  15      


Thr Leu Ala Ala Gln Arg Ala Ile Gln Gln Ala Asp Arg Val Leu Phe 
            20                  25                  30          


Ala Val Ala Asp Ala Trp Ala Ala Arg Trp Val Arg Ser Leu Asn Pro 
        35                  40                  45              


Ala Ala Glu Ser Leu Pro Tyr Gly Lys Gly Lys Thr Pro Arg Arg Ser 
    50                  55                  60                  


Ile Tyr Ala Glu Met Val Glu Arg Ile Leu Ala Glu Val Arg Lys Gly 
65                  70                  75                  80  


Leu Lys Val Cys Ala Val Phe Tyr Gly His Pro Gly Val Leu Ala Ser 
                85                  90                  95      


Pro Ala His Ala Ala Val Arg Gln Ala Arg Asp Glu Gly Phe Ser Ala 
            100                 105                 110         


Arg Met Leu Pro Gly Val Ser Ser Ile Asp Cys Leu Phe Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Gly Arg Asp Gly Leu Gln Ile Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Leu Ile Arg Gly Arg Ala Val Asp Ala Arg Thr Pro Leu Val Leu 
145                 150                 155                 160 


Cys Gln Ile Gly Gly Val Gly Cys Ala Gly Val Phe Asp Pro Ser Asp 
                165                 170                 175     


Ala Ala Arg Ile Arg Arg Gly Leu Glu Ala Leu Gly Glu Arg Leu Arg 
            180                 185                 190         


Gln Ser Tyr Pro Ala Ala His Glu Val Val Ile Tyr Glu Ala Ala Ala 
        195                 200                 205             


His Pro Leu Ala Ser Pro Arg Leu Asp Arg Val Ala Leu Ser Ala Leu 
    210                 215                 220                 


Ser Ala Ala Pro Val Asp Asp Val Ser Thr Leu Tyr Val Pro Pro Ala 
225                 230                 235                 240 


<210>  203
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  203

Gly Ser Leu Val Val Ala Gly Ser Gly Ile Lys Gly Ile Ala His Leu 
1               5                   10                  15      


Thr Gln Glu Ala Ala Gly Trp Ile Glu Gln Ala Asp His Val Val Tyr 
            20                  25                  30          


Cys Val Ser Asp Pro Val Thr Asp Val Trp Ile Arg Lys His Ser Lys 
        35                  40                  45              


Ser Ser Asp Asp Leu Tyr Arg Leu Tyr Gly Asn Asp Lys Pro Arg Ile 
    50                  55                  60                  


Arg Thr Tyr Arg Glu Met Thr Asp Ala Met Val Glu Pro Val Arg Arg 
65                  70                  75                  80  


Gly Met Asn Val Cys Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


His Pro Gly His Ala Ala Ile Arg Thr Val Arg Glu Glu Gly Tyr Pro 
            100                 105                 110         


Ala Met Met Leu Pro Gly Val Ser Ala Leu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Ser Arg Pro Gly Cys Gln Glu Leu Glu Ala Thr 
    130                 135                 140                 


Asp Met Leu Leu Arg Asp Arg Pro Leu Leu Ala Glu Ser His Val Val 
145                 150                 155                 160 


Val Trp Gln Ala Gly Cys Val Gly Asp Leu Gly Phe Asn Phe Ala Gly 
                165                 170                 175     


Phe Thr Asn Lys His Leu Gly Val Leu Ala Glu Tyr Leu Asp Arg Phe 
            180                 185                 190         


Tyr Pro Pro Asp His Leu Ile Thr His Tyr Glu Ala Ser Gln Tyr Pro 
        195                 200                 205             


Val Cys Ala Pro His Ile Arg Thr Leu Pro Leu Arg Glu Leu Arg Gln 
    210                 215                 220                 


Glu Pro Leu Thr Gly Ile Ser Thr Leu Tyr Leu Pro Pro Ile 
225                 230                 235             


<210>  204
<211>  220
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  204

Glu Thr Lys Gly Trp Ile Gln Gln Ser Asp Val Val Leu Tyr Cys Val 
1               5                   10                  15      


Ala Asp Pro Thr Thr Glu Val Trp Ile Lys Gln Asn Ser Lys Phe Ser 
            20                  25                  30          


Val Asp Leu Tyr Gln Phe Tyr Gly Asn Asp Arg Arg Arg Leu Asp Thr 
        35                  40                  45              


Tyr Ile Asp Met Ser Asp Glu Met Leu Lys Tyr Val Arg Gln Gly Lys 
    50                  55                  60                  


Ser Val Cys Gly Val Phe Tyr Gly His Pro Gly Val Phe Val Tyr Pro 
65                  70                  75                  80  


Ser His Arg Ala Val Arg Ile Ala Arg Asp Glu Gly His Lys Ala Ala 
                85                  90                  95      


Ile Leu Pro Ala Ile Ser Ala Leu Asp Cys Leu Tyr Ala Asp Cys Asp 
            100                 105                 110         


Val Asp Pro Ser Ser Val Gly Ser Gln Thr Val Glu Ala Thr Asp Leu 
        115                 120                 125             


Leu Leu Arg Ser Arg Gln Leu Leu Thr Asp Glu His Val Val Ile Trp 
    130                 135                 140                 


Gln Ile Gly Cys Val Gly Asp Leu Gly Phe Asn Phe Ser Gly Tyr Asp 
145                 150                 155                 160 


Asn Arg His Leu Asn Ile Leu Val Asp Tyr Leu Glu Lys Phe Tyr Asp 
                165                 170                 175     


Ala Asp His Glu Val Val His Tyr Val Gly Ser Gln Tyr Pro Met Cys 
            180                 185                 190         


Pro Ala Ile Val Gln Arg Met Pro Leu Lys Asp Leu Arg Thr Ala Ser 
        195                 200                 205             


Val Thr Gly Leu Ser Thr Leu Tyr Ile Pro Pro Gln 
    210                 215                 220 


<210>  205
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  205

Ala Glu Leu Ile Val Val Gly Thr Gly Tyr Arg Ala Val Gly Asp Leu 
1               5                   10                  15      


Thr Leu Glu Ala Lys Ala Cys Leu Glu Gln Ala Asp Thr Val Leu Cys 
            20                  25                  30          


Leu Val Gly Asp Pro Met Val Ile Gly Tyr Leu Glu Arg Leu Asn Pro 
        35                  40                  45              


Ser Val Arg Thr Leu Ala Gly Phe Tyr Ala Lys Gly Lys His Arg Ser 
    50                  55                  60                  


Glu Ser Tyr Glu Glu Met Val Gln Glu Ile Leu Ser Glu Val Arg Arg 
65                  70                  75                  80  


Glu Arg Leu Val Cys Cys Ala Phe Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Tyr Pro Gly His Glu Ala Val Arg Arg Ala Arg Leu Glu Gly Ile Pro 
            100                 105                 110         


Ala Arg Met Leu Ala Gly Ser Ser Ala Glu Asp Trp Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Leu Asp Pro Gly Thr Cys Gly Cys Gln Ser Phe Glu Ala Ser 
    130                 135                 140                 


Asp Phe Leu Leu Arg Arg Arg Val Phe Asp Ala Thr Ser Leu Leu Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Val Ile Gly Met Thr Asp Arg Asp Pro Asp Phe 
                165                 170                 175     


Asp Ala Arg Val Gly Ala Ala Leu Leu Ala Glu Arg Leu Ala Gly Ala 
            180                 185                 190         


Tyr Gly Val Asp His Glu Val Val Val Tyr Glu Ala Ser Pro Tyr Pro 
        195                 200                 205             


Val Thr Ser Pro Arg Ile Ser Pro Val Pro Leu Ala Lys Leu Ala Asp 
    210                 215                 220                 


Thr Gln Leu Thr Asn Lys Ser Thr Leu Val Val Pro Pro Leu 
225                 230                 235             


<210>  206
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  206

Ala Gln Leu Val Val Val Gly Thr Gly Tyr Arg Ala Ile Gly Asp Leu 
1               5                   10                  15      


Thr Val Glu Ala Arg Ala Cys Ile Glu Gln Ala Asp Lys Val Leu Cys 
            20                  25                  30          


Leu Ile Gly Asp Pro Leu Val Thr His His Ile Gly Gln Leu Asn Pro 
        35                  40                  45              


Ser Val Glu Thr Leu Asp Gly His Tyr Ala Ala Gly Lys Pro Arg Tyr 
    50                  55                  60                  


Ala Ser Tyr Glu Glu Met Val Glu His Ile Leu Ser Glu Val Arg Arg 
65                  70                  75                  80  


Asp Gln Phe Val Cys Val Ala Leu Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Tyr Ala Gly His Glu Ala Ile Arg Arg Ala Arg Leu Glu Gly Ile Ala 
            100                 105                 110         


Ala Arg Met Val Pro Ala Cys Ser Ala Glu Asp Trp Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Leu Asp Pro Gly Gln Gln Gly Cys Gln Ser Phe Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Thr Arg His Arg Arg Phe Asp Pro Thr Ser Leu Met Ile 
145                 150                 155                 160 


Leu Trp Gln Ile Gly Val Ile Gly Met Pro Asp Ala His Arg Gln Phe 
                165                 170                 175     


Asp Pro Ala Pro Gly Ala Ser Cys Leu Thr Glu Val Leu Val Pro His 
            180                 185                 190         


Tyr Gly Pro Asp His Pro Val Thr Val Tyr Glu Ala Ser Pro Tyr Val 
        195                 200                 205             


Ala Ala Glu Pro Arg Ala Thr Thr Val Pro Leu Ala Lys Leu Pro Asp 
    210                 215                 220                 


Thr Ser Leu Ser Ala Ala Ser Thr Leu Val Val Pro Pro Leu 
225                 230                 235             


<210>  207
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  207

Ala Gln Leu Val Val Val Gly Thr Gly Phe Arg Ala Ile Gly Asp Leu 
1               5                   10                  15      


Thr Val Glu Ala Arg Ala Cys Leu Glu Gln Ala Asp Lys Val Leu Cys 
            20                  25                  30          


Leu Ile Gly Asp Pro Leu Val Thr Arg His Ile Glu Lys Leu Asn Ala 
        35                  40                  45              


Ser Val Glu Thr Leu Asp Val His Tyr Ala Val Gly Lys Pro Arg Ser 
    50                  55                  60                  


Ala Ser Tyr Glu Asp Met Val Glu His Ile Met Ser Glu Leu His Arg 
65                  70                  75                  80  


Asp Gln Phe Val Cys Val Ala Leu Tyr Gly His Pro Gly Val Phe Ala 
                85                  90                  95      


Tyr Thr Gly His Glu Ala Ile Arg Arg Ala Arg Glu Glu Gly Ile Ala 
            100                 105                 110         


Ala Arg Met Leu Pro Ala Cys Ser Ala Glu Asp Trp Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Leu Asp Pro Gly Glu Arg Gly Cys Gln Ser Phe Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Ile Arg His Arg Val Phe Asp Pro Thr Gly Leu Leu Ile 
145                 150                 155                 160 


Leu Trp Gln Val Gly Val Ile Gly Met Ile Asp Arg Asp Pro Gly Tyr 
                165                 170                 175     


Asp Ala Arg Pro Gly Val Thr Thr Leu Thr Asp Ala Leu Val Ala Ser 
            180                 185                 190         


Tyr Gly Ser Gly His Pro Val Thr Val Tyr Glu Ala Ser Pro Tyr Val 
        195                 200                 205             


Thr Ala Glu Pro Arg Thr Thr Thr Val Pro Leu Ala Glu Leu Pro Asp 
    210                 215                 220                 


Thr Pro Leu Ser Ala Ala Ser Thr Leu Val Val Pro Pro Leu 
225                 230                 235             


<210>  208
<211>  242
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  208

Gly Ser Leu Ile Val Val Gly Thr Gly Ile Arg Ala Gly His Leu Ser 
1               5                   10                  15      


Gln Glu Ala Ile Ser Ala Val Arg Thr Ala Asp Ala Val Ala Tyr Cys 
            20                  25                  30          


Ile Ala Glu Pro Leu Thr Arg Leu Leu Val Asp Glu Leu Arg Lys Glu 
        35                  40                  45              


Ala Ala Lys Pro Val Ala Glu Asp Leu His Arg Phe Tyr Ala Asp Gly 
    50                  55                  60                  


Lys Pro Arg Thr Gln Thr Tyr His Gln Met Val Ala Arg Ile Leu Glu 
65                  70                  75                  80  


Leu Val Arg Leu Asp Leu Gln Val Ala Ala Val Phe Tyr Gly His Pro 
                85                  90                  95      


Gly Val Phe Ala Tyr Pro Ser His Glu Ser Ile Arg Gln Ala Arg Ala 
            100                 105                 110         


Glu Gly Tyr Pro Ala Glu Met Leu Pro Gly Ile Ser Ala Val Asp Cys 
        115                 120                 125             


Leu Phe Ala Asp Leu Gly Val Asp Pro Ala Thr Ala Gly Cys Gln Met 
    130                 135                 140                 


Leu Glu Ala Thr Asp Phe Leu Leu Arg Arg Arg His Leu Asp Thr Ala 
145                 150                 155                 160 


Cys Gly Val Val Leu Trp Gln Ile Gly Cys Val Gly His Gly Asp Tyr 
                165                 170                 175     


Gln Gly Ser Gly Tyr Asp Leu Arg Tyr Ile Pro Met Leu Val Glu Ala 
            180                 185                 190         


Leu Leu Ala Phe Tyr Pro Pro Glu His Glu Val Val Val Tyr Gln Ala 
        195                 200                 205             


Ala His Phe Ala Met Cys Asp Pro Ile Val Glu Cys Val Ala Ile Ala 
    210                 215                 220                 


Glu Met Leu Lys Ala Ser Ile Thr Ala Val Ser Thr Leu Tyr Ile Pro 
225                 230                 235                 240 


Pro Leu 
        


<210>  209
<211>  238
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  209

Gly Ser Leu Val Val Val Gly Thr Gly Leu His Val Gly Gln Leu Thr 
1               5                   10                  15      


Leu Glu Ser Arg Ala Asn Ile Glu Val Ala Asp His Val Val Tyr Leu 
            20                  25                  30          


Val Thr Asp Ser Val Thr Glu Glu Phe Ile Leu Ser Leu Asn Ser Asn 
        35                  40                  45              


Ala Glu Ser Leu Arg Gln Tyr Tyr Ala Asp Asp Lys Asn Arg Leu Ile 
    50                  55                  60                  


Ser Tyr Glu Glu Met Ile Ala His Ile Thr Asn Leu Val His Asn Asn 
65                  70                  75                  80  


Leu Glu Val Cys Ala Val Phe Tyr Gly His Pro Gly Ile Phe Val Tyr 
                85                  90                  95      


Pro Ser His Glu Ser Ile Gln Arg Leu Arg Gln Glu Gly Tyr Lys Ala 
            100                 105                 110         


Arg Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Tyr Ala Asp Leu 
        115                 120                 125             


Gly Ile Asp Pro Gly Arg Gln Gly Ser Gln Ser Phe Glu Ala Thr Asp 
    130                 135                 140                 


Phe Ile Leu Arg Asp Arg Ile Phe Asp Pro His Ser Tyr Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Ile Gly Ser Leu Gly Ser Tyr Thr Phe Ser Ser Thr Gly Ile 
                165                 170                 175     


Tyr Asp Arg Arg Gly Val Asp Ile Leu Leu Asn Lys Leu Leu Ser Asn 
            180                 185                 190         


Tyr Pro Ser Asn His Glu Val Ile Leu Tyr Lys Ala Ser Val Ile Pro 
        195                 200                 205             


Leu Cys Ser His Glu Val Gln Arg Phe Ala Leu Cys Asp Leu Val Thr 
    210                 215                 220                 


Ala Lys Thr Asn Gly Ser Met Thr Leu Ile Ile Pro Pro Cys 
225                 230                 235             


<210>  210
<211>  242
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  210

Gly Thr Leu Val Leu Met Gly Ser Gly Ile Arg Ala Ile Gly Gln Phe 
1               5                   10                  15      


Thr Leu Glu Ser Gln Glu Tyr Leu Arg Trp Ala Asp Arg Val Phe Tyr 
            20                  25                  30          


Cys Val Ser Asp Pro Thr Thr Glu Arg Trp Ile Leu Asp Gln Gln Pro 
        35                  40                  45              


Asp Ala Val Asp Leu Tyr Thr Leu Tyr Asp Asn Asp Lys Pro Arg Arg 
    50                  55                  60                  


Ile Thr Tyr Val Gln Met Ala Glu Ser Met Leu Arg Pro Leu Arg Glu 
65                  70                  75                  80  


Gly Leu Asn Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ser His Arg Ala Ile Ala Ile Ala Arg Gln Glu Gly His Ala 
            100                 105                 110         


Ala Phe Met Leu Pro Ala Val Ser Ala Leu Asp Cys Leu Phe Ser Asp 
        115                 120                 125             


Leu Gly Ile Asp Pro Ser Arg Pro Gly Cys Gln Ile Ile Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Lys Arg Gln Leu Leu Thr Asp Ser His Val Val 
145                 150                 155                 160 


Leu Leu Gln Val Gly Ser Val Gly Asp Thr Gly Phe Arg Phe Ala Gly 
                165                 170                 175     


Phe Pro Asn Thr His Leu Gly Ala Leu Val Asn Tyr Leu Gln Glu Ala 
            180                 185                 190         


Tyr Gly Pro Asp His Glu Ile Val Asn Tyr Ile Ala Ala Gln Tyr Ala 
        195                 200                 205             


Ile Ala Asp Pro Val Val Gln Arg Val Lys Leu Ser Glu Leu Leu Glu 
    210                 215                 220                 


Pro Glu Asn Ser Arg Arg Val Thr Gly Ile Ser Thr Phe Tyr Val Pro 
225                 230                 235                 240 


Pro Val 
        


<210>  211
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  211

Gly Arg Leu Val Val Ile Gly Ser Gly Ile Lys Ala Val Ser His Phe 
1               5                   10                  15      


Thr Leu Glu Ala Gln Gln His Ile Arg Asn Ala Asp Ile Val Leu Tyr 
            20                  25                  30          


Ala Ala Ala Asp Pro Val Thr Asp Ile Trp Ile Gln Lys Gln Asn Lys 
        35                  40                  45              


Asn Ser Phe Asp Leu Tyr Gln Tyr Tyr Ala Asp Asp Lys Ser Arg Ile 
    50                  55                  60                  


Ile Thr Tyr Ser Gln Met Ile Glu Arg Thr Met Gln Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Tyr Val Cys Ala Leu Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Asn Ala Ile Ala Ile Ala Arg Ser Glu Gly Tyr His 
            100                 105                 110         


Ala Val Met Leu Pro Ala Ile Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Ser Val Pro Gly Leu Gln Ile Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Leu Arg Arg Arg His Ile Asp Thr Ser Ala Asn Phe Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Cys Ile Gly Asp Leu Gly Phe Lys Phe Gly Gly 
                165                 170                 175     


Tyr Gln Asn Asp Lys Leu Asp Val Leu Leu Asp Tyr Leu Glu Glu Ile 
            180                 185                 190         


Tyr Gly Pro Asp His Ile Ala Ile Asn Tyr Val Ala Asn Met Phe Ser 
        195                 200                 205             


Gly Glu Pro Thr Ile Asp Arg His Arg Ile Ala Asp Tyr Arg Asp Pro 
    210                 215                 220                 


Glu Val Lys Arg Thr Val Ser Gly Ile Ser Thr Phe Phe Leu Pro Ala 
225                 230                 235                 240 


Lys 
    


<210>  212
<211>  242
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  212

Gly Lys Leu Ile Val Ile Gly Ser Gly Ile Lys Ser Ile Ala His Phe 
1               5                   10                  15      


Thr Leu Glu Ser Gln Ala His Leu Gln Gln Ala Asp Ile Val Leu Tyr 
            20                  25                  30          


Ala Ala Ser Asp Pro Val Thr Asp Met Trp Ile Gln Lys Gln Asn Pro 
        35                  40                  45              


Asn Ser Phe Asp Leu Tyr Gln Tyr Tyr Gly Asn Thr Lys Asn Arg Ile 
    50                  55                  60                  


Ile Thr Tyr Thr Gln Met Ile Glu Arg Val Met Met Glu Leu Arg Ser 
65                  70                  75                  80  


Gly Lys Tyr Val Cys Ala Leu Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Asn Ala Ile Glu Leu Ala Arg Arg Glu Gly Tyr Glu 
            100                 105                 110         


Ala Glu Met Leu Pro Gly Ile Ser Ala Glu Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Ser Ile Pro Gly Leu Gln Thr Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Gln Arg Ser Ile Asn Thr Glu Ile Asn Ala Val 
145                 150                 155                 160 


Ile Trp Gln Val Gly Cys Val Gly Asp Val Gly Phe Lys Phe His Gly 
                165                 170                 175     


Tyr Asp Asn Glu Lys Leu Asn Ile Leu Leu Asp Tyr Leu Asp Lys Phe 
            180                 185                 190         


Tyr Pro Pro Asp Gln Ile Val Tyr Asn Tyr Val Ala Ser Met Phe Ser 
        195                 200                 205             


Met Ala Lys Pro Lys Lys Asp Lys Phe Lys Leu Ser Asp Phe Arg Asp 
    210                 215                 220                 


Pro Ser Ile Ala Lys Glu Val Thr Gly Ile Ser Thr Phe Phe Ile Pro 
225                 230                 235                 240 


Ala Val 
        


<210>  213
<211>  242
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  213

Gly His Leu Val Ile Val Gly Ser Gly Ile Lys Ser Leu Ala Gln Leu 
1               5                   10                  15      


Thr Met Glu Ala Val Gly His Ile Lys Ala Ala Asp Glu Val Phe Tyr 
            20                  25                  30          


Ala Val Ala Asp Pro Leu Thr Glu Ala Phe Ile Glu Lys Asn Ala Lys 
        35                  40                  45              


Lys Ala Tyr Asp Met Tyr Ile Leu Tyr Asp Asp Gly Lys Pro Arg Leu 
    50                  55                  60                  


Gln Thr Tyr Val Gln Met Ala Glu Val Met Leu Arg Ala Leu Arg Gln 
65                  70                  75                  80  


Gly Lys Tyr Val Val Gly Val Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Asn Pro Ser His Arg Ala Ile Ala Ile Ala Lys Glu Glu Gly Phe Arg 
            100                 105                 110         


Ala Glu Met Leu Ala Gly Ile Ser Ala Glu Asp Asn Leu Phe Ala Asp 
        115                 120                 125             


Ile Gly Ile Asp Pro Ser Arg His Gly Cys Gln Thr Leu Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Lys Arg Ile Leu Leu Thr Asp Ser His Val Val 
145                 150                 155                 160 


Ile Leu Gln Val Gly Ala Val Gly Asp Leu Gly Phe Asn Phe Ser Gly 
                165                 170                 175     


Phe Lys Asn Gln His Phe Gln Val Leu Ile Asp Arg Leu Ile Lys Glu 
            180                 185                 190         


Tyr Gly Pro Gln His Asp Val Tyr Leu Tyr Ala Ala Pro Ser Ile Ala 
        195                 200                 205             


Ile Ala Asn Pro Leu Val Glu Lys Tyr Lys Ile Ala Asp Phe Arg Lys 
    210                 215                 220                 


Pro Glu Val Val Lys Arg Val Thr Gly Ile Ser Thr Phe Tyr Leu Pro 
225                 230                 235                 240 


Pro Lys 
        


<210>  214
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  214

Gly Glu Leu Thr Ile Ile Gly Ser Gly Ile Glu Thr Met Gly Phe Thr 
1               5                   10                  15      


Ile Gly Asp Glu Glu Leu Ile Arg Gly Ala Asp Ala Val Phe Phe Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Val Val Trp Leu Lys Ser Ile Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Tyr Val Leu Tyr Asp Asp Thr Lys Val Arg Tyr Thr 
    50                  55                  60                  


Thr Tyr Met Gln Met Ser Glu Ala Met Leu His His Val Arg Gln Gly 
65                  70                  75                  80  


Lys Lys Val Val Ala Val Tyr Tyr Gly His Pro Gly Ile Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Cys Ile Met Ile Ala Arg Arg Glu Gly His Lys Ala 
            100                 105                 110         


Val Met Arg Pro Gly Val Cys Ala Leu Asp Cys Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Cys His Pro Gly Met Gln Thr His Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Ile Arg Gly Arg Ile Pro Asp Thr Ser Leu His Val Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Met Gly Phe Arg Arg Arg Gly Tyr 
                165                 170                 175     


Ile Asn Asn Asn Phe Ser Val Phe Val Glu Tyr Leu Gln Lys Tyr Tyr 
            180                 185                 190         


Gly Asp Asp Tyr Pro Val Thr His Tyr Ile Ala Ser Arg Tyr Pro Thr 
        195                 200                 205             


Ile Pro Pro Thr Ile Glu Val Tyr Pro Leu Ser Ala Leu His Asp Pro 
    210                 215                 220                 


Gln Ile Gln Thr Arg Val Thr Gly Val Ser Thr Phe Tyr Val Pro Pro 
225                 230                 235                 240 


Lys 
    


<210>  215
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  215

Gly Glu Leu Thr Ile Ile Gly Ser Gly Ile Glu Thr Val Gly Phe Ser 
1               5                   10                  15      


Leu Gly Asp Gln Glu Leu Ile Arg Ser Ala Asp His Val Phe Tyr Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Val Val Trp Ile Arg Asp Leu Arg Pro Asp 
        35                  40                  45              


Ala His Asp Leu Tyr Val Leu Tyr Asp Asp Asn Lys Val Arg Tyr Val 
    50                  55                  60                  


Thr Tyr Met Gln Met Ala Glu Ala Met Leu His His Val Arg Gln Ala 
65                  70                  75                  80  


Lys Lys Val Val Ala Ile Tyr Tyr Gly His Pro Gly Val Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Ala Ile Leu Ile Ala Arg Arg Glu Gly His Arg Ala 
            100                 105                 110         


Thr Met Arg Ala Gly Val Ser Ala Leu Asp Cys Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser His Pro Gly Leu Gln Thr His Glu Ala Ser Asp 
    130                 135                 140                 


Met Leu Ile Arg Leu Arg Lys Pro Asp Thr Ser Leu His Val Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Met Gly Phe Arg Arg Lys Gly Tyr 
                165                 170                 175     


Val Asn Ser Asn Phe Ser Ile Leu Ile Asp Tyr Leu Gln Gly Val Tyr 
            180                 185                 190         


Gly Lys Asp Tyr Pro Val Thr His Tyr Val Ala Ser Arg Tyr Pro Thr 
        195                 200                 205             


Ile Pro Pro Leu Ile Glu Thr Tyr Pro Leu Ser Arg Leu His Glu Pro 
    210                 215                 220                 


Asp Ile Gln Leu Arg Val Thr Gly Ile Ser Thr Phe Tyr Leu Ala Pro 
225                 230                 235                 240 


Arg 
    


<210>  216
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  216

Gly Glu Leu Ile Ile Ile Gly Ser Gly Ile Glu Thr Ile Gly Ile Ser 
1               5                   10                  15      


Leu Gly Asp Gln Lys Leu Ile Glu Ala Ala Asp Lys Val Leu Phe Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Ile Val Trp Leu Lys Arg Leu Arg Pro Asp 
        35                  40                  45              


Ala Leu Asp Leu Tyr Val Leu Tyr Gly Glu Asn Lys Val Arg Tyr Thr 
    50                  55                  60                  


Thr Tyr Met Gln Met Thr Glu Ala Gln Leu Tyr Trp Val Arg Gln Gly 
65                  70                  75                  80  


Leu Lys Val Val Val Val Phe Tyr Gly His Pro Gly Ile Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Ala Ile Lys Ile Ala Arg Arg Glu Gly Tyr Lys Ala 
            100                 105                 110         


Val Met Lys Ala Gly Val Cys Ala Leu Asp Thr Leu Cys Ala Asp Ile 
        115                 120                 125             


Gly Ile Asp Pro Cys His Pro Gly Leu Gln Thr His Glu Ala Thr Asp 
    130                 135                 140                 


Ala Leu Val Arg Gln Arg Asn Leu Asp Thr Ser Leu His Val Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Leu Gly Phe Arg Arg Gln Gly Tyr 
                165                 170                 175     


Leu Asn Asn Asp Phe Ser Tyr Phe Ile Ser Trp Leu Gln Asn Ile Tyr 
            180                 185                 190         


Gly Glu Glu Tyr Lys Val Thr His Tyr Ile Gly Ser Arg Tyr Pro Thr 
        195                 200                 205             


Ile Pro Pro Leu Ile Glu Ile Tyr His Leu Asn Glu Met His Asp Pro 
    210                 215                 220                 


Glu Thr Gln Leu Lys Ile Thr Gly Leu Ser Thr Phe Tyr Ile Pro Pro 
225                 230                 235                 240 


Arg 
    


<210>  217
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  217

Gly Ser Leu Glu Ile Leu Gly Ser Gly Ile Glu Ala Ser Gly Phe Thr 
1               5                   10                  15      


Arg Ala Asp Glu Ala Arg Ile Arg Ala Ala Asp His Val Phe Phe Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Lys Val Trp Leu Leu Arg Glu Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Tyr Thr Leu Tyr Asp Asp Ser Lys Arg Arg Tyr Val 
    50                  55                  60                  


Thr Tyr Met Gln Met Ala Glu Ala Ile Leu His Pro Val Arg Gln Gly 
65                  70                  75                  80  


Gln Arg Val Val Ala Ile Phe Tyr Gly His Pro Gly Val Phe Val Leu 
                85                  90                  95      


Ala Thr His Arg Ala Val Arg Ile Ala Arg Arg Glu Gly His Arg Ala 
            100                 105                 110         


Glu Met Arg Ala Ala Val Ser Ala Leu Asp Thr Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser Gln Pro Gly Met Gln Met Tyr Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Ile Arg Ser Arg Arg Pro Asp Thr Gly Leu His Leu Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Leu Gly Tyr Arg Arg Gln Gly Tyr 
                165                 170                 175     


Leu Asn Ser Asn Phe Ser Val Leu Leu Asp Tyr Leu Glu Ala Leu Tyr 
            180                 185                 190         


Gly Ala Asp Gln Pro Val Val Asn Tyr Val Gly Ser Arg Tyr Pro Gly 
        195                 200                 205             


Val Asp Pro Leu Ile Asp Arg Gln Thr Ile Ala Ser Leu Arg Asp Pro 
    210                 215                 220                 


Ser Val Gln Asn Trp Val Thr Gly Ile Ser Thr Phe Tyr Leu Pro Pro 
225                 230                 235                 240 


Lys 
    


<210>  218
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  218

Gly Thr Leu Glu Ile Leu Gly Ser Gly Ile Glu Ala Ser Asp Phe Ser 
1               5                   10                  15      


Arg Ser Asp Glu Ala Arg Ile Leu Val Ala Asp His Val Phe Tyr Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Lys Ile Trp Ile Leu Ser Gln Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Tyr Val Leu Tyr Asp Asp Ser Lys Pro Arg Tyr Leu 
    50                  55                  60                  


Thr Tyr Met Gln Met Thr Glu Ala Met Leu His His Val Arg Asn Gly 
65                  70                  75                  80  


Glu His Val Val Ala Ile Phe Tyr Gly His Pro Gly Val Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Ala Val Thr Ile Ala Arg Arg Glu Gly His His Ala 
            100                 105                 110         


Ser Met Arg Ala Ala Val Ser Ala Leu Asp Thr Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser Gln Pro Gly Met Gln Met Tyr Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Ile Arg Arg Arg Gln Pro Asp Pro Gly Leu His Leu Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Leu Gly Tyr Arg Arg Gln Gly Tyr 
                165                 170                 175     


Leu Asn Ser Asn Phe Ala Val Leu Leu Asp Tyr Leu Glu Asp Leu Tyr 
            180                 185                 190         


Gly Pro Glu His Pro Val Ile Asn Tyr Val Gly Ser Arg Tyr Pro Gly 
        195                 200                 205             


Ile Asp Pro Leu Ile Asp Arg Gln Thr Leu Ala Ser Leu Arg Asp Pro 
    210                 215                 220                 


Leu Ala Gln Ser Trp Val Thr Gly Ile Ser Thr Phe Tyr Leu Pro Pro 
225                 230                 235                 240 


Arg 
    


<210>  219
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  219

Gly Glu Leu Thr Ile Leu Gly Ser Gly Ile Glu Thr Val Gly Phe Thr 
1               5                   10                  15      


Ser Ala Asp Glu Ile Arg Ile Arg Glu Ala Asp Lys Val Phe Tyr Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Val Val Trp Leu Lys Arg Leu Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Tyr Val Leu Tyr Asp Asp Thr Lys Ile Arg Tyr Thr 
    50                  55                  60                  


Thr Tyr Met Gln Met Thr Glu Ala Met Leu His Phe Val Arg Glu Gly 
65                  70                  75                  80  


Gln Asn Val Val Ala Ile Phe Tyr Gly His Pro Gly Val Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Ala Val Gln Ile Gly Gln Arg Glu Gly His Lys Val 
            100                 105                 110         


Thr Met Arg Ala Gly Ile Ser Ala Leu Asp Thr Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Ile Asp Pro Ser Gln Pro Gly Met Gln Thr Phe Glu Ala Thr Asp 
    130                 135                 140                 


Thr Leu Ile Arg Lys Arg His Leu Asp Pro Glu Leu His Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Val Gly Asp Leu Gly Tyr Arg Arg Glu Gly Ser 
                165                 170                 175     


Leu Asn Ser Gly Phe Ser Val Leu Leu Asp Tyr Leu Glu Glu Thr Tyr 
            180                 185                 190         


Gly Pro Asp His Glu Val Val Asn Tyr Ile Gly Ser Arg Tyr Pro Gly 
        195                 200                 205             


Ala Asp Pro Val Arg Asp Arg His Thr Ile Ser Ser Leu Arg Asn Pro 
    210                 215                 220                 


Ala Val Gln Ser Thr Ile Thr Gly Ile Ser Thr Phe Tyr Ile Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  220
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  220

Gly Asp Leu Thr Ile Ile Gly Ser Gly Ile Glu Ala Val Gly Phe Thr 
1               5                   10                  15      


Ser Val Asp Glu Ser Leu Ile Lys Arg Ala Asp Tyr Val Phe Phe Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Ser Val Trp Ile Lys Ser Ile Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Tyr Val Leu Tyr Asp Asp Ser Lys Leu Arg Tyr Leu 
    50                  55                  60                  


Thr Tyr Ile Gln Met Ser Glu Ala Ile Leu His Tyr Val Arg Arg Gly 
65                  70                  75                  80  


Ala Lys Val Val Ala Ile Tyr Tyr Gly His Pro Gly Val Phe Val Phe 
                85                  90                  95      


Ser Thr His Arg Ala Val Gln Ile Ala Arg Arg Glu Gly His Lys Ala 
            100                 105                 110         


Val Met Arg Ala Asn Val Ser Ala Leu Asp Thr Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser Gln Pro Gly Met Gln Thr Phe Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Ile Arg Gln Arg Gln Ile Asp Thr Gly Leu His Leu Ile Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Glu Leu Gly Tyr Arg Arg Gln Gly Tyr 
                165                 170                 175     


Leu Asn Asn Ser Phe Ser Val Leu Leu Asp Tyr Ile Glu Glu Ala Tyr 
            180                 185                 190         


Gly Ser Asp Tyr Pro Ile Val Asn Tyr Ile Gly Ser Arg Tyr Pro Gly 
        195                 200                 205             


Ile Asp Pro Thr Lys Asp Gln His Thr Val Ser Ser Leu Arg Val Pro 
    210                 215                 220                 


Glu Ala Gln Ser Thr Val Thr Gly Ile Ser Thr Phe Tyr Ile Pro Pro 
225                 230                 235                 240 


Lys 
    


<210>  221
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  221

Gly Glu Leu Thr Val Leu Gly Ser Gly Ile Glu Ala Ala Gly Phe Thr 
1               5                   10                  15      


Arg Ala Asp Glu Arg Leu Leu Arg Glu Ala Asp His Val Phe His Cys 
            20                  25                  30          


Val Ala Asp Pro Val Thr Val Val Arg Ile Lys Ala Trp Arg Pro Asp 
        35                  40                  45              


Ser Tyr Asp Leu Gly Val Leu Tyr Asp Asp Ala Lys Asp Arg Tyr Leu 
    50                  55                  60                  


Thr Tyr Val Gln Met Ser Glu Ala Ile Leu His Phe Val Arg Ala Gly 
65                  70                  75                  80  


Arg Arg Val Ala Ala Val Phe Tyr Gly His Pro Gly Val Phe Val Leu 
                85                  90                  95      


Ser Ser His Arg Ala Val Arg Ile Ala Arg Arg Glu Gly His Ala Ala 
            100                 105                 110         


Val Met Arg Pro Gly Ile Ser Ala Leu Asp Val Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser Ser Pro Gly Met Gln Thr Phe Glu Ala Ser Asp 
    130                 135                 140                 


Leu Leu Ile Arg Gly Arg Arg Ile Asp Pro Gly Leu His Leu Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Val Gly Glu Leu Gly Tyr Gln Arg Thr Gly Phe 
                165                 170                 175     


Phe Asn His Arg Leu Pro Val Leu Val Asp Arg Leu Glu Glu Val Tyr 
            180                 185                 190         


Gly Pro Asp His Pro Val Val Asn Tyr Ile Gly Ala Arg Tyr Arg Gly 
        195                 200                 205             


Thr Ala Pro Val Thr Asp Arg His Thr Val Ala Gly Leu Arg Asp Arg 
    210                 215                 220                 


Ala Val Gln Arg Thr Val Thr Ser Ala Ser Thr Trp Tyr Leu Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  222
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  222

Gly Glu Leu Thr Ile Ile Gly Ser Gly Ile Gly Val Met Gly Phe Thr 
1               5                   10                  15      


Arg Asp Ala Glu Gln Tyr Ile Asp Asp Ala Asp His Val Val Phe Cys 
            20                  25                  30          


Val Ala Asp Pro Ala Thr Gln Val Trp Leu Arg Gly Arg Arg Pro Asp 
        35                  40                  45              


Ala Ile Asp Leu Phe Ala Leu Tyr Asp Asp Arg Lys Pro Arg Tyr His 
    50                  55                  60                  


Thr Tyr Met Gln Met Thr Glu Ala Met Leu Tyr His Val Arg Arg Gly 
65                  70                  75                  80  


Lys Arg Val Ala Ala Val Phe Tyr Gly His Pro Gly Ile Phe Val Leu 
                85                  90                  95      


Ser Thr His Arg Ala Val Ala Ile Ala Arg Arg Glu Gly His Arg Ala 
            100                 105                 110         


Gln Leu Arg Pro Gly Val Ser Ala Leu Asp Trp Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Ile Asp Pro Ala Tyr Pro Gly Met Gln Thr Phe Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Leu Arg Arg Arg Ala Ile Asp Pro Gly Ser His Val Val Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Ala Glu Met Gly Phe Arg Arg Arg Gly Phe 
                165                 170                 175     


His Asn Arg Arg Phe Asp Tyr Leu Val Glu Tyr Leu Arg Gly Tyr Tyr 
            180                 185                 190         


Lys Pro Asp His Lys Ile Val His Tyr Ile Ala Ser Arg Tyr Pro Thr 
        195                 200                 205             


Leu Pro Pro Val Ile Glu Arg Tyr Thr Leu Asp Glu Leu Gln Asn Pro 
    210                 215                 220                 


Glu Val His Ala Leu Ile Thr Gly Ile Ser Thr Phe Tyr Val Pro Pro 
225                 230                 235                 240 


Ala 
    


<210>  223
<211>  243
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  223

Gly Ser Leu Thr Val Val Gly Thr Gly Leu Arg Ala Leu Ser His Met 
1               5                   10                  15      


Thr Leu Glu Ala Ile Ser His Ile Arg Asp Ala Asp Arg Val Phe Phe 
            20                  25                  30          


Ser Val Pro Asp Gly Val Thr Ala Arg Gln Ile Arg Asp Ile Asn Pro 
        35                  40                  45              


Glu Ala Val Asp Leu Thr Gln Tyr Tyr Gly Glu Asp Lys Arg Arg Lys 
    50                  55                  60                  


Gln Thr Tyr Val Gln Met Ser Glu Val Ile Leu Arg Glu Val Arg Ala 
65                  70                  75                  80  


Gly Ser Ala Val Thr Ala Val Phe Tyr Gly His Pro Gly Phe Phe Val 
                85                  90                  95      


Phe Pro Ala Arg Arg Ile Leu Ser Ile Ala Arg Lys Glu Gly Tyr Arg 
            100                 105                 110         


Ala Val Met Leu Pro Gly Ile Ser Ser Leu Asp Cys Leu Met Ala Asp 
        115                 120                 125             


Leu Arg Val Asp Pro Ser Val Asn Gly Cys Gln Ile Leu Glu Ala Thr 
    130                 135                 140                 


Asp Leu Leu Leu Arg Asn Arg Pro Ile Ile Thr Ser Gly His Val Ile 
145                 150                 155                 160 


Ile Leu Gln Val Gly Ser Val Gly Asp Ser Ala Phe Ser Phe Thr Ala 
                165                 170                 175     


Gly Phe Arg His Ala Lys Arg Ala Val Leu Phe Glu Arg Leu Ile Glu 
            180                 185                 190         


Ala Tyr Gly Glu Glu His Arg Ser Val Leu Tyr Leu Ala Ala Thr Tyr 
        195                 200                 205             


Pro Gly Leu Asp Gly Gln Ala Val Val Arg Pro Leu Gly Ala Tyr Arg 
    210                 215                 220                 


Asp Pro Lys Val Leu Ala Ser Val Pro Pro Ala Gly Thr Leu Tyr Ile 
225                 230                 235                 240 


Pro Ala Lys 
            


<210>  224
<211>  242
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  224

Gly Ser Leu Thr Val Val Gly Thr Gly Ile Arg Ala Val Ser His Leu 
1               5                   10                  15      


Thr Gln Glu Ala Ile Gly His Ile Arg Asp Ala Asp Ala Val Phe Tyr 
            20                  25                  30          


Ser Val Pro Asp Gly Ile Thr Ala Ala Tyr Ile Arg Asp Leu Asn Pro 
        35                  40                  45              


Asn Ala Thr Asn Leu Ser Val Leu Tyr Gly Glu Asp Lys Arg Arg Ser 
    50                  55                  60                  


Val Thr Tyr Val Gln Met Ala Glu Val Ile Leu Arg Ala Val Arg Gln 
65                  70                  75                  80  


Gly Lys Thr Val Val Ala Val Phe Tyr Gly His Pro Gly Tyr Phe Val 
                85                  90                  95      


Asn Pro Ala Arg Arg Ala Leu Thr Ile Ala Arg Lys Glu Gly His Ala 
            100                 105                 110         


Thr Ala Met Leu Pro Gly Ile Ser Ser Thr Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Arg Ile Asp Pro Ser Phe Gln Gly Cys Gln Ile Leu Glu Ala Thr 
    130                 135                 140                 


Asp Tyr Leu Leu Arg Asp Arg Pro Leu Val Thr Ser Gly His Val Val 
145                 150                 155                 160 


Leu Leu Gln Val Gly Ser Val Gly Asp Ala Tyr Phe Ser Tyr Gly Gly 
                165                 170                 175     


Phe Lys Asn Ser Lys Arg Ala Val Leu Phe Glu Arg Leu Ile Glu Thr 
            180                 185                 190         


Tyr Gly Pro Asp His Pro Cys Val His Tyr Val Gly Ala Thr Phe Pro 
        195                 200                 205             


Gly Thr Asp Pro Gln Val Thr Arg Arg Pro Leu Gly Ala Tyr Arg Asp 
    210                 215                 220                 


Pro Lys Val Leu Ala Gly Ile His Tyr Ala Cys Ser Leu Tyr Ile Pro 
225                 230                 235                 240 


Pro Lys 
        


<210>  225
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  225

Gly Asp Leu Ile Ile Leu Gly Ala Gly Ile Ala Ser Val Gly Phe Thr 
1               5                   10                  15      


Met Asp Ala Glu Met Tyr Ile Arg Arg Ala Asp Ser Val Phe Tyr Val 
            20                  25                  30          


Val Thr Asp Pro Val Thr Glu Val Trp Ile Asn Lys Leu Arg Pro Asp 
        35                  40                  45              


Ala Tyr Asp Leu Ser Thr Leu Tyr Asn Asp Asn Lys Pro Arg Tyr Asn 
    50                  55                  60                  


Thr Tyr Met Gln Met Thr Glu Ala Met Leu Tyr Asp Val Arg Gln Gly 
65                  70                  75                  80  


Arg Thr Val Val Gly Ile Phe Tyr Gly His Pro Gly Ile Phe Ala Leu 
                85                  90                  95      


Ser Thr His Arg Ala Ile Met Ile Ala Arg Arg Glu Gly His Arg Ala 
            100                 105                 110         


Val Met Lys Pro Gly Ile Ser Ala Leu Asp Cys Leu Cys Ala Asp Leu 
        115                 120                 125             


Gly Val Asp Pro Ser Tyr Pro Gly Met Gln Thr Met Glu Ala Thr Asp 
    130                 135                 140                 


Met Leu Leu Arg Gly Lys Lys Pro Asp Thr Thr Gln His Val Ile Leu 
145                 150                 155                 160 


Trp Gln Val Gly Leu Ile Gly Ile Tyr Asp Phe Arg Arg Arg Gly Phe 
                165                 170                 175     


Ile Asn Lys Asn Phe Asn Ile Phe Ile Arg Phe Leu Gln Asn Val Tyr 
            180                 185                 190         


Gly Glu Asp Tyr Ser Ile Thr His Tyr Val Ala Ala Ser Phe Pro Thr 
        195                 200                 205             


Leu Ala Pro Leu Ile Gln Asn Phe Thr Leu Arg Glu Leu Leu Tyr Pro 
    210                 215                 220                 


Asp Ile Gln Ala Lys Val Gln Ser Met Ser Thr Phe Tyr Leu Ala Pro 
225                 230                 235                 240 


Lys 
    


<210>  226
<211>  243
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  226

Lys Lys Leu Ile Ile Ala Gly Thr Gly Ile Lys Phe Leu Ser His Leu 
1               5                   10                  15      


Thr Ile Glu Val Lys Ser Ala Ile Glu Thr Ser Cys Cys Val Val Phe 
            20                  25                  30          


Leu Leu Asn Glu Pro Ala Met Lys Asn Trp Val Val Lys Asn Ala Lys 
        35                  40                  45              


Lys Tyr Val Ser Leu Asp Asp Ile Tyr Phe Ser Ser Glu Gln Arg Ser 
    50                  55                  60                  


Glu Ser Tyr Asp Lys Ile Ala Asn Glu Leu Leu Ser Thr Ile Gln Lys 
65                  70                  75                  80  


Asn Asp Asp Val Cys Phe Leu Ile Tyr Gly His Pro Thr Phe Phe Ser 
                85                  90                  95      


Ser Val Val Glu Lys Ile Lys Lys Ile Ile Ser Ser Glu Asp Ile Ile 
            100                 105                 110         


Ile Gln Ile Met Pro Gly Ile Ser Ala Met Asp Cys Leu Phe Ala Asp 
        115                 120                 125             


Leu Lys Ile Asp Pro Gly Ser Met Gly Leu Gln Ser Tyr Asp Ala Thr 
    130                 135                 140                 


Glu Phe Leu Leu Tyr Asp Glu Asn Phe Ser Thr Thr Ser His Leu Val 
145                 150                 155                 160 


Leu Trp Gln Ile Ala Ile Ile Gly Glu Ile Gly Val Val Asn Asn Asn 
                165                 170                 175     


Glu Ile Asn Leu Asp Arg Gln Lys Lys Ala Ile Thr Ile Leu Ile Lys 
            180                 185                 190         


Lys Leu Leu Ile His Tyr Pro Ala Asp His Ile Val Tyr Leu Tyr Val 
        195                 200                 205             


Ala Ser Gln Tyr Pro Ser Ile Glu Phe Glu Leu Val Ser Ile Asp Leu 
    210                 215                 220                 


Gln Lys Leu Thr Glu Ile Asn Ile Ser Arg Leu Ala Thr Leu Tyr Ile 
225                 230                 235                 240 


Pro Pro Val 
            


<210>  227
<211>  207
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  227

Tyr Leu Val Asn Glu Pro Ile Thr Lys Gln Trp Ile Glu Arg Tyr Ser 
1               5                   10                  15      


Lys Leu Ser Glu Ser Leu Asp Pro Ile Tyr Phe Ala Glu Asn Asp Arg 
            20                  25                  30          


Gln Ile Ser Tyr Asp Lys Ile Arg Asp Lys Ile Leu Thr Glu Leu Glu 
        35                  40                  45              


Thr His Asn Phe Ile Thr Val Val Leu Tyr Gly His Pro Thr Val Phe 
    50                  55                  60                  


Ala Asp Pro Gly Leu Gln Ser Ile Ile Ile Ala Gln Lys Lys Ser Ile 
65                  70                  75                  80  


Glu Thr Ile Val Leu Pro Gly Ile Ser Val Glu Asn Cys Leu Tyr Ala 
                85                  90                  95      


Asp Leu Lys Ile Asp Pro Gly Gln Phe Gly Cys Phe His Val Glu Ala 
            100                 105                 110         


Thr Glu Leu Leu Leu Tyr Asp Lys Ile Ile Asp Pro Thr Val His Leu 
        115                 120                 125             


Cys Ile Trp Gln Pro Gly Met Ile Gly Asn Arg Ser Val Pro Lys Pro 
    130                 135                 140                 


Asn Gln Lys Ser Asn His Leu Glu Leu Leu Arg Ile Lys Leu Lys Lys 
145                 150                 155                 160 


Tyr Tyr Pro Asp Asp His Ile Ser Ile Leu Tyr Glu Ala Ser Met Tyr 
                165                 170                 175     


Pro Gly Val Glu Pro Ile Ile His Lys Phe Pro Leu Tyr Asp Ile Glu 
            180                 185                 190         


Asp Gln Asn Ile Gly Thr Leu Ser Thr Leu Tyr Ile Pro Pro Leu 
        195                 200                 205         


<210>  228
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  228

Gly Ser Leu Ala Ile Val Gly Thr Gly Ile Gln Ala Leu Gly His Leu 
1               5                   10                  15      


Thr Arg Glu Ala Glu Gly His Ile Arg His Ala Asp Val Val Phe His 
            20                  25                  30          


Cys Ile Arg Asp Pro Leu Met Leu Ala Asp Leu His Ala Leu Asn Pro 
        35                  40                  45              


Asn Val Ile Asp Leu Thr Thr Leu Tyr Gly Ala Asp Lys Arg Arg Ser 
    50                  55                  60                  


Leu Thr Tyr Val Gln Met Ala Glu Val Met Val Ala Glu Val Arg Ser 
65                  70                  75                  80  


Gly Arg Arg Val Thr Gly Val Phe Tyr Gly His Pro Gly Phe Tyr Val 
                85                  90                  95      


Ala Pro Ala Arg Leu Ala Leu Thr Thr Ala Lys Ala Glu Gly Tyr Asp 
            100                 105                 110         


Thr Cys Leu Leu Pro Gly Val Ser Ser Leu Asp Tyr Leu Phe Ala Asp 
        115                 120                 125             


Leu Arg Val Asp Pro Ser Gln Ser Gly Tyr Gln Ala Met Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Leu Arg Asn Arg Pro Leu Val Thr Ser Gly His Val Val 
145                 150                 155                 160 


Leu Met Gln Val Gly Pro Val Gly Asp Leu Phe Arg Pro Val Thr Asp 
                165                 170                 175     


Asn Leu Glu Arg Arg Ala Ile Leu Phe Glu Arg Leu Ile Glu Ile Tyr 
            180                 185                 190         


Gly Glu Asn His Pro Cys Val Asp Tyr Val Gly Ala Thr Arg Pro Gly 
        195                 200                 205             


Gln Lys Pro Val Leu Arg Arg Leu Lys Leu Gly Ala Tyr Arg Asp Pro 
    210                 215                 220                 


Ala Asn Leu Lys Arg Leu Ser Lys Ala Ser Thr Leu Tyr Ile Pro Pro 
225                 230                 235                 240 


Lys 
    


<210>  229
<211>  241
<212>  PRT
<213>  Fungal alpha-N-methyltransferase domain shown in FIG. 2A

<400>  229

Gly Arg Leu Val Val Ile Gly Ser Gly Ile Lys Ala Val Ser His Phe 
1               5                   10                  15      


Thr Leu Glu Ala Gln Ala His Ile Gln Gln Ala Asp Ile Val Leu Tyr 
            20                  25                  30          


Ala Ala Ala Asp Pro Val Thr Asp Met Trp Ile Glu Ser Gln Asn Pro 
        35                  40                  45              


Asn Ala Phe Asp Leu Tyr Gln Tyr Tyr Ala Asp Asp Lys Ala Arg Leu 
    50                  55                  60                  


Ile Thr Tyr Val Gln Met Ile Glu Arg Ile Met Ala Glu Val Arg Ala 
65                  70                  75                  80  


Gly Lys Tyr Val Cys Ala Leu Phe Tyr Gly His Pro Gly Val Phe Val 
                85                  90                  95      


Thr Pro Ser His Asn Ala Ile Ala Ile Ala Arg Gln Glu Gly Phe Asp 
            100                 105                 110         


Ala Val Met Leu Pro Ala Val Ser Ala Glu Asp Cys Leu Tyr Ala Asp 
        115                 120                 125             


Leu Gly Val Asp Pro Ser Val Pro Gly Met Gln Ile Tyr Glu Ala Thr 
    130                 135                 140                 


Asp Phe Leu Leu Arg Arg Arg Lys Val Asp Thr Thr Ala Asn Phe Val 
145                 150                 155                 160 


Leu Trp Gln Val Gly Cys Ile Gly Asp Leu Gly Phe Lys Phe Gly Gly 
                165                 170                 175     


Tyr Lys Asn Asp Lys Phe Asp Val Leu Leu Asp Tyr Leu Glu Glu Ile 
            180                 185                 190         


Tyr Gly Ala Asp His Pro Ala Ile Asn Tyr Val Ala Asn Met Phe Ser 
        195                 200                 205             


Gly Pro Pro Gln Ile Asp Arg His Val Ile Gly Asp Tyr Arg Asp Pro 
    210                 215                 220                 


Glu Val Lys Ala Lys Val Ser Gly Ile Ser Thr Phe Phe Ile Pro Ala 
225                 230                 235                 240 


Lys 
    


