                         SEQUENCE LISTING

<110>  INTERNATIONAL AIDS VACCINE INITIATIVE INC.
 
<120>  VACCINE COMPOSITIONS FOR PREVENTING CORONAVIRUS DISEASE

<130>  01281-0001-00PCT

<140>  PCT/US2021/018869
<141>  2021-02-19

<150>  US 62/979,949
<151>  2020-02-21

<150>  US 62/989,128
<151>  2020-03-13

<150>  US 63/005,717
<151>  2020-04-06

<150>  US 63/079,944
<151>  2020-09-17

<150>  US 63/143,522
<151>  2021-01-29

<160>  194   

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 1: wt S protein amino acid sequence

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  3846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 1: nucleotide sequence of wt S protein to be
       added to Vector A

<400>  2
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgtg     3720

ttgtatgaca tcgtgctgct catgcctcaa gggatgttgt agctgtggat cttgttgcaa     3780

gttcgatgag gatgattcag aaccagtttt aaaaggagta aagttgcatt acacataaag     3840

gctagc                                                                3846


<210>  3
<211>  3987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 1: nucleotide sequence of wt S protein to be
       added to Vector B

<400>  3
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgtgt tgtatgacat cgtgctgctc atgcctcaag ggatgttgta gctgtggatc     3840

ttgttgcaag ttcgatgagg atgattcaga accagtttta aaaggagtaa agttgcatta     3900

cacataaagc tcaaatcctg cacaacagat tcttcatgtt tgaaccaaat caacttgtga     3960

tatcatgctc aaagaggcct taattaa                                         3987


<210>  4
<211>  1242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 2: S protein with CT deletion

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser 
    1235                 1240         


<210>  5
<211>  3753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 2: nucleotide sequence of S protein with CT 
       deletion to be added to Vector A

<400>  5
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgtg     3720

ttgtatgaca tcgtgctgct cataaaggct agc                                  3753


<210>  6
<211>  3894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 2: nucleotide sequence of S protein with CT 
       deletion to be added to Vector B

<400>  6
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgtgt tgtatgacat cgtgctgctc ataaagctca aatcctgcac aacagattct     3840

tcatgtttga accaaatcaa cttgtgatat catgctcaaa gaggccttaa ttaa           3894


<210>  7
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 3: S protein with VSVG-CT IND serotype

<400>  7

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Arg  Val Gly Ile Tyr Leu  Cys Ile Lys Leu Lys  His Thr Lys 
    1235                 1240                 1245             


Lys Arg  Gln Ile Tyr Thr Asp  Ile Glu Met Asn Arg  Leu Gly Lys 
    1250                 1255                 1260             


<210>  8
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 3: nucleotide sequence of S protein with 
       VSVG-CT IND serotype to be added to Vector A

<400>  8
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgcg     3720

agttggtatt tatctttgca ttaaattaaa gcacaccaag aaaagacaga tttatacaga     3780

catagagatg aaccgacttg gaaagtaaag gctagc                               3816


<210>  9
<211>  3957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 3: nucleotide sequence of S protein with 
       VSVG-CT IND serotype to Vector B

<400>  9
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgcga gttggtattt atctttgcat taaattaaag cacaccaaga aaagacagat     3840

ttatacagac atagagatga accgacttgg aaagtaaagc tcaaatcctg cacaacagat     3900

tcttcatgtt tgaaccaaat caacttgtga tatcatgctc aaagaggcct taattaa        3957


<210>  10
<211>  1266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 4: S protein with VSVG-TM-CT IND serotype

<400>  10

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Ser 
    1205                 1210                 1215             


Ser Ile  Ala Ser Phe Phe Phe  Ile Ile Gly Leu Ile  Ile Gly Leu 
    1220                 1225                 1230             


Phe Leu  Val Leu Arg Val Gly  Ile Tyr Leu Cys Ile  Lys Leu Lys 
    1235                 1240                 1245             


His Thr  Lys Lys Arg Gln Ile  Tyr Thr Asp Ile Glu  Met Asn Arg 
    1250                 1255                 1260             


Leu Gly  Lys 
    1265     


<210>  11
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 4: nucleotide sequence of S protein with 
       VSVG-TM-CT IND serotype to be added to Vector A

<400>  11
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggagc tctattgcct cttttttctt tatcataggg ttaatcattg gactattctt     3720

ggttctccga gttggtattt atctttgcat taaattaaag cacaccaaga aaagacagat     3780

ttatacagac atagagatga accgacttgg aaagtaaagg ctagc                     3825


<210>  12
<211>  3966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 4: nucleotide sequence of S protein with 
       VSVG-TM-CT IND serotype to be added to Vector B

<400>  12
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggagct ctattgcctc ttttttcttt atcatagggt taatcattgg     3780

actattcttg gttctccgag ttggtattta tctttgcatt aaattaaagc acaccaagaa     3840

aagacagatt tatacagaca tagagatgaa ccgacttgga aagtaaagct caaatcctgc     3900

acaacagatt cttcatgttt gaaccaaatc aacttgtgat atcatgctca aagaggcctt     3960

aattaa                                                                3966


<210>  13
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 5: S protein with MPER6aa and VSVG-TM-CT IND
       serotype

<400>  13

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Ser Ser Ile Ala  Ser Phe Phe 
    1205                 1210                 1215             


Phe Ile  Ile Gly Leu Ile Ile  Gly Leu Phe Leu Val  Leu Arg Val 
    1220                 1225                 1230             


Gly Ile  Tyr Leu Cys Ile Lys  Leu Lys His Thr Lys  Lys Arg Gln 
    1235                 1240                 1245             


Ile Tyr  Thr Asp Ile Glu Met  Asn Arg Leu Gly Lys  
    1250                 1255                 1260 


<210>  14
<211>  3807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 5: nucleotide sequence of S protein with 
       MPER6aa and VSVG-TM-CT IND serotype

<400>  14
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaaa gctctattgc     3660

ctcttttttc tttatcatag ggttaatcat tggactattc ttggttctcc gagttggtat     3720

ttatctttgc attaaattaa agcacaccaa gaaaagacag atttatacag acatagagat     3780

gaaccgactt ggaaagtaaa ggctagc                                         3807


<210>  15
<211>  3948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 5: nucleotide sequence of S protein with 
       MPER6aa and VSVG-TM-CT IND serotype

<400>  15
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaaag     3720

ctctattgcc tcttttttct ttatcatagg gttaatcatt ggactattct tggttctccg     3780

agttggtatt tatctttgca ttaaattaaa gcacaccaag aaaagacaga tttatacaga     3840

catagagatg aaccgacttg gaaagtaaag ctcaaatcct gcacaacaga ttcttcatgt     3900

ttgaaccaaa tcaacttgtg atatcatgct caaagaggcc ttaattaa                  3948


<210>  16
<211>  1252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 6: S protein with dCt21

<400>  16

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser 
    1250         


<210>  17
<211>  3783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 6: Nucleotide sequence of S protein with 
       dCt21 to be added Vector A

<400>  17
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgtg     3720

ttgtatgaca tcgtgctgct catgcctcaa gggatgttgt agctgtggat cttaaaggct     3780

agc                                                                   3783


<210>  18
<211>  3924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 6: Nucleotide sequence of S protein with 
       dCt21 to be added Vector B

<400>  18
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgtgt tgtatgacat cgtgctgctc atgcctcaag ggatgttgta gctgtggatc     3840

ttaaagctca aatcctgcac aacagattct tcatgtttga accaaatcaa cttgtgatat     3900

catgctcaaa gaggccttaa ttaa                                            3924


<210>  19
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 7: S protein with dCt19 and VSVGct

<400>  19

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Arg  Val Gly Ile Tyr Leu  Cys Ile Lys 
    1250                 1255                 1260             


Leu Lys  His Thr Lys Lys Arg  Gln Ile Tyr Thr Asp  Ile Glu Met 
    1265                 1270                 1275             


Asn Arg  Leu Gly Lys 
    1280             


<210>  20
<211>  3876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 7: Nucleotide sequence of S protein with 
       dCt19 and VSGct to be added Vector A

<400>  20
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgtg     3720

ttgtatgaca tcgtgctgct catgcctcaa gggatgttgt agctgtggat cttgttgccg     3780

agttggtatt tatctttgca ttaaattaaa gcacaccaag aaaagacaga tttatacaga     3840

catagagatg aaccgacttg gaaagtaaag gctagc                               3876


<210>  21
<211>  4017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 7: Nucleotide sequence of S protein with 
       dCt19 and VSGct to be added Vector B

<400>  21
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgtgt tgtatgacat cgtgctgctc atgcctcaag ggatgttgta gctgtggatc     3840

ttgttgccga gttggtattt atctttgcat taaattaaag cacaccaaga aaagacagat     3900

ttatacagac atagagatga accgacttgg aaagtaaagc tcaaatcctg cacaacagat     3960

tcttcatgtt tgaaccaaat caacttgtga tatcatgctc aaagaggcct taattaa        4017


<210>  22
<211>  1275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 8: S protein with dCt19 and VSVGct21

<400>  22

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Leu Lys His Thr Lys  Lys Arg Gln 
    1250                 1255                 1260             


Ile Tyr  Thr Asp Ile Glu Met  Asn Arg Leu Gly Lys  
    1265                 1270                 1275 


<210>  23
<211>  3852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 8: Nucleotide sequence of S protein with 
       dCt19 and VSGct21 to be added Vector A

<400>  23
ctcgagagga gccaccatgt tcgtgttcct ggtgctatta cctctggttt cgtctcaatg       60

cgtaaacctt acaactagaa ctcagcttcc tccagcatac acaaattcct tcactcgcgg      120

agtgtattat cctgataagg tctttcgatc atcagtgttg cattccaccc aggatttgtt      180

tctcccgttc ttttcaaatg taacttggtt ccatgctata catgtttccg gaaccaatgg      240

aacaaagaga tttgataacc cagtgttacc atttaacgac ggagtttatt tcgcatcaac      300

tgagaaatcc aatatcatta gaggctggat tttcggaacg accctggatt ctaaaacgca      360

atccttgctg attgttaata atgcaacaaa tgtggtcatt aaagtctgtg aattccaatt      420

ttgcaatgat ccatttctcg gcgtctatta ccacaagaat aacaaatctt ggatggagtc      480

agagttcagg gtttatagtt ccgcaaataa ttgtactttt gaatacgttt cccaaccatt      540

cttaatggac ttggagggaa aacagggaaa ttttaagaat ctaagagaat tcgtctttaa      600

gaatattgat ggatatttca agatctattc aaaacataca cctataaacc tagttagaga      660

tctcccgcaa gggttttcag ccctagagcc actagttgac ctgccaattg ggatcaacat      720

tactagattc cagaccctac tcgctctgca tcggtcatat ttgacaccag gagattcatc      780

gtcaggatgg accgctggag cagctgctta ctatgttggg tatctgcaac ctagaacatt      840

tctcctaaag tataatgaaa acgggactat tacagacgca gtcgattgcg cactggatcc      900

actctcagag acaaagtgca ctctaaaatc attcactgtc gagaaaggaa tctatcaaac      960

atcaaatttc agggtccagc caactgagag tattgtccgg ttccctaaca taactaactt     1020

gtgccccttc ggagaggttt tcaatgctac tcggttcgcc agcgtctacg catggaacag     1080

aaagaggatt tcaaactgtg tcgcagatta tagcgtcctc tataattcag catcattcag     1140

tacatttaaa tgctatggtg tcagccccac caaacttaat gacttatgtt ttaccaatgt     1200

atatgcagat tcctttgtaa tcagaggtga cgaagtgagg caaatcgcac ctggacagac     1260

cggaaagatt gctgattata attataaact ccctgatgat tttaccggat gtgttattgc     1320

ttggaacagc aataacctcg atagtaaggt cggaggaaac tataactatt tgtacagact     1380

gtttagaaag tcgaatttga aaccttttga aagagacata tccaccgaga tttaccaggc     1440

gggcagcaca ccgtgtaatg gtgtagaagg attcaattgt tactttcccc tgcaatcata     1500

tgggtttcaa ccaaccaatg gagtcggata tcaaccatat cgtgtcgtcg tcctttcctt     1560

cgagctgctt catgcaccag ctacagtctg cggacctaag aagagcacta atcttgtcaa     1620

gaacaaatgt gtgaacttta attttaatgg attaacagga accggagttt tgaccgagag     1680

taataagaag ttcttgccgt tccagcaatt tggacgagac attgctgaca ccacagatgc     1740

ggttcgtgac ccgcaaactt tagagatcct agacatcacc ccatgttcat tcggtggagt     1800

ttccgttatt actcctggaa cgaatacaag caatcaagtt gccgttctct atcaagatgt     1860

taattgtaca gaagtgcctg tggccattca tgcagatcaa ctaacaccaa cttggagagt     1920

ttacagcact gggtccaatg tcttccaaac gcgcgccggc tgcctcattg gtgcagaaca     1980

tgtgaataac tcatacgaat gtgacattcc aatcggtgcc ggcatatgcg cctcttacca     2040

gactcagact aattcgccaa gaagagccag gtctgtcgca agtcagtcaa ttattgcata     2100

cacaatgtcg ttaggagcag agaatagtgt agcatactca aacaattcta tagcaatacc     2160

taccaacttc actatatcag taactacaga aatattgcca gtatccatga ctaaaacaag     2220

tgtggattgc accatgtaca tctgtggaga ttccacagaa tgcagcaatc ttctcttgca     2280

atacggatca ttctgcacac aactgaatag ggcactgact ggaattgcag tcgagcagga     2340

taagaacaca caggaggtgt ttgcccaagt caaacaaata tacaaaacac cacccatcaa     2400

ggattttgga ggatttaatt tctcacaaat actccccgac ccatccaagc cctccaaaag     2460

gagtttcatt gaggacctct tgtttaataa ggttaccttg gcagatgccg ggtttattaa     2520

gcagtacggc gactgtcttg gagacatagc agccagagat ctaatttgtg cccagaaatt     2580

caatggactg acagtcctgc ctcccttatt aactgatgag atgatagctc agtatacatc     2640

agcattgttg gctggtacaa ttacatctgg atggacattt ggtgccggag cggcattaca     2700

aatccctttt gcaatgcaaa tggcctatag atttaatgga atcggagtaa ctcaaaatgt     2760

tttatatgag aatcagaaat taattgcaaa tcaattcaat tcagctatag gaaagattca     2820

ggattcactc agtagtacag caagcgctct aggcaaatta caagacgtcg tcaatcagaa     2880

tgcacaggca ttaaatacac tggtgaagca attgagttcc aatttcggag caatttcatc     2940

tgttctaaat gatatattgt caagactgga taaagtagaa gccgaggtcc aaatcgatag     3000

gctgatcaca ggaagacttc aatcactaca gacatacgtc acccaacaac tcatcagagc     3060

agcagaaatt agagcctctg ctaatctagc cgcaacaaag atgtcagagt gcgtattggg     3120

acaatctaag agggtcgact tttgtggaaa ggggtatcac ttgatgtcct ttcctcaatc     3180

tgcaccacac ggagttgtct tcttacatgt aacatatgtg cccgctcaag aaaagaattt     3240

cactacagca cctgcaatat gtcatgacgg aaaagcacat tttcctcggg agggagtttt     3300

cgtttctaat ggaacccatt ggttcgtgac ccaaaggaac ttttacgagc ctcaaataat     3360

tacaactgat aatacattcg tttctggaaa ttgcgacgta gttataggta ttgtaaataa     3420

tactgtttat gaccctttac aacctgaact cgattccttc aaggaagaac tcgacaaata     3480

ttttaagaat cacacctcac cggacgttga cttaggagac atttccggga ttaacgctag     3540

tgtagtcaat atccaaaagg agatagatag actgaatgag gtagcaaaga atcttaatga     3600

atctttgatc gaccttcagg agctggggaa gtacgaacaa tacataaaat ggccatggta     3660

catttggctc gggtttattg ctggactaat tgcaatagtc atggtcacta tcatgctgtg     3720

ttgtatgaca tcgtgctgct catgcctcaa gggatgttgt agctgtggat cttgttgcaa     3780

attaaagcac accaagaaaa gacagattta tacagacata gagatgaacc gacttggaaa     3840

gtaaaggcta gc                                                         3852


<210>  24
<211>  3993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Construct 8: Nucleotide sequence of S protein with 
       dCt19 and VSGct21 to be added Vector B

<400>  24
ttcgaacaac taatatcctg tcttctctat ccctatgaaa aaaactaaca gagatcgatc       60

tgtttccttg acaccaggag ccaccatgtt cgtgttcctg gtgctattac ctctggtttc      120

gtctcaatgc gtaaacctta caactagaac tcagcttcct ccagcataca caaattcctt      180

cactcgcgga gtgtattatc ctgataaggt ctttcgatca tcagtgttgc attccaccca      240

ggatttgttt ctcccgttct tttcaaatgt aacttggttc catgctatac atgtttccgg      300

aaccaatgga acaaagagat ttgataaccc agtgttacca tttaacgacg gagtttattt      360

cgcatcaact gagaaatcca atatcattag aggctggatt ttcggaacga ccctggattc      420

taaaacgcaa tccttgctga ttgttaataa tgcaacaaat gtggtcatta aagtctgtga      480

attccaattt tgcaatgatc catttctcgg cgtctattac cacaagaata acaaatcttg      540

gatggagtca gagttcaggg tttatagttc cgcaaataat tgtacttttg aatacgtttc      600

ccaaccattc ttaatggact tggagggaaa acagggaaat tttaagaatc taagagaatt      660

cgtctttaag aatattgatg gatatttcaa gatctattca aaacatacac ctataaacct      720

agttagagat ctcccgcaag ggttttcagc cctagagcca ctagttgacc tgccaattgg      780

gatcaacatt actagattcc agaccctact cgctctgcat cggtcatatt tgacaccagg      840

agattcatcg tcaggatgga ccgctggagc agctgcttac tatgttgggt atctgcaacc      900

tagaacattt ctcctaaagt ataatgaaaa cgggactatt acagacgcag tcgattgcgc      960

actggatcca ctctcagaga caaagtgcac tctaaaatca ttcactgtcg agaaaggaat     1020

ctatcaaaca tcaaatttca gggtccagcc aactgagagt attgtccggt tccctaacat     1080

aactaacttg tgccccttcg gagaggtttt caatgctact cggttcgcca gcgtctacgc     1140

atggaacaga aagaggattt caaactgtgt cgcagattat agcgtcctct ataattcagc     1200

atcattcagt acatttaaat gctatggtgt cagccccacc aaacttaatg acttatgttt     1260

taccaatgta tatgcagatt cctttgtaat cagaggtgac gaagtgaggc aaatcgcacc     1320

tggacagacc ggaaagattg ctgattataa ttataaactc cctgatgatt ttaccggatg     1380

tgttattgct tggaacagca ataacctcga tagtaaggtc ggaggaaact ataactattt     1440

gtacagactg tttagaaagt cgaatttgaa accttttgaa agagacatat ccaccgagat     1500

ttaccaggcg ggcagcacac cgtgtaatgg tgtagaagga ttcaattgtt actttcccct     1560

gcaatcatat gggtttcaac caaccaatgg agtcggatat caaccatatc gtgtcgtcgt     1620

cctttccttc gagctgcttc atgcaccagc tacagtctgc ggacctaaga agagcactaa     1680

tcttgtcaag aacaaatgtg tgaactttaa ttttaatgga ttaacaggaa ccggagtttt     1740

gaccgagagt aataagaagt tcttgccgtt ccagcaattt ggacgagaca ttgctgacac     1800

cacagatgcg gttcgtgacc cgcaaacttt agagatccta gacatcaccc catgttcatt     1860

cggtggagtt tccgttatta ctcctggaac gaatacaagc aatcaagttg ccgttctcta     1920

tcaagatgtt aattgtacag aagtgcctgt ggccattcat gcagatcaac taacaccaac     1980

ttggagagtt tacagcactg ggtccaatgt cttccaaacg cgcgccggct gcctcattgg     2040

tgcagaacat gtgaataact catacgaatg tgacattcca atcggtgccg gcatatgcgc     2100

ctcttaccag actcagacta attcgccaag aagagccagg tctgtcgcaa gtcagtcaat     2160

tattgcatac acaatgtcgt taggagcaga gaatagtgta gcatactcaa acaattctat     2220

agcaatacct accaacttca ctatatcagt aactacagaa atattgccag tatccatgac     2280

taaaacaagt gtggattgca ccatgtacat ctgtggagat tccacagaat gcagcaatct     2340

tctcttgcaa tacggatcat tctgcacaca actgaatagg gcactgactg gaattgcagt     2400

cgagcaggat aagaacacac aggaggtgtt tgcccaagtc aaacaaatat acaaaacacc     2460

acccatcaag gattttggag gatttaattt ctcacaaata ctccccgacc catccaagcc     2520

ctccaaaagg agtttcattg aggacctctt gtttaataag gttaccttgg cagatgccgg     2580

gtttattaag cagtacggcg actgtcttgg agacatagca gccagagatc taatttgtgc     2640

ccagaaattc aatggactga cagtcctgcc tcccttatta actgatgaga tgatagctca     2700

gtatacatca gcattgttgg ctggtacaat tacatctgga tggacatttg gtgccggagc     2760

ggcattacaa atcccttttg caatgcaaat ggcctataga tttaatggaa tcggagtaac     2820

tcaaaatgtt ttatatgaga atcagaaatt aattgcaaat caattcaatt cagctatagg     2880

aaagattcag gattcactca gtagtacagc aagcgctcta ggcaaattac aagacgtcgt     2940

caatcagaat gcacaggcat taaatacact ggtgaagcaa ttgagttcca atttcggagc     3000

aatttcatct gttctaaatg atatattgtc aagactggat aaagtagaag ccgaggtcca     3060

aatcgatagg ctgatcacag gaagacttca atcactacag acatacgtca cccaacaact     3120

catcagagca gcagaaatta gagcctctgc taatctagcc gcaacaaaga tgtcagagtg     3180

cgtattggga caatctaaga gggtcgactt ttgtggaaag gggtatcact tgatgtcctt     3240

tcctcaatct gcaccacacg gagttgtctt cttacatgta acatatgtgc ccgctcaaga     3300

aaagaatttc actacagcac ctgcaatatg tcatgacgga aaagcacatt ttcctcggga     3360

gggagttttc gtttctaatg gaacccattg gttcgtgacc caaaggaact tttacgagcc     3420

tcaaataatt acaactgata atacattcgt ttctggaaat tgcgacgtag ttataggtat     3480

tgtaaataat actgtttatg accctttaca acctgaactc gattccttca aggaagaact     3540

cgacaaatat tttaagaatc acacctcacc ggacgttgac ttaggagaca tttccgggat     3600

taacgctagt gtagtcaata tccaaaagga gatagataga ctgaatgagg tagcaaagaa     3660

tcttaatgaa tctttgatcg accttcagga gctggggaag tacgaacaat acataaaatg     3720

gccatggtac atttggctcg ggtttattgc tggactaatt gcaatagtca tggtcactat     3780

catgctgtgt tgtatgacat cgtgctgctc atgcctcaag ggatgttgta gctgtggatc     3840

ttgttgcaaa ttaaagcaca ccaagaaaag acagatttat acagacatag agatgaaccg     3900

acttggaaag taaagctcaa atcctgcaca acagattctt catgtttgaa ccaaatcaac     3960

ttgtgatatc atgctcaaag aggccttaat taa                                  3993


<210>  25
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHW06059 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  25

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


Tyr Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  26
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ00379 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  26

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Trp Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  27
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR84449 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  27

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Arg Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  28
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QIA20044 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  28

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Asn Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  29
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ00358 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  29

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  30
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  dbj_BCA25664 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  31
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ87582 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  31

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  32
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  dbj_BCA25674 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  32

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  33
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ00389 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  33

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  34
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ87592 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  34

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  35
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QIB84673 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  35

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  36
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR63260 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  36

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  37
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QIA98606 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  37

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  38
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QIA98596 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  38

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  39
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR63250 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  39

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  40
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR63280 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  40

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  41
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR63290 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  41

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  42
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHR63270 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  42

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  43
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHZ00399 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  43

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  44
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  dbj_BCA25644 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  44

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  45
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  dbj_BCA25654 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  45

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  46
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHO62877 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  46

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  47
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  ref_YP_00972439 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  47

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  48
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHW06039 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  48

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  49
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHO62112 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  49

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  50
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHQ71973 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  50

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  51
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHW06049 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  51

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  52
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHO60594 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  52

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  53
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHN73810 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  53

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  54
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHO62107 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  54

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  55
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHQ82464 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  55

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  56
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  dbj_BBW89517 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  56

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  57
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU79204 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  57

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  58
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHQ71963 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  58

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  59
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU79194 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  59

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  60
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHN73795 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  60

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  61
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU36864 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  61

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  62
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHD43416 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  62

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  63
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU36854 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  63

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  64
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU36844 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  64

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  65
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU36834 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  65

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  66
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  gb_QHU36824 (a full-length SARS-CoV-2 S protein amino acid 
       variant sequence)

<400>  66

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  67
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  SITE
<222>  (1)..(1273)
<223>  Consensus sequence

<400>  67

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  68
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 1gVSVLeader_f (primer used for the Sanger sequencing 
       of the rVSV-delta-G-SARS-CoV-2 genome)

<400>  68
acgaagacaa acaaaccatt attatcatta aaagg                                  35


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2gVSV_400f (primer used for the Sanger sequencing of 
       the rVSV-delta-G-SARS-CoV-2 genome)

<400>  69
agcaggggat acaatcggaa ta                                                22


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3gVSV_800f

<400>  70
cacctctgca aaataaccgg aa                                                22


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 4gVSV_1200f

<400>  71
gcagagatgt ggtcgaatgg c                                                 21


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5gVSV_1600f

<400>  72
tgaaggcttt atacaggggc                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 6gVSV_200r

<400>  73
tggtagacat atcctcttag                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 7gVSV_400r

<400>  74
gctggttctg gaagcatccg                                                   20


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 8gVSV_800r

<400>  75
ctggaagcat catttggacc attt                                              24


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 9gVSV_1200r

<400>  76
gctcttttcg catactgcat cata                                              24


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 10gVSV_1600r

<400>  77
ccacttcctc atctgcatag tcat                                              24


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 11gVSV_1200f

<400>  78
gcagagatgt ggtcgaatgg c                                                 21


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 12gVSV_1600f

<400>  79
tgaaggcttt atacaggggc                                                   20


<210>  80
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 13gVSV_2000f

<400>  80
tccatgactt tccaacccaa ga                                                22


<210>  81
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 14gVSV_2400f

<400>  81
cgagatggac acctatgatc cgaa                                              24


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 15gVSV_1200r

<400>  82
gctcttttcg catactgcat cata                                              24


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 16gVSV_1600r

<400>  83
ccacttcctc atctgcatag tcat                                              24


<210>  84
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 17gVSV_2000r

<400>  84
ctccgacaga gatgaactct cctc                                              24


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 18gVSV_2400r

<400>  85
gctgccacat ctgagtatgt tctg                                              24


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 19gVSV_2000f

<400>  86
tccatgactt tccaacccaa ga                                                22


<210>  87
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 20gVSV_2400f

<400>  87
cgagatggac acctatgatc cgaa                                              24


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 21gVSV_2800f2

<400>  88
ctacgatgat gagtcactgg                                                   20


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 22gVSV_2400r

<400>  89
gctgccacat ctgagtatgt tctg                                              24


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 23gVSV_2800r

<400>  90
cctttttctc gacaatcagg cc                                                22


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 24CoV_S_rvs1

<400>  91
ctctttgttc cattggttcc                                                   20


<210>  92
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 25gVSV_2400f

<400>  92
cgagatggac acctatgatc cgaa                                              24


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26CoV_S_fw1

<400>  93
agtggatcct actcgagagg                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 27CoV_S_fw2

<400>  94
cattaaagtc tgtgaattcc                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 28CoV_S_fw3

<400>  95
agcagctgct tactatgttg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 29CoV_S_fw4

<400>  96
gtatatgcag attcctttgt                                                   20


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 30CoV_S_fw5

<400>  97
acctaagaag agcactaatc t                                                 21


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 31CoV_S_rvs1

<400>  98
ctctttgttc cattggttcc                                                   20


<210>  99
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 32CoV_S_rvs2

<400>  99
gatctctaac taggtttata ggtgt                                             25


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 33CoV_S_rvs3

<400>  100
agtagcattg aaaacctctc                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 34CoV_S_rvs4

<400>  101
cattacacgg tgtgctgccc                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 35CoV_S_rvs5

<400>  102
gatagagaac ggcaacttga                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 36CoV_S_rvs6

<400>  103
ggaatctcca cagatgtaca                                                   20


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 37CoV_S_fw5

<400>  104
acctaagaag agcactaatc t                                                 21


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 38CoV_S_fw6

<400>  105
tgacattcca atcggtgccg                                                   20


<210>  106
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 39CoV_S_fw7

<400>  106
ccatcaagga ttttggagga tttaa                                             25


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 40CoV_S_fw8

<400>  107
gctataggaa agattcagga                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 41CoV_S_fw9

<400>  108
acatgtaaca tatgtgcccg                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 42CoV_S_fw10

<400>  109
tgatcgacct tcaggagctg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 43CoV_S_rvs7

<400>  110
tgtaattgta ccagccaaca                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 44CoV_S_rvs8

<400>  111
tgatgagttg ttgggtgacg                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 45CoV_S_rvs9

<400>  112
ggaatcgagt tcaggttgta                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 46CoV_S_rvs10

<400>  113
aacgcgtaaa cagctagcct                                                   20


<210>  114
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 47gVSVGene4_f

<400>  114
ttaatgtttg gcctgattgt cgaga                                             25


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 48gVSVGene4_rev

<400>  115
gcgctcatcg ggattcagga a                                                 21


<210>  116
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 49gVSV_4800r

<400>  116
ccaccacgtc aaatgttatt tc                                                22


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 50CoV_S_fw10

<400>  117
acatgtaaca tatgtgcccg                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 51gVSV_5300f

<400>  118
gggcaacaaa ccaattgaat                                                   20


<210>  119
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 52gVSV_5800f

<400>  119
gcaagagaat caaggccttt agt                                               23


<210>  120
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 53gVSV_6300f

<400>  120
cccatcgata atatactctg acaaa                                             25


<210>  121
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 54gVSV_6800f

<400>  121
tccttaatcg agagaactca tgaa                                              24


<210>  122
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 55gVSV_4800r

<400>  122
ccaccacgtc aaatgttatt tc                                                22


<210>  123
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 56gVSV_5200r2

<400>  123
actaaaggcc ttgattctct tgc                                               23


<210>  124
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 57gVSV_5200r

<400>  124
gatgggtcta gtaagtcggg tatt                                              24


<210>  125
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 58gVSV_6200r2

<400>  125
ttcatgagtt ctctcgatta agga                                              24


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 59gVSV_6200r

<400>  126
cactcgtgac catctcttgg                                                   20


<210>  127
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 60gVSV_6300f

<400>  127
cccatcgata atatactctg acaaa                                             25


<210>  128
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 61gVSV_6800f

<400>  128
tccttaatcg agagaactca tgaa                                              24


<210>  129
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 62gVSV_7300f

<400>  129
tgaccaaata cccacttgtg c                                                 21


<210>  130
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 63gVSV_7800f

<400>  130
cgaacttgtt aaagactgag gttaa                                             25


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 64JKgVSV_8300f

<400>  131
cgggatccat gacgtcttta                                                   20


<210>  132
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 65gVSV_8800f

<400>  132
tttgagaccc atagaagaga tcac                                              24


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 66gVSV_6200r

<400>  133
cactcgtgac catctcttgg                                                   20


<210>  134
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 67gVSV_7200r2

<400>  134
ttaacctcag tctttaacaa gttcg                                             25


<210>  135
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 68gVSV_7200r

<400>  135
tgaaccctga tgtgttacat gg                                                22


<210>  136
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 69gVSV_8200r2

<400>  136
gtgatctctt ctatgggtct caaa                                              24


<210>  137
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 70gVSV_8200r

<400>  137
tcgtttctaa ttcgtctcta atagg                                             25


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 71gVSV_8300f

<400>  138
cgggatccat gacgtcttta                                                   20


<210>  139
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 72gVSV_8800f

<400>  139
tttgagaccc atagaagaga tcac                                              24


<210>  140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 73gVSV_9300f

<400>  140
ctcctatccg acaagcaacc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 74gVSV_9800f

<400>  141
gaatcaggtt gggccaatta                                                   20


<210>  142
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 75gVSV_10300f

<400>  142
gagcgaaaag aatgcagtaa ca                                                22


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 76gVSV_10800f

<400>  143
gcttttggct gagtttgatg                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 77JKVSVGene6_f

<400>  144
aaacacagga atgattgaat                                                   20


<210>  145
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 78gVSV_8200r

<400>  145
tcgtttctaa ttcgtctcta atagg                                             25


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 79gVSV_9200r2

<400>  146
taattggccc aacctgattc                                                   20


<210>  147
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 80gVSV_9200r

<400>  147
cgctctcaca aatatatgtt ccata                                             25


<210>  148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 81gVSV_10200r2

<400>  148
catcaaactc agccaaaagc                                                   20


<210>  149
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 82JRVSVTrailer_r

<400>  149
acgaagacca caaaaccaga taaa                                              24


<210>  150
<211>  13440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence for rVSV-delta-G-SARS-CoV-2 clone 
       MB1

<400>  150
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat ctgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagattga     3060

tctgtttacg cgctagtgga tcctactcga gaggagccac catgttcgtg ttcctggtgc     3120

tattacctct ggtttcgtct caatgcgtaa accttacaac tagaactcag cttcctccag     3180

catacacaaa ttccttcact cgcggagtgt attatcctga taaggtcttt cgatcatcag     3240

tgttgcattc cacccaggat ttgtttctcc cgttcttttc aaatgtaact tggttccatg     3300

ctatacatgt ttccggaacc aatggaacaa agagatttga taacccagtg ttaccattta     3360

acgacggagt ttatttcgca tcaactgaga aatccaatat cattagaggc tggattttcg     3420

gaacgaccct ggattctaaa acgcaatcct tgctgattgt taataatgca acaaatgtgg     3480

tcattaaagt ctgtgaattc caattttgca atgatccatt tctcggcgtc tattaccaca     3540

agaataacaa atcttggatg gagtcagagt tcagggttta tagttccgca aataattgta     3600

cttttgaata cgtttcccaa ccattcttaa tggacttgga gggaaaacag ggaaatttta     3660

agaatctaag agaattcgtc tttaagaata ttgatggata tttcaagatc tattcaaaac     3720

atacacctat aaacctagtt agagatctcc cgcaagggtt ttcagcccta gagccactag     3780

ttgacctgcc aattgggatc aacattacta gattccagac cctactcgct ctgcatcggt     3840

catatttgac accaggagat tcatcgtcag gatggaccgc tggagcagct gcttactatg     3900

ttgggtatct gcaacctaga acatttctcc taaagtataa tgaaaacggg actattacag     3960

acgcagtcga ttgcgcactg gatccactct cagagacaaa gtgcactcta aaatcattca     4020

ctgtcgagaa aggaatctat caaacatcaa atttcagggt ccagccaact gagagtattg     4080

tccggttccc taacataact aacttgtgcc ccttcggaga ggttttcaat gctactcggt     4140

tcgccagcgt ctacgcatgg aacagaaaga ggatttcaaa ctgtgtcgca gattatagcg     4200

tcctctataa ttcagcatca ttcagtacat ttaaatgcta tggtgtcagc cccaccaaac     4260

ttaatgactt atgttttacc aatgtatatg cagattcctt tgtaatcaga ggtgacgaag     4320

tgaggcaaat cgcacctgga cagaccggaa agattgctga ttataattat aaactccctg     4380

atgattttac cggatgtgtt attgcttgga acagcaataa cctcgatagt aaggtcggag     4440

gaaactataa ctatttgtac agactgttta gaaagtcgaa tttgaaacct tttgaaagag     4500

acatatccac cgagatttac caggcgggca gcacaccgtg taatggtgta gaaggattca     4560

attgttactt tcccctgcaa tcatatgggt ttcaaccaac caatggagtc ggatatcaac     4620

catatcgtgt cgtcgtcctt tccttcgagc tgcttcatgc accagctaca gtctgcggac     4680

ctaagaagag cactaatctt gtcaagaaca aatgtgtgaa ctttaatttt aatggattaa     4740

caggaaccgg agttttgacc gagagtaata agaagttctt gccgttccag caatttggac     4800

gagacattgc tgacaccaca gatgcggttc gtgacccgca aactttagag atcctagaca     4860

tcaccccatg ttcattcggt ggagtttccg ttattactcc tggaacgaat acaagcaatc     4920

aagttgccgt tctctatcaa gatgttaatt gtacagaagt gcctgtggcc attcatgcag     4980

atcaactaac accaacttgg agagtttaca gcactgggtc caatgtcttc caaacgcgcg     5040

ccggctgcct cattggtgca gaacatgtga ataactcata cgaatgtgac attccaatcg     5100

gtgccggcat atgcgcctct taccagactc agactaattc gccaagagga gccaggtctg     5160

tcgcaagtca gtcaattatt gcatacacaa tgtcgttagg agcagagaat agtgtagcat     5220

actcaaacaa ttctatagca atacctacca acttcactat atcagtaact acagaaatat     5280

tgccagtatc catgactaaa acaagtgtgg attgcaccat gtacatctgt ggagattcca     5340

cagaatgcag caatcttctc ttgcaatacg gatcattctg cacacaactg aatagggcac     5400

tgactggaat tgcagtcgag caggataaga acacacagga ggtgtttgcc caagtcaaac     5460

aaatatacaa aacaccaccc atcaaggatt ttggaggatt taatttctca caaatactcc     5520

ccgacccatc caagcccttc aaaaggagtt tcattgagga cctcttgttt aataaggtta     5580

ccttggcaga tgccgggttt attaagcagt acggcgactg tcttggagac atagcagcca     5640

gagatctaat ttgtgcccag aaattcaatg gactgacagt cctgcctccc ttattaactg     5700

atgagatgat agctcagtat acatcagcat tgttggctgg tacaattaca tctggatgga     5760

catttggtgc cggagcggca ttacaaatcc cttttgcaat gcaaatggcc tatagattta     5820

atggaatcgg agtaactcaa aatgttttat atgagaatca gaaattaatt gcaaatcaat     5880

tcaattcagc tataggaaag attcaggatt cactcagtag tacagcaagc gctctaggca     5940

aattacaaga cgtcgtcaat cagaatgcac aggcattaaa tacactggtg aagcaattga     6000

gttccaattt cggagcaatt tcatctgttc taaatgatat attgtcaaga ctggataaag     6060

tagaagccga ggtccaaatc gataggctga tcacaggaag acttcaatca ctacagacat     6120

acgtcaccca acaactcatc agagcagcag aaattagagc ctctgctaat ctagccgcaa     6180

caaagatgtc agagtgcgta ttgggacaat ctaagagggt cgacttttgt ggaaaggggt     6240

atcacttgat gtcctttcct caatctgcac cacacggagt tgtcttctta catgtaacat     6300

atgtgcccgc tcaagaaaag aatttcacta cagcacctgc aatatgtcat gacggaaaag     6360

cacattttcc tcgggaggga gttttcgttt ctaatggaac ccattggttc gtgacccaaa     6420

ggaactttta cgagcctcaa ataattacaa ctgataatac attcgtttct ggaaattgcg     6480

acgtagttat aggtattgta aataatactg tttatgaccc tttacaacct gaactcgatt     6540

ccttcaagga agaactcgac aaatatttta agaatcacac ctcaccggac gttgacttag     6600

gagacatttc cgggattaac gctagtgtag tcaatatcca aaaggagata gatagactga     6660

atgaggtagc aaagaatctt aatgaatctt tgatcgacct tcaggagctg gggaagtacg     6720

aacaatacat aaaatggcca tggtacattt ggctcgggtt tattgctgga ctaattgcaa     6780

tagtcatggt cactatcatg ctgtgttgta tgacatcgtg ctgctcatgc ctcaagggat     6840

gttgtagctg ttgatcttgt tgcaagttcg atgaggatga ttcagaacca gttttaaaag     6900

gagtaaagtt gcattacaca taaaggctag ctgtttacgc gttatccatg ctcaaagagg     6960

cctcaattat atttgagttt ttaattttta tgaaaaaaac taacagcaat catggaagtc     7020

cacgattttg agaccgacga gttcaatgat ttcaatgaag atgactatgc cacaagagaa     7080

ttcctgaatc ccgatgagcg catgacgtac ttgaatcatg ctgattacaa cctgaattct     7140

cctctaatta gtgatgatat tgacaattta atcaggaaat tcaattctct tccaattccc     7200

tcgatgtggg atagtaagaa ctgggatgga gttcttgaga tgttaacgtc atgtcaagcc     7260

aatcccatcc caacatctca gatgcataaa tggatgggaa gttggttaat gtctgataat     7320

catgatgcca gtcaagggta tagtttttta catgaagtgg acaaagaggc agaaataaca     7380

tttgacgtgg tggagacctt catccgcggc tggggcaaca aaccaattga atacatcaaa     7440

aaggaaagat ggactgactc attcaaaatt ctcgcttatt tgtgtcaaaa gtttttggac     7500

ttacacaagt tgacattaat cttaaatgct gtctctgagg tggaattgct caacttggcg     7560

aggactttca aaggcaaagt cagaagaagt tctcatggaa cgaacatatg caggattagg     7620

gttcccagct tgggtcctac ttttatttca gaaggatggg cttacttcaa gaaacttgat     7680

attctaatgg accgaaactt tctgttaatg gtcaaagatg tgattatagg gaggatgcaa     7740

acggtgctat ccatggtatg tagaatagac aacctgttct cagagcaaga catcttctcc     7800

cttctaaata tctacagaat tggagataaa attgtggaga ggcagggaaa tttttcttat     7860

gacttgatta aaatggtgga accgatatgc aacttgaagc tgatgaaatt agcaagagaa     7920

tcaaggcctt tagtcccaca attccctcat tttgaaaatc atatcaagac ttctgttgat     7980

gaaggggcaa aaattgaccg aggtataaga ttcctccatg atcagataat gagtgtgaaa     8040

acagtggatc tcacactggt gatttatgga tcgttcagac attggggtca tccttttata     8100

gattattaca ctggactaga aaaattacat tcccaagtaa ccatgaagaa agatattgat     8160

gtgtcatatg caaaagcact tgcaagtgat ttagctcgga ttgttctatt tcaacagttc     8220

aatgatcata aaaagtggtt cgtgaatgga gacttgctcc ctcatgatca tccctttaaa     8280

agtcatgtta aagaaaatac atggcccaca gctgctcaag ttcaagattt tggagataaa     8340

tggcatgaac ttccgctgat taaatgtttt gaaatacccg acttactaga cccatcgata     8400

atatactctg acaaaagtca ttcaatgaat aggtcagagg tgttgaaaca tgtccgaatg     8460

aatccgaaca ctcctatccc tagtaaaaag gtgttgcaga ctatgttgga cacaaaggct     8520

accaattgga aagaatttct taaagagatt gatgagaagg gcttagatga tgatgatcta     8580

attattggtc ttaaaggaaa ggagagggaa ctgaagttgg caggtagatt tttctcccta     8640

atgtcttgga aattgcgaga atactttgta attaccgaat atttgataaa gactcatttc     8700

gtccctatgt ttaaaggcct gacaatggcg gacgatctaa ctgcagtcat taaaaagatg     8760

ttagattcct catccggcca aggattgaag tcatatgagg caatttgcat agccaatcac     8820

attgattacg aaaaatggaa taaccaccaa aggaagttat caaacggccc agtgttccga     8880

gttatgggcc agttcttagg ttatccatcc ttaatcgaga gaactcatga attttttgag     8940

aaaagtctta tatactacaa tggaagacca gacttgatgc gtgttcacaa caacacactg     9000

atcaattcaa cctcccaacg agtttgttgg caaggacaag agggtggact ggaaggtcta     9060

cggcaaaaag gatggagtat cctcaatcta ctggttattc aaagagaggc taaaatcaga     9120

aacactgctg tcaaagtctt ggcacaaggt gataatcaag ttatttgcac acagtataaa     9180

acgaagaaat cgagaaacgt tgtagaatta cagggtgctc tcaatcaaat ggtttctaat     9240

aatgagaaaa ttatgactgc aatcaaaata gggacaggga agttaggact tttgataaat     9300

gacgatgaga ctatgcaatc tgcagattac ttgaattatg gaaaaatacc gattttccgt     9360

ggagtgatta gagggttaga gaccaagaga tggtcacgag tgacttgtgt caccaatgac     9420

caaataccca cttgtgctaa tataatgagc tcagtttcca caaatgctct caccgtagct     9480

cattttgctg agaacccaat caatgccatg atacagtaca attattttgg gacatttgct     9540

agactcttgt tgatgatgca tgatcctgct cttcgtcaat cattgtatga agttcaagat     9600

aagataccag gcttgcacag ttctactttc aaatacgcca tgttgtattt ggacccttcc     9660

attggaggag tgtcgggcat gtctttgtcc aggtttttga ttagagcctt cccagatccc     9720

gtaacagaaa gtctctcatt ctggagattc atccatgtac atgctcgaag tgagcatctg     9780

aaggagatga gtgcagtatt tggaaacccc gagatagcca agtttcgaat aactcacata     9840

gacaagctag tagaagatcc aacctctctg aacatcgcta tgggaatgag tccagcgaac     9900

ttgttaaaga ctgaggttaa aaaatgctta atcgaatcaa gacaaaccat caggaaccag     9960

gtgattaagg atgcaaccat atatttgtat catgaagagg atcggctcag aagtttctta    10020

tggtcaataa atcctctgtt ccctagattt ttaagtgaat tcaaatcagg cacttttttg    10080

ggagtcgcag acgggctcat cagtctattt caaaattctc gtactattcg gaactccttt    10140

aagaaaaagt atcataggga attggatgat ttgattgtga ggagtgaggt atcctctttg    10200

acacatttag ggaaacttca tttgagaagg ggatcatgta aaatgtggac atgttcagct    10260

actcatgctg acacattaag atacaaatcc tggggccgta cagttattgg gacaactgta    10320

ccccatccat tagaaatgtt gggtccacaa catcgaaaag agactccttg tgcaccatgt    10380

aacacatcag ggttcaatta tgtttctgtg cattgtccag acgggatcca tgacgtcttt    10440

agttcacggg gaccattgcc tgcttatcta gggtctaaaa catctgaatc tacatctatt    10500

ttgcagcctt gggaaaggga aagcaaagtc ccactgatta aaagagctac acgtcttaga    10560

gatgctatct cttggtttgt tgaacccgac tctaaactag caatgactat actttctaac    10620

atccactctt taacaggcga agaatggacc aaaaggcagc atgggttcaa aagaacaggg    10680

tctgcccttc ataggttttc gacatctcgg atgagccatg gtgggttcgc atctcagagc    10740

actgcagcat tgaccaggtt gatggcaact acagacacca tgagggatct gggagatcag    10800

aatttcgact ttttattcca agcaacgttg ctctatgctc aaattaccac cactgttgca    10860

agagacggat ggatcaccag ttgtacagat cattatcata ttgcctgtaa gtcctgtttg    10920

agacccatag aagagatcac cctggactca agtatggact acacgccccc agatgtatcc    10980

catgtgctga agacatggag gaatggggaa ggttcgtggg gacaagagat aaaacagatc    11040

tatcctttag aagggaattg gaagaattta gcacctgctg agcaatccta tcaagtcggc    11100

agatgtatag gttttctata tggagacttg gcgtatagaa aatctactca tgccgaggac    11160

agttctctat ttcctctatc tatacaaggt cgtattagag gtcgaggttt cttaaaaggg    11220

ttgctagacg gattaatgag agcaagttgc tgccaagtaa tacaccggag aagtctggct    11280

catttgaaga ggccggccaa cgcagtgtac ggaggtttga tttacttgat tgataaattg    11340

agtgtatcac ctccattcct ttctcttact agatcaggac ctattagaga cgaattagaa    11400

acgattcccc acaagatccc aacctcctat ccgacaagca accgtgatat gggggtgatt    11460

gtcagaaatt acttcaaata ccaatgccgt ctaattgaaa agggaaaata cagatcacat    11520

tattcacaat tatggttatt ctcagatgtc ttatccatag acttcattgg accattctct    11580

atttccacca ccctcttgca aatcctatac aagccatttt tatctgggaa agataagaat    11640

gagttgagag agctggcaaa tctttcttca ttgctaagat caggagaggg gtgggaagac    11700

atacatgtga aattcttcac caaggacata ttattgtgtc cagaggaaat cagacatgct    11760

tgcaagttcg ggattgctaa ggataataat aaagacatga gctatccccc ttggggaagg    11820

gaatccagag ggacaattac aacaatccct gtttattata cgaccacccc ttacccaaag    11880

atgctagaga tgcctccaag aatccaaaat cccctgctgt ccggaatcag gttgggccaa    11940

ttaccaactg gcgctcatta taaaattcgg agtatattac atggaatggg aatccattac    12000

agggacttct tgagttgtgg agacggctcc ggagggatga ctgctgcatt actacgagaa    12060

aatgtgcata gcagaggaat attcaatagt ctgttagaat tatcagggtc agtcatgcga    12120

ggcgcctctc ctgagccccc cagtgcccta gaaactttag gaggagataa atcgagatgt    12180

gtaaatggtg aaacatgttg ggaatatcca tctgacttat gtgacccaag gacttgggac    12240

tatttcctcc gactcaaagc aggcttgggg cttcaaattg atttaattgt aatggatatg    12300

gaagttcggg attcttctac tagcctgaaa attgagacga atgttagaaa ttatgtgcac    12360

cggattttgg atgagcaagg agttttaatc tacaagactt atggaacata tatttgtgag    12420

agcgaaaaga atgcagtaac aatccttggt cccatgttca agacggtcga cttagttcaa    12480

acagaattta gtagttctca aacgtctgaa gtatatatgg tatgtaaagg tttgaagaaa    12540

ttaatcgatg aacccaatcc cgattggtct tccatcaatg aatcctggaa aaacctgtac    12600

gcattccagt catcagaaca ggaatttgcc agagcaaaga aggttagtac atactttacc    12660

ttgacaggta ttccctccca attcattcct gatccttttg taaacattga gactatgcta    12720

caaatattcg gagtacccac gggtgtgtct catgcggctg ccttaaaatc atctgataga    12780

cctgcagatt tattgaccat tagccttttt tatatggcga ttatatcgta ttataacatc    12840

aatcatatca gagtaggacc gatacctccg aaccccccat cagatggaat tgcacaaaat    12900

gtggggatcg ctataactgg tataagcttt tggctgagtt tgatggagaa agacattcca    12960

ctatatcaac agtgtttagc agttatccag caatcattcc cgattaggtg ggaggctgtt    13020

tcagtaaaag gaggatacaa gcagaagtgg agtactagag gtgatgggct cccaaaagat    13080

acccgaattt cagactcctt ggccccaatc gggaactgga tcagatctct ggaattggtc    13140

cgaaaccaag ttcgtctaaa tccattcaat gagatcttgt tcaatcagct atgtcgtaca    13200

gtggataatc atttgaaatg gtcaaatttg cgaagaaaca caggaatgat tgaatggatc    13260

aatagacgaa tttcaaaaga agaccggtct atactgatgt tgaagagtga cctacacgag    13320

gaaaactctt ggagagatta aaaaatcatg aggagactcc aaactttaag tatgaaaaaa    13380

actttgatcc ttaagaccct cttgtggttt ttatttttta tctggttttg tggtcttcgt    13440


<210>  151
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for VSV-M protein in 
       rVSV-delta-G-SARS-CoV-2 clone MB1

<400>  151

Met Ser Ser Leu Lys Lys Ile Leu Gly Leu Lys Gly Lys Gly Lys Lys 
1               5                   10                  15      


Ser Lys Lys Leu Gly Ile Ala Pro Pro Pro Tyr Glu Glu Asp Thr Ser 
            20                  25                  30          


Met Glu Tyr Ala Pro Ser Ala Pro Ile Asp Lys Ser Tyr Phe Gly Val 
        35                  40                  45              


Asp Glu Met Asp Thr Tyr Asp Pro Asn Gln Leu Arg Ser Glu Lys Phe 
    50                  55                  60                  


Phe Phe Thr Val Lys Met Thr Val Arg Ser Asn Arg Pro Phe Arg Thr 
65                  70                  75                  80  


Tyr Ser Asp Val Ala Ala Ala Val Ser His Trp Asp His Met Tyr Ile 
                85                  90                  95      


Gly Met Ala Gly Lys Arg Pro Phe Tyr Lys Ile Leu Ala Phe Leu Gly 
            100                 105                 110         


Ser Ser Asn Leu Lys Ala Thr Pro Ala Val Leu Ala Asp Gln Gly Gln 
        115                 120                 125             


Pro Glu Tyr His Ala His Cys Glu Gly Arg Ala Tyr Leu Pro His Arg 
    130                 135                 140                 


Met Gly Lys Thr Pro Pro Met Leu Asn Val Pro Glu His Phe Arg Arg 
145                 150                 155                 160 


Pro Phe Asn Ile Gly Leu Tyr Lys Gly Thr Ile Glu Leu Thr Met Thr 
                165                 170                 175     


Ile Tyr Asp Asp Glu Ser Leu Glu Ala Ala Pro Met Ile Trp Asp His 
            180                 185                 190         


Phe Asn Ser Ser Lys Phe Ser Asp Phe Arg Glu Lys Ala Leu Met Phe 
        195                 200                 205             


Gly Leu Ile Val Glu Lys Lys Ala Ser Gly Ala Trp Val Leu Asp Ser 
    210                 215                 220                 


Ile Gly His Phe Lys 
225                 


<210>  152
<211>  2109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for VSV-L protein in 
       rVSV-delta-G-SARS-CoV-2 clone MB1, MB2, and Vectors A and B

<400>  152

Met Glu Val His Asp Phe Glu Thr Asp Glu Phe Asn Asp Phe Asn Glu 
1               5                   10                  15      


Asp Asp Tyr Ala Thr Arg Glu Phe Leu Asn Pro Asp Glu Arg Met Thr 
            20                  25                  30          


Tyr Leu Asn His Ala Asp Tyr Asn Leu Asn Ser Pro Leu Ile Ser Asp 
        35                  40                  45              


Asp Ile Asp Asn Leu Ile Arg Lys Phe Asn Ser Leu Pro Ile Pro Ser 
    50                  55                  60                  


Met Trp Asp Ser Lys Asn Trp Asp Gly Val Leu Glu Met Leu Thr Ser 
65                  70                  75                  80  


Cys Gln Ala Asn Pro Ile Pro Thr Ser Gln Met His Lys Trp Met Gly 
                85                  90                  95      


Ser Trp Leu Met Ser Asp Asn His Asp Ala Ser Gln Gly Tyr Ser Phe 
            100                 105                 110         


Leu His Glu Val Asp Lys Glu Ala Glu Ile Thr Phe Asp Val Val Glu 
        115                 120                 125             


Thr Phe Ile Arg Gly Trp Gly Asn Lys Pro Ile Glu Tyr Ile Lys Lys 
    130                 135                 140                 


Glu Arg Trp Thr Asp Ser Phe Lys Ile Leu Ala Tyr Leu Cys Gln Lys 
145                 150                 155                 160 


Phe Leu Asp Leu His Lys Leu Thr Leu Ile Leu Asn Ala Val Ser Glu 
                165                 170                 175     


Val Glu Leu Leu Asn Leu Ala Arg Thr Phe Lys Gly Lys Val Arg Arg 
            180                 185                 190         


Ser Ser His Gly Thr Asn Ile Cys Arg Ile Arg Val Pro Ser Leu Gly 
        195                 200                 205             


Pro Thr Phe Ile Ser Glu Gly Trp Ala Tyr Phe Lys Lys Leu Asp Ile 
    210                 215                 220                 


Leu Met Asp Arg Asn Phe Leu Leu Met Val Lys Asp Val Ile Ile Gly 
225                 230                 235                 240 


Arg Met Gln Thr Val Leu Ser Met Val Cys Arg Ile Asp Asn Leu Phe 
                245                 250                 255     


Ser Glu Gln Asp Ile Phe Ser Leu Leu Asn Ile Tyr Arg Ile Gly Asp 
            260                 265                 270         


Lys Ile Val Glu Arg Gln Gly Asn Phe Ser Tyr Asp Leu Ile Lys Met 
        275                 280                 285             


Val Glu Pro Ile Cys Asn Leu Lys Leu Met Lys Leu Ala Arg Glu Ser 
    290                 295                 300                 


Arg Pro Leu Val Pro Gln Phe Pro His Phe Glu Asn His Ile Lys Thr 
305                 310                 315                 320 


Ser Val Asp Glu Gly Ala Lys Ile Asp Arg Gly Ile Arg Phe Leu His 
                325                 330                 335     


Asp Gln Ile Met Ser Val Lys Thr Val Asp Leu Thr Leu Val Ile Tyr 
            340                 345                 350         


Gly Ser Phe Arg His Trp Gly His Pro Phe Ile Asp Tyr Tyr Thr Gly 
        355                 360                 365             


Leu Glu Lys Leu His Ser Gln Val Thr Met Lys Lys Asp Ile Asp Val 
    370                 375                 380                 


Ser Tyr Ala Lys Ala Leu Ala Ser Asp Leu Ala Arg Ile Val Leu Phe 
385                 390                 395                 400 


Gln Gln Phe Asn Asp His Lys Lys Trp Phe Val Asn Gly Asp Leu Leu 
                405                 410                 415     


Pro His Asp His Pro Phe Lys Ser His Val Lys Glu Asn Thr Trp Pro 
            420                 425                 430         


Thr Ala Ala Gln Val Gln Asp Phe Gly Asp Lys Trp His Glu Leu Pro 
        435                 440                 445             


Leu Ile Lys Cys Phe Glu Ile Pro Asp Leu Leu Asp Pro Ser Ile Ile 
    450                 455                 460                 


Tyr Ser Asp Lys Ser His Ser Met Asn Arg Ser Glu Val Leu Lys His 
465                 470                 475                 480 


Val Arg Met Asn Pro Asn Thr Pro Ile Pro Ser Lys Lys Val Leu Gln 
                485                 490                 495     


Thr Met Leu Asp Thr Lys Ala Thr Asn Trp Lys Glu Phe Leu Lys Glu 
            500                 505                 510         


Ile Asp Glu Lys Gly Leu Asp Asp Asp Asp Leu Ile Ile Gly Leu Lys 
        515                 520                 525             


Gly Lys Glu Arg Glu Leu Lys Leu Ala Gly Arg Phe Phe Ser Leu Met 
    530                 535                 540                 


Ser Trp Lys Leu Arg Glu Tyr Phe Val Ile Thr Glu Tyr Leu Ile Lys 
545                 550                 555                 560 


Thr His Phe Val Pro Met Phe Lys Gly Leu Thr Met Ala Asp Asp Leu 
                565                 570                 575     


Thr Ala Val Ile Lys Lys Met Leu Asp Ser Ser Ser Gly Gln Gly Leu 
            580                 585                 590         


Lys Ser Tyr Glu Ala Ile Cys Ile Ala Asn His Ile Asp Tyr Glu Lys 
        595                 600                 605             


Trp Asn Asn His Gln Arg Lys Leu Ser Asn Gly Pro Val Phe Arg Val 
    610                 615                 620                 


Met Gly Gln Phe Leu Gly Tyr Pro Ser Leu Ile Glu Arg Thr His Glu 
625                 630                 635                 640 


Phe Phe Glu Lys Ser Leu Ile Tyr Tyr Asn Gly Arg Pro Asp Leu Met 
                645                 650                 655     


Arg Val His Asn Asn Thr Leu Ile Asn Ser Thr Ser Gln Arg Val Cys 
            660                 665                 670         


Trp Gln Gly Gln Glu Gly Gly Leu Glu Gly Leu Arg Gln Lys Gly Trp 
        675                 680                 685             


Ser Ile Leu Asn Leu Leu Val Ile Gln Arg Glu Ala Lys Ile Arg Asn 
    690                 695                 700                 


Thr Ala Val Lys Val Leu Ala Gln Gly Asp Asn Gln Val Ile Cys Thr 
705                 710                 715                 720 


Gln Tyr Lys Thr Lys Lys Ser Arg Asn Val Val Glu Leu Gln Gly Ala 
                725                 730                 735     


Leu Asn Gln Met Val Ser Asn Asn Glu Lys Ile Met Thr Ala Ile Lys 
            740                 745                 750         


Ile Gly Thr Gly Lys Leu Gly Leu Leu Ile Asn Asp Asp Glu Thr Met 
        755                 760                 765             


Gln Ser Ala Asp Tyr Leu Asn Tyr Gly Lys Ile Pro Ile Phe Arg Gly 
    770                 775                 780                 


Val Ile Arg Gly Leu Glu Thr Lys Arg Trp Ser Arg Val Thr Cys Val 
785                 790                 795                 800 


Thr Asn Asp Gln Ile Pro Thr Cys Ala Asn Ile Met Ser Ser Val Ser 
                805                 810                 815     


Thr Asn Ala Leu Thr Val Ala His Phe Ala Glu Asn Pro Ile Asn Ala 
            820                 825                 830         


Met Ile Gln Tyr Asn Tyr Phe Gly Thr Phe Ala Arg Leu Leu Leu Met 
        835                 840                 845             


Met His Asp Pro Ala Leu Arg Gln Ser Leu Tyr Glu Val Gln Asp Lys 
    850                 855                 860                 


Ile Pro Gly Leu His Ser Ser Thr Phe Lys Tyr Ala Met Leu Tyr Leu 
865                 870                 875                 880 


Asp Pro Ser Ile Gly Gly Val Ser Gly Met Ser Leu Ser Arg Phe Leu 
                885                 890                 895     


Ile Arg Ala Phe Pro Asp Pro Val Thr Glu Ser Leu Ser Phe Trp Arg 
            900                 905                 910         


Phe Ile His Val His Ala Arg Ser Glu His Leu Lys Glu Met Ser Ala 
        915                 920                 925             


Val Phe Gly Asn Pro Glu Ile Ala Lys Phe Arg Ile Thr His Ile Asp 
    930                 935                 940                 


Lys Leu Val Glu Asp Pro Thr Ser Leu Asn Ile Ala Met Gly Met Ser 
945                 950                 955                 960 


Pro Ala Asn Leu Leu Lys Thr Glu Val Lys Lys Cys Leu Ile Glu Ser 
                965                 970                 975     


Arg Gln Thr Ile Arg Asn Gln Val Ile Lys Asp Ala Thr Ile Tyr Leu 
            980                 985                 990         


Tyr His Glu Glu Asp Arg Leu Arg  Ser Phe Leu Trp Ser  Ile Asn Pro 
        995                 1000                 1005             


Leu Phe  Pro Arg Phe Leu Ser  Glu Phe Lys Ser Gly  Thr Phe Leu 
    1010                 1015                 1020             


Gly Val  Ala Asp Gly Leu Ile  Ser Leu Phe Gln Asn  Ser Arg Thr 
    1025                 1030                 1035             


Ile Arg  Asn Ser Phe Lys Lys  Lys Tyr His Arg Glu  Leu Asp Asp 
    1040                 1045                 1050             


Leu Ile  Val Arg Ser Glu Val  Ser Ser Leu Thr His  Leu Gly Lys 
    1055                 1060                 1065             


Leu His  Leu Arg Arg Gly Ser  Cys Lys Met Trp Thr  Cys Ser Ala 
    1070                 1075                 1080             


Thr His  Ala Asp Thr Leu Arg  Tyr Lys Ser Trp Gly  Arg Thr Val 
    1085                 1090                 1095             


Ile Gly  Thr Thr Val Pro His  Pro Leu Glu Met Leu  Gly Pro Gln 
    1100                 1105                 1110             


His Arg  Lys Glu Thr Pro Cys  Ala Pro Cys Asn Thr  Ser Gly Phe 
    1115                 1120                 1125             


Asn Tyr  Val Ser Val His Cys  Pro Asp Gly Ile His  Asp Val Phe 
    1130                 1135                 1140             


Ser Ser  Arg Gly Pro Leu Pro  Ala Tyr Leu Gly Ser  Lys Thr Ser 
    1145                 1150                 1155             


Glu Ser  Thr Ser Ile Leu Gln  Pro Trp Glu Arg Glu  Ser Lys Val 
    1160                 1165                 1170             


Pro Leu  Ile Lys Arg Ala Thr  Arg Leu Arg Asp Ala  Ile Ser Trp 
    1175                 1180                 1185             


Phe Val  Glu Pro Asp Ser Lys  Leu Ala Met Thr Ile  Leu Ser Asn 
    1190                 1195                 1200             


Ile His  Ser Leu Thr Gly Glu  Glu Trp Thr Lys Arg  Gln His Gly 
    1205                 1210                 1215             


Phe Lys  Arg Thr Gly Ser Ala  Leu His Arg Phe Ser  Thr Ser Arg 
    1220                 1225                 1230             


Met Ser  His Gly Gly Phe Ala  Ser Gln Ser Thr Ala  Ala Leu Thr 
    1235                 1240                 1245             


Arg Leu  Met Ala Thr Thr Asp  Thr Met Arg Asp Leu  Gly Asp Gln 
    1250                 1255                 1260             


Asn Phe  Asp Phe Leu Phe Gln  Ala Thr Leu Leu Tyr  Ala Gln Ile 
    1265                 1270                 1275             


Thr Thr  Thr Val Ala Arg Asp  Gly Trp Ile Thr Ser  Cys Thr Asp 
    1280                 1285                 1290             


His Tyr  His Ile Ala Cys Lys  Ser Cys Leu Arg Pro  Ile Glu Glu 
    1295                 1300                 1305             


Ile Thr  Leu Asp Ser Ser Met  Asp Tyr Thr Pro Pro  Asp Val Ser 
    1310                 1315                 1320             


His Val  Leu Lys Thr Trp Arg  Asn Gly Glu Gly Ser  Trp Gly Gln 
    1325                 1330                 1335             


Glu Ile  Lys Gln Ile Tyr Pro  Leu Glu Gly Asn Trp  Lys Asn Leu 
    1340                 1345                 1350             


Ala Pro  Ala Glu Gln Ser Tyr  Gln Val Gly Arg Cys  Ile Gly Phe 
    1355                 1360                 1365             


Leu Tyr  Gly Asp Leu Ala Tyr  Arg Lys Ser Thr His  Ala Glu Asp 
    1370                 1375                 1380             


Ser Ser  Leu Phe Pro Leu Ser  Ile Gln Gly Arg Ile  Arg Gly Arg 
    1385                 1390                 1395             


Gly Phe  Leu Lys Gly Leu Leu  Asp Gly Leu Met Arg  Ala Ser Cys 
    1400                 1405                 1410             


Cys Gln  Val Ile His Arg Arg  Ser Leu Ala His Leu  Lys Arg Pro 
    1415                 1420                 1425             


Ala Asn  Ala Val Tyr Gly Gly  Leu Ile Tyr Leu Ile  Asp Lys Leu 
    1430                 1435                 1440             


Ser Val  Ser Pro Pro Phe Leu  Ser Leu Thr Arg Ser  Gly Pro Ile 
    1445                 1450                 1455             


Arg Asp  Glu Leu Glu Thr Ile  Pro His Lys Ile Pro  Thr Ser Tyr 
    1460                 1465                 1470             


Pro Thr  Ser Asn Arg Asp Met  Gly Val Ile Val Arg  Asn Tyr Phe 
    1475                 1480                 1485             


Lys Tyr  Gln Cys Arg Leu Ile  Glu Lys Gly Lys Tyr  Arg Ser His 
    1490                 1495                 1500             


Tyr Ser  Gln Leu Trp Leu Phe  Ser Asp Val Leu Ser  Ile Asp Phe 
    1505                 1510                 1515             


Ile Gly  Pro Phe Ser Ile Ser  Thr Thr Leu Leu Gln  Ile Leu Tyr 
    1520                 1525                 1530             


Lys Pro  Phe Leu Ser Gly Lys  Asp Lys Asn Glu Leu  Arg Glu Leu 
    1535                 1540                 1545             


Ala Asn  Leu Ser Ser Leu Leu  Arg Ser Gly Glu Gly  Trp Glu Asp 
    1550                 1555                 1560             


Ile His  Val Lys Phe Phe Thr  Lys Asp Ile Leu Leu  Cys Pro Glu 
    1565                 1570                 1575             


Glu Ile  Arg His Ala Cys Lys  Phe Gly Ile Ala Lys  Asp Asn Asn 
    1580                 1585                 1590             


Lys Asp  Met Ser Tyr Pro Pro  Trp Gly Arg Glu Ser  Arg Gly Thr 
    1595                 1600                 1605             


Ile Thr  Thr Ile Pro Val Tyr  Tyr Thr Thr Thr Pro  Tyr Pro Lys 
    1610                 1615                 1620             


Met Leu  Glu Met Pro Pro Arg  Ile Gln Asn Pro Leu  Leu Ser Gly 
    1625                 1630                 1635             


Ile Arg  Leu Gly Gln Leu Pro  Thr Gly Ala His Tyr  Lys Ile Arg 
    1640                 1645                 1650             


Ser Ile  Leu His Gly Met Gly  Ile His Tyr Arg Asp  Phe Leu Ser 
    1655                 1660                 1665             


Cys Gly  Asp Gly Ser Gly Gly  Met Thr Ala Ala Leu  Leu Arg Glu 
    1670                 1675                 1680             


Asn Val  His Ser Arg Gly Ile  Phe Asn Ser Leu Leu  Glu Leu Ser 
    1685                 1690                 1695             


Gly Ser  Val Met Arg Gly Ala  Ser Pro Glu Pro Pro  Ser Ala Leu 
    1700                 1705                 1710             


Glu Thr  Leu Gly Gly Asp Lys  Ser Arg Cys Val Asn  Gly Glu Thr 
    1715                 1720                 1725             


Cys Trp  Glu Tyr Pro Ser Asp  Leu Cys Asp Pro Arg  Thr Trp Asp 
    1730                 1735                 1740             


Tyr Phe  Leu Arg Leu Lys Ala  Gly Leu Gly Leu Gln  Ile Asp Leu 
    1745                 1750                 1755             


Ile Val  Met Asp Met Glu Val  Arg Asp Ser Ser Thr  Ser Leu Lys 
    1760                 1765                 1770             


Ile Glu  Thr Asn Val Arg Asn  Tyr Val His Arg Ile  Leu Asp Glu 
    1775                 1780                 1785             


Gln Gly  Val Leu Ile Tyr Lys  Thr Tyr Gly Thr Tyr  Ile Cys Glu 
    1790                 1795                 1800             


Ser Glu  Lys Asn Ala Val Thr  Ile Leu Gly Pro Met  Phe Lys Thr 
    1805                 1810                 1815             


Val Asp  Leu Val Gln Thr Glu  Phe Ser Ser Ser Gln  Thr Ser Glu 
    1820                 1825                 1830             


Val Tyr  Met Val Cys Lys Gly  Leu Lys Lys Leu Ile  Asp Glu Pro 
    1835                 1840                 1845             


Asn Pro  Asp Trp Ser Ser Ile  Asn Glu Ser Trp Lys  Asn Leu Tyr 
    1850                 1855                 1860             


Ala Phe  Gln Ser Ser Glu Gln  Glu Phe Ala Arg Ala  Lys Lys Val 
    1865                 1870                 1875             


Ser Thr  Tyr Phe Thr Leu Thr  Gly Ile Pro Ser Gln  Phe Ile Pro 
    1880                 1885                 1890             


Asp Pro  Phe Val Asn Ile Glu  Thr Met Leu Gln Ile  Phe Gly Val 
    1895                 1900                 1905             


Pro Thr  Gly Val Ser His Ala  Ala Ala Leu Lys Ser  Ser Asp Arg 
    1910                 1915                 1920             


Pro Ala  Asp Leu Leu Thr Ile  Ser Leu Phe Tyr Met  Ala Ile Ile 
    1925                 1930                 1935             


Ser Tyr  Tyr Asn Ile Asn His  Ile Arg Val Gly Pro  Ile Pro Pro 
    1940                 1945                 1950             


Asn Pro  Pro Ser Asp Gly Ile  Ala Gln Asn Val Gly  Ile Ala Ile 
    1955                 1960                 1965             


Thr Gly  Ile Ser Phe Trp Leu  Ser Leu Met Glu Lys  Asp Ile Pro 
    1970                 1975                 1980             


Leu Tyr  Gln Gln Cys Leu Ala  Val Ile Gln Gln Ser  Phe Pro Ile 
    1985                 1990                 1995             


Arg Trp  Glu Ala Val Ser Val  Lys Gly Gly Tyr Lys  Gln Lys Trp 
    2000                 2005                 2010             


Ser Thr  Arg Gly Asp Gly Leu  Pro Lys Asp Thr Arg  Ile Ser Asp 
    2015                 2020                 2025             


Ser Leu  Ala Pro Ile Gly Asn  Trp Ile Arg Ser Leu  Glu Leu Val 
    2030                 2035                 2040             


Arg Asn  Gln Val Arg Leu Asn  Pro Phe Asn Glu Ile  Leu Phe Asn 
    2045                 2050                 2055             


Gln Leu  Cys Arg Thr Val Asp  Asn His Leu Lys Trp  Ser Asn Leu 
    2060                 2065                 2070             


Arg Arg  Asn Thr Gly Met Ile  Glu Trp Ile Asn Arg  Arg Ile Ser 
    2075                 2080                 2085             


Lys Glu  Asp Arg Ser Ile Leu  Met Leu Lys Ser Asp  Leu His Glu 
    2090                 2095                 2100             


Glu Asn  Ser Trp Arg Asp 
    2105                 


<210>  153
<211>  1250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for SARS-CoV-2 S protein in 
       rVSV-delta-G-SARS-CoV-2 clone MB1

<400>  153

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Gly Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Phe Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  
    1250 


<210>  154
<211>  13440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence for rVSV-delta-G-SARS-CoV-2 clone 
       MB2

<400>  154
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttacg cgctagtgga tcctactcga gaggagccac catgttcgtg ttcctggtgc     3120

tattacctct ggtttcgtct caatgcgtaa accttacaac tagaactcag cttcctccag     3180

catacacaaa ttccttcact cgcggagtgt attatcctga taaggtcttt cgatcatcag     3240

tgttgcattc cacccaggat ttgtttctcc cgttcttttc aaatgtaact tggttccatg     3300

ctatacatgt ttccggaacc aatggaacaa agagatttga taacccagtg ttaccattta     3360

acgacggagt ttatttcgca tcaactgaga aatccaatat cattagaggc tggattttcg     3420

gaacgaccct ggattctaaa acgcaatcct tgctgattgt taataatgca acaaatgtgg     3480

tcattaaagt ctgtgaattc caattttgca atgatccatt tctcggcgtc tattaccaca     3540

agaataacaa atcttggatg gagtcagagt tcagggttta tagttccgca aataattgta     3600

cttttgaata cgtttcccaa ccattcttaa tggacttgga gggaaaacag ggaaatttta     3660

agaatctaag agaattcgtc tttaagaata ttgatggata tttcaagatc tattcaaaac     3720

atacacctat aaacctagtt agagatctcc cgcaagggtt ttcagcccta gagccactag     3780

ttgacctgcc aattgggatc aacattacta gattccagac cctactcgct ctgcatcggt     3840

catatttgac accaggagat tcatcgtcag gatggaccgc tggagcagct gcttactatg     3900

ttgggtatct gcaacctaga acatttctcc taaagtataa tgaaaacggg actattacag     3960

acgcagtcga ttgcgcactg gatccactct cagagacaaa gtgcactcta aaatcattca     4020

ctgtcgagaa aggaatctat caaacatcaa atttcagggt ccagccaact gagagtattg     4080

tccggttccc taacataact aacttgtgcc ccttcggaga ggttttcaat gctactcggt     4140

tcgccagcgt ctacgcatgg aacagaaaga ggatttcaaa ctgtgtcgca gattatagcg     4200

tcctctataa ttcagcatca ttcagtacat ttaaatgcta tggtgtcagc cccaccaaac     4260

ttaatgactt atgttttacc aatgtatatg cagattcctt tgtaatcaga ggtgacgaag     4320

tgaggcaaat cgcacctgga cagaccggaa agattgctga ttataattat aaactccctg     4380

atgattttac cggatgtgtt attgcttgga acagcaataa cctcgatagt aaggtcggag     4440

gaaactataa ctatttgtac agactgttta gaaagtcgaa tttgaaacct tttgaaagag     4500

acatatccac cgagatttac caggcgggca gcacaccgtg taatggtgta gaaggattca     4560

attgttactt tcccctgcaa tcatatgggt ttcaaccaac caatggagtc ggatatcaac     4620

catatcgtgt cgtcgtcctt tccttcgagc tgcttcatgc accagctaca gtctgcggac     4680

ctaagaagag cactaatctt gtcaagaaca aatgtgtgaa ctttaatttt aatggattaa     4740

caggaaccgg agttttgacc gagagtaata agaagttctt gccgttccag caatttggac     4800

gagacattgc tgacaccaca gatgcggttc gtgacccgca aactttagag atcctagaca     4860

tcaccccatg ttcattcggt ggagtttccg ttattactcc tggaacgaat acaagcaatc     4920

aagttgccgt tctctatcaa gatgttaatt gtacagaagt gcctgtggcc attcatgcag     4980

atcaactaac accaacttgg agagtttaca gcactgggtc caatgtcttc caaacgcgcg     5040

ccggctgcct cattggtgca gaatatgtga ataactcata cgaatgtgac attccaatcg     5100

gtgccggcat atgcgcctct taccagactc agactaattc gccaagaaga gccaggtctg     5160

tcgcaagtca gtcaattatt gcatacacaa tgtcgttagg agcagagaat agtgtagcat     5220

actcaaacaa ttctatagca atacctacca acttcactat atcagtaact acagaaatat     5280

tgccagtatc catgactaaa acaagtgtgg attgcaccat gtacatctgt ggagattcca     5340

cagaatgcag caatcttctc ttgcaatacg gatcattctg cacacaactg aatagggcac     5400

tgactggaat tgcagtcgag caggataaga acacacagga ggtgtttgcc caagtcaaac     5460

aaatatacaa aacaccaccc atcaaggatt ttggaggatt taatttctca caaatactcc     5520

ccgacccatc caagccctcc aaaaggagtt tcattgagga cctcttgttt aataaggtta     5580

ccttggcaga tgccgggttt attaagcagt acggcgactg tcttggagac atagcagcca     5640

gagatctaat ttgtgcccag aaattcaatg gactgacagt cctgcctccc ttattaactg     5700

atgagatgat agctcagtat acatcagcat tgttggctgg tacaattaca tctggatgga     5760

catttggtgc cggagcggca ttacaaatcc cttttgcaat gcaaatggcc tatagattta     5820

atggaatcgg agtaactcaa aatgttttat atgagaatca gaaattaatt gcaaatcaat     5880

tcaattcagc tataggaaag attcaggatt cactcagtag tacagcaagc gctctaggca     5940

aattacaaga cgtcgtcaat cagaatgcac aggcattaaa tacactggtg aagcaattga     6000

gttccaattt cggagcaatt tcatctgttc taaatgatat attgtcaaga ctggataaag     6060

tagaagccga ggtccaaatc gataggctga tcacaggaag acttcaatca ctacagacat     6120

acgtcaccca acaactcatc agagcagcag aaattagagc ctctgctaat ctagccgcaa     6180

caaagatgtc agagtgcgta ttgggacaat ctaagagggt cgacttttgt ggaaaggggt     6240

atcacttgat gtcctttcct caatctgcac cacacggagt tgtcttctta catgtaacat     6300

atgtgcccgc tcaagaaaag aatttcacta cagcacctgc aatatgtcat gacggaaaag     6360

cacattttcc tcgggaggga gttttcgttt ctaatggaac ccattggttc gtgacccaaa     6420

ggaactttta cgagcctcaa ataattacaa ctgataatac attcgtttct ggaaattgcg     6480

acgtagttat aggtattgta aataatactg tttatgaccc tttacaacct gaactcgatt     6540

ccttcaagga agaactcgac aaatatttta agaatcacac ctcaccggac gttgacttag     6600

gagacatttc cgggattaac gctagtgtag tcaatatcca aaaggagata gatagactga     6660

atgaggtagc aaagaatctt aatgaatctt tgatcgacct tcaggagctg gggaagtacg     6720

aacaatacat aaaatggcca tggtacattt ggctcgggtt tattgctgga ctaattgcaa     6780

tagtcatggt cactatcatg ctgtgttgta tgacatcgtg ctgctcatgc ctcaagggat     6840

gttgtagctg ttgatcttgt tgcaagttcg atgaggatga ttcagaacca gttttaaaag     6900

gagtaaagtt gcattacaca taaaggctag ctgtttacgc gttatccatg ctcaaagagg     6960

cctcaattat atttgagttt ttaattttta tgaaaaaaac taacagcaat catggaagtc     7020

cacgattttg agaccgacga gttcaatgat ttcaatgaag atgactatgc cacaagagaa     7080

ttcctgaatc ccgatgagcg catgacgtac ttgaatcatg ctgattacaa cctgaattct     7140

cctctaatta gtgatgatat tgacaattta atcaggaaat tcaattctct tccaattccc     7200

tcgatgtggg atagtaagaa ctgggatgga gttcttgaga tgttaacgtc atgtcaagcc     7260

aatcccatcc caacatctca gatgcataaa tggatgggaa gttggttaat gtctgataat     7320

catgatgcca gtcaagggta tagtttttta catgaagtgg acaaagaggc agaaataaca     7380

tttgacgtgg tggagacctt catccgcggc tggggcaaca aaccaattga atacatcaaa     7440

aaggaaagat ggactgactc attcaaaatt ctcgcttatt tgtgtcaaaa gtttttggac     7500

ttacacaagt tgacattaat cttaaatgct gtctctgagg tggaattgct caacttggcg     7560

aggactttca aaggcaaagt cagaagaagt tctcatggaa cgaacatatg caggattagg     7620

gttcccagct tgggtcctac ttttatttca gaaggatggg cttacttcaa gaaacttgat     7680

attctaatgg accgaaactt tctgttaatg gtcaaagatg tgattatagg gaggatgcaa     7740

acggtgctat ccatggtatg tagaatagac aacctgttct cagagcaaga catcttctcc     7800

cttctaaata tctacagaat tggagataaa attgtggaga ggcagggaaa tttttcttat     7860

gacttgatta aaatggtgga accgatatgc aacttgaagc tgatgaaatt agcaagagaa     7920

tcaaggcctt tagtcccaca attccctcat tttgaaaatc atatcaagac ttctgttgat     7980

gaaggggcaa aaattgaccg aggtataaga ttcctccatg atcagataat gagtgtgaaa     8040

acagtggatc tcacactggt gatttatgga tcgttcagac attggggtca tccttttata     8100

gattattaca ctggactaga aaaattacat tcccaagtaa ccatgaagaa agatattgat     8160

gtgtcatatg caaaagcact tgcaagtgat ttagctcgga ttgttctatt tcaacagttc     8220

aatgatcata aaaagtggtt cgtgaatgga gacttgctcc ctcatgatca tccctttaaa     8280

agtcatgtta aagaaaatac atggcccaca gctgctcaag ttcaagattt tggagataaa     8340

tggcatgaac ttccgctgat taaatgtttt gaaatacccg acttactaga cccatcgata     8400

atatactctg acaaaagtca ttcaatgaat aggtcagagg tgttgaaaca tgtccgaatg     8460

aatccgaaca ctcctatccc tagtaaaaag gtgttgcaga ctatgttgga cacaaaggct     8520

accaattgga aagaatttct taaagagatt gatgagaagg gcttagatga tgatgatcta     8580

attattggtc ttaaaggaaa ggagagggaa ctgaagttgg caggtagatt tttctcccta     8640

atgtcttgga aattgcgaga atactttgta attaccgaat atttgataaa gactcatttc     8700

gtccctatgt ttaaaggcct gacaatggcg gacgatctaa ctgcagtcat taaaaagatg     8760

ttagattcct catccggcca aggattgaag tcatatgagg caatttgcat agccaatcac     8820

attgattacg aaaaatggaa taaccaccaa aggaagttat caaacggccc agtgttccga     8880

gttatgggcc agttcttagg ttatccatcc ttaatcgaga gaactcatga attttttgag     8940

aaaagtctta tatactacaa tggaagacca gacttgatgc gtgttcacaa caacacactg     9000

atcaattcaa cctcccaacg agtttgttgg caaggacaag agggtggact ggaaggtcta     9060

cggcaaaaag gatggagtat cctcaatcta ctggttattc aaagagaggc taaaatcaga     9120

aacactgctg tcaaagtctt ggcacaaggt gataatcaag ttatttgcac acagtataaa     9180

acgaagaaat cgagaaacgt tgtagaatta cagggtgctc tcaatcaaat ggtttctaat     9240

aatgagaaaa ttatgactgc aatcaaaata gggacaggga agttaggact tttgataaat     9300

gacgatgaga ctatgcaatc tgcagattac ttgaattatg gaaaaatacc gattttccgt     9360

ggagtgatta gagggttaga gaccaagaga tggtcacgag tgacttgtgt caccaatgac     9420

caaataccca cttgtgctaa tataatgagc tcagtttcca caaatgctct caccgtagct     9480

cattttgctg agaacccaat caatgccatg atacagtaca attattttgg gacatttgct     9540

agactcttgt tgatgatgca tgatcctgct cttcgtcaat cattgtatga agttcaagat     9600

aagataccag gcttgcacag ttctactttc aaatacgcca tgttgtattt ggacccttcc     9660

attggaggag tgtcgggcat gtctttgtcc aggtttttga ttagagcctt cccagatccc     9720

gtaacagaaa gtctctcatt ctggagattc atccatgtac atgctcgaag tgagcatctg     9780

aaggagatga gtgcagtatt tggaaacccc gagatagcca agtttcgaat aactcacata     9840

gacaagctag tagaagatcc aacctctctg aacatcgcta tgggaatgag tccagcgaac     9900

ttgttaaaga ctgaggttaa aaaatgctta atcgaatcaa gacaaaccat caggaaccag     9960

gtgattaagg atgcaaccat atatttgtat catgaagagg atcggctcag aagtttctta    10020

tggtcaataa atcctctgtt ccctagattt ttaagtgaat tcaaatcagg cacttttttg    10080

ggagtcgcag acgggctcat cagtctattt caaaattctc gtactattcg gaactccttt    10140

aagaaaaagt atcataggga attggatgat ttgattgtga ggagtgaggt atcctctttg    10200

acacatttag ggaaacttca tttgagaagg ggatcatgta aaatgtggac atgttcagct    10260

actcatgctg acacattaag atacaaatcc tggggccgta cagttattgg gacaactgta    10320

ccccatccat tagaaatgtt gggtccacaa catcgaaaag agactccttg tgcaccatgt    10380

aacacatcag ggttcaatta tgtttctgtg cattgtccag acgggatcca tgacgtcttt    10440

agttcacggg gaccattgcc tgcttatcta gggtctaaaa catctgaatc tacatctatt    10500

ttgcagcctt gggaaaggga aagcaaagtc ccactgatta aaagagctac acgtcttaga    10560

gatgctatct cttggtttgt tgaacccgac tctaaactag caatgactat actttctaac    10620

atccactctt taacaggcga agaatggacc aaaaggcagc atgggttcaa aagaacaggg    10680

tctgcccttc ataggttttc gacatctcgg atgagccatg gtgggttcgc atctcagagc    10740

actgcagcat tgaccaggtt gatggcaact acagacacca tgagggatct gggagatcag    10800

aatttcgact ttttattcca agcaacgttg ctctatgctc aaattaccac cactgttgca    10860

agagacggat ggatcaccag ttgtacagat cattatcata ttgcctgtaa gtcctgtttg    10920

agacccatag aagagatcac cctggactca agtatggact acacgccccc agatgtatcc    10980

catgtgctga agacatggag gaatggggaa ggttcgtggg gacaagagat aaaacagata    11040

tatcctttag aagggaattg gaagaattta gcacctgctg agcaatccta tcaagtcggc    11100

agatgtatag gttttctata tggagacttg gcgtatagaa aatctactca tgccgaggac    11160

agttctctat ttcctctatc tatacaaggt cgtattagag gtcgaggttt cttaaaaggg    11220

ttgctagacg gattaatgag agcaagttgc tgccaagtaa tacaccggag aagtctggct    11280

catttgaaga ggccggccaa cgcagtgtac ggaggtttga tttacttgat tgataaattg    11340

agtgtatcac ctccattcct ttctcttact agatcaggac ctattagaga cgaattagaa    11400

acgattcccc acaagatccc aacctcctat ccgacaagca accgtgatat gggggtgatt    11460

gtcagaaatt acttcaaata ccaatgccgt ctaattgaaa agggaaaata cagatcacat    11520

tattcacaat tatggttatt ctcagatgtc ttatccatag acttcattgg accattctct    11580

atttccacca ccctcttgca aatcctatac aagccatttt tatctgggaa agataagaat    11640

gagttgagag agctggcaaa tctttcttca ttgctaagat caggagaggg gtgggaagac    11700

atacatgtga aattcttcac caaggacata ttattgtgtc cagaggaaat cagacatgct    11760

tgcaagttcg ggattgctaa ggataataat aaagacatga gctatccccc ttggggaagg    11820

gaatccagag ggacaattac aacaatccct gtttattata cgaccacccc ttacccaaag    11880

atgctagaga tgcctccaag aatccaaaat cccctgctgt ccggaatcag gttgggccaa    11940

ttaccaactg gcgctcatta taaaattcgg agtatattac atggaatggg aatccattac    12000

agggacttct tgagttgtgg agacggctcc ggagggatga ctgctgcatt actacgagaa    12060

aatgtgcata gcagaggaat attcaatagt ctgttagaat tatcagggtc agtcatgcga    12120

ggcgcctctc ctgagccccc cagtgcccta gaaactttag gaggagataa atcgagatgt    12180

gtaaatggtg aaacatgttg ggaatatcca tctgacttat gtgacccaag gacttgggac    12240

tatttcctcc gactcaaagc aggcttgggg cttcaaattg atttaattgt aatggatatg    12300

gaagttcggg attcttctac tagcctgaaa attgagacga atgttagaaa ttatgtgcac    12360

cggattttgg atgagcaagg agttttaatc tacaagactt atggaacata tatttgtgag    12420

agcgaaaaga atgcagtaac aatccttggt cccatgttca agacggtcga cttagttcaa    12480

acagaattta gtagttctca aacgtctgaa gtatatatgg tatgtaaagg tttgaagaaa    12540

ttaatcgatg aacccaatcc cgattggtct tccatcaatg aatcctggaa aaacctgtac    12600

gcattccagt catcagaaca ggaatttgcc agagcaaaga aggttagtac atactttacc    12660

ttgacaggta ttccctccca attcattcct gatccttttg taaacattga gactatgcta    12720

caaatattcg gagtacccac gggtgtgtct catgcggctg ccttaaaatc atctgataga    12780

cctgcagatt tattgaccat tagccttttt tatatggcga ttatatcgta ttataacatc    12840

aatcatatca gagtaggacc gatacctccg aaccccccat cagatggaat tgcacaaaat    12900

gtggggatcg ctataactgg tataagcttt tggctgagtt tgatggagaa agacattcca    12960

ctatatcaac agtgtttagc agttatccag caatcattcc cgattaggtg ggaggctgtt    13020

tcagtaaaag gaggatacaa gcagaagtgg agtactagag gtgatgggct cccaaaagat    13080

acccgaattt cagactcctt ggccccaatc gggaactgga tcagatctct ggaattggtc    13140

cgaaaccaag ttcgtctaaa tccattcaat gagatcttgt tcaatcagct atgtcgtaca    13200

gtggataatc atttgaaatg gtcaaatttg cgaagaaaca caggaatgat tgaatggatc    13260

aatagacgaa tttcaaaaga agaccggtct atactgatgt tgaagagtga cctacacgag    13320

gaaaactctt ggagagatta aaaaatcatg aggagactcc aaactttaag tatgaaaaaa    13380

actttgatcc ttaagaccct cttgtggttt ttatttttta tctggttttg tggtcttcgt    13440


<210>  155
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for VSV-N protein in 
       rVSV-delta-G-SARS-CoV-2 clones MB1 and MB2, and Vectors A and B

<400>  155

Met Ser Val Thr Val Lys Arg Ile Ile Asp Asn Thr Val Val Val Pro 
1               5                   10                  15      


Lys Leu Pro Ala Asn Glu Asp Pro Val Glu Tyr Pro Ala Asp Tyr Phe 
            20                  25                  30          


Arg Lys Ser Lys Glu Ile Pro Leu Tyr Ile Asn Thr Thr Lys Ser Leu 
        35                  40                  45              


Ser Asp Leu Arg Gly Tyr Val Tyr Gln Gly Leu Lys Ser Gly Asn Val 
    50                  55                  60                  


Ser Ile Ile His Val Asn Ser Tyr Leu Tyr Gly Ala Leu Lys Asp Ile 
65                  70                  75                  80  


Arg Gly Lys Leu Asp Lys Asp Trp Ser Ser Phe Gly Ile Asn Ile Gly 
                85                  90                  95      


Lys Ala Gly Asp Thr Ile Gly Ile Phe Asp Leu Val Ser Leu Lys Ala 
            100                 105                 110         


Leu Asp Gly Val Leu Pro Asp Gly Val Ser Asp Ala Ser Arg Thr Ser 
        115                 120                 125             


Ala Asp Asp Lys Trp Leu Pro Leu Tyr Leu Leu Gly Leu Tyr Arg Val 
    130                 135                 140                 


Gly Arg Thr Gln Met Pro Glu Tyr Arg Lys Lys Leu Met Asp Gly Leu 
145                 150                 155                 160 


Thr Asn Gln Cys Lys Met Ile Asn Glu Gln Phe Glu Pro Leu Val Pro 
                165                 170                 175     


Glu Gly Arg Asp Ile Phe Asp Val Trp Gly Asn Asp Ser Asn Tyr Thr 
            180                 185                 190         


Lys Ile Val Ala Ala Val Asp Met Phe Phe His Met Phe Lys Lys His 
        195                 200                 205             


Glu Cys Ala Ser Phe Arg Tyr Gly Thr Ile Val Ser Arg Phe Lys Asp 
    210                 215                 220                 


Cys Ala Ala Leu Ala Thr Phe Gly His Leu Cys Lys Ile Thr Gly Met 
225                 230                 235                 240 


Ser Thr Glu Asp Val Thr Thr Trp Ile Leu Asn Arg Glu Val Ala Asp 
                245                 250                 255     


Glu Met Val Gln Met Met Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp 
            260                 265                 270         


Ser Tyr Met Pro Tyr Leu Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro 
        275                 280                 285             


Tyr Ser Ser Val Lys Asn Pro Ala Phe His Phe Trp Gly Gln Leu Thr 
    290                 295                 300                 


Ala Leu Leu Leu Arg Ser Thr Arg Ala Arg Asn Ala Arg Gln Pro Asp 
305                 310                 315                 320 


Asp Ile Glu Tyr Thr Ser Leu Thr Thr Ala Gly Leu Leu Tyr Ala Tyr 
                325                 330                 335     


Ala Val Gly Ser Ser Ala Asp Leu Ala Gln Gln Phe Cys Val Gly Asp 
            340                 345                 350         


Asn Lys Tyr Thr Pro Asp Asp Ser Thr Gly Gly Leu Thr Thr Asn Ala 
        355                 360                 365             


Pro Pro Gln Gly Arg Asp Val Val Glu Trp Leu Gly Trp Phe Glu Asp 
    370                 375                 380                 


Gln Asn Arg Lys Pro Thr Pro Asp Met Met Gln Tyr Ala Lys Arg Ala 
385                 390                 395                 400 


Val Met Ser Leu Gln Gly Leu Arg Glu Lys Thr Ile Gly Lys Tyr Ala 
                405                 410                 415     


Lys Ser Glu Phe Asp Lys 
            420         


<210>  156
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for VSV-P protein in 
       rVSV-delta-G-SARS-CoV-2 clones MB1 and MB2, and Vectors A and B

<400>  156

Met Asp Asn Leu Thr Lys Val Arg Glu Tyr Leu Lys Ser Tyr Ser Arg 
1               5                   10                  15      


Leu Asp Gln Ala Val Gly Glu Ile Asp Glu Ile Glu Ala Gln Arg Ala 
            20                  25                  30          


Glu Lys Ser Asn Tyr Glu Leu Phe Gln Glu Asp Gly Val Glu Glu His 
        35                  40                  45              


Thr Lys Pro Ser Tyr Phe Gln Ala Ala Asp Asp Ser Asp Thr Glu Ser 
    50                  55                  60                  


Glu Pro Glu Ile Glu Asp Asn Gln Gly Leu Tyr Ala Pro Asp Pro Glu 
65                  70                  75                  80  


Ala Glu Gln Val Glu Gly Phe Ile Gln Gly Pro Leu Asp Asp Tyr Ala 
                85                  90                  95      


Asp Glu Glu Val Asp Val Val Phe Thr Ser Asp Trp Lys Gln Pro Glu 
            100                 105                 110         


Leu Glu Ser Asp Glu His Gly Lys Thr Leu Arg Leu Thr Ser Pro Glu 
        115                 120                 125             


Gly Leu Ser Gly Glu Gln Lys Ser Gln Trp Leu Ser Thr Ile Lys Ala 
    130                 135                 140                 


Val Val Gln Ser Ala Lys Tyr Trp Asn Leu Ala Glu Cys Thr Phe Glu 
145                 150                 155                 160 


Ala Ser Gly Glu Gly Val Ile Met Lys Glu Arg Gln Ile Thr Pro Asp 
                165                 170                 175     


Val Tyr Lys Val Thr Pro Val Met Asn Thr His Pro Ser Gln Ser Glu 
            180                 185                 190         


Ala Val Ser Asp Val Trp Ser Leu Ser Lys Thr Ser Met Thr Phe Gln 
        195                 200                 205             


Pro Lys Lys Ala Ser Leu Gln Pro Leu Thr Ile Ser Leu Asp Glu Leu 
    210                 215                 220                 


Phe Ser Ser Arg Gly Glu Phe Ile Ser Val Gly Gly Asp Gly Arg Met 
225                 230                 235                 240 


Ser His Lys Glu Ala Ile Leu Leu Gly Leu Arg Tyr Lys Lys Leu Tyr 
                245                 250                 255     


Asn Gln Ala Arg Val Lys Tyr Ser Leu 
            260                 265 


<210>  157
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for VSV-M protein in 
       rVSV-delta-G-SARS-CoV-2 clone MB2, and Vectors A and B

<400>  157

Met Ser Ser Leu Lys Lys Ile Leu Gly Leu Lys Gly Lys Gly Lys Lys 
1               5                   10                  15      


Ser Lys Lys Leu Gly Ile Ala Pro Pro Pro Tyr Glu Glu Asp Thr Ser 
            20                  25                  30          


Met Glu Tyr Ala Pro Ser Ala Pro Ile Asp Lys Ser Tyr Phe Gly Val 
        35                  40                  45              


Asp Glu Met Asp Thr Tyr Asp Pro Asn Gln Leu Arg Tyr Glu Lys Phe 
    50                  55                  60                  


Phe Phe Thr Val Lys Met Thr Val Arg Ser Asn Arg Pro Phe Arg Thr 
65                  70                  75                  80  


Tyr Ser Asp Val Ala Ala Ala Val Ser His Trp Asp His Met Tyr Ile 
                85                  90                  95      


Gly Met Ala Gly Lys Arg Pro Phe Tyr Lys Ile Leu Ala Phe Leu Gly 
            100                 105                 110         


Ser Ser Asn Leu Lys Ala Thr Pro Ala Val Leu Ala Asp Gln Gly Gln 
        115                 120                 125             


Pro Glu Tyr His Ala His Cys Glu Gly Arg Ala Tyr Leu Pro His Arg 
    130                 135                 140                 


Met Gly Lys Thr Pro Pro Met Leu Asn Val Pro Glu His Phe Arg Arg 
145                 150                 155                 160 


Pro Phe Asn Ile Gly Leu Tyr Lys Gly Thr Ile Glu Leu Thr Met Thr 
                165                 170                 175     


Ile Tyr Asp Asp Glu Ser Leu Glu Ala Ala Pro Met Ile Trp Asp His 
            180                 185                 190         


Phe Asn Ser Ser Lys Phe Ser Asp Phe Arg Glu Lys Ala Leu Met Phe 
        195                 200                 205             


Gly Leu Ile Val Glu Lys Lys Ala Ser Gly Ala Trp Val Leu Asp Ser 
    210                 215                 220                 


Ile Gly His Phe Lys 
225                 


<210>  158
<211>  1250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for SARS-CoV-2 S protein in 
       rVSV-delta-G-SARS-CoV-2 clone MB2

<400>  158

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  
    1250 


<210>  159
<211>  13441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence for rVSV-delta-G-SARS-CoV-2 with 
       codon-optimized, wild-type S protein

<400>  159
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttacg cgctagtgga tcctactcga gaggagccac catgttcgtg ttcctggtgc     3120

tattacctct ggtttcgtct caatgcgtaa accttacaac tagaactcag cttcctccag     3180

catacacaaa ttccttcact cgcggagtgt attatcctga taaggtcttt cgatcatcag     3240

tgttgcattc cacccaggat ttgtttctcc cgttcttttc aaatgtaact tggttccatg     3300

ctatacatgt ttccggaacc aatggaacaa agagatttga taacccagtg ttaccattta     3360

acgacggagt ttatttcgca tcaactgaga aatccaatat cattagaggc tggattttcg     3420

gaacgaccct ggattctaaa acgcaatcct tgctgattgt taataatgca acaaatgtgg     3480

tcattaaagt ctgtgaattc caattttgca atgatccatt tctcggcgtc tattaccaca     3540

agaataacaa atcttggatg gagtcagagt tcagggttta tagttccgca aataattgta     3600

cttttgaata cgtttcccaa ccattcttaa tggacttgga gggaaaacag ggaaatttta     3660

agaatctaag agaattcgtc tttaagaata ttgatggata tttcaagatc tattcaaaac     3720

atacacctat aaacctagtt agagatctcc cgcaagggtt ttcagcccta gagccactag     3780

ttgacctgcc aattgggatc aacattacta gattccagac cctactcgct ctgcatcggt     3840

catatttgac accaggagat tcatcgtcag gatggaccgc tggagcagct gcttactatg     3900

ttgggtatct gcaacctaga acatttctcc taaagtataa tgaaaacggg actattacag     3960

acgcagtcga ttgcgcactg gatccactct cagagacaaa gtgcactcta aaatcattca     4020

ctgtcgagaa aggaatctat caaacatcaa atttcagggt ccagccaact gagagtattg     4080

tccggttccc taacataact aacttgtgcc ccttcggaga ggttttcaat gctactcggt     4140

tcgccagcgt ctacgcatgg aacagaaaga ggatttcaaa ctgtgtcgca gattatagcg     4200

tcctctataa ttcagcatca ttcagtacat ttaaatgcta tggtgtcagc cccaccaaac     4260

ttaatgactt atgttttacc aatgtatatg cagattcctt tgtaatcaga ggtgacgaag     4320

tgaggcaaat cgcacctgga cagaccggaa agattgctga ttataattat aaactccctg     4380

atgattttac cggatgtgtt attgcttgga acagcaataa cctcgatagt aaggtcggag     4440

gaaactataa ctatttgtac agactgttta gaaagtcgaa tttgaaacct tttgaaagag     4500

acatatccac cgagatttac caggcgggca gcacaccgtg taatggtgta gaaggattca     4560

attgttactt tcccctgcaa tcatatgggt ttcaaccaac caatggagtc ggatatcaac     4620

catatcgtgt cgtcgtcctt tccttcgagc tgcttcatgc accagctaca gtctgcggac     4680

ctaagaagag cactaatctt gtcaagaaca aatgtgtgaa ctttaatttt aatggattaa     4740

caggaaccgg agttttgacc gagagtaata agaagttctt gccgttccag caatttggac     4800

gagacattgc tgacaccaca gatgcggttc gtgacccgca aactttagag atcctagaca     4860

tcaccccatg ttcattcggt ggagtttccg ttattactcc tggaacgaat acaagcaatc     4920

aagttgccgt tctctatcaa gatgttaatt gtacagaagt gcctgtggcc attcatgcag     4980

atcaactaac accaacttgg agagtttaca gcactgggtc caatgtcttc caaacgcgcg     5040

ccggctgcct cattggtgca gaacatgtga ataactcata cgaatgtgac attccaatcg     5100

gtgccggcat atgcgcctct taccagactc agactaattc gccaagaaga gccaggtctg     5160

tcgcaagtca gtcaattatt gcatacacaa tgtcgttagg agcagagaat agtgtagcat     5220

actcaaacaa ttctatagca atacctacca acttcactat atcagtaact acagaaatat     5280

tgccagtatc catgactaaa acaagtgtgg attgcaccat gtacatctgt ggagattcca     5340

cagaatgcag caatcttctc ttgcaatacg gatcattctg cacacaactg aatagggcac     5400

tgactggaat tgcagtcgag caggataaga acacacagga ggtgtttgcc caagtcaaac     5460

aaatatacaa aacaccaccc atcaaggatt ttggaggatt taatttctca caaatactcc     5520

ccgacccatc caagccctcc aaaaggagtt tcattgagga cctcttgttt aataaggtta     5580

ccttggcaga tgccgggttt attaagcagt acggcgactg tcttggagac atagcagcca     5640

gagatctaat ttgtgcccag aaattcaatg gactgacagt cctgcctccc ttattaactg     5700

atgagatgat agctcagtat acatcagcat tgttggctgg tacaattaca tctggatgga     5760

catttggtgc cggagcggca ttacaaatcc cttttgcaat gcaaatggcc tatagattta     5820

atggaatcgg agtaactcaa aatgttttat atgagaatca gaaattaatt gcaaatcaat     5880

tcaattcagc tataggaaag attcaggatt cactcagtag tacagcaagc gctctaggca     5940

aattacaaga cgtcgtcaat cagaatgcac aggcattaaa tacactggtg aagcaattga     6000

gttccaattt cggagcaatt tcatctgttc taaatgatat attgtcaaga ctggataaag     6060

tagaagccga ggtccaaatc gataggctga tcacaggaag acttcaatca ctacagacat     6120

acgtcaccca acaactcatc agagcagcag aaattagagc ctctgctaat ctagccgcaa     6180

caaagatgtc agagtgcgta ttgggacaat ctaagagggt cgacttttgt ggaaaggggt     6240

atcacttgat gtcctttcct caatctgcac cacacggagt tgtcttctta catgtaacat     6300

atgtgcccgc tcaagaaaag aatttcacta cagcacctgc aatatgtcat gacggaaaag     6360

cacattttcc tcgggaggga gttttcgttt ctaatggaac ccattggttc gtgacccaaa     6420

ggaactttta cgagcctcaa ataattacaa ctgataatac attcgtttct ggaaattgcg     6480

acgtagttat aggtattgta aataatactg tttatgaccc tttacaacct gaactcgatt     6540

ccttcaagga agaactcgac aaatatttta agaatcacac ctcaccggac gttgacttag     6600

gagacatttc cgggattaac gctagtgtag tcaatatcca aaaggagata gatagactga     6660

atgaggtagc aaagaatctt aatgaatctt tgatcgacct tcaggagctg gggaagtacg     6720

aacaatacat aaaatggcca tggtacattt ggctcgggtt tattgctgga ctaattgcaa     6780

tagtcatggt cactatcatg ctgtgttgta tgacatcgtg ctgctcatgc ctcaagggat     6840

gttgtagctg tggatcttgt tgcaagttcg atgaggatga ttcagaacca gttttaaaag     6900

gagtaaagtt gcattacaca taaaggctag ctgtttacgc gttatccatg ctcaaagagg     6960

cctcaattat atttgagttt ttaattttta tgaaaaaaaa ctaacagcaa tcatggaagt     7020

ccacgatttt gagaccgacg agttcaatga tttcaatgaa gatgactatg ccacaagaga     7080

attcctgaat cccgatgagc gcatgacgta cttgaatcat gctgattaca acctgaattc     7140

tcctctaatt agtgatgata ttgacaattt aatcaggaaa ttcaattctc ttccaattcc     7200

ctcgatgtgg gatagtaaga actgggatgg agttcttgag atgttaacgt catgtcaagc     7260

caatcccatc ccaacatctc agatgcataa atggatggga agttggttaa tgtctgataa     7320

tcatgatgcc agtcaagggt atagtttttt acatgaagtg gacaaagagg cagaaataac     7380

atttgacgtg gtggagacct tcatccgcgg ctggggcaac aaaccaattg aatacatcaa     7440

aaaggaaaga tggactgact cattcaaaat tctcgcttat ttgtgtcaaa agtttttgga     7500

cttacacaag ttgacattaa tcttaaatgc tgtctctgag gtggaattgc tcaacttggc     7560

gaggactttc aaaggcaaag tcagaagaag ttctcatgga acgaacatat gcaggattag     7620

ggttcccagc ttgggtccta cttttatttc agaaggatgg gcttacttca agaaacttga     7680

tattctaatg gaccgaaact ttctgttaat ggtcaaagat gtgattatag ggaggatgca     7740

aacggtgcta tccatggtat gtagaataga caacctgttc tcagagcaag acatcttctc     7800

ccttctaaat atctacagaa ttggagataa aattgtggag aggcagggaa atttttctta     7860

tgacttgatt aaaatggtgg aaccgatatg caacttgaag ctgatgaaat tagcaagaga     7920

atcaaggcct ttagtcccac aattccctca ttttgaaaat catatcaaga cttctgttga     7980

tgaaggggca aaaattgacc gaggtataag attcctccat gatcagataa tgagtgtgaa     8040

aacagtggat ctcacactgg tgatttatgg atcgttcaga cattggggtc atccttttat     8100

agattattac actggactag aaaaattaca ttcccaagta accatgaaga aagatattga     8160

tgtgtcatat gcaaaagcac ttgcaagtga tttagctcgg attgttctat ttcaacagtt     8220

caatgatcat aaaaagtggt tcgtgaatgg agacttgctc cctcatgatc atccctttaa     8280

aagtcatgtt aaagaaaata catggcccac agctgctcaa gttcaagatt ttggagataa     8340

atggcatgaa cttccgctga ttaaatgttt tgaaataccc gacttactag acccatcgat     8400

aatatactct gacaaaagtc attcaatgaa taggtcagag gtgttgaaac atgtccgaat     8460

gaatccgaac actcctatcc ctagtaaaaa ggtgttgcag actatgttgg acacaaaggc     8520

taccaattgg aaagaatttc ttaaagagat tgatgagaag ggcttagatg atgatgatct     8580

aattattggt cttaaaggaa aggagaggga actgaagttg gcaggtagat ttttctccct     8640

aatgtcttgg aaattgcgag aatactttgt aattaccgaa tatttgataa agactcattt     8700

cgtccctatg tttaaaggcc tgacaatggc ggacgatcta actgcagtca ttaaaaagat     8760

gttagattcc tcatccggcc aaggattgaa gtcatatgag gcaatttgca tagccaatca     8820

cattgattac gaaaaatgga ataaccacca aaggaagtta tcaaacggcc cagtgttccg     8880

agttatgggc cagttcttag gttatccatc cttaatcgag agaactcatg aattttttga     8940

gaaaagtctt atatactaca atggaagacc agacttgatg cgtgttcaca acaacacact     9000

gatcaattca acctcccaac gagtttgttg gcaaggacaa gagggtggac tggaaggtct     9060

acggcaaaaa ggatggagta tcctcaatct actggttatt caaagagagg ctaaaatcag     9120

aaacactgct gtcaaagtct tggcacaagg tgataatcaa gttatttgca cacagtataa     9180

aacgaagaaa tcgagaaacg ttgtagaatt acagggtgct ctcaatcaaa tggtttctaa     9240

taatgagaaa attatgactg caatcaaaat agggacaggg aagttaggac ttttgataaa     9300

tgacgatgag actatgcaat ctgcagatta cttgaattat ggaaaaatac cgattttccg     9360

tggagtgatt agagggttag agaccaagag atggtcacga gtgacttgtg tcaccaatga     9420

ccaaataccc acttgtgcta atataatgag ctcagtttcc acaaatgctc tcaccgtagc     9480

tcattttgct gagaacccaa tcaatgccat gatacagtac aattattttg ggacatttgc     9540

tagactcttg ttgatgatgc atgatcctgc tcttcgtcaa tcattgtatg aagttcaaga     9600

taagatacca ggcttgcaca gttctacttt caaatacgcc atgttgtatt tggacccttc     9660

cattggagga gtgtcgggca tgtctttgtc caggtttttg attagagcct tcccagatcc     9720

cgtaacagaa agtctctcat tctggagatt catccatgta catgctcgaa gtgagcatct     9780

gaaggagatg agtgcagtat ttggaaaccc cgagatagcc aagtttcgaa taactcacat     9840

agacaagcta gtagaagatc caacctctct gaacatcgct atgggaatga gtccagcgaa     9900

cttgttaaag actgaggtta aaaaatgctt aatcgaatca agacaaacca tcaggaacca     9960

ggtgattaag gatgcaacca tatatttgta tcatgaagag gatcggctca gaagtttctt    10020

atggtcaata aatcctctgt tccctagatt tttaagtgaa ttcaaatcag gcactttttt    10080

gggagtcgca gacgggctca tcagtctatt tcaaaattct cgtactattc ggaactcctt    10140

taagaaaaag tatcataggg aattggatga tttgattgtg aggagtgagg tatcctcttt    10200

gacacattta gggaaacttc atttgagaag gggatcatgt aaaatgtgga catgttcagc    10260

tactcatgct gacacattaa gatacaaatc ctggggccgt acagttattg ggacaactgt    10320

accccatcca ttagaaatgt tgggtccaca acatcgaaaa gagactcctt gtgcaccatg    10380

taacacatca gggttcaatt atgtttctgt gcattgtcca gacgggatcc atgacgtctt    10440

tagttcacgg ggaccattgc ctgcttatct agggtctaaa acatctgaat ctacatctat    10500

tttgcagcct tgggaaaggg aaagcaaagt cccactgatt aaaagagcta cacgtcttag    10560

agatgctatc tcttggtttg ttgaacccga ctctaaacta gcaatgacta tactttctaa    10620

catccactct ttaacaggcg aagaatggac caaaaggcag catgggttca aaagaacagg    10680

gtctgccctt cataggtttt cgacatctcg gatgagccat ggtgggttcg catctcagag    10740

cactgcagca ttgaccaggt tgatggcaac tacagacacc atgagggatc tgggagatca    10800

gaatttcgac tttttattcc aagcaacgtt gctctatgct caaattacca ccactgttgc    10860

aagagacgga tggatcacca gttgtacaga tcattatcat attgcctgta agtcctgttt    10920

gagacccata gaagagatca ccctggactc aagtatggac tacacgcccc cagatgtatc    10980

ccatgtgctg aagacatgga ggaatgggga aggttcgtgg ggacaagaga taaaacagat    11040

ctatccttta gaagggaatt ggaagaattt agcacctgct gagcaatcct atcaagtcgg    11100

cagatgtata ggttttctat atggagactt ggcgtataga aaatctactc atgccgagga    11160

cagttctcta tttcctctat ctatacaagg tcgtattaga ggtcgaggtt tcttaaaagg    11220

gttgctagac ggattaatga gagcaagttg ctgccaagta atacaccgga gaagtctggc    11280

tcatttgaag aggccggcca acgcagtgta cggaggtttg atttacttga ttgataaatt    11340

gagtgtatca cctccattcc tttctcttac tagatcagga cctattagag acgaattaga    11400

aacgattccc cacaagatcc caacctccta tccgacaagc aaccgtgata tgggggtgat    11460

tgtcagaaat tacttcaaat accaatgccg tctaattgaa aagggaaaat acagatcaca    11520

ttattcacaa ttatggttat tctcagatgt cttatccata gacttcattg gaccattctc    11580

tatttccacc accctcttgc aaatcctata caagccattt ttatctggga aagataagaa    11640

tgagttgaga gagctggcaa atctttcttc attgctaaga tcaggagagg ggtgggaaga    11700

catacatgtg aaattcttca ccaaggacat attattgtgt ccagaggaaa tcagacatgc    11760

ttgcaagttc gggattgcta aggataataa taaagacatg agctatcccc cttggggaag    11820

ggaatccaga gggacaatta caacaatccc tgtttattat acgaccaccc cttacccaaa    11880

gatgctagag atgcctccaa gaatccaaaa tcccctgctg tccggaatca ggttgggcca    11940

attaccaact ggcgctcatt ataaaattcg gagtatatta catggaatgg gaatccatta    12000

cagggacttc ttgagttgtg gagacggctc cggagggatg actgctgcat tactacgaga    12060

aaatgtgcat agcagaggaa tattcaatag tctgttagaa ttatcagggt cagtcatgcg    12120

aggcgcctct cctgagcccc ccagtgccct agaaacttta ggaggagata aatcgagatg    12180

tgtaaatggt gaaacatgtt gggaatatcc atctgactta tgtgacccaa ggacttggga    12240

ctatttcctc cgactcaaag caggcttggg gcttcaaatt gatttaattg taatggatat    12300

ggaagttcgg gattcttcta ctagcctgaa aattgagacg aatgttagaa attatgtgca    12360

ccggattttg gatgagcaag gagttttaat ctacaagact tatggaacat atatttgtga    12420

gagcgaaaag aatgcagtaa caatccttgg tcccatgttc aagacggtcg acttagttca    12480

aacagaattt agtagttctc aaacgtctga agtatatatg gtatgtaaag gtttgaagaa    12540

attaatcgat gaacccaatc ccgattggtc ttccatcaat gaatcctgga aaaacctgta    12600

cgcattccag tcatcagaac aggaatttgc cagagcaaag aaggttagta catactttac    12660

cttgacaggt attccctccc aattcattcc tgatcctttt gtaaacattg agactatgct    12720

acaaatattc ggagtaccca cgggtgtgtc tcatgcggct gccttaaaat catctgatag    12780

acctgcagat ttattgacca ttagcctttt ttatatggcg attatatcgt attataacat    12840

caatcatatc agagtaggac cgatacctcc gaacccccca tcagatggaa ttgcacaaaa    12900

tgtggggatc gctataactg gtataagctt ttggctgagt ttgatggaga aagacattcc    12960

actatatcaa cagtgtttag cagttatcca gcaatcattc ccgattaggt gggaggctgt    13020

ttcagtaaaa ggaggataca agcagaagtg gagtactaga ggtgatgggc tcccaaaaga    13080

tacccgaatt tcagactcct tggccccaat cgggaactgg atcagatctc tggaattggt    13140

ccgaaaccaa gttcgtctaa atccattcaa tgagatcttg ttcaatcagc tatgtcgtac    13200

agtggataat catttgaaat ggtcaaattt gcgaagaaac acaggaatga ttgaatggat    13260

caatagacga atttcaaaag aagaccggtc tatactgatg ttgaagagtg acctacacga    13320

ggaaaactct tggagagatt aaaaaatcat gaggagactc caaactttaa gtatgaaaaa    13380

aactttgatc cttaagaccc tcttgtggtt tttatttttt atctggtttt gtggtcttcg    13440

t                                                                    13441


<210>  160
<211>  9606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence for Vector A, which is a VSV 
       vector without the VSV-G gene.

<400>  160
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttacg cgctagtgga tcctactcga ggctagctgt ttacgcgtta tccatgctca     3120

aagaggcctc aattatattt gagtttttaa tttttatgaa aaaaactaac agcaatcatg     3180

gaagtccacg attttgagac cgacgagttc aatgatttca atgaagatga ctatgccaca     3240

agagaattcc tgaatcccga tgagcgcatg acgtacttga atcatgctga ttacaacctg     3300

aattctcctc taattagtga tgatattgac aatttaatca ggaaattcaa ttctcttcca     3360

attccctcga tgtgggatag taagaactgg gatggagttc ttgagatgtt aacgtcatgt     3420

caagccaatc ccatcccaac atctcagatg cataaatgga tgggaagttg gttaatgtct     3480

gataatcatg atgccagtca agggtatagt tttttacatg aagtggacaa agaggcagaa     3540

ataacatttg acgtggtgga gaccttcatc cgcggctggg gcaacaaacc aattgaatac     3600

atcaaaaagg aaagatggac tgactcattc aaaattctcg cttatttgtg tcaaaagttt     3660

ttggacttac acaagttgac attaatctta aatgctgtct ctgaggtgga attgctcaac     3720

ttggcgagga ctttcaaagg caaagtcaga agaagttctc atggaacgaa catatgcagg     3780

attagggttc ccagcttggg tcctactttt atttcagaag gatgggctta cttcaagaaa     3840

cttgatattc taatggaccg aaactttctg ttaatggtca aagatgtgat tatagggagg     3900

atgcaaacgg tgctatccat ggtatgtaga atagacaacc tgttctcaga gcaagacatc     3960

ttctcccttc taaatatcta cagaattgga gataaaattg tggagaggca gggaaatttt     4020

tcttatgact tgattaaaat ggtggaaccg atatgcaact tgaagctgat gaaattagca     4080

agagaatcaa ggcctttagt cccacaattc cctcattttg aaaatcatat caagacttct     4140

gttgatgaag gggcaaaaat tgaccgaggt ataagattcc tccatgatca gataatgagt     4200

gtgaaaacag tggatctcac actggtgatt tatggatcgt tcagacattg gggtcatcct     4260

tttatagatt attacactgg actagaaaaa ttacattccc aagtaaccat gaagaaagat     4320

attgatgtgt catatgcaaa agcacttgca agtgatttag ctcggattgt tctatttcaa     4380

cagttcaatg atcataaaaa gtggttcgtg aatggagact tgctccctca tgatcatccc     4440

tttaaaagtc atgttaaaga aaatacatgg cccacagctg ctcaagttca agattttgga     4500

gataaatggc atgaacttcc gctgattaaa tgttttgaaa tacccgactt actagaccca     4560

tcgataatat actctgacaa aagtcattca atgaataggt cagaggtgtt gaaacatgtc     4620

cgaatgaatc cgaacactcc tatccctagt aaaaaggtgt tgcagactat gttggacaca     4680

aaggctacca attggaaaga atttcttaaa gagattgatg agaagggctt agatgatgat     4740

gatctaatta ttggtcttaa aggaaaggag agggaactga agttggcagg tagatttttc     4800

tccctaatgt cttggaaatt gcgagaatac tttgtaatta ccgaatattt gataaagact     4860

catttcgtcc ctatgtttaa aggcctgaca atggcggacg atctaactgc agtcattaaa     4920

aagatgttag attcctcatc cggccaagga ttgaagtcat atgaggcaat ttgcatagcc     4980

aatcacattg attacgaaaa atggaataac caccaaagga agttatcaaa cggcccagtg     5040

ttccgagtta tgggccagtt cttaggttat ccatccttaa tcgagagaac tcatgaattt     5100

tttgagaaaa gtcttatata ctacaatgga agaccagact tgatgcgtgt tcacaacaac     5160

acactgatca attcaacctc ccaacgagtt tgttggcaag gacaagaggg tggactggaa     5220

ggtctacggc aaaaaggatg gagtatcctc aatctactgg ttattcaaag agaggctaaa     5280

atcagaaaca ctgctgtcaa agtcttggca caaggtgata atcaagttat ttgcacacag     5340

tataaaacga agaaatcgag aaacgttgta gaattacagg gtgctctcaa tcaaatggtt     5400

tctaataatg agaaaattat gactgcaatc aaaataggga cagggaagtt aggacttttg     5460

ataaatgacg atgagactat gcaatctgca gattacttga attatggaaa aataccgatt     5520

ttccgtggag tgattagagg gttagagacc aagagatggt cacgagtgac ttgtgtcacc     5580

aatgaccaaa tacccacttg tgctaatata atgagctcag tttccacaaa tgctctcacc     5640

gtagctcatt ttgctgagaa cccaatcaat gccatgatac agtacaatta ttttgggaca     5700

tttgctagac tcttgttgat gatgcatgat cctgctcttc gtcaatcatt gtatgaagtt     5760

caagataaga taccaggctt gcacagttct actttcaaat acgccatgtt gtatttggac     5820

ccttccattg gaggagtgtc gggcatgtct ttgtccaggt ttttgattag agccttccca     5880

gatcccgtaa cagaaagtct ctcattctgg agattcatcc atgtacatgc tcgaagtgag     5940

catctgaagg agatgagtgc agtatttgga aaccccgaga tagccaagtt tcgaataact     6000

cacatagaca agctagtaga agatccaacc tctctgaaca tcgctatggg aatgagtcca     6060

gcgaacttgt taaagactga ggttaaaaaa tgcttaatcg aatcaagaca aaccatcagg     6120

aaccaggtga ttaaggatgc aaccatatat ttgtatcatg aagaggatcg gctcagaagt     6180

ttcttatggt caataaatcc tctgttccct agatttttaa gtgaattcaa atcaggcact     6240

tttttgggag tcgcagacgg gctcatcagt ctatttcaaa attctcgtac tattcggaac     6300

tcctttaaga aaaagtatca tagggaattg gatgatttga ttgtgaggag tgaggtatcc     6360

tctttgacac atttagggaa acttcatttg agaaggggat catgtaaaat gtggacatgt     6420

tcagctactc atgctgacac attaagatac aaatcctggg gccgtacagt tattgggaca     6480

actgtacccc atccattaga aatgttgggt ccacaacatc gaaaagagac tccttgtgca     6540

ccatgtaaca catcagggtt caattatgtt tctgtgcatt gtccagacgg gatccatgac     6600

gtctttagtt cacggggacc attgcctgct tatctagggt ctaaaacatc tgaatctaca     6660

tctattttgc agccttggga aagggaaagc aaagtcccac tgattaaaag agctacacgt     6720

cttagagatg ctatctcttg gtttgttgaa cccgactcta aactagcaat gactatactt     6780

tctaacatcc actctttaac aggcgaagaa tggaccaaaa ggcagcatgg gttcaaaaga     6840

acagggtctg cccttcatag gttttcgaca tctcggatga gccatggtgg gttcgcatct     6900

cagagcactg cagcattgac caggttgatg gcaactacag acaccatgag ggatctggga     6960

gatcagaatt tcgacttttt attccaagca acgttgctct atgctcaaat taccaccact     7020

gttgcaagag acggatggat caccagttgt acagatcatt atcatattgc ctgtaagtcc     7080

tgtttgagac ccatagaaga gatcaccctg gactcaagta tggactacac gcccccagat     7140

gtatcccatg tgctgaagac atggaggaat ggggaaggtt cgtggggaca agagataaaa     7200

cagatctatc ctttagaagg gaattggaag aatttagcac ctgctgagca atcctatcaa     7260

gtcggcagat gtataggttt tctatatgga gacttggcgt atagaaaatc tactcatgcc     7320

gaggacagtt ctctatttcc tctatctata caaggtcgta ttagaggtcg aggtttctta     7380

aaagggttgc tagacggatt aatgagagca agttgctgcc aagtaataca ccggagaagt     7440

ctggctcatt tgaagaggcc ggccaacgca gtgtacggag gtttgattta cttgattgat     7500

aaattgagtg tatcacctcc attcctttct cttactagat caggacctat tagagacgaa     7560

ttagaaacga ttccccacaa gatcccaacc tcctatccga caagcaaccg tgatatgggg     7620

gtgattgtca gaaattactt caaataccaa tgccgtctaa ttgaaaaggg aaaatacaga     7680

tcacattatt cacaattatg gttattctca gatgtcttat ccatagactt cattggacca     7740

ttctctattt ccaccaccct cttgcaaatc ctatacaagc catttttatc tgggaaagat     7800

aagaatgagt tgagagagct ggcaaatctt tcttcattgc taagatcagg agaggggtgg     7860

gaagacatac atgtgaaatt cttcaccaag gacatattat tgtgtccaga ggaaatcaga     7920

catgcttgca agttcgggat tgctaaggat aataataaag acatgagcta tcccccttgg     7980

ggaagggaat ccagagggac aattacaaca atccctgttt attatacgac caccccttac     8040

ccaaagatgc tagagatgcc tccaagaatc caaaatcccc tgctgtccgg aatcaggttg     8100

ggccaattac caactggcgc tcattataaa attcggagta tattacatgg aatgggaatc     8160

cattacaggg acttcttgag ttgtggagac ggctccggag ggatgactgc tgcattacta     8220

cgagaaaatg tgcatagcag aggaatattc aatagtctgt tagaattatc agggtcagtc     8280

atgcgaggcg cctctcctga gccccccagt gccctagaaa ctttaggagg agataaatcg     8340

agatgtgtaa atggtgaaac atgttgggaa tatccatctg acttatgtga cccaaggact     8400

tgggactatt tcctccgact caaagcaggc ttggggcttc aaattgattt aattgtaatg     8460

gatatggaag ttcgggattc ttctactagc ctgaaaattg agacgaatgt tagaaattat     8520

gtgcaccgga ttttggatga gcaaggagtt ttaatctaca agacttatgg aacatatatt     8580

tgtgagagcg aaaagaatgc agtaacaatc cttggtccca tgttcaagac ggtcgactta     8640

gttcaaacag aatttagtag ttctcaaacg tctgaagtat atatggtatg taaaggtttg     8700

aagaaattaa tcgatgaacc caatcccgat tggtcttcca tcaatgaatc ctggaaaaac     8760

ctgtacgcat tccagtcatc agaacaggaa tttgccagag caaagaaggt tagtacatac     8820

tttaccttga caggtattcc ctcccaattc attcctgatc cttttgtaaa cattgagact     8880

atgctacaaa tattcggagt acccacgggt gtgtctcatg cggctgcctt aaaatcatct     8940

gatagacctg cagatttatt gaccattagc cttttttata tggcgattat atcgtattat     9000

aacatcaatc atatcagagt aggaccgata cctccgaacc ccccatcaga tggaattgca     9060

caaaatgtgg ggatcgctat aactggtata agcttttggc tgagtttgat ggagaaagac     9120

attccactat atcaacagtg tttagcagtt atccagcaat cattcccgat taggtgggag     9180

gctgtttcag taaaaggagg atacaagcag aagtggagta ctagaggtga tgggctccca     9240

aaagataccc gaatttcaga ctccttggcc ccaatcggga actggatcag atctctggaa     9300

ttggtccgaa accaagttcg tctaaatcca ttcaatgaga tcttgttcaa tcagctatgt     9360

cgtacagtgg ataatcattt gaaatggtca aatttgcgaa gaaacacagg aatgattgaa     9420

tggatcaata gacgaatttc aaaagaagac cggtctatac tgatgttgaa gagtgaccta     9480

cacgaggaaa actcttggag agattaaaaa atcatgagga gactccaaac tttaagtatg     9540

aaaaaaactt tgatccttaa gaccctcttg tggtttttat tttttatctg gttttgtggt     9600

cttcgt                                                                9606


<210>  161
<211>  9490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence for Vector B, which is a VSV 
       vector without the VSV-G gene.

<400>  161
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcatagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attgaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaggcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggtgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaggct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtgac gacctggatc ttgaaccgag aagttgcaga tgagatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggctgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgctg acttggcaca acagttttgt gttggagata gcaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaacga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagag     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta gctatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctagatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggacggagtg gaagagcata ctaggccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gtaccagatc cggaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg acgtggatgt tgtattcact tcggactgga aacagcctga gcttgaatcc     1740

gacgagcatg gaaagacctt acggttgaca ttgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc ttttgacgat taaagcagtc gttcaaagtg ccaaacactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcatcataa aaaagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agccgtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagaattcat ctctgtcgga     2100

ggtaacggac gaatgtctca taaagaggcc atcctgctcg gtctgaggta caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactagta tgaaaaaaag taacagatat     2220

cacaatctaa gtgttatccc aatccattca tcatgagttc cttaaagaag attctcggtc     2280

tgaaggggaa aggtaagaaa tctaagaaat tagggatcgc accaccccct tatgaagagg     2340

acactaacat ggagtatgct ccgagcgctc caattgacaa atcctatttt ggagttgacg     2400

agatggacac tcatgatccg aatcaattaa gatatgagaa attcttcttt acagtgaaaa     2460

tgacggttag atctaatcgt ccgttcagaa catactcaga tgtggcagcc gctgtatccc     2520

attgggatca catgtacatc ggaatggcag ggaaacgtcc cttctacaag atcttggctt     2580

ttttgggttc ttctaatcta aaggccactc cagcggtatt ggcagatcaa ggtcaaccag     2640

agtatcatgc tcactgtgaa ggcagggctt atttgccaca cagaatgggg aagacccctc     2700

ccatgctcaa tgtaccagag cacttcagaa gaccattcaa tataggtctt tacaagggaa     2760

cgattgagct cacaatgacc atctacgatg atgagtcact ggaagcagct cctatgatct     2820

gggatcattt caattcttcc aaattttctg atttcagaga gaaggcctta atgtttggcc     2880

tgattgtcga gaaaaaggca tctggagctt gggtcctgga ttctgtcagc cacttcaaat     2940

gagctagtct agcttccagc ttctgaacaa tccccggttt actcagtctc tcctaattcc     3000

agcctttcga attaattaaa ttttaatttt taatttttat gaaaaaaaac taacagcaat     3060

catggaagtc cacgattttg agaccgacga gttcaatgat ttcaatgaag atgactatgc     3120

cacaagagaa ttcctgaatc ccgatgagcg catgacgtac ttgaatcatg ctgattacaa     3180

tttgaattct cctctaatta gtgatgatat tgacaatttg atcaggaaat tcaattctct     3240

tccgattccc tcgatgtggg atagtaagaa ctgggatgga gttcttgaga tgttaacatc     3300

atgtcaagcc aatcccatct caacatctca gatgcataaa tggatgggaa gttggttaat     3360

gtctgataat catgatgcca gacaagggta tagtttttta catgaagtgg acaaagaggc     3420

agaaataaca tttgacgtgg tggagacctt catccgcggc tggggcaaca aaccaattga     3480

atacatcaaa aaggaaagat ggactgactc attcaaaatt ctcgcttatt tgtgtcaaaa     3540

gtttttggac ttacacaagt tgacattaat cttaaatgct gtctctgagg tggaattgct     3600

caacttggcg aggactttca aaggcaaagt cagaagaagt tctcatggaa cgaacatatg     3660

caggcttagg gttcccagct tgggtcctac ttttatttca gaaggatggg cttacttcaa     3720

gaaacttgat attctaatgg accgaaactt tctgttaatg gtcaaagatg tgattatagg     3780

gaggatgcaa acggtgctat ccatggtatg tagaatagac aacctgttct cagagcaaga     3840

catcttctcc cttctaaata tctacagaat tggagataaa attgtggaga ggcagggaaa     3900

tttttcttat gacttgatta aaatggtgga accgatatgc aacttgaagc tgatgaaatt     3960

agcaagagaa tcaaggcctt tagtcccaca attccctcat tttgaaaatc atatcaagac     4020

ttctgttgat gaaggggcaa aaattgaccg aggtataaga ttcctccatg atcagataat     4080

gagtgtgaaa acagtggatc tcacactggt gatttatgga tcgttcagac attggggtca     4140

tccttttata gattattacg ctggactaga aaaattacat tcccaagtaa ccatgaagaa     4200

agatattgat gtgtcatatg caaaagcact tgcaagtgat ttagctcgga ttgttctatt     4260

tcaacagttc aatgatcata aaaagtggtt cgtgaatgga gacttgctcc ctcatgatca     4320

tccctttaaa agtcatgtta aagaaaatac atggcctaca gctgctcaag ttcaagattt     4380

tggagataaa tggcatgaac ttccgctgat taaatgtttt gaaatacccg acttactaga     4440

cccatcgata atatactctg acaaaagtca ttcaatgaat aggtcagagg tgttgaaaca     4500

tgtccgaatg aatccgaaca ctcctatccc tagtaaaaag gtgttgcaga ctatgttgga     4560

cacaaaggct accaattgga aagaatttct taaagagatt gatgagaagg gcttagatga     4620

tgatgatcta attattggtc ttaaaggaaa ggagagggaa ctgaagttgg caggtagatt     4680

tttctcccta atgtcttgga aattgcgaga atactttgta attaccgaat atttgataaa     4740

gactcatttc gtccctatgt ttaaaggcct gacaatggcg gacgatctaa ctgcagtcat     4800

taaaaagatg ttagattcct catccggcca aggattgaag tcatatgagg caatttgcat     4860

agccaatcac attgattacg aaaaatggaa taaccaccaa aggaagttat caaacggccc     4920

agtgttccga gttatgggcc agttcttagg ttatccatcc ttaatcgaga gaactcatga     4980

attttttgag aaaagtctta tatactacaa tggaagacca gacttgatgc gtgttcacaa     5040

caacacactg atcaattcaa cctcccaacg agtttgttgg caaggacaag agggtggact     5100

ggaaggtcta cggcaaaaag gatggagtat cctcaatcta ctggttattc aaagagaggc     5160

taaaatcaga aacactgctg tcaaagtctt ggcacaaggt gataatcaag ttatttgcac     5220

acagtataaa acgaagaaat cgagaaacgt tgtagaatta cagggtgctc tcaatcaaat     5280

ggtttctaat aatgagaaaa ttatgactgc aatcaaaata gggacaggga agttaggact     5340

tttgataaat gacgatgaga ctatgcaatc tgcagattac ttgaattatg gaaaaatacc     5400

gattttccgt ggagtgatta gagggttaga gaccaagaga tggtcacgag tgacttgtgt     5460

caccaatgac caaataccca cttgtgctaa tataatgagc tcagtttcca caaatgctct     5520

caccgtagct cattttgctg agaacccaat caatgccatg atacagtaca attattttgg     5580

gacatttgct agactcttgt tgatgatgca tgatcctgct cttcgtcaat cattgtatga     5640

agttcaagat aagataccgg gcttgcacag ttctactttc aaatacgcca tgttgtattt     5700

ggacccttcc attggaggag tgtcgggcat gtctttgtcc aggtttttga ttagagcctt     5760

cccagatccc gtaacagaaa gtctctcatt ctggagattc atccatgtac atgctcgaag     5820

tgagcatctg aaggagatga gtgcagtatt tggaaacccc gagatagcca agttccgaat     5880

aactcacata gacaagctag tagaagatcc aacctctctg aacatcgcta tgggaatgag     5940

tccagcgaac ttgttaaaga ctgaggttaa aaaatgctta atcgaatcaa gacaaaccat     6000

caggaaccag gtgattaagg atgcaaccat atatttgtat catgaagagg atcggctcag     6060

aagtttctta tggtcaataa atcctctgtt ccctagattt ttaagtgaat tcaaatcagg     6120

cacttttttg ggagtcgcag acgggctcat cagtctattt caaaattctc gtactattcg     6180

gaactccttt aagaaaaagt atcataggga attggatgat ttgattgtga ggagtgaggt     6240

atcctctttg acacatttag ggaaacttca tttgagaagg ggatcatgta aaatgtggac     6300

atgttcagct actcatgctg acacattaag atacaaatcc tggggccgta cagttattgg     6360

gacaactgta ccccatccat tagaaatgtt gggtccacaa catcgaaaag agactccttg     6420

tgcaccatgt aacacatcag ggttcaatta tgtttctgtg cattgtccag acgggatcca     6480

tgacgtcttt agttcacggg gaccattgcc tgcttatcta gggtctaaaa catctgaatc     6540

tacatctatt ttgcagcctt gggaaaggga aagcaaagtc ccactgatta aaagagctac     6600

acgtcttaga gatgctatct cttggtttgt tgaacccgac tctaaactag caatgactat     6660

actttctaac atccactctt taacaggcga agaatggacc gaaaggcagc atgggttcaa     6720

aagaacaggg tctgcccttc ataggttttc gacatctcgg atgagccatg gtgggttcgc     6780

atctcagagc actgcagcat tgaccaggtt gatggcaact acagacacca tgagggatct     6840

gggagatcag aatttcgact ttttattcca agcaacgttg ctctatgctc aaattaccac     6900

cactgttgca agagacggat ggatcaccag ttgtacagat cattatcata ttgcctgtaa     6960

gtcctgtttg agacccatag aagagatcac cctggactca agtatggact acacgccccc     7020

agatgtatcc catgtgctga agacatggag gaatggggaa ggttcgtggg gacaagagat     7080

aaaacagatc tatcctttag aagggaattg gaagaattta gcacctgctg agcaatccta     7140

tcaagtcggc agatgtatag gttttctata tggagacttg gcgtatagaa aatctactca     7200

tgccgaggac agttctctat ttcctctatc tatacaaggt cgtattagag gtcgaggttt     7260

cttaaaaggg ttgctagacg gattaatgag agcaagttgc tgccaagtaa tacaccggag     7320

aagtctggct catttgaaga ggccggccaa cgcagtgtac ggaggtttga tttacttgat     7380

tgataaattg agtgtatcac ctccattcct ttctcttact agatcaggac ctattagaga     7440

cgaattagaa acgattcccc acaagatccc aacctcctat ccgacaagca accgtgatat     7500

gggggtgatt gtcagaaatt acttcaaata ccaatgccgt ctaattgaaa agggaaaata     7560

cagatcacat tattcacaat tatggttatt ctcagatgtc ttatccatag acttcattgg     7620

accattctct atttccacca ccctcttgca aatcctatac aagccatttt tatctgggaa     7680

agataagaat gagttgagag agctggcaaa tctttcttca ttgctaagat caggagaggg     7740

gtgggaagac atacatgtga aattcttcac caaggacata ttattgtgtc cagaggaaat     7800

cagacatgct tgcaagttcg ggattgctaa ggataataat aaagacatga gctatccccc     7860

ttggggaagg gaatccagag ggacaattac aacaatccct gtttattata cgaccacccc     7920

ttacccaaag atgctagaga tgcctccaag aatccaaaat cccctgctgt ccggaatcag     7980

gttgggccaa ttaccaactg gcgctcatta taaaattcgg agtatattac atggaatggg     8040

aatccattac agggacttct tgagttgtgg agacggctcc ggagggatga ctgctgcatt     8100

actacgagaa aatgtgcata gcagaggaat attcaatagt ctgttagaat tatcagggtc     8160

agtcatgcga ggcgcctctc ctgagccccc cagtgcccta gaaactttag gaggagataa     8220

atcgagatgt gtaaatggtg aaacatgttg ggaatatcca tctgacttat gtgacccaag     8280

gacttgggac tatttcctcc gactcaaagc aggcttgggg cttcaaattg atttaattgt     8340

aatggatatg gaagttcggg attcttctac tagcctgaaa attgagacga atgttagaaa     8400

ttatgtgcac cggattttgg atgagcaagg agttttaatc tacaagactt atggaacata     8460

tatttgtgag agcgaaaaga atgcagtaac aatccttggt cccatgttca agacggtcga     8520

cttagttcaa acagaattta gtagttctca aacgtctgaa gtatatatgg tatgtaaagg     8580

tttgaagaaa ttaatcgatg aacccaatcc cgattggtct tccatcaatg aatcctggaa     8640

aaacctgtac gcattccagt catcagaaca ggaatttgcc agagcaaaga aggttagtac     8700

atactttacc ttgacaggta ttccctccca attcattcct gatccttttg taaacattga     8760

gactatgcta caaatattcg gagtacccac gggtgtgtct catgcggctg ccttaaaatc     8820

atctgataga cctgcagatt tattgaccat tagccttttt tatatggcga ttatatcgta     8880

ttataacatc aatcatatca gagtaggacc gatacctccg aaccccccat cagatggaat     8940

tgcacaaaat gtggggatcg ctataactgg tataagcttt tggctgagtt tgatggagaa     9000

agacattcca ctatatcaac agtgtttagc agttatccag caatcattcc cgattaggtg     9060

ggaggctgtt tcagtaaaag gaggatacaa gcagaagtgg agtactagag gtgatgggct     9120

cccaaaagat acccgaattt cagactcctt ggccccaatc gggaactgga tcagatctct     9180

ggaattggtc cgaaaccaag ttcgtctaaa tccattcaat gagatcttgt tcaatcagct     9240

atgtcgtaca gtggataatc atttgaaatg gtcaaatttg cgaaaaaaca caggaatgat     9300

tgaatggatc aatagacgaa tttcaaaaga agaccggtct atactgatgt tgaagagtga     9360

cctacacgag gaaaactctt ggagagatta aaaaatcatg aggagactcc aaactttaag     9420

tatgaaaaaa actttgatcc ttaagaccct cttgtggttt ttatttttta tctggttttg     9480

tggtcttcgt                                                            9490


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the signal sequence (SS) of SEQ
       ID NOS: 1, 4, 7, 10, 13, 16, 19, and 22

<400>  162

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
1               5                   10                  15  


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the membrane-proximal external 
       region (MPER) of SEQ ID NOS: 1, 4, 7, 10, and 16

<400>  163

Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp 
1               5                   10          


<210>  164
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the transmembrane region (TM) 
       of SEQ ID NOS: 1, 4, 7, and 16

<400>  164

Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 
1               5                   10                  15      


Leu 
    


<210>  165
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the cytoplasmic tail (CT) of 
       SEQ ID NO: 1

<400>  165

Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys 
1               5                   10                  15      


Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys 
            20                  25                  30          


Gly Val Lys Leu His Tyr Thr 
        35                  


<210>  166
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Kozak sequence of SEQ ID NOS: 2, 3, 5, 6, 8, 9, 11, 
       12, 14, 15, 17, 18, 20, 21, 23, and 24

<400>  166
aggagccacc                                                              10


<210>  167
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the SS of SEQ ID NOS: 2, 
       3, 5, 6, 8, 9, 11, 12, 14, 15, 17, 18, 20, 21, 23, and 24

<400>  167
atgttcgtgt tcctggtgct attacctctg gtttcgtctc aatgc                       45


<210>  168
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the MPER of SEQ ID NOS: 
       2, 3, 5, 6, 8, 9, 11, 12, 17, and 18

<400>  168
tacgaacaat acataaaatg gccatggtac atttgg                                 36


<210>  169
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the TM of SEQ ID NOS: 2, 
       3, 5, 6, 8, 9, 17, and 18

<400>  169
ctcgggttta ttgctggact aattgcaata gtcatggtca ctatcatgct g                51


<210>  170
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the CT of SEQ ID NOS: 2 
       and 3

<400>  170
tgttgtatga catcgtgctg ctcatgcctc aagggatgtt gtagctgtgg atcttgttgc       60

aagttcgatg aggatgattc agaaccagtt ttaaaaggag taaagttgca ttacaca         117


<210>  171
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the CT of SEQ ID NO: 4

<400>  171

Cys Cys Met Thr Ser Cys Cys Ser 
1               5               


<210>  172
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the CT of SEQ ID NOS: 5 
       and 6

<400>  172
tgttgtatga catcgtgctg ctca                                              24


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the Vector B VSV-G-CT IND 
       serotype of SEQ ID NOS: 7, 10, 13, and 19

<400>  173

Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
1               5                   10                  15      


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            20                  25                  


<210>  174
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the Vector B VSV-G-CT IND
       serotype sequence of SEQ ID NOS: 8, 9, 11, 12, 14, 15, 20, and 21

<400>  174
cgagttggta tttatctttg cattaaatta aagcacacca agaaaagaca gatttataca       60

gacatagaga tgaaccgact tggaaag                                           87


<210>  175
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the Vector B VSV-G-TM IND 
       serotype of SEQ ID NOS: 10 and 13

<400>  175

Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu 
1               5                   10                  15      


Phe Leu Val Leu 
            20  


<210>  176
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the Vector B VSV-G-TM IND
       serotype sequence of SEQ ID NOS: 11, 12, 14, and 15

<400>  176
agctctattg cctctttttt ctttatcata gggttaatca ttggactatt cttggttctc       60


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the MPER of SEQ ID NOS: 13, 19,
       and 22

<400>  177

Tyr Glu Gln Tyr Ile Lys 
1               5       


<210>  178
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the MPER of SEQ ID NOS: 
       14 and 15

<400>  178
tacgaacaat acataaaa                                                     18


<210>  179
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the CT of SEQ ID NO: 16

<400>  179

Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys 
1               5                   10                  15      


Gly Ser 
        


<210>  180
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the CT of SEQ ID NOS: 17 
       and 18

<400>  180
tgttgtatga catcgtgctg ctcatgcctc aagggatgtt gtagctgtgg atct             54


<210>  181
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the TM of SEQ ID NOS: 19 and 22

<400>  181

Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile 
1               5                   10                  15      


Val Met Val Thr Ile Met Leu 
            20              


<210>  182
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence of the CT of SEQ ID NOS: 19 and 22

<400>  182

Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys 
1               5                   10                  15      


Gly Ser Cys Cys 
            20  


<210>  183
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the TM of SEQ ID NOS: 20,
       21, 23, and 24

<400>  183
tggccatggt acatttggct cgggtttatt gctggactaa ttgcaatagt catggtcact       60

atcatgctg                                                               69


<210>  184
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the CT of SEQ ID NOS: 20,
       21, 23, and 24

<400>  184
tgttgtatga catcgtgctg ctcatgcctc aagggatgtt gtagctgtgg atcttgttgc       60


<210>  185
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Amino acid sequence for the Vector B VSV-G-CT IND 
       serotype of SEQ ID NO: 22

<400>  185

Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
1               5                   10                  15      


Asn Arg Leu Gly Lys 
            20      


<210>  186
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the Vector B VSV-G-CT IND
       serotype sequence of SEQ ID NO: 23 and 24

<400>  186
aaattaaagc acaccaagaa aagacagatt tatacagaca tagagatgaa ccgacttgga       60

aag                                                                     63


<210>  187
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VSV-G-TM-CT segment of Vector A

<400>  187

Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu 
1               5                   10                  15      


Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His 
            20                  25                  30          


Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly 
        35                  40                  45              


Lys 
    


<210>  188
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VSV-G-TM-CT segment of Vector B

<400>  188

Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu 
1               5                   10                  15      


Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His 
            20                  25                  30          


Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly 
        35                  40                  45              


Lys 
    


<210>  189
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Leader sequence 1

<400>  189

Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gly Glu 
1               5                   10                  15      


Leu Gly Lys 
            


<210>  190
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Leader sequence 2

<400>  190

Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe 
1               5                   10                  15      


Val Glu Gly Trp Phe Ser Ser Trp Lys 
            20                  25  


<210>  191
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: A segment of VSV-G

<400>  191

Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe 
1               5                   10                  15      


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
            20                  25                  30          


Phe Thr Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
        35                  40                  45              


Ile Tyr Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr 
    50                  55                  60                  


Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
65                  70                  


<210>  192
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Nucleotide sequence encoding the MPER of SEQ ID NOS: 
       20 and 23

<400>  192
tacgaacaat acataaaa                                                     18


<210>  193
<211>  23
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2

<400>  193

Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys 
1               5                   10                  15      


Gly Val Lys Leu His Tyr Thr 
            20              


<210>  194
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194
gaaaaaaaac                                                              10


