                         SEQUENCE LISTING

<110>  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  CRISPR/CAS9 CORRECTION OF MUTATIONS IN DYSTROPHIN EXONS 43, 45, 
       AND 52

<130>  UTFD.P3757WO

<150>  62/979,790
<151>  2020-02-21

<160>  211   

<170>  PatentIn version 3.5

<210>  1
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  2
<211>  1050
<212>  PRT
<213>  Staphylococcus aureus

<400>  2

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  
    1040                 1045                 1050 


<210>  3
<211>  1307
<212>  PRT
<213>  Acidaminococcus species BV3L6

<400>  3

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  4
<211>  1228
<212>  PRT
<213>  Lachnospiraceae species ND2006

<400>  4

Ala Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Ala Ala Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Ala Ala Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Ala Lys Thr Lys Gln Ala Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Leu Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Ala Ala Ala Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Ala Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1220                 1225             


<210>  5
<211>  5
<212>  DNA
<213>  Streptococcus pyogenes


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  5
ngrrt                                                                    5


<210>  6
<211>  5
<212>  DNA
<213>  Staphylococcus aureus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<400>  6
ngrrn                                                                    5


<210>  7
<211>  8
<212>  DNA
<213>  Neisseria meningitidis


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  7
nnnngatt                                                                 8


<210>  8
<211>  8
<212>  DNA
<213>  Campylobacter jejuni


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  8
nnnnryac                                                                 8


<210>  9
<211>  7
<212>  DNA
<213>  Streptococcus thermophilus


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  9
nnagaaw                                                                  7


<210>  10
<211>  4
<212>  DNA
<213>  Lachnospiraceae bacterium

<400>  10
tttv                                                                     4


<210>  11
<211>  4
<212>  DNA
<213>  Acidaminococcus species BV3L6

<400>  11
tttv                                                                     4


<210>  12
<211>  3685
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Leu Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g1 spacer sequence

<400>  13
atttattttt ccttttattc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g2 spacer sequence

<400>  14
tttcctttta ttctagttga                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g3 spacer sequence

<400>  15
tgattctgaa ttctttcaac                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g4 spacer sequence

<400>  16
aaagaaaatc acagaaacca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g5 spacer sequence

<400>  17
aaaatcacag aaaccaaggt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g6 spacer sequence

<400>  18
ggtatctttg atactaacct                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g7 spacer sequence

<400>  19
tgaaagaatt cagaatcagt                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g8 spacer sequence

<400>  20
actgttgcct ccggttctga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g9 spacer sequence

<400>  21
tacaagaaca ccttcagaac                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g10 spacer sequence

<400>  22
aagaacacct tcagaaccgg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g11 spacer sequence

<400>  23
tttcattcaa ctgttgcctc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g12 spacer sequence

<400>  24
tgttaaagga ttcaacacaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g13 spacer sequence

<400>  25
aaaggattca acacaatggc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g14 spacer sequence

<400>  26
aattcagaat cagtgggatg                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g15 spacer sequence

<400>  27
ttgaaagaat tcagaatcag                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g16 spacer sequence

<400>  28
acagttgaat gaaatgttaa                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g17 spacer sequence

<400>  29
accttcagaa ccggaggcaa                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g18 spacer sequence

<400>  30
aattctttca actagaataa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g19 spacer sequence

<400>  31
ttattctagt tgaaagaatt                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g20 spacer sequence

<400>  32
tagttgaaag aattcagaat                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g21 spacer sequence

<400>  33
atgaagtaca agaacacctt                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g22 spacer sequence

<400>  34
aactgttgcc tccggttctg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g23 spacer sequence

<400>  35
caagaacacc ttcagaaccg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE53g24 spacer sequence

<400>  36
aacagttgaa tgaaatgtta                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g1 spacer sequence

<400>  37
atccatatgc ttttacctgc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g2 spacer sequence

<400>  38
gatccatatg cttttacctg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g3 spacer sequence

<400>  39
cagatctgtc aaatcgcctg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g4 spacer sequence

<400>  40
taaatacaaa tggtatctta                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g5 spacer sequence

<400>  41
agatctgtca aatcgcctgc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g6 spacer sequence

<400>  42
acagatctgt tgagaaatgg                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g7 spacer sequence

<400>  43
ttagcatgtt cccaattctc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g8 spacer sequence

<400>  44
gggaacatgc taaatacaaa                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g9 spacer sequence

<400>  45
ttgacagatc tgttgagaaa                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g10 spacer sequence

<400>  46
agacacaaat tcctgagaat                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g11 spacer sequence

<400>  47
gacacaaatt cctgagaatt                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g12 spacer sequence

<400>  48
cgcctgcagg taaaagcata                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g13 spacer sequence

<400>  49
tttacctgca ggcgatttga                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g14 spacer sequence

<400>  50
ggcgatttga cagatctgtt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g15 spacer sequence

<400>  51
atttaatcag tggctaacag                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g16 spacer sequence

<400>  52
agaaactgtt cagcttctgt                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g17 spacer sequence

<400>  53
agtggctaac agaagctgaa                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g18 spacer sequence

<400>  54
aagctgaaca gtttctcaga                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g19 spacer sequence

<400>  55
tttagcatgt tcccaattct                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g20 spacer sequence

<400>  56
cttaagatac catttgtatt                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g21 spacer sequence

<400>  57
ctaaatacaa atggtatctt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g22 spacer sequence

<400>  58
tacaaatggt atcttaaggt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g23 spacer sequence

<400>  59
acaaatcaaa gacttacctt                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE44g24 spacer sequence

<400>  60
aagaaaagct tgagcaagtc                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g1 spacer sequence

<400>  61
ttattcttct ttctccaggc                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g2 spacer sequence

<400>  62
aattttattc ttctttctcc                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g5 spacer sequence

<400>  63
attcttttgt tcttctagcc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g6 spacer sequence

<400>  64
aaatgaattt gttttatggt                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g7 spacer sequence

<400>  65
tgaatttgtt ttatggttgg                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g8 spacer sequence

<400>  66
agaaaagctt gagcaagtca                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g9 spacer sequence

<400>  67
ttcttctagc ctggagaaag                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g10 spacer sequence

<400>  68
caattttatt cttctttctc                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g11 spacer sequence

<400>  69
ttgttcttct agcctggaga                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g12 spacer sequence

<400>  70
tcttttgttc ttctagcctg                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g13 spacer sequence

<400>  71
ttcttctttc tccaggctag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g14 spacer sequence

<400>  72
acttgctcaa gcttttcttt                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g15 spacer sequence

<400>  73
actaaaagaa aagcttgagc                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g16 spacer sequence

<400>  74
aaaattacct tgacttgctc                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g17 spacer sequence

<400>  75
aagaaaagct tgagcaagtc                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hE46g18 spacer sequence

<400>  76
aagaaaagct tgagcaagtc                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g1 spacer sequence

<400>  77
tgaaagaatt cagattcagt                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g2 spacer sequence

<400>  78
aattcagatt cagtgggatg                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g3 spacer sequence

<400>  79
ttcaagaaca gctgcagaac                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g4 spacer sequence

<400>  80
acagttgaat gaaatgttaa                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g5 spacer sequence

<400>  81
tgttaaagga ttcaacacaa                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g6 spacer sequence

<400>  82
aaaggattca acacaatggc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g7 spacer sequence

<400>  83
aaagaagatc acagaaacca                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g8 spacer sequence

<400>  84
ttgaaagaat tcagattcag                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g9 spacer sequence

<400>  85
agtgggatga ggttcaagaa                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g10 spacer sequence

<400>  86
agctgcagaa caggagacaa                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g11 spacer sequence

<400>  87
tgaatctgaa ttctttcaac                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g12 spacer sequence

<400>  88
ctttcaactg gaataaaaat                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g13 spacer sequence

<400>  89
cttattttta ttccagttga                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g14 spacer sequence

<400>  90
ttattccagt tgaaagaatt                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g15 spacer sequence

<400>  91
cagttgaaag aattcagatt                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g16 spacer sequence

<400>  92
gaattcagat tcagtgggat                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g17 spacer sequence

<400>  93
gattcagtgg gatgaggttc                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g18 spacer sequence

<400>  94
atgaggttca agaacagctg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g19 spacer sequence

<400>  95
gttcaagaac agctgcagaa                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g20 spacer sequence

<400>  96
aactgttgtc tcctgttctg                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g21 spacer sequence

<400>  97
caagaacagc tgcagaacag                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g22 spacer sequence

<400>  98
aagatcacag aaaccaaggt                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE53g23 spacer sequence

<400>  99
cagaaaccaa ggttagtgtc                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g1 spacer sequence

<400>  100
catccatgtt ttcaaattat                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g2 spacer sequence

<400>  101
tcgacagatc agttgaaaaa                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g3 spacer sequence

<400>  102
agacacaaaa tcctgaaaac                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g4 spacer sequence

<400>  103
ttagcatgtt cccagttttc                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g5 spacer sequence

<400>  104
gacacaaaat cctgaaaact                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g6 spacer sequence

<400>  105
gggaacatgc taaatacaaa                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g7 spacer sequence

<400>  106
taaatacaaa tggtatctta                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g8 spacer sequence

<400>  107
tcatccatgt tttcaaatta                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g9 spacer sequence

<400>  108
tcaaattata ggcgattcga                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g10 spacer sequence

<400>  109
aaaaactgtt caacttcatt                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g11 spacer sequence

<400>  110
aatggctgaa tgaagttgaa                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g12 spacer sequence

<400>  111
aagttgaaca gtttttcaaa                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g13 spacer sequence

<400>  112
tttagcatgt tcccagtttt                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g14 spacer sequence

<400>  113
cttaagatac catttgtatt                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g15 spacer sequence

<400>  114
ctaaatacaa atggtatctt                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g16 spacer sequence

<400>  115
tacaaatggt atcttaaggt                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g17 spacer sequence

<400>  116
aaatctcaaa gtcttacctt                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g18 spacer sequence

<400>  117
ttataggcga ttcgacagat                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g19 spacer sequence

<400>  118
catggatgaa ataaggtaag                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g20 spacer sequence

<400>  119
ctgaaaaaat gaagccagca                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44g21 spacer sequence

<400>  120
atttaatcaa tggctgaatg                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g1 spacer sequence

<400>  121
aattttgtta ttcttaatac                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g2 spacer sequence

<400>  122
aaatgaattt gttttgtggc                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g3 spacer sequence

<400>  123
aacattgcta ttactccact                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g4 spacer sequence

<400>  124
agctgctgct catctccaag                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g5 spacer sequence

<400>  125
agaacaactt gaacaagtca                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g6 spacer sequence

<400>  126
gaattttgtt attcttaata                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g7 spacer sequence

<400>  127
ttgttcttca atcctgtatt                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g8 spacer sequence

<400>  128
ttattcttaa tacaggattg                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g9 spacer sequence

<400>  129
aatacaggat tgaagaacaa                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g10 spacer sequence

<400>  130
ttactccact tggagatgag                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g11 spacer sequence

<400>  131
gctaaaagaa caacttgaac                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g12 spacer sequence

<400>  132
gaaattacct tgacttgttc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g13 spacer sequence

<400>  133
aagaacaact tgaacaagtc                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g14 spacer sequence

<400>  134
acttgttcaa gttgttcttt                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g15 spacer sequence

<400>  135
acacctctca gggatttagg                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g16 spacer sequence

<400>  136
ttcccttatt aaaatcctca                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE46g17 spacer sequence

<400>  137
ctttatacaa ataggccctg                                                   20


<210>  138
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  138
gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgctttt ttt                                    93


<210>  139
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  139
gttttagagc tagaaatagc agttaaaata aggctagtcc gttatcaact tgaaaaagtg       60

gcaccgagtc ggtg                                                         74


<210>  140
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  140
gttggaacca ttcaaaacag catagcaagt taaaataagg ctagtccgtt atcaacttga       60

aaaagtggca ccgagtcggt gctttttt                                          88


<210>  141
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  141
gtttaagagc tatgaaacag catagcaagt ttaaataagg ctagtccgtt atcaacttga       60

aaaagtggca ccgagtcggt gcttttttt                                         89


<210>  142
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  142
gtttaagagc tatgcgaaac agcatagcaa gtttaaataa ggctagtccg ttatcaactt       60

gaaaaagtgg caccgagtcg gtgctttttt t                                      91


<210>  143
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  143
gtttaagagc tatgctgttt gaaacagcat agcaagttta aataaggcta gtccgttatc       60

aacttgaaaa agtggcaccg agtcggtgct tttttt                                 96


<210>  144
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  gRNA scaffold sequence

<400>  144
gtttaagagc tatgctgttt tggaaacagc atagcaagtt taaataaggc tagtccgtta       60

tcaacttgaa aaagtggcac cgagtcggtg cttttttt                               98


<210>  145
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  sgRNA sequence

<400>  145
aagaaaagct tgagcaagtc gtttaagagc tatgctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttt             113


<210>  146
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CK8 promoter

<400>  146
ctagactagc atgctgccca tgtaaggagg caaggcctgg ggacacccga gatgcctggt       60

tataattaac ccagacatgt ggctgccccc ccccccccaa cacctgctgc ctctaaaaat      120

aaccctgcat gccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca      180

cttagtttag gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg      240

ctgggcaagc tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag      300

ctcatctgct ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt      360

aggctcctct atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca      420

gcacagacag acactcagga gccagccagc                                       450


<210>  147
<211>  436
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  CK8e promoter

<400>  147
tgcccatgta aggaggcaag gcctggggac acccgagatg cctggttata attaacccag       60

acatgtggct gccccccccc ccccaacacc tgctgcctct aaaaataacc ctgcatgcca      120

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      180

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      240

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      300

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      360

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      420

tcaggagcca gccagc                                                      436


<210>  148
<211>  18
<212>  PRT
<213>  Thosea asigna

<400>  148

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  149
<211>  20
<212>  PRT
<213>  equine rhinitis A virus

<400>  149

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  150
<211>  19
<212>  PRT
<213>  porcine teschovirus

<400>  150

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  151
<211>  23
<212>  PRT
<213>  foot and mouth disease virus

<400>  151

Pro Val Lys Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  152
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N1-Top primer

<400>  152
caccgaagtg agttccagga cagcc                                             25


<210>  153
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N1-Bottom primer

<400>  153
aaacggctgt cctggaactc acttc                                             25


<210>  154
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N2-Top primer

<400>  154
caccgttatt agtactaact cagaa                                             25


<210>  155
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N2-Bottom primer

<400>  155
aaacttctga gttagtacta ataac                                             25


<210>  156
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N3-Top primer

<400>  156
caccgtagta ctaataaaag tagtc                                             25


<210>  157
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-N3-Bottom primer

<400>  157
aaacgactac ttttattagt actac                                             25


<210>  158
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C1-Top primer

<400>  158
caccgatgtt gaaatacact gctct                                             25


<210>  159
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C1-Bottom primer

<400>  159
aaacagagca gtgtatttca acatc                                             25


<210>  160
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C2-Top primer

<400>  160
caccggtaaa tatcaacttc taaat                                             25


<210>  161
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C2-Bottom primer

<400>  161
aaacatttag aagttgatat ttacc                                             25


<210>  162
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C3-Top primer

<400>  162
caccggtatt tccctatttt taatg                                             25


<210>  163
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-C3-Bottom primer

<400>  163
aaaccattaa aaatagggaa atacc                                             25


<210>  164
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G1-top primer

<400>  164
caccgaacta atatatccaa atact                                             25


<210>  165
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G1-bot primer

<400>  165
aaacagtatt tggatatatt agttc                                             25


<210>  166
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G2-top primer

<400>  166
caccgttaaa catagaacat ccttg                                             25


<210>  167
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G2-bot primer

<400>  167
aaaccaagga tgttctatgt ttaac                                             25


<210>  168
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G3-top primer

<400>  168
caccgaatcg aatttgctct tgaga                                             25


<210>  169
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-5-G3-bot primer

<400>  169
aaactctcaa gagcaaattc gattc                                             25


<210>  170
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G4-top primer

<400>  170
caccgagttt gtgctaaaaa tcatg                                             25


<210>  171
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G4-bot primer

<400>  171
aaaccatgat ttttagcaca aactc                                             25


<210>  172
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G5-top primer

<400>  172
caccggcttt acccagctga atcac                                             25


<210>  173
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G5-bot primer

<400>  173
aaacgtgatt cagctgggta aagcc                                             25


<210>  174
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G6-top primer

<400>  174
caccgaattt tcacagcatt gctta                                             25


<210>  175
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Exon45-3-G6-bot primer

<400>  175
aaactaagca atgctgtgaa aattc                                             25


<210>  176
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N1-Top primer

<400>  176
caccgaacta atatatccaa atact                                             25


<210>  177
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N1-bottom primer

<400>  177
aaacagtatt tggatatatt agttc                                             25


<210>  178
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N2-Top primer

<400>  178
caccgttaaa catagaacat ccttg                                             25


<210>  179
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N2-bottom primer

<400>  179
aaaccaagga tgttctatgt ttaac                                             25


<210>  180
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N3-Top primer

<400>  180
caccgaatcg aatttgctct tgaga                                             25


<210>  181
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-N3-bottom primer

<400>  181
aaactctcaa gagcaaattc gattc                                             25


<210>  182
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C1-Top primer

<400>  182
caccgagttt gtgctaaaaa tcatg                                             25


<210>  183
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C1-Bottom primer

<400>  183
aaaccatgat ttttagcaca aactc                                             25


<210>  184
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C2-Top primer

<400>  184
caccggcttt acccagctga atcac                                             25


<210>  185
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C2-Bottom primer

<400>  185
aaacgtgatt cagctgggta aagcc                                             25


<210>  186
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C3-Top primer

<400>  186
caccgaattt tcacagcatt gctta                                             25


<210>  187
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-C3-Bottom primer

<400>  187
aaactaagca atgctgtgaa aattc                                             25


<210>  188
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-geno-F1 primer

<400>  188
agatgtggta acgcacacct                                                   20


<210>  189
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex43-geno-R1 primer

<400>  189
tctgcagccg aataccttca                                                   20


<210>  190
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex45-geno-F1 primer

<400>  190
tgcaaaatag atcggtgcaa                                                   20


<210>  191
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex45-geno-R2 primer

<400>  191
tagcatgcat ttggcttcag                                                   20


<210>  192
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-geno-F1 primer

<400>  192
agggaatctg ctgtccttga                                                   20


<210>  193
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-Ex52-geno-R1 primer

<400>  193
tggaggttag atttcacaac tgt                                               23


<210>  194
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-dE43-E4146-RT-R2 primer

<400>  194
ctgctgctca tctccaagtg                                                   20


<210>  195
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-dE43-E4246-RT-F3 primer

<400>  195
agtgacgact gaagatatgc ct                                                22


<210>  196
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-E4347-RT-F2 primer

<400>  196
aggtgaaagt acaggaagcc gt                                                22


<210>  197
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-E4347-RT-R2 primer

<400>  197
cttctggcct tatgggagca ct                                                22


<210>  198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-E5054-RT-R1 primer

<400>  198
tgacggaggt ctttggccaa                                                   20


<210>  199
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-E5155-RT-F1 primer

<400>  199
ttggaggtac ctgcactggc                                                   20


<210>  200
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44-T7E1-F1 primer

<400>  200
agggagaaga tgctaattat cctaag                                            26


<210>  201
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mE44-T7E1-R1 primer

<400>  201
caaaacagtc atagcacaat tttcag                                            26


<210>  202
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-sE46-T7E1-F2 primer

<400>  202
tcttcacaag ccccctctta                                                   20


<210>  203
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-sE46-T7E1-R1 primer

<400>  203
caactggtag gcagtttgca t                                                 21


<210>  204
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-sE53-T7E1-F2 primer

<400>  204
tgcccacaag taagtgctga                                                   20


<210>  205
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  mDmd-sE53-T7E1-R1 primer

<400>  205
ttgtctcaaa accaaccaac c                                                 21


<210>  206
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE53-T7E1-F1 primer

<400>  206
gggaaatcag gctgatgggt                                                   20


<210>  207
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE53-T7E1-R1 primer

<400>  207
gtctactgtt catttcagc                                                    19


<210>  208
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE44-T7E1-F2 primer

<400>  208
gcaggaaact atcagagtg                                                    19


<210>  209
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE44-T7E1-R2 primer

<400>  209
acaccttgct gttacgat                                                     18


<210>  210
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE46-T7E1-F1 primer

<400>  210
ccaccaaacc tggcaaat                                                     18


<210>  211
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  hDMD-sE46-T7E1-R1 primer

<400>  211
gaactatgaa taacctaatg ggcag                                             25


