                         SEQUENCE LISTING

<110>  Children's Hospital & Research Center at Oakland
       THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
	Saba, Julie D.
       Zhao, Piming
 
<120>  ADENO-ASSOCIATED VIRAL (AAV)-MEDIATED SGPL1 GENE THERAPY FOR 
       TREATMENT OF SPHINGOSINE-1-PHOSPHATE LYASE INSUFFICIENCY SYNDROME
        (SPLIS)

<130>  CHOR-084WO

<150>  US 62/979,252
<151>  2020-02-20

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Thr Asp Leu Leu Met Leu Lys Ala Phe Glu Pro Tyr Leu 
1               5                   10                  15      


Glu Ile Leu Glu Val Tyr Ser Thr Lys Ala Lys Asn Tyr Val Asn Gly 
            20                  25                  30          


His Cys Thr Lys Tyr Glu Pro Trp Gln Leu Ile Ala Trp Ser Val Val 
        35                  40                  45              


Trp Thr Leu Leu Ile Val Trp Gly Tyr Glu Phe Val Phe Gln Pro Glu 
    50                  55                  60                  


Ser Leu Trp Ser Arg Phe Lys Lys Lys Cys Phe Lys Leu Thr Arg Lys 
65                  70                  75                  80  


Met Pro Ile Ile Gly Arg Lys Ile Gln Asp Lys Leu Asn Lys Thr Lys 
                85                  90                  95      


Asp Asp Ile Ser Lys Asn Met Ser Phe Leu Lys Val Asp Lys Glu Tyr 
            100                 105                 110         


Val Lys Ala Leu Pro Ser Gln Gly Leu Ser Ser Ser Ala Val Leu Glu 
        115                 120                 125             


Lys Leu Lys Glu Tyr Ser Ser Met Asp Ala Phe Trp Gln Glu Gly Arg 
    130                 135                 140                 


Ala Ser Gly Thr Val Tyr Ser Gly Glu Glu Lys Leu Thr Glu Leu Leu 
145                 150                 155                 160 


Val Lys Ala Tyr Gly Asp Phe Ala Trp Ser Asn Pro Leu His Pro Asp 
                165                 170                 175     


Ile Phe Pro Gly Leu Arg Lys Ile Glu Ala Glu Ile Val Arg Ile Ala 
            180                 185                 190         


Cys Ser Leu Phe Asn Gly Gly Pro Asp Ser Cys Gly Cys Val Thr Ser 
        195                 200                 205             


Gly Gly Thr Glu Ser Ile Leu Met Ala Cys Lys Ala Tyr Arg Asp Leu 
    210                 215                 220                 


Ala Phe Glu Lys Gly Ile Lys Thr Pro Glu Ile Val Ala Pro Gln Ser 
225                 230                 235                 240 


Ala His Ala Ala Phe Asn Lys Ala Ala Ser Tyr Phe Gly Met Lys Ile 
                245                 250                 255     


Val Arg Val Pro Leu Thr Lys Met Met Glu Val Asp Val Arg Ala Met 
            260                 265                 270         


Arg Arg Ala Ile Ser Arg Asn Thr Ala Met Leu Val Cys Ser Thr Pro 
        275                 280                 285             


Gln Phe Pro His Gly Val Ile Asp Pro Val Pro Glu Val Ala Lys Leu 
    290                 295                 300                 


Ala Val Lys Tyr Lys Ile Pro Leu His Val Asp Ala Cys Leu Gly Gly 
305                 310                 315                 320 


Phe Leu Ile Val Phe Met Glu Lys Ala Gly Tyr Pro Leu Glu His Pro 
                325                 330                 335     


Phe Asp Phe Arg Val Lys Gly Val Thr Ser Ile Ser Ala Asp Thr His 
            340                 345                 350         


Lys Tyr Gly Tyr Ala Pro Lys Gly Ser Ser Leu Val Leu Tyr Ser Asp 
        355                 360                 365             


Lys Lys Tyr Arg Asn Tyr Gln Phe Phe Val Asp Thr Asp Trp Gln Gly 
    370                 375                 380                 


Gly Ile Tyr Ala Ser Pro Thr Ile Ala Gly Ser Arg Pro Gly Gly Ile 
385                 390                 395                 400 


Ser Ala Ala Cys Trp Ala Ala Leu Met His Phe Gly Glu Asn Gly Tyr 
                405                 410                 415     


Val Glu Ala Thr Lys Gln Ile Ile Lys Thr Ala Arg Phe Leu Lys Ser 
            420                 425                 430         


Glu Leu Glu Asn Ile Lys Gly Ile Phe Val Phe Gly Asn Pro Gln Leu 
        435                 440                 445             


Ser Val Ile Ala Leu Gly Ser Arg Asp Phe Asp Ile Tyr Arg Leu Ser 
    450                 455                 460                 


Asn Leu Met Thr Ala Lys Gly Trp Asn Leu Asn Gln Leu Gln Phe Pro 
465                 470                 475                 480 


Pro Ser Ile His Phe Cys Ile Thr Leu Leu His Ala Arg Lys Arg Val 
                485                 490                 495     


Ala Ile Gln Phe Leu Lys Asp Ile Arg Glu Ser Val Thr Gln Ile Met 
            500                 505                 510         


Lys Asn Pro Lys Ala Lys Thr Thr Gly Met Gly Ala Ile Tyr Gly Met 
        515                 520                 525             


Ala Gln Thr Thr Val Asp Arg Asn Met Val Ala Glu Leu Ser Ser Val 
    530                 535                 540                 


Phe Leu Asp Ser Leu Tyr Ser Thr Asp Thr Val Thr Gln Gly Ser Gln 
545                 550                 555                 560 


Met Asn Gly Ser Pro Lys Pro His 
                565             


<210>  2
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcctagca cagaccttct gatgttgaag gcctttgagc cctacttaga gattttggaa       60

gtatactcca caaaagccaa gaattatgta aatggacatt gcaccaagta tgagccctgg      120

cagctaattg catggagtgt cgtgtggacc ctgctgatag tctggggata tgagtttgtc      180

ttccagccag agagtttatg gtcaaggttt aaaaagaaat gttttaagct caccaggaag      240

atgcccatta ttggtcgtaa gattcaagac aagttgaaca agaccaagga tgatattagc      300

aagaacatgt cattcctgaa agtggacaaa gagtatgtga aagctttacc ctcccagggt      360

ctgagctcat ctgctgtttt ggagaaactt aaggagtaca gctctatgga cgccttctgg      420

caagagggga gagcctctgg aacagtgtac agtggggagg agaagctcac tgagctcctt      480

gtgaaggctt atggagattt tgcatggagt aaccccctgc atccagatat cttcccagga      540

ctacgcaaga tagaggcaga aattgtgagg atagcttgtt ccctgttcaa tgggggacca      600

gattcgtgtg gatgtgtgac ttctggggga acagaaagca tactgatggc ctgcaaagca      660

tatcgggatc tggcctttga gaaggggatc aaaactccag aaattgtggc tccccaaagt      720

gcccatgctg catttaacaa agcagccagt tactttggga tgaagattgt gcgggtccca      780

ttgacgaaga tgatggaggt ggatgtgcgg gcaatgagaa gagctatctc caggaacact      840

gccatgctcg tctgttctac cccacagttt cctcatggtg taatagatcc tgtccctgaa      900

gtggccaagc tggctgtcaa atacaaaata ccccttcatg tcgacgcttg tctgggaggc      960

ttcctcatcg tctttatgga gaaagcagga tacccactgg agcacccatt tgatttccgg     1020

gtgaaaggtg taaccagcat ttcagctgac acccataagt atggctatgc cccaaaaggc     1080

tcatcattgg tgttgtatag tgacaagaag tacaggaact atcagttctt cgtcgataca     1140

gattggcagg gtggcatcta tgcttcccca accatcgcag gctcacggcc tggtggcatt     1200

agcgcagcct gttgggctgc cttgatgcac ttcggtgaga acggctatgt tgaagctacc     1260

aaacagatca tcaaaactgc tcgcttcctc aagtcagaac tggaaaatat caaaggcatc     1320

tttgtttttg ggaatcccca attgtcagtc attgctctgg gatcccgtga ttttgacatc     1380

taccgactat caaacctgat gactgctaag gggtggaact tgaaccagtt gcagttccca     1440

cccagtattc atttctgcat cacattacta cacgcccgga aacgagtagc tatacaattc     1500

ctaaaggaca ttcgagaatc tgtcactcaa atcatgaaga atcctaaagc gaagaccaca     1560

ggaatgggtg ccatctatgg catggcccag acaactgttg acaggaatat ggttgcagaa     1620

ttgtcctcag tcttcttgga cagcttgtac agcaccgaca ctgtcaccca gggcagccag     1680

atgaatggtt ctccaaaacc acac                                            1704


<210>  3
<211>  2101
<212>  DNA
<213>  Homo sapiens

<400>  3
acacacacac acagggcttc atcggctcag agagttgcaa acccagaccc atgttctagg       60

ctgggctctg ccaggaactg ctaggagtcg catctctctc tggacctcag tttcttcacg      120

tgtatttgtg tattctctgg ggtggagctg gcgaatagct ggagacccct ctagccctac      180

cattttttga ttctaattaa ccaaaaagga tattcgaggt ccccgctaca aattctgaac      240

ccttggcttc ccctccaaac tcccacacaa actccacccc atcctgcctg tgtgtctttg      300

ggaggatcat ttccttcttt ggtcttggtg tccttgttta caggttgagg gatgataaga      360

gtcacctgat ctgggcaagt caggccataa ataaggcttg tatgtaaagg tgcctagcat      420

agttcttggc aaagcaagga tcagtcgata tgattgcatt ggtttgagca tctgggaaga      480

atgagcagac tgcatactgt gtgttagggt gtagggagga atcagacgtg accctgccct      540

ctagtcatct gggtgcacag attctagatt aaaggatgtg ggggtggtaa ctaacaagga      600

gatggagagg aggtgtgcag ttcctggggg atctgatgaa gaattaaagc agaagggtag      660

gagatggaga atgggaaggc atacctgaaa ccctaaagca actcttgatg agtaggcatt      720

ggcaggaggc cccagaacat tttctgaccc tcaaacactg agaatgcatg tctgctgggg      780

aatagtagtg agggggctaa gggtatgggg gtgttcatgc ctgagtcagg ggctctggat      840

ggtagaaatg tctgggagtt ctgacggaat gggggtgagg aggcctaaag ataacctgtt      900

catagtcttt cagggcctta accattatgg ctggggaagt gggaagtgcc gatggggtat      960

gcagaggagg gcagctgtga tagtacattt catcctgaaa gcactacatg tggataatga     1020

cggtagtgat gatgccctaa ttttagtgtc atggcaacat tttccaaggg gatggaattg     1080

ggtaccctca ttagtgtcat ttttgtttga gagatttcaa gagtctatct aggtgtcatt     1140

ttaaaatcta ttgaaaaaaa atcttgaatg caggtcactg accagttggt tccatgtaac     1200

tgcactgcct tctgctacca ctaaagcaat gttatgacaa cctggacaag tcatgggaaa     1260

cctatgtgag acttagtttt ttctttttct ttttggagtt gggggtctca ctatgttgct     1320

caggctgatc tagagctcct gggctcagac aaccctcccg cctcagcatc cccaagtgcc     1380

gggattaccg atgtaagcca ctacacccag ctgagactta gttttttcat ctggaaatga     1440

aggcgacctt tgtgatccca gtgggccctt gcacttgtgt ataaggtgat tcccagcact     1500

gctcatgaaa gtagtgatgg cagagtagcc tctgctctcc attttatttt tggggtgggg     1560

gggggcagtg gtggagggga ggatgaggat gatatttcca ttaaataagt ttccttgttg     1620

cttttcttca ggcaccactg acctcgatgg aaaaatgaag tccctggccc aggaaagaga     1680

cccaactctg tggctgtttt ggattagttt gtacaatgcc ctgcagacct actctctcag     1740

gaggctccaa gtgaccaaat gtgacaagaa agttttttgt ccaaggcagt ttggaagaga     1800

agttggtgac cgtcgggata ccacagccgc cccaggacgg cctggttgag acattcactg     1860

gagggtctgg gtgcagcccg ctgcctggcc ggtaggcggc gcgcacaggc cgtggggccc     1920

gggtctgggc gtgcgcgcgg ctggtagcag cggggccgcg cacgccaggg tccgggagcc     1980

gggccggtgc ccccggagcc atttccggga ggggcgaggc cggcggctgc cgggcctcca     2040

atctcggcgg cggcggcggc aacaggggag cctgggtctc gcggcctgcg agtccgtcgc     2100

g                                                                     2101


<210>  4
<211>  7077
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtggagc tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgtcaata gggactttcc attgacgtca atgggtggag tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc      540

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca      600

ttgacgtcaa tgggagtttg ttttgcacca aaatcaacgg gactttccaa aatgtcgtaa      660

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      720

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      780

ccatagaaga caccgggacc gatccagcct ccgcggattc gaatcccggc cgggaacggt      840

gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat agagtctata      900

ggcccacaaa aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac      960

tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc     1020

attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata     1080

aatatttctg catataaatt gtaactgatg taagaggttt catattgcta atagcagcta     1140

caatccagct accattctgc ttttatttta tggttgggat aaggctggat tattctgagt     1200

ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg     1260

ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattggg attcgaacat     1320

cgattgaatt cgccaccatg cctagcacag accttctgat gttgaaggcc tttgagccct     1380

acttagagat tttggaagta tactccacaa aagccaagaa ttatgtaaat ggacattgca     1440

ccaagtatga gccctggcag ctaattgcat ggagtgtcgt gtggaccctg ctgatagtct     1500

ggggatatga gtttgtcttc cagccagaga gtttatggtc aaggtttaaa aagaaatgtt     1560

ttaagctcac caggaagatg cccattattg gtcgtaagat tcaagacaag ttgaacaaga     1620

ccaaggatga tattagcaag aacatgtcat tcctgaaagt ggacaaagag tatgtgaaag     1680

ctttaccctc ccagggtctg agctcatctg ctgttttgga gaaacttaag gagtacagct     1740

ctatggacgc cttctggcaa gaggggagag cctctggaac agtgtacagt ggggaggaga     1800

agctcactga gctccttgtg aaggcttatg gagattttgc atggagtaac cccctgcatc     1860

cagatatctt cccaggacta cgcaagatag aggcagaaat tgtgaggata gcttgttccc     1920

tgttcaatgg gggaccagat tcgtgtggat gtgtgacttc tgggggaaca gaaagcatac     1980

tgatggcctg caaagcatat cgggatctgg cctttgagaa ggggatcaaa actccagaaa     2040

ttgtggctcc ccaaagtgcc catgctgcat ttaacaaagc agccagttac tttgggatga     2100

agattgtgcg ggtcccattg acgaagatga tggaggtgga tgtgcgggca atgagaagag     2160

ctatctccag gaacactgcc atgctcgtct gttctacccc acagtttcct catggtgtaa     2220

tagatcctgt ccctgaagtg gccaagctgg ctgtcaaata caaaataccc cttcatgtcg     2280

acgcttgtct gggaggcttc ctcatcgtct ttatggagaa agcaggatac ccactggagc     2340

acccatttga tttccgggtg aaaggtgtaa ccagcatttc agctgacacc cataagtatg     2400

gctatgcccc aaaaggctca tcattggtgt tgtatagtga caagaagtac aggaactatc     2460

agttcttcgt cgatacagat tggcagggtg gcatctatgc ttccccaacc atcgcaggct     2520

cacggcctgg tggcattagc gcagcctgtt gggctgcctt gatgcacttc ggtgagaacg     2580

gctatgttga agctaccaaa cagatcatca aaactgctcg cttcctcaag tcagaactgg     2640

aaaatatcaa aggcatcttt gtttttggga atccccaatt gtcagtcatt gctctgggat     2700

cccgtgattt tgacatctac cgactatcaa acctgatgac tgctaagggg tggaacttga     2760

accagttgca gttcccaccc agtattcatt tctgcatcac attactacac gcccggaaac     2820

gagtagctat acaattccta aaggacattc gagaatctgt cactcaaatc atgaagaatc     2880

ctaaagcgaa gaccacagga atgggtgcca tctatggcat ggcccagaca actgttgaca     2940

ggaatatggt tgcagaattg tcctcagtct tcttggacag cttgtacagc accgacactg     3000

tcacccaggg cagccagatg aatggttctc caaaaccaca cgagggcaga ggaagtcttc     3060

taacatgcgg tgacgtggag gagaatcccg gccctatggt gtctaagggc gaagagctga     3120

ttaaggagaa catgcacatg aagctgtaca tggagggcac cgtgaacaac caccacttca     3180

agtgcacatc cgagggcgaa ggcaagccct acgagggcac ccagaccatg agaatcaagg     3240

tggtcgaggg cggccctctc cccttcgcct tcgacatcct ggctaccagc ttcatgtacg     3300

gcagcagaac cttcatcaac cacacccagg gcatccccga cttctttaag cagtccttcc     3360

ctgagggctt cacatgggag agagtcacca catacgaaga cgggggcgtg ctgaccgcta     3420

cccaggacac cagcctccag gacggctgcc tcatctacaa cgtcaagatc agaggggtga     3480

acttcccatc caacggccct gtgatgcaga agaaaacact cggctgggag gccaacaccg     3540

agatgctgta ccccgctgac ggcggcctgg aaggcagaag cgacatggcc ctgaagctcg     3600

tgggcggggg ccacctgatc tgcaacttca agaccacata cagatccaag aaacccgcta     3660

agaacctcaa gatgcccggc gtctactatg tggaccacag actggaaaga atcaaggagg     3720

ccgacaaaga gacctacgtc gagcagcacg aggtggctgt ggccagatac tgcgacctcc     3780

ctagcaaact ggggcacaaa cttaattgac tcgagagatc tacgggtggc atccctgtga     3840

cccctcccca gtgcctctcc tggccctgga agttgccact ccagtgccca ccagccttgt     3900

cctaataaaa ttaagttgca tcattttgtc tgactaggtg tccttctata atattatggg     3960

gtggaggggg gtggtatgga gcaaggggca agttgggaag acaacctgta gggcctgcgg     4020

ggtctattgg gaaccaagct ggagtgcagt ggcacaatct tggctcactg caatctccgc     4080

ctcctgggtt caagcgattc tcctgcctca gcctcccgag ttgttgggat tccaggcatg     4140

catgaccagg ctcagctaat ttttgttttt ttggtagaga cggggtttca ccatattggc     4200

caggctggtc tccaactcct aatctcaggt gatctaccca ccttggcctc ccaaattgct     4260

gggattacag gcgtgaacca ctgctccctt ccctgtcctt ctgattttgt aggtaaccac     4320

gtgcggaccg agcggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc     4380

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     4440

gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt     4500

ctccttacgc atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc     4560

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     4620

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     4680

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     4740

tacggcacct cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc     4800

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     4860

tgttccaaac tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga     4920

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     4980

attttaacaa aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg     5040

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     5100

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     5160

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     5220

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     5280

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     5340

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     5400

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     5460

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     5520

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     5580

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     5640

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     5700

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     5760

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     5820

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     5880

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     5940

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6000

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6060

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6120

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6180

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6240

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6300

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6360

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6420

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6480

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     6540

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     6600

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     6660

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     6720

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     6780

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     6840

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6900

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6960

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7020

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgt        7077


<210>  5
<211>  6312
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtggagc tagttattaa tagtaatcaa      180

ttacggggtc attagttcat agcccatata tggagttccg cgttacataa cttacggtaa      240

atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg      300

ttcccatagt aacgtcaata gggactttcc attgacgtca atgggtggag tatttacggt      360

aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg      420

tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc      480

ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc      540

agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca      600

ttgacgtcaa tgggagtttg ttttgcacca aaatcaacgg gactttccaa aatgtcgtaa      660

caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag      720

cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct      780

ccatagaaga caccgggacc gatccagcct ccgcggattc gaatcccggc cgggaacggt      840

gcattggaac gcggattccc cgtgccaaga gtgacgtaag taccgcctat agagtctata      900

ggcccacaaa aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac      960

tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc tctttgcacc     1020

attctaaaga ataacagtga taatttctgg gttaaggcaa tagcaatatt tctgcatata     1080

aatatttctg catataaatt gtaactgatg taagaggttt catattgcta atagcagcta     1140

caatccagct accattctgc ttttatttta tggttgggat aaggctggat tattctgagt     1200

ccaagctagg cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg     1260

ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattggg attcgaacat     1320

cgattgaatt cgccaccatg cctagcacag accttctgat gttgaaggcc tttgagccct     1380

acttagagat tttggaagta tactccacaa aagccaagaa ttatgtaaat ggacattgca     1440

ccaagtatga gccctggcag ctaattgcat ggagtgtcgt gtggaccctg ctgatagtct     1500

ggggatatga gtttgtcttc cagccagaga gtttatggtc aaggtttaaa aagaaatgtt     1560

ttaagctcac caggaagatg cccattattg gtcgtaagat tcaagacaag ttgaacaaga     1620

ccaaggatga tattagcaag aacatgtcat tcctgaaagt ggacaaagag tatgtgaaag     1680

ctttaccctc ccagggtctg agctcatctg ctgttttgga gaaacttaag gagtacagct     1740

ctatggacgc cttctggcaa gaggggagag cctctggaac agtgtacagt ggggaggaga     1800

agctcactga gctccttgtg aaggcttatg gagattttgc atggagtaac cccctgcatc     1860

cagatatctt cccaggacta cgcaagatag aggcagaaat tgtgaggata gcttgttccc     1920

tgttcaatgg gggaccagat tcgtgtggat gtgtgacttc tgggggaaca gaaagcatac     1980

tgatggcctg caaagcatat cgggatctgg cctttgagaa ggggatcaaa actccagaaa     2040

ttgtggctcc ccaaagtgcc catgctgcat ttaacaaagc agccagttac tttgggatga     2100

agattgtgcg ggtcccattg acgaagatga tggaggtgga tgtgcgggca atgagaagag     2160

ctatctccag gaacactgcc atgctcgtct gttctacccc acagtttcct catggtgtaa     2220

tagatcctgt ccctgaagtg gccaagctgg ctgtcaaata caaaataccc cttcatgtcg     2280

acgcttgtct gggaggcttc ctcatcgtct ttatggagaa agcaggatac ccactggagc     2340

acccatttga tttccgggtg aaaggtgtaa ccagcatttc agctgacacc cataagtatg     2400

gctatgcccc aaaaggctca tcattggtgt tgtatagtga caagaagtac aggaactatc     2460

agttcttcgt cgatacagat tggcagggtg gcatctatgc ttccccaacc atcgcaggct     2520

cacggcctgg tggcattagc gcagcctgtt gggctgcctt gatgcacttc ggtgagaacg     2580

gctatgttga agctaccaaa cagatcatca aaactgctcg cttcctcaag tcagaactgg     2640

aaaatatcaa aggcatcttt gtttttggga atccccaatt gtcagtcatt gctctgggat     2700

cccgtgattt tgacatctac cgactatcaa acctgatgac tgctaagggg tggaacttga     2760

accagttgca gttcccaccc agtattcatt tctgcatcac attactacac gcccggaaac     2820

gagtagctat acaattccta aaggacattc gagaatctgt cactcaaatc atgaagaatc     2880

ctaaagcgaa gaccacagga atgggtgcca tctatggcat ggcccagaca actgttgaca     2940

ggaatatggt tgcagaattg tcctcagtct tcttggacag cttgtacagc accgacactg     3000

tcacccaggg cagccagatg aatggttctc caaaacccca ctgactcgag agatctacgg     3060

gtggcatccc tgtgacccct ccccagtgcc tctcctggcc ctggaagttg ccactccagt     3120

gcccaccagc cttgtcctaa taaaattaag ttgcatcatt ttgtctgact aggtgtcctt     3180

ctataatatt atggggtgga ggggggtggt atggagcaag gggcaagttg ggaagacaac     3240

ctgtagggcc tgcggggtct attgggaacc aagctggagt gcagtggcac aatcttggct     3300

cactgcaatc tccgcctcct gggttcaagc gattctcctg cctcagcctc ccgagttgtt     3360

gggattccag gcatgcatga ccaggctcag ctaatttttg tttttttggt agagacgggg     3420

tttcaccata ttggccaggc tggtctccaa ctcctaatct caggtgatct acccaccttg     3480

gcctcccaaa ttgctgggat tacaggcgtg aaccactgct cccttccctg tccttctgat     3540

tttgtaggta accacgtgcg gaccgagcgg ccgcaggaac ccctagtgat ggagttggcc     3600

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     3660

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc     3720

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat acgtcaaagc     3780

aaccatagta cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca     3840

gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct     3900

ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt     3960

tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgatttgggt gatggttcac     4020

gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct     4080

ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg ggctattctt     4140

ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac     4200

aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aattttatgg tgcactctca     4260

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     4320

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     4380

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     4440

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     4500

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     4560

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     4620

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     4680

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     4740

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     4800

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     4860

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     4920

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     4980

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     5040

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     5100

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     5160

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     5220

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     5280

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     5340

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     5400

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     5460

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     5520

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     5580

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     5640

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     5700

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     5760

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     5820

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     5880

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     5940

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     6000

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     6060

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     6120

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     6180

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     6240

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     6300

ttgctcacat gt                                                         6312


<210>  6
<211>  6435
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg taccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg      240

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat      300

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc      360

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta      420

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc      480

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      540

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg      600

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt      660

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg      720

ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      780

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      840

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      900

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggctgtccgc      960

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1020

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1080

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg gatccggtac     1140

cgccaccatg gcgagcacag accttctgat gttgaaggcc tttgagccct acttagagat     1200

tttggaagta tactccacaa aagccaagaa ttatgtaaat ggacattgca ccaagtatga     1260

gccctggcag ctaattgcat ggagtgtcgt gtggaccctg ctgatagtct ggggatatga     1320

gtttgtcttc cagccagaga gtttatggtc aaggtttaaa aagaaatgtt ttaagctcac     1380

caggaagatg cccattattg gtcgtaagat tcaagacaag ttgaacaaga ccaaggatga     1440

tattagcaag aacatgtcat tcctgaaagt ggacaaagag tatgtgaaag ctttaccctc     1500

ccagggtctg agctcatctg ctgttttgga gaaacttaag gagtacagct ctatggacgc     1560

cttctggcaa gaggggagag cctctggaac agtgtacagt ggggaggaga agctcactga     1620

gctccttgtg aaggcttatg gagattttgc atggagtaac cccctgcatc cagatatctt     1680

cccaggacta cgcaagatag aggcagaaat cgtgaggata gcttgttccc tgttcaatgg     1740

gggaccagat tcgtgtggat gtgtgacttc tgggggaaca gaaagcatac tgatggcctg     1800

caaagcatat cgggatctgg cctttgagaa ggggatcaaa actccagaaa ttgtggctcc     1860

ccaaagtgcc catgctgcat ttaacaaagc agccagttac tttgggatga agattgtgcg     1920

ggtcccattg acgaagatga tggaggtgga tgtgcgggca atgagaagag ctatctccag     1980

gaacactgcc atgctcgtct gttctacccc acagtttcct catggtgtaa tagatcctgt     2040

ccctgaagtg gccaagctgg ctgtcaaata caaaataccc cttcatgtcg acgcttgtct     2100

gggaggcttc ctcatcgtct ttatggagaa agcaggatac ccactggagc acccatttga     2160

tttccgggtg aaaggtgtaa ccagcatttc agctgacacc cataagtatg gctatgcccc     2220

aaaaggctca tcattggtgt tgtatagtga caagaagtac aggaactatc agttcttcgt     2280

cgatacagat tggcagggtg gcatctatgc ttccccaacc atcgcaggct cacggcctgg     2340

tggcattagc gcagcctgtt gggctgcctt gatgcacttc ggtgagaacg gctatgttga     2400

agctaccaaa cagatcatca aaactgctcg cttcctcaag tcagaactgg aaaatatcaa     2460

aggcatcttt gtttttggga atccccaatt gtcagtcatt gctctgggat cccgtgattt     2520

tgacatctac cgactatcaa acctgatgac tgctaagggg tggaacttga accagttgca     2580

gttcccaccc agtattcatt tctgcatcac attactacac gcccggaaac gagtagctat     2640

acaattccta aaggacattc gagaatctgt cactcaaatc atgaagaatc ctaaagcgaa     2700

gaccacagga atgggtgcca tctatggcat ggcccagaca actgttgaca ggaatatggt     2760

tgcagaattg tcctcagtct tcttggacag cttgtacagc accgacactg tcacccaggg     2820

cagccagatg aatggttctc caaaacccca ctgagaattc gatatcaagc ttatcgataa     2880

tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc     2940

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat     3000

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg     3060

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg     3120

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat     3180

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt     3240

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc     3300

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa     3360

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg     3420

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg     3480

acccgggcgg ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac     3540

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     3600

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     3660

tcaggttcag ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     3720

taaaatcgat aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa     3780

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3840

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3900

cagtgagcga gcgagcgcgc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg     3960

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     4020

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     4080

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     4140

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     4200

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     4260

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     4320

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     4380

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     4440

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     4500

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     4560

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     4620

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     4680

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     4740

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     4800

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     4860

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     4920

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     4980

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     5040

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     5100

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     5160

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     5220

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     5280

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     5340

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     5400

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     5460

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     5520

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     5580

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     5640

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     5700

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     5760

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     5820

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     5880

gcgcacattt ccccgaaaag tgccacctaa attgtaagcg ttaatatttt gttaaaattc     5940

gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat cggcaaaatc     6000

ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt ttggaacaag     6060

agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt ctatcagggc     6120

gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag gtgccgtaaa     6180

gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg aaagccggcg     6240

aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc gctggcaagt     6300

gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc gctacagggc     6360

gcgtcccatt cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct     6420

tcgctattac gccag                                                      6435


<210>  7
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7
cgctcagaag gctctgagtc atgg                                              24


<210>  8
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8
ccaagtgtac ctgctaagtt ccag                                              24


<210>  9
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9
catcaaggaa accctggact actg                                              24


