SEQUENCE LISTING

<110>   TRANSLATE BIO INC.

<120>   IMPROVED PROCESSES FOR IN VITRO TRANSCRIPTION OF MESSENGER RNA

<130>   MRT-2121 USP1

<140>  US 62/978,180
<141>  2020-02-18

<160>   35

<170>   SeqWin2010, version 1.0

<210>   1
<211>   8
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<222>   (1)
<223>   n is a, c, g, or t

<220>
<221>   misc_feature
<222>   (6)
<223>   n is a, c, g, or t

<220>
<221>   misc_feature
<222>   8
<223>   n is a, c, g, or t

<400>   1
natctntn                                                           8

<210>   2
<211>   8
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<222>   (1)
<223>   n is a, c, t or g

<400>   2
natctgtt                                                           8

<210>   3
<211>   16
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   3
ttttatctgt tttttt                                                  16

<210>   4
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   4
ttttatctgt tttttttt                                                18

<210>   5
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   5
cgttttatct gttttttt                                                18

<210>   6
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   6
cgttccatct gttttttt                                                18

<210>   7
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   7
cgttttatct gtttgttt                                                18

<210>   8
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   8
cgttttatct gtttgttt                                                18

<210>   9
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   9
cgttttatct gttgtttt                                                18

<210>   10
<211>   17
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<222>   (1)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (6)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (8)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (9)
<223>   n represents up to 10 nucleotides, independently selected from a, c, g and  t

<220>
<221>   misc_feature
<222>   (10)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (15)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (17)
<223>   n is a, c, g or t

<400>   10
natctntnnn atctntn                                                 17

<210>   11
<211>   26
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<222>   (1)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (6)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (8)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (9)
<223>   n represents up to 10 nucleotides, independently selected from a, c, g and  t

<220>
<221>   misc_feature
<222>   (10)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (15)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (17)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (18)
<223>   n represents up to 10 nucleotides, independently selected from a, c, g and  t

<220>
<221>   misc_feature
<222>   (19)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (24)
<223>   n is a, c, g or t

<220>
<221>   misc_feature
<222>   (26)
<223>   n is a, c, g or t

<400>   11
natctntnnn atctntnnna tctntn                                       26

<210>   12
<211>   36
<212>   DNA
<213>   Synthetic oligonucleotide

<400>   12
ttttatctgt tttttttttt ttatctgttt tttttt                            36

<210>   13
<211>   54
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   13
ttttatctgt tttttttttt ttatctgttt tttttttttt atctgttttt tttt        54

<210>   14
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   14
ttttatctgt ttttttttt                                               19

<210>   15
<211>   874
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Bateriophase SP6

<400>   15
Met Gln Asp Leu His Ala Ile Gln Leu Gln Leu Glu Glu Glu Met Phe 
1               5                   10                  15      

Asn Gly Gly Ile Arg Arg Phe Glu Ala Asp Gln Gln Arg Gln Ile Ala 
            20                  25                  30          

Ala Gly Ser Glu Ser Asp Thr Ala Trp Asn Arg Arg Leu Leu Ser Glu 
        35                  40                  45              

Leu Ile Ala Pro Met Ala Glu Gly Ile Gln Ala Tyr Lys Glu Glu Tyr 
    50                  55                  60                  

Glu Gly Lys Lys Gly Arg Ala Pro Arg Ala Leu Ala Phe Leu Gln Cys 
65                  70                  75                  80  

Val Glu Asn Glu Val Ala Ala Tyr Ile Thr Met Lys Val Val Met Asp 
                85                  90                  95      

Met Leu Asn Thr Asp Ala Thr Leu Gln Ala Ile Ala Met Ser Val Ala 
            100                 105                 110         

Glu Arg Ile Glu Asp Gln Val Arg Phe Ser Lys Leu Glu Gly His Ala 
        115                 120                 125             

Ala Lys Tyr Phe Glu Lys Val Lys Lys Ser Leu Lys Ala Ser Arg Thr 
    130                 135                 140                 

Lys Ser Tyr Arg His Ala His Asn Val Ala Val Val Ala Glu Lys Ser 
145                 150                 155                 160 

Val Ala Glu Lys Asp Ala Asp Phe Asp Arg Trp Glu Ala Trp Pro Lys 
                165                 170                 175     

Glu Thr Gln Leu Gln Ile Gly Thr Thr Leu Leu Glu Ile Leu Glu Gly 
            180                 185                 190         

Ser Val Phe Tyr Asn Gly Glu Pro Val Phe Met Arg Ala Met Arg Thr 
        195                 200                 205             

Tyr Gly Gly Lys Thr Ile Tyr Tyr Leu Gln Thr Ser Glu Ser Val Gly 
    210                 215                 220                 

Gln Trp Ile Ser Ala Phe Lys Glu His Val Ala Gln Leu Ser Pro Ala 
225                 230                 235                 240 

Tyr Ala Pro Cys Val Ile Pro Pro Arg Pro Trp Arg Thr Pro Phe Asn 
                245                 250                 255     

Gly Gly Phe His Thr Glu Lys Val Ala Ser Arg Ile Arg Leu Val Lys 
            260                 265                 270         

Gly Asn Arg Glu His Val Arg Lys Leu Thr Gln Lys Gln Met Pro Lys 
        275                 280                 285             

Val Tyr Lys Ala Ile Asn Ala Leu Gln Asn Thr Gln Trp Gln Ile Asn 
    290                 295                 300                 

Lys Asp Val Leu Ala Val Ile Glu Glu Val Ile Arg Leu Asp Leu Gly 
305                 310                 315                 320 

Tyr Gly Val Pro Ser Phe Lys Pro Leu Ile Asp Lys Glu Asn Lys Pro 
                325                 330                 335     

Ala Asn Pro Val Pro Val Glu Phe Gln His Leu Arg Gly Arg Glu Leu 
            340                 345                 350         

Lys Glu Met Leu Ser Pro Glu Gln Trp Gln Gln Phe Ile Asn Trp Lys 
        355                 360                 365             

Gly Glu Cys Ala Arg Leu Tyr Thr Ala Glu Thr Lys Arg Gly Ser Lys 
    370                 375                 380                 

Ser Ala Ala Val Val Arg Met Val Gly Gln Ala Arg Lys Tyr Ser Ala 
385                 390                 395                 400 

Phe Glu Ser Ile Tyr Phe Val Tyr Ala Met Asp Ser Arg Ser Arg Val 
                405                 410                 415     

Tyr Val Gln Ser Ser Thr Leu Ser Pro Gln Ser Asn Asp Leu Gly Lys 
            420                 425                 430         

Ala Leu Leu Arg Phe Thr Glu Gly Arg Pro Val Asn Gly Val Glu Ala 
        435                 440                 445             

Leu Lys Trp Phe Cys Ile Asn Gly Ala Asn Leu Trp Gly Trp Asp Lys 
    450                 455                 460                 

Lys Thr Phe Asp Val Arg Val Ser Asn Val Leu Asp Glu Glu Phe Gln 
465                 470                 475                 480 

Asp Met Cys Arg Asp Ile Ala Ala Asp Pro Leu Thr Phe Thr Gln Trp 
                485                 490                 495     

Ala Lys Ala Asp Ala Pro Tyr Glu Phe Leu Ala Trp Cys Phe Glu Tyr 
            500                 505                 510         

Ala Gln Tyr Leu Asp Leu Val Asp Glu Gly Arg Ala Asp Glu Phe Arg 
        515                 520                 525             

Thr His Leu Pro Val His Gln Asp Gly Ser Cys Ser Gly Ile Gln His 
    530                 535                 540                 

Tyr Ser Ala Met Leu Arg Asp Glu Val Gly Ala Lys Ala Val Asn Leu 
545                 550                 555                 560 

Lys Pro Ser Asp Ala Pro Gln Asp Ile Tyr Gly Ala Val Ala Gln Val 
                565                 570                 575     

Val Ile Lys Lys Asn Ala Leu Tyr Met Asp Ala Asp Asp Ala Thr Thr 
            580                 585                 590         

Phe Thr Ser Gly Ser Val Thr Leu Ser Gly Thr Glu Leu Arg Ala Met 
        595                 600                 605             

Ala Ser Ala Trp Asp Ser Ile Gly Ile Thr Arg Ser Leu Thr Lys Lys 
    610                 615                 620                 

Pro Val Met Thr Leu Pro Tyr Gly Ser Thr Arg Leu Thr Cys Arg Glu 
625                 630                 635                 640 

Ser Val Ile Asp Tyr Ile Val Asp Leu Glu Glu Lys Glu Ala Gln Lys 
                645                 650                 655     

Ala Val Ala Glu Gly Arg Thr Ala Asn Lys Val His Pro Phe Glu Asp 
            660                 665                 670         

Asp Arg Gln Asp Tyr Leu Thr Pro Gly Ala Ala Tyr Asn Tyr Met Thr 
        675                 680                 685             

Ala Leu Ile Trp Pro Ser Ile Ser Glu Val Val Lys Ala Pro Ile Val 
    690                 695                 700                 

Ala Met Lys Met Ile Arg Gln Leu Ala Arg Phe Ala Ala Lys Arg Asn 
705                 710                 715                 720 

Glu Gly Leu Met Tyr Thr Leu Pro Thr Gly Phe Ile Leu Glu Gln Lys 
                725                 730                 735     

Ile Met Ala Thr Glu Met Leu Arg Val Arg Thr Cys Leu Met Gly Asp 
            740                 745                 750         

Ile Lys Met Ser Leu Gln Val Glu Thr Asp Ile Val Asp Glu Ala Ala 
        755                 760                 765             

Met Met Gly Ala Ala Ala Pro Asn Phe Val His Gly His Asp Ala Ser 
    770                 775                 780                 

His Leu Ile Leu Thr Val Cys Glu Leu Val Asp Lys Gly Val Thr Ser 
785                 790                 795                 800 

Ile Ala Val Ile His Asp Ser Phe Gly Thr His Ala Asp Asn Thr Leu 
                805                 810                 815     

Thr Leu Arg Val Ala Leu Lys Gly Gln Met Val Ala Met Tyr Ile Asp 
            820                 825                 830         

Gly Asn Ala Leu Gln Lys Leu Leu Glu Glu His Glu Val Arg Trp Met 
        835                 840                 845             

Val Asp Thr Gly Ile Glu Val Pro Glu Gln Gly Glu Phe Asp Leu Asn 
    850                 855                 860                 

Glu Ile Met Asp Ser Glu Tyr Val Phe Ala 
865                 870                 

<210>   16
<211>   2625
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Bacteriophage SP6

<400>   16
atgcaagatt tacacgctat ccagcttcaa ttagaagaag agatgtttaa tggtggcatt  60
cgtcgcttcg aagcagatca acaacgccag attgcagcag gtagcgagag cgacacagca  120
tggaaccgcc gcctgttgtc agaacttatt gcacctatgg ctgaaggcat tcaggcttat  180
aaagaagagt acgaaggtaa gaaaggtcgt gcacctcgcg cattggcttt cttacaatgt  240
gtagaaaatg aagttgcagc atacatcact atgaaagttg ttatggatat gctgaatacg  300
gatgctaccc ttcaggctat tgcaatgagt gtagcagaac gcattgaaga ccaagtgcgc  360
ttttctaagc tagaaggtca cgccgctaaa tactttgaga aggttaagaa gtcactcaag  420
gctagccgta ctaagtcata tcgtcacgct cataacgtag ctgtagttgc tgaaaaatca  480
gttgcagaaa aggacgcgga ctttgaccgt tgggaggcgt ggccaaaaga aactcaattg  540
cagattggta ctaccttgct tgaaatctta gaaggtagcg ttttctataa tggtgaacct  600
gtatttatgc gtgctatgcg cacttatggc ggaaagacta tttactactt acaaacttct  660
gaaagtgtag gccagtggat tagcgcattc aaagagcacg tagcgcaatt aagcccagct  720
tatgcccctt gcgtaatccc tcctcgtcct tggagaactc catttaatgg agggttccat  780
actgagaagg tagctagccg tatccgtctt gtaaaaggta accgtgagca tgtacgcaag  840
ttgactcaaa agcaaatgcc aaaggtttat aaggctatca acgcattaca aaatacacaa  900
tggcaaatca acaaggatgt attagcagtt attgaagaag taatccgctt agaccttggt  960
tatggtgtac cttccttcaa gccactgatt gacaaggaga acaagccagc taacccggta  1020
cctgttgaat tccaacacct gcgcggtcgt gaactgaaag agatgctatc acctgagcag  1080
tggcaacaat tcattaactg gaaaggcgaa tgcgcgcgcc tatataccgc agaaactaag  1140
cgcggttcaa agtccgccgc cgttgttcgc atggtaggac aggcccgtaa atatagcgcc  1200
tttgaatcca tttacttcgt gtacgcaatg gatagccgca gccgtgtcta tgtgcaatct  1260
agcacgctct ctccgcagtc taacgactta ggtaaggcat tactccgctt taccgaggga  1320
cgccctgtga atggcgtaga agcgcttaaa tggttctgca tcaatggtgc taacctttgg  1380
ggatgggaca agaaaacttt tgatgtgcgc gtgtctaacg tattagatga ggaattccaa  1440
gatatgtgtc gagacatcgc cgcagaccct ctcacattca cccaatgggc taaagctgat  1500
gcaccttatg aattcctcgc ttggtgcttt gagtatgctc aataccttga tttggtggat  1560
gaaggaaggg ccgacgaatt ccgcactcac ctaccagtac atcaggacgg gtcttgttca  1620
ggcattcagc actatagtgc tatgcttcgc gacgaagtag gggccaaagc tgttaacctg  1680
aaaccctccg atgcaccgca ggatatctat ggggcggtgg cgcaagtggt tatcaagaag  1740
aatgcgctat atatggatgc ggacgatgca accacgttta cttctggtag cgtcacgctg  1800
tccggtacag aactgcgagc aatggctagc gcatgggata gtattggtat tacccgtagc  1860
ttaaccaaaa agcccgtgat gaccttgcca tatggttcta ctcgcttaac ttgccgtgaa  1920
tctgtgattg attacatcgt agacttagag gaaaaagagg cgcagaaggc agtagcagaa  1980
gggcggacgg caaacaaggt acatcctttt gaagacgatc gtcaagatta cttgactccg  2040
ggcgcagctt acaactacat gacggcacta atctggcctt ctatttctga agtagttaag  2100
gcaccgatag tagctatgaa gatgatacgc cagcttgcac gctttgcagc gaaacgtaat  2160
gaaggcctga tgtacaccct gcctactggc ttcatcttag aacagaagat catggcaacc  2220
gagatgctac gcgtgcgtac ctgtctgatg ggtgatatca agatgtccct tcaggttgaa  2280
acggatatcg tagatgaagc cgctatgatg ggagcagcag cacctaattt cgtacacggt  2340
catgacgcaa gtcaccttat ccttaccgta tgtgaattgg tagacaaggg cgtaactagt  2400
atcgctgtaa tccacgactc ttttggtact catgcagaca acaccctcac tcttagagtg  2460
gcacttaaag ggcagatggt tgcaatgtat attgatggta atgcgcttca gaaactactg  2520
gaggagcatg aagtgcgctg gatggttgat acaggtatcg aagtacctga gcaaggggag  2580
ttcgacctta acgaaatcat ggattctgaa tacgtatttg cctaa                  2625

<210>   17
<211>   18
<212>   DNA
<213>   Bacteriophage SP6

<400>   17
atttaggtga cactatag                                                18

<210>   18
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   18
atttagggga cactatagaa gag                                          23

<210>   19
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   19
atttagggga cactatagaa gg                                           22

<210>   20
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   20
atttagggga cactatagaa ggg                                          23

<210>   21
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   21
atttaggtga cactatagaa                                              20

<210>   22
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   22
atttaggtga cactatagaa ga                                           22

<210>   23
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   23
atttaggtga cactatagaa gag                                          23

<210>   24
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   24
atttaggtga cactatagaa gg                                           22

<210>   25
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   25
atttaggtga cactatagaa ggg                                          23

<210>   26
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<222>   (22)
<223>   n is a, c, g or t

<400>   26
atttaggtga cactatagaa gng                                          23

<210>   27
<211>   24
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   27
catacgattt aggtgacact atag                                         24

<210>   28
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Bacteriophage T7

<400>   28
taatacgact cactatag                                                18

<210>   29
<211>   15
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<400>   29
gctatctgtt catca                                                   15

<210>   30
<211>   16
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(4)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   gm

<220>
<221>   modified_base
<222>   (2)
<223>   am

<220>
<221>   modified_base
<222>   (3)
<223>   um

<220>
<221>   modified_base
<222>   (4)
<223>   gm

<220>
<221>   misc_feature
<222>   (5)...(8)
<223>   DNA

<220>
<221>   misc_feature
<222>   (9)...(16)
<223>   RNA

<220>
<221>   modified_base
<222>   (9)
<223>   um

<220>
<221>   modified_base
<222>   (10)
<223>   um

<220>
<221>   modified_base
<222>   (11)
<223>   am

<220>
<221>   modified_base
<222>   (12)
<223>   am

<220>
<221>   modified_base
<222>   (13)
<223>   um

<220>
<221>   modified_base
<222>   (14)
<223>   um

<220>
<221>   modified_base
<222>   (15)
<223>   um

<220>
<221>   modified_base
<222>   16
<223>   um

<400>   30
gaugcaacuu aauuuu                                                  16

<210>   31
<211>   18
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(7)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   am

<220>
<221>   modified_base
<222>   (2)
<223>   gm

<220>
<221>   modified_base
<222>   (3)
<223>   cm

<220>
<221>   modified_base
<222>   (4)
<223>   um

<220>
<221>   modified_base
<222>   (5)
<223>   um

<220>
<221>   modified_base
<222>   (6)
<223>   gm

<220>
<221>   modified_base
<222>   (7)
<223>   am

<220>
<221>   misc_feature
<222>   (8)...(11)
<223>   DNA

<220>
<221>   misc_feature
<222>   (12)...(18)
<223>   RNA

<220>
<221>   modified_base
<222>   (12)
<223>   am

<220>
<221>   modified_base
<222>   (13)
<223>   cm

<220>
<221>   modified_base
<222>   (14)
<223>   um

<220>
<221>   modified_base
<222>   (15)
<223>   um

<220>
<221>   modified_base
<222>   (16)
<223>   am

<220>
<221>   modified_base
<222>   (17)
<223>   am

<220>
<221>   modified_base
<222>   (18)
<223>   um

<400>   31
agcuugatgc aacuuaau                                                18

<210>   32
<211>   16
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(5)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   am

<220>
<221>   modified_base
<222>   (2)
<223>   gm

<220>
<221>   modified_base
<222>   (3)
<223>   cm

<220>
<221>   modified_base
<222>   (4)
<223>   um

<220>
<221>   modified_base
<222>   (5)
<223>   um

<220>
<221>   misc_feature
<222>   (6)...(9)
<223>   DNA

<220>
<221>   misc_feature
<222>   (10)...(16)
<223>   RNA

<220>
<221>   modified_base
<222>   (10)
<223>   cm

<220>
<221>   modified_base
<222>   (11)
<223>   am

<220>
<221>   modified_base
<222>   (12)
<223>   am

<220>
<221>   modified_base
<222>   (13)
<223>   cm

<220>
<221>   modified_base
<222>   (14)
<223>   um

<220>
<221>   modified_base
<222>   (15)
<223>   um

<220>
<221>   modified_base
<222>   (16)
<223>   am

<400>   32
agcuugatgc aacuua                                                  16

<210>   33
<211>   16
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(3)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   am

<220>
<221>   modified_base
<222>   (2)
<223>   gm

<220>
<221>   modified_base
<222>   (3)
<223>   cm

<220>
<221>   misc_feature
<222>   (4)...(7)
<223>   DNA

<220>
<221>   misc_feature
<222>   (8)...(16)
<223>   RNA

<220>
<221>   modified_base
<222>   (8)
<223>   um

<220>
<221>   modified_base
<222>   (9)
<223>   gm

<220>
<221>   modified_base
<222>   (10)
<223>   cm

<220>
<221>   modified_base
<222>   (11)
<223>   am

<220>
<221>   modified_base
<222>   (12)
<223>   am

<220>
<221>   modified_base
<222>   (13)
<223>   cm

<220>
<221>   modified_base
<222>   (14)
<223>   um

<220>
<221>   modified_base
<222>   (15)
<223>   um

<220>
<221>   modified_base
<222>   (16)
<223>   am

<400>   33
agcttgaugc aacuua                                                  16

<210>   34
<211>   14
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(7)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   am

<220>
<221>   modified_base
<222>   (2)
<223>   gm

<220>
<221>   modified_base
<222>   (3)
<223>   cm

<220>
<221>   modified_base
<222>   (4)
<223>   um

<220>
<221>   modified_base
<222>   (5)
<223>   um

<220>
<221>   modified_base
<222>   (6)
<223>   gm

<220>
<221>   modified_base
<222>   (7)
<223>   am

<220>
<221>   misc_feature
<222>   (8)...(11)
<223>   DNA

<220>
<221>   misc_feature
<222>   (12)...(14)
<223>   RNA

<220>
<221>   modified_base
<222>   (12)
<223>   am

<220>
<221>   modified_base
<222>   (13)
<223>   cm

<220>
<221>   modified_base
<222>   (14)
<223>   um

<400>   34
agcuugatgc aacu                                                    14

<210>   35
<211>   11
<212>   Combined DNA/RNA
<213>   Artificial Sequence

<220>
<223>   Synthetic oligonucleotide

<220>
<221>   misc_feature
<223>   /note="Combined DNA / RNA"

<220>
<221>   misc_feature
<222>   (1)...(5)
<223>   RNA

<220>
<221>   modified_base
<222>   (1)
<223>   cm

<220>
<221>   modified_base
<222>   (2)
<223>   um

<220>
<221>   modified_base
<222>   (3)
<223>   um

<220>
<221>   modified_base
<222>   (4)
<223>   gm

<220>
<221>   modified_base
<222>   (5)
<223>   am

<220>
<221>   misc_feature
<222>   (6)...(9)
<223>   DNA

<220>
<221>   misc_feature
<222>   (10)...(11)
<223>   RNA

<220>
<221>   modified_base
<222>   (10)
<223>   am

<220>
<221>   modified_base
<222>   (11)
<223>   cm

<400>   35
cuugatgcaa c                                                       11

