                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  LIGHT-INDUCIBLE GENE ACTIVATION SYSTEMS AND METHODS FOR MAKING 
       AND USING THEM

<130>  0321.140144PCT/SD2019-335

<140>  to be assigned
<141>  2021-02-17

<150>  62/977,569
<151>  2020-02-17

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  574
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  1

Met Lys Ala Leu Thr Ala Arg Gln Gln Glu Val Phe Asp Leu Ile Arg 
1               5                   10                  15      


Asp His Ile Ser Gln Thr Gly Met Pro Pro Thr Arg Ala Glu Ile Ala 
            20                  25                  30          


Gln Arg Leu Gly Phe Arg Ser Pro Asn Ala Ala Glu Glu His Leu Lys 
        35                  40                  45              


Ala Leu Ala Arg Lys Gly Val Ile Glu Ile Val Ser Gly Ala Ser Arg 
    50                  55                  60                  


Gly Ile Arg Leu Leu Gln Glu Glu Glu Glu Gly Leu Pro Leu Val Gly 
65                  70                  75                  80  


Arg Val Ala Ala Gly Glu Pro Ala Ser Gly Gly Gly Gly Ser Gly Gly 
                85                  90                  95      


Gly Gly Ser Asn Gly Ala Ile Gly Gly Asp Leu Leu Leu Asn Phe Pro 
            100                 105                 110         


Asp Met Ser Val Leu Glu Arg Gln Arg Ala His Leu Lys Tyr Leu Asn 
        115                 120                 125             


Pro Thr Phe Asp Ser Pro Leu Ala Gly Phe Phe Ala Asp Ser Ser Met 
    130                 135                 140                 


Ile Thr Gly Gly Glu Met Asp Ser Tyr Leu Ser Thr Ala Gly Leu Asn 
145                 150                 155                 160 


Leu Pro Met Met Tyr Gly Glu Thr Thr Val Glu Gly Asp Ser Arg Leu 
                165                 170                 175     


Ser Ile Ser Pro Glu Thr Thr Leu Gly Thr Gly Asn Phe Lys Ala Ala 
            180                 185                 190         


Lys Phe Asp Thr Glu Thr Lys Asp Cys Asn Glu Ala Ala Lys Lys Met 
        195                 200                 205             


Thr Met Asn Arg Asp Asp Leu Val Glu Glu Gly Glu Glu Glu Lys Ser 
    210                 215                 220                 


Lys Ile Thr Glu Gln Asn Asn Gly Ser Thr Lys Ser Ile Lys Lys Met 
225                 230                 235                 240 


Lys His Lys Ala Lys Lys Glu Glu Asn Asn Phe Ser Asn Asp Ser Ser 
                245                 250                 255     


Lys Val Thr Lys Glu Leu Glu Lys Thr Asp Tyr Ile His Val Arg Ala 
            260                 265                 270         


Arg Arg Gly Gln Ala Thr Asp Ser His Ser Ile Ala Glu Arg Val Arg 
        275                 280                 285             


Arg Glu Lys Ile Ser Glu Arg Met Lys Phe Leu Gln Asp Leu Val Pro 
    290                 295                 300                 


Gly Cys Asp Lys Ile Thr Gly Lys Ala Gly Met Leu Asp Glu Ile Ile 
305                 310                 315                 320 


Asn Tyr Val Gln Ser Leu Gln Arg Gln Ile Glu Phe Leu Ser Met Lys 
                325                 330                 335     


Leu Ala Ile Val Asn Pro Arg Pro Asp Phe Asp Met Asp Asp Ile Phe 
            340                 345                 350         


Ala Lys Glu Val Ala Ser Thr Pro Met Thr Val Val Pro Ser Pro Glu 
        355                 360                 365             


Met Val Leu Ser Gly Tyr Ser His Glu Met Val His Ser Gly Tyr Ser 
    370                 375                 380                 


Ser Glu Met Val Asn Ser Gly Tyr Leu His Val Asn Pro Met Gln Gln 
385                 390                 395                 400 


Val Asn Thr Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe Val Ile Thr Asp 
            420                 425                 430         


Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser Asp Ser Phe Leu 
        435                 440                 445             


Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly Arg Asn Cys Arg 
    450                 455                 460                 


Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val Arg Lys Ile Arg 
465                 470                 475                 480 


Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln Leu Ile Asn Tyr 
                485                 490                 495     


Thr Lys Ser Gly Lys Lys Phe Trp Asn Leu Phe His Leu Gln Pro Met 
            500                 505                 510         


Arg Asp Gln Lys Gly Asp Val Gln Tyr Phe Ile Gly Val Gln Leu Asp 
        515                 520                 525             


Gly Thr Glu His Val Arg Asp Ala Ala Glu Arg Glu Gly Val Met Leu 
    530                 535                 540                 


Ile Lys Lys Thr Ala Glu Asn Ile Asp Glu Ala Ala Lys Arg Leu Pro 
545                 550                 555                 560 


Asp Ala Asn Leu Ala Ala Ala Ala Lys Lys Lys Lys Leu Asp 
                565                 570                 


<210>  2
<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide

<400>  2

Met Lys Met Asp Lys Lys Thr Ile Val Trp Phe Arg Arg Asp Leu Arg 
1               5                   10                  15      


Ile Glu Asp Asn Pro Ala Leu Ala Ala Ala Ala His Glu Gly Ser Val 
            20                  25                  30          


Phe Pro Val Phe Ile Trp Cys Pro Glu Glu Glu Gly Gln Phe Tyr Pro 
        35                  40                  45              


Gly Arg Ala Ser Arg Trp Trp Met Lys Gln Ser Leu Ala His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Lys Ala Leu Gly Ser Asp Leu Thr Leu Ile Lys Thr His 
65                  70                  75                  80  


Asn Thr Ile Ser Ala Ile Leu Asp Cys Ile Arg Val Thr Gly Ala Thr 
                85                  90                  95      


Lys Val Val Phe Asn His Leu Tyr Asp Pro Val Ser Leu Val Arg Asp 
            100                 105                 110         


His Thr Val Lys Glu Lys Leu Val Glu Arg Gly Ile Ser Val Gln Ser 
        115                 120                 125             


Tyr Asn Gly Asp Leu Leu Tyr Glu Pro Trp Glu Ile Tyr Cys Glu Lys 
    130                 135                 140                 


Gly Lys Pro Phe Thr Ser Phe Asn Ser Tyr Trp Lys Lys Cys Leu Asp 
145                 150                 155                 160 


Met Ser Ile Glu Ser Val Met Leu Pro Pro Pro Trp Arg Leu Met Pro 
                165                 170                 175     


Ile Thr Ala Ala Ala Glu Ala Ile Trp Ala Cys Ser Ile Glu Glu Leu 
            180                 185                 190         


Gly Leu Glu Asn Glu Ala Glu Lys Pro Ser Asn Ala Leu Leu Thr Arg 
        195                 200                 205             


Ala Trp Ser Pro Gly Trp Ser Asn Ala Asp Lys Leu Leu Asn Glu Phe 
    210                 215                 220                 


Ile Glu Lys Gln Leu Ile Asp Tyr Ala Lys Asn Ser Lys Lys Val Val 
225                 230                 235                 240 


Gly Asn Ser Thr Ser Leu Leu Ser Pro Tyr Leu His Phe Gly Glu Ile 
                245                 250                 255     


Ser Val Arg His Val Phe Gln Cys Ala Arg Met Lys Gln Ile Ile Trp 
            260                 265                 270         


Ala Arg Asp Lys Asn Ser Glu Gly Glu Glu Ser Ala Asp Leu Phe Leu 
        275                 280                 285             


Arg Gly Ile Gly Leu Arg Glu Tyr Ser Arg Tyr Ile Cys Phe Asn Phe 
    290                 295                 300                 


Pro Phe Thr His Glu Gln Ser Leu Leu Ser His Leu Arg Phe Phe Pro 
305                 310                 315                 320 


Trp Asp Ala Asp Val Asp Lys Phe Lys Ala Trp Arg Gln Gly Arg Thr 
                325                 330                 335     


Gly Tyr Pro Leu Val Asp Ala Gly Met Arg Glu Leu Trp Ala Thr Gly 
            340                 345                 350         


Trp Met His Asn Arg Ile Arg Val Ile Val Ser Ser Phe Ala Val Lys 
        355                 360                 365             


Phe Leu Leu Leu Pro Trp Lys Trp Gly Met Lys Tyr Phe Trp Asp Thr 
    370                 375                 380                 


Leu Leu Asp Ala Asp Leu Glu Cys Asp Ile Leu Gly Trp Gln Tyr Ile 
385                 390                 395                 400 


Ser Gly Ser Ile Pro Asp Gly His Glu Leu Asp Arg Leu Asp Asn Pro 
                405                 410                 415     


Ala Leu Gln Gly Ala Lys Tyr Asp Pro Glu Gly Glu Tyr Ile Arg Gln 
            420                 425                 430         


Trp Leu Pro Glu Leu Ala Arg Leu Pro Thr Glu Trp Ile His His Pro 
        435                 440                 445             


Trp Asp Ala Pro Leu Thr Val Leu Lys Ala Ser Gly Val Glu Leu Gly 
    450                 455                 460                 


Thr Asn Tyr Ala Lys Pro Ile Val Asp Ile Asp Thr Ala Arg Glu Leu 
465                 470                 475                 480 


Leu Ala Lys Ala Ile Ser Arg Thr Arg Glu Ala Gln Ile Met Ile Gly 
                485                 490                 495     


Ala Ala Pro Ala Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser 
            500                 505                 510         


Pro Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys 
        515                 520                 525             


Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu 
    530                 535                 540                 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
545                 550                 555                 560 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
                565                 570                 575     


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile 
            580                 585                 590         


Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser 
        595                 600                 605             


Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
    610                 615                 620                 


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
625                 630                 635                 640 


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
                645                 650                 655     


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
            660                 665                 670         


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
        675                 680                 685             


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
    690                 695                 700                 


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
705                 710                 715                 720 


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
                725                 730                 735     


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
            740                 745                 750         


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
        755                 760                 765             


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
    770                 775                 780                 


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
785                 790                 795                 800 


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
                805                 810                 815     


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
            820                 825                 830         


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
        835                 840                 845             


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
    850                 855                 860                 


Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly 
865                 870                 875                 880 


Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe 
                885                 890                 895     


Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro 
            900                 905                 910         


Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro 
        915                 920                 925             


Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala 
    930                 935                 940                 


Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala 
945                 950                 955                 960 


Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys 
                965                 970                 975     


Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala 
            980                 985                 990         


Ala Ile Cys Gly Gln Met Asp Leu  Ser His Pro Pro Pro  Arg Gly His 
        995                 1000                 1005             


Leu Asp  Glu Leu Thr Thr Thr  Leu Glu Ser Met Thr  Glu Asp Leu 
    1010                 1015                 1020             


Asn Leu  Asp Ser Pro Leu Thr  Pro Glu Leu Asn Glu  Ile Leu Asp 
    1025                 1030                 1035             


Thr Phe  Leu Asn Asp Glu Cys  Leu Leu His Ala Met  His Ile Ser 
    1040                 1045                 1050             


Thr Gly  Leu Ser Ile Phe Asp  Thr Ser Leu Phe 
    1055                 1060                 


