                         SEQUENCE LISTING

<110>  ALECTOR LLC
 
<120>  PILRA ANTIBODIES AND METHODS OF USE THEREOF

<130>  4503.009PC02

<150>  US 62/978,106
<151>  2020-02-18

<150>  US 63/075,440
<151>  2020-09-08

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Arg Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Val Gly Val Ala Val Ala Val Thr Val Leu Gly 
        195                 200                 205             


Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp Arg Arg Arg Lys 
    210                 215                 220                 


Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg Glu Pro Phe Gln 
225                 230                 235                 240 


Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu Gly Gln Asn Thr 
                245                 250                 255     


Asp Pro Lys Leu Asn Pro Lys Asp Asp Gly Ile Val Tyr Ala Ser Leu 
            260                 265                 270         


Ala Leu Ser Ser Ser Thr Ser Pro Arg Ala Pro Pro Ser His Arg Pro 
        275                 280                 285             


Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val Leu Lys Ala 
    290                 295                 300             


<210>  2
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus monkey PILRA

<400>  2

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Leu Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Phe Leu Gln Pro Gly Gly Ser Ala Gly Ser Gly 
            20                  25                  30          


Pro Ser Gly Pro Tyr Gly Val Thr Gln Arg Lys His Leu Ser Ala Pro 
        35                  40                  45              


Met Gly Gly Ser Val Glu Ile Pro Phe Ser Phe Tyr His Pro Trp Glu 
    50                  55                  60                  


Leu Ala Ala Ala Pro Asn Met Lys Ile Ser Trp Arg Arg Gly Asn Phe 
65                  70                  75                  80  


His Gly Glu Phe Phe Tyr Arg Thr Arg Pro Ala Phe Ile His Glu Asp 
                85                  90                  95      


Tyr Ser Asn Arg Leu Leu Leu Asn Trp Thr Glu Gly Gln Asp Arg Gly 
            100                 105                 110         


Leu Leu Arg Ile Trp Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe 
        115                 120                 125             


Cys Arg Val Glu Leu Asp Thr Arg Arg Ser Gly Arg Gln Arg Trp Gln 
    130                 135                 140                 


Ser Ile Glu Gly Thr Lys Leu Thr Ile Thr Gln Ala Val Thr Thr Thr 
145                 150                 155                 160 


Thr Gln Arg Pro Ser Ser Met Thr Thr Thr Arg Arg Pro Ser Ser Ala 
                165                 170                 175     


Thr Thr Thr Ala Gly Leu Arg Val Thr Gln Gly Lys Arg His Ser Asp 
            180                 185                 190         


Ser Trp His Leu Ser Leu Lys Thr Ala Val Gly Val Thr Val Ala Val 
        195                 200                 205             


Ala Val Leu Gly Ile Met Ile Leu Gly Leu Ile Cys Leu Leu Arg Trp 
    210                 215                 220                 


Arg Arg Arg Lys Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Lys 
225                 230                 235                 240 


Glu Pro Phe Gln Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu 
                245                 250                 255     


Gly Gln Asn Thr Asp Pro Lys Pro Asn Pro Lys Asp Asp Gly Ile Val 
            260                 265                 270         


Tyr Ala Ser Leu Ala Leu Ser Ser Ser Thr Ser Pro Arg Val Pro Pro 
        275                 280                 285             


Ser His His Pro Leu Lys Ser Pro Gln Asn Glu Thr Leu Tyr Ser Val 
    290                 295                 300                 


Leu Lys Val 
305         


<210>  3
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine PILRA

<400>  3

Met Ala Leu Leu Ile Ser Leu Pro Gly Gly Thr Pro Ala Met Ala Gln 
1               5                   10                  15      


Ile Leu Leu Leu Leu Ser Ser Ala Cys Leu His Ala Gly Asn Ser Glu 
            20                  25                  30          


Arg Ser Asn Arg Lys Asn Gly Phe Gly Val Asn Gln Pro Glu Ser Cys 
        35                  40                  45              


Ser Gly Val Gln Gly Gly Ser Ile Asp Ile Pro Phe Ser Phe Tyr Phe 
    50                  55                  60                  


Pro Trp Lys Leu Ala Lys Asp Pro Gln Met Ser Ile Ala Trp Arg Trp 
65                  70                  75                  80  


Lys Asp Phe His Gly Glu Phe Ile Tyr Asn Ser Ser Leu Pro Phe Ile 
                85                  90                  95      


His Glu His Phe Lys Gly Arg Leu Ile Leu Asn Trp Thr Gln Gly Gln 
            100                 105                 110         


Thr Ser Gly Val Leu Arg Ile Leu Asn Leu Lys Glu Ser Asp Gln Thr 
        115                 120                 125             


Arg Tyr Phe Gly Arg Val Phe Leu Gln Thr Thr Glu Gly Ile Gln Phe 
    130                 135                 140                 


Trp Gln Ser Ile Pro Gly Thr Gln Leu Asn Val Thr Asn Ala Thr Cys 
145                 150                 155                 160 


Thr Pro Thr Thr Leu Pro Ser Thr Thr Ala Ala Thr Ser Ala His Thr 
                165                 170                 175     


Gln Asn Asp Ile Thr Glu Val Lys Ser Ala Asn Ile Gly Gly Leu Asp 
            180                 185                 190         


Leu Gln Thr Thr Val Gly Leu Ala Thr Ala Ala Ala Val Phe Leu Val 
        195                 200                 205             


Gly Val Leu Gly Leu Ile Val Phe Leu Trp Trp Lys Arg Arg Arg Gln 
    210                 215                 220                 


Gly Gln Lys Thr Lys Ala Glu Ile Pro Ala Arg Glu Pro Leu Glu Thr 
225                 230                 235                 240 


Ser Glu Lys His Glu Ser Val Gly His Glu Gly Gln Cys Met Asp Pro 
                245                 250                 255     


Lys Glu Asn Pro Lys Asp Asn Asn Ile Val Tyr Ala Ser Ile Ser Leu 
            260                 265                 270         


Ser Ser Pro Thr Ser Pro Gly Thr Ala Pro Asn Leu Pro Val His Gly 
        275                 280                 285             


Asn Pro Gln Glu Glu Thr Val Tyr Ser Ile Val Lys Ala Lys 
    290                 295                 300         


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-002 Heavy Chain CDR1

<400>  4

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-002 heavy chain CDR2

<400>  5

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Heavy chain CDR3

<400>  6

Val Glu Asp Tyr Gly Asn Pro Phe Asp Tyr 
1               5                   10  


<210>  7
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain CDR1

<400>  7

His Ala Ser Gln Asn Ile His Val Trp Leu Asn 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain CDR2

<400>  8

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain CDR3

<400>  9

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-005 Heavy Chain CDR1

<400>  10

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  11
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Heavy Chain CDR2

<400>  11

His Ile Trp Trp Asp Asp Asp Lys Phe Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Heavy Chain CDR3

<400>  12

Ile Glu Asp Tyr Gly Ser Tyr Phe Ala Tyr 
1               5                   10  


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-005 Light Chain CDR1

<400>  13

His Ala Ser Gln Asn Ile His Val Trp Leu Asn 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-005 Light Chain CDR2

<400>  14

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Light Chain CDR3

<400>  15

Gln Gln Gly Gln Ser Tyr Pro Tyr Thr 
1               5                   


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-004 Heavy Chain CDR1

<400>  16

Ser Phe Gly Val Ala Val Gly 
1               5           


<210>  17
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain CDR2

<400>  17

His Ile Trp Trp Asp Asp Asp Lys Ser Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain CDR3

<400>  18

Ile Ala Asp Tyr Gly Asn His Phe Asp Tyr 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain CDR1

<400>  19

His Ala Ser Gln Asn Ser His Val Trp Leu Ser 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-004 Light Chain CDR2

<400>  20

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain CDR3

<400>  21

Gln Gln Gly Gln Thr Tyr Pro Phe Thr 
1               5                   


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-001 Heavy Chain CDR1

<400>  22

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  23
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain CDR2

<400>  23

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  24
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain CDR3

<400>  24

Ile Glu Asp Tyr Gly Asn Pro Phe Asp Tyr 
1               5                   10  


<210>  25
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain CDR1

<400>  25

His Ala Ser Gln Asn Ile His Val Trp Leu Ser 
1               5                   10      


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain CDR2

<400>  26

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain CDR3

<400>  27

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  28
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-002 Variable Heavy Chain

<400>  28

Gln Val Thr Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Glu Asp Tyr Gly Asn Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  29
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Variable Light Chain

<400>  29

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile His Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Val Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  30
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Variable Heavy Chain

<400>  30

Gln Val Ile Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Ser Leu Ala His Ile Trp Trp Asp Asp Asp Lys Phe Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ile Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ile Glu Asp Tyr Gly Ser Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Variable Light Chain

<400>  31

Asp Val Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Pro Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile His Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Asn Ile Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  32
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Variable Heavy Chain

<400>  32

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Met Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Ala Cys Ser Phe Ser Gly Phe Ser Leu Asn Ser Phe 
            20                  25                  30          


Gly Val Ala Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Ser Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Leu Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Thr Arg Ile Ala Asp Tyr Gly Asn His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ala Leu Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Variable Light Chain

<400>  33

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ser His Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Variable Heavy Chain

<400>  34

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ile Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Glu Asp Tyr Gly Asn Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-001 Variable Light Chain

<400>  35

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile His Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  36
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Heavy Chain Framework Region 1

<400>  36

Gln Val Thr Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  37
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Heavy Chain Framework Region 2

<400>  37

Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  38
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Heavy Chain Framework Region 3

<400>  38

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu Lys 
1               5                   10                  15      


Ile Ala Ser Val Asp Thr Ala Asp Ile Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  39
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Heavy Chain Framework Region 4

<400>  39

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  40
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain Framework Region 1

<400>  40

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys 
            20              


<210>  41
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain Framework Region 2

<400>  41

Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  42
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain Framework Region 3

<400>  42

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr 
1               5                   10                  15      


Val Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  43
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-002 Light Chain Framework Region 4

<400>  43

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  44
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hPA-005 Heavy Chain Framework Region 1

<400>  44

Gln Val Ile Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  45
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Heavy Chain Framework Region 2

<400>  45

Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Ser Leu Ala 
1               5                   10                  


<210>  46
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Heavy Chain Framework Region 3

<400>  46

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Ile Ala Asn Val Asp Thr Ala Asp Ile Ala Thr Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  47
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Heavy Chain Framework Region 4

<400>  47

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  48
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Light Chain Framework Region 1

<400>  48

Asp Val Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Pro Ile Thr Ile Thr Cys 
            20              


<210>  49
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Light Chain Framework Region 2

<400>  49

Trp Tyr Gln Gln Arg Pro Gly Asn Ile Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  50
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Light Chain Framework Region 3

<400>  50

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  51
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-005 Light Chain Framework Region 4

<400>  51

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  52
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain Framework Region 1

<400>  52

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Met Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Ala Cys Ser Phe Ser Gly Phe Ser Leu Asn 
            20                  25                  30  


<210>  53
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain Framework Region 2

<400>  53

Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  54
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain Framework Region 3

<400>  54

Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Phe Leu Lys 
1               5                   10                  15      


Leu Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  55
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Heavy Chain Framework Region 4

<400>  55

Trp Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
1               5                   10      


<210>  56
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain Framework Region 1

<400>  56

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys 
            20              


<210>  57
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain Framework Region 2

<400>  57

Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  58
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain Framework Region 3

<400>  58

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Gly Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  59
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-004 Light Chain Framework Region 4

<400>  59

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  60
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain Framework Region 1

<400>  60

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  61
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain Framework Region 2

<400>  61

Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala 
1               5                   10                  


<210>  62
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain Framework Region 3

<400>  62

Arg Leu Thr Ile Ser Lys Asp Ile Ser Lys Asn Gln Val Phe Leu Lys 
1               5                   10                  15      


Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  63
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Heavy Chain Framework Region 4

<400>  63

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  64
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain Framework Region 1

<400>  64

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys 
            20              


<210>  65
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain Framework Region 2

<400>  65

Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain Framework Region 3

<400>  66

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  67
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hPA-001 Light Chain Framework Region 4

<400>  67

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  68
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Leu Leu Leu Gln Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Gly Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Ile Val 
    50                  55                  60                  


Pro Asn Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Glu Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Arg Lys Glu Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Arg Ser Gly Arg Gln Gln Leu Gln Ser Ile Lys Gly 
    130                 135                 140                 


Thr Lys Leu Thr Ile Thr Gln Ala Val Thr Thr Thr Thr Thr Trp Arg 
145                 150                 155                 160 


Pro Ser Ser Thr Thr Thr Ile Ala Gly Leu Arg Val Thr Glu Ser Lys 
                165                 170                 175     


Gly His Ser Glu Ser Trp His Leu Ser Leu Asp Thr Ala Ile Arg Val 
            180                 185                 190         


Ala Leu Ala Val Ala Val Leu Lys Thr Val Ile Leu Gly Leu Leu Cys 
        195                 200                 205             


Leu Leu Leu Leu Trp Trp Arg Arg Arg Lys Gly Ser Arg Ala Pro Ser 
    210                 215                 220                 


Ser Asp Phe 
225         


<210>  69
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  human IgG1 Fc domain

<400>  69

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  70
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated human IgG1 Fc

<400>  70

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Ser Lys Ala 
            100                 105                 110         


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  71
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated human IgG1 Fc

<400>  71

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  72
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  human IgG4 Fc

<400>  72

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  73
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated human IgG4 Fc

<400>  73

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  74
<211>  445
<212>  PRT
<213>  artificial sequence

<220>
<223>  soluble human PILRA hIgG1 Fc

<400>  74

Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu Tyr Gly Val 
1               5                   10                  15      


Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser Val Glu Ile 
            20                  25                  30          


Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala Pro Asp Val 
        35                  40                  45              


Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser Phe Tyr Ser 
    50                  55                  60                  


Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg Leu Phe Leu 
65                  70                  75                  80  


Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile Ser Asn Leu 
                85                  90                  95      


Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu Leu Asp Thr 
            100                 105                 110         


Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly Thr Lys Leu 
        115                 120                 125             


Ser Ile Thr Gln Gly Gln Gln Arg Thr Lys Ala Thr Thr Pro Ala Arg 
    130                 135                 140                 


Glu Pro Phe Gln Asn Thr Glu Glu Pro Tyr Glu Asn Ile Arg Asn Glu 
145                 150                 155                 160 


Gly Gln Asn Thr Asp Pro Lys Leu Asn Pro Lys Leu His Leu Thr Gln 
                165                 170                 175     


Ser Thr Ser Gln Pro Pro Ser Pro Gln Glu Pro Pro Glu Arg Asp Pro 
            180                 185                 190         


Val Leu Cys Leu Lys Gly Leu Thr Asn Gly Gln Pro Ser Gln Asp Ala 
        195                 200                 205             


Asp Asp Asp Asp Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  75
<211>  428
<212>  PRT
<213>  artificial sequence

<220>
<223>  PILRA mFc

<400>  75

Met Gly Arg Pro Leu Leu Leu Pro Leu Leu Pro Leu Leu Leu Pro Pro 
1               5                   10                  15      


Ala Phe Leu Gln Pro Ser Gly Ser Thr Gly Ser Gly Pro Ser Tyr Leu 
            20                  25                  30          


Tyr Gly Val Thr Gln Pro Lys His Leu Ser Ala Ser Met Gly Gly Ser 
        35                  40                  45              


Val Glu Ile Pro Phe Ser Phe Tyr Tyr Pro Trp Glu Leu Ala Thr Ala 
    50                  55                  60                  


Pro Asp Val Arg Ile Ser Trp Arg Arg Gly His Phe His Gly Gln Ser 
65                  70                  75                  80  


Phe Tyr Ser Thr Arg Pro Pro Ser Ile His Lys Asp Tyr Val Asn Arg 
                85                  90                  95      


Leu Phe Leu Asn Trp Thr Glu Gly Gln Lys Ser Gly Phe Leu Arg Ile 
            100                 105                 110         


Ser Asn Leu Gln Lys Gln Asp Gln Ser Val Tyr Phe Cys Arg Val Glu 
        115                 120                 125             


Leu Asp Thr Arg Ser Ser Gly Arg Gln Gln Trp Gln Ser Ile Glu Gly 
    130                 135                 140                 


Thr Lys Leu Ser Ile Thr Gln Ala Val Thr Thr Thr Thr Gln Arg Pro 
145                 150                 155                 160 


Ser Ser Met Thr Thr Thr Trp Arg Leu Ser Ser Thr Thr Thr Thr Thr 
                165                 170                 175     


Gly Leu Arg Val Thr Gln Gly Lys Arg Arg Ser Asp Ser Trp His Ile 
            180                 185                 190         


Ser Leu Glu Thr Ala Gly Gly Ser Gly Val Pro Arg Asp Cys Gly Cys 
        195                 200                 205             


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
                245                 250                 255     


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
            260                 265                 270         


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
        275                 280                 285             


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
    290                 295                 300                 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
305                 310                 315                 320 


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
                325                 330                 335     


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
            340                 345                 350         


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
        355                 360                 365             


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
    370                 375                 380                 


Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
385                 390                 395                 400 


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
                405                 410                 415     


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
            420                 425             


