                         SEQUENCE LISTING

<110>  THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
 
<120>  Anti-Endoglin Antagonist Antibody

<130>  50425-750

<140>  PCT/US21/018332
<141>  2021-02-17

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  HOMO SAPIENS

<400>  1

Thr Thr Gly Glu Tyr Ser Phe Lys Ile Phe Pro 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  HOMO SAPIENS

<400>  2

Thr Thr Gly Glu Tyr Ser Val Lys Ile Phe Pro 
1               5                   10      


<210>  3
<211>  8
<212>  PRT
<213>  MURINE SP.

<400>  3

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  4
<211>  10
<212>  PRT
<213>  MURINE SP.

<400>  4

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  MURINE SP.

<400>  5

Val Arg Asp Arg Thr Gly Ser Trp Phe Ala Tyr 
1               5                   10      


<210>  6
<211>  6
<212>  PRT
<213>  MURINE SP.

<400>  6

Gln Asp Ile Gly Ser Ser 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  MURINE SP.

<400>  7

Ala Thr Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  MURINE SP.

<400>  8

Leu Gln Tyr Ala Ser Ser Pro Tyr Thr 
1               5                   


<210>  9
<211>  218
<212>  PRT
<213>  MURINE SP.

<400>  9

Met Val Leu Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Arg Asp Arg Thr Gly Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Glu Ser Gln Ser Phe 
    130                 135                 140                 


Pro Asn Val Phe Pro Leu Val Ser Cys Glu Ser Pro Leu Ser Asp Lys 
145                 150                 155                 160 


Asn Leu Val Ala Met Gly Cys Leu Ala Arg Asp Phe Leu Pro Ser Thr 
                165                 170                 175     


Ile Ser Phe Thr Trp Asn Tyr Gln Asn Asn Thr Glu Val Ile Gln Ser 
            180                 185                 190         


Ile Arg Thr Phe Pro Thr Leu Arg Thr Gly Gly Lys Tyr Leu Ala Thr 
        195                 200                 205             


Ser Gln Val Leu Leu Ser Pro Lys Ser Ile 
    210                 215             


<210>  10
<211>  654
<212>  DNA
<213>  MURINE SP.

<400>  10
atggtgttgg ggcttaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag       60

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aaggatcatt gaaactctca      120

tgtgccgcct ctggtttcac cttcaatacc tatgccatgc actgggtccg ccaggctcca      180

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtagtaatta tgcaacatat      240

tatgccgatt cagtgaaaga cagattcacc atctccagag atgattcaca aagcatgctc      300

tatctgcaaa tgaacaacct gaaaactgag gacacagcca tgtattactg tgtgagagat      360

agaactgggt cctggtttgc ttactggggc caagggactc tggtcactgt ctctgcagag      420

agtcagtcct tcccaaatgt cttccccctc gtctcctgcg agagccccct gtctgataag      480

aatctggtgg ccatgggctg cctggcccgg gacttcctgc ccagcaccat ttccttcacc      540

tggaactacc agaacaacac tgaagtcatc cagagtatca gaaccttccc aacactgagg      600

acagggggca agtacctagc cacctcgcag gtcttgctgt ctcccaagag catc            654


<210>  11
<211>  203
<212>  PRT
<213>  MURINE SP.

<400>  11

Met Arg Ala Pro Ala Gln Ile Phe Gly Phe Leu Leu Leu Leu Phe Pro 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Gly Ser Ser Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200             


<210>  12
<211>  609
<212>  DNA
<213>  MURINE SP.

<400>  12
atgagggctc ctgcacaaat ttttggcttc ttgttgctct tgtttccagg taccagatgt       60

gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt      120

ctcacttgtc gggcaagtca ggacattggt agtagcttaa actggcttca gcaggaacca      180

gatggaacta ttaaacgcct gatctacgcc acatccagtt tagattctgg tgtccccaaa      240

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      300

gaagattttg tagactatta ctgtctacaa tatgctagtt ctccgtacac gttcggaggg      360

gggaccaagc tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaag                                                              609


<210>  13
<211>  1530
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SCFV BASED ON MURINE

<400>  13
gatcaccggc gaaggagggc caccatggac cccaagggca gcctgagctg gagaatcctg       60

ctgttcctga gcctggcctt cgagctgagc tacggcgagg tgcagcttgt tgagtctggt      120

ggaggattgg tgcagcctaa aggatcattg aaactctcat gtgccgcctc tggtttcacc      180

ttcaatacct atgccatgca ctgggtccgc caggctccag gaaagggttt ggaatgggtt      240

gctcgcataa gaagtaaaag tagtaattat gcaacatatt atgccgattc agtgaaagac      300

agattcacca tctccagaga tgattcacaa agcatgctct atctgcaaat gaacaacctg      360

aaaactgagg acacagccat gtattactgt gtgagagata gaactgggtc ctggtttgct      420

tactggggcc aagggactct ggtcactgtc tctgcaggag gtggcggatc aggtggcgga      480

ggttctggcg gtggcggttc tgacatccag atgacccagt ctccatcctc cttatctgcc      540

tctctgggag aaagagtcag tctcacttgt cgggcaagtc aggacattgg tagtagctta      600

aactggcttc agcaggaacc agatggaact attaaacgcc tgatctacgc cacatccagt      660

ttagattctg gtgtccccaa aaggttcagt ggcagtaggt ctgggtcaga ttattctctc      720

accatcagca gccttgagtc tgaagatttt gtagactatt actgtctaca atatgctagt      780

tctccgtaca cgttcggagg ggggaccaag ctggaaataa aagacaagac ccacacctgc      840

cctccctgcc ccgcccccga gctgctgggc ggacccagcg tgttcctgtt ccctcccaag      900

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg      960

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac     1020

gccaagacca agcctcggga ggagcagtac aactccacct accgcgtggt gagcgtgctg     1080

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     1140

gccctgcccg ctcccatcga gaagaccatc agcaaggcca agggccagcc ccgggagcct     1200

caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt gagcctgacc     1260

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagag caacggccag     1320

cctgagaaca actacaagac cacccctccc gtgctggaca gcgatggcag cttcttcctg     1380

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1440

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccgga     1500

tagtgatccc agtgtcccta gctggccaga                                      1530


<210>  14
<211>  1530
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SCFV BASED ON MURINE

<400>  14
gatcaccggc gaaggagggc caccatggac cccaagggca gcctgagctg gagaatcctg       60

ctgttcctga gcctggcctt cgagctgagc tacggcgaca tccagatgac ccagtctcca      120

tcctccttat ctgcctctct gggagaaaga gtcagtctca cttgtcgggc aagtcaggac      180

attggtagta gcttaaactg gcttcagcag gaaccagatg gaactattaa acgcctgatc      240

tacgccacat ccagtttaga ttctggtgtc cccaaaaggt tcagtggcag taggtctggg      300

tcagattatt ctctcaccat cagcagcctt gagtctgaag attttgtaga ctattactgt      360

ctacaatatg ctagttctcc gtacacgttc ggagggggga ccaagctgga aataaaagga      420

ggtggcggat caggtggcgg aggttctggc ggtggcggtt ctgaggtgca gcttgttgag      480

tctggtggag gattggtgca gcctaaagga tcattgaaac tctcatgtgc cgcctctggt      540

ttcaccttca atacctatgc catgcactgg gtccgccagg ctccaggaaa gggtttggaa      600

tgggttgctc gcataagaag taaaagtagt aattatgcaa catattatgc cgattcagtg      660

aaagacagat tcaccatctc cagagatgat tcacaaagca tgctctatct gcaaatgaac      720

aacctgaaaa ctgaggacac agccatgtat tactgtgtga gagatagaac tgggtcctgg      780

tttgcttact ggggccaagg gactctggtc actgtctctg cagacaagac ccacacctgc      840

cctccctgcc ccgcccccga gctgctgggc ggacccagcg tgttcctgtt ccctcccaag      900

cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt ggtggacgtg      960

agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga ggtgcacaac     1020

gccaagacca agcctcggga ggagcagtac aactccacct accgcgtggt gagcgtgctg     1080

accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt gagcaacaag     1140

gccctgcccg ctcccatcga gaagaccatc agcaaggcca agggccagcc ccgggagcct     1200

caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt gagcctgacc     1260

tgcctggtga agggcttcta cccctccgac atcgccgtgg agtgggagag caacggccag     1320

cctgagaaca actacaagac cacccctccc gtgctggaca gcgatggcag cttcttcctg     1380

tacagcaagc tgaccgtgga caagtcccgg tggcagcagg gcaacgtgtt cagctgcagc     1440

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct gagccccgga     1500

tagtgatccc agtgtcccta gctggccaga                                      1530


<210>  15
<211>  1545
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SCFV BASED ON MURINE

<400>  15
gatcaccggc gaaggagggc caccatggac cccaagggca gcctgagctg gagaatcctg       60

ctgttcctga gcctggcctt cgagctgagc tacggcgagg tgcagcttgt tgagtctggt      120

ggaggattgg tgcagcctaa aggatcattg aaactctcat gtgccgcctc tggtttcacc      180

ttcaatacct atgccatgca ctgggtccgc caggctccag gaaagggttt ggaatgggtt      240

gctcgcataa gaagtaaaag tagtaattat gcaacatatt atgccgattc agtgaaagac      300

agattcacca tctccagaga tgattcacaa agcatgctct atctgcaaat gaacaacctg      360

aaaactgagg acacagccat gtattactgt gtgagagata gaactgggtc ctggtttgct      420

tactggggcc aagggactct ggtcactgtc tctgcaggct ctacaggagg tggcggatca      480

ggtaaacctg gttctggcga aggaggtggc ggttcagaca tccagatgac ccagtctcca      540

tcctccttat ctgcctctct gggagaaaga gtcagtctca cttgtcgggc aagtcaggac      600

attggtagta gcttaaactg gcttcagcag gaaccagatg gaactattaa acgcctgatc      660

tacgccacat ccagtttaga ttctggtgtc cccaaaaggt tcagtggcag taggtctggg      720

tcagattatt ctctcaccat cagcagcctt gagtctgaag attttgtaga ctattactgt      780

ctacaatatg ctagttctcc gtacacgttc ggagggggga ccaagctgga aataaaagac      840

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggacc cagcgtgttc      900

ctgttccctc ccaagcccaa ggacaccctg atgatcagcc gcacccccga ggtgacctgc      960

gtggtggtgg acgtgagcca cgaggacccc gaggtgaagt tcaactggta cgtggacggc     1020

gtggaggtgc acaacgccaa gaccaagcct cgggaggagc agtacaactc cacctaccgc     1080

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc     1140

aaggtgagca acaaggccct gcccgctccc atcgagaaga ccatcagcaa ggccaagggc     1200

cagccccggg agcctcaggt gtacaccctg ccccccagcc gcgacgagct gaccaagaac     1260

caggtgagcc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg     1320

gagagcaacg gccagcctga gaacaactac aagaccaccc ctcccgtgct ggacagcgat     1380

ggcagcttct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1440

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1500

agcctgagcc ccggatagtg atcccagtgt ccctagctgg ccaga                     1545


<210>  16
<211>  1545
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  SCFV BASED ON MURINE

<400>  16
gatcaccggc gaaggagggc caccatggac cccaagggca gcctgagctg gagaatcctg       60

ctgttcctga gcctggcctt cgagctgagc tacggcgaca tccagatgac ccagtctcca      120

tcctccttat ctgcctctct gggagaaaga gtcagtctca cttgtcgggc aagtcaggac      180

attggtagta gcttaaactg gcttcagcag gaaccagatg gaactattaa acgcctgatc      240

tacgccacat ccagtttaga ttctggtgtc cccaaaaggt tcagtggcag taggtctggg      300

tcagattatt ctctcaccat cagcagcctt gagtctgaag attttgtaga ctattactgt      360

ctacaatatg ctagttctcc gtacacgttc ggagggggga ccaagctgga aataaaaggc      420

tctacaggag gtggcggatc aggtaaacct ggttctggcg aaggaggtgg cggttcagag      480

gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aaggatcatt gaaactctca      540

tgtgccgcct ctggtttcac cttcaatacc tatgccatgc actgggtccg ccaggctcca      600

ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtagtaatta tgcaacatat      660

tatgccgatt cagtgaaaga cagattcacc atctccagag atgattcaca aagcatgctc      720

tatctgcaaa tgaacaacct gaaaactgag gacacagcca tgtattactg tgtgagagat      780

agaactgggt cctggtttgc ttactggggc caagggactc tggtcactgt ctctgcagac      840

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggacc cagcgtgttc      900

ctgttccctc ccaagcccaa ggacaccctg atgatcagcc gcacccccga ggtgacctgc      960

gtggtggtgg acgtgagcca cgaggacccc gaggtgaagt tcaactggta cgtggacggc     1020

gtggaggtgc acaacgccaa gaccaagcct cgggaggagc agtacaactc cacctaccgc     1080

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc     1140

aaggtgagca acaaggccct gcccgctccc atcgagaaga ccatcagcaa ggccaagggc     1200

cagccccggg agcctcaggt gtacaccctg ccccccagcc gcgacgagct gaccaagaac     1260

caggtgagcc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg     1320

gagagcaacg gccagcctga gaacaactac aagaccaccc ctcccgtgct ggacagcgat     1380

ggcagcttct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1440

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1500

agcctgagcc ccggatagtg atcccagtgt ccctagctgg ccaga                     1545


<210>  17
<211>  120
<212>  PRT
<213>  MURINE SP.

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Arg Thr Gly Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  18
<211>  107
<212>  PRT
<213>  MURINE SP.

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


