                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHOD FOR TREATING ASTHMA OR ALLERGIC DISEASE

<130> 701039-096930WOPT

<140> PCT/US2021/018174
<141> 2021-02-16

<150> 62/979,602
<151> 2020-02-21

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 16
<212> PRT
<213> Homo sapiens

<400> 1
Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys 
1               5                   10                  15      


<210> 2
<211> 927
<212> DNA
<213> Homo sapiens

<400> 2
atgcccgggc aagaactcag gacggtgaat ggctctcaga tgctcctggt gttgctggtg       60

ctctcgtggc tgccgcatgg gggcgccctg tctctggccg aggcgagccg cgcaagtttc      120

ccgggaccct cagagttgca ctccgaagac tccagattcc gagagttgcg gaaacgctac      180

gaggacctgc taaccaggct gcgggccaac cagagctggg aagattcgaa caccgacctc      240

gtcccggccc ctgcagtccg gatactcacg ccagaagtgc ggctgggatc cggcggccac      300

ctgcacctgc gtatctctcg ggccgccctt cccgaggggc tccccgaggc ctcccgcctt      360

caccgggctc tgttccggct gtccccgacg gcgtcaaggt cgtgggacgt gacacgaccg      420

ctgcggcgtc agctcagcct tgcaagaccc caggcgcccg cgctgcacct gcgactgtcg      480

ccgccgccgt cgcagtcgga ccaactgctg gcagaatctt cgtccgcacg gccccagctg      540

gagttgcact tgcggccgca agccgccagg gggcgccgca gagcgcgtgc gcgcaacggg      600

gaccactgtc cgctcgggcc cgggcgttgc tgccgtctgc acacggtccg cgcgtcgctg      660

gaagacctgg gctgggccga ttgggtgctg tcgccacggg aggtgcaagt gaccatgtgc      720

atcggcgcgt gcccgagcca gttccgggcg gcaaacatgc acgcgcagat caagacgagc      780

ctgcaccgcc tgaagcccga cacggtgcca gcgccctgct gcgtgcccgc cagctacaat      840

cccatggtgc tcattcaaaa gaccgacacc ggggtgtcgc tccagaccta tgatgacttg      900

ttagccaaag actgccactg catatga                                          927


<210> 3
<211> 5912
<212> DNA
<213> Homo sapiens

<400> 3
atgcagcccc cttcactgct gctgctgctg ctgctgctgc tgctgctatg tgtctcagtg       60

gtcagaccca gagggctgct gtgtgggagt ttcccagaac cctgtgccaa tggaggcacc      120

tgcctgagcc tgtctctggg acaagggacc tgccagtgtg cccctggctt cctgggtgag      180

acgtgccagt ttcctgaccc ctgccagaac gcccagctct gccaaaatgg aggcagctgc      240

caagccctgc ttcccgctcc cctagggctc cccagctctc cctctccatt gacacccagc      300

ttcttgtgca cttgcctccc tggcttcact ggtgagagat gccaggccaa gcttgaagac      360

ccttgtcctc cctccttctg ttccaaaagg ggccgctgcc acatccaggc ctcgggccgc      420

ccacagtgct cctgcatgcc tggatggaca ggtgagcagt gccagcttcg ggacttctgt      480

tcagccaacc catgtgttaa tggaggggtg tgtctggcca cataccccca gatccagtgc      540

cactgcccac cgggcttcga gggccatgcc tgtgaacgtg atgtcaacga gtgcttccag      600

gacccaggac cctgccccaa aggcacctcc tgccataaca ccctgggctc cttccagtgc      660

ctctgccctg tggggcagga gggtccacgt tgtgagctgc gggcaggacc ctgccctcct      720

aggggctgtt cgaatggggg cacctgccag ctgatgccag agaaagactc cacctttcac      780

ctctgcctct gtcccccagg tttcataggc ccagactgtg aggtgaatcc agacaactgt      840

gtcagccacc agtgtcagaa tgggggcact tgccaggatg ggctggacac ctacacctgc      900

ctctgcccag aaacctggac aggctgggac tgctccgaag atgtggatga gtgtgagacc      960

cagggtcccc ctcactgcag aaacgggggc acctgccaga actctgctgg tagctttcac     1020

tgcgtgtgtg tgagtggctg gggcggcaca agctgtgagg agaacctgga tgactgtatt     1080

gctgccacct gtgccccggg atccacctgc attgaccggg tgggctcttt ctcctgcctc     1140

tgcccacctg gacgcacagg actcctgtgc cacttggaag acatgtgtct gagccagccg     1200

tgccatgggg atgcccaatg cagcaccaac cccctcacag gctccacact ctgcctgtgt     1260

cagcctggct attcggggcc cacctgccac caggacctgg acgagtgtct gatggcccag     1320

caaggcccaa gtccctgtga acatggcggt tcctgcctca acactcctgg ctccttcaac     1380

tgcctctgtc cacctggcta cacaggctcc cgttgtgagg ctgatcacaa tgagtgcctc     1440

tcccagccct gccacccagg aagcacctgt ctggacctac ttgccacctt ccactgcctc     1500

tgcccgccag gcttagaagg gcagctctgt gaggtggaga ccaacgagtg tgcctcagct     1560

ccctgcctga accacgcgga ttgccatgac ctgctcaacg gcttccagtg catctgcctg     1620

cctggattct ccggcacccg atgtgaggag gatatcgatg agtgcagaag ctctccctgt     1680

gccaatggtg ggcagtgcca ggaccagcct ggagccttcc actgcaagtg tctcccaggc     1740

tttgaagggc cacgctgtca aacagaggtg gatgagtgcc tgagtgaccc atgtcccgtt     1800

ggagccagct gccttgatct tccaggagcc ttcttttgcc tctgcccctc tggtttcaca     1860

ggccagctct gtgaggttcc cctgtgtgct cccaacctgt gccagcccaa gcagatatgt     1920

aaggaccaga aagacaaggc caactgcctc tgtcctgatg gaagccctgg ctgtgcccca     1980

cctgaggaca actgcacctg ccaccacggg cactgccaga gatcctcatg tgtgtgtgac     2040

gtgggttgga cggggccaga gtgtgaggca gagctagggg gctgcatctc tgcaccctgt     2100

gcccatgggg ggacctgcta cccccagccc tctggctaca actgcacctg ccctacaggc     2160

tacacaggac ccacctgtag tgaggagatg acagcttgtc actcagggcc atgtctcaat     2220

ggcggctcct gcaaccctag ccctggaggc tactactgca cctgccctcc aagccacaca     2280

gggccccagt gccaaaccag cactgactac tgtgtgtctg ccccgtgctt caatgggggt     2340

acctgtgtga acaggcctgg caccttctcc tgcctctgtg ccatgggctt ccagggcccg     2400

cgctgtgagg gaaagctccg ccccagctgt gcagacagcc cctgtaggaa tagggcaacc     2460

tgccaggaca gccctcaggg tccccgctgc ctctgcccca ctggctacac cggaggcagc     2520

tgccagactc tgatggactt atgtgcccag aagccctgcc cacgcaattc ccactgcctc     2580

cagactgggc cctccttcca ctgcttgtgc ctccagggat ggaccgggcc tctctgcaac     2640

cttccactgt cctcctgcca gaaggctgca ctgagccaag gcatagacgt ctcttccctt     2700

tgccacaatg gaggcctctg tgtcgacagc ggcccctcct atttctgcca ctgcccccct     2760

ggattccaag gcagcctgtg ccaggatcac gtgaacccat gtgagtccag gccttgccag     2820

aacggggcca cctgcatggc ccagcccagt gggtatctct gccagtgtgc cccaggctac     2880

gatggacaga actgctcaaa ggaactcgat gcttgtcagt cccaaccctg tcacaaccat     2940

ggaacctgta ctcccaaacc tggaggattc cactgtgcct gccctccagg ctttgtgggg     3000

ctacgctgtg agggagacgt ggacgagtgt ctggaccagc cctgccaccc cacaggcact     3060

gcagcctgcc actctctggc caatgccttc tactgccagt gtctgcctgg acacacaggc     3120

cagtggtgtg aggtggagat agacccctgc cacagccaac cctgctttca tggagggacc     3180

tgtgaggcca cagcaggatc acccctgggt ttcatctgcc actgccccaa gggttttgaa     3240

ggccccacct gcagccacag ggccccttcc tgcggcttcc atcactgcca ccacggaggc     3300

ctgtgtctgc cctcccctaa gccaggcttc ccaccacgct gtgcctgcct cagtggctat     3360

gggggtcctg actgcctgac cccaccagct cctaaaggct gtggccctcc ctccccatgc     3420

ctatacaatg gcagctgctc agagaccacg ggcttggggg gcccaggctt tcgatgctcc     3480

tgccctcaca gctctccagg gccccggtgt cagaaacccg gagccaaggg gtgtgagggc     3540

agaagtggag atggggcctg cgatgctggc tgcagtggcc cgggaggaaa ctgggatgga     3600

ggggactgct ctctgggagt cccagacccc tggaagggct gcccctccca ctctcggtgc     3660

tggcttctct tccgggacgg gcagtgccac ccacagtgtg actctgaaga gtgtctgttt     3720

gatggctacg actgtgagac ccctccagcc tgcactccag cctatgacca gtactgccat     3780

gatcacttcc acaacgggca ctgtgagaaa ggctgcaaca ctgcagagtg tggctgggat     3840

ggaggtgact gcaggcctga agatggggac ccagagtggg ggccctccct ggccctgctg     3900

gtggtactga gccccccagc cctagaccag cagctgtttg ccctggcccg ggtgctgtcc     3960

ctgactctga gggtaggact ctgggtaagg aaggatcgtg atggcaggga catggtgtac     4020

ccctatcctg gggcccgggc tgaagaaaag ctaggaggaa ctcgggaccc cacctatcag     4080

gagagagcag cccctcaaac gcagcccctg ggcaaggaga ccgactccct cagtgctggg     4140

tttgtggtgg tcatgggtgt ggatttgtcc cgctgtggcc ctgaccaccc ggcatcccgc     4200

tgtccctggg accctgggct tctactccgc ttccttgctg cgatggctgc agtgggagcc     4260

ctggagcccc tgctgcctgg accactgctg gctgtccacc ctcatgcagg gaccgcaccc     4320

cctgccaacc agcttccctg gcctgtgctg tgctccccag tggccggggt gattctcctg     4380

gccctagggg ctcttctcgt cctccagctc atccggcgtc gacgccgaga gcatggagct     4440

ctctggctgc cccctggttt cactcgacgg cctcggactc agtcagctcc ccaccgacgc     4500

cggcccccac taggcgagga cagcattggt ctcaaggcac tgaagccaaa ggcagaagtt     4560

gatgaggatg gagttgtgat gtgctcaggc cctgaggagg gagaggaggt gggccaggct     4620

gaagaaacag gcccaccctc cacgtgccag ctctggtctc tgagtggtgg ctgtggggcg     4680

ctccctcagg cagccatgct aactcctccc caggaatctg agatggaagc ccctgacctg     4740

gacacccgtg gacctgatgg ggtgacaccc ctgatgtcag cagtttgctg tggggaagta     4800

cagtccggga ccttccaagg ggcatggttg ggatgtcctg agccctggga acctctgctg     4860

gatggagggg cctgtcccca ggctcacacc gtgggcactg gggagacccc cctgcacctg     4920

gctgcccgat tctcccggcc aaccgctgcc cgccgcctcc ttgaggctgg agccaacccc     4980

aaccagccag accgggcagg gcgcacaccc cttcatgctg ctgtggctgc tgatgctcgg     5040

gaggtctgcc agcttctgct ccgtagcaga caaactgcag tggacgctcg cacagaggac     5100

gggaccacac ccttgatgct ggctgccagg ctggcggtgg aagacctggt tgaagaactg     5160

attgcagccc aagcagacgt gggggccaga gataaatggg ggaaaactgc gctgcactgg     5220

gctgctgccg tgaacaacgc ccgagccgcc cgctcgcttc tccaggccgg agccgataaa     5280

gatgcccagg acaacaggga gcagacgccg ctattcctgg cggcgcggga aggagcggtg     5340

gaagtagccc agctactgct ggggctgggg gcagcccgag agctgcggga ccaggctggg     5400

ctagcgccgg cggacgtcgc tcaccaacgt aaccactggg atctgctgac gctgctggaa     5460

ggggctgggc caccagaggc ccgtcacaaa gccacgccgg gccgcgaggc tgggcccttc     5520

ccgcgcgcac ggacggtgtc agtaagcgtg cccccgcatg ggggcggggc tctgccgcgc     5580

tgccggacgc tgtcagccgg agcaggccct cgtgggggcg gagcttgtct gcaggctcgg     5640

acttggtccg tagacttggc tgcgcggggg ggcggggcct attctcattg ccggagcctc     5700

tcgggagtag gagcaggagg aggcccgacc cctcgcggcc gtaggttttc tgcaggcatg     5760

cgcgggcctc ggcccaaccc tgcgataatg cgaggaagat acggagtggc tgccgggcgc     5820

ggaggcaggg tctcaacgga tgactggccc tgtgattggg tggccctggg agcttgcggt     5880

tctgcctcca acattccgat cccgcctcct tg                                   5912


<210> 4
<211> 2003
<212> PRT
<213> Homo sapiens

<400> 4
Met Gln Pro Pro Ser Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Cys Val Ser Val Val Arg Pro Arg Gly Leu Leu Cys Gly Ser Phe Pro 
            20                  25                  30          


Glu Pro Cys Ala Asn Gly Gly Thr Cys Leu Ser Leu Ser Leu Gly Gln 
        35                  40                  45              


Gly Thr Cys Gln Cys Ala Pro Gly Phe Leu Gly Glu Thr Cys Gln Phe 
    50                  55                  60                  


Pro Asp Pro Cys Gln Asn Ala Gln Leu Cys Gln Asn Gly Gly Ser Cys 
65                  70                  75                  80  


Gln Ala Leu Leu Pro Ala Pro Leu Gly Leu Pro Ser Ser Pro Ser Pro 
                85                  90                  95      


Leu Thr Pro Ser Phe Leu Cys Thr Cys Leu Pro Gly Phe Thr Gly Glu 
            100                 105                 110         


Arg Cys Gln Ala Lys Leu Glu Asp Pro Cys Pro Pro Ser Phe Cys Ser 
        115                 120                 125             


Lys Arg Gly Arg Cys His Ile Gln Ala Ser Gly Arg Pro Gln Cys Ser 
    130                 135                 140                 


Cys Met Pro Gly Trp Thr Gly Glu Gln Cys Gln Leu Arg Asp Phe Cys 
145                 150                 155                 160 


Ser Ala Asn Pro Cys Val Asn Gly Gly Val Cys Leu Ala Thr Tyr Pro 
                165                 170                 175     


Gln Ile Gln Cys His Cys Pro Pro Gly Phe Glu Gly His Ala Cys Glu 
            180                 185                 190         


Arg Asp Val Asn Glu Cys Phe Gln Asp Pro Gly Pro Cys Pro Lys Gly 
        195                 200                 205             


Thr Ser Cys His Asn Thr Leu Gly Ser Phe Gln Cys Leu Cys Pro Val 
    210                 215                 220                 


Gly Gln Glu Gly Pro Arg Cys Glu Leu Arg Ala Gly Pro Cys Pro Pro 
225                 230                 235                 240 


Arg Gly Cys Ser Asn Gly Gly Thr Cys Gln Leu Met Pro Glu Lys Asp 
                245                 250                 255     


Ser Thr Phe His Leu Cys Leu Cys Pro Pro Gly Phe Ile Gly Pro Asp 
            260                 265                 270         


Cys Glu Val Asn Pro Asp Asn Cys Val Ser His Gln Cys Gln Asn Gly 
        275                 280                 285             


Gly Thr Cys Gln Asp Gly Leu Asp Thr Tyr Thr Cys Leu Cys Pro Glu 
    290                 295                 300                 


Thr Trp Thr Gly Trp Asp Cys Ser Glu Asp Val Asp Glu Cys Glu Thr 
305                 310                 315                 320 


Gln Gly Pro Pro His Cys Arg Asn Gly Gly Thr Cys Gln Asn Ser Ala 
                325                 330                 335     


Gly Ser Phe His Cys Val Cys Val Ser Gly Trp Gly Gly Thr Ser Cys 
            340                 345                 350         


Glu Glu Asn Leu Asp Asp Cys Ile Ala Ala Thr Cys Ala Pro Gly Ser 
        355                 360                 365             


Thr Cys Ile Asp Arg Val Gly Ser Phe Ser Cys Leu Cys Pro Pro Gly 
    370                 375                 380                 


Arg Thr Gly Leu Leu Cys His Leu Glu Asp Met Cys Leu Ser Gln Pro 
385                 390                 395                 400 


Cys His Gly Asp Ala Gln Cys Ser Thr Asn Pro Leu Thr Gly Ser Thr 
                405                 410                 415     


Leu Cys Leu Cys Gln Pro Gly Tyr Ser Gly Pro Thr Cys His Gln Asp 
            420                 425                 430         


Leu Asp Glu Cys Leu Met Ala Gln Gln Gly Pro Ser Pro Cys Glu His 
        435                 440                 445             


Gly Gly Ser Cys Leu Asn Thr Pro Gly Ser Phe Asn Cys Leu Cys Pro 
    450                 455                 460                 


Pro Gly Tyr Thr Gly Ser Arg Cys Glu Ala Asp His Asn Glu Cys Leu 
465                 470                 475                 480 


Ser Gln Pro Cys His Pro Gly Ser Thr Cys Leu Asp Leu Leu Ala Thr 
                485                 490                 495     


Phe His Cys Leu Cys Pro Pro Gly Leu Glu Gly Gln Leu Cys Glu Val 
            500                 505                 510         


Glu Thr Asn Glu Cys Ala Ser Ala Pro Cys Leu Asn His Ala Asp Cys 
        515                 520                 525             


His Asp Leu Leu Asn Gly Phe Gln Cys Ile Cys Leu Pro Gly Phe Ser 
    530                 535                 540                 


Gly Thr Arg Cys Glu Glu Asp Ile Asp Glu Cys Arg Ser Ser Pro Cys 
545                 550                 555                 560 


Ala Asn Gly Gly Gln Cys Gln Asp Gln Pro Gly Ala Phe His Cys Lys 
                565                 570                 575     


Cys Leu Pro Gly Phe Glu Gly Pro Arg Cys Gln Thr Glu Val Asp Glu 
            580                 585                 590         


Cys Leu Ser Asp Pro Cys Pro Val Gly Ala Ser Cys Leu Asp Leu Pro 
        595                 600                 605             


Gly Ala Phe Phe Cys Leu Cys Pro Ser Gly Phe Thr Gly Gln Leu Cys 
    610                 615                 620                 


Glu Val Pro Leu Cys Ala Pro Asn Leu Cys Gln Pro Lys Gln Ile Cys 
625                 630                 635                 640 


Lys Asp Gln Lys Asp Lys Ala Asn Cys Leu Cys Pro Asp Gly Ser Pro 
                645                 650                 655     


Gly Cys Ala Pro Pro Glu Asp Asn Cys Thr Cys His His Gly His Cys 
            660                 665                 670         


Gln Arg Ser Ser Cys Val Cys Asp Val Gly Trp Thr Gly Pro Glu Cys 
        675                 680                 685             


Glu Ala Glu Leu Gly Gly Cys Ile Ser Ala Pro Cys Ala His Gly Gly 
    690                 695                 700                 


Thr Cys Tyr Pro Gln Pro Ser Gly Tyr Asn Cys Thr Cys Pro Thr Gly 
705                 710                 715                 720 


Tyr Thr Gly Pro Thr Cys Ser Glu Glu Met Thr Ala Cys His Ser Gly 
                725                 730                 735     


Pro Cys Leu Asn Gly Gly Ser Cys Asn Pro Ser Pro Gly Gly Tyr Tyr 
            740                 745                 750         


Cys Thr Cys Pro Pro Ser His Thr Gly Pro Gln Cys Gln Thr Ser Thr 
        755                 760                 765             


Asp Tyr Cys Val Ser Ala Pro Cys Phe Asn Gly Gly Thr Cys Val Asn 
    770                 775                 780                 


Arg Pro Gly Thr Phe Ser Cys Leu Cys Ala Met Gly Phe Gln Gly Pro 
785                 790                 795                 800 


Arg Cys Glu Gly Lys Leu Arg Pro Ser Cys Ala Asp Ser Pro Cys Arg 
                805                 810                 815     


Asn Arg Ala Thr Cys Gln Asp Ser Pro Gln Gly Pro Arg Cys Leu Cys 
            820                 825                 830         


Pro Thr Gly Tyr Thr Gly Gly Ser Cys Gln Thr Leu Met Asp Leu Cys 
        835                 840                 845             


Ala Gln Lys Pro Cys Pro Arg Asn Ser His Cys Leu Gln Thr Gly Pro 
    850                 855                 860                 


Ser Phe His Cys Leu Cys Leu Gln Gly Trp Thr Gly Pro Leu Cys Asn 
865                 870                 875                 880 


Leu Pro Leu Ser Ser Cys Gln Lys Ala Ala Leu Ser Gln Gly Ile Asp 
                885                 890                 895     


Val Ser Ser Leu Cys His Asn Gly Gly Leu Cys Val Asp Ser Gly Pro 
            900                 905                 910         


Ser Tyr Phe Cys His Cys Pro Pro Gly Phe Gln Gly Ser Leu Cys Gln 
        915                 920                 925             


Asp His Val Asn Pro Cys Glu Ser Arg Pro Cys Gln Asn Gly Ala Thr 
    930                 935                 940                 


Cys Met Ala Gln Pro Ser Gly Tyr Leu Cys Gln Cys Ala Pro Gly Tyr 
945                 950                 955                 960 


Asp Gly Gln Asn Cys Ser Lys Glu Leu Asp Ala Cys Gln Ser Gln Pro 
                965                 970                 975     


Cys His Asn His Gly Thr Cys Thr Pro Lys Pro Gly Gly Phe His Cys 
            980                 985                 990         


Ala Cys Pro Pro Gly Phe Val Gly  Leu Arg Cys Glu Gly  Asp Val Asp 
        995                 1000                 1005             


Glu Cys  Leu Asp Gln Pro Cys  His Pro Thr Gly Thr  Ala Ala Cys 
    1010                 1015                 1020             


His Ser  Leu Ala Asn Ala Phe  Tyr Cys Gln Cys Leu  Pro Gly His 
    1025                 1030                 1035             


Thr Gly  Gln Trp Cys Glu Val  Glu Ile Asp Pro Cys  His Ser Gln 
    1040                 1045                 1050             


Pro Cys  Phe His Gly Gly Thr  Cys Glu Ala Thr Ala  Gly Ser Pro 
    1055                 1060                 1065             


Leu Gly  Phe Ile Cys His Cys  Pro Lys Gly Phe Glu  Gly Pro Thr 
    1070                 1075                 1080             


Cys Ser  His Arg Ala Pro Ser  Cys Gly Phe His His  Cys His His 
    1085                 1090                 1095             


Gly Gly  Leu Cys Leu Pro Ser  Pro Lys Pro Gly Phe  Pro Pro Arg 
    1100                 1105                 1110             


Cys Ala  Cys Leu Ser Gly Tyr  Gly Gly Pro Asp Cys  Leu Thr Pro 
    1115                 1120                 1125             


Pro Ala  Pro Lys Gly Cys Gly  Pro Pro Ser Pro Cys  Leu Tyr Asn 
    1130                 1135                 1140             


Gly Ser  Cys Ser Glu Thr Thr  Gly Leu Gly Gly Pro  Gly Phe Arg 
    1145                 1150                 1155             


Cys Ser  Cys Pro His Ser Ser  Pro Gly Pro Arg Cys  Gln Lys Pro 
    1160                 1165                 1170             


Gly Ala  Lys Gly Cys Glu Gly  Arg Ser Gly Asp Gly  Ala Cys Asp 
    1175                 1180                 1185             


Ala Gly  Cys Ser Gly Pro Gly  Gly Asn Trp Asp Gly  Gly Asp Cys 
    1190                 1195                 1200             


Ser Leu  Gly Val Pro Asp Pro  Trp Lys Gly Cys Pro  Ser His Ser 
    1205                 1210                 1215             


Arg Cys  Trp Leu Leu Phe Arg  Asp Gly Gln Cys His  Pro Gln Cys 
    1220                 1225                 1230             


Asp Ser  Glu Glu Cys Leu Phe  Asp Gly Tyr Asp Cys  Glu Thr Pro 
    1235                 1240                 1245             


Pro Ala  Cys Thr Pro Ala Tyr  Asp Gln Tyr Cys His  Asp His Phe 
    1250                 1255                 1260             


His Asn  Gly His Cys Glu Lys  Gly Cys Asn Thr Ala  Glu Cys Gly 
    1265                 1270                 1275             


Trp Asp  Gly Gly Asp Cys Arg  Pro Glu Asp Gly Asp  Pro Glu Trp 
    1280                 1285                 1290             


Gly Pro  Ser Leu Ala Leu Leu  Val Val Leu Ser Pro  Pro Ala Leu 
    1295                 1300                 1305             


Asp Gln  Gln Leu Phe Ala Leu  Ala Arg Val Leu Ser  Leu Thr Leu 
    1310                 1315                 1320             


Arg Val  Gly Leu Trp Val Arg  Lys Asp Arg Asp Gly  Arg Asp Met 
    1325                 1330                 1335             


Val Tyr  Pro Tyr Pro Gly Ala  Arg Ala Glu Glu Lys  Leu Gly Gly 
    1340                 1345                 1350             


Thr Arg  Asp Pro Thr Tyr Gln  Glu Arg Ala Ala Pro  Gln Thr Gln 
    1355                 1360                 1365             


Pro Leu  Gly Lys Glu Thr Asp  Ser Leu Ser Ala Gly  Phe Val Val 
    1370                 1375                 1380             


Val Met  Gly Val Asp Leu Ser  Arg Cys Gly Pro Asp  His Pro Ala 
    1385                 1390                 1395             


Ser Arg  Cys Pro Trp Asp Pro  Gly Leu Leu Leu Arg  Phe Leu Ala 
    1400                 1405                 1410             


Ala Met  Ala Ala Val Gly Ala  Leu Glu Pro Leu Leu  Pro Gly Pro 
    1415                 1420                 1425             


Leu Leu  Ala Val His Pro His  Ala Gly Thr Ala Pro  Pro Ala Asn 
    1430                 1435                 1440             


Gln Leu  Pro Trp Pro Val Leu  Cys Ser Pro Val Ala  Gly Val Ile 
    1445                 1450                 1455             


Leu Leu  Ala Leu Gly Ala Leu  Leu Val Leu Gln Leu  Ile Arg Arg 
    1460                 1465                 1470             


Arg Arg  Arg Glu His Gly Ala  Leu Trp Leu Pro Pro  Gly Phe Thr 
    1475                 1480                 1485             


Arg Arg  Pro Arg Thr Gln Ser  Ala Pro His Arg Arg  Arg Pro Pro 
    1490                 1495                 1500             


Leu Gly  Glu Asp Ser Ile Gly  Leu Lys Ala Leu Lys  Pro Lys Ala 
    1505                 1510                 1515             


Glu Val  Asp Glu Asp Gly Val  Val Met Cys Ser Gly  Pro Glu Glu 
    1520                 1525                 1530             


Gly Glu  Glu Val Gly Gln Ala  Glu Glu Thr Gly Pro  Pro Ser Thr 
    1535                 1540                 1545             


Cys Gln  Leu Trp Ser Leu Ser  Gly Gly Cys Gly Ala  Leu Pro Gln 
    1550                 1555                 1560             


Ala Ala  Met Leu Thr Pro Pro  Gln Glu Ser Glu Met  Glu Ala Pro 
    1565                 1570                 1575             


Asp Leu  Asp Thr Arg Gly Pro  Asp Gly Val Thr Pro  Leu Met Ser 
    1580                 1585                 1590             


Ala Val  Cys Cys Gly Glu Val  Gln Ser Gly Thr Phe  Gln Gly Ala 
    1595                 1600                 1605             


Trp Leu  Gly Cys Pro Glu Pro  Trp Glu Pro Leu Leu  Asp Gly Gly 
    1610                 1615                 1620             


Ala Cys  Pro Gln Ala His Thr  Val Gly Thr Gly Glu  Thr Pro Leu 
    1625                 1630                 1635             


His Leu  Ala Ala Arg Phe Ser  Arg Pro Thr Ala Ala  Arg Arg Leu 
    1640                 1645                 1650             


Leu Glu  Ala Gly Ala Asn Pro  Asn Gln Pro Asp Arg  Ala Gly Arg 
    1655                 1660                 1665             


Thr Pro  Leu His Ala Ala Val  Ala Ala Asp Ala Arg  Glu Val Cys 
    1670                 1675                 1680             


Gln Leu  Leu Leu Arg Ser Arg  Gln Thr Ala Val Asp  Ala Arg Thr 
    1685                 1690                 1695             


Glu Asp  Gly Thr Thr Pro Leu  Met Leu Ala Ala Arg  Leu Ala Val 
    1700                 1705                 1710             


Glu Asp  Leu Val Glu Glu Leu  Ile Ala Ala Gln Ala  Asp Val Gly 
    1715                 1720                 1725             


Ala Arg  Asp Lys Trp Gly Lys  Thr Ala Leu His Trp  Ala Ala Ala 
    1730                 1735                 1740             


Val Asn  Asn Ala Arg Ala Ala  Arg Ser Leu Leu Gln  Ala Gly Ala 
    1745                 1750                 1755             


Asp Lys  Asp Ala Gln Asp Asn  Arg Glu Gln Thr Pro  Leu Phe Leu 
    1760                 1765                 1770             


Ala Ala  Arg Glu Gly Ala Val  Glu Val Ala Gln Leu  Leu Leu Gly 
    1775                 1780                 1785             


Leu Gly  Ala Ala Arg Glu Leu  Arg Asp Gln Ala Gly  Leu Ala Pro 
    1790                 1795                 1800             


Ala Asp  Val Ala His Gln Arg  Asn His Trp Asp Leu  Leu Thr Leu 
    1805                 1810                 1815             


Leu Glu  Gly Ala Gly Pro Pro  Glu Ala Arg His Lys  Ala Thr Pro 
    1820                 1825                 1830             


Gly Arg  Glu Ala Gly Pro Phe  Pro Arg Ala Arg Thr  Val Ser Val 
    1835                 1840                 1845             


Ser Val  Pro Pro His Gly Gly  Gly Ala Leu Pro Arg  Cys Arg Thr 
    1850                 1855                 1860             


Leu Ser  Ala Gly Ala Gly Pro  Arg Gly Gly Gly Ala  Cys Leu Gln 
    1865                 1870                 1875             


Ala Arg  Thr Trp Ser Val Asp  Leu Ala Ala Arg Gly  Gly Gly Ala 
    1880                 1885                 1890             


Tyr Ser  His Cys Arg Ser Leu  Ser Gly Val Gly Ala  Gly Gly Gly 
    1895                 1900                 1905             


Pro Thr  Pro Arg Gly Arg Arg  Phe Ser Ala Gly Met  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Asn Pro Ala Ile Met  Arg Gly Arg Tyr Gly  Val Ala Ala 
    1925                 1930                 1935             


Gly Arg  Gly Gly Arg Val Ser  Thr Asp Asp Trp Pro  Cys Asp Trp 
    1940                 1945                 1950             


Val Ala  Leu Gly Ala Cys Gly  Ser Ala Ser Asn Ile  Pro Ile Pro 
    1955                 1960                 1965             


Pro Pro  Cys Leu Thr Pro Ser  Pro Glu Arg Gly Ser  Pro Gln Leu 
    1970                 1975                 1980             


Asp Cys  Gly Pro Pro Ala Leu  Gln Glu Met Pro Ile  Asn Gln Gly 
    1985                 1990                 1995             


Gly Glu  Gly Lys Lys 
    2000             


<210> 5
<211> 308
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


