                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
 
<120>  CHIMERIC SCAVENGER RECEPTORS TARGETED TO PHOSPHORYLATED TAU 
       (PTAU) AND USES THEREOF

<130>  UTFC.P1502WO

<140>  not yet known
<141>  2021-01-15

<150>  US 63/069,896
<151>  2020-08-25

<150>  US 62/977,626
<151>  2020-02-17

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(46)
<223>  FcyRIIb

<220>
<221>  MISC_FEATURE
<222>  (47)..(158)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (159)..(173)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (174)..(288)
<223>  VH domain

<220>
<221>  MISC_FEATURE
<222>  (289)..(302)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (303)..(606)
<223>  FcyRIIb

<400>  1

Asp Ile Ala Ser Val Asp Gly Pro Thr Met Gly Ile Leu Pro Phe Leu 
1               5                   10                  15      


Leu Ile Pro Met Glu Ser Asn Trp Thr Val His Val Phe Ser Arg Thr 
            20                  25                  30          


Leu Cys His Met Leu Leu Trp Thr Ala Val Leu Asn Leu Ala Asp Ile 
        35                  40                  45              


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
    50                  55                  60                  


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser His Gly 
65                  70                  75                  80  


Arg Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
                85                  90                  95      


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro Asp Arg 
            100                 105                 110         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
        115                 120                 125             


Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Thr Arg His 
    130                 135                 140                 


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                165                 170                 175     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
            180                 185                 190         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
        195                 200                 205             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile 
    210                 215                 220                 


Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Arg 
225                 230                 235                 240 


Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                245                 250                 255     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Tyr 
            260                 265                 270         


Tyr Ala Val Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        275                 280                 285             


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Ala Gly 
    290                 295                 300                 


Thr His Asp Leu Pro Lys Ala Val Val Lys Leu Glu Pro Pro Trp Ile 
305                 310                 315                 320 


Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly Thr His 
                325                 330                 335     


Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gly Arg Ser Ile 
            340                 345                 350         


Arg Ser Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val Asn Asp 
        355                 360                 365             


Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser Asp Pro 
    370                 375                 380                 


Val Asp Leu Gly Val Ile Ser Asp Ala Leu Leu Leu Gln Thr Pro Gln 
385                 390                 395                 400 


Leu Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys His Ser Ala 
                405                 410                 415     


Arg Asn Lys Leu Leu Asn Ala Ile Ser Phe Phe His Asn Glu Lys Ser 
            420                 425                 430         


Val Arg Tyr His Ala Tyr Ser Ser Asn Phe Ser Ile Pro Lys Ala Asn 
        435                 440                 445             


His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly Arg Thr 
    450                 455                 460                 


Leu His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Gly Thr Lys Ser 
465                 470                 475                 480 


Ser Arg Ser Leu Pro Val Leu Thr Ile Val Ala Ala Val Thr Gly Ile 
                485                 490                 495     


Ala Val Ala Ala Ile Val Ile Ile Leu Val Ser Leu Val Tyr Leu Lys 
            500                 505                 510         


Lys Lys Gln Val Pro Ala Leu Pro Gly Asn Pro Asp His Arg Glu Met 
        515                 520                 525             


Gly Glu Thr Leu Pro Glu Glu Val Gly Glu Tyr Arg Gln Pro Ser Gly 
    530                 535                 540                 


Gly Ser Val Pro Val Ser Pro Gly Pro Pro Ser Gly Leu Glu Pro Thr 
545                 550                 555                 560 


Ser Ser Ser Pro Tyr Asn Pro Pro Asp Leu Glu Glu Ala Ala Lys Thr 
                565                 570                 575     


Glu Ala Glu Asn Thr Ile Thr Tyr Ser Leu Leu Lys His Pro Glu Ala 
            580                 585                 590         


Leu Asp Glu Glu Thr Glu His Asp Tyr Gln Asn His Ile Asp His His 
        595                 600                 605             


His His His His 
    610         


<210>  2
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  signal peptide

<220>
<221>  MISC_FEATURE
<222>  (39)..(150)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (151)..(165)
<223>  Linker

<220>
<221>  MISC_FEATURE
<222>  (166)..(280)
<223>  VH domain

<220>
<221>  MISC_FEATURE
<222>  (281)..(294)
<223>  Hinge

<220>
<221>  MISC_FEATURE
<222>  (295)..(508)
<223>  CD163 SRCR 3+4

<220>
<221>  MISC_FEATURE
<222>  (509)..(1066)
<223>  CD163 cassette

<220>
<221>  MISC_FEATURE
<222>  (1067)..(1195)
<223>  TM + cytoplasmic domain

<400>  2

Met Gly Gly His Arg Met Val Leu Leu Gly Gly Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Lys Arg Phe Val His Leu Gly Phe Phe Val Val Ala Val Ser Ser 
            20                  25                  30          


Leu Leu Ser Ala Ser Ala Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
        35                  40                  45              


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
    50                  55                  60                  


Gln Ser Leu Val His Ser His Gly Arg Thr Tyr Leu His Trp Tyr Leu 
65                  70                  75                  80  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
                85                  90                  95      


Arg Phe Phe Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            100                 105                 110         


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
        115                 120                 125             


Tyr Phe Cys Ser Gln Thr Arg His Phe Pro Tyr Thr Phe Gly Gly Gly 
    130                 135                 140                 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                165                 170                 175     


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
            180                 185                 190         


Thr Phe Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
        195                 200                 205             


Gly Leu Glu Trp Ile Gly Asp Ile Asn Pro Asn Arg Gly Gly Thr Thr 
    210                 215                 220                 


Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser 
225                 230                 235                 240 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
                245                 250                 255     


Ala Val Tyr Tyr Cys Ala Ser Tyr Tyr Ala Val Gly Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys Lys 
        275                 280                 285             


Pro Cys Ile Cys Thr Val Glu Gly Ala Asp Leu Ser Leu Arg Leu Val 
    290                 295                 300                 


Asp Gly Val Ser Arg Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly 
305                 310                 315                 320 


Glu Trp Gly Thr Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Ser 
                325                 330                 335     


Val Val Cys Lys Gln Leu Gly Cys Pro Thr Ala Ile Ser Ala Ile Gly 
            340                 345                 350         


Arg Val Asn Ala Ser Glu Gly Ser Gly Gln Ile Trp Leu Asp Asn Ile 
        355                 360                 365             


Ser Cys Glu Gly His Glu Ala Thr Leu Trp Glu Cys Lys His Gln Glu 
    370                 375                 380                 


Trp Gly Lys His Tyr Cys His His Arg Glu Asp Ala Gly Val Thr Cys 
385                 390                 395                 400 


Ser Asp Gly Ala Asp Leu Glu Leu Arg Leu Val Gly Gly Gly Ser Arg 
                405                 410                 415     


Cys Ala Gly Ile Val Glu Val Glu Ile Gln Lys Leu Thr Gly Lys Met 
            420                 425                 430         


Cys Ser Arg Gly Trp Thr Leu Ala Asp Ala Asp Val Val Cys Arg Gln 
        435                 440                 445             


Leu Gly Cys Gly Ser Ala Leu Gln Thr Gln Ala Lys Ile Tyr Ser Lys 
    450                 455                 460                 


Thr Gly Ala Thr Asn Thr Trp Leu Phe Pro Gly Ser Cys Asn Gly Asn 
465                 470                 475                 480 


Glu Thr Thr Phe Trp Gln Cys Lys Asn Trp Gln Trp Gly Gly Leu Ser 
                485                 490                 495     


Cys Asp Asn Phe Glu Glu Ala Lys Val Thr Cys Ser Gly His Arg Glu 
            500                 505                 510         


Pro Arg Leu Val Gly Gly Glu Ile Pro Cys Ser Gly Arg Val Glu Val 
        515                 520                 525             


Lys His Gly Asp Val Trp Gly Ser Val Cys Asp Phe Asp Leu Ser Leu 
    530                 535                 540                 


Glu Ala Ala Ser Val Val Cys Arg Glu Leu Gln Cys Gly Thr Val Val 
545                 550                 555                 560 


Ser Ile Leu Gly Gly Ala His Phe Gly Glu Gly Ser Gly Gln Ile Trp 
                565                 570                 575     


Gly Glu Glu Phe Gln Cys Ser Gly Asp Glu Ser His Leu Ser Leu Cys 
            580                 585                 590         


Ser Val Ala Pro Pro Leu Asp Arg Thr Cys Thr His Ser Arg Asp Val 
        595                 600                 605             


Ser Val Val Cys Ser Arg Tyr Ile Asp Ile Arg Leu Ala Gly Gly Glu 
    610                 615                 620                 


Ser Ser Cys Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly 
625                 630                 635                 640 


Pro Leu Cys Ser Ser His Trp Asp Met Glu Asp Ala His Val Leu Cys 
                645                 650                 655     


Gln Gln Leu Lys Cys Gly Val Ala Gln Ser Ile Pro Glu Gly Ala His 
            660                 665                 670         


Phe Gly Lys Gly Ala Gly Gln Val Trp Ser His Met Phe His Cys Thr 
        675                 680                 685             


Gly Thr Glu Glu His Ile Gly Asp Cys Leu Met Thr Ala Leu Gly Ala 
    690                 695                 700                 


Pro Thr Cys Ser Glu Gly Gln Val Ala Ser Val Ile Cys Ser Gly Asn 
705                 710                 715                 720 


Gln Ser Gln Thr Leu Leu Pro Cys Ser Ser Leu Ser Pro Val Gln Thr 
                725                 730                 735     


Thr Ser Ser Thr Ile Pro Lys Glu Ser Glu Val Pro Cys Ile Ala Ser 
            740                 745                 750         


Gly Gln Leu Arg Leu Val Gly Gly Gly Gly Arg Cys Ala Gly Arg Val 
        755                 760                 765             


Glu Val Tyr His Glu Gly Ser Trp Gly Thr Val Cys Asp Asp Asn Trp 
    770                 775                 780                 


Asp Met Thr Asp Ala Asn Val Val Cys Lys Gln Leu Asp Cys Gly Val 
785                 790                 795                 800 


Ala Ile Asn Ala Thr Gly Ser Ala Tyr Phe Gly Glu Gly Ala Gly Ala 
                805                 810                 815     


Ile Trp Leu Asp Glu Val Ile Cys Thr Gly Lys Glu Ser His Ile Trp 
            820                 825                 830         


Gln Cys His Ser His Gly Trp Gly Arg His Asn Cys Arg His Lys Glu 
        835                 840                 845             


Asp Ala Gly Val Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Asn 
    850                 855                 860                 


Glu Ala His Lys Glu Asn Cys Thr Gly Arg Leu Glu Val Phe Tyr Asn 
865                 870                 875                 880 


Gly Thr Trp Gly Ser Ile Gly Ser Ser Asn Met Ser Pro Thr Thr Val 
                885                 890                 895     


Gly Val Val Cys Arg Gln Leu Gly Cys Ala Asp Asn Gly Thr Val Lys 
            900                 905                 910         


Pro Ile Pro Ser Asp Lys Thr Pro Ser Arg Pro Met Trp Val Asp Arg 
        915                 920                 925             


Val Gln Cys Pro Lys Gly Val Asp Thr Leu Trp Gln Cys Pro Ser Ser 
    930                 935                 940                 


Pro Trp Lys Gln Arg Gln Ala Ser Pro Ser Ser Gln Glu Ser Trp Ile 
945                 950                 955                 960 


Ile Cys Asp Asn Lys Ile Arg Leu Gln Glu Gly His Thr Asp Cys Ser 
                965                 970                 975     


Gly Arg Val Glu Ile Trp His Lys Gly Ser Trp Gly Thr Val Cys Asp 
            980                 985                 990         


Asp Ser Trp Asp Leu Asn Asp Ala  Lys Val Val Cys Lys  Gln Leu Gly 
        995                 1000                 1005             


Cys Gly  Gln Ala Val Lys Ala  Leu Lys Glu Ala Ala  Phe Gly Pro 
    1010                 1015                 1020             


Gly Thr  Gly Pro Ile Trp Leu  Asn Glu Ile Lys Cys  Arg Gly Asn 
    1025                 1030                 1035             


Glu Ser  Ser Leu Trp Asp Cys  Pro Ala Lys Pro Trp  Ser His Ser 
    1040                 1045                 1050             


Asp Cys  Gly His Lys Glu Asp  Ala Ser Ile Gln Cys  Leu Pro Lys 
    1055                 1060                 1065             


Met Thr  Ser Glu Ser His His  Gly Thr Gly His Pro  Thr Leu Thr 
    1070                 1075                 1080             


Ala Leu  Leu Val Cys Gly Ala  Ile Leu Leu Val Leu  Leu Ile Val 
    1085                 1090                 1095             


Phe Leu  Leu Trp Thr Leu Lys  Arg Arg Gln Ile Gln  Arg Leu Thr 
    1100                 1105                 1110             


Val Ser  Ser Arg Gly Glu Val  Leu Ile His Gln Val  Gln Tyr Gln 
    1115                 1120                 1125             


Glu Met  Asp Ser Lys Ala Asp  Asp Leu Asp Leu Leu  Lys Ser Ser 
    1130                 1135                 1140             


Glu Asn  Ser Asn Asn Ser Tyr  Asp Phe Asn Asp Asp  Gly Leu Thr 
    1145                 1150                 1155             


Ser Leu  Ser Lys Tyr Leu Pro  Ile Ser Gly Ile Lys  Lys Gly Ser 
    1160                 1165                 1170             


Phe Arg  Gly Thr Leu Arg Arg  Lys Met Ile Ile Tyr  Asn Pro Leu 
    1175                 1180                 1185             


Arg Leu  Glu Phe Lys Lys Pro  
    1190                 1195 


<210>  3
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(55)
<223>  cytoplasmic domain

<220>
<221>  MISC_FEATURE
<222>  (56)..(78)
<223>  transmembrane domain

<220>
<221>  MISC_FEATURE
<222>  (79)..(114)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (209)..(259)
<223>  coiled coil

<220>
<221>  MISC_FEATURE
<222>  (277)..(350)
<223>  collagen-like domain

<220>
<221>  MISC_FEATURE
<222>  (357)..(370)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (371)..(482)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (483)..(497)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (498)..(612)
<223>  VH domain

<400>  3

Met Thr Lys Glu Met Thr Glu Asn Gln Arg Leu Cys Pro His Glu Gln 
1               5                   10                  15      


Glu Asp Ala Asp Cys Ser Ser Glu Ser Val Lys Phe Asp Ala Arg Ser 
            20                  25                  30          


Met Thr Ala Ser Leu Pro His Ser Thr Lys Asn Gly Pro Ser Leu Gln 
        35                  40                  45              


Glu Lys Leu Lys Ser Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu 
    50                  55                  60                  


Val Phe Ala Val Leu Ile Pro Val Val Gly Ile Val Thr Ala Gln Leu 
65                  70                  75                  80  


Leu Asn Trp Glu Met Lys Asn Cys Leu Val Cys Ser Leu Asn Thr Ser 
                85                  90                  95      


Asp Thr Ser Gln Gly Pro Met Glu Lys Glu Asn Thr Ser Lys Val Glu 
            100                 105                 110         


Met Arg Phe Thr Ile Ile Met Glu His Met Lys Asp Met Glu Glu Arg 
        115                 120                 125             


Ile Glu Ser Ile Ser Asn Ser Lys Ala Asp Leu Ile Asp Thr Glu Arg 
    130                 135                 140                 


Phe Gln Asn Phe Ser Met Ala Thr Asp Gln Arg Leu Asn Asp Ile Leu 
145                 150                 155                 160 


Leu Gln Leu Asn Ser Leu Ile Ser Ser Val Gln Glu His Gly Asn Ser 
                165                 170                 175     


Leu Asp Ala Ile Ser Lys Ser Leu Gln Ser Leu Asn Met Thr Leu Leu 
            180                 185                 190         


Asp Val Gln Leu His Thr Glu Thr Leu Asn Val Arg Val Arg Glu Ser 
        195                 200                 205             


Thr Ala Lys Gln Gln Glu Asp Ile Ser Lys Leu Glu Glu Arg Val Tyr 
    210                 215                 220                 


Lys Val Ser Ala Glu Val Gln Ser Val Lys Glu Glu Gln Ala His Val 
225                 230                 235                 240 


Glu Gln Glu Val Lys Gln Glu Val Arg Val Leu Asn Asn Ile Thr Asn 
                245                 250                 255     


Asp Leu Arg Leu Lys Asp Trp Glu His Ser Gln Thr Leu Lys Asn Ile 
            260                 265                 270         


Thr Phe Ile Gln Gly Pro Pro Gly Pro Gln Gly Glu Lys Gly Asp Arg 
        275                 280                 285             


Gly Leu Thr Gly Gln Thr Gly Pro Pro Gly Ala Pro Gly Ile Arg Gly 
    290                 295                 300                 


Ile Pro Gly Val Lys Gly Asp Arg Gly Gln Ile Gly Phe Pro Gly Gly 
305                 310                 315                 320 


Arg Gly Asn Pro Gly Ala Pro Gly Lys Pro Gly Arg Ser Gly Ser Pro 
                325                 330                 335     


Gly Pro Lys Gly Gln Lys Gly Glu Lys Gly Ser Val Gly Gly Ser Thr 
            340                 345                 350         


Pro Leu Lys Thr Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
        355                 360                 365             


Thr Val Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr 
    370                 375                 380                 


Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
385                 390                 395                 400 


His Ser His Gly Arg Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                405                 410                 415     


Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly 
            420                 425                 430         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        435                 440                 445             


Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser 
    450                 455                 460                 


Gln Thr Arg His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu 
465                 470                 475                 480 


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            500                 505                 510         


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
        515                 520                 525             


Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    530                 535                 540                 


Ile Gly Asp Ile Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys 
545                 550                 555                 560 


Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala 
                565                 570                 575     


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            580                 585                 590         


Cys Ala Ser Tyr Tyr Ala Val Gly Tyr Trp Gly Gln Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser 
    610         


<210>  4
<211>  637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(38)
<223>  signal peptide

<220>
<221>  MISC_FEATURE
<222>  (39)..(150)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (151)..(165)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (166)..(280)
<223>  VH domain

<220>
<221>  MISC_FEATURE
<222>  (281)..(294)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (295)..(508)
<223>  CD163 SRCR 3+4

<220>
<221>  MISC_FEATURE
<222>  (509)..(637)
<223>  TM + cytoplasmic domain

<400>  4

Met Gly Gly His Arg Met Val Leu Leu Gly Gly Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Lys Arg Phe Val His Leu Gly Phe Phe Val Val Ala Val Ser Ser 
            20                  25                  30          


Leu Leu Ser Ala Ser Ala Asp Ile Val Met Thr Gln Thr Pro Leu Ser 
        35                  40                  45              


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
    50                  55                  60                  


Gln Ser Leu Val His Ser His Gly Arg Thr Tyr Leu His Trp Tyr Leu 
65                  70                  75                  80  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
                85                  90                  95      


Arg Phe Phe Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            100                 105                 110         


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
        115                 120                 125             


Tyr Phe Cys Ser Gln Thr Arg His Phe Pro Tyr Thr Phe Gly Gly Gly 
    130                 135                 140                 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
                165                 170                 175     


Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
            180                 185                 190         


Thr Phe Thr Asp Tyr Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln 
        195                 200                 205             


Gly Leu Glu Trp Ile Gly Asp Ile Asn Pro Asn Arg Gly Gly Thr Thr 
    210                 215                 220                 


Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser 
225                 230                 235                 240 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
                245                 250                 255     


Ala Val Tyr Tyr Cys Ala Ser Tyr Tyr Ala Val Gly Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser Val Pro Arg Asp Cys Gly Cys Lys 
        275                 280                 285             


Pro Cys Ile Cys Thr Val Glu Gly Ala Asp Leu Ser Leu Arg Leu Val 
    290                 295                 300                 


Asp Gly Val Ser Arg Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly 
305                 310                 315                 320 


Glu Trp Gly Thr Val Cys Asp Asp Asn Trp Asp Leu Arg Asp Ala Ser 
                325                 330                 335     


Val Val Cys Lys Gln Leu Gly Cys Pro Thr Ala Ile Ser Ala Ile Gly 
            340                 345                 350         


Arg Val Asn Ala Ser Glu Gly Ser Gly Gln Ile Trp Leu Asp Asn Ile 
        355                 360                 365             


Ser Cys Glu Gly His Glu Ala Thr Leu Trp Glu Cys Lys His Gln Glu 
    370                 375                 380                 


Trp Gly Lys His Tyr Cys His His Arg Glu Asp Ala Gly Val Thr Cys 
385                 390                 395                 400 


Ser Asp Gly Ala Asp Leu Glu Leu Arg Leu Val Gly Gly Gly Ser Arg 
                405                 410                 415     


Cys Ala Gly Ile Val Glu Val Glu Ile Gln Lys Leu Thr Gly Lys Met 
            420                 425                 430         


Cys Ser Arg Gly Trp Thr Leu Ala Asp Ala Asp Val Val Cys Arg Gln 
        435                 440                 445             


Leu Gly Cys Gly Ser Ala Leu Gln Thr Gln Ala Lys Ile Tyr Ser Lys 
    450                 455                 460                 


Thr Gly Ala Thr Asn Thr Trp Leu Phe Pro Gly Ser Cys Asn Gly Asn 
465                 470                 475                 480 


Glu Thr Thr Phe Trp Gln Cys Lys Asn Trp Gln Trp Gly Gly Leu Ser 
                485                 490                 495     


Cys Asp Asn Phe Glu Glu Ala Lys Val Thr Cys Ser Pro Lys Met Thr 
            500                 505                 510         


Ser Glu Ser His His Gly Thr Gly His Pro Thr Leu Thr Ala Leu Leu 
        515                 520                 525             


Val Cys Gly Ala Ile Leu Leu Val Leu Leu Ile Val Phe Leu Leu Trp 
    530                 535                 540                 


Thr Leu Lys Arg Arg Gln Ile Gln Arg Leu Thr Val Ser Ser Arg Gly 
545                 550                 555                 560 


Glu Val Leu Ile His Gln Val Gln Tyr Gln Glu Met Asp Ser Lys Ala 
                565                 570                 575     


Asp Asp Leu Asp Leu Leu Lys Ser Ser Glu Asn Ser Asn Asn Ser Tyr 
            580                 585                 590         


Asp Phe Asn Asp Asp Gly Leu Thr Ser Leu Ser Lys Tyr Leu Pro Ile 
        595                 600                 605             


Ser Gly Ile Lys Lys Gly Ser Phe Arg Gly Thr Leu Arg Arg Lys Met 
    610                 615                 620                 


Ile Ile Tyr Asn Pro Leu Arg Leu Glu Phe Lys Lys Pro 
625                 630                 635         


<210>  5
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(46)
<223>  FcyRIIb

<220>
<221>  MISC_FEATURE
<222>  (47)..(158)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (159)..(173)
<223>  Linker

<220>
<221>  MISC_FEATURE
<222>  (174)..(288)
<223>  VH domain

<220>
<221>  MISC_FEATURE
<222>  (289)..(302)
<223>  Hinge

<220>
<221>  MISC_FEATURE
<222>  (303)..(559)
<223>  FcyRIIb

<400>  5

Asp Ile Ala Ser Val Asp Gly Pro Thr Met Gly Ile Leu Pro Phe Leu 
1               5                   10                  15      


Leu Ile Pro Met Glu Ser Asn Trp Thr Val His Val Phe Ser Arg Thr 
            20                  25                  30          


Leu Cys His Met Leu Leu Trp Thr Ala Val Leu Asn Leu Ala Asp Ile 
        35                  40                  45              


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
    50                  55                  60                  


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser His Gly 
65                  70                  75                  80  


Arg Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
                85                  90                  95      


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro Asp Arg 
            100                 105                 110         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
        115                 120                 125             


Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Thr Arg His 
    130                 135                 140                 


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                165                 170                 175     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
            180                 185                 190         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
        195                 200                 205             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile 
    210                 215                 220                 


Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Arg 
225                 230                 235                 240 


Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                245                 250                 255     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Tyr 
            260                 265                 270         


Tyr Ala Val Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        275                 280                 285             


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Ala Gly 
    290                 295                 300                 


Thr His Asp Leu Pro Lys Ala Val Val Lys Leu Glu Pro Pro Trp Ile 
305                 310                 315                 320 


Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly Thr His 
                325                 330                 335     


Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gly Arg Ser Ile 
            340                 345                 350         


Arg Ser Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val Asn Asp 
        355                 360                 365             


Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser Asp Pro 
    370                 375                 380                 


Val Asp Leu Gly Val Ile Ser Asp Ala Leu Leu Leu Gln Thr Pro Gln 
385                 390                 395                 400 


Leu Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys His Ser Ala 
                405                 410                 415     


Arg Asn Lys Leu Leu Asn Ala Ile Ser Phe Phe His Asn Glu Lys Ser 
            420                 425                 430         


Val Arg Tyr His Ala Tyr Ser Ser Asn Phe Ser Ile Pro Lys Ala Asn 
        435                 440                 445             


His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly Arg Thr 
    450                 455                 460                 


Leu His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Gly Thr Lys Ser 
465                 470                 475                 480 


Ser Arg Ser Leu Pro Val Leu Thr Ile Val Ala Ala Val Thr Gly Ile 
                485                 490                 495     


Ala Val Ala Ala Ile Val Ile Ile Leu Val Ser Leu Val Tyr Leu Lys 
            500                 505                 510         


Lys Lys Gln Val Pro Asp Asn Pro Pro Asp Leu Glu Glu Ala Ala Lys 
        515                 520                 525             


Thr Glu Ala Glu Asn Thr Ile Thr Tyr Ser Leu Leu Lys His Pro Glu 
    530                 535                 540                 


Ala Leu Asp Glu Glu Thr Glu His Asp Tyr Gln Asn His Ile Asp His 
545                 550                 555                 560 


His His His His His 
                565 


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


His Gly Arg Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Arg His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Tyr Ala Val Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
1               5                   10                  


<210>  10
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Ala Leu Pro Gly Asn Pro Asp His Arg Glu Met Gly Glu Thr Leu Pro 
1               5                   10                  15      


Glu Glu Val Gly Glu Tyr Arg Gln Pro Ser Gly Gly Ser Val Pro Val 
            20                  25                  30          


Ser Pro Gly Pro Pro Ser Gly Leu Glu Pro Thr Ser Ser Ser Pro Tyr 
        35                  40                  45              


<210>  11
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(46)
<223>  FcgammaRIIb

<220>
<221>  MISC_FEATURE
<222>  (47)..(158)
<223>  VL domain

<220>
<221>  MISC_FEATURE
<222>  (159)..(173)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (174)..(288)
<223>  VH domain

<220>
<221>  MISC_FEATURE
<222>  (289)..(302)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (303)..(606)
<223>  FcgammaR11b

<400>  11

Asp Ile Ala Ser Val Asp Gly Pro Thr Met Gly Ile Leu Pro Phe Leu 
1               5                   10                  15      


Leu Ile Pro Met Glu Ser Asn Trp Thr Val His Val Phe Ser Arg Thr 
            20                  25                  30          


Leu Cys His Met Leu Leu Trp Thr Ala Val Leu Asn Leu Ala Asp Ile 
        35                  40                  45              


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
    50                  55                  60                  


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser His Gly 
65                  70                  75                  80  


Arg Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
                85                  90                  95      


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Phe Gly Val Pro Asp Arg 
            100                 105                 110         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
        115                 120                 125             


Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Thr Arg His 
    130                 135                 140                 


Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
                165                 170                 175     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
            180                 185                 190         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met Asn 
        195                 200                 205             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile 
    210                 215                 220                 


Asn Pro Asn Arg Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys Gly Arg 
225                 230                 235                 240 


Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                245                 250                 255     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Tyr 
            260                 265                 270         


Tyr Ala Val Gly Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        275                 280                 285             


Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Ala Gly 
    290                 295                 300                 


Thr His Asp Leu Pro Lys Ala Val Val Lys Leu Glu Pro Pro Trp Ile 
305                 310                 315                 320 


Gln Val Leu Lys Glu Asp Thr Val Thr Leu Thr Cys Glu Gly Thr His 
                325                 330                 335     


Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Gly Arg Ser Ile 
            340                 345                 350         


Arg Ser Gln Val Gln Ala Ser Tyr Thr Phe Lys Ala Thr Val Asn Asp 
        355                 360                 365             


Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser Asp Pro 
    370                 375                 380                 


Val Asp Leu Gly Val Ile Ser Asp Ala Leu Leu Leu Gln Thr Pro Gln 
385                 390                 395                 400 


Leu Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys His Ser Ala 
                405                 410                 415     


Arg Asn Lys Leu Leu Asn Ala Ile Ser Phe Phe His Asn Glu Lys Ser 
            420                 425                 430         


Val Arg Tyr His Ala Tyr Ser Ser Asn Phe Ser Ile Pro Lys Ala Asn 
        435                 440                 445             


His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly Arg Thr 
    450                 455                 460                 


Leu His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Gly Thr Lys Ser 
465                 470                 475                 480 


Ser Arg Ser Leu Pro Val Leu Thr Ile Val Ala Ala Val Thr Gly Ile 
                485                 490                 495     


Ala Val Ala Ala Ile Val Ile Ile Leu Val Ser Leu Val Tyr Leu Lys 
            500                 505                 510         


Lys Lys Gln Val Pro Asp Asn Pro Pro Asp Leu Glu Glu Ala Ala Lys 
        515                 520                 525             


Thr Glu Ala Glu Asn Thr Ile Thr Tyr Ser Leu Leu Lys His Pro Glu 
    530                 535                 540                 


Ala Leu Asp Glu Glu Thr Glu His Asp Tyr Gln Asn His Ile Ala Leu 
545                 550                 555                 560 


Pro Gly Asn Pro Asp His Arg Glu Met Gly Glu Thr Leu Pro Glu Glu 
                565                 570                 575     


Val Gly Glu Tyr Arg Gln Pro Ser Gly Gly Ser Val Pro Val Ser Pro 
            580                 585                 590         


Gly Pro Pro Ser Gly Leu Glu Pro Thr Ser Ser Ser Pro Tyr His His 
        595                 600                 605             


His His His His 
    610         


