                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
 
<120>  MULTIPLEXED IN VIVO DISEASE SENSING WITH NUCLEIC ACID-BARCODED 
       REPORTERS

<130>  M0656.70482WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/977,817
<151>  2020-02-18

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Pro Leu Gly Val Arg Gly Lys 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Phe Pro Arg Ser Gly Gly Gly 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Gly Ser Gly Arg Ser Ala Asn Ala Lys 
1               5                   10  


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Val Pro Arg Gly 
1               5   


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Pro Val Pro Leu Ser Leu Val Met 
1               5               


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro 
1               5                   10                  


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
tcatagttag cgtaacgatc                                                   20


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Lys Gly Gly Pro Leu Gly Val Arg Gly Lys Gly Gly Cys 
1               5                   10              


<210>  9
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
uaauuucuac uaaguguaga ucgucgccgu ccagcucgac c                           41


<210>  10
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  11
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
uaauuucuac uaaguguaga uccugggugu uccacagcug a                           41


<210>  12
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
uaauuucuac uaaguguaga uctgtgttta tccgctcaca a                           41


<210>  13
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
uaauuucuac uaaguguaga uugaaguaga uauggcagca c                           41


<210>  14
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
uaauuucuac uaaguguaga uacaauaugu gcuucuacac a                           41


<210>  15
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
tagcattcca cagacagccc tcatagttag cgtaacgatc taaagttttg tcgtc            55


<210>  16
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(55)
<223>  Phosphorothioate linkages

<400>  16
tagcattcca cagacagccc tcatagttag cgtaacgatc taaagttttg tcgtc            55


<210>  17
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
tagcattcca cagacagccc tcatagttag cgtaacgatc taaagttttg tcgtc            55


<210>  18
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gacgacaaaa ctttagatcg ttacgctaac tatgagggct gtctgtggaa tgcta            55


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  19
ggtcgagctg gacggcgacg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  20
tcatagttag cgtaacgatc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  21
tcagctgtgg aacacccagg                                                   20


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Phosphorothioate linkages

<400>  22
gagtaacaga catggaccat cag                                               23


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  23
ttgtgagcgg ataaacacag                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  24
gtgctgccat atctacttca                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  25
tgtgtagaag cacatattgt                                                   20


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Modified by Cyanine 5 dye

<400>  26
cytcatagtt agcgtaacga tc                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Modified by Cyanine 5 dye

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Phosphorothioate linkages

<400>  27
cytcatagtt agcgtaacga tc                                                22


<210>  28
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
cgtaacgatc                                                              10


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gttagcgtaa cgatc                                                        15


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
tcatagttag cgtaacgatc                                                   20


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
tcatagttag cgtaacgatc taaa                                              24


<210>  32
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
cagccctcat agttagcgta acgatc                                            26


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
cagccctcat agttagcgta acgatctaaa                                        30


<210>  34
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
gacagccctc atagttagcg taacgatcta aagt                                   34


<210>  35
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Phosphorothioate linkages

<400>  35
cgtaacgatc                                                              10


<210>  36
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Phosphorothioate linkages

<400>  36
gttagcgtaa cgatc                                                        15


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<400>  37
tcatagttag cgtaacgatc                                                   20


<210>  38
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  Phosphorothioate linkages

<400>  38
tcatagttag cgtaacgatc taaa                                              24


<210>  39
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  Phosphorothioate linkages

<400>  39
cagccctcat agttagcgta acgatc                                            26


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Phosphorothioate linkages

<400>  40
cagccctcat agttagcgta acgatctaaa                                        30


<210>  41
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Phosphorothioate linkages

<400>  41
gacagccctc atagttagcg taacgatcta aagt                                   34


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  42
ggtcgagctg gacggcgacg                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  43
tcatagttag cgtaacgatc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  44
tcagctgtgg aacacccagg                                                   20


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(23)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Modified by Dibenzocyclooctyne

<400>  45
gagtaacaga catggaccat cag                                               23


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  46
ttgtgagcgg ataaacacag                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  47
gtgctgccat atctacttca                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Dibenzocyclooctyne

<400>  48
tgtgtagaag cacatattgt                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Modified by Azide

<400>  49
tcatagttag cgtaacgatc                                                   20


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Modifed by azide side chain and photocleavable linker

<400>  50

Lys Gly Gly Pro Leu Gly Val Arg Gly Lys Gly Gly Cys 
1               5                   10              


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Modifed by azide side chain and photocleavable linker

<400>  51

Lys Gly Gly Phe Pro Arg Ser Gly Gly Cys 
1               5                   10  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Modifed by azide side chain and photocleavable linker

<400>  52

Lys Gly Gly Gly Ser Gly Arg Ser Ala Asn Ala Lys Gly Gly Cys 
1               5                   10                  15  


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Modifed by azide side chain and photocleavable linker

<400>  53

Lys Gly Gly Val Pro Arg Gly Gly Cys 
1               5                   


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (2)..(3)
<223>  Modifed by azide side chain and photocleavable linker

<400>  54

Lys Gly Pro Val Pro Leu Ser Leu Val Met Gly Gly Cys 
1               5                   10              


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (10)..(11)
<223>  Modifed by CPQ2 and PEG2

<400>  55

Gly Gly Pro Gln Gly Ile Trp Gly Gln Lys Gly Cys 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (10)..(11)
<223>  Modifed by CPQ2 and PEG2

<400>  56

Gly Gly Leu Val Pro Arg Gly Ser Gly Lys Gly Cys 
1               5                   10          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (9)..(10)
<223>  Modifed by CPQ2 and PEG2

<400>  57

Gly Gly Pro Val Gly Leu Ile Gly Lys Gly Cys 
1               5                   10      


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2 and PEG2

<400>  58

Gly Gly Pro Trp Gly Ile Trp Gly Gln Gly Lys Gly Cys 
1               5                   10              


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2 and PEG2

<400>  59

Gly Gly Pro Val Pro Leu Ser Leu Val Met Lys Gly Cys 
1               5                   10              


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (10)..(11)
<223>  Modifed by CPQ2 and PEG2

<400>  60

Gly Gly Pro Leu Gly Leu Arg Ser Trp Lys Gly Cys 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (10)..(11)
<223>  Modifed by CPQ2 and PEG2

<400>  61

Gly Gly Pro Leu Gly Val Arg Gly Lys Lys Gly Cys 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (3)..(4)
<223>  Modifed by pipecolic acid

<220>
<221>  SITE
<222>  (9)..(10)
<223>  Modifed by CPQ2 and PEG2

<400>  62

Gly Gly Phe Arg Ser Gly Gly Gly Lys Gly Cys 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (9)..(10)
<223>  Modifed by CPQ2 and PEG2

<400>  63

Gly Gly Phe Pro Arg Ser Gly Gly Gly Gly Cys 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (3)..(4)
<223>  Modifed by pipecolic acid

<220>
<221>  SITE
<222>  (9)..(10)
<223>  Modifed by CPQ2 and PEG2

<400>  64

Gly Gly Phe Lys Ser Gly Gly Gly Lys Gly Cys 
1               5                   10      


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (13)..(14)
<223>  Modifed by CPQ2 and PEG2

<400>  65

Gly Gly Gly Ser Gly Arg Ser Ala Asn Ala Lys Gly Lys Gly Cys 
1               5                   10                  15  


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2 and PEG2

<400>  66

Gly Ile Leu Ser Arg Ile Val Gly Gly Gly Lys Gly Cys 
1               5                   10              


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (8)..(9)
<223>  Modifed by CPQ2 and PEG2

<400>  67

Gly Gly Val Pro Arg Gly Gly Lys Gly Cys 
1               5                   10  


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2 and PEG2

<400>  68

Gly Ser Gly Ser Lys Ile Ile Gly Gly Gly Lys Gly Cys 
1               5                   10              


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2 and PEG2

<400>  69

Gly Pro Val Pro Leu Ser Leu Val Met Gly Lys Gly Cys 
1               5                   10              


<210>  70
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Modifed by N-terminal Fluorescein fluorophore

<220>
<221>  SITE
<222>  (11)..(12)
<223>  Modifed by CPQ2

<220>
<221>  SITE
<222>  (13)..(14)
<223>  Modifed by PEG2

<400>  70

Gly Gly Leu Gly Pro Lys Gly Gln Thr Gly Lys Lys Lys Cys 
1               5                   10                  


<210>  71
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Leu Asp Tyr 
            20                  25                  30          


Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly 
        35                  40                  45              


Val Leu Cys Ile Asp Ala Ser Asp Asp Ile Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Pro Ile Gly Leu Ser Ser Ser Cys Leu Leu Glu Tyr Asp 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
        115                 120                 125             


His His His His His His Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro 
    130                 135                 140                 


Ser Thr Pro Pro Gly Ser Gly Arg Ser Ala Asn Ala Lys Gly Gly Gly 
145                 150                 155                 160 


Ser Cys 
        


<210>  72
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Trp Thr Val Gly Asn Thr Ile Leu Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asp Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Arg Ser Arg Gly Tyr Val Leu Ser Val Leu Arg Ser 
            100                 105                 110         


Val Asp Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Gly Ser His His His His His His Ser Pro Ser Thr Pro Pro Thr Pro 
    130                 135                 140                 


Ser Pro Ser Thr Pro Pro Gly Ser Gly Arg Ser Ala Asn Ala Lys Gly 
145                 150                 155                 160 


Gly Gly Ser Cys 
                


<210>  73
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Ala Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile 
            20                  25                  30          


Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr 
        35                  40                  45              


Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn 
    50                  55                  60                  


Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser 
65                  70                  75                  80  


Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu 
                85                  90                  95      


Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly 
            100                 105                 110         


Ala Ala Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile 
        115                 120                 125             


Leu Pro Glu Ala Ala Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser 
    130                 135                 140                 


Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu 
145                 150                 155                 160 


Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys 
                165                 170                 175     


Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu 
            180                 185                 190         


Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu 
        195                 200                 205             


Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu 
    210                 215                 220                 


Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala 
225                 230                 235                 240 


Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu 
                245                 250                 255     


Asn Glu Tyr Ile Asn Leu Tyr Asn Ala Lys Thr Lys Gln Ala Leu Pro 
            260                 265                 270         


Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu 
        275                 280                 285             


Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val 
    290                 295                 300                 


Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys 
305                 310                 315                 320 


Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly 
                325                 330                 335     


Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile 
            340                 345                 350         


Phe Gly Glu Trp Asn Leu Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp 
        355                 360                 365             


Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp 
    370                 375                 380                 


Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln 
385                 390                 395                 400 


Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys 
                405                 410                 415     


Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser 
            420                 425                 430         


Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys 
        435                 440                 445             


Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val 
    450                 455                 460                 


Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu 
465                 470                 475                 480 


Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp 
                485                 490                 495     


Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val 
            500                 505                 510         


Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn 
        515                 520                 525             


Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg 
    530                 535                 540                 


Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp 
545                 550                 555                 560 


Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn 
                565                 570                 575     


Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys 
            580                 585                 590         


Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn 
        595                 600                 605             


Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys 
    610                 615                 620                 


Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe 
625                 630                 635                 640 


Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe 
                645                 650                 655     


Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg 
            660                 665                 670         


Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys 
        675                 680                 685             


Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln 
    690                 695                 700                 


Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu 
705                 710                 715                 720 


His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln 
                725                 730                 735     


Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu 
            740                 745                 750         


Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn 
        755                 760                 765             


Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val 
    770                 775                 780                 


Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro 
785                 790                 795                 800 


Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1025                 1030                 1035             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1040                 1045                 1050             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1055                 1060                 1065             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Ala Ala Ala Lys  Lys Asn Asn 
    1070                 1075                 1080             


Val Phe  Ala Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1085                 1090                 1095             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1100                 1105                 1110             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1115                 1120                 1125             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1130                 1135                 1140             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1145                 1150                 1155             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1160                 1165                 1170             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1205                 1210                 1215             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1220                 1225             


<210>  74
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
gaucguuacg cuaacuauga                                                   20


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Pro Gln Gly Ile Trp Gly Gln 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Leu Val Pro Arg Gly Ser Gly 
1               5           


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Pro Val Gly Leu Ile Gly 
1               5       


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Pro Trp Gly Ile Trp Gly Gln Gly 
1               5               


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Pro Leu Gly Val Arg Phe Lys 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(2)
<223>  Linked by pipecolic acid

<400>  80

Phe Arg Ser Gly Gly Gly 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(2)
<223>  Linked by pipecolic acid

<400>  81

Phe Lys Ser Gly Gly Gly 
1               5       


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Ile Leu Ser Arg Ile Val Gly Gly 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Ser Gly Ser Lys Ile Ile Gly Gly 
1               5               


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Gly Leu Gly Pro Lys Gly Gln Thr Gly 
1               5                   


<210>  85
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (22)..(41)
<223>  Phosphorothioate linkages

<400>  85
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  86
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (31)..(41)
<223>  Phosphorothioate linkages

<400>  86
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  87
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (37)..(41)
<223>  Phosphorothioate linkages

<400>  87
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  88
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (22)..(41)
<223>  2'-O-Methoxyethyl nucleotide

<400>  88
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  89
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (32)..(41)
<223>  2'-O-Methoxyethyl nucleotide

<400>  89
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  90
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  modified_base
<222>  (38)..(41)
<223>  2'-O-Methoxyethyl nucleotide

<400>  90
uaauuucuac uaaguguaga ugaucguuac gcuaacuaug a                           41


<210>  91
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  91
ggucgagcug gacggcgacg                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  92
ucauaguuag cguaacgauc                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  93
ucagcugugg aacacccagg                                                   20


<210>  94
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(19)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Phosphorothioate linkages

<220>
<221>  misc_feature
<222>  (19)..(23)
<223>  Phosphorothioate linkages

<400>  94
gaguaacaga cauggaccau cag                                               23


<210>  95
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  95
uugugagcgg auaaacacag                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  96
gugcugccau aucuacuuca                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Phosphorothioate linkages

<220>
<221>  modified_base
<222>  (7)..(16)
<223>  2'-O-Methoxyethyl nucleotide

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  Phosphorothioate linkages

<400>  97
uguguagaag cacauauugu                                                   20


