               SEQUENCE LISTING

<110> Medizinische Hochschule Hannover

<120> Viral particle based on AAV2 for gene therapy

<130> M1091PCT

<150> EP20158633.6
<151> 2020-02-20

<160> 62

<170> BiSSAP 1.3.6

<210> 1
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 1
Thr His Gly Thr Pro Ala Asp 
1               5           

<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 2
Gly Cys Gly Gly Ile Pro Glu 
1               5           

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 3
Gln His Glu Ala Leu Arg Cys 
1               5           

<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 4
Asp Val Pro Thr Thr Gly Ile 
1               5           

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 5
Asp Thr Arg Cys Pro Ser Ser 
1               5           

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 6
Ala Leu Leu Cys Arg His Asp 
1               5           

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 7
Gly Ser Leu Gln Ser Gly Glu 
1               5           

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 8
Asp Pro Pro Ser Ser Ser Ala 
1               5           

<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 9
Val Ser Ser Thr Ser Pro Arg 
1               5           

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 10
Val Ser Ser Thr Pro Pro Arg 
1               5           

<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 11
Asn Leu Pro Gly Ser Gly Asp 
1               5           

<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 12
Ala Pro Ser Glu Ser Pro Asn 
1               5           

<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 13
Gly Ile Glu Ile Gly Cys Ser 
1               5           

<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 14
Val Gly Pro Ser Arg Gly Ser 
1               5           

<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 15
Ser Asn Gly Asn Ala Cys Gly 
1               5           

<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 16
Ala Glu Arg Gln Pro Thr Gly 
1               5           

<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 17
Gly Gly Glu Leu Asp Cys Arg 
1               5           

<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 18
Ala Asn Tyr Ser Pro Pro Ala 
1               5           

<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 19
Thr Gly Ser Pro Cys Thr Ala 
1               5           

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 20
Met Arg Thr Gly Val Ser Val 
1               5           

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 21
Ser Asp Trp Thr Glu Asp Pro 
1               5           

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 22
Gly Ser Pro Gly Asp Ala Gly 
1               5           

<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 23
Gln Ser Ala Gly Leu Glu Cys 
1               5           

<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 24
Ser Gln Asn Ser Thr Ser Arg 
1               5           

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 25
Cys Pro Tyr Gln Pro Pro Gly 
1               5           

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 26
Ala Arg Asp Ser Gly His Thr 
1               5           

<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 27
Tyr Pro Pro Pro Cys Glu Ser 
1               5           

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 28
Ser Pro Gly Gln Ser Cys Trp 
1               5           

<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 29
Gly Asn Gly Ala Gly Ala His 
1               5           

<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 30
Gly Cys Ala Gly Gly Asn Tyr 
1               5           

<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 31
Val Gly Ser Thr Leu Pro Gln 
1               5           

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 32
Tyr Gly Ala Arg His Asp Gly 
1               5           

<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 33
Asp Cys Thr Pro Gly Ala Ser 
1               5           

<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 34
Cys Phe Pro Arg Pro Asp Glu 
1               5           

<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 35
Phe Asp Pro Gly Tyr Arg Ser 
1               5           

<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 36
Ala Asn His Gly Val Thr Arg 
1               5           

<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 37
Asp Ser Val Ser Leu Gly Ala 
1               5           

<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 38
Ala Gly Asn Gln Thr Arg Ser 
1               5           

<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 39
Gly Val Pro Gln Arg Pro Glu 
1               5           

<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 40
Glu Pro Ser Gly Ser Val Cys 
1               5           

<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 41
Glu Leu His Ser Pro Ser Ala 
1               5           

<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 42
Pro Asn Glu Gly Ala Gly Arg 
1               5           

<210> 43
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 43
Ser Gly Ser Pro Thr His Cys 
1               5           

<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 44
Met Pro Arg Cys Thr Glu Ala 
1               5           

<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 45
Thr Gly Ser Pro Tyr Thr Ala 
1               5           

<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 46
Asn Leu Thr Arg Pro Ala Leu 
1               5           

<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 47
Ser Pro Thr Arg Asp Pro Cys 
1               5           

<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 48
Tyr Ala Pro Ala Arg Ser Ser 
1               5           

<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 49
Val Pro Val Arg Pro Thr Ser 
1               5           

<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 50
Arg Val Gly His Gly Ser Ala 
1               5           

<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 51
Arg Ile Ser Thr Glu Gly Ala 
1               5           

<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 52
Gln Gln Thr Gly Gly Thr Arg 
1               5           

<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> inserted amino acid section

<400> 53
Asp Thr Met Pro Ser Gly Val 
1               5           

<210> 54
<211> 747
<212> PRT
<213> Artificial Sequence


<220> 
<221> CHAIN
<222> 1..587
<223> N-terminal section of native CAP

<220> 
<223> CAP protein with inserted amino acid section

<220> 
<221> CHAIN
<222> 588..590
<223> linker

<220> 
<221> CHAIN
<222> 591..597
<223> inserted amino acid sequence

<220> 
<221> CHAIN
<222> 598..599
<223> linker

<220> 
<221> CHAIN
<222> 600..747
<223> C-terminal section of CAP

<400> 54
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Ala Ser Ala Thr His 
            580                 585                 590         
Gly Thr Pro Ala Asp Ala Ala Arg Gln Ala Ala Thr Ala Asp Val Asn 
        595                 600                 605             
Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 
Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe 
625                 630                 635                 640 
His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
                645                 650                 655     
Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr 
            660                 665                 670         
Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             
Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 
Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val 
705                 710                 715                 720 
Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     
Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         

<210> 55
<211> 747
<212> PRT
<213> Artificial Sequence


<220> 
<221> CHAIN
<222> 1..587
<223> N-terminal section of native CAP

<220> 
<223> CAP with inserted amino acid section

<220> 
<221> CHAIN
<222> 588..590
<223> linker

<220> 
<221> CHAIN
<222> 591..597
<223> inserted amino acid sequence

<220> 
<221> CHAIN
<222> 598..599
<223> linker

<220> 
<221> CHAIN
<222> 600..747
<223> C-terminal section of CAP

<400> 55
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Ala Ser Ala Asn Leu 
            580                 585                 590         
Pro Gly Ser Gly Asp Ala Ala Arg Gln Ala Ala Thr Ala Asp Val Asn 
        595                 600                 605             
Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
    610                 615                 620                 
Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly His Phe 
625                 630                 635                 640 
His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro 
                645                 650                 655     
Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr 
            660                 665                 670         
Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly 
        675                 680                 685             
Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys 
    690                 695                 700                 
Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val 
705                 710                 715                 720 
Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg 
                725                 730                 735     
Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745         

<210> 56
<211> 735
<212> PRT
<213> Adeno-associated virus - 2


<220> 
<223> wild-type CAP protein

<400> 56
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          
Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 
Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     
Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         
Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     
Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         
Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             
Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 
Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 
Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     
Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         
Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             
Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 
Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 
Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     
Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         
Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             
Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 
Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 
Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     
Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         
Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             
Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 
Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 
Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     
Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         
Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             
Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 
Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 
His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     
Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         
Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             
Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 
Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 
Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 

<210> 57
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> forward primer in CAP gene

<400> 57
ggtacgacga cgattgcc                                                  18


<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> reverse primer CAP gene

<400> 58
atgtccgtcc gtgtgtgg                                                  18


<210> 59
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Ptbp2 forward primer

<400> 59
tctccattcc ctatgttcat gc                                             22


<210> 60
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Ptbp2 reverse primer

<400> 60
gttcccgcag aatggtgagg tg                                             22


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Ptbp2 binding probe

<400> 61
atgttcctcg gaccaacttg                                                20


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> comparative inserted amino acid section

<400> 62
Leu Pro Ser Arg Pro Ser Leu 
1               5           

