                         SEQUENCE LISTING

<110>  Aelin Therapeutics
       VIB VZW
       Katholieke Universiteit Leuven, K.U. Leuven R&D
 
<120>  Molecules targeting mutant RAS protein

<130>  AEL-006-PCT

<150>  EP 20158306.9
<151>  2020-02-19

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly 
1               5                   10      


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly 
1               5                   10                  


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ala Gly Val 
1               5                   10              


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ser Gly 
1               5                   10          


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ala Gly Val Gly 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ser Gly Val Gly 
1               5                   10                  


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ser Gly Val 
1               5                   10              


<210>  10
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Val Val Gly Ala Val 
1               5       


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Val Val Val Gly Ala Val 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Val Val Gly Ala Val Gly 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Val Val Val Gly Ala Val Gly Val Gly 
1               5                   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  14

Gly Ser Gly Ser 
1               


<210>  15
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  15

Lys Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  16
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  16

Lys Leu Val Val Val Gly Ala Val Lys Gly Ser Lys Leu Val Val Val 
1               5                   10                  15      


Gly Ala Val Lys 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  17

Lys Val Val Val Gly Ala Val Gly Lys Gly Ser Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Lys 
            20  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  18

Lys Val Val Val Gly Ala Val Gly Val Gly Lys Gly Ser Lys Val Val 
1               5                   10                  15      


Val Gly Ala Val Gly Val Gly Lys 
            20                  


<210>  19
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  20
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  21
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  22
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  23
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Ala Gly Gly Val 
1               5   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   


<210>  25
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  25

Leu Val Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala 
1               5                   10              


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Val Val Val Gly Ala Val Gly Val Gly 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Val Val Val Gly Ala Cys Gly Val Gly 
1               5                   10  


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Val Val Val Gly Ala Ala Gly Val Gly 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Val Val Val Gly Ala Ala Gly Val 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Val Val Val Gly Ala Ser Gly Val Gly 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Leu Val Val Val Gly Ala Ser Gly Val 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Val Val Val Gly Ala Ser Gly 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  34

Val Val Gly Ala Val Gly Val Gly 
1               5               


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  35

Val Gly Ala Val Gly Val Gly 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Val Val Val Gly Ala Val Gly Val 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Val Val Gly Ala Val Gly Val 
1               5               


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38

Val Val Gly Ala Val Gly Val 
1               5           


<210>  39
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  39

Val Gly Ala Val Gly Val 
1               5       


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Val Val Val Gly Ala Val Gly 
1               5               


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Val Gly Ala Val Gly 
1               5       


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Val Val Val Gly Ala Cys Gly Val Gly 
1               5                   


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Val Gly Ala Cys Gly Val Gly 
1               5               


<210>  44
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Gly Ala Cys Gly Val Gly 
1               5           


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Val Val Gly Ala Cys Gly Val 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Val Gly Ala Cys Gly Val 
1               5           


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  47

Val Gly Ala Cys Gly Val 
1               5       


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Val Val Val Gly Ala Cys Gly 
1               5               


<210>  49
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  49

Val Val Val Gly Ala Cys Gly 
1               5           


<210>  50
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  50

Lys Lys Lys Lys 
1               


<210>  51
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Val Val Val Gly Ala Cys 
1               5           


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Val Val Val Gly Ala Cys 
1               5       


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Val Val Val Gly Ala Ala Gly Val Gly 
1               5                   


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Val Val Gly Ala Ala Gly Val Gly 
1               5               


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  55

Val Gly Ala Ala Gly Val Gly 
1               5           


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Val Val Val Gly Ala Ala Gly Val 
1               5               


<210>  57
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Val Gly Ala Ala Gly Val 
1               5           


<210>  58
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Gly Ala Ala Gly Val 
1               5       


<210>  59
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  59

Leu Val Val Val Gly Ala Ala Gly 
1               5               


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Val Val Val Gly Ala Ala Gly 
1               5           


<210>  61
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  61

Val Val Gly Ala Ala Gly 
1               5       


<210>  62
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  62

Leu Val Val Val Gly Ala Ala 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  63

Val Val Val Gly Ala Ala 
1               5       


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Val Val Val Gly Ala Ser Gly Val Gly 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  65

Val Val Gly Ala Ser Gly Val Gly 
1               5               


<210>  66
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  66

Val Gly Ala Ser Gly Val Gly 
1               5           


<210>  67
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  67

Val Val Val Gly Ala Ser Gly Val 
1               5               


<210>  68
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  68

Val Val Gly Ala Ser Gly Val 
1               5           


<210>  69
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Gly Ala Ser Gly Val 
1               5       


<210>  70
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  70

Val Val Val Gly Ala Ser Gly 
1               5           


<210>  71
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  71

Val Val Gly Ala Ser Gly 
1               5       


<210>  72
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Val Val Val Gly Ala Ser 
1               5           


<210>  73
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  73

Val Val Val Gly Ala Ser 
1               5       


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FLAG tag

<400>  74

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  75
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Leu Thr Ile Gln Leu Ile 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  76

Gly Phe Leu Cys Val Phe Ala Ile Asn 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Val Leu Val Gly 
1               5   


<210>  78
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Phe Tyr Thr Leu Val 
1               5       


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Thr Glu Tyr Lys Leu Val Val Val Gly Ala 
1               5                   10  


<210>  80
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  80

Lys Leu Ser Val Phe Ala Ile Lys Gly Ser Lys Leu Ser Val Phe Ala 
1               5                   10                  15      


Ile Lys 
        


<210>  81
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  81

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Cys Val 
1               5                   10              


<210>  82
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  82

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Val Val Gly 
1               5                   10                  


<210>  83
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  83

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Ser 
1               5                   10          


<210>  84
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  84

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Cys Val Gly 
1               5                   10                  


<210>  85
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  85

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Ser Val Gly 
1               5                   10                  


<210>  86
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  86

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Ser Val 
1               5                   10              


<210>  87
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Gly Gly Val Gly 
1               5   


<210>  88
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  88

Val Gly Ala Gly Gly Val Gly Lys Ser 
1               5                   


<210>  89
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  89

Val Val Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu 
1               5                   10              


<210>  90
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  90

Leu Val Val Val Gly Ala Gly Val Val Gly 
1               5                   10  


<210>  91
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  91

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Cys Val Gly 
1               5                   10                  


<210>  92
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  92

Leu Val Val Val Gly Ala Gly Cys Val Gly 
1               5                   10  


<210>  93
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  93

Leu Val Val Val Gly Ala Gly Cys Val 
1               5                   


<210>  94
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  94

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Ser Val Gly 
1               5                   10                  


<210>  95
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  95

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Ser Val 
1               5                   10              


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Val Val Val Gly Ala Gly Ser Val Gly 
1               5                   10  


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  97

Leu Val Val Val Gly Ala Gly Ser Val 
1               5                   


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Leu Val Val Val Gly Ala Gly Ser 
1               5               


<210>  99
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  99

Val Val Val Gly Ala Gly Val 
1               5           


<210>  100
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  100

Leu Val Val Val Gly Ala Gly Val 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  101

Val Val Val Gly Ala Gly Val Val 
1               5               


<210>  102
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  102

Val Val Val Gly Ala Gly Val Val Gly 
1               5                   


<210>  103
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  103

Val Val Gly Ala Gly Val Val Gly 
1               5               


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  104

Val Gly Ala Gly Val Val Gly 
1               5           


<210>  105
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Ala Gly Val Val Gly 
1               5       


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Leu Val Val Val Gly Ala Gly Val Val 
1               5                   


<210>  107
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  107

Val Val Val Gly Ala Gly Val Val 
1               5               


<210>  108
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  108

Val Val Gly Ala Gly Val Val 
1               5           


<210>  109
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Gly Ala Gly Val Val 
1               5       


<210>  110
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  110

Val Val Gly Ala Gly Val 
1               5       


<210>  111
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  111

Val Gly Ala Gly Cys Val Gly 
1               5           


<210>  112
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  112

Gly Ala Gly Cys Val Gly 
1               5       


<210>  113
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  113

Val Val Val Gly Ala Gly Cys Val 
1               5               


<210>  114
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  114

Val Val Gly Ala Gly Cys Val 
1               5           


<210>  115
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  115

Val Gly Ala Gly Cys Val 
1               5       


<210>  116
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  116

Leu Val Val Val Gly Ala Gly Cys 
1               5               


<210>  117
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  117

Val Val Val Gly Ala Gly Cys 
1               5           


<210>  118
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  118

Val Val Gly Ala Gly Cys 
1               5       


<210>  119
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  119

Val Val Val Gly Ala Gly Ser Val Gly 
1               5                   


<210>  120
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  120

Val Val Gly Ala Gly Ser Val Gly 
1               5               


<210>  121
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  121

Val Gly Ala Gly Ser Val Gly 
1               5           


<210>  122
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  122

Gly Ala Gly Ser Val Gly 
1               5       


<210>  123
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  123

Val Val Val Gly Ala Gly Ser Val 
1               5               


<210>  124
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  124

Val Val Gly Ala Gly Ser Val 
1               5           


<210>  125
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  125

Val Gly Ala Gly Ser Val 
1               5       


<210>  126
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  126

Val Val Val Gly Ala Gly Ser 
1               5           


<210>  127
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  127

Val Val Gly Ala Gly Ser 
1               5       


<210>  128
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  128

Lys Val Val Val Gly Ala Gly Val Lys Gly Ser Lys Val Val Val Gly 
1               5                   10                  15      


Ala Gly Val Lys 
            20  


<210>  129
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  129

Lys Leu Val Val Val Gly Ala Gly Val Lys Gly Ser Lys Leu Val Val 
1               5                   10                  15      


Val Gly Ala Gly Val Lys 
            20          


<210>  130
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  130

Lys Val Val Val Gly Ala Gly Val Val Lys Gly Ser Lys Val Val Val 
1               5                   10                  15      


Gly Ala Gly Val Val Lys 
            20          


<210>  131
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  131

Lys Val Val Val Gly Ala Gly Val Val Gly Lys Gly Ser Lys Val Val 
1               5                   10                  15      


Val Gly Ala Gly Val Val Gly Lys 
            20                  


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  132

Thr Glu Tyr Lys Leu Val Val Val Gly Ala 
1               5                   10  


<210>  133
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  133

Arg Arg Arg Arg 
1               


<210>  134
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  134

Asp Asp Asp Asp 
1               


<210>  135
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  135

Glu Glu Glu Glu 
1               


<210>  136
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  136

Lys Arg Lys Arg 
1               


<210>  137
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  137

Lys Arg Arg Lys 
1               


<210>  138
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  138

Arg Lys Lys Arg 
1               


<210>  139
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  139

Asp Glu Asp Glu 
1               


<210>  140
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  140

Asp Glu Glu Asp 
1               


<210>  141
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Gatekeeper region

<400>  141

Glu Asp Asp Glu 
1               


<210>  142
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  142

Gly Gly Gly Gly 
1               


<210>  143
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  143

Ser Ser Ser Ser 
1               


<210>  144
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  144

Gly Gly Gly Ser 
1               


<210>  145
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  145

Gly Gly Ser Gly 
1               


<210>  146
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  146

Gly Ser Gly Gly 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  147

Ser Gly Gly Gly 
1               


<210>  148
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  148

Gly Gly Ser Ser 
1               


<210>  149
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  149

Gly Ser Ser Gly 
1               


<210>  150
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  150

Ser Ser Gly Gly 
1               


<210>  151
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  151

Ser Gly Ser Gly 
1               


<210>  152
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  152

Gly Ser Gly Ser Gly 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  153

Ser Gly Ser Gly Ser 
1               5   


<210>  154
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  154

Pro Pro Pro Pro 
1               


<210>  155
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  155

Leu Ser Val Phe Ala Ile 
1               5       


<210>  156
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D-lysine

<400>  156

Xaa Leu Ser Val Phe Ala Ile Lys Gly Ser Lys Leu Ser Val Phe Ala 
1               5                   10                  15      


Ile Xaa 
        


<210>  157
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D-lysine

<400>  157

Xaa Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Xaa 
        


<210>  158
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D-lysine

<400>  158

Xaa Val Val Val Gly Ala Val Gly Lys Gly Ser Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Xaa 
            20  


<210>  159
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  D-lysine

<400>  159

Xaa Val Val Val Gly Ala Val Gly Val Gly Lys Gly Ser Lys Val Val 
1               5                   10                  15      


Val Gly Ala Val Gly Val Gly Xaa 
            20                  


<210>  160
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dpm

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Dpm

<400>  160

Xaa Leu Ser Val Phe Ala Ile Lys Gly Ser Lys Leu Ser Val Phe Ala 
1               5                   10                  15      


Ile Xaa 
        


<210>  161
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dpm

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Dpm

<400>  161

Xaa Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Xaa 
        


<210>  162
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dpm

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Dpm

<400>  162

Xaa Val Val Val Gly Ala Val Gly Lys Gly Ser Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Xaa 
            20  


<210>  163
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Dpm

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Dpm

<400>  163

Xaa Val Val Val Gly Ala Val Gly Val Gly Lys Gly Ser Lys Val Val 
1               5                   10                  15      


Val Gly Ala Val Gly Val Gly Xaa 
            20                  


<210>  164
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  citrulline

<400>  164

Xaa Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  165
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  citrulline

<400>  165

Lys Val Val Val Gly Ala Val Xaa Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  166
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  166

Ala Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  167
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  167

Lys Val Val Val Gly Ala Val Ala Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  168
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  168

Lys Val Val Val Gly Ala Val Lys Gly Ser Ala Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  169
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  169

Lys Val Val Val Gly Ala Val Lys Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Ala 
        


<210>  170
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  170

Ala Val Val Val Gly Ala Val Lys Gly Ser Ala Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  171
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  171

Lys Val Val Val Gly Ala Val Ala Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Ala 
        


<210>  172
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  172

Ala Val Val Val Gly Ala Val Ala Gly Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  173
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  173

Lys Val Val Val Gly Ala Val Lys Ala Ser Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  174
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  174

Lys Val Val Val Gly Ala Val Lys Gly Ala Lys Val Val Val Gly Ala 
1               5                   10                  15      


Val Lys 
        


<210>  175
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  175

Lys Val Val Val Gly Ala Val Gly Lys Gly Phe Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Lys 
            20  


<210>  176
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  176

Lys Val Val Val Gly Ala Val Gly Lys Phe Phe Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Lys 
            20  


<210>  177
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  177

Lys Leu Ser Val Phe Ala Ile Lys Lys Leu Ser Val Phe Ala Ile Lys 
1               5                   10                  15      


<210>  178
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in

<400>  178

Lys Val Val Val Gly Ala Val Gly Val Gly Lys Lys Val Val Val Gly 
1               5                   10                  15      


Ala Val Gly Val Gly Lys 
            20          


<210>  179
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-leucine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-serine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-isoleucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  D-serine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-leucine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  D-serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  D-isoleucine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D-lysine

<400>  179

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  180
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  D-serine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  D-lysine

<400>  180

Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  181
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RAS pept-in


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  D-serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  D-lysine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  D-alanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  D-valine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  D-lysine

<400>  181

Xaa Xaa Xaa Xaa Gly Xaa Xaa Gly Xaa Gly Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Xaa Xaa Gly Xaa Gly Xaa 
            20                  


<210>  182
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide

<400>  182

Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  183
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide

<400>  183

Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu Thr 
1               5                   10                  15      


Ile 
    


<210>  184
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  peptide

<400>  184

Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10              


