                         SEQUENCE LISTING

<110>  Vestlandets Innovasjonsselskap AS
 
<120>  TREATMENT OF CORNEAL VASCULARISATION

<130>  489.145590/03

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1106
<212>  PRT
<213>  Wild-type PDGFR (Homo sapiens)

<400>  1

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  2
<211>  5700
<212>  DNA
<213>  Wild-type PDGFR (Homo sapiens)

<400>  2
agcagccagc agtgactgcc cgccctatct gggacccagg atcgctctgt gagcaacttg       60

gagccagaga ggagatcaac aaggaggagg agagagccgg cccctcagcc ctgctgccca      120

gcagcagcct gtgctcgccc tgcccaacgc agacagccag acccagggcg gcccctctgg      180

cggctctgct cctcccgaag gatgcttggg gagtgaggcg aagctgggcc gctcctctcc      240

cctacagcag cccccttcct ccatccctct gttctcctga gccttcagga gcctgcacca      300

gtcctgcctg tccttctact cagctgttac ccactctggg accagcagtc tttctgataa      360

ctgggagagg gcagtaagga ggacttcctg gagggggtga ctgtccagag cctggaactg      420

tgcccacacc agaagccatc agcagcaagg acaccatgcg gcttccgggt gcgatgccag      480

ctctggccct caaaggcgag ctgctgttgc tgtctctcct gttacttctg gaaccacaga      540

tctctcaggg cctggtcgtc acacccccgg ggccagagct tgtcctcaat gtctccagca      600

ccttcgttct gacctgctcg ggttcagctc cggtggtgtg ggaacggatg tcccaggagc      660

ccccacagga aatggccaag gcccaggatg gcaccttctc cagcgtgctc acactgacca      720

acctcactgg gctagacacg ggagaatact tttgcaccca caatgactcc cgtggactgg      780

agaccgatga gcggaaacgg ctctacatct ttgtgccaga tcccaccgtg ggcttcctcc      840

ctaatgatgc cgaggaacta ttcatctttc tcacggaaat aactgagatc accattccat      900

gccgagtaac agacccacag ctggtggtga cactgcacga gaagaaaggg gacgttgcac      960

tgcctgtccc ctatgatcac caacgtggct tttctggtat ctttgaggac agaagctaca     1020

tctgcaaaac caccattggg gacagggagg tggattctga tgcctactat gtctacagac     1080

tccaggtgtc atccatcaac gtctctgtga acgcagtgca gactgtggtc cgccagggtg     1140

agaacatcac cctcatgtgc attgtgatcg ggaatgaggt ggtcaacttc gagtggacat     1200

acccccgcaa agaaagtggg cggctggtgg agccggtgac tgacttcctc ttggatatgc     1260

cttaccacat ccgctccatc ctgcacatcc ccagtgccga gttagaagac tcggggacct     1320

acacctgcaa tgtgacggag agtgtgaatg accatcagga tgaaaaggcc atcaacatca     1380

ccgtggttga gagcggctac gtgcggctcc tgggagaggt gggcacacta caatttgctg     1440

agctgcatcg gagccggaca ctgcaggtag tgttcgaggc ctacccaccg cccactgtcc     1500

tgtggttcaa agacaaccgc accctgggcg actccagcgc tggcgaaatc gccctgtcca     1560

cgcgcaacgt gtcggagacc cggtatgtgt cagagctgac actggttcgc gtgaaggtgg     1620

cagaggctgg ccactacacc atgcgggcct tccatgagga tgctgaggtc cagctctcct     1680

tccagctaca gatcaatgtc cctgtccgag tgctggagct aagtgagagc caccctgaca     1740

gtggggaaca gacagtccgc tgtcgtggcc ggggcatgcc ccagccgaac atcatctggt     1800

ctgcctgcag agacctcaaa aggtgtccac gtgagctgcc gcccacgctg ctggggaaca     1860

gttccgaaga ggagagccag ctggagacta acgtgacgta ctgggaggag gagcaggagt     1920

ttgaggtggt gagcacactg cgtctgcagc acgtggatcg gccactgtcg gtgcgctgca     1980

cgctgcgcaa cgctgtgggc caggacacgc aggaggtcat cgtggtgcca cactccttgc     2040

cctttaaggt ggtggtgatc tcagccatcc tggccctggt ggtgctcacc atcatctccc     2100

ttatcatcct catcatgctt tggcagaaga agccacgtta cgagatccga tggaaggtga     2160

ttgagtctgt gagctctgac ggccatgagt acatctacgt ggaccccatg cagctgccct     2220

atgactccac gtgggagctg ccgcgggacc agcttgtgct gggacgcacc ctcggctctg     2280

gggcctttgg gcaggtggtg gaggccacgg ctcatggcct gagccattct caggccacga     2340

tgaaagtggc cgtcaagatg cttaaatcca cagcccgcag cagtgagaag caagccctta     2400

tgtcggagct gaagatcatg agtcaccttg ggccccacct gaacgtggtc aacctgttgg     2460

gggcctgcac caaaggagga cccatctata tcatcactga gtactgccgc tacggagacc     2520

tggtggacta cctgcaccgc aacaaacaca ccttcctgca gcaccactcc gacaagcgcc     2580

gcccgcccag cgcggagctc tacagcaatg ctctgcccgt tgggctcccc ctgcccagcc     2640

atgtgtcctt gaccggggag agcgacggtg gctacatgga catgagcaag gacgagtcgg     2700

tggactatgt gcccatgctg gacatgaaag gagacgtcaa atatgcagac atcgagtcct     2760

ccaactacat ggccccttac gataactacg ttccctctgc ccctgagagg acctgccgag     2820

caactttgat caacgagtct ccagtgctaa gctacatgga cctcgtgggc ttcagctacc     2880

aggtggccaa tggcatggag tttctggcct ccaagaactg cgtccacaga gacctggcgg     2940

ctaggaacgt gctcatctgt gaaggcaagc tggtcaagat ctgtgacttt ggcctggctc     3000

gagacatcat gcgggactcg aattacatct ccaaaggcag cacctttttg cctttaaagt     3060

ggatggctcc ggagagcatc ttcaacagcc tctacaccac cctgagcgac gtgtggtcct     3120

tcgggatcct gctctgggag atcttcacct tgggtggcac cccttaccca gagctgccca     3180

tgaacgagca gttctacaat gccatcaaac ggggttaccg catggcccag cctgcccatg     3240

cctccgacga gatctatgag atcatgcaga agtgctggga agagaagttt gagattcggc     3300

cccccttctc ccagctggtg ctgcttctcg agagactgtt gggcgaaggt tacaaaaaga     3360

agtaccagca ggtggatgag gagtttctga ggagtgacca cccagccatc cttcggtccc     3420

aggcccgctt gcctgggttc catggcctcc gatctcccct ggacaccagc tccgtcctct     3480

atactgccgt gcagcccaat gagggtgaca acgactatat catccccctg cctgacccca     3540

aacccgaggt tgctgacgag ggcccactgg agggttcccc cagcctagcc agctccaccc     3600

tgaatgaagt caacacctcc tcaaccatct cctgtgacag ccccctggag ccccaggacg     3660

aaccagagcc agagccccag cttgagctcc aggtggagcc ggagccagag ctggaacagt     3720

tgccggattc ggggtgccct gcgcctcggg cggaagcaga ggatagcttc ctgtaggggg     3780

ctggccccta ccctgccctg cctgaagctc cccccctgcc agcacccagc atctcctggc     3840

ctggcctgac cgggcttcct gtcagccagg ctgcccttat cagctgtccc cttctggaag     3900

ctttctgctc ctgacgtgtt gtgccccaaa ccctggggct ggcttaggag gcaagaaaac     3960

tgcaggggcc gtgaccagcc ctctgcctcc agggaggcca actgactctg agccagggtt     4020

cccccaggga actcagtttt cccatatgta aaatgggaaa gttaggcttg atgacccaga     4080

atctaggatt ctctccctgg ctgacaggtg gggagaccga atccctccct gggaagattc     4140

ttggagttac tgaggtggta aattaacttt tttctgttca gccagctacc cctcaaggaa     4200

tcatagctct ctcctcgcac ttttatccac ccaggagcta gggaagagac cctagcctcc     4260

ctggctgctg gctgagctag ggcctagcct tgagcagtgt tgcctcatcc agaagaaagc     4320

cagtctcctc cctatgatgc cagtccctgc gttccctggc ccgagctggt ctggggccat     4380

taggcagcct aattaatgct ggaggctgag ccaagtacag gacaccccca gcctgcagcc     4440

cttgcccagg gcacttggag cacacgcagc catagcaagt gcctgtgtcc ctgtccttca     4500

ggcccatcag tcctggggct ttttctttat caccctcagt cttaatccat ccaccagagt     4560

ctagaaggcc agacgggccc cgcatctgtg atgagaatgt aaatgtgcca gtgtggagtg     4620

gccacgtgtg tgtgccagta tatggccctg gctctgcatt ggacctgcta tgaggctttg     4680

gaggaatccc tcaccctctc tgggcctcag tttccccttc aaaaaatgaa taagtcggac     4740

ttattaactc tgagtgcctt gccagcacta acattctaga gtattccagg tggttgcaca     4800

tttgtccaga tgaagcaagg ccatataccc taaacttcca tcctgggggt cagctgggct     4860

cctgggagat tccagatcac acatcacact ctggggactc aggaaccatg ccccttcccc     4920

aggcccccag caagtctcaa gaacacagct gcacaggcct tgacttagag tgacagccgg     4980

tgtcctggaa agcccccagc agctgcccca gggacatggg aagaccacgg gacctctttc     5040

actacccacg atgacctccg ggggtatcct gggcaaaagg gacaaagagg gcaaatgaga     5100

tcacctcctg cagcccacca ctccagcacc tgtgccgagg tctgcgtcga agacagaatg     5160

gacagtgagg acagttatgt cttgtaaaag acaagaagct tcagatgggt accccaagaa     5220

ggatgtgaga ggtgggcgct ttggaggttt gcccctcacc caccagctgc cccatccctg     5280

aggcagcgct ccatgggggt atggttttgt cactgcccag acctagcagt gacatctcat     5340

tgtccccagc ccagtgggca ttggaggtgc caggggagtc agggttgtag ccaagacgcc     5400

cccgcacggg gagggttggg aagggggtgc aggaagctca acccctctgg gcaccaaccc     5460

tgcattgcag gttggcacct tacttccctg ggatccccag agttggtcca aggagggaga     5520

gtgggttctc aatacggtac caaagatata atcacctagg tttacaaata tttttaggac     5580

tcacgttaac tcacatttat acagcagaaa tgctattttg tatgctgttg agtttttcta     5640

tctgtgtact tttttttaag ggaaagattt taatattaaa cctggtgctt ctcactcaca     5700


<210>  3
<211>  855
<212>  PRT
<213>  Wild-type DDR2 protein (Homo sapiens)

<400>  3

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  4
<211>  10166
<212>  DNA
<213>  Wild-type DDR2 protein (Homo sapiens)

<400>  4
caaaggcatc ttgcatcagc ctgtggatgt atgcctacca ccgggctcct tcaccagcaa       60

agtggaaaaa gaagcgtttc acaacaaatt cttctttttg ggttggggaa acgcagtgga      120

ttatagctct gttttcttct ttccaaaact gtgcacccct ggatgaaacc tccatcaagg      180

gagacctgca agttgcctgg ggttcagtgc tctagaaagt tccaaggttt gtggcttgaa      240

ttattctaaa gaagctgaaa taattgaaga gaagcagagg ccagctgttt ttgaggatcc      300

tgctccacag agaatgctct gcacccgttg atatgcctcc caggacccag agggagactg      360

tagcctcatt tctgtggaga cctttggctg gactctcctg gctctcccag agactccagt      420

tccaacacca tcttctgaga tgatcctgat tcccagaatg ctcttggtgc tgttcctgct      480

gctgcctatc ttgagttctg caaaagctca ggttaatcca gctatatgcc gctatcctct      540

gggcatgtca ggaggccaga ttccagatga ggacatcaca gcttccagtc agtggtcaga      600

gtccacagct gccaaatatg gaaggctgga ctcagaagaa ggggatggag cctggtgccc      660

tgagattcca gtggaacctg atgacctgaa ggagtttctg cagattgact tgcacaccct      720

ccattttatc actctggtgg ggacccaggg gcgccatgca ggaggtcatg gcatcgagtt      780

tgcccccatg tacaagatca attacagtcg ggatggcact cgctggatct cttggcggaa      840

ccgtcatggg aaacaggtgc tggatggaaa tagtaacccc tatgacattt tcctaaagga      900

cttggagccg cccattgtag ccagatttgt ccggttcatt ccagtcaccg accactccat      960

gaatgtgtgt atgagagtgg agctttacgg ctgtgtctgg ctagatggct tggtgtctta     1020

caatgctcca gctgggcagc agtttgtact ccctggaggt tccatcattt atctgaatga     1080

ttctgtctat gatggagctg ttggatacag catgacagaa gggctaggcc aattgaccga     1140

tggtgtgtct ggcctggacg atttcaccca gacccatgaa taccacgtgt ggcccggcta     1200

tgactatgtg ggctggcgga acgagagtgc caccaatggc tacattgaga tcatgtttga     1260

atttgaccgc atcaggaatt tcactaccat gaaggtccac tgcaacaaca tgtttgctaa     1320

aggtgtgaag atctttaagg aggtacagtg ctacttccgc tctgaagcca gtgagtggga     1380

acctaatgcc atttccttcc cccttgtcct ggatgacgtc aaccccagtg ctcggtttgt     1440

cacggtgcct ctccaccacc gaatggccag tgccatcaag tgtcaatacc attttgcaga     1500

tacctggatg atgttcagtg agatcacctt ccaatcagat gctgcaatgt acaacaactc     1560

tgaagccctg cccacctctc ctatggcacc cacaacctat gatccaatgc ttaaagttga     1620

tgacagcaac actcggatcc tgattggctg cttggtggcc atcatcttta tcctcctggc     1680

catcattgtc atcatcctct ggaggcagtt ctggcagaaa atgctggaga aggcttctcg     1740

gaggatgctg gatgatgaaa tgacagtcag cctttccctg ccaagtgatt ctagcatgtt     1800

caacaataac cgctcctcat cacctagtga acaagggtcc aactcgactt acgatcgcat     1860

ctttcccctt cgccctgact accaggagcc atccaggctg atacgaaaac tcccagaatt     1920

tgctccaggg gaggaggagt caggctgcag cggtgttgtg aagccagtcc agcccagtgg     1980

ccctgagggg gtgccccact atgcagaggc tgacatagtg aacctccaag gagtgacagg     2040

aggcaacaca tactcagtgc ctgccgtcac catggacctg ctctcaggaa aagatgtggc     2100

tgtggaggag ttccccagga aactcctaac tttcaaagag aagctgggag aaggacagtt     2160

tggggaggtt catctctgtg aagtggaggg aatggaaaaa ttcaaagaca aagattttgc     2220

cctagatgtc agtgccaacc agcctgtcct ggtggctgtg aaaatgctcc gagcagatgc     2280

caacaagaat gccaggaatg attttcttaa ggagataaag atcatgtctc ggctcaagga     2340

cccaaacatc atccatctat tagctgtgtg tatcactgat gaccctctct gtatgatcac     2400

tgaatacatg gagaatggag atctcaatca gtttctttcc cgccacgagc cccctaattc     2460

ttcctccagc gatgtacgca ctgtcagtta caccaatctg aagtttatgg ctacccaaat     2520

tgcctctggc atgaagtacc tttcctctct taattttgtt caccgagatc tggccacacg     2580

aaactgttta gtgggtaaga actacacaat caagatagct gactttggaa tgagcaggaa     2640

cctgtacagt ggtgactatt accggatcca gggccgggca gtgctcccta tccgctggat     2700

gtcttgggag agtatcttgc tgggcaagtt cactacagca agtgatgtgt gggcctttgg     2760

ggttactttg tgggagactt tcaccttttg tcaagaacag ccctattccc agctgtcaga     2820

tgaacaggtt attgagaata ctggagagtt cttccgagac caagggaggc agacttacct     2880

ccctcaacca gccatttgtc ctgactctgt gtataagctg atgctcagct gctggagaag     2940

agatacgaag aaccgtccct cattccaaga aatccacctt ctgctccttc aacaaggcga     3000

cgagtgatgc tgtcagtgcc tggccatgtt cctacggctc aggtcctccc tacaagacct     3060

accactcacc catgcctatg ccactccatc tggacattta atgaaactga gagacagagg     3120

cttgtttgct ttgccctctt ttcctggtca cccccactcc ctacccctga ctcatataca     3180

cttttttttt tttttacatt aaagaactaa aaaaggaaaa aaaaaagcct agggcagata     3240

caatctagta aaagaaaatc tttgatatac caaagtgttg gataacaaag gctagaaaat     3300

tcagataatt tataaaggtt aactatactt gtgcttataa atgtgcagat tctacaatat     3360

ttttccatgt cattctaaaa gaatcttcag aaagaaaaac ttgaagaata ctaatgtctt     3420

gggaaacatg agattaagtt tagggaaaac acttgataga tgtggagaat ctgaggactc     3480

agaattcagc aactaatcac aggtggtttt ctaatttggc ctctggacat gtctcactgt     3540

ttgtatttct ctctcctgtc aaagtgaatg atatattctt gaaaaccccc aatttcttga     3600

aatgggtgtt ctgttcattc atgggcaggg gtcaggattg aagttcatat atgaaacaac     3660

tggggatgta gataggaaag aatgtctgct gcaagagtgt atgaaggggg attgtcattt     3720

acaaaaaaaa agtacctcat ggatggaagg attcatgaat agataatgga cataggaaag     3780

gaggtcaatg gaggacacat aacagacatg ctatccacca tttatttgtg attttgtaag     3840

agggttctct tctttgtctt gttcagatat tttcatgtgt gtgttttagt gagaatctga     3900

gtttttaatc agtaaagtct gatgttttga tatcttgatg ttttgatggt agactcttga     3960

gttcatcttg tccaaatctt ctagcatttt caaggatgaa gcctctgtgg gatctttggg     4020

cttggggctg aatttctcag gcataaatac ctaatggcct tgtctaagag ggaatagatc     4080

tgttctgagt gtccccaaaa aagttgtcct aggaactgat gtggagaagt tacagggaga     4140

ctgatttcca ttccttattg gggaaaacga agcactcaga acatacaagg ataaatgggc     4200

tgccaccaga ggtgaggagt ctcttgtcac tggagaggtt aagatagagg ctcaagaaca     4260

atgcaaggaa aatggaggtt ttcaaacaca aagtggatgg tggtatgaga caatgtttaa     4320

tgtccttcta actccgagag tccttgattc tggagaggca caggatgaac atctgttgct     4380

actgctgagt atacacactc ttgcctctga gatggcgtga ccagcagaaa agaaagctca     4440

gggctgtggc ttcagaattc atggaaacag agccactgtc aagaaggaat ctgctcagag     4500

cagattctga gttttcacac tccacaaatc ctcagattta gtgggaagct ggaaaaagga     4560

actcttaatt ccaattgagg agaaacaaga aaacattaca aatcagtttc ccaagctgag     4620

aaggattagc cttgacccct tgggtctgcc tctgttgccc tcaccagttt accttctaca     4680

acagtttctc aggaacatgt gtatttcccc attcagcttt cagcattgct ccacgccaca     4740

gcataagcat agatcccaag tccacaggct ccattttgca ggtcatcttc tgatcctagc     4800

aaatgtcctt tccccatagt tgtcctatgc ctttgggctt tagtctatcc caggactaac     4860

tgtggagaaa tcattggttt gagagtcaag agagcattgg tttgggagct ttaatcctct     4920

ttctgcttca cactaagtgt gtcatcttgg ctaaatcact tggtctttct gcattttgtt     4980

ttcttattta taggatgagg aaattagatt aaatggtttt gaggtccttt cttgttctga     5040

tatgtccagt actcactgga aaattggatc tataactgat gggtttagta atctggtcat     5100

ttcttgctct gaaaattgta gtcagcaaaa gagatcatgg aagaaatcac tgtaatggta     5160

gtaatagtaa cacatgccat ttgtattgtg ccttaggttt accaggtgtt tccaaataca     5220

ttagcatatt tgatatgtgc aggactagat accttgggac ctgccacact ccactttcaa     5280

gatatgtatt agcttcatta gaattaaagg gacttgaact caggacctgc agcctattct     5340

tctttatcca catgtctctg gtagggctac atccagatca caccatgact tcttatagag     5400

caagagaaaa taatattatt atatcttcct ttgcctaaaa tctctccact tattcttttt     5460

tatgattctg caccagttca ctgggttatt ctatgattcc atattttttt taaaaaaaat     5520

catatttaaa atgaacttac aatgtctgaa ttttcctggc cttgagtcac agaagtaata     5580

tgtttcagat ggctgcccaa tatgtattat catgtaatac atatctgtgt ccttttctgg     5640

gatgaggaag gcttcaactt ctggcactga gaactttgta ttacagacac aggtttagtt     5700

tctagcttag tcatgccttt agagtttagt agcacaaatc catgcaaccc aacagaatac     5760

atggtgaggg cctagtatgt agaatttgaa agtagttcaa atttgaatta gaagaatgaa     5820

gctaggactt atttggaaaa ggagatagaa aaaaaatgat cagaaactgt ggggccttat     5880

tacctttgca gtaagttatc ttcttcatga tatatgtgaa ttattttatg tgcagattgt     5940

gttttgggat tgtcagatct aaacttatat tcttgctggc taatgtgctg atagccaggt     6000

ctgaaacttg atgtgctatc cagacacata tgatcagaaa agatctagag tgcaaagagg     6060

tgcctgagga gcaaaatgtg gttttaatgt tgtggaaaga tcacttgcaa gtatataaga     6120

ctgtataaag aagaggactg tgtgcaagtg gggtgaaaaa aaaggatacg tgaatgtgca     6180

tatgactgaa tagggaggaa ggtcagggct agaaaggagg ctacataaaa aggggcaatg     6240

gagaatgcac aggaaagaca caggggaagg tcaagtcgag caaggtagaa acaggagtag     6300

ctagagccat tgggaatcca ttttgaaaca agaaggagtt ttgaaaggga ataggaaagt     6360

aagtgtcttg aagtaaaaga taaatatgga tggagaaaga agaaattctg gatgatagag     6420

atgataaaaa tatttattaa gaaatgaagt caggttcagt gtatgaaatg gaaaggaatt     6480

tttcagaatt ttaagaaagg ggaagttcct cttggaaaag atatagcaac catcggggaa     6540

tgaccttttc atttcagaag tggatgagga aggtggtgtg agcatcaggt atattctgga     6600

ccatttcaag tgctggtgag aagaaaggaa ctctttgcct gaactgggct tggttttcca     6660

agtgctgctt tggaaatgaa gacccagaga tgcagagctt atggtagttc ataaatcttc     6720

atgttctatt atctttcatc tgccaataaa gttcattttc aataatgtcc accattgctg     6780

tgcccagaat aaccacaggc aaacatcaaa acaatacgca taagttagac aagattaaat     6840

cttgtctgat atctgcacaa acagatatgc accatgttgg aaacatgtgt tttcctagtc     6900

ccatccaggc ttcccacaag aaagccatga tgtgggtcta aaccatatgt tttgagtaaa     6960

ggagaataga agaaggggag tgtccgcaaa atggaaagag atgaagatgt tccaaggaag     7020

tatgctgaaa cagaacagtg aatgttttgc ccaaaactac aaaaataaaa gaaaaaaaga     7080

aaattgcaat acatggctac taagtctttg atcataagtc gaatttatag acctggaatt     7140

tgccatccta gtctttcctt tttagtaaga cttctgtcct ctggcagtgc atatggtagg     7200

tctctaatgt ttcttcatct ccaggaagat gcagatcctt atttttgctg ggaaatcctt     7260

ctaaatagaa atgtaacatt tttataaaaa cagattaatg tgtttttcac ttagtaaatg     7320

ttttcaagag ctgaattgag aaggaaagag actggagtgg ttaatggtga tttgatttct     7380

ggcattctga gttttctgct acaattagct gcattacttg gtgccaaaga gcagtgggga     7440

attgttgagt tgctgtatcc tttaaaaaaa aacaaaaaac ttgttatttt gaaagaactt     7500

aaggctcaca agatgttaca aaaatagtag agtggcctta ccctagatcc agttttcccc     7560

atttataaca tttcacttag tccattttcg gaaccagaaa attaacattg gcataatgct     7620

attaactaaa ctacagacct tttttcaatt tcgccagttt ttccacacat attcatttag     7680

ttgctggata cttttaattc ttgctgattt gtaaactggc cttgcttgga tacaacagga     7740

aagatactat ctggataaag ttctacagtt ttagagagac tattaacaca ttaatgtgtt     7800

cctttgtcat gagcaatacc ctgcctacac tgcttctaaa ttttctgatt tgtttggctg     7860

tttggcatct gaaacaatcc aagacaaact tagaaagatt aggcaacaca aaacacagta     7920

agacctgttc atagcttgtt gtctagaaaa ccaggtagca ggatattcta gatgcttcct     7980

gctgcttcta cgtgagtagg attagcactg gggacaaaat aaggagttta gagtaaacca     8040

gtatttcagt caagagttag ttggcactta gttaatggca ctggaaatag cttgtggaga     8100

gaatagaata caatggtata gactcctaat gtttgataaa atactatttt cagagtggta     8160

gagaggtttt atttgcctaa atagccgtta ttaaatggaa taacaaccac attagaccaa     8220

attaattgca aacacagcgg caacctgggg agaagttgaa actccagttt tgtggattac     8280

agttttgagt tttatgattg acatttttaa gtcccctatt taaggggtca agattataac     8340

aatgtgtgtc ttactaagtt tctaggtcat tgtgagcact tgataaatat ttgctgaatg     8400

ttgttttttt gaatgaacat aagatagaaa caaaaacttc tcatccagtt aactagagtg     8460

aatgtaggga gaattgtttt gcttgtaaca tggagagttt attttcaagt gaggaaagag     8520

aaaaaaatta ctcagacttg ttcctggtga agtgcattct ctgtttgtat actttttgat     8580

ggagaaattg atctatagaa ctgcttaatt ttttgaggca tttagacagc aatgaaaggt     8640

agttctccac aggacaccga atcaaaagga gagaccagac tctggcctca tacccagcct     8700

atttgaaaca agctatctag tttctcctgc agacaccttg tcaacaacat gcaacagtgt     8760

caggtgcctt gcaggaaaat aatctgagtc ccaagctagc ctgtgctcat ccacaatcac     8820

aatgaacatg tcaaggaaga atttgcagag actcaaggga agcacaatgg gataaggtaa     8880

tcactttcag tgaaaaactg ttttcttgaa aacaggcttg gacacaattg aaagctggct     8940

tcctgcaaac acaccaagag tctgtaatct agcctatcca ttatatgtcc tttattattc     9000

atgatatcct attcttctac cttgttgcct ggtaactttt tctgaggact gagtttctgc     9060

agcgatgtgg tgcactcttc ctgtgatgag gaaacatctg ggcccccttc tgcaggcttt     9120

ggaagatgat gtgtcttgtc aaggggtaaa gggcaaatgg atttaatttc tgcttaaaac     9180

tatcatagac gttccaaata gaatatgtaa aatttctctg tattagaaaa agaaacgtga     9240

taccaattgt atattttctt ttctttattt attctctgta agtctgtcag atgataaatt     9300

gtaaataaca atgattaaag agtcatgcta ctgatggatc tccctttctg tataaacagt     9360

gccagttctg ggctttgtaa cctttgctct ttatagtctt tcattcctgg ggaagtgatg     9420

gggcatgggc ccagagctgg ggtgtatgtg gtatggacac ctgtttgtgg ggctttccag     9480

caaaggatta tttaaataga cctctaacat atgagttgac tgtttattgg gaagaaagca     9540

tcttggtctc tgacatatcc aaacatacga gacactggga ttttacgtcc tcacattaat     9600

tagtccagtt ctggggaatc cagtctagaa ttaactggtg atcccttatc gttatggtta     9660

cagacttgtc ttgtttgata cacagaaatc ctttttaaat ccaaatatag tctgtctcag     9720

actacctgca catgcacaaa ccaaaaaaaa ctatgaaaac cagaatttag actcagtcat     9780

tatactagag attagaatga aacgacccca aacaacccat ttcttacctg gtctctgaga     9840

ataagtttat acttttagtt ttctgagaat atttctcaga atatgtgagt tttctgagca     9900

catttttcag catggggtat ggtagataaa tcacagggcc aaggtttggc agggatagat     9960

gggatcattg tgtaccctat tgttcttctg atttccagga gaacagaatg agcccatgca    10020

aaacataaac ttatgatgat taaaaaaaac acacctatcc attcactcat caataaaaac    10080

atattatgat ggttatcaag ctgtgtccta tgagtgataa aatatttgta aaatataaaa    10140

ttaaatggca tctattttga actcta                                         10166


