                         SEQUENCE LISTING

<110>  Vrije Universiteit Brussel
 
<120>  MUSCLE-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND 
       USE THEREOF

<130>  VUB-085-PCT

<150>  20158057.8
<151>  2020-02-18

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  454
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSk-SH5

<400>  1
cagtttactc accagggatt cagaggcagc actgctgaac cctgagccct tggcacatca       60

ggttggctgt cagaagtcgg cctttgtaca tacacagttc ccttgtgagg cccagctgcg      120

tgtcctagga gcggggcctc tctccacagc agagctcagc ctctcaagtg tatggacagc      180

acgggtgcct gatgggtgga tttagccatg agttgaaggt ggcttgggga gaatgagagt      240

tctagagata gggagaaggg gttgccaata ggagagtgga attcctgagc acctcgtcac      300

aggcagccga cagaacatga gccgcagggc ccaggctatt tatacctcgc ctgtcactat      360

cagggtcccc acagctcccc ccacctccag ccacacacag caggtccttt tgctctttct      420

ggtcccttct ctactcctcc ccctccctac ctaa                                  454


<210>  2
<211>  452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02

<400>  2
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta gg                                    452


<210>  3
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE04

<400>  3
ccttttagag aatccacacc tgtcccagtt gctgggttcc actaccaaaa gtgaattgca       60

actattttag gagcacttaa gcacatccga aaaatgagtg attctgttct ggcccacacc      120

acatcactga tgtaccccct taaagcatgt ccctgagttc atcacagaag actgctcctc      180

ctgtgccctc cacaaggtta gaactgtcct tgtcttaggg aaaaaggaga gagagagaga      240

gagagagaga gagagagaga gagagagaga gagagaggga caggcaccaa ctgggtaacc      300

tctgctgacc cccactctac tttaccataa gtagctccaa atccttctag aaaatctgaa      360

aggcatagcc ccatatatca gtgatataaa tagaacctgc agcaggctct ggtaaatgat      420

gactacaagg tggactggga ggcagcccgg ccttggcagg catcatcctc taaatataaa      480

gatgagtttg ttcagccttt gcagaagga                                        509


<210>  4
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE06

<400>  4
gggccagggg acggtggctt ctacgtgctt gggacgttcc cagccaccgt cccatgttcc       60

cggcgggggg ccagctgtcc ccaccgccag cccaactcag cacttggtca gggtatcagc      120

ttggtggggg ggcgtgagcc cagcccctgg ggcggctcag cccatacaag gccatggggc      180

tgggcgcaaa gcatgcctgg gttcagggtg ggtatggtgc gggagcaggg aggtgagagg      240

ctcagctgcc ctccagaact cctccctggg gacaacccct cccagccaat agcacagcct      300

aggtccccct atataaggcc acggctgctg gcccttcctt tgggtcagtg tcacctccag      360

gatacagaca gccccccttc agcccagccc agccaggtac                            400


<210>  5
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE04

<400>  5
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc gtcgacggat ccccttttag      480

agaatccaca cctgtcccag ttgctgggtt ccactaccaa aagtgaattg caactatttt      540

aggagcactt aagcacatcc gaaaaatgag tgattctgtt ctggcccaca ccacatcact      600

gatgtacccc cttaaagcat gtccctgagt tcatcacaga agactgctcc tcctgtgccc      660

tccacaaggt tagaactgtc cttgtcttag ggaaaaagga gagagagaga gagagagaga      720

gagagagaga gagagagaga gagagagagg gacaggcacc aactgggtaa cctctgctga      780

cccccactct actttaccat aagtagctcc aaatccttct agaaaatctg aaaggcatag      840

ccccatatat cagtgatata aatagaacct gcagcaggct ctggtaaatg atgactacaa      900

ggtggactgg gaggcagccc ggccttggca ggcatcatcc tctaaatata aagatgagtt      960

tgttcagcct ttgcagaagg a                                                981


<210>  6
<211>  872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE06

<400>  6
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc gtcgacggat ccgggccagg      480

ggacggtggc ttctacgtgc ttgggacgtt cccagccacc gtcccatgtt cccggcgggg      540

ggccagctgt ccccaccgcc agcccaactc agcacttggt cagggtatca gcttggtggg      600

ggggcgtgag cccagcccct ggggcggctc agcccataca aggccatggg gctgggcgca      660

aagcatgcct gggttcaggg tgggtatggt gcgggagcag ggaggtgaga ggctcagctg      720

ccctccagaa ctcctccctg gggacaaccc ctcccagcca atagcacagc ctaggtcccc      780

ctatataagg ccacggctgc tggcccttcc tttgggtcag tgtcacctcc aggatacaga      840

cagcccccct tcagcccagc ccagccaggt ac                                    872


<210>  7
<211>  929
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE04-CRE06

<400>  7
ccttttagag aatccacacc tgtcccagtt gctgggttcc actaccaaaa gtgaattgca       60

actattttag gagcacttaa gcacatccga aaaatgagtg attctgttct ggcccacacc      120

acatcactga tgtaccccct taaagcatgt ccctgagttc atcacagaag actgctcctc      180

ctgtgccctc cacaaggtta gaactgtcct tgtcttaggg aaaaaggaga gagagagaga      240

gagagagaga gagagagaga gagagagaga gagagaggga caggcaccaa ctgggtaacc      300

tctgctgacc cccactctac tttaccataa gtagctccaa atccttctag aaaatctgaa      360

aggcatagcc ccatatatca gtgatataaa tagaacctgc agcaggctct ggtaaatgat      420

gactacaagg tggactggga ggcagcccgg ccttggcagg catcatcctc taaatataaa      480

gatgagtttg ttcagccttt gcagaaggag gcgcgccgtc gacggatccg ggccagggga      540

cggtggcttc tacgtgcttg ggacgttccc agccaccgtc ccatgttccc ggcggggggc      600

cagctgtccc caccgccagc ccaactcagc acttggtcag ggtatcagct tggtgggggg      660

gcgtgagccc agcccctggg gcggctcagc ccatacaagg ccatggggct gggcgcaaag      720

catgcctggg ttcagggtgg gtatggtgcg ggagcaggga ggtgagaggc tcagctgccc      780

tccagaactc ctccctgggg acaacccctc ccagccaata gcacagccta ggtcccccta      840

tataaggcca cggctgctgg cccttccttt gggtcagtgt cacctccagg atacagacag      900

ccccccttca gcccagccca gccaggtac                                        929


<210>  8
<211>  929
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE06-CRE04

<400>  8
gggccagggg acggtggctt ctacgtgctt gggacgttcc cagccaccgt cccatgttcc       60

cggcgggggg ccagctgtcc ccaccgccag cccaactcag cacttggtca gggtatcagc      120

ttggtggggg ggcgtgagcc cagcccctgg ggcggctcag cccatacaag gccatggggc      180

tgggcgcaaa gcatgcctgg gttcagggtg ggtatggtgc gggagcaggg aggtgagagg      240

ctcagctgcc ctccagaact cctccctggg gacaacccct cccagccaat agcacagcct      300

aggtccccct atataaggcc acggctgctg gcccttcctt tgggtcagtg tcacctccag      360

gatacagaca gccccccttc agcccagccc agccaggtac ggcgcgccgt cgacggatcc      420

ccttttagag aatccacacc tgtcccagtt gctgggttcc actaccaaaa gtgaattgca      480

actattttag gagcacttaa gcacatccga aaaatgagtg attctgttct ggcccacacc      540

acatcactga tgtaccccct taaagcatgt ccctgagttc atcacagaag actgctcctc      600

ctgtgccctc cacaaggtta gaactgtcct tgtcttaggg aaaaaggaga gagagagaga      660

gagagagaga gagagagaga gagagagaga gagagaggga caggcaccaa ctgggtaacc      720

tctgctgacc cccactctac tttaccataa gtagctccaa atccttctag aaaatctgaa      780

aggcatagcc ccatatatca gtgatataaa tagaacctgc agcaggctct ggtaaatgat      840

gactacaagg tggactggga ggcagcccgg ccttggcagg catcatcctc taaatataaa      900

gatgagtttg ttcagccttt gcagaagga                                        929


<210>  9
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE04-CRE06

<400>  9
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc cgtacggtcg acggatcccc      480

ttttagagaa tccacacctg tcccagttgc tgggttccac taccaaaagt gaattgcaac      540

tattttagga gcacttaagc acatccgaaa aatgagtgat tctgttctgg cccacaccac      600

atcactgatg taccccctta aagcatgtcc ctgagttcat cacagaagac tgctcctcct      660

gtgccctcca caaggttaga actgtccttg tcttagggaa aaaggagaga gagagagaga      720

gagagagaga gagagagaga gagagagaga gagagggaca ggcaccaact gggtaacctc      780

tgctgacccc cactctactt taccataagt agctccaaat ccttctagaa aatctgaaag      840

gcatagcccc atatatcagt gatataaata gaacctgcag caggctctgg taaatgatga      900

ctacaaggtg gactgggagg cagcccggcc ttggcaggca tcatcctcta aatataaaga      960

tgagtttgtt cagcctttgc agaaggaggc gcgccgtcga cggatccggg ccaggggacg     1020

gtggcttcta cgtgcttggg acgttcccag ccaccgtccc atgttcccgg cggggggcca     1080

gctgtcccca ccgccagccc aactcagcac ttggtcaggg tatcagcttg gtgggggggc     1140

gtgagcccag cccctggggc ggctcagccc atacaaggcc atggggctgg gcgcaaagca     1200

tgcctgggtt cagggtgggt atggtgcggg agcagggagg tgagaggctc agctgccctc     1260

cagaactcct ccctggggac aacccctccc agccaatagc acagcctagg tccccctata     1320

taaggccacg gctgctggcc cttcctttgg gtcagtgtca cctccaggat acagacagcc     1380

ccccttcagc ccagcccagc caggtac                                         1407


<210>  10
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE04-CSk-SH5

<400>  10
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc gtcgacggat ccccttttag      480

agaatccaca cctgtcccag ttgctgggtt ccactaccaa aagtgaattg caactatttt      540

aggagcactt aagcacatcc gaaaaatgag tgattctgtt ctggcccaca ccacatcact      600

gatgtacccc cttaaagcat gtccctgagt tcatcacaga agactgctcc tcctgtgccc      660

tccacaaggt tagaactgtc cttgtcttag ggaaaaagga gagagagaga gagagagaga      720

gagagagaga gagagagaga gagagagagg gacaggcacc aactgggtaa cctctgctga      780

cccccactct actttaccat aagtagctcc aaatccttct agaaaatctg aaaggcatag      840

ccccatatat cagtgatata aatagaacct gcagcaggct ctggtaaatg atgactacaa      900

ggtggactgg gaggcagccc ggccttggca ggcatcatcc tctaaatata aagatgagtt      960

tgttcagcct ttgcagaagg aggatccgtc gacggcgcgc cacgcgtcag tttactcacc     1020

agggattcag aggcagcact gctgaaccct gagcccttgg cacatcaggt tggctgtcag     1080

aagtcggcct ttgtacatac acagttccct tgtgaggccc agctgcgtgt cctaggagcg     1140

gggcctctct ccacagcaga gctcagcctc tcaagtgtat ggacagcacg ggtgcctgat     1200

gggtggattt agccatgagt tgaaggtggc ttggggagaa tgagagttct agagataggg     1260

agaaggggtt gccaatagga gagtggaatt cctgagcacc tcgtcacagg cagccgacag     1320

aacatgagcc gcagggccca ggctatttat acctcgcctg tcactatcag ggtccccaca     1380

gctcccccca cctccagcca cacacagcag gtccttttgc tctttctggt cccttctcta     1440

ctcctccccc tccctaccta a                                               1461


<210>  11
<211>  1352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE06-Csk-SH5

<400>  11
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc gtcgacggat ccgggccagg      480

ggacggtggc ttctacgtgc ttgggacgtt cccagccacc gtcccatgtt cccggcgggg      540

ggccagctgt ccccaccgcc agcccaactc agcacttggt cagggtatca gcttggtggg      600

ggggcgtgag cccagcccct ggggcggctc agcccataca aggccatggg gctgggcgca      660

aagcatgcct gggttcaggg tgggtatggt gcgggagcag ggaggtgaga ggctcagctg      720

ccctccagaa ctcctccctg gggacaaccc ctcccagcca atagcacagc ctaggtcccc      780

ctatataagg ccacggctgc tggcccttcc tttgggtcag tgtcacctcc aggatacaga      840

cagcccccct tcagcccagc ccagccaggt acggatccgt cgacggcgcg ccacgcgtca      900

gtttactcac cagggattca gaggcagcac tgctgaaccc tgagcccttg gcacatcagg      960

ttggctgtca gaagtcggcc tttgtacata cacagttccc ttgtgaggcc cagctgcgtg     1020

tcctaggagc ggggcctctc tccacagcag agctcagcct ctcaagtgta tggacagcac     1080

gggtgcctga tgggtggatt tagccatgag ttgaaggtgg cttggggaga atgagagttc     1140

tagagatagg gagaaggggt tgccaatagg agagtggaat tcctgagcac ctcgtcacag     1200

gcagccgaca gaacatgagc cgcagggccc aggctattta tacctcgcct gtcactatca     1260

gggtccccac agctcccccc acctccagcc acacacagca ggtccttttg ctctttctgg     1320

tcccttctct actcctcccc ctccctacct aa                                   1352


<210>  12
<211>  1409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE04-CRE06-Csk-SH5

<400>  12
ccttttagag aatccacacc tgtcccagtt gctgggttcc actaccaaaa gtgaattgca       60

actattttag gagcacttaa gcacatccga aaaatgagtg attctgttct ggcccacacc      120

acatcactga tgtaccccct taaagcatgt ccctgagttc atcacagaag actgctcctc      180

ctgtgccctc cacaaggtta gaactgtcct tgtcttaggg aaaaaggaga gagagagaga      240

gagagagaga gagagagaga gagagagaga gagagaggga caggcaccaa ctgggtaacc      300

tctgctgacc cccactctac tttaccataa gtagctccaa atccttctag aaaatctgaa      360

aggcatagcc ccatatatca gtgatataaa tagaacctgc agcaggctct ggtaaatgat      420

gactacaagg tggactggga ggcagcccgg ccttggcagg catcatcctc taaatataaa      480

gatgagtttg ttcagccttt gcagaaggag gcgcgccgtc gacggatccg ggccagggga      540

cggtggcttc tacgtgcttg ggacgttccc agccaccgtc ccatgttccc ggcggggggc      600

cagctgtccc caccgccagc ccaactcagc acttggtcag ggtatcagct tggtgggggg      660

gcgtgagccc agcccctggg gcggctcagc ccatacaagg ccatggggct gggcgcaaag      720

catgcctggg ttcagggtgg gtatggtgcg ggagcaggga ggtgagaggc tcagctgccc      780

tccagaactc ctccctgggg acaacccctc ccagccaata gcacagccta ggtcccccta      840

tataaggcca cggctgctgg cccttccttt gggtcagtgt cacctccagg atacagacag      900

ccccccttca gcccagccca gccaggtacg gatccgtcga cggcgcgcca cgcgtcagtt      960

tactcaccag ggattcagag gcagcactgc tgaaccctga gcccttggca catcaggttg     1020

gctgtcagaa gtcggccttt gtacatacac agttcccttg tgaggcccag ctgcgtgtcc     1080

taggagcggg gcctctctcc acagcagagc tcagcctctc aagtgtatgg acagcacggg     1140

tgcctgatgg gtggatttag ccatgagttg aaggtggctt ggggagaatg agagttctag     1200

agatagggag aaggggttgc caataggaga gtggaattcc tgagcacctc gtcacaggca     1260

gccgacagaa catgagccgc agggcccagg ctatttatac ctcgcctgtc actatcaggg     1320

tccccacagc tccccccacc tccagccaca cacagcaggt ccttttgctc tttctggtcc     1380

cttctctact cctccccctc cctacctaa                                       1409


<210>  13
<211>  1409
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE06-CRE04-Csk-SH5

<400>  13
gggccagggg acggtggctt ctacgtgctt gggacgttcc cagccaccgt cccatgttcc       60

cggcgggggg ccagctgtcc ccaccgccag cccaactcag cacttggtca gggtatcagc      120

ttggtggggg ggcgtgagcc cagcccctgg ggcggctcag cccatacaag gccatggggc      180

tgggcgcaaa gcatgcctgg gttcagggtg ggtatggtgc gggagcaggg aggtgagagg      240

ctcagctgcc ctccagaact cctccctggg gacaacccct cccagccaat agcacagcct      300

aggtccccct atataaggcc acggctgctg gcccttcctt tgggtcagtg tcacctccag      360

gatacagaca gccccccttc agcccagccc agccaggtac ggcgcgccgt cgacggatcc      420

ccttttagag aatccacacc tgtcccagtt gctgggttcc actaccaaaa gtgaattgca      480

actattttag gagcacttaa gcacatccga aaaatgagtg attctgttct ggcccacacc      540

acatcactga tgtaccccct taaagcatgt ccctgagttc atcacagaag actgctcctc      600

ctgtgccctc cacaaggtta gaactgtcct tgtcttaggg aaaaaggaga gagagagaga      660

gagagagaga gagagagaga gagagagaga gagagaggga caggcaccaa ctgggtaacc      720

tctgctgacc cccactctac tttaccataa gtagctccaa atccttctag aaaatctgaa      780

aggcatagcc ccatatatca gtgatataaa tagaacctgc agcaggctct ggtaaatgat      840

gactacaagg tggactggga ggcagcccgg ccttggcagg catcatcctc taaatataaa      900

gatgagtttg ttcagccttt gcagaaggag gatccgtcga cggcgcgcca cgcgtcagtt      960

tactcaccag ggattcagag gcagcactgc tgaaccctga gcccttggca catcaggttg     1020

gctgtcagaa gtcggccttt gtacatacac agttcccttg tgaggcccag ctgcgtgtcc     1080

taggagcggg gcctctctcc acagcagagc tcagcctctc aagtgtatgg acagcacggg     1140

tgcctgatgg gtggatttag ccatgagttg aaggtggctt ggggagaatg agagttctag     1200

agatagggag aaggggttgc caataggaga gtggaattcc tgagcacctc gtcacaggca     1260

gccgacagaa catgagccgc agggcccagg ctatttatac ctcgcctgtc actatcaggg     1320

tccccacagc tccccccacc tccagccaca cacagcaggt ccttttgctc tttctggtcc     1380

cttctctact cctccccctc cctacctaa                                       1409


<210>  14
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Dph-CRE02-CRE04-CRE06-Csk-SH5

<400>  14
gacaggtgcg gttcccggag cgcaggcgca cacatgcacc caccggcgaa cgcggtgacc       60

ctcgccccac cccatcccct ccggcgggca actgggtcgg gtcaggaggg gcaaacccgc      120

tagggagaca ctccatatac ggcccggccc gcgttacctg ggaccgggcc aacccgctcc      180

ttctttggtc aacgcagggg acccgggcgg gggcccaggc cgcgaaccgg ccgagggagg      240

gggctctagt gcccaacacc caaatatggc tcgagaaggg cagcgacatt cctgcggggt      300

ggcgcggagg gaatgcccgc gggctatata aaacctgagc agagggacaa gcggccaccg      360

cagcggacag cgccaagtga agcctcgctt cccctccgcg gcgaccaggg cccgagccga      420

gagtagcagt tgtagctacc cgcccaggta ggggcgcgcc cgtacggtcg acggatcccc      480

ttttagagaa tccacacctg tcccagttgc tgggttccac taccaaaagt gaattgcaac      540

tattttagga gcacttaagc acatccgaaa aatgagtgat tctgttctgg cccacaccac      600

atcactgatg taccccctta aagcatgtcc ctgagttcat cacagaagac tgctcctcct      660

gtgccctcca caaggttaga actgtccttg tcttagggaa aaaggagaga gagagagaga      720

gagagagaga gagagagaga gagagagaga gagagggaca ggcaccaact gggtaacctc      780

tgctgacccc cactctactt taccataagt agctccaaat ccttctagaa aatctgaaag      840

gcatagcccc atatatcagt gatataaata gaacctgcag caggctctgg taaatgatga      900

ctacaaggtg gactgggagg cagcccggcc ttggcaggca tcatcctcta aatataaaga      960

tgagtttgtt cagcctttgc agaaggaggc gcgccgtcga cggatccggg ccaggggacg     1020

gtggcttcta cgtgcttggg acgttcccag ccaccgtccc atgttcccgg cggggggcca     1080

gctgtcccca ccgccagccc aactcagcac ttggtcaggg tatcagcttg gtgggggggc     1140

gtgagcccag cccctggggc ggctcagccc atacaaggcc atggggctgg gcgcaaagca     1200

tgcctgggtt cagggtgggt atggtgcggg agcagggagg tgagaggctc agctgccctc     1260

cagaactcct ccctggggac aacccctccc agccaatagc acagcctagg tccccctata     1320

taaggccacg gctgctggcc cttcctttgg gtcagtgtca cctccaggat acagacagcc     1380

ccccttcagc ccagcccagc caggtacgga tccgtcgacc gtacgggcgc gccacgcgtc     1440

agtttactca ccagggattc agaggcagca ctgctgaacc ctgagccctt ggcacatcag     1500

gttggctgtc agaagtcggc ctttgtacat acacagttcc cttgtgaggc ccagctgcgt     1560

gtcctaggag cggggcctct ctccacagca gagctcagcc tctcaagtgt atggacagca     1620

cgggtgcctg atgggtggat ttagccatga gttgaaggtg gcttggggag aatgagagtt     1680

ctagagatag ggagaagggg ttgccaatag gagagtggaa ttcctgagca cctcgtcaca     1740

ggcagccgac agaacatgag ccgcagggcc caggctattt atacctcgcc tgtcactatc     1800

agggtcccca cagctccccc cacctccagc cacacacagc aggtcctttt gctctttctg     1860

gtcccttctc tactcctccc cctccctacc taa                                  1893


<210>  15
<211>  334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spc5-12 promoter

<400>  15
tggccaccgc cttcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg       60

tggggagtta tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa      120

aaataactcc cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac      180

ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg      240

gccgggcggt gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag      300

ctacccggag gagcgggagg cgccaagctc taga                                  334


<210>  16
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MVM intron

<400>  16
aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag       60

cacctgcctg aaatcacttt ttttcaggtt gg                                     92


<210>  17
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pA signal

<400>  17
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  18
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  18
atggcggcag cggcggcggc ggctgcagaa cagcaaagtt ccaatggtcc tgtaaagaag       60

tccatgcgtg agaaggctgt tgagagaagg agtgtcaata aagagcacaa cagtaacttt      120

aaagctggat acattccgat tgatgaagat cgtctccaca aaacagggtt gagaggaaga      180

aagggcaatt tagccatctg tgtgattatc ctcttgttta tcctggctgt catcaattta      240

ataataacac ttgttatttg ggccgtgatt cgcattggac caaatggctg tgatagtatg      300

gagtttcatg aaagtggcct gcttcgattt aagcaagtat ctgacatggg agtgatccac      360

cctctttata aaagcacagt aggaggaagg cgaaatgaaa atttggtcat cactggcaac      420

aaccagccta ttgtttttca gcaagggaca acaaagctca gtgtagaaaa caacaaaact      480

tctattacaa gtgacatcgg catgcagttt tttgacccga ggactcaaaa tatcttattc      540

agcacagact atgaaactca tgagtttcat ttgccaagtg gagtgaaaag tttgaatgtt      600

caaaaggcat ctactgaaag gattaccagc aatgctacca gtgatttaaa tataaaagtt      660

gatgggcgtg ctattgtgcg tggaaatgaa ggtgtattca ttatgggcaa aaccattgaa      720

tttcacatgg gtggtaatat ggagttaaag gcggaaaaca gtatcatcct aaatggatct      780

gtgatggtca gcaccacccg cctacccagt tcctccagtg gagaccagtt gggtagtggt      840

gactgggtac gctacaagct ctgcatgtgt gctgatggga cgctcttcaa ggtgcaagta      900

accagccaga acatgggctg ccaaatctca gacaacccct gtggaaacac tcattaa         957


<210>  19
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized beta-sarcoglycan gene

<400>  19
atggctgctg ccgctgctgc tgcagctgaa cagcaatcta gcaacggccc cgtgaagaaa       60

tccatgcgcg agaaggccgt cgagcggaga tctgtgaaca aagagcacaa cagcaacttc      120

aaggccggct acatccccat cgacgaggac agactgcaca agacaggcct gagaggcaga      180

aagggcaatc tggccatctg cgtgatcatc ctgctgttca tcctggccgt gatcaacctg      240

atcatcaccc tggtcatctg ggccgtgatt agaatcggcc ccaacggctg cgacagcatg      300

gaatttcacg agagcggcct gctgcggttc aaacaggtgt ccgatatggg cgtgatccat      360

ccactgtaca agagcaccgt tggcggcaga agaaacgaga atctggtcat caccggcaac      420

aaccagccta tcgtgtttca gcagggcacc accaagctga gcgtggaaaa caacaagacc      480

agcatcacca gcgacatcgg catgcagttc ttcgacccca gaacacagaa catcctgttc      540

agcaccgact acgagacaca cgagttccat ctgcctagcg gcgtgaagtc cctgaatgtg      600

cagaaggcca gcaccgagag aatcaccagc aatgccacct ccgacctgaa catcaaagtg      660

gacggcagag ccatcgtgcg gggaaatgag ggcgtgttca tcatgggcaa gaccatcgag      720

ttccacatgg gcggcaacat ggaactgaag gccgagaaca gcatcatcct gaacggcagc      780

gtgatggtgt ccaccacaag actgccaagc agcagctctg gcgatcagct tggatctggc      840

gactgggtcc gatacaagct gtgtatgtgt gccgacggca ccctgttcaa ggtgcaagtg      900

acaagccaga acatgggctg ccagatcagc gacaaccctt gcggcaatac ccactga         957


<210>  20
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  luciferase gene

<400>  20
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg       60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc      120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc      180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg      240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg      300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc      360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa      420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc      480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac      540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc      600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt      660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg      720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt      780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat      840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc      900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc      960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac     1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc     1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag     1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc     1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc     1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc     1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa     1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg     1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac     1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac     1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt     1620

aaggccaaga agggcggcaa gatcgccgtg taa                                  1653


<210>  21
<211>  4882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  21
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtcag tttactcacc      180

agggattcag aggcagcact gctgaaccct gagcccttgg cacatcaggt tggctgtcag      240

aagtcggcct ttgtacatac acagttccct tgtgaggccc agctgcgtgt cctaggagcg      300

gggcctctct ccacagcaga gctcagcctc tcaagtgtat ggacagcacg ggtgcctgat      360

gggtggattt agccatgagt tgaaggtggc ttggggagaa tgagagttct agagataggg      420

agaaggggtt gccaatagga gagtggaatt cctgagcacc tcgtcacagg cagccgacag      480

aacatgagcc gcagggccca ggctatttat acctcgcctg tcactatcag ggtccccaca      540

gctcccccca cctccagcca cacacagcag gtccttttgc tctttctggt cccttctcta      600

ctcctccccc tccctaccta aggtacccaa cgcgttacgt ggccaccgcc ttcggcacca      660

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      720

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      780

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      840

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      900

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      960

gccaagctct agatctagaa agaggtaagg gtttaaggga tggttggttg gtggggtatt     1020

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaagcttgcc     1080

accatggctg ctgccgctgc tgctgcagct gaacagcaat ctagcaacgg ccccgtgaag     1140

aaatccatgc gcgagaaggc cgtcgagcgg agatctgtga acaaagagca caacagcaac     1200

ttcaaggccg gctacatccc catcgacgag gacagactgc acaagacagg cctgagaggc     1260

agaaagggca atctggccat ctgcgtgatc atcctgctgt tcatcctggc cgtgatcaac     1320

ctgatcatca ccctggtcat ctgggccgtg attagaatcg gccccaacgg ctgcgacagc     1380

atggaatttc acgagagcgg cctgctgcgg ttcaaacagg tgtccgatat gggcgtgatc     1440

catccactgt acaagagcac cgttggcggc agaagaaacg agaatctggt catcaccggc     1500

aacaaccagc ctatcgtgtt tcagcagggc accaccaagc tgagcgtgga aaacaacaag     1560

accagcatca ccagcgacat cggcatgcag ttcttcgacc ccagaacaca gaacatcctg     1620

ttcagcaccg actacgagac acacgagttc catctgccta gcggcgtgaa gtccctgaat     1680

gtgcagaagg ccagcaccga gagaatcacc agcaatgcca cctccgacct gaacatcaaa     1740

gtggacggca gagccatcgt gcggggaaat gagggcgtgt tcatcatggg caagaccatc     1800

gagttccaca tgggcggcaa catggaactg aaggccgaga acagcatcat cctgaacggc     1860

agcgtgatgg tgtccaccac aagactgcca agcagcagct ctggcgatca gcttggatct     1920

ggcgactggg tccgatacaa gctgtgtatg tgtgccgacg gcaccctgtt caaggtgcaa     1980

gtgacaagcc agaacatggg ctgccagatc agcgacaacc cttgcggcaa tacccactga     2040

ttcgaaacgt tcggtccatc ttgagcatct gacttctggc taaataaaag atctttattt     2100

tcattagatc tgtgtgttgg ttttttgtgt gcgtcgagat ccacggccgc aggaacccct     2160

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     2220

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     2280

ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     2340

ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt     2400

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     2460

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     2520

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     2580

ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     2640

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     2700

atctcgggct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     2760

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt     2820

ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac     2880

ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga     2940

caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa     3000

cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     3060

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     3120

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     3180

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     3240

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     3300

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     3360

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     3420

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     3480

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     3540

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     3600

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     3660

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     3720

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     3780

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     3840

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     3900

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     3960

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     4020

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     4080

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     4140

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     4200

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     4260

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     4320

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     4380

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     4440

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     4500

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     4560

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     4620

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     4680

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     4740

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     4800

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     4860

gccttttgct ggccttttgc tc                                              4882


<210>  22
<211>  4882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  22
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtcag tttactcacc      180

agggattcag aggcagcact gctgaaccct gagcccttgg cacatcaggt tggctgtcag      240

aagtcggcct ttgtacatac acagttccct tgtgaggccc agctgcgtgt cctaggagcg      300

gggcctctct ccacagcaga gctcagcctc tcaagtgtat ggacagcacg ggtgcctgat      360

gggtggattt agccatgagt tgaaggtggc ttggggagaa tgagagttct agagataggg      420

agaaggggtt gccaatagga gagtggaatt cctgagcacc tcgtcacagg cagccgacag      480

aacatgagcc gcagggccca ggctatttat acctcgcctg tcactatcag ggtccccaca      540

gctcccccca cctccagcca cacacagcag gtccttttgc tctttctggt cccttctcta      600

ctcctccccc tccctaccta aggtacccaa cgcgttacgt ggccaccgcc ttcggcacca      660

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      720

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      780

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      840

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      900

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      960

gccaagctct agatctagaa agaggtaagg gtttaaggga tggttggttg gtggggtatt     1020

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaagcttgcc     1080

accatggcgg cagcggcggc ggcggctgca gaacagcaaa gttccaatgg tcctgtaaag     1140

aagtccatgc gtgagaaggc tgttgagaga aggagtgtca ataaagagca caacagtaac     1200

tttaaagctg gatacattcc gattgatgaa gatcgtctcc acaaaacagg gttgagagga     1260

agaaagggca atttagccat ctgtgtgatt atcctcttgt ttatcctggc tgtcatcaat     1320

ttaataataa cacttgttat ttgggccgtg attcgcattg gaccaaatgg ctgtgatagt     1380

atggagtttc atgaaagtgg cctgcttcga tttaagcaag tatctgacat gggagtgatc     1440

caccctcttt ataaaagcac agtaggagga aggcgaaatg aaaatttggt catcactggc     1500

aacaaccagc ctattgtttt tcagcaaggg acaacaaagc tcagtgtaga aaacaacaaa     1560

acttctatta caagtgacat cggcatgcag ttttttgacc cgaggactca aaatatctta     1620

ttcagcacag actatgaaac tcatgagttt catttgccaa gtggagtgaa aagtttgaat     1680

gttcaaaagg catctactga aaggattacc agcaatgcta ccagtgattt aaatataaaa     1740

gttgatgggc gtgctattgt gcgtggaaat gaaggtgtat tcattatggg caaaaccatt     1800

gaatttcaca tgggtggtaa tatggagtta aaggcggaaa acagtatcat cctaaatgga     1860

tctgtgatgg tcagcaccac ccgcctaccc agttcctcca gtggagacca gttgggtagt     1920

ggtgactggg tacgctacaa gctctgcatg tgtgctgatg ggacgctctt caaggtgcaa     1980

gtaaccagcc agaacatggg ctgccaaatc tcagacaacc cctgtggaaa cactcattaa     2040

ttcgaaacgt tcggtccatc ttgagcatct gacttctggc taaataaaag atctttattt     2100

tcattagatc tgtgtgttgg ttttttgtgt gcgtcgagat ccacggccgc aggaacccct     2160

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     2220

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     2280

ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     2340

ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt     2400

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     2460

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     2520

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     2580

ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     2640

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     2700

atctcgggct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     2760

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt     2820

ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac     2880

ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga     2940

caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa     3000

cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     3060

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     3120

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     3180

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     3240

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     3300

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     3360

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     3420

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     3480

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     3540

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     3600

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     3660

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     3720

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     3780

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     3840

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     3900

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     3960

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     4020

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     4080

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     4140

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     4200

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     4260

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     4320

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     4380

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     4440

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     4500

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     4560

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     4620

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     4680

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     4740

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     4800

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     4860

gccttttgct ggccttttgc tc                                              4882


<210>  23
<211>  5323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccacgc      600

gtcagtttac tcaccaggga ttcagaggca gcactgctga accctgagcc cttggcacat      660

caggttggct gtcagaagtc ggcctttgta catacacagt tcccttgtga ggcccagctg      720

cgtgtcctag gagcggggcc tctctccaca gcagagctca gcctctcaag tgtatggaca      780

gcacgggtgc ctgatgggtg gatttagcca tgagttgaag gtggcttggg gagaatgaga      840

gttctagaga tagggagaag gggttgccaa taggagagtg gaattcctga gcacctcgtc      900

acaggcagcc gacagaacat gagccgcagg gcccaggcta tttatacctc gcctgtcact      960

atcagggtcc ccacagctcc ccccacctcc agccacacac agcaggtcct tttgctcttt     1020

ctggtccctt ctctactcct ccccctccct acctaaggta cccaacgcgt tacgtggcca     1080

ccgccttcgg caccatcctc acgacaccca aatatggcga cgggtgagga atggtgggga     1140

gttattttta gagcggtgag gaaggtgggc aggcagcagg tgttggcgct ctaaaaataa     1200

ctcccgggag ttatttttag agcggaggaa tggtggacac ccaaatatgg cgacggttcc     1260

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg     1320

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc     1380

ggaggagcgg gaggcgccaa gctctagatc tagaaagagg taagggttta agggatggtt     1440

ggttggtggg gtattaatgt ttaattacct ggagcacctg cctgaaatca ctttttttca     1500

ggttggaagc ttgccaccat ggctgctgcc gctgctgctg cagctgaaca gcaatctagc     1560

aacggccccg tgaagaaatc catgcgcgag aaggccgtcg agcggagatc tgtgaacaaa     1620

gagcacaaca gcaacttcaa ggccggctac atccccatcg acgaggacag actgcacaag     1680

acaggcctga gaggcagaaa gggcaatctg gccatctgcg tgatcatcct gctgttcatc     1740

ctggccgtga tcaacctgat catcaccctg gtcatctggg ccgtgattag aatcggcccc     1800

aacggctgcg acagcatgga atttcacgag agcggcctgc tgcggttcaa acaggtgtcc     1860

gatatgggcg tgatccatcc actgtacaag agcaccgttg gcggcagaag aaacgagaat     1920

ctggtcatca ccggcaacaa ccagcctatc gtgtttcagc agggcaccac caagctgagc     1980

gtggaaaaca acaagaccag catcaccagc gacatcggca tgcagttctt cgaccccaga     2040

acacagaaca tcctgttcag caccgactac gagacacacg agttccatct gcctagcggc     2100

gtgaagtccc tgaatgtgca gaaggccagc accgagagaa tcaccagcaa tgccacctcc     2160

gacctgaaca tcaaagtgga cggcagagcc atcgtgcggg gaaatgaggg cgtgttcatc     2220

atgggcaaga ccatcgagtt ccacatgggc ggcaacatgg aactgaaggc cgagaacagc     2280

atcatcctga acggcagcgt gatggtgtcc accacaagac tgccaagcag cagctctggc     2340

gatcagcttg gatctggcga ctgggtccga tacaagctgt gtatgtgtgc cgacggcacc     2400

ctgttcaagg tgcaagtgac aagccagaac atgggctgcc agatcagcga caacccttgc     2460

ggcaataccc actgattcga aacgtcaagt ccatcttgag catctgactt ctggctaaat     2520

aaaagatctt tattttcatt agatctgtgt gttggttttt tgtgtgcgtc gagatccacg     2580

gccgcaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     2640

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     2700

cgagcgagcg cgcagctgcc tgcaggggcg cctgatgcgg tattttctcc ttacgcatct     2760

gtgcggtatt tcacaccgca tacgtcaaag caaccatagt acgcgccctg tagcggcgca     2820

ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta     2880

gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt     2940

caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac     3000

cccaaaaaac ttgatttggg tgatggttca cgtagtgggc catcgccctg atagacggtt     3060

tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga     3120

acaacactca accctatctc gggctattct tttgatttat aagggatttt gccgatttcg     3180

gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata     3240

ttaacgttta caattttatg gtgcactctc agtacaatct gctctgatgc cgcatagtta     3300

agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg     3360

gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca     3420

ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt     3480

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     3540

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     3600

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     3660

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     3720

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     3780

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     3840

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa     3900

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     3960

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     4020

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     4080

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     4140

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca     4200

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     4260

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     4320

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     4380

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     4440

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     4500

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     4560

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     4620

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     4680

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     4740

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     4800

gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac     4860

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     4920

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     4980

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     5040

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     5100

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     5160

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     5220

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     5280

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgt                       5323


<210>  24
<211>  5391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE04-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  24
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gcccctttta gagaatccac acctgtccca      180

gttgctgggt tccactacca aaagtgaatt gcaactattt taggagcact taagcacatc      240

cgaaaaatga gtgattctgt tctggcccac accacatcac tgatgtaccc ccttaaagca      300

tgtccctgag ttcatcacag aagactgctc ctcctgtgcc ctccacaagg ttagaactgt      360

ccttgtctta gggaaaaagg agagagagag agagagagag agagagagag agagagagag      420

agagagagag ggacaggcac caactgggta acctctgctg acccccactc tactttacca      480

taagtagctc caaatccttc tagaaaatct gaaaggcata gccccatata tcagtgatat      540

aaatagaacc tgcagcaggc tctggtaaat gatgactaca aggtggactg ggaggcagcc      600

cggccttggc aggcatcatc ctctaaatat aaagatgagt ttgttcagcc tttgcagaag      660

gaggcgcgcc acgcgtcagt ttactcacca gggattcaga ggcagcactg ctgaaccctg      720

agcccttggc acatcaggtt ggctgtcaga agtcggcctt tgtacataca cagttccctt      780

gtgaggccca gctgcgtgtc ctaggagcgg ggcctctctc cacagcagag ctcagcctct      840

caagtgtatg gacagcacgg gtgcctgatg ggtggattta gccatgagtt gaaggtggct      900

tggggagaat gagagttcta gagataggga gaaggggttg ccaataggag agtggaattc      960

ctgagcacct cgtcacaggc agccgacaga acatgagccg cagggcccag gctatttata     1020

cctcgcctgt cactatcagg gtccccacag ctccccccac ctccagccac acacagcagg     1080

tccttttgct ctttctggtc ccttctctac tcctccccct ccctacctaa ggtacccaac     1140

gcgttacgtg gccaccgcct tcggcaccat cctcacgaca cccaaatatg gcgacgggtg     1200

aggaatggtg gggagttatt tttagagcgg tgaggaaggt gggcaggcag caggtgttgg     1260

cgctctaaaa ataactcccg ggagttattt ttagagcgga ggaatggtgg acacccaaat     1320

atggcgacgg ttcctcaccc gtcgccatat ttgggtgtcc gccctcggcc ggggccgcat     1380

tcctgggggc cgggcggtgc tcccgcccgc ctcgataaaa ggctccgggg ccggcggcgg     1440

cccacgagct acccggagga gcgggaggcg ccaagctcta gatctagaaa gaggtaaggg     1500

tttaagggat ggttggttgg tggggtatta atgtttaatt acctggagca cctgcctgaa     1560

atcacttttt ttcaggttgg aagcttgcca ccatggctgc tgccgctgct gctgcagctg     1620

aacagcaatc tagcaacggc cccgtgaaga aatccatgcg cgagaaggcc gtcgagcgga     1680

gatctgtgaa caaagagcac aacagcaact tcaaggccgg ctacatcccc atcgacgagg     1740

acagactgca caagacaggc ctgagaggca gaaagggcaa tctggccatc tgcgtgatca     1800

tcctgctgtt catcctggcc gtgatcaacc tgatcatcac cctggtcatc tgggccgtga     1860

ttagaatcgg ccccaacggc tgcgacagca tggaatttca cgagagcggc ctgctgcggt     1920

tcaaacaggt gtccgatatg ggcgtgatcc atccactgta caagagcacc gttggcggca     1980

gaagaaacga gaatctggtc atcaccggca acaaccagcc tatcgtgttt cagcagggca     2040

ccaccaagct gagcgtggaa aacaacaaga ccagcatcac cagcgacatc ggcatgcagt     2100

tcttcgaccc cagaacacag aacatcctgt tcagcaccga ctacgagaca cacgagttcc     2160

atctgcctag cggcgtgaag tccctgaatg tgcagaaggc cagcaccgag agaatcacca     2220

gcaatgccac ctccgacctg aacatcaaag tggacggcag agccatcgtg cggggaaatg     2280

agggcgtgtt catcatgggc aagaccatcg agttccacat gggcggcaac atggaactga     2340

aggccgagaa cagcatcatc ctgaacggca gcgtgatggt gtccaccaca agactgccaa     2400

gcagcagctc tggcgatcag cttggatctg gcgactgggt ccgatacaag ctgtgtatgt     2460

gtgccgacgg caccctgttc aaggtgcaag tgacaagcca gaacatgggc tgccagatca     2520

gcgacaaccc ttgcggcaat acccactgat tcgaaacgtc acgtccatct tgagcatctg     2580

acttctggct aaataaaaga tctttatttt cattagatct gtgtgttggt tttttgtgtg     2640

cgtcgagatc cacggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc     2700

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     2760

gcggcctcag tgagcgagcg agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt     2820

ctccttacgc atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc     2880

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     2940

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     3000

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     3060

tacggcacct cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc     3120

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     3180

tgttccaaac tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga     3240

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     3300

attttaacaa aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg     3360

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     3420

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     3480

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc     3540

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc     3600

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     3660

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     3720

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     3780

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     3840

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     3900

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     3960

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     4020

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     4080

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     4140

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     4200

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     4260

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     4320

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     4380

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     4440

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     4500

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     4560

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     4620

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     4680

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     4740

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     4800

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     4860

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc     4920

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     4980

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     5040

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     5100

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     5160

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     5220

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     5280

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     5340

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct c              5391


<210>  25
<211>  5271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE06-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  25
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgggc caggggacgg tggcttctac gtgcttggga cgttcccagc      180

caccgtccca tgttcccggc ggggggccag ctgtccccac cgccagccca actcagcact      240

tggtcagggt atcagcttgg tgggggggcg tgagcccagc ccctggggcg gctcagccca      300

tacaaggcca tggggctggg cgcaaagcat gcctgggttc agggtgggta tggtgcggga      360

gcagggaggt gagaggctca gctgccctcc agaactcctc cctggggaca acccctccca      420

gccaatagca cagcctaggt ccccctatat aaggccacgg ctgctggccc ttcctttggg      480

tcagtgtcac ctccaggata cagacagccc cccttcagcc cagcccagcc aggtacggcg      540

cgccacgcgt cagtttactc accagggatt cagaggcagc actgctgaac cctgagccct      600

tggcacatca ggttggctgt cagaagtcgg cctttgtaca tacacagttc ccttgtgagg      660

cccagctgcg tgtcctagga gcggggcctc tctccacagc agagctcagc ctctcaagtg      720

tatggacagc acgggtgcct gatgggtgga tttagccatg agttgaaggt ggcttgggga      780

gaatgagagt tctagagata gggagaaggg gttgccaata ggagagtgga attcctgagc      840

acctcgtcac aggcagccga cagaacatga gccgcagggc ccaggctatt tatacctcgc      900

ctgtcactat cagggtcccc acagctcccc ccacctccag ccacacacag caggtccttt      960

tgctctttct ggtcccttct ctactcctcc ccctccctac ctaaggtacc caacgcgtta     1020

cgtggccacc gccttcggca ccatcctcac gacacccaaa tatggcgacg ggtgaggaat     1080

ggtggggagt tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct     1140

aaaaataact cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg     1200

acggttcctc acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg     1260

gggccgggcg gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg     1320

agctacccgg aggagcggga ggcgccaagc tctagatcta gaaagaggta agggtttaag     1380

ggatggttgg ttggtggggt attaatgttt aattacctgg agcacctgcc tgaaatcact     1440

ttttttcagg ttggaagctt gccaccatgg ctgctgccgc tgctgctgca gctgaacagc     1500

aatctagcaa cggccccgtg aagaaatcca tgcgcgagaa ggccgtcgag cggagatctg     1560

tgaacaaaga gcacaacagc aacttcaagg ccggctacat ccccatcgac gaggacagac     1620

tgcacaagac aggcctgaga ggcagaaagg gcaatctggc catctgcgtg atcatcctgc     1680

tgttcatcct ggccgtgatc aacctgatca tcaccctggt catctgggcc gtgattagaa     1740

tcggccccaa cggctgcgac agcatggaat ttcacgagag cggcctgctg cggttcaaac     1800

aggtgtccga tatgggcgtg atccatccac tgtacaagag caccgttggc ggcagaagaa     1860

acgagaatct ggtcatcacc ggcaacaacc agcctatcgt gtttcagcag ggcaccacca     1920

agctgagcgt ggaaaacaac aagaccagca tcaccagcga catcggcatg cagttcttcg     1980

accccagaac acagaacatc ctgttcagca ccgactacga gacacacgag ttccatctgc     2040

ctagcggcgt gaagtccctg aatgtgcaga aggccagcac cgagagaatc accagcaatg     2100

ccacctccga cctgaacatc aaagtggacg gcagagccat cgtgcgggga aatgagggcg     2160

tgttcatcat gggcaagacc atcgagttcc acatgggcgg caacatggaa ctgaaggccg     2220

agaacagcat catcctgaac ggcagcgtga tggtgtccac cacaagactg ccaagcagca     2280

gctctggcga tcagcttgga tctggcgact gggtccgata caagctgtgt atgtgtgccg     2340

acggcaccct gttcaaggtg caagtgacaa gccagaacat gggctgccag atcagcgaca     2400

acccttgcgg caatacccac tgattcgaaa cgtctagtcc atcttgagca tctgacttct     2460

ggctaaataa aagatcttta ttttcattag atctgtgtgt tggttttttg tgtgcgtcga     2520

gatccacggc cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     2580

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     2640

tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt     2700

acgcatctgt gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta     2760

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     2820

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     2880

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     2940

acctcgaccc caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat     3000

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     3060

aaactggaac aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc     3120

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     3180

acaaaatatt aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg     3240

catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     3300

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     3360

ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt     3420

tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa     3480

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     3540

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     3600

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     3660

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     3720

acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt     3780

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     3840

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     3900

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     3960

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     4020

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     4080

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa     4140

tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     4200

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     4260

cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca     4320

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     4380

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     4440

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     4500

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     4560

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     4620

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     4680

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     4740

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     4800

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     4860

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     4920

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     4980

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     5040

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     5100

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     5160

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     5220

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg t              5271


<210>  26
<211>  5864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  26
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatcccc ttttagagaa tccacacctg tcccagttgc tgggttccac taccaaaagt      660

gaattgcaac tattttagga gcacttaagc acatccgaaa aatgagtgat tctgttctgg      720

cccacaccac atcactgatg taccccctta aagcatgtcc ctgagttcat cacagaagac      780

tgctcctcct gtgccctcca caaggttaga actgtccttg tcttagggaa aaaggagaga      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagggaca ggcaccaact      900

gggtaacctc tgctgacccc cactctactt taccataagt agctccaaat ccttctagaa      960

aatctgaaag gcatagcccc atatatcagt gatataaata gaacctgcag caggctctgg     1020

taaatgatga ctacaaggtg gactgggagg cagcccggcc ttggcaggca tcatcctcta     1080

aatataaaga tgagtttgtt cagcctttgc agaaggagga tccgtcgacg gcgcgccacg     1140

cgtcagttta ctcaccaggg attcagaggc agcactgctg aaccctgagc ccttggcaca     1200

tcaggttggc tgtcagaagt cggcctttgt acatacacag ttcccttgtg aggcccagct     1260

gcgtgtccta ggagcggggc ctctctccac agcagagctc agcctctcaa gtgtatggac     1320

agcacgggtg cctgatgggt ggatttagcc atgagttgaa ggtggcttgg ggagaatgag     1380

agttctagag atagggagaa ggggttgcca ataggagagt ggaattcctg agcacctcgt     1440

cacaggcagc cgacagaaca tgagccgcag ggcccaggct atttatacct cgcctgtcac     1500

tatcagggtc cccacagctc cccccacctc cagccacaca cagcaggtcc ttttgctctt     1560

tctggtccct tctctactcc tccccctccc tacctaaggt acccaacgcg ttacgtggcc     1620

accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg aatggtgggg     1680

agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc tctaaaaata     1740

actcccggga gttattttta gagcggagga atggtggaca cccaaatatg gcgacggttc     1800

ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg     1860

gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc acgagctacc     1920

cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt aagggatggt     1980

tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc     2040

aggttggaag cttgccacca tggctgctgc cgctgctgct gcagctgaac agcaatctag     2100

caacggcccc gtgaagaaat ccatgcgcga gaaggccgtc gagcggagat ctgtgaacaa     2160

agagcacaac agcaacttca aggccggcta catccccatc gacgaggaca gactgcacaa     2220

gacaggcctg agaggcagaa agggcaatct ggccatctgc gtgatcatcc tgctgttcat     2280

cctggccgtg atcaacctga tcatcaccct ggtcatctgg gccgtgatta gaatcggccc     2340

caacggctgc gacagcatgg aatttcacga gagcggcctg ctgcggttca aacaggtgtc     2400

cgatatgggc gtgatccatc cactgtacaa gagcaccgtt ggcggcagaa gaaacgagaa     2460

tctggtcatc accggcaaca accagcctat cgtgtttcag cagggcacca ccaagctgag     2520

cgtggaaaac aacaagacca gcatcaccag cgacatcggc atgcagttct tcgaccccag     2580

aacacagaac atcctgttca gcaccgacta cgagacacac gagttccatc tgcctagcgg     2640

cgtgaagtcc ctgaatgtgc agaaggccag caccgagaga atcaccagca atgccacctc     2700

cgacctgaac atcaaagtgg acggcagagc catcgtgcgg ggaaatgagg gcgtgttcat     2760

catgggcaag accatcgagt tccacatggg cggcaacatg gaactgaagg ccgagaacag     2820

catcatcctg aacggcagcg tgatggtgtc caccacaaga ctgccaagca gcagctctgg     2880

cgatcagctt ggatctggcg actgggtccg atacaagctg tgtatgtgtg ccgacggcac     2940

cctgttcaag gtgcaagtga caagccagaa catgggctgc cagatcagcg acaacccttg     3000

cggcaatacc cactgattcg aaacgtcaag tccatcttga gcatctgact tctggctaaa     3060

taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtgcgt cgagatccac     3120

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3180

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3240

gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc cttacgcatc     3300

tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc     3360

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     3420

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     3480

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     3540

ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct gatagacggt     3600

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     3660

aacaacactc aaccctatct cgggctattc ttttgattta taagggattt tgccgatttc     3720

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     3780

attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     3840

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     3900

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     3960

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4020

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     4080

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     4140

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     4200

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     4260

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4320

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4380

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     4440

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     4500

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     4560

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     4620

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     4680

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     4740

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     4800

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     4860

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     4920

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     4980

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     5040

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     5100

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     5160

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     5220

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     5280

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5340

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     5400

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     5460

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     5520

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     5580

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     5640

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     5700

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     5760

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     5820

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgt                      5864


<210>  27
<211>  5864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  27
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatcccc ttttagagaa tccacacctg tcccagttgc tgggttccac taccaaaagt      660

gaattgcaac tattttagga gcacttaagc acatccgaaa aatgagtgat tctgttctgg      720

cccacaccac atcactgatg taccccctta aagcatgtcc ctgagttcat cacagaagac      780

tgctcctcct gtgccctcca caaggttaga actgtccttg tcttagggaa aaaggagaga      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagggaca ggcaccaact      900

gggtaacctc tgctgacccc cactctactt taccataagt agctccaaat ccttctagaa      960

aatctgaaag gcatagcccc atatatcagt gatataaata gaacctgcag caggctctgg     1020

taaatgatga ctacaaggtg gactgggagg cagcccggcc ttggcaggca tcatcctcta     1080

aatataaaga tgagtttgtt cagcctttgc agaaggagga tccgtcgacg gcgcgccacg     1140

cgtcagttta ctcaccaggg attcagaggc agcactgctg aaccctgagc ccttggcaca     1200

tcaggttggc tgtcagaagt cggcctttgt acatacacag ttcccttgtg aggcccagct     1260

gcgtgtccta ggagcggggc ctctctccac agcagagctc agcctctcaa gtgtatggac     1320

agcacgggtg cctgatgggt ggatttagcc atgagttgaa ggtggcttgg ggagaatgag     1380

agttctagag atagggagaa ggggttgcca ataggagagt ggaattcctg agcacctcgt     1440

cacaggcagc cgacagaaca tgagccgcag ggcccaggct atttatacct cgcctgtcac     1500

tatcagggtc cccacagctc cccccacctc cagccacaca cagcaggtcc ttttgctctt     1560

tctggtccct tctctactcc tccccctccc tacctaaggt acccaacgcg ttacgtggcc     1620

accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg aatggtgggg     1680

agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc tctaaaaata     1740

actcccggga gttattttta gagcggagga atggtggaca cccaaatatg gcgacggttc     1800

ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg     1860

gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc acgagctacc     1920

cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt aagggatggt     1980

tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc     2040

aggttggaag cttgccacca tggcggcagc ggcggcggcg gctgcagaac agcaaagttc     2100

caatggtcct gtaaagaagt ccatgcgtga gaaggctgtt gagagaagga gtgtcaataa     2160

agagcacaac agtaacttta aagctggata cattccgatt gatgaagatc gtctccacaa     2220

aacagggttg agaggaagaa agggcaattt agccatctgt gtgattatcc tcttgtttat     2280

cctggctgtc atcaatttaa taataacact tgttatttgg gccgtgattc gcattggacc     2340

aaatggctgt gatagtatgg agtttcatga aagtggcctg cttcgattta agcaagtatc     2400

tgacatggga gtgatccacc ctctttataa aagcacagta ggaggaaggc gaaatgaaaa     2460

tttggtcatc actggcaaca accagcctat tgtttttcag caagggacaa caaagctcag     2520

tgtagaaaac aacaaaactt ctattacaag tgacatcggc atgcagtttt ttgacccgag     2580

gactcaaaat atcttattca gcacagacta tgaaactcat gagtttcatt tgccaagtgg     2640

agtgaaaagt ttgaatgttc aaaaggcatc tactgaaagg attaccagca atgctaccag     2700

tgatttaaat ataaaagttg atgggcgtgc tattgtgcgt ggaaatgaag gtgtattcat     2760

tatgggcaaa accattgaat ttcacatggg tggtaatatg gagttaaagg cggaaaacag     2820

tatcatccta aatggatctg tgatggtcag caccacccgc ctacccagtt cctccagtgg     2880

agaccagttg ggtagtggtg actgggtacg ctacaagctc tgcatgtgtg ctgatgggac     2940

gctcttcaag gtgcaagtaa ccagccagaa catgggctgc caaatctcag acaacccctg     3000

tggaaacact cattaattcg aaacgtcaag tccatcttga gcatctgact tctggctaaa     3060

taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtgcgt cgagatccac     3120

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3180

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3240

gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc cttacgcatc     3300

tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc     3360

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     3420

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     3480

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     3540

ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct gatagacggt     3600

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     3660

aacaacactc aaccctatct cgggctattc ttttgattta taagggattt tgccgatttc     3720

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     3780

attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     3840

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     3900

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     3960

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4020

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     4080

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     4140

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     4200

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     4260

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4320

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4380

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     4440

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     4500

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     4560

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     4620

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     4680

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     4740

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     4800

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     4860

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     4920

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     4980

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     5040

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     5100

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     5160

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     5220

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     5280

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5340

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     5400

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     5460

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     5520

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     5580

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     5640

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     5700

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     5760

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     5820

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgt                      5864


<210>  28
<211>  5823
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  28
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gcccctttta gagaatccac acctgtccca      180

gttgctgggt tccactacca aaagtgaatt gcaactattt taggagcact taagcacatc      240

cgaaaaatga gtgattctgt tctggcccac accacatcac tgatgtaccc ccttaaagca      300

tgtccctgag ttcatcacag aagactgctc ctcctgtgcc ctccacaagg ttagaactgt      360

ccttgtctta gggaaaaagg agagagagag agagagagag agagagagag agagagagag      420

agagagagag ggacaggcac caactgggta acctctgctg acccccactc tactttacca      480

taagtagctc caaatccttc tagaaaatct gaaaggcata gccccatata tcagtgatat      540

aaatagaacc tgcagcaggc tctggtaaat gatgactaca aggtggactg ggaggcagcc      600

cggccttggc aggcatcatc ctctaaatat aaagatgagt ttgttcagcc tttgcagaag      660

gaggcgcgcc gtcgacggat ccgggccagg ggacggtggc ttctacgtgc ttgggacgtt      720

cccagccacc gtcccatgtt cccggcgggg ggccagctgt ccccaccgcc agcccaactc      780

agcacttggt cagggtatca gcttggtggg ggggcgtgag cccagcccct ggggcggctc      840

agcccataca aggccatggg gctgggcgca aagcatgcct gggttcaggg tgggtatggt      900

gcgggagcag ggaggtgaga ggctcagctg ccctccagaa ctcctccctg gggacaaccc      960

ctcccagcca atagcacagc ctaggtcccc ctatataagg ccacggctgc tggcccttcc     1020

tttgggtcag tgtcacctcc aggatacaga cagcccccct tcagcccagc ccagccaggt     1080

acggatccgt cgacggcgcg ccacgcgtca gtttactcac cagggattca gaggcagcac     1140

tgctgaaccc tgagcccttg gcacatcagg ttggctgtca gaagtcggcc tttgtacata     1200

cacagttccc ttgtgaggcc cagctgcgtg tcctaggagc ggggcctctc tccacagcag     1260

agctcagcct ctcaagtgta tggacagcac gggtgcctga tgggtggatt tagccatgag     1320

ttgaaggtgg cttggggaga atgagagttc tagagatagg gagaaggggt tgccaatagg     1380

agagtggaat tcctgagcac ctcgtcacag gcagccgaca gaacatgagc cgcagggccc     1440

aggctattta tacctcgcct gtcactatca gggtccccac agctcccccc acctccagcc     1500

acacacagca ggtccttttg ctctttctgg tcccttctct actcctcccc ctccctacct     1560

aaggtaccca acgcgttacg tggccaccgc cttcggcacc atcctcacga cacccaaata     1620

tggcgacggg tgaggaatgg tggggagtta tttttagagc ggtgaggaag gtgggcaggc     1680

agcaggtgtt ggcgctctaa aaataactcc cgggagttat ttttagagcg gaggaatggt     1740

ggacacccaa atatggcgac ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg     1800

ccggggccgc attcctgggg gccgggcggt gctcccgccc gcctcgataa aaggctccgg     1860

ggccggcggc ggcccacgag ctacccggag gagcgggagg cgccaagctc tagatctaga     1920

aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag     1980

cacctgcctg aaatcacttt ttttcaggtt ggaagcttgc caccatggct gctgccgctg     2040

ctgctgcagc tgaacagcaa tctagcaacg gccccgtgaa gaaatccatg cgcgagaagg     2100

ccgtcgagcg gagatctgtg aacaaagagc acaacagcaa cttcaaggcc ggctacatcc     2160

ccatcgacga ggacagactg cacaagacag gcctgagagg cagaaagggc aatctggcca     2220

tctgcgtgat catcctgctg ttcatcctgg ccgtgatcaa cctgatcatc accctggtca     2280

tctgggccgt gattagaatc ggccccaacg gctgcgacag catggaattt cacgagagcg     2340

gcctgctgcg gttcaaacag gtgtccgata tgggcgtgat ccatccactg tacaagagca     2400

ccgttggcgg cagaagaaac gagaatctgg tcatcaccgg caacaaccag cctatcgtgt     2460

ttcagcaggg caccaccaag ctgagcgtgg aaaacaacaa gaccagcatc accagcgaca     2520

tcggcatgca gttcttcgac cccagaacac agaacatcct gttcagcacc gactacgaga     2580

cacacgagtt ccatctgcct agcggcgtga agtccctgaa tgtgcagaag gccagcaccg     2640

agagaatcac cagcaatgcc acctccgacc tgaacatcaa agtggacggc agagccatcg     2700

tgcggggaaa tgagggcgtg ttcatcatgg gcaagaccat cgagttccac atgggcggca     2760

acatggaact gaaggccgag aacagcatca tcctgaacgg cagcgtgatg gtgtccacca     2820

caagactgcc aagcagcagc tctggcgatc agcttggatc tggcgactgg gtccgataca     2880

agctgtgtat gtgtgccgac ggcaccctgt tcaaggtgca agtgacaagc cagaacatgg     2940

gctgccagat cagcgacaac ccttgcggca atacccactg attcgaaacg tcacgtccat     3000

cttgagcatc tgacttctgg ctaaataaaa gatctttatt ttcattagat ctgtgtgttg     3060

gttttttgtg tgcgtcgaga tccacggccg caggaacccc tagtgatgga gttggccact     3120

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     3180

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg     3240

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac     3300

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     3360

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     3420

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     3480

gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta     3540

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     3600

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcgggc tattcttttg     3660

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     3720

aatttaacgc gaattttaac aaaatattaa cgtttacaat tttatggtgc actctcagta     3780

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg     3840

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     3900

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     3960

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     4020

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     4080

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa     4140

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4200

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4260

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4320

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     4380

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     4440

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     4500

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     4560

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     4620

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     4680

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     4740

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     4800

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     4860

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     4920

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     4980

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5040

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5100

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5160

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5220

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5280

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     5340

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     5400

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     5460

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     5520

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     5580

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     5640

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     5700

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     5760

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     5820

ctc                                                                   5823


<210>  29
<211>  5823
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  29
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gcccctttta gagaatccac acctgtccca      180

gttgctgggt tccactacca aaagtgaatt gcaactattt taggagcact taagcacatc      240

cgaaaaatga gtgattctgt tctggcccac accacatcac tgatgtaccc ccttaaagca      300

tgtccctgag ttcatcacag aagactgctc ctcctgtgcc ctccacaagg ttagaactgt      360

ccttgtctta gggaaaaagg agagagagag agagagagag agagagagag agagagagag      420

agagagagag ggacaggcac caactgggta acctctgctg acccccactc tactttacca      480

taagtagctc caaatccttc tagaaaatct gaaaggcata gccccatata tcagtgatat      540

aaatagaacc tgcagcaggc tctggtaaat gatgactaca aggtggactg ggaggcagcc      600

cggccttggc aggcatcatc ctctaaatat aaagatgagt ttgttcagcc tttgcagaag      660

gaggcgcgcc gtcgacggat ccgggccagg ggacggtggc ttctacgtgc ttgggacgtt      720

cccagccacc gtcccatgtt cccggcgggg ggccagctgt ccccaccgcc agcccaactc      780

agcacttggt cagggtatca gcttggtggg ggggcgtgag cccagcccct ggggcggctc      840

agcccataca aggccatggg gctgggcgca aagcatgcct gggttcaggg tgggtatggt      900

gcgggagcag ggaggtgaga ggctcagctg ccctccagaa ctcctccctg gggacaaccc      960

ctcccagcca atagcacagc ctaggtcccc ctatataagg ccacggctgc tggcccttcc     1020

tttgggtcag tgtcacctcc aggatacaga cagcccccct tcagcccagc ccagccaggt     1080

acggatccgt cgacggcgcg ccacgcgtca gtttactcac cagggattca gaggcagcac     1140

tgctgaaccc tgagcccttg gcacatcagg ttggctgtca gaagtcggcc tttgtacata     1200

cacagttccc ttgtgaggcc cagctgcgtg tcctaggagc ggggcctctc tccacagcag     1260

agctcagcct ctcaagtgta tggacagcac gggtgcctga tgggtggatt tagccatgag     1320

ttgaaggtgg cttggggaga atgagagttc tagagatagg gagaaggggt tgccaatagg     1380

agagtggaat tcctgagcac ctcgtcacag gcagccgaca gaacatgagc cgcagggccc     1440

aggctattta tacctcgcct gtcactatca gggtccccac agctcccccc acctccagcc     1500

acacacagca ggtccttttg ctctttctgg tcccttctct actcctcccc ctccctacct     1560

aaggtaccca acgcgttacg tggccaccgc cttcggcacc atcctcacga cacccaaata     1620

tggcgacggg tgaggaatgg tggggagtta tttttagagc ggtgaggaag gtgggcaggc     1680

agcaggtgtt ggcgctctaa aaataactcc cgggagttat ttttagagcg gaggaatggt     1740

ggacacccaa atatggcgac ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg     1800

ccggggccgc attcctgggg gccgggcggt gctcccgccc gcctcgataa aaggctccgg     1860

ggccggcggc ggcccacgag ctacccggag gagcgggagg cgccaagctc tagatctaga     1920

aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag     1980

cacctgcctg aaatcacttt ttttcaggtt ggaagcttgc caccatggcg gcagcggcgg     2040

cggcggctgc agaacagcaa agttccaatg gtcctgtaaa gaagtccatg cgtgagaagg     2100

ctgttgagag aaggagtgtc aataaagagc acaacagtaa ctttaaagct ggatacattc     2160

cgattgatga agatcgtctc cacaaaacag ggttgagagg aagaaagggc aatttagcca     2220

tctgtgtgat tatcctcttg tttatcctgg ctgtcatcaa tttaataata acacttgtta     2280

tttgggccgt gattcgcatt ggaccaaatg gctgtgatag tatggagttt catgaaagtg     2340

gcctgcttcg atttaagcaa gtatctgaca tgggagtgat ccaccctctt tataaaagca     2400

cagtaggagg aaggcgaaat gaaaatttgg tcatcactgg caacaaccag cctattgttt     2460

ttcagcaagg gacaacaaag ctcagtgtag aaaacaacaa aacttctatt acaagtgaca     2520

tcggcatgca gttttttgac ccgaggactc aaaatatctt attcagcaca gactatgaaa     2580

ctcatgagtt tcatttgcca agtggagtga aaagtttgaa tgttcaaaag gcatctactg     2640

aaaggattac cagcaatgct accagtgatt taaatataaa agttgatggg cgtgctattg     2700

tgcgtggaaa tgaaggtgta ttcattatgg gcaaaaccat tgaatttcac atgggtggta     2760

atatggagtt aaaggcggaa aacagtatca tcctaaatgg atctgtgatg gtcagcacca     2820

cccgcctacc cagttcctcc agtggagacc agttgggtag tggtgactgg gtacgctaca     2880

agctctgcat gtgtgctgat gggacgctct tcaaggtgca agtaaccagc cagaacatgg     2940

gctgccaaat ctcagacaac ccctgtggaa acactcatta attcgaaacg tcacgtccat     3000

cttgagcatc tgacttctgg ctaaataaaa gatctttatt ttcattagat ctgtgtgttg     3060

gttttttgtg tgcgtcgaga tccacggccg caggaacccc tagtgatgga gttggccact     3120

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     3180

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gctgcctgca ggggcgcctg     3240

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatacg tcaaagcaac     3300

catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     3360

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     3420

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     3480

gatttagtgc tttacggcac ctcgacccca aaaaacttga tttgggtgat ggttcacgta     3540

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     3600

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcgggc tattcttttg     3660

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     3720

aatttaacgc gaattttaac aaaatattaa cgtttacaat tttatggtgc actctcagta     3780

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg     3840

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg     3900

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc     3960

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag     4020

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     4080

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa     4140

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt     4200

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt     4260

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt     4320

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg     4380

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga     4440

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa     4500

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga     4560

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa     4620

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca     4680

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta     4740

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac     4800

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc     4860

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag     4920

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga     4980

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt     5040

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata     5100

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag     5160

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa     5220

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt     5280

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc     5340

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa     5400

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa     5460

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc     5520

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa     5580

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa     5640

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg     5700

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc     5760

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg     5820

ctc                                                                   5823


<210>  30
<211>  5812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE06-CRE04-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  30
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgggc caggggacgg tggcttctac gtgcttggga cgttcccagc      180

caccgtccca tgttcccggc ggggggccag ctgtccccac cgccagccca actcagcact      240

tggtcagggt atcagcttgg tgggggggcg tgagcccagc ccctggggcg gctcagccca      300

tacaaggcca tggggctggg cgcaaagcat gcctgggttc agggtgggta tggtgcggga      360

gcagggaggt gagaggctca gctgccctcc agaactcctc cctggggaca acccctccca      420

gccaatagca cagcctaggt ccccctatat aaggccacgg ctgctggccc ttcctttggg      480

tcagtgtcac ctccaggata cagacagccc cccttcagcc cagcccagcc aggtacggcg      540

cgccgtcgac ggatcccctt ttagagaatc cacacctgtc ccagttgctg ggttccacta      600

ccaaaagtga attgcaacta ttttaggagc acttaagcac atccgaaaaa tgagtgattc      660

tgttctggcc cacaccacat cactgatgta cccccttaaa gcatgtccct gagttcatca      720

cagaagactg ctcctcctgt gccctccaca aggttagaac tgtccttgtc ttagggaaaa      780

aggagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagggacagg      840

caccaactgg gtaacctctg ctgaccccca ctctacttta ccataagtag ctccaaatcc      900

ttctagaaaa tctgaaaggc atagccccat atatcagtga tataaataga acctgcagca      960

ggctctggta aatgatgact acaaggtgga ctgggaggca gcccggcctt ggcaggcatc     1020

atcctctaaa tataaagatg agtttgttca gcctttgcag aaggaggatc cgtcgacggc     1080

gcgccacgcg tcagtttact caccagggat tcagaggcag cactgctgaa ccctgagccc     1140

ttggcacatc aggttggctg tcagaagtcg gcctttgtac atacacagtt cccttgtgag     1200

gcccagctgc gtgtcctagg agcggggcct ctctccacag cagagctcag cctctcaagt     1260

gtatggacag cacgggtgcc tgatgggtgg atttagccat gagttgaagg tggcttgggg     1320

agaatgagag ttctagagat agggagaagg ggttgccaat aggagagtgg aattcctgag     1380

cacctcgtca caggcagccg acagaacatg agccgcaggg cccaggctat ttatacctcg     1440

cctgtcacta tcagggtccc cacagctccc cccacctcca gccacacaca gcaggtcctt     1500

ttgctctttc tggtcccttc tctactcctc cccctcccta cctaaggtac ccaacgcgtt     1560

acgtggccac cgccttcggc accatcctca cgacacccaa atatggcgac gggtgaggaa     1620

tggtggggag ttatttttag agcggtgagg aaggtgggca ggcagcaggt gttggcgctc     1680

taaaaataac tcccgggagt tatttttaga gcggaggaat ggtggacacc caaatatggc     1740

gacggttcct cacccgtcgc catatttggg tgtccgccct cggccggggc cgcattcctg     1800

ggggccgggc ggtgctcccg cccgcctcga taaaaggctc cggggccggc ggcggcccac     1860

gagctacccg gaggagcggg aggcgccaag ctctagatct agaaagaggt aagggtttaa     1920

gggatggttg gttggtgggg tattaatgtt taattacctg gagcacctgc ctgaaatcac     1980

tttttttcag gttggaagct tgccaccatg gctgctgccg ctgctgctgc agctgaacag     2040

caatctagca acggccccgt gaagaaatcc atgcgcgaga aggccgtcga gcggagatct     2100

gtgaacaaag agcacaacag caacttcaag gccggctaca tccccatcga cgaggacaga     2160

ctgcacaaga caggcctgag aggcagaaag ggcaatctgg ccatctgcgt gatcatcctg     2220

ctgttcatcc tggccgtgat caacctgatc atcaccctgg tcatctgggc cgtgattaga     2280

atcggcccca acggctgcga cagcatggaa tttcacgaga gcggcctgct gcggttcaaa     2340

caggtgtccg atatgggcgt gatccatcca ctgtacaaga gcaccgttgg cggcagaaga     2400

aacgagaatc tggtcatcac cggcaacaac cagcctatcg tgtttcagca gggcaccacc     2460

aagctgagcg tggaaaacaa caagaccagc atcaccagcg acatcggcat gcagttcttc     2520

gaccccagaa cacagaacat cctgttcagc accgactacg agacacacga gttccatctg     2580

cctagcggcg tgaagtccct gaatgtgcag aaggccagca ccgagagaat caccagcaat     2640

gccacctccg acctgaacat caaagtggac ggcagagcca tcgtgcgggg aaatgagggc     2700

gtgttcatca tgggcaagac catcgagttc cacatgggcg gcaacatgga actgaaggcc     2760

gagaacagca tcatcctgaa cggcagcgtg atggtgtcca ccacaagact gccaagcagc     2820

agctctggcg atcagcttgg atctggcgac tgggtccgat acaagctgtg tatgtgtgcc     2880

gacggcaccc tgttcaaggt gcaagtgaca agccagaaca tgggctgcca gatcagcgac     2940

aacccttgcg gcaataccca ctgattcgaa acgtctagtc catcttgagc atctgacttc     3000

tggctaaata aaagatcttt attttcatta gatctgtgtg ttggtttttt gtgtgcgtcg     3060

agatccacgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     3120

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     3180

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     3240

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     3300

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     3360

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     3420

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     3480

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     3540

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     3600

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     3660

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     3720

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     3780

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     3840

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     3900

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     3960

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     4020

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     4080

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     4140

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     4200

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     4260

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     4320

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     4380

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     4440

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     4500

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     4560

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     4620

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     4680

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     4740

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     4800

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     4860

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     4920

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     4980

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     5040

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     5100

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     5160

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     5220

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     5280

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     5340

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     5400

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     5460

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     5520

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     5580

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     5640

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     5700

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     5760

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             5812


<210>  31
<211>  5812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE06-CRE04-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  31
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgggc caggggacgg tggcttctac gtgcttggga cgttcccagc      180

caccgtccca tgttcccggc ggggggccag ctgtccccac cgccagccca actcagcact      240

tggtcagggt atcagcttgg tgggggggcg tgagcccagc ccctggggcg gctcagccca      300

tacaaggcca tggggctggg cgcaaagcat gcctgggttc agggtgggta tggtgcggga      360

gcagggaggt gagaggctca gctgccctcc agaactcctc cctggggaca acccctccca      420

gccaatagca cagcctaggt ccccctatat aaggccacgg ctgctggccc ttcctttggg      480

tcagtgtcac ctccaggata cagacagccc cccttcagcc cagcccagcc aggtacggcg      540

cgccgtcgac ggatcccctt ttagagaatc cacacctgtc ccagttgctg ggttccacta      600

ccaaaagtga attgcaacta ttttaggagc acttaagcac atccgaaaaa tgagtgattc      660

tgttctggcc cacaccacat cactgatgta cccccttaaa gcatgtccct gagttcatca      720

cagaagactg ctcctcctgt gccctccaca aggttagaac tgtccttgtc ttagggaaaa      780

aggagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagggacagg      840

caccaactgg gtaacctctg ctgaccccca ctctacttta ccataagtag ctccaaatcc      900

ttctagaaaa tctgaaaggc atagccccat atatcagtga tataaataga acctgcagca      960

ggctctggta aatgatgact acaaggtgga ctgggaggca gcccggcctt ggcaggcatc     1020

atcctctaaa tataaagatg agtttgttca gcctttgcag aaggaggatc cgtcgacggc     1080

gcgccacgcg tcagtttact caccagggat tcagaggcag cactgctgaa ccctgagccc     1140

ttggcacatc aggttggctg tcagaagtcg gcctttgtac atacacagtt cccttgtgag     1200

gcccagctgc gtgtcctagg agcggggcct ctctccacag cagagctcag cctctcaagt     1260

gtatggacag cacgggtgcc tgatgggtgg atttagccat gagttgaagg tggcttgggg     1320

agaatgagag ttctagagat agggagaagg ggttgccaat aggagagtgg aattcctgag     1380

cacctcgtca caggcagccg acagaacatg agccgcaggg cccaggctat ttatacctcg     1440

cctgtcacta tcagggtccc cacagctccc cccacctcca gccacacaca gcaggtcctt     1500

ttgctctttc tggtcccttc tctactcctc cccctcccta cctaaggtac ccaacgcgtt     1560

acgtggccac cgccttcggc accatcctca cgacacccaa atatggcgac gggtgaggaa     1620

tggtggggag ttatttttag agcggtgagg aaggtgggca ggcagcaggt gttggcgctc     1680

taaaaataac tcccgggagt tatttttaga gcggaggaat ggtggacacc caaatatggc     1740

gacggttcct cacccgtcgc catatttggg tgtccgccct cggccggggc cgcattcctg     1800

ggggccgggc ggtgctcccg cccgcctcga taaaaggctc cggggccggc ggcggcccac     1860

gagctacccg gaggagcggg aggcgccaag ctctagatct agaaagaggt aagggtttaa     1920

gggatggttg gttggtgggg tattaatgtt taattacctg gagcacctgc ctgaaatcac     1980

tttttttcag gttggaagct tgccaccatg gcggcagcgg cggcggcggc tgcagaacag     2040

caaagttcca atggtcctgt aaagaagtcc atgcgtgaga aggctgttga gagaaggagt     2100

gtcaataaag agcacaacag taactttaaa gctggataca ttccgattga tgaagatcgt     2160

ctccacaaaa cagggttgag aggaagaaag ggcaatttag ccatctgtgt gattatcctc     2220

ttgtttatcc tggctgtcat caatttaata ataacacttg ttatttgggc cgtgattcgc     2280

attggaccaa atggctgtga tagtatggag tttcatgaaa gtggcctgct tcgatttaag     2340

caagtatctg acatgggagt gatccaccct ctttataaaa gcacagtagg aggaaggcga     2400

aatgaaaatt tggtcatcac tggcaacaac cagcctattg tttttcagca agggacaaca     2460

aagctcagtg tagaaaacaa caaaacttct attacaagtg acatcggcat gcagtttttt     2520

gacccgagga ctcaaaatat cttattcagc acagactatg aaactcatga gtttcatttg     2580

ccaagtggag tgaaaagttt gaatgttcaa aaggcatcta ctgaaaggat taccagcaat     2640

gctaccagtg atttaaatat aaaagttgat gggcgtgcta ttgtgcgtgg aaatgaaggt     2700

gtattcatta tgggcaaaac cattgaattt cacatgggtg gtaatatgga gttaaaggcg     2760

gaaaacagta tcatcctaaa tggatctgtg atggtcagca ccacccgcct acccagttcc     2820

tccagtggag accagttggg tagtggtgac tgggtacgct acaagctctg catgtgtgct     2880

gatgggacgc tcttcaaggt gcaagtaacc agccagaaca tgggctgcca aatctcagac     2940

aacccctgtg gaaacactca ttaattcgaa acgtctagtc catcttgagc atctgacttc     3000

tggctaaata aaagatcttt attttcatta gatctgtgtg ttggtttttt gtgtgcgtcg     3060

agatccacgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     3120

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     3180

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     3240

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     3300

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     3360

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     3420

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     3480

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     3540

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     3600

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     3660

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     3720

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     3780

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     3840

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     3900

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     3960

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     4020

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     4080

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     4140

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     4200

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     4260

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     4320

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     4380

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     4440

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     4500

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     4560

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     4620

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     4680

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     4740

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     4800

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     4860

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     4920

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     4980

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     5040

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     5100

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     5160

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     5220

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     5280

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     5340

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     5400

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     5460

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     5520

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     5580

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     5640

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     5700

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     5760

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             5812


<210>  32
<211>  5755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE06-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  32
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatccgg gccaggggac ggtggcttct acgtgcttgg gacgttccca gccaccgtcc      660

catgttcccg gcggggggcc agctgtcccc accgccagcc caactcagca cttggtcagg      720

gtatcagctt ggtggggggg cgtgagccca gcccctgggg cggctcagcc catacaaggc      780

catggggctg ggcgcaaagc atgcctgggt tcagggtggg tatggtgcgg gagcagggag      840

gtgagaggct cagctgccct ccagaactcc tccctgggga caacccctcc cagccaatag      900

cacagcctag gtccccctat ataaggccac ggctgctggc ccttcctttg ggtcagtgtc      960

acctccagga tacagacagc cccccttcag cccagcccag ccaggtacgg atccgtcgac     1020

ggcgcgccac gcgtcagttt actcaccagg gattcagagg cagcactgct gaaccctgag     1080

cccttggcac atcaggttgg ctgtcagaag tcggcctttg tacatacaca gttcccttgt     1140

gaggcccagc tgcgtgtcct aggagcgggg cctctctcca cagcagagct cagcctctca     1200

agtgtatgga cagcacgggt gcctgatggg tggatttagc catgagttga aggtggcttg     1260

gggagaatga gagttctaga gatagggaga aggggttgcc aataggagag tggaattcct     1320

gagcacctcg tcacaggcag ccgacagaac atgagccgca gggcccaggc tatttatacc     1380

tcgcctgtca ctatcagggt ccccacagct ccccccacct ccagccacac acagcaggtc     1440

cttttgctct ttctggtccc ttctctactc ctccccctcc ctacctaagg tacccaacgc     1500

gttacgtggc caccgccttc ggcaccatcc tcacgacacc caaatatggc gacgggtgag     1560

gaatggtggg gagttatttt tagagcggtg aggaaggtgg gcaggcagca ggtgttggcg     1620

ctctaaaaat aactcccggg agttattttt agagcggagg aatggtggac acccaaatat     1680

ggcgacggtt cctcacccgt cgccatattt gggtgtccgc cctcggccgg ggccgcattc     1740

ctgggggccg ggcggtgctc ccgcccgcct cgataaaagg ctccggggcc ggcggcggcc     1800

cacgagctac ccggaggagc gggaggcgcc aagctctaga tctagaaaga ggtaagggtt     1860

taagggatgg ttggttggtg gggtattaat gtttaattac ctggagcacc tgcctgaaat     1920

cacttttttt caggttggaa gcttgccacc atggctgctg ccgctgctgc tgcagctgaa     1980

cagcaatcta gcaacggccc cgtgaagaaa tccatgcgcg agaaggccgt cgagcggaga     2040

tctgtgaaca aagagcacaa cagcaacttc aaggccggct acatccccat cgacgaggac     2100

agactgcaca agacaggcct gagaggcaga aagggcaatc tggccatctg cgtgatcatc     2160

ctgctgttca tcctggccgt gatcaacctg atcatcaccc tggtcatctg ggccgtgatt     2220

agaatcggcc ccaacggctg cgacagcatg gaatttcacg agagcggcct gctgcggttc     2280

aaacaggtgt ccgatatggg cgtgatccat ccactgtaca agagcaccgt tggcggcaga     2340

agaaacgaga atctggtcat caccggcaac aaccagccta tcgtgtttca gcagggcacc     2400

accaagctga gcgtggaaaa caacaagacc agcatcacca gcgacatcgg catgcagttc     2460

ttcgacccca gaacacagaa catcctgttc agcaccgact acgagacaca cgagttccat     2520

ctgcctagcg gcgtgaagtc cctgaatgtg cagaaggcca gcaccgagag aatcaccagc     2580

aatgccacct ccgacctgaa catcaaagtg gacggcagag ccatcgtgcg gggaaatgag     2640

ggcgtgttca tcatgggcaa gaccatcgag ttccacatgg gcggcaacat ggaactgaag     2700

gccgagaaca gcatcatcct gaacggcagc gtgatggtgt ccaccacaag actgccaagc     2760

agcagctctg gcgatcagct tggatctggc gactgggtcc gatacaagct gtgtatgtgt     2820

gccgacggca ccctgttcaa ggtgcaagtg acaagccaga acatgggctg ccagatcagc     2880

gacaaccctt gcggcaatac ccactgattc gaaacgtcaa gtccatcttg agcatctgac     2940

ttctggctaa ataaaagatc tttattttca ttagatctgt gtgttggttt tttgtgtgcg     3000

tcgagatcca cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3060

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     3120

ggcctcagtg agcgagcgag cgcgcagctg cctgcagggg cgcctgatgc ggtattttct     3180

ccttacgcat ctgtgcggta tttcacaccg catacgtcaa agcaaccata gtacgcgccc     3240

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     3300

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     3360

ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta     3420

cggcacctcg accccaaaaa acttgatttg ggtgatggtt cacgtagtgg gccatcgccc     3480

tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg     3540

ttccaaactg gaacaacact caaccctatc tcgggctatt cttttgattt ataagggatt     3600

ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat     3660

tttaacaaaa tattaacgtt tacaatttta tggtgcactc tcagtacaat ctgctctgat     3720

gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     3780

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     3840

cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta     3900

tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg     3960

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     4020

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     4080

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     4140

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     4200

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     4260

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     4320

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     4380

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     4440

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     4500

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     4560

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     4620

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     4680

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     4740

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     4800

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     4860

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     4920

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4980

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     5040

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     5100

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     5160

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     5220

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     5280

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     5340

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     5400

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     5460

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     5520

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     5580

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     5640

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     5700

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgt          5755


<210>  33
<211>  5755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE06-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  33
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatccgg gccaggggac ggtggcttct acgtgcttgg gacgttccca gccaccgtcc      660

catgttcccg gcggggggcc agctgtcccc accgccagcc caactcagca cttggtcagg      720

gtatcagctt ggtggggggg cgtgagccca gcccctgggg cggctcagcc catacaaggc      780

catggggctg ggcgcaaagc atgcctgggt tcagggtggg tatggtgcgg gagcagggag      840

gtgagaggct cagctgccct ccagaactcc tccctgggga caacccctcc cagccaatag      900

cacagcctag gtccccctat ataaggccac ggctgctggc ccttcctttg ggtcagtgtc      960

acctccagga tacagacagc cccccttcag cccagcccag ccaggtacgg atccgtcgac     1020

ggcgcgccac gcgtcagttt actcaccagg gattcagagg cagcactgct gaaccctgag     1080

cccttggcac atcaggttgg ctgtcagaag tcggcctttg tacatacaca gttcccttgt     1140

gaggcccagc tgcgtgtcct aggagcgggg cctctctcca cagcagagct cagcctctca     1200

agtgtatgga cagcacgggt gcctgatggg tggatttagc catgagttga aggtggcttg     1260

gggagaatga gagttctaga gatagggaga aggggttgcc aataggagag tggaattcct     1320

gagcacctcg tcacaggcag ccgacagaac atgagccgca gggcccaggc tatttatacc     1380

tcgcctgtca ctatcagggt ccccacagct ccccccacct ccagccacac acagcaggtc     1440

cttttgctct ttctggtccc ttctctactc ctccccctcc ctacctaagg tacccaacgc     1500

gttacgtggc caccgccttc ggcaccatcc tcacgacacc caaatatggc gacgggtgag     1560

gaatggtggg gagttatttt tagagcggtg aggaaggtgg gcaggcagca ggtgttggcg     1620

ctctaaaaat aactcccggg agttattttt agagcggagg aatggtggac acccaaatat     1680

ggcgacggtt cctcacccgt cgccatattt gggtgtccgc cctcggccgg ggccgcattc     1740

ctgggggccg ggcggtgctc ccgcccgcct cgataaaagg ctccggggcc ggcggcggcc     1800

cacgagctac ccggaggagc gggaggcgcc aagctctaga tctagaaaga ggtaagggtt     1860

taagggatgg ttggttggtg gggtattaat gtttaattac ctggagcacc tgcctgaaat     1920

cacttttttt caggttggaa gcttgccacc atggcggcag cggcggcggc ggctgcagaa     1980

cagcaaagtt ccaatggtcc tgtaaagaag tccatgcgtg agaaggctgt tgagagaagg     2040

agtgtcaata aagagcacaa cagtaacttt aaagctggat acattccgat tgatgaagat     2100

cgtctccaca aaacagggtt gagaggaaga aagggcaatt tagccatctg tgtgattatc     2160

ctcttgttta tcctggctgt catcaattta ataataacac ttgttatttg ggccgtgatt     2220

cgcattggac caaatggctg tgatagtatg gagtttcatg aaagtggcct gcttcgattt     2280

aagcaagtat ctgacatggg agtgatccac cctctttata aaagcacagt aggaggaagg     2340

cgaaatgaaa atttggtcat cactggcaac aaccagccta ttgtttttca gcaagggaca     2400

acaaagctca gtgtagaaaa caacaaaact tctattacaa gtgacatcgg catgcagttt     2460

tttgacccga ggactcaaaa tatcttattc agcacagact atgaaactca tgagtttcat     2520

ttgccaagtg gagtgaaaag tttgaatgtt caaaaggcat ctactgaaag gattaccagc     2580

aatgctacca gtgatttaaa tataaaagtt gatgggcgtg ctattgtgcg tggaaatgaa     2640

ggtgtattca ttatgggcaa aaccattgaa tttcacatgg gtggtaatat ggagttaaag     2700

gcggaaaaca gtatcatcct aaatggatct gtgatggtca gcaccacccg cctacccagt     2760

tcctccagtg gagaccagtt gggtagtggt gactgggtac gctacaagct ctgcatgtgt     2820

gctgatggga cgctcttcaa ggtgcaagta accagccaga acatgggctg ccaaatctca     2880

gacaacccct gtggaaacac tcattaattc gaaacgtcaa gtccatcttg agcatctgac     2940

ttctggctaa ataaaagatc tttattttca ttagatctgt gtgttggttt tttgtgtgcg     3000

tcgagatcca cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc     3060

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     3120

ggcctcagtg agcgagcgag cgcgcagctg cctgcagggg cgcctgatgc ggtattttct     3180

ccttacgcat ctgtgcggta tttcacaccg catacgtcaa agcaaccata gtacgcgccc     3240

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     3300

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     3360

ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta     3420

cggcacctcg accccaaaaa acttgatttg ggtgatggtt cacgtagtgg gccatcgccc     3480

tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg     3540

ttccaaactg gaacaacact caaccctatc tcgggctatt cttttgattt ataagggatt     3600

ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat     3660

tttaacaaaa tattaacgtt tacaatttta tggtgcactc tcagtacaat ctgctctgat     3720

gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     3780

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     3840

cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta     3900

tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg     3960

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     4020

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     4080

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     4140

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     4200

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     4260

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     4320

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     4380

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     4440

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     4500

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     4560

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     4620

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     4680

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     4740

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     4800

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     4860

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     4920

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4980

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     5040

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     5100

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     5160

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     5220

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     5280

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     5340

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     5400

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     5460

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     5520

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     5580

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     5640

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     5700

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgt          5755


<210>  34
<211>  6296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-h-SGco-pA

<400>  34
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgcccgta      600

cggtcgacgg atcccctttt agagaatcca cacctgtccc agttgctggg ttccactacc      660

aaaagtgaat tgcaactatt ttaggagcac ttaagcacat ccgaaaaatg agtgattctg      720

ttctggccca caccacatca ctgatgtacc cccttaaagc atgtccctga gttcatcaca      780

gaagactgct cctcctgtgc cctccacaag gttagaactg tccttgtctt agggaaaaag      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gggacaggca      900

ccaactgggt aacctctgct gacccccact ctactttacc ataagtagct ccaaatcctt      960

ctagaaaatc tgaaaggcat agccccatat atcagtgata taaatagaac ctgcagcagg     1020

ctctggtaaa tgatgactac aaggtggact gggaggcagc ccggccttgg caggcatcat     1080

cctctaaata taaagatgag tttgttcagc ctttgcagaa ggaggcgcgc cgtcgacgga     1140

tccgggccag gggacggtgg cttctacgtg cttgggacgt tcccagccac cgtcccatgt     1200

tcccggcggg gggccagctg tccccaccgc cagcccaact cagcacttgg tcagggtatc     1260

agcttggtgg gggggcgtga gcccagcccc tggggcggct cagcccatac aaggccatgg     1320

ggctgggcgc aaagcatgcc tgggttcagg gtgggtatgg tgcgggagca gggaggtgag     1380

aggctcagct gccctccaga actcctccct ggggacaacc cctcccagcc aatagcacag     1440

cctaggtccc cctatataag gccacggctg ctggcccttc ctttgggtca gtgtcacctc     1500

caggatacag acagcccccc ttcagcccag cccagccagg tacggatccg tcgaccgtac     1560

gggcgcgcca cgcgtcagtt tactcaccag ggattcagag gcagcactgc tgaaccctga     1620

gcccttggca catcaggttg gctgtcagaa gtcggccttt gtacatacac agttcccttg     1680

tgaggcccag ctgcgtgtcc taggagcggg gcctctctcc acagcagagc tcagcctctc     1740

aagtgtatgg acagcacggg tgcctgatgg gtggatttag ccatgagttg aaggtggctt     1800

ggggagaatg agagttctag agatagggag aaggggttgc caataggaga gtggaattcc     1860

tgagcacctc gtcacaggca gccgacagaa catgagccgc agggcccagg ctatttatac     1920

ctcgcctgtc actatcaggg tccccacagc tccccccacc tccagccaca cacagcaggt     1980

ccttttgctc tttctggtcc cttctctact cctccccctc cctacctaag gtacccaacg     2040

cgttacgtgg ccaccgcctt cggcaccatc ctcacgacac ccaaatatgg cgacgggtga     2100

ggaatggtgg ggagttattt ttagagcggt gaggaaggtg ggcaggcagc aggtgttggc     2160

gctctaaaaa taactcccgg gagttatttt tagagcggag gaatggtgga cacccaaata     2220

tggcgacggt tcctcacccg tcgccatatt tgggtgtccg ccctcggccg gggccgcatt     2280

cctgggggcc gggcggtgct cccgcccgcc tcgataaaag gctccggggc cggcggcggc     2340

ccacgagcta cccggaggag cgggaggcgc caagctctag atctagaaag aggtaagggt     2400

ttaagggatg gttggttggt ggggtattaa tgtttaatta cctggagcac ctgcctgaaa     2460

tcactttttt tcaggttgga agcttgccac catggctgct gccgctgctg ctgcagctga     2520

acagcaatct agcaacggcc ccgtgaagaa atccatgcgc gagaaggccg tcgagcggag     2580

atctgtgaac aaagagcaca acagcaactt caaggccggc tacatcccca tcgacgagga     2640

cagactgcac aagacaggcc tgagaggcag aaagggcaat ctggccatct gcgtgatcat     2700

cctgctgttc atcctggccg tgatcaacct gatcatcacc ctggtcatct gggccgtgat     2760

tagaatcggc cccaacggct gcgacagcat ggaatttcac gagagcggcc tgctgcggtt     2820

caaacaggtg tccgatatgg gcgtgatcca tccactgtac aagagcaccg ttggcggcag     2880

aagaaacgag aatctggtca tcaccggcaa caaccagcct atcgtgtttc agcagggcac     2940

caccaagctg agcgtggaaa acaacaagac cagcatcacc agcgacatcg gcatgcagtt     3000

cttcgacccc agaacacaga acatcctgtt cagcaccgac tacgagacac acgagttcca     3060

tctgcctagc ggcgtgaagt ccctgaatgt gcagaaggcc agcaccgaga gaatcaccag     3120

caatgccacc tccgacctga acatcaaagt ggacggcaga gccatcgtgc ggggaaatga     3180

gggcgtgttc atcatgggca agaccatcga gttccacatg ggcggcaaca tggaactgaa     3240

ggccgagaac agcatcatcc tgaacggcag cgtgatggtg tccaccacaa gactgccaag     3300

cagcagctct ggcgatcagc ttggatctgg cgactgggtc cgatacaagc tgtgtatgtg     3360

tgccgacggc accctgttca aggtgcaagt gacaagccag aacatgggct gccagatcag     3420

cgacaaccct tgcggcaata cccactgatt cgaaacgtca agtccatctt gagcatctga     3480

cttctggcta aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtgc     3540

gtcgagatcc acggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3600

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3660

cggcctcagt gagcgagcga gcgcgcagct gcctgcaggg gcgcctgatg cggtattttc     3720

tccttacgca tctgtgcggt atttcacacc gcatacgtca aagcaaccat agtacgcgcc     3780

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     3840

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     3900

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     3960

acggcacctc gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc     4020

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     4080

gttccaaact ggaacaacac tcaaccctat ctcgggctat tcttttgatt tataagggat     4140

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     4200

ttttaacaaa atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga     4260

tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc     4320

ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg     4380

tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct     4440

atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg     4500

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc     4560

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag     4620

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt     4680

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt     4740

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga     4800

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat     4860

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga     4920

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag     4980

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg     5040

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg     5100

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt     5160

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg     5220

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc     5280

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg     5340

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac     5400

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact     5460

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa     5520

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa     5580

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg     5640

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc     5700

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac     5760

tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca     5820

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt     5880

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc     5940

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg     6000

aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc     6060

cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac     6120

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct     6180

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc     6240

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgt         6296


<210>  35
<211>  6296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-h-SG-pA

<400>  35
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgcccgta      600

cggtcgacgg atcccctttt agagaatcca cacctgtccc agttgctggg ttccactacc      660

aaaagtgaat tgcaactatt ttaggagcac ttaagcacat ccgaaaaatg agtgattctg      720

ttctggccca caccacatca ctgatgtacc cccttaaagc atgtccctga gttcatcaca      780

gaagactgct cctcctgtgc cctccacaag gttagaactg tccttgtctt agggaaaaag      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gggacaggca      900

ccaactgggt aacctctgct gacccccact ctactttacc ataagtagct ccaaatcctt      960

ctagaaaatc tgaaaggcat agccccatat atcagtgata taaatagaac ctgcagcagg     1020

ctctggtaaa tgatgactac aaggtggact gggaggcagc ccggccttgg caggcatcat     1080

cctctaaata taaagatgag tttgttcagc ctttgcagaa ggaggcgcgc cgtcgacgga     1140

tccgggccag gggacggtgg cttctacgtg cttgggacgt tcccagccac cgtcccatgt     1200

tcccggcggg gggccagctg tccccaccgc cagcccaact cagcacttgg tcagggtatc     1260

agcttggtgg gggggcgtga gcccagcccc tggggcggct cagcccatac aaggccatgg     1320

ggctgggcgc aaagcatgcc tgggttcagg gtgggtatgg tgcgggagca gggaggtgag     1380

aggctcagct gccctccaga actcctccct ggggacaacc cctcccagcc aatagcacag     1440

cctaggtccc cctatataag gccacggctg ctggcccttc ctttgggtca gtgtcacctc     1500

caggatacag acagcccccc ttcagcccag cccagccagg tacggatccg tcgaccgtac     1560

gggcgcgcca cgcgtcagtt tactcaccag ggattcagag gcagcactgc tgaaccctga     1620

gcccttggca catcaggttg gctgtcagaa gtcggccttt gtacatacac agttcccttg     1680

tgaggcccag ctgcgtgtcc taggagcggg gcctctctcc acagcagagc tcagcctctc     1740

aagtgtatgg acagcacggg tgcctgatgg gtggatttag ccatgagttg aaggtggctt     1800

ggggagaatg agagttctag agatagggag aaggggttgc caataggaga gtggaattcc     1860

tgagcacctc gtcacaggca gccgacagaa catgagccgc agggcccagg ctatttatac     1920

ctcgcctgtc actatcaggg tccccacagc tccccccacc tccagccaca cacagcaggt     1980

ccttttgctc tttctggtcc cttctctact cctccccctc cctacctaag gtacccaacg     2040

cgttacgtgg ccaccgcctt cggcaccatc ctcacgacac ccaaatatgg cgacgggtga     2100

ggaatggtgg ggagttattt ttagagcggt gaggaaggtg ggcaggcagc aggtgttggc     2160

gctctaaaaa taactcccgg gagttatttt tagagcggag gaatggtgga cacccaaata     2220

tggcgacggt tcctcacccg tcgccatatt tgggtgtccg ccctcggccg gggccgcatt     2280

cctgggggcc gggcggtgct cccgcccgcc tcgataaaag gctccggggc cggcggcggc     2340

ccacgagcta cccggaggag cgggaggcgc caagctctag atctagaaag aggtaagggt     2400

ttaagggatg gttggttggt ggggtattaa tgtttaatta cctggagcac ctgcctgaaa     2460

tcactttttt tcaggttgga agcttgccac catggcggca gcggcggcgg cggctgcaga     2520

acagcaaagt tccaatggtc ctgtaaagaa gtccatgcgt gagaaggctg ttgagagaag     2580

gagtgtcaat aaagagcaca acagtaactt taaagctgga tacattccga ttgatgaaga     2640

tcgtctccac aaaacagggt tgagaggaag aaagggcaat ttagccatct gtgtgattat     2700

cctcttgttt atcctggctg tcatcaattt aataataaca cttgttattt gggccgtgat     2760

tcgcattgga ccaaatggct gtgatagtat ggagtttcat gaaagtggcc tgcttcgatt     2820

taagcaagta tctgacatgg gagtgatcca ccctctttat aaaagcacag taggaggaag     2880

gcgaaatgaa aatttggtca tcactggcaa caaccagcct attgtttttc agcaagggac     2940

aacaaagctc agtgtagaaa acaacaaaac ttctattaca agtgacatcg gcatgcagtt     3000

ttttgacccg aggactcaaa atatcttatt cagcacagac tatgaaactc atgagtttca     3060

tttgccaagt ggagtgaaaa gtttgaatgt tcaaaaggca tctactgaaa ggattaccag     3120

caatgctacc agtgatttaa atataaaagt tgatgggcgt gctattgtgc gtggaaatga     3180

aggtgtattc attatgggca aaaccattga atttcacatg ggtggtaata tggagttaaa     3240

ggcggaaaac agtatcatcc taaatggatc tgtgatggtc agcaccaccc gcctacccag     3300

ttcctccagt ggagaccagt tgggtagtgg tgactgggta cgctacaagc tctgcatgtg     3360

tgctgatggg acgctcttca aggtgcaagt aaccagccag aacatgggct gccaaatctc     3420

agacaacccc tgtggaaaca ctcattaatt cgaaacgtca agtccatctt gagcatctga     3480

cttctggcta aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtgc     3540

gtcgagatcc acggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     3600

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     3660

cggcctcagt gagcgagcga gcgcgcagct gcctgcaggg gcgcctgatg cggtattttc     3720

tccttacgca tctgtgcggt atttcacacc gcatacgtca aagcaaccat agtacgcgcc     3780

ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact     3840

tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc     3900

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt     3960

acggcacctc gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc     4020

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt     4080

gttccaaact ggaacaacac tcaaccctat ctcgggctat tcttttgatt tataagggat     4140

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa     4200

ttttaacaaa atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga     4260

tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc     4320

ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg     4380

tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct     4440

atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg     4500

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc     4560

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag     4620

tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt     4680

tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt     4740

gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga     4800

acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat     4860

tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga     4920

gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag     4980

tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg     5040

accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg     5100

ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt     5160

agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg     5220

gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc     5280

ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg     5340

tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac     5400

ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact     5460

gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa     5520

acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa     5580

aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg     5640

atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc     5700

gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac     5760

tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca     5820

ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt     5880

ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc     5940

ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg     6000

aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc     6060

cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac     6120

gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct     6180

ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc     6240

cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgt         6296


<210>  36
<211>  5961
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE06-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  36
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgggc caggggacgg tggcttctac gtgcttggga cgttcccagc      180

caccgtccca tgttcccggc ggggggccag ctgtccccac cgccagccca actcagcact      240

tggtcagggt atcagcttgg tgggggggcg tgagcccagc ccctggggcg gctcagccca      300

tacaaggcca tggggctggg cgcaaagcat gcctgggttc agggtgggta tggtgcggga      360

gcagggaggt gagaggctca gctgccctcc agaactcctc cctggggaca acccctccca      420

gccaatagca cagcctaggt ccccctatat aaggccacgg ctgctggccc ttcctttggg      480

tcagtgtcac ctccaggata cagacagccc cccttcagcc cagcccagcc aggtacggcg      540

cgccacgcgt cagtttactc accagggatt cagaggcagc actgctgaac cctgagccct      600

tggcacatca ggttggctgt cagaagtcgg cctttgtaca tacacagttc ccttgtgagg      660

cccagctgcg tgtcctagga gcggggcctc tctccacagc agagctcagc ctctcaagtg      720

tatggacagc acgggtgcct gatgggtgga tttagccatg agttgaaggt ggcttgggga      780

gaatgagagt tctagagata gggagaaggg gttgccaata ggagagtgga attcctgagc      840

acctcgtcac aggcagccga cagaacatga gccgcagggc ccaggctatt tatacctcgc      900

ctgtcactat cagggtcccc acagctcccc ccacctccag ccacacacag caggtccttt      960

tgctctttct ggtcccttct ctactcctcc ccctccctac ctaaggtacc caacgcgtta     1020

cgtggccacc gccttcggca ccatcctcac gacacccaaa tatggcgacg ggtgaggaat     1080

ggtggggagt tatttttaga gcggtgagga aggtgggcag gcagcaggtg ttggcgctct     1140

aaaaataact cccgggagtt atttttagag cggaggaatg gtggacaccc aaatatggcg     1200

acggttcctc acccgtcgcc atatttgggt gtccgccctc ggccggggcc gcattcctgg     1260

gggccgggcg gtgctcccgc ccgcctcgat aaaaggctcc ggggccggcg gcggcccacg     1320

agctacccgg aggagcggga ggcgccaagc tctagatcta gaaagaggta agggtttaag     1380

ggatggttgg ttggtggggt attaatgttt aattacctgg agcacctgcc tgaaatcact     1440

ttttttcagg ttggaagctt atggaagatg ccaaaaacat taagaagggc ccagcgccat     1500

tctacccact cgaggacggg accgccggcg agcagctgca caaagccatg aagcgctacg     1560

ccctggtgcc cggcaccatc gcctttaccg acgcacatat cgaggtggac attacctacg     1620

ccgagtactt cgagatgagc gttcggctgg cagaagctat gaagcgctat gggctgaata     1680

caaaccatcg gatcgtggtg tgcagcgaga atagcttgca gttcttcatg cccgtgttgg     1740

gtgccctgtt catcggtgtg gctgtggccc cagctaacga catctacaac gagcgcgagc     1800

tgctgaacag catgggcatc agccagccca ccgtcgtatt cgtgagcaag aaagggctgc     1860

aaaagatcct caacgtgcaa aagaagctac cgatcataca aaagatcatc atcatggata     1920

gcaagaccga ctaccagggc ttccaaagca tgtacacctt cgtgacttcc catttgccac     1980

ccggcttcaa cgagtacgac ttcgtgcccg agagcttcga ccgggacaaa accatcgccc     2040

tgatcatgaa cagtagtggc agtaccggat tgcccaaggg cgtagcccta ccgcaccgca     2100

ccgcttgtgt ccgattcagt catgcccgcg accccatctt cggcaaccag atcatccccg     2160

acaccgctat cctcagcgtg gtgccatttc accacggctt cggcatgttc accacgctgg     2220

gctacttgat ctgcggcttt cgggtcgtgc tcatgtaccg cttcgaggag gagctattct     2280

tgcgcagctt gcaagactat aagattcaat ctgccctgct ggtgcccaca ctatttagct     2340

tcttcgctaa gagcactctc atcgacaagt acgacctaag caacttgcac gagatcgcca     2400

gcggcggggc gccgctcagc aaggaggtag gtgaggccgt ggccaaacgc ttccacctac     2460

caggcatccg ccagggctac ggcctgacag aaacaaccag cgccattctg atcacccccg     2520

aaggggacga caagcctggc gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg     2580

tggacttgga caccggtaag acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg     2640

gccccatgat catgagcggc tacgttaaca accccgaggc tacaaacgct ctcatcgaca     2700

aggacggctg gctgcacagc ggcgacatcg cctactggga cgaggacgag cacttcttca     2760

tcgtggaccg gctgaagagc ctgatcaaat acaagggcta ccaggtagcc ccagccgaac     2820

tggagagcat cctgctgcaa caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg     2880

acgacgatgc cggcgagctg cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga     2940

ccgagaagga gatcgtggac tatgtggcca gccaggttac aaccgccaag aagctgcgcg     3000

gtggtgttgt gttcgtggac gaggtgccta aaggactgac cggcaagttg gacgcccgca     3060

agatccgcga gattctcatt aaggccaaga agggcggcaa gatcgccgtg taattcgaaa     3120

cgtctagtcc atcttgagca tctgacttct ggctaaataa aagatcttta ttttcattag     3180

atctgtgtgt tggttttttg tgtgcgtcga gatccacggc cgcaggaacc cctagtgatg     3240

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc     3300

gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg     3360

caggggcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata     3420

cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     3480

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     3540

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     3600

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gatttgggtg     3660

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     3720

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     3780

gctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     3840

tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca attttatggt     3900

gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa     3960

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     4020

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     4080

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     4140

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt     4200

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat     4260

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt     4320

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg     4380

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga     4440

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc     4500

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac     4560

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg     4620

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca     4680

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg     4740

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg     4800

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg     4860

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag     4920

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg     4980

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct     5040

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     5100

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     5160

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     5220

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     5280

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     5340

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     5400

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     5460

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     5520

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     5580

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     5640

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     5700

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     5760

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     5820

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     5880

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     5940

gctggccttt tgctcacatg t                                               5961


<210>  37
<211>  6081
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE04-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  37
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gcccctttta gagaatccac acctgtccca      180

gttgctgggt tccactacca aaagtgaatt gcaactattt taggagcact taagcacatc      240

cgaaaaatga gtgattctgt tctggcccac accacatcac tgatgtaccc ccttaaagca      300

tgtccctgag ttcatcacag aagactgctc ctcctgtgcc ctccacaagg ttagaactgt      360

ccttgtctta gggaaaaagg agagagagag agagagagag agagagagag agagagagag      420

agagagagag ggacaggcac caactgggta acctctgctg acccccactc tactttacca      480

taagtagctc caaatccttc tagaaaatct gaaaggcata gccccatata tcagtgatat      540

aaatagaacc tgcagcaggc tctggtaaat gatgactaca aggtggactg ggaggcagcc      600

cggccttggc aggcatcatc ctctaaatat aaagatgagt ttgttcagcc tttgcagaag      660

gaggcgcgcc acgcgtcagt ttactcacca gggattcaga ggcagcactg ctgaaccctg      720

agcccttggc acatcaggtt ggctgtcaga agtcggcctt tgtacataca cagttccctt      780

gtgaggccca gctgcgtgtc ctaggagcgg ggcctctctc cacagcagag ctcagcctct      840

caagtgtatg gacagcacgg gtgcctgatg ggtggattta gccatgagtt gaaggtggct      900

tggggagaat gagagttcta gagataggga gaaggggttg ccaataggag agtggaattc      960

ctgagcacct cgtcacaggc agccgacaga acatgagccg cagggcccag gctatttata     1020

cctcgcctgt cactatcagg gtccccacag ctccccccac ctccagccac acacagcagg     1080

tccttttgct ctttctggtc ccttctctac tcctccccct ccctacctaa ggtacccaac     1140

gcgttacgtg gccaccgcct tcggcaccat cctcacgaca cccaaatatg gcgacgggtg     1200

aggaatggtg gggagttatt tttagagcgg tgaggaaggt gggcaggcag caggtgttgg     1260

cgctctaaaa ataactcccg ggagttattt ttagagcgga ggaatggtgg acacccaaat     1320

atggcgacgg ttcctcaccc gtcgccatat ttgggtgtcc gccctcggcc ggggccgcat     1380

tcctgggggc cgggcggtgc tcccgcccgc ctcgataaaa ggctccgggg ccggcggcgg     1440

cccacgagct acccggagga gcgggaggcg ccaagctcta gatctagaaa gaggtaaggg     1500

tttaagggat ggttggttgg tggggtatta atgtttaatt acctggagca cctgcctgaa     1560

atcacttttt ttcaggttgg aagcttatgg aagatgccaa aaacattaag aagggcccag     1620

cgccattcta cccactcgag gacgggaccg ccggcgagca gctgcacaaa gccatgaagc     1680

gctacgccct ggtgcccggc accatcgcct ttaccgacgc acatatcgag gtggacatta     1740

cctacgccga gtacttcgag atgagcgttc ggctggcaga agctatgaag cgctatgggc     1800

tgaatacaaa ccatcggatc gtggtgtgca gcgagaatag cttgcagttc ttcatgcccg     1860

tgttgggtgc cctgttcatc ggtgtggctg tggccccagc taacgacatc tacaacgagc     1920

gcgagctgct gaacagcatg ggcatcagcc agcccaccgt cgtattcgtg agcaagaaag     1980

ggctgcaaaa gatcctcaac gtgcaaaaga agctaccgat catacaaaag atcatcatca     2040

tggatagcaa gaccgactac cagggcttcc aaagcatgta caccttcgtg acttcccatt     2100

tgccacccgg cttcaacgag tacgacttcg tgcccgagag cttcgaccgg gacaaaacca     2160

tcgccctgat catgaacagt agtggcagta ccggattgcc caagggcgta gccctaccgc     2220

accgcaccgc ttgtgtccga ttcagtcatg cccgcgaccc catcttcggc aaccagatca     2280

tccccgacac cgctatcctc agcgtggtgc catttcacca cggcttcggc atgttcacca     2340

cgctgggcta cttgatctgc ggctttcggg tcgtgctcat gtaccgcttc gaggaggagc     2400

tattcttgcg cagcttgcaa gactataaga ttcaatctgc cctgctggtg cccacactat     2460

ttagcttctt cgctaagagc actctcatcg acaagtacga cctaagcaac ttgcacgaga     2520

tcgccagcgg cggggcgccg ctcagcaagg aggtaggtga ggccgtggcc aaacgcttcc     2580

acctaccagg catccgccag ggctacggcc tgacagaaac aaccagcgcc attctgatca     2640

cccccgaagg ggacgacaag cctggcgcag taggcaaggt ggtgcccttc ttcgaggcta     2700

aggtggtgga cttggacacc ggtaagacac tgggtgtgaa ccagcgcggc gagctgtgcg     2760

tccgtggccc catgatcatg agcggctacg ttaacaaccc cgaggctaca aacgctctca     2820

tcgacaagga cggctggctg cacagcggcg acatcgccta ctgggacgag gacgagcact     2880

tcttcatcgt ggaccggctg aagagcctga tcaaatacaa gggctaccag gtagccccag     2940

ccgaactgga gagcatcctg ctgcaacacc ccaacatctt cgacgccggg gtcgccggcc     3000

tgcccgacga cgatgccggc gagctgcccg ccgcagtcgt cgtgctggaa cacggtaaaa     3060

ccatgaccga gaaggagatc gtggactatg tggccagcca ggttacaacc gccaagaagc     3120

tgcgcggtgg tgttgtgttc gtggacgagg tgcctaaagg actgaccggc aagttggacg     3180

cccgcaagat ccgcgagatt ctcattaagg ccaagaaggg cggcaagatc gccgtgtaat     3240

tcgaaacgtc acgtccatct tgagcatctg acttctggct aaataaaaga tctttatttt     3300

cattagatct gtgtgttggt tttttgtgtg cgtcgagatc cacggccgca ggaaccccta     3360

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     3420

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc     3480

tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     3540

cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg cgcattaagc gcggcgggtg     3600

tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg     3660

ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg     3720

ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt     3780

tgggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt     3840

tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta     3900

tctcgggcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa     3960

atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt     4020

tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc     4080

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac     4140

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac     4200

gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa     4260

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt     4320

tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc     4380

ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc     4440

ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa     4500

aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg     4560

gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag     4620

ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc     4680

gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta     4740

cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg     4800

cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca     4860

acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac     4920

caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat     4980

taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg     5040

ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata     5100

aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta     5160

agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa     5220

atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag     5280

tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg     5340

tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact     5400

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg     5460

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc     5520

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata     5580

ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta     5640

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc     5700

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg     5760

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac     5820

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     5880

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     5940

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     6000

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg     6060

ccttttgctg gccttttgct c                                               6081


<210>  38
<211>  6013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  38
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccacgc      600

gtcagtttac tcaccaggga ttcagaggca gcactgctga accctgagcc cttggcacat      660

caggttggct gtcagaagtc ggcctttgta catacacagt tcccttgtga ggcccagctg      720

cgtgtcctag gagcggggcc tctctccaca gcagagctca gcctctcaag tgtatggaca      780

gcacgggtgc ctgatgggtg gatttagcca tgagttgaag gtggcttggg gagaatgaga      840

gttctagaga tagggagaag gggttgccaa taggagagtg gaattcctga gcacctcgtc      900

acaggcagcc gacagaacat gagccgcagg gcccaggcta tttatacctc gcctgtcact      960

atcagggtcc ccacagctcc ccccacctcc agccacacac agcaggtcct tttgctcttt     1020

ctggtccctt ctctactcct ccccctccct acctaaggta cccaacgcgt tacgtggcca     1080

ccgccttcgg caccatcctc acgacaccca aatatggcga cgggtgagga atggtgggga     1140

gttattttta gagcggtgag gaaggtgggc aggcagcagg tgttggcgct ctaaaaataa     1200

ctcccgggag ttatttttag agcggaggaa tggtggacac ccaaatatgg cgacggttcc     1260

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg     1320

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc     1380

ggaggagcgg gaggcgccaa gctctagatc tagaaagagg taagggttta agggatggtt     1440

ggttggtggg gtattaatgt ttaattacct ggagcacctg cctgaaatca ctttttttca     1500

ggttggaagc ttatggaaga tgccaaaaac attaagaagg gcccagcgcc attctaccca     1560

ctcgaggacg ggaccgccgg cgagcagctg cacaaagcca tgaagcgcta cgccctggtg     1620

cccggcacca tcgcctttac cgacgcacat atcgaggtgg acattaccta cgccgagtac     1680

ttcgagatga gcgttcggct ggcagaagct atgaagcgct atgggctgaa tacaaaccat     1740

cggatcgtgg tgtgcagcga gaatagcttg cagttcttca tgcccgtgtt gggtgccctg     1800

ttcatcggtg tggctgtggc cccagctaac gacatctaca acgagcgcga gctgctgaac     1860

agcatgggca tcagccagcc caccgtcgta ttcgtgagca agaaagggct gcaaaagatc     1920

ctcaacgtgc aaaagaagct accgatcata caaaagatca tcatcatgga tagcaagacc     1980

gactaccagg gcttccaaag catgtacacc ttcgtgactt cccatttgcc acccggcttc     2040

aacgagtacg acttcgtgcc cgagagcttc gaccgggaca aaaccatcgc cctgatcatg     2100

aacagtagtg gcagtaccgg attgcccaag ggcgtagccc taccgcaccg caccgcttgt     2160

gtccgattca gtcatgcccg cgaccccatc ttcggcaacc agatcatccc cgacaccgct     2220

atcctcagcg tggtgccatt tcaccacggc ttcggcatgt tcaccacgct gggctacttg     2280

atctgcggct ttcgggtcgt gctcatgtac cgcttcgagg aggagctatt cttgcgcagc     2340

ttgcaagact ataagattca atctgccctg ctggtgccca cactatttag cttcttcgct     2400

aagagcactc tcatcgacaa gtacgaccta agcaacttgc acgagatcgc cagcggcggg     2460

gcgccgctca gcaaggaggt aggtgaggcc gtggccaaac gcttccacct accaggcatc     2520

cgccagggct acggcctgac agaaacaacc agcgccattc tgatcacccc cgaaggggac     2580

gacaagcctg gcgcagtagg caaggtggtg cccttcttcg aggctaaggt ggtggacttg     2640

gacaccggta agacactggg tgtgaaccag cgcggcgagc tgtgcgtccg tggccccatg     2700

atcatgagcg gctacgttaa caaccccgag gctacaaacg ctctcatcga caaggacggc     2760

tggctgcaca gcggcgacat cgcctactgg gacgaggacg agcacttctt catcgtggac     2820

cggctgaaga gcctgatcaa atacaagggc taccaggtag ccccagccga actggagagc     2880

atcctgctgc aacaccccaa catcttcgac gccggggtcg ccggcctgcc cgacgacgat     2940

gccggcgagc tgcccgccgc agtcgtcgtg ctggaacacg gtaaaaccat gaccgagaag     3000

gagatcgtgg actatgtggc cagccaggtt acaaccgcca agaagctgcg cggtggtgtt     3060

gtgttcgtgg acgaggtgcc taaaggactg accggcaagt tggacgcccg caagatccgc     3120

gagattctca ttaaggccaa gaagggcggc aagatcgccg tgtaattcga aacgtcaagt     3180

ccatcttgag catctgactt ctggctaaat aaaagatctt tattttcatt agatctgtgt     3240

gttggttttt tgtgtgcgtc gagatccacg gccgcaggaa cccctagtga tggagttggc     3300

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     3360

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcagctgcc tgcaggggcg     3420

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tacgtcaaag     3480

caaccatagt acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     3540

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     3600

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     3660

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgatttggg tgatggttca     3720

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     3780

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc gggctattct     3840

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     3900

caaaaattta acgcgaattt taacaaaata ttaacgttta caattttatg gtgcactctc     3960

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct     4020

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     4080

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag     4140

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     4200

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     4260

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     4320

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     4380

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     4440

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     4500

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     4560

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     4620

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     4680

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     4740

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     4800

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     4860

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     4920

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     4980

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     5040

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     5100

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     5160

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     5220

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     5280

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     5340

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     5400

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     5460

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     5520

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     5580

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     5640

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     5700

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     5760

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     5820

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     5880

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     5940

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     6000

tttgctcaca tgt                                                        6013


<210>  39
<211>  6502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE06-CRE04-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  39
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgggc caggggacgg tggcttctac gtgcttggga cgttcccagc      180

caccgtccca tgttcccggc ggggggccag ctgtccccac cgccagccca actcagcact      240

tggtcagggt atcagcttgg tgggggggcg tgagcccagc ccctggggcg gctcagccca      300

tacaaggcca tggggctggg cgcaaagcat gcctgggttc agggtgggta tggtgcggga      360

gcagggaggt gagaggctca gctgccctcc agaactcctc cctggggaca acccctccca      420

gccaatagca cagcctaggt ccccctatat aaggccacgg ctgctggccc ttcctttggg      480

tcagtgtcac ctccaggata cagacagccc cccttcagcc cagcccagcc aggtacggcg      540

cgccgtcgac ggatcccctt ttagagaatc cacacctgtc ccagttgctg ggttccacta      600

ccaaaagtga attgcaacta ttttaggagc acttaagcac atccgaaaaa tgagtgattc      660

tgttctggcc cacaccacat cactgatgta cccccttaaa gcatgtccct gagttcatca      720

cagaagactg ctcctcctgt gccctccaca aggttagaac tgtccttgtc ttagggaaaa      780

aggagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagggacagg      840

caccaactgg gtaacctctg ctgaccccca ctctacttta ccataagtag ctccaaatcc      900

ttctagaaaa tctgaaaggc atagccccat atatcagtga tataaataga acctgcagca      960

ggctctggta aatgatgact acaaggtgga ctgggaggca gcccggcctt ggcaggcatc     1020

atcctctaaa tataaagatg agtttgttca gcctttgcag aaggaggatc cgtcgacggc     1080

gcgccacgcg tcagtttact caccagggat tcagaggcag cactgctgaa ccctgagccc     1140

ttggcacatc aggttggctg tcagaagtcg gcctttgtac atacacagtt cccttgtgag     1200

gcccagctgc gtgtcctagg agcggggcct ctctccacag cagagctcag cctctcaagt     1260

gtatggacag cacgggtgcc tgatgggtgg atttagccat gagttgaagg tggcttgggg     1320

agaatgagag ttctagagat agggagaagg ggttgccaat aggagagtgg aattcctgag     1380

cacctcgtca caggcagccg acagaacatg agccgcaggg cccaggctat ttatacctcg     1440

cctgtcacta tcagggtccc cacagctccc cccacctcca gccacacaca gcaggtcctt     1500

ttgctctttc tggtcccttc tctactcctc cccctcccta cctaaggtac ccaacgcgtt     1560

acgtggccac cgccttcggc accatcctca cgacacccaa atatggcgac gggtgaggaa     1620

tggtggggag ttatttttag agcggtgagg aaggtgggca ggcagcaggt gttggcgctc     1680

taaaaataac tcccgggagt tatttttaga gcggaggaat ggtggacacc caaatatggc     1740

gacggttcct cacccgtcgc catatttggg tgtccgccct cggccggggc cgcattcctg     1800

ggggccgggc ggtgctcccg cccgcctcga taaaaggctc cggggccggc ggcggcccac     1860

gagctacccg gaggagcggg aggcgccaag ctctagatct agaaagaggt aagggtttaa     1920

gggatggttg gttggtgggg tattaatgtt taattacctg gagcacctgc ctgaaatcac     1980

tttttttcag gttggaagct tatggaagat gccaaaaaca ttaagaaggg cccagcgcca     2040

ttctacccac tcgaggacgg gaccgccggc gagcagctgc acaaagccat gaagcgctac     2100

gccctggtgc ccggcaccat cgcctttacc gacgcacata tcgaggtgga cattacctac     2160

gccgagtact tcgagatgag cgttcggctg gcagaagcta tgaagcgcta tgggctgaat     2220

acaaaccatc ggatcgtggt gtgcagcgag aatagcttgc agttcttcat gcccgtgttg     2280

ggtgccctgt tcatcggtgt ggctgtggcc ccagctaacg acatctacaa cgagcgcgag     2340

ctgctgaaca gcatgggcat cagccagccc accgtcgtat tcgtgagcaa gaaagggctg     2400

caaaagatcc tcaacgtgca aaagaagcta ccgatcatac aaaagatcat catcatggat     2460

agcaagaccg actaccaggg cttccaaagc atgtacacct tcgtgacttc ccatttgcca     2520

cccggcttca acgagtacga cttcgtgccc gagagcttcg accgggacaa aaccatcgcc     2580

ctgatcatga acagtagtgg cagtaccgga ttgcccaagg gcgtagccct accgcaccgc     2640

accgcttgtg tccgattcag tcatgcccgc gaccccatct tcggcaacca gatcatcccc     2700

gacaccgcta tcctcagcgt ggtgccattt caccacggct tcggcatgtt caccacgctg     2760

ggctacttga tctgcggctt tcgggtcgtg ctcatgtacc gcttcgagga ggagctattc     2820

ttgcgcagct tgcaagacta taagattcaa tctgccctgc tggtgcccac actatttagc     2880

ttcttcgcta agagcactct catcgacaag tacgacctaa gcaacttgca cgagatcgcc     2940

agcggcgggg cgccgctcag caaggaggta ggtgaggccg tggccaaacg cttccaccta     3000

ccaggcatcc gccagggcta cggcctgaca gaaacaacca gcgccattct gatcaccccc     3060

gaaggggacg acaagcctgg cgcagtaggc aaggtggtgc ccttcttcga ggctaaggtg     3120

gtggacttgg acaccggtaa gacactgggt gtgaaccagc gcggcgagct gtgcgtccgt     3180

ggccccatga tcatgagcgg ctacgttaac aaccccgagg ctacaaacgc tctcatcgac     3240

aaggacggct ggctgcacag cggcgacatc gcctactggg acgaggacga gcacttcttc     3300

atcgtggacc ggctgaagag cctgatcaaa tacaagggct accaggtagc cccagccgaa     3360

ctggagagca tcctgctgca acaccccaac atcttcgacg ccggggtcgc cggcctgccc     3420

gacgacgatg ccggcgagct gcccgccgca gtcgtcgtgc tggaacacgg taaaaccatg     3480

accgagaagg agatcgtgga ctatgtggcc agccaggtta caaccgccaa gaagctgcgc     3540

ggtggtgttg tgttcgtgga cgaggtgcct aaaggactga ccggcaagtt ggacgcccgc     3600

aagatccgcg agattctcat taaggccaag aagggcggca agatcgccgt gtaattcgaa     3660

acgtctagtc catcttgagc atctgacttc tggctaaata aaagatcttt attttcatta     3720

gatctgtgtg ttggtttttt gtgtgcgtcg agatccacgg ccgcaggaac ccctagtgat     3780

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3840

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct     3900

gcaggggcgc ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat     3960

acgtcaaagc aaccatagta cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     4020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     4080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     4140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgatttgggt     4200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     4260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4320

ggctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     4380

ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aattttatgg     4440

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca     4500

acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct     4560

gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg     4620

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt     4680

tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     4740

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     4800

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     4860

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     4920

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     4980

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     5040

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata     5100

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     5160

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     5220

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     5280

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     5340

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact     5400

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     5460

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     5520

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     5580

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     5640

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     5700

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     5760

atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     5820

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     5880

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     5940

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc     6000

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     6060

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     6120

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     6180

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     6240

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     6300

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     6360

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     6420

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     6480

tgctggcctt ttgctcacat gt                                              6502


<210>  40
<211>  6513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  40
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gcccctttta gagaatccac acctgtccca      180

gttgctgggt tccactacca aaagtgaatt gcaactattt taggagcact taagcacatc      240

cgaaaaatga gtgattctgt tctggcccac accacatcac tgatgtaccc ccttaaagca      300

tgtccctgag ttcatcacag aagactgctc ctcctgtgcc ctccacaagg ttagaactgt      360

ccttgtctta gggaaaaagg agagagagag agagagagag agagagagag agagagagag      420

agagagagag ggacaggcac caactgggta acctctgctg acccccactc tactttacca      480

taagtagctc caaatccttc tagaaaatct gaaaggcata gccccatata tcagtgatat      540

aaatagaacc tgcagcaggc tctggtaaat gatgactaca aggtggactg ggaggcagcc      600

cggccttggc aggcatcatc ctctaaatat aaagatgagt ttgttcagcc tttgcagaag      660

gaggcgcgcc gtcgacggat ccgggccagg ggacggtggc ttctacgtgc ttgggacgtt      720

cccagccacc gtcccatgtt cccggcgggg ggccagctgt ccccaccgcc agcccaactc      780

agcacttggt cagggtatca gcttggtggg ggggcgtgag cccagcccct ggggcggctc      840

agcccataca aggccatggg gctgggcgca aagcatgcct gggttcaggg tgggtatggt      900

gcgggagcag ggaggtgaga ggctcagctg ccctccagaa ctcctccctg gggacaaccc      960

ctcccagcca atagcacagc ctaggtcccc ctatataagg ccacggctgc tggcccttcc     1020

tttgggtcag tgtcacctcc aggatacaga cagcccccct tcagcccagc ccagccaggt     1080

acggatccgt cgacggcgcg ccacgcgtca gtttactcac cagggattca gaggcagcac     1140

tgctgaaccc tgagcccttg gcacatcagg ttggctgtca gaagtcggcc tttgtacata     1200

cacagttccc ttgtgaggcc cagctgcgtg tcctaggagc ggggcctctc tccacagcag     1260

agctcagcct ctcaagtgta tggacagcac gggtgcctga tgggtggatt tagccatgag     1320

ttgaaggtgg cttggggaga atgagagttc tagagatagg gagaaggggt tgccaatagg     1380

agagtggaat tcctgagcac ctcgtcacag gcagccgaca gaacatgagc cgcagggccc     1440

aggctattta tacctcgcct gtcactatca gggtccccac agctcccccc acctccagcc     1500

acacacagca ggtccttttg ctctttctgg tcccttctct actcctcccc ctccctacct     1560

aaggtaccca acgcgttacg tggccaccgc cttcggcacc atcctcacga cacccaaata     1620

tggcgacggg tgaggaatgg tggggagtta tttttagagc ggtgaggaag gtgggcaggc     1680

agcaggtgtt ggcgctctaa aaataactcc cgggagttat ttttagagcg gaggaatggt     1740

ggacacccaa atatggcgac ggttcctcac ccgtcgccat atttgggtgt ccgccctcgg     1800

ccggggccgc attcctgggg gccgggcggt gctcccgccc gcctcgataa aaggctccgg     1860

ggccggcggc ggcccacgag ctacccggag gagcgggagg cgccaagctc tagatctaga     1920

aagaggtaag ggtttaaggg atggttggtt ggtggggtat taatgtttaa ttacctggag     1980

cacctgcctg aaatcacttt ttttcaggtt ggaagcttat ggaagatgcc aaaaacatta     2040

agaagggccc agcgccattc tacccactcg aggacgggac cgccggcgag cagctgcaca     2100

aagccatgaa gcgctacgcc ctggtgcccg gcaccatcgc ctttaccgac gcacatatcg     2160

aggtggacat tacctacgcc gagtacttcg agatgagcgt tcggctggca gaagctatga     2220

agcgctatgg gctgaataca aaccatcgga tcgtggtgtg cagcgagaat agcttgcagt     2280

tcttcatgcc cgtgttgggt gccctgttca tcggtgtggc tgtggcccca gctaacgaca     2340

tctacaacga gcgcgagctg ctgaacagca tgggcatcag ccagcccacc gtcgtattcg     2400

tgagcaagaa agggctgcaa aagatcctca acgtgcaaaa gaagctaccg atcatacaaa     2460

agatcatcat catggatagc aagaccgact accagggctt ccaaagcatg tacaccttcg     2520

tgacttccca tttgccaccc ggcttcaacg agtacgactt cgtgcccgag agcttcgacc     2580

gggacaaaac catcgccctg atcatgaaca gtagtggcag taccggattg cccaagggcg     2640

tagccctacc gcaccgcacc gcttgtgtcc gattcagtca tgcccgcgac cccatcttcg     2700

gcaaccagat catccccgac accgctatcc tcagcgtggt gccatttcac cacggcttcg     2760

gcatgttcac cacgctgggc tacttgatct gcggctttcg ggtcgtgctc atgtaccgct     2820

tcgaggagga gctattcttg cgcagcttgc aagactataa gattcaatct gccctgctgg     2880

tgcccacact atttagcttc ttcgctaaga gcactctcat cgacaagtac gacctaagca     2940

acttgcacga gatcgccagc ggcggggcgc cgctcagcaa ggaggtaggt gaggccgtgg     3000

ccaaacgctt ccacctacca ggcatccgcc agggctacgg cctgacagaa acaaccagcg     3060

ccattctgat cacccccgaa ggggacgaca agcctggcgc agtaggcaag gtggtgccct     3120

tcttcgaggc taaggtggtg gacttggaca ccggtaagac actgggtgtg aaccagcgcg     3180

gcgagctgtg cgtccgtggc cccatgatca tgagcggcta cgttaacaac cccgaggcta     3240

caaacgctct catcgacaag gacggctggc tgcacagcgg cgacatcgcc tactgggacg     3300

aggacgagca cttcttcatc gtggaccggc tgaagagcct gatcaaatac aagggctacc     3360

aggtagcccc agccgaactg gagagcatcc tgctgcaaca ccccaacatc ttcgacgccg     3420

gggtcgccgg cctgcccgac gacgatgccg gcgagctgcc cgccgcagtc gtcgtgctgg     3480

aacacggtaa aaccatgacc gagaaggaga tcgtggacta tgtggccagc caggttacaa     3540

ccgccaagaa gctgcgcggt ggtgttgtgt tcgtggacga ggtgcctaaa ggactgaccg     3600

gcaagttgga cgcccgcaag atccgcgaga ttctcattaa ggccaagaag ggcggcaaga     3660

tcgccgtgta attcgaaacg tcacgtccat cttgagcatc tgacttctgg ctaaataaaa     3720

gatctttatt ttcattagat ctgtgtgttg gttttttgtg tgcgtcgaga tccacggccg     3780

caggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     3840

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     3900

cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt ttctccttac gcatctgtgc     3960

ggtatttcac accgcatacg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa     4020

gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc     4080

ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag     4140

ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca     4200

aaaaacttga tttgggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc     4260

gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa     4320

cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg atttcggcct     4380

attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa     4440

cgtttacaat tttatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     4500

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     4560

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     4620

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     4680

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     4740

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     4800

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     4860

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     4920

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     4980

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5040

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     5100

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5160

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5220

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5280

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5340

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt     5400

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5460

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5520

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     5580

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     5640

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     5700

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     5760

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     5820

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     5880

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     5940

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6000

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6060

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6120

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6180

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6240

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6300

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6360

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6420

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6480

tacggttcct ggccttttgc tggccttttg ctc                                  6513


<210>  41
<211>  6445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE06-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  41
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatccgg gccaggggac ggtggcttct acgtgcttgg gacgttccca gccaccgtcc      660

catgttcccg gcggggggcc agctgtcccc accgccagcc caactcagca cttggtcagg      720

gtatcagctt ggtggggggg cgtgagccca gcccctgggg cggctcagcc catacaaggc      780

catggggctg ggcgcaaagc atgcctgggt tcagggtggg tatggtgcgg gagcagggag      840

gtgagaggct cagctgccct ccagaactcc tccctgggga caacccctcc cagccaatag      900

cacagcctag gtccccctat ataaggccac ggctgctggc ccttcctttg ggtcagtgtc      960

acctccagga tacagacagc cccccttcag cccagcccag ccaggtacgg atccgtcgac     1020

ggcgcgccac gcgtcagttt actcaccagg gattcagagg cagcactgct gaaccctgag     1080

cccttggcac atcaggttgg ctgtcagaag tcggcctttg tacatacaca gttcccttgt     1140

gaggcccagc tgcgtgtcct aggagcgggg cctctctcca cagcagagct cagcctctca     1200

agtgtatgga cagcacgggt gcctgatggg tggatttagc catgagttga aggtggcttg     1260

gggagaatga gagttctaga gatagggaga aggggttgcc aataggagag tggaattcct     1320

gagcacctcg tcacaggcag ccgacagaac atgagccgca gggcccaggc tatttatacc     1380

tcgcctgtca ctatcagggt ccccacagct ccccccacct ccagccacac acagcaggtc     1440

cttttgctct ttctggtccc ttctctactc ctccccctcc ctacctaagg tacccaacgc     1500

gttacgtggc caccgccttc ggcaccatcc tcacgacacc caaatatggc gacgggtgag     1560

gaatggtggg gagttatttt tagagcggtg aggaaggtgg gcaggcagca ggtgttggcg     1620

ctctaaaaat aactcccggg agttattttt agagcggagg aatggtggac acccaaatat     1680

ggcgacggtt cctcacccgt cgccatattt gggtgtccgc cctcggccgg ggccgcattc     1740

ctgggggccg ggcggtgctc ccgcccgcct cgataaaagg ctccggggcc ggcggcggcc     1800

cacgagctac ccggaggagc gggaggcgcc aagctctaga tctagaaaga ggtaagggtt     1860

taagggatgg ttggttggtg gggtattaat gtttaattac ctggagcacc tgcctgaaat     1920

cacttttttt caggttggaa gcttatggaa gatgccaaaa acattaagaa gggcccagcg     1980

ccattctacc cactcgagga cgggaccgcc ggcgagcagc tgcacaaagc catgaagcgc     2040

tacgccctgg tgcccggcac catcgccttt accgacgcac atatcgaggt ggacattacc     2100

tacgccgagt acttcgagat gagcgttcgg ctggcagaag ctatgaagcg ctatgggctg     2160

aatacaaacc atcggatcgt ggtgtgcagc gagaatagct tgcagttctt catgcccgtg     2220

ttgggtgccc tgttcatcgg tgtggctgtg gccccagcta acgacatcta caacgagcgc     2280

gagctgctga acagcatggg catcagccag cccaccgtcg tattcgtgag caagaaaggg     2340

ctgcaaaaga tcctcaacgt gcaaaagaag ctaccgatca tacaaaagat catcatcatg     2400

gatagcaaga ccgactacca gggcttccaa agcatgtaca ccttcgtgac ttcccatttg     2460

ccacccggct tcaacgagta cgacttcgtg cccgagagct tcgaccggga caaaaccatc     2520

gccctgatca tgaacagtag tggcagtacc ggattgccca agggcgtagc cctaccgcac     2580

cgcaccgctt gtgtccgatt cagtcatgcc cgcgacccca tcttcggcaa ccagatcatc     2640

cccgacaccg ctatcctcag cgtggtgcca tttcaccacg gcttcggcat gttcaccacg     2700

ctgggctact tgatctgcgg ctttcgggtc gtgctcatgt accgcttcga ggaggagcta     2760

ttcttgcgca gcttgcaaga ctataagatt caatctgccc tgctggtgcc cacactattt     2820

agcttcttcg ctaagagcac tctcatcgac aagtacgacc taagcaactt gcacgagatc     2880

gccagcggcg gggcgccgct cagcaaggag gtaggtgagg ccgtggccaa acgcttccac     2940

ctaccaggca tccgccaggg ctacggcctg acagaaacaa ccagcgccat tctgatcacc     3000

cccgaagggg acgacaagcc tggcgcagta ggcaaggtgg tgcccttctt cgaggctaag     3060

gtggtggact tggacaccgg taagacactg ggtgtgaacc agcgcggcga gctgtgcgtc     3120

cgtggcccca tgatcatgag cggctacgtt aacaaccccg aggctacaaa cgctctcatc     3180

gacaaggacg gctggctgca cagcggcgac atcgcctact gggacgagga cgagcacttc     3240

ttcatcgtgg accggctgaa gagcctgatc aaatacaagg gctaccaggt agccccagcc     3300

gaactggaga gcatcctgct gcaacacccc aacatcttcg acgccggggt cgccggcctg     3360

cccgacgacg atgccggcga gctgcccgcc gcagtcgtcg tgctggaaca cggtaaaacc     3420

atgaccgaga aggagatcgt ggactatgtg gccagccagg ttacaaccgc caagaagctg     3480

cgcggtggtg ttgtgttcgt ggacgaggtg cctaaaggac tgaccggcaa gttggacgcc     3540

cgcaagatcc gcgagattct cattaaggcc aagaagggcg gcaagatcgc cgtgtaattc     3600

gaaacgtcaa gtccatcttg agcatctgac ttctggctaa ataaaagatc tttattttca     3660

ttagatctgt gtgttggttt tttgtgtgcg tcgagatcca cggccgcagg aacccctagt     3720

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     3780

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg     3840

cctgcagggg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg     3900

catacgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     3960

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     4020

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     4080

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg     4140

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     4200

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     4260

tcgggctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     4320

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta     4380

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     4440

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     4500

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4560

gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     4620

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     4680

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     4740

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     4800

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     4860

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     4920

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     4980

ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc     5040

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     5100

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     5160

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     5220

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     5280

aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta     5340

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     5400

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     5460

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     5520

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     5580

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     5640

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     5700

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     5760

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     5820

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     5880

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     5940

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     6000

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     6060

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     6120

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     6180

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     6240

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     6300

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     6360

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     6420

ttttgctggc cttttgctca catgt                                           6445


<210>  42
<211>  6554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  42
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgccgtcg      600

acggatcccc ttttagagaa tccacacctg tcccagttgc tgggttccac taccaaaagt      660

gaattgcaac tattttagga gcacttaagc acatccgaaa aatgagtgat tctgttctgg      720

cccacaccac atcactgatg taccccctta aagcatgtcc ctgagttcat cacagaagac      780

tgctcctcct gtgccctcca caaggttaga actgtccttg tcttagggaa aaaggagaga      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagggaca ggcaccaact      900

gggtaacctc tgctgacccc cactctactt taccataagt agctccaaat ccttctagaa      960

aatctgaaag gcatagcccc atatatcagt gatataaata gaacctgcag caggctctgg     1020

taaatgatga ctacaaggtg gactgggagg cagcccggcc ttggcaggca tcatcctcta     1080

aatataaaga tgagtttgtt cagcctttgc agaaggagga tccgtcgacg gcgcgccacg     1140

cgtcagttta ctcaccaggg attcagaggc agcactgctg aaccctgagc ccttggcaca     1200

tcaggttggc tgtcagaagt cggcctttgt acatacacag ttcccttgtg aggcccagct     1260

gcgtgtccta ggagcggggc ctctctccac agcagagctc agcctctcaa gtgtatggac     1320

agcacgggtg cctgatgggt ggatttagcc atgagttgaa ggtggcttgg ggagaatgag     1380

agttctagag atagggagaa ggggttgcca ataggagagt ggaattcctg agcacctcgt     1440

cacaggcagc cgacagaaca tgagccgcag ggcccaggct atttatacct cgcctgtcac     1500

tatcagggtc cccacagctc cccccacctc cagccacaca cagcaggtcc ttttgctctt     1560

tctggtccct tctctactcc tccccctccc tacctaaggt acccaacgcg ttacgtggcc     1620

accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg aatggtgggg     1680

agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc tctaaaaata     1740

actcccggga gttattttta gagcggagga atggtggaca cccaaatatg gcgacggttc     1800

ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg     1860

gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc acgagctacc     1920

cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt aagggatggt     1980

tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc actttttttc     2040

aggttggaag cttatggaag atgccaaaaa cattaagaag ggcccagcgc cattctaccc     2100

actcgaggac gggaccgccg gcgagcagct gcacaaagcc atgaagcgct acgccctggt     2160

gcccggcacc atcgccttta ccgacgcaca tatcgaggtg gacattacct acgccgagta     2220

cttcgagatg agcgttcggc tggcagaagc tatgaagcgc tatgggctga atacaaacca     2280

tcggatcgtg gtgtgcagcg agaatagctt gcagttcttc atgcccgtgt tgggtgccct     2340

gttcatcggt gtggctgtgg ccccagctaa cgacatctac aacgagcgcg agctgctgaa     2400

cagcatgggc atcagccagc ccaccgtcgt attcgtgagc aagaaagggc tgcaaaagat     2460

cctcaacgtg caaaagaagc taccgatcat acaaaagatc atcatcatgg atagcaagac     2520

cgactaccag ggcttccaaa gcatgtacac cttcgtgact tcccatttgc cacccggctt     2580

caacgagtac gacttcgtgc ccgagagctt cgaccgggac aaaaccatcg ccctgatcat     2640

gaacagtagt ggcagtaccg gattgcccaa gggcgtagcc ctaccgcacc gcaccgcttg     2700

tgtccgattc agtcatgccc gcgaccccat cttcggcaac cagatcatcc ccgacaccgc     2760

tatcctcagc gtggtgccat ttcaccacgg cttcggcatg ttcaccacgc tgggctactt     2820

gatctgcggc tttcgggtcg tgctcatgta ccgcttcgag gaggagctat tcttgcgcag     2880

cttgcaagac tataagattc aatctgccct gctggtgccc acactattta gcttcttcgc     2940

taagagcact ctcatcgaca agtacgacct aagcaacttg cacgagatcg ccagcggcgg     3000

ggcgccgctc agcaaggagg taggtgaggc cgtggccaaa cgcttccacc taccaggcat     3060

ccgccagggc tacggcctga cagaaacaac cagcgccatt ctgatcaccc ccgaagggga     3120

cgacaagcct ggcgcagtag gcaaggtggt gcccttcttc gaggctaagg tggtggactt     3180

ggacaccggt aagacactgg gtgtgaacca gcgcggcgag ctgtgcgtcc gtggccccat     3240

gatcatgagc ggctacgtta acaaccccga ggctacaaac gctctcatcg acaaggacgg     3300

ctggctgcac agcggcgaca tcgcctactg ggacgaggac gagcacttct tcatcgtgga     3360

ccggctgaag agcctgatca aatacaaggg ctaccaggta gccccagccg aactggagag     3420

catcctgctg caacacccca acatcttcga cgccggggtc gccggcctgc ccgacgacga     3480

tgccggcgag ctgcccgccg cagtcgtcgt gctggaacac ggtaaaacca tgaccgagaa     3540

ggagatcgtg gactatgtgg ccagccaggt tacaaccgcc aagaagctgc gcggtggtgt     3600

tgtgttcgtg gacgaggtgc ctaaaggact gaccggcaag ttggacgccc gcaagatccg     3660

cgagattctc attaaggcca agaagggcgg caagatcgcc gtgtaattcg aaacgtcaag     3720

tccatcttga gcatctgact tctggctaaa taaaagatct ttattttcat tagatctgtg     3780

tgttggtttt ttgtgtgcgt cgagatccac ggccgcagga acccctagtg atggagttgg     3840

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3900

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc     3960

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa     4020

gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     4080

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4140

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4200

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc     4260

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4320

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cgggctattc     4380

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     4440

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaattttat ggtgcactct     4500

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     4560

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     4620

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     4680

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac     4740

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat     4800

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg     4860

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc     4920

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga     4980

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga     5040

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg     5100

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc     5160

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac     5220

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact     5280

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca     5340

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg     5400

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact     5460

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg     5520

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg     5580

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat     5640

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc     5700

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat     5760

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt     5820

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     5880

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     5940

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     6000

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt     6060

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     6120

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     6180

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     6240

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg     6300

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt     6360

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc     6420

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg     6480

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc     6540

ttttgctcac atgt                                                       6554


<210>  43
<211>  6986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-CRE02-CRE04-CRE06-CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  43
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggccgaca ggtgcggttc ccggagcgca ggcgcacaca tgcacccacc      180

ggcgaacgcg gtgaccctcg ccccacccca tcccctccgg cgggcaactg ggtcgggtca      240

ggaggggcaa acccgctagg gagacactcc atatacggcc cggcccgcgt tacctgggac      300

cgggccaacc cgctccttct ttggtcaacg caggggaccc gggcgggggc ccaggccgcg      360

aaccggccga gggagggggc tctagtgccc aacacccaaa tatggctcga gaagggcagc      420

gacattcctg cggggtggcg cggagggaat gcccgcgggc tatataaaac ctgagcagag      480

ggacaagcgg ccaccgcagc ggacagcgcc aagtgaagcc tcgcttcccc tccgcggcga      540

ccagggcccg agccgagagt agcagttgta gctacccgcc caggtagggg cgcgcccgta      600

cggtcgacgg atcccctttt agagaatcca cacctgtccc agttgctggg ttccactacc      660

aaaagtgaat tgcaactatt ttaggagcac ttaagcacat ccgaaaaatg agtgattctg      720

ttctggccca caccacatca ctgatgtacc cccttaaagc atgtccctga gttcatcaca      780

gaagactgct cctcctgtgc cctccacaag gttagaactg tccttgtctt agggaaaaag      840

gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gggacaggca      900

ccaactgggt aacctctgct gacccccact ctactttacc ataagtagct ccaaatcctt      960

ctagaaaatc tgaaaggcat agccccatat atcagtgata taaatagaac ctgcagcagg     1020

ctctggtaaa tgatgactac aaggtggact gggaggcagc ccggccttgg caggcatcat     1080

cctctaaata taaagatgag tttgttcagc ctttgcagaa ggaggcgcgc cgtcgacgga     1140

tccgggccag gggacggtgg cttctacgtg cttgggacgt tcccagccac cgtcccatgt     1200

tcccggcggg gggccagctg tccccaccgc cagcccaact cagcacttgg tcagggtatc     1260

agcttggtgg gggggcgtga gcccagcccc tggggcggct cagcccatac aaggccatgg     1320

ggctgggcgc aaagcatgcc tgggttcagg gtgggtatgg tgcgggagca gggaggtgag     1380

aggctcagct gccctccaga actcctccct ggggacaacc cctcccagcc aatagcacag     1440

cctaggtccc cctatataag gccacggctg ctggcccttc ctttgggtca gtgtcacctc     1500

caggatacag acagcccccc ttcagcccag cccagccagg tacggatccg tcgaccgtac     1560

gggcgcgcca cgcgtcagtt tactcaccag ggattcagag gcagcactgc tgaaccctga     1620

gcccttggca catcaggttg gctgtcagaa gtcggccttt gtacatacac agttcccttg     1680

tgaggcccag ctgcgtgtcc taggagcggg gcctctctcc acagcagagc tcagcctctc     1740

aagtgtatgg acagcacggg tgcctgatgg gtggatttag ccatgagttg aaggtggctt     1800

ggggagaatg agagttctag agatagggag aaggggttgc caataggaga gtggaattcc     1860

tgagcacctc gtcacaggca gccgacagaa catgagccgc agggcccagg ctatttatac     1920

ctcgcctgtc actatcaggg tccccacagc tccccccacc tccagccaca cacagcaggt     1980

ccttttgctc tttctggtcc cttctctact cctccccctc cctacctaag gtacccaacg     2040

cgttacgtgg ccaccgcctt cggcaccatc ctcacgacac ccaaatatgg cgacgggtga     2100

ggaatggtgg ggagttattt ttagagcggt gaggaaggtg ggcaggcagc aggtgttggc     2160

gctctaaaaa taactcccgg gagttatttt tagagcggag gaatggtgga cacccaaata     2220

tggcgacggt tcctcacccg tcgccatatt tgggtgtccg ccctcggccg gggccgcatt     2280

cctgggggcc gggcggtgct cccgcccgcc tcgataaaag gctccggggc cggcggcggc     2340

ccacgagcta cccggaggag cgggaggcgc caagctctag atctagaaag aggtaagggt     2400

ttaagggatg gttggttggt ggggtattaa tgtttaatta cctggagcac ctgcctgaaa     2460

tcactttttt tcaggttgga agcttatgga agatgccaaa aacattaaga agggcccagc     2520

gccattctac ccactcgagg acgggaccgc cggcgagcag ctgcacaaag ccatgaagcg     2580

ctacgccctg gtgcccggca ccatcgcctt taccgacgca catatcgagg tggacattac     2640

ctacgccgag tacttcgaga tgagcgttcg gctggcagaa gctatgaagc gctatgggct     2700

gaatacaaac catcggatcg tggtgtgcag cgagaatagc ttgcagttct tcatgcccgt     2760

gttgggtgcc ctgttcatcg gtgtggctgt ggccccagct aacgacatct acaacgagcg     2820

cgagctgctg aacagcatgg gcatcagcca gcccaccgtc gtattcgtga gcaagaaagg     2880

gctgcaaaag atcctcaacg tgcaaaagaa gctaccgatc atacaaaaga tcatcatcat     2940

ggatagcaag accgactacc agggcttcca aagcatgtac accttcgtga cttcccattt     3000

gccacccggc ttcaacgagt acgacttcgt gcccgagagc ttcgaccggg acaaaaccat     3060

cgccctgatc atgaacagta gtggcagtac cggattgccc aagggcgtag ccctaccgca     3120

ccgcaccgct tgtgtccgat tcagtcatgc ccgcgacccc atcttcggca accagatcat     3180

ccccgacacc gctatcctca gcgtggtgcc atttcaccac ggcttcggca tgttcaccac     3240

gctgggctac ttgatctgcg gctttcgggt cgtgctcatg taccgcttcg aggaggagct     3300

attcttgcgc agcttgcaag actataagat tcaatctgcc ctgctggtgc ccacactatt     3360

tagcttcttc gctaagagca ctctcatcga caagtacgac ctaagcaact tgcacgagat     3420

cgccagcggc ggggcgccgc tcagcaagga ggtaggtgag gccgtggcca aacgcttcca     3480

cctaccaggc atccgccagg gctacggcct gacagaaaca accagcgcca ttctgatcac     3540

ccccgaaggg gacgacaagc ctggcgcagt aggcaaggtg gtgcccttct tcgaggctaa     3600

ggtggtggac ttggacaccg gtaagacact gggtgtgaac cagcgcggcg agctgtgcgt     3660

ccgtggcccc atgatcatga gcggctacgt taacaacccc gaggctacaa acgctctcat     3720

cgacaaggac ggctggctgc acagcggcga catcgcctac tgggacgagg acgagcactt     3780

cttcatcgtg gaccggctga agagcctgat caaatacaag ggctaccagg tagccccagc     3840

cgaactggag agcatcctgc tgcaacaccc caacatcttc gacgccgggg tcgccggcct     3900

gcccgacgac gatgccggcg agctgcccgc cgcagtcgtc gtgctggaac acggtaaaac     3960

catgaccgag aaggagatcg tggactatgt ggccagccag gttacaaccg ccaagaagct     4020

gcgcggtggt gttgtgttcg tggacgaggt gcctaaagga ctgaccggca agttggacgc     4080

ccgcaagatc cgcgagattc tcattaaggc caagaagggc ggcaagatcg ccgtgtaatt     4140

cgaaacgtca agtccatctt gagcatctga cttctggcta aataaaagat ctttattttc     4200

attagatctg tgtgttggtt ttttgtgtgc gtcgagatcc acggccgcag gaacccctag     4260

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     4320

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct     4380

gcctgcaggg gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     4440

gcatacgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     4500

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     4560

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     4620

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgattt     4680

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     4740

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     4800

ctcgggctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     4860

tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt ttacaatttt     4920

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc     4980

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca     5040

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg     5100

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat     5160

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt     5220

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct     5280

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc     5340

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     5400

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     5460

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     5520

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     5580

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     5640

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     5700

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     5760

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     5820

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     5880

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     5940

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     6000

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     6060

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     6120

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     6180

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     6240

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     6300

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     6360

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     6420

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     6480

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     6540

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     6600

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     6660

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     6720

gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     6780

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     6840

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     6900

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     6960

cttttgctgg ccttttgctc acatgt                                          6986


<210>  44
<211>  4428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV- SPc5-12-MVM-h-SG-pA

<400>  44
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtggt acccaacgcg      180

ttacgtggcc accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg      240

aatggtgggg agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc      300

tctaaaaata actcccggga gttattttta gagcggagga atggtggaca cccaaatatg      360

gcgacggttc ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc      420

tgggggccgg gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc      480

acgagctacc cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt      540

aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc      600

actttttttc aggttggaag cttgccacca tggcggcagc ggcggcggcg gctgcagaac      660

agcaaagttc caatggtcct gtaaagaagt ccatgcgtga gaaggctgtt gagagaagga      720

gtgtcaataa agagcacaac agtaacttta aagctggata cattccgatt gatgaagatc      780

gtctccacaa aacagggttg agaggaagaa agggcaattt agccatctgt gtgattatcc      840

tcttgtttat cctggctgtc atcaatttaa taataacact tgttatttgg gccgtgattc      900

gcattggacc aaatggctgt gatagtatgg agtttcatga aagtggcctg cttcgattta      960

agcaagtatc tgacatggga gtgatccacc ctctttataa aagcacagta ggaggaaggc     1020

gaaatgaaaa tttggtcatc actggcaaca accagcctat tgtttttcag caagggacaa     1080

caaagctcag tgtagaaaac aacaaaactt ctattacaag tgacatcggc atgcagtttt     1140

ttgacccgag gactcaaaat atcttattca gcacagacta tgaaactcat gagtttcatt     1200

tgccaagtgg agtgaaaagt ttgaatgttc aaaaggcatc tactgaaagg attaccagca     1260

atgctaccag tgatttaaat ataaaagttg atgggcgtgc tattgtgcgt ggaaatgaag     1320

gtgtattcat tatgggcaaa accattgaat ttcacatggg tggtaatatg gagttaaagg     1380

cggaaaacag tatcatccta aatggatctg tgatggtcag caccacccgc ctacccagtt     1440

cctccagtgg agaccagttg ggtagtggtg actgggtacg ctacaagctc tgcatgtgtg     1500

ctgatgggac gctcttcaag gtgcaagtaa ccagccagaa catgggctgc caaatctcag     1560

acaacccctg tggaaacact cattaattcg aaacgttgtg tccatcttga gcatctgact     1620

tctggctaaa taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtgcgt     1680

cgagatccac ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct     1740

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     1800

gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc     1860

cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct     1920

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg     1980

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     2040

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac     2100

ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct     2160

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     2220

tccaaactgg aacaacactc aaccctatct cgggctattc ttttgattta taagggattt     2280

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     2340

ttaacaaaat attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg     2400

ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt     2460

gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc     2520

agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat     2580

ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg     2640

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     2700

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     2760

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     2820

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg     2880

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac     2940

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg     3000

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt     3060

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg     3120

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac     3180

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt     3240

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag     3300

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc     3360

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc     3420

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta     3480

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg     3540

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga     3600

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac     3660

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     3720

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     3780

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     3840

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     3900

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc     3960

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     4020

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     4080

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     4140

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     4200

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     4260

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     4320

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     4380

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctc                  4428


<210>  45
<211>  4428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV- SPc5-12-MVM-h-SGco-pA

<400>  45
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtggt acccaacgcg      180

ttacgtggcc accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg      240

aatggtgggg agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc      300

tctaaaaata actcccggga gttattttta gagcggagga atggtggaca cccaaatatg      360

gcgacggttc ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc      420

tgggggccgg gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc      480

acgagctacc cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt      540

aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc      600

actttttttc aggttggaag cttgccacca tggctgctgc cgctgctgct gcagctgaac      660

agcaatctag caacggcccc gtgaagaaat ccatgcgcga gaaggccgtc gagcggagat      720

ctgtgaacaa agagcacaac agcaacttca aggccggcta catccccatc gacgaggaca      780

gactgcacaa gacaggcctg agaggcagaa agggcaatct ggccatctgc gtgatcatcc      840

tgctgttcat cctggccgtg atcaacctga tcatcaccct ggtcatctgg gccgtgatta      900

gaatcggccc caacggctgc gacagcatgg aatttcacga gagcggcctg ctgcggttca      960

aacaggtgtc cgatatgggc gtgatccatc cactgtacaa gagcaccgtt ggcggcagaa     1020

gaaacgagaa tctggtcatc accggcaaca accagcctat cgtgtttcag cagggcacca     1080

ccaagctgag cgtggaaaac aacaagacca gcatcaccag cgacatcggc atgcagttct     1140

tcgaccccag aacacagaac atcctgttca gcaccgacta cgagacacac gagttccatc     1200

tgcctagcgg cgtgaagtcc ctgaatgtgc agaaggccag caccgagaga atcaccagca     1260

atgccacctc cgacctgaac atcaaagtgg acggcagagc catcgtgcgg ggaaatgagg     1320

gcgtgttcat catgggcaag accatcgagt tccacatggg cggcaacatg gaactgaagg     1380

ccgagaacag catcatcctg aacggcagcg tgatggtgtc caccacaaga ctgccaagca     1440

gcagctctgg cgatcagctt ggatctggcg actgggtccg atacaagctg tgtatgtgtg     1500

ccgacggcac cctgttcaag gtgcaagtga caagccagaa catgggctgc cagatcagcg     1560

acaacccttg cggcaatacc cactgattcg aaacgttgtg tccatcttga gcatctgact     1620

tctggctaaa taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtgcgt     1680

cgagatccac ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct     1740

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     1800

gcctcagtga gcgagcgagc gcgcagctgc ctgcaggggc gcctgatgcg gtattttctc     1860

cttacgcatc tgtgcggtat ttcacaccgc atacgtcaaa gcaaccatag tacgcgccct     1920

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg     1980

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     2040

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac     2100

ggcacctcga ccccaaaaaa cttgatttgg gtgatggttc acgtagtggg ccatcgccct     2160

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     2220

tccaaactgg aacaacactc aaccctatct cgggctattc ttttgattta taagggattt     2280

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     2340

ttaacaaaat attaacgttt acaattttat ggtgcactct cagtacaatc tgctctgatg     2400

ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt     2460

gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc     2520

agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat     2580

ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg     2640

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc     2700

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta     2760

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg     2820

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg     2880

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac     2940

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg     3000

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt     3060

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg     3120

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac     3180

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt     3240

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag     3300

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc     3360

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc     3420

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta     3480

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg     3540

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga     3600

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac     3660

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     3720

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     3780

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     3840

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     3900

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc     3960

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     4020

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     4080

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     4140

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     4200

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     4260

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     4320

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     4380

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctc                  4428


<210>  46
<211>  5118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV-SPc5-12-MVM-Luc-pA

<400>  46
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtggt acccaacgcg      180

ttacgtggcc accgccttcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg      240

aatggtgggg agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc      300

tctaaaaata actcccggga gttattttta gagcggagga atggtggaca cccaaatatg      360

gcgacggttc ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc      420

tgggggccgg gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc      480

acgagctacc cggaggagcg ggaggcgcca agctctagat ctagaaagag gtaagggttt      540

aagggatggt tggttggtgg ggtattaatg tttaattacc tggagcacct gcctgaaatc      600

actttttttc aggttggaag cttatggaag atgccaaaaa cattaagaag ggcccagcgc      660

cattctaccc actcgaagac gggaccgccg gcgagcagct gcacaaagcc atgaagcgct      720

acgccctggt gcccggcacc atcgccttta ccgacgcaca tatcgaggtg gacattacct      780

acgccgagta cttcgagatg agcgttcggc tggcagaagc tatgaagcgc tatgggctga      840

atacaaacca tcggatcgtg gtgtgcagcg agaatagctt gcagttcttc atgcccgtgt      900

tgggtgccct gttcatcggt gtggctgtgg ccccagctaa cgacatctac aacgagcgcg      960

agctgctgaa cagcatgggc atcagccagc ccaccgtcgt attcgtgagc aagaaagggc     1020

tgcaaaagat cctcaacgtg caaaagaagc taccgatcat acaaaagatc atcatcatgg     1080

atagcaagac cgactaccag ggcttccaaa gcatgtacac cttcgtgact tcccatttgc     1140

cacccggctt caacgagtac gacttcgtgc ccgagagctt cgaccgggac aaaaccatcg     1200

ccctgatcat gaacagtagt ggcagtaccg gattgcccaa gggcgtagcc ctaccgcacc     1260

gcaccgcttg tgtccgattc agtcatgccc gcgaccccat cttcggcaac cagatcatcc     1320

ccgacaccgc tatcctcagc gtggtgccat ttcaccacgg cttcggcatg ttcaccacgc     1380

tgggctactt gatctgcggc tttcgggtcg tgctcatgta ccgcttcgag gaggagctat     1440

tcttgcgcag cttgcaagac tataagattc aatctgccct gctggtgccc acactattta     1500

gcttcttcgc taagagcact ctcatcgaca agtacgacct aagcaacttg cacgagatcg     1560

ccagcggcgg ggcgccgctc agcaaggagg taggtgaggc cgtggccaaa cgcttccacc     1620

taccaggcat ccgccagggc tacggcctga cagaaacaac cagcgccatt ctgatcaccc     1680

ccgaagggga cgacaagcct ggcgcagtag gcaaggtggt gcccttcttc gaggctaagg     1740

tggtggactt ggacaccggt aagacactgg gtgtgaacca gcgcggcgag ctgtgcgtcc     1800

gtggccccat gatcatgagc ggctacgtta acaaccccga ggctacaaac gctctcatcg     1860

acaaggacgg ctggctgcac agcggcgaca tcgcctactg ggacgaggac gagcacttct     1920

tcatcgtgga ccggctgaag agcctgatca aatacaaggg ctaccaggta gccccagccg     1980

aactggagag catcctgctg caacacccca acatcttcga cgccggggtc gccggcctgc     2040

ccgacgacga tgccggcgag ctgcccgccg cagtcgtcgt gctggaacac ggtaaaacca     2100

tgaccgagaa ggagatcgtg gactatgtgg ccagccaggt tacaaccgcc aagaagctgc     2160

gcggtggtgt tgtgttcgtg gacgaggtgc ctaaaggact gaccggcaag ttggacgccc     2220

gcaagatccg cgagattctc attaaggcca agaagggcgg caagatcgcc gtgtaattcg     2280

aaacgttgtg tccatcttga gcatctgact tctggctaaa taaaagatct ttattttcat     2340

tagatctgtg tgttggtttt ttgtgtgcgt cgagatccac ggccgcagga acccctagtg     2400

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     2460

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc     2520

ctgcaggggc gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     2580

atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     2640

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     2700

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     2760

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgatttgg     2820

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     2880

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     2940

cgggctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     3000

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaattttat     3060

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     3120

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     3180

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     3240

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     3300

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     3360

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     3420

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     3480

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     3540

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     3600

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     3660

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     3720

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     3780

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     3840

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     3900

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     3960

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     4020

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     4080

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     4140

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     4200

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     4260

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     4320

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     4380

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     4440

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     4500

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     4560

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     4620

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     4680

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     4740

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     4800

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     4860

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     4920

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     4980

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     5040

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     5100

tttgctggcc ttttgctc                                                   5118


<210>  47
<211>  5572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV- CSK-SH5-SPc5-12-MVM-Luc-pA

<400>  47
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggcgcgc cacgcgtcag tttactcacc      180

agggattcag aggcagcact gctgaaccct gagcccttgg cacatcaggt tggctgtcag      240

aagtcggcct ttgtacatac acagttccct tgtgaggccc agctgcgtgt cctaggagcg      300

gggcctctct ccacagcaga gctcagcctc tcaagtgtat ggacagcacg ggtgcctgat      360

gggtggattt agccatgagt tgaaggtggc ttggggagaa tgagagttct agagataggg      420

agaaggggtt gccaatagga gagtggaatt cctgagcacc tcgtcacagg cagccgacag      480

aacatgagcc gcagggccca ggctatttat acctcgcctg tcactatcag ggtccccaca      540

gctcccccca cctccagcca cacacagcag gtccttttgc tctttctggt cccttctcta      600

ctcctccccc tccctaccta aggtacccaa cgcgttacgt ggccaccgcc ttcggcacca      660

tcctcacgac acccaaatat ggcgacgggt gaggaatggt ggggagttat ttttagagcg      720

gtgaggaagg tgggcaggca gcaggtgttg gcgctctaaa aataactccc gggagttatt      780

tttagagcgg aggaatggtg gacacccaaa tatggcgacg gttcctcacc cgtcgccata      840

tttgggtgtc cgccctcggc cggggccgca ttcctggggg ccgggcggtg ctcccgcccg      900

cctcgataaa aggctccggg gccggcggcg gcccacgagc tacccggagg agcgggaggc      960

gccaagctct agatctagaa agaggtaagg gtttaaggga tggttggttg gtggggtatt     1020

aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg gaagcttatg     1080

gaagatgcca aaaacattaa gaagggccca gcgccattct acccactcga ggacgggacc     1140

gccggcgagc agctgcacaa agccatgaag cgctacgccc tggtgcccgg caccatcgcc     1200

tttaccgacg cacatatcga ggtggacatt acctacgccg agtacttcga gatgagcgtt     1260

cggctggcag aagctatgaa gcgctatggg ctgaatacaa accatcggat cgtggtgtgc     1320

agcgagaata gcttgcagtt cttcatgccc gtgttgggtg ccctgttcat cggtgtggct     1380

gtggccccag ctaacgacat ctacaacgag cgcgagctgc tgaacagcat gggcatcagc     1440

cagcccaccg tcgtattcgt gagcaagaaa gggctgcaaa agatcctcaa cgtgcaaaag     1500

aagctaccga tcatacaaaa gatcatcatc atggatagca agaccgacta ccagggcttc     1560

caaagcatgt acaccttcgt gacttcccat ttgccacccg gcttcaacga gtacgacttc     1620

gtgcccgaga gcttcgaccg ggacaaaacc atcgccctga tcatgaacag tagtggcagt     1680

accggattgc ccaagggcgt agccctaccg caccgcaccg cttgtgtccg attcagtcat     1740

gcccgcgacc ccatcttcgg caaccagatc atccccgaca ccgctatcct cagcgtggtg     1800

ccatttcacc acggcttcgg catgttcacc acgctgggct acttgatctg cggctttcgg     1860

gtcgtgctca tgtaccgctt cgaggaggag ctattcttgc gcagcttgca agactataag     1920

attcaatctg ccctgctggt gcccacacta tttagcttct tcgctaagag cactctcatc     1980

gacaagtacg acctaagcaa cttgcacgag atcgccagcg gcggggcgcc gctcagcaag     2040

gaggtaggtg aggccgtggc caaacgcttc cacctaccag gcatccgcca gggctacggc     2100

ctgacagaaa caaccagcgc cattctgatc acccccgaag gggacgacaa gcctggcgca     2160

gtaggcaagg tggtgccctt cttcgaggct aaggtggtgg acttggacac cggtaagaca     2220

ctgggtgtga accagcgcgg cgagctgtgc gtccgtggcc ccatgatcat gagcggctac     2280

gttaacaacc ccgaggctac aaacgctctc atcgacaagg acggctggct gcacagcggc     2340

gacatcgcct actgggacga ggacgagcac ttcttcatcg tggaccggct gaagagcctg     2400

atcaaataca agggctacca ggtagcccca gccgaactgg agagcatcct gctgcaacac     2460

cccaacatct tcgacgccgg ggtcgccggc ctgcccgacg acgatgccgg cgagctgccc     2520

gccgcagtcg tcgtgctgga acacggtaaa accatgaccg agaaggagat cgtggactat     2580

gtggccagcc aggttacaac cgccaagaag ctgcgcggtg gtgttgtgtt cgtggacgag     2640

gtgcctaaag gactgaccgg caagttggac gcccgcaaga tccgcgagat tctcattaag     2700

gccaagaagg gcggcaagat cgccgtgtaa ttcgaaacgt tcggtccatc ttgagcatct     2760

gacttctggc taaataaaag atctttattt tcattagatc tgtgtgttgg ttttttgtgt     2820

gcgtcgagat ccacggccgc aggaacccct agtgatggag ttggccactc cctctctgcg     2880

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     2940

ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag gggcgcctga tgcggtattt     3000

tctccttacg catctgtgcg gtatttcaca ccgcatacgt caaagcaacc atagtacgcg     3060

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     3120

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     3180

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     3240

ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg gttcacgtag tgggccatcg     3300

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     3360

ttgttccaaa ctggaacaac actcaaccct atctcgggct attcttttga tttataaggg     3420

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     3480

aattttaaca aaatattaac gtttacaatt ttatggtgca ctctcagtac aatctgctct     3540

gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg     3600

gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg     3660

tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc     3720

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     3780

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     3840

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     3900

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     3960

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     4020

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     4080

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     4140

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     4200

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     4260

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     4320

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     4380

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     4440

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     4500

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     4560

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     4620

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     4680

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     4740

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     4800

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     4860

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     4920

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     4980

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     5040

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     5100

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     5160

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     5220

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     5280

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     5340

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     5400

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     5460

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     5520

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tc             5572


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Luc Forward primer for titration

<400>  48
cccaccgtcg tattcgtgag                                                   20


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Luc Reverse primer for titration

<400>  49
tcagggcgat ggttttgtcc c                                                 21


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-sarcoglycan Forward primer for titration

<400>  50
agggatggtt ggttggtgg                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-sarcoglycan Reverse primer for titration

<400>  51
ggcaggtgct ccaggtaat                                                    19


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-sarcoglycan Forward primer for RT-PCR

<400>  52
catcacaagt gacatcggca                                                   20


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-sarcoglycan Reverse primer for RT-PCR

<400>  53
tggcagccca tgttctggc                                                    19


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH Forward primer for RT-PCR

<400>  54
tgtgtccgtc gtggatctga                                                   20


<210>  55
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH Reverse primer for RT-PCR

<400>  55
gcctgcttca ccaccttctt ga                                                22


<210>  56
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MHCK7 promoter

<400>  56
tagttcatag cccatatatg gagttccgct agaagctgca tgtctaagct agacccttca       60

gattaaaaat aactgaggta agggcctggg taggggaggt ggtgtgagac gctcctgtct      120

ctcctctatc tgcccatcgg ccctttgggg aggaggaatg tgcccaagga ctaaaaaaag      180

gccatggagc cagaggggcg agggcaacag acctttcatg ggcaaacctt ggggccctgc      240

tgtctagcat gccccactac gggtctaggc tgcccatgta aggaggcaag gcctggggac      300

acccgagatg cctggttata attaacccag acatgtggct gccccccccc ccccaacacc      360

tgctgcctct aaaaataacc ctgtccctgg tggatcccct gcatgcgaag atcttcgaac      420

aaggctgtgg gggactgagg gcaggctgta acaggcttgg gggccagggc ttatacgtgc      480

ctgggactcc caaagtatta ctgttccatg ttcccggcga agggccagct gtcccccgcc      540

agctagactc agcacttagt ttaggaacca gtgagcaagt cagcccttgg ggcagcccat      600

acaaggccat ggggctgggc aagctgcacg cctgggtccg gggtgggcac ggtgcccggg      660

caacgagctg aaagctcatc tgctctcagg ggcccctccc tggggacagc ccctcctggc      720

tagtcacacc ctgtaggctc ctctatataa cccaggggca caggggctgc cctcattcta      780

ccaccacctc cacagcac                                                    798


<210>  57
<211>  1426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  desmin promoter

<400>  57
acacacctac tagtaacccc tccagctggt gatggcaggt ctagggtagg accagtgact       60

ggctcctaat cgagcactct attttcaggg tttgcattcc aaaagggtca ggtccaagag      120

ggacctggag tgccaagtgg aggtgtagag gcacggccag tacccatgga gaatggtgga      180

tgtccttagg ggttagcaag tgccgtgtgc taaggagggg gctttggagg ttgggcaggc      240

cctctgtggg gctccatttt tgtgggggtg ggggctggag cattataggg ggtgggaagt      300

gattggggct gtcaccctag ccttccttat ctgacgccca cccatgcctc ctcaggtacc      360

ccctgccccc cacagctcct ctcctgtgcc ttgtttccca gccatgcgtt ctcctctata      420

aatacccgct ctggtatttg gggttggcag ctgttgctgc cagggagatg gttgggttga      480

catgcggctc ctgacaaaac acaaacccct ggtgtgtgtg ggcgtgggtg gtgtgagtag      540

ggggatgaat cagggagggg gcgggggacc cagggggcag gagccacaca aagtctgtgc      600

gggggtggga gcgcacatag caattggaaa ctgaaagctt atcagaccct ttctggaaat      660

cagcccactg tttataaact tgaggcccca ccctcgacag taccggggag gaagagggcc      720

tgcactagtc cagagggaaa ctgaggctca gggctagctc gcccatagac atacatggca      780

ggcaggcttt ggccaggatc cctccgcctg ccaggcgtct ccctgccctc ccttcctgcc      840

tagagacccc caccctcaag cctggctggt ctttgcctga gacccaaacc tcttcgactt      900

caagagaata tttaggaaca aggtggttta gggcctttcc tgggaacagg ccttgaccct      960

ttaagaaatg acccaaagtc tctccttgac caaaaagggg accctcaaac taaagggaag     1020

cctctcttct gctgtctccc ctgaccccac tcccccccac cccaggacga ggagataacc     1080

agggctgaaa gaggcccgcc tgggggctgc agacatgctt gctgcctgcc ctggcgaagg     1140

attggcaggc ttgcccgtca caggaccccc gctggctgac tcaggggcgc aggcctcttg     1200

cgggggagct ggcctccccg cccccacggc cacgggccgc cctttcctgg caggacagcg     1260

ggatcttgca gctgtcaggg gaggggaggc gggggctgat gtcaggaggg atacaaatag     1320

tgccgacggc tgggggccct gtctcccctc gccgcatcca ctctccggcc ggccgcctgc     1380

ccgccgcctc ctccgtgcgc ccgccagcct cgcccgcgcc gtcacc                    1426


<210>  58
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  58
atgggagtga ggcacccgcc ctgctcccac cggctcctgg ccgtctgcgc cctcgtgtcc       60

ttggcaaccg ctgcactcct ggggcacatc ctactccatg atttcctgct ggttccccga      120

gagctgagtg gctcctcccc agtcctggag gagactcacc cagctcacca gcagggagcc      180

agcagaccag ggccccggga tgcccaggca caccccggcc gtcccagagc agtgcccaca      240

cagtgcgacg tcccccccaa cagccgcttc gattgcgccc ctgacaaggc catcacccag      300

gaacagtgcg aggcccgcgg ctgttgctac atccctgcaa agcaggggct gcagggagcc      360

cagatggggc agccctggtg cttcttccca cccagctacc ccagctacaa gctggagaac      420

ctgagctcct ctgaaatggg ctacacggcc accctgaccc gtaccacccc caccttcttc      480

cccaaggaca tcctgaccct gcggctggac gtgatgatgg agactgagaa ccgcctccac      540

ttcacgatca aagatccagc taacaggcgc tacgaggtgc ccttggagac cccgcatgtc      600

cacagccggg caccgtcccc actctacagc gtggagttct ccgaggagcc cttcggggtg      660

atcgtgcgcc ggcagctgga cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc      720

tttgcggacc agttccttca gctgtccacc tcgctgccct cgcagtatat cacaggcctc      780

gccgagcacc tcagtcccct gatgctcagc accagctgga ccaggatcac cctgtggaac      840

cgggaccttg cgcccacgcc cggtgcgaac ctctacgggt ctcacccttt ctacctggcg      900

ctggaggacg gcgggtcggc acacggggtg ttcctgctaa acagcaatgc catggatgtg      960

gtcctgcagc cgagccctgc ccttagctgg aggtcgacag gtgggatcct ggatgtctac     1020

atcttcctgg gcccagagcc caagagcgtg gtgcagcagt acctggacgt tgtgggatac     1080

ccgttcatgc cgccatactg gggcctgggc ttccacctgt gccgctgggg ctactcctcc     1140

accgctatca cccgccaggt ggtggagaac atgaccaggg cccacttccc cctggacgtc     1200

cagtggaacg acctggacta catggactcc cggagggact tcacgttcaa caaggatggc     1260

ttccgggact tcccggccat ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg     1320

atcgtggatc ctgccatcag cagctcgggc cctgccggga gctacaggcc ctacgacgag     1380

ggtctgcgga ggggggtttt catcaccaac gagaccggcc agccgctgat tgggaaggta     1440

tggcccgggt ccactgcctt ccccgacttc accaacccca cagccctggc ctggtgggag     1500

gacatggtgg ctgagttcca tgaccaggtg cccttcgacg gcatgtggat tgacatgaac     1560

gagccttcca acttcatcag gggctctgag gacggctgcc ccaacaatga gctggagaac     1620

ccaccctacg tgcctggggt ggttgggggg accctccagg cggccaccat ctgtgcctcc     1680

agccaccagt ttctctccac acactacaac ctgcacaacc tctacggcct gaccgaagcc     1740

atcgcctccc acagggcgct ggtgaaggct cgggggacac gcccatttgt gatctcccgc     1800

tcgacctttg ctggccacgg ccgatacgcc ggccactgga cgggggacgt gtggagctcc     1860

tgggagcagc tcgcctcctc cgtgccagaa atcctgcagt ttaacctgct gggggtgcct     1920

ctggtcgggg ccgacgtctg cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc     1980

tggacccagc tgggggcctt ctaccccttc atgcggaacc acaacagcct gctcagtctg     2040

ccccaggagc cgtacagctt cagcgagccg gcccagcagg ccatgaggaa ggccctcacc     2100

ctgcgctacg cactcctccc ccacctctac acactgttcc accaggccca cgtcgcgggg     2160

gagaccgtgg cccggcccct cttcctggag ttccccaagg actctagcac ctggactgtg     2220

gaccaccagc tcctgtgggg ggaggccctg ctcatcaccc cagtgctcca ggccgggaag     2280

gccgaagtga ctggctactt ccccttgggc acatggtacg acctgcagac ggtgccagta     2340

gaggcccttg gcagcctccc acccccacct gcagctcccc gtgagccagc catccacagc     2400

gaggggcagt gggtgacgct gccggccccc ctggacacca tcaacgtcca cctccgggct     2460

gggtacatca tccccctgca gggccctggc ctcacaacca cagagtcccg ccagcagccc     2520

atggccctgg ctgtggccct gaccaagggt ggggaggccc gaggggagct gttctgggac     2580

gatggagaga gcctggaagt gctggagcga ggggcctaca cacaggtcat cttcctggcc     2640

aggaataaca cgatcgtgaa tgagctggta cgtgtgacca gtgagggagc tggcctgcag     2700

ctgcagaagg tgactgtcct gggcgtggcc acggcgcccc agcaggtcct ctccaacggt     2760

gtccctgtct ccaacttcac ctacagcccc gacaccaagg tcctggacat ctgtgtctcg     2820

ctgttgatgg gagagcagtt tctcgtcagc tggtgttag                            2859


<210>  59
<211>  2859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon-optimized human acid alpha-glucosidase gene (hGAAco)

<400>  59
atgggcgtca gacatcctcc atgttctcac agactgctgg ccgtgtgtgc tctggtgtct       60

cttgctacag ctgccctgct gggacatatc ctgctgcacg attttctgct ggtgcccaga      120

gagctgtctg gcagctctcc tgtgctggaa gaaacacacc ctgcacatca gcagggcgcc      180

tctagacctg gacctagaga tgctcaagcc catcctggca gacctagagc cgtgcctaca      240

cagtgtgacg tgccacctaa cagcagattc gactgcgccc ctgacaaggc catcacacaa      300

gagcagtgtg aagccagagg ctgctgctac attcctgcca aacaaggact gcagggcgct      360

cagatgggac agccttggtg cttcttccca ccatcttacc ccagctacaa gctggaaaac      420

ctgagcagca gcgagatggg ctacaccgcc acactgacca gaaccacacc tacattcttc      480

ccaaaggaca tcctgacact gcggctggac gtgatgatgg aaaccgagaa ccggctgcac      540

ttcaccatca aggaccccgc caatagaaga tacgaggtgc ccctggaaac ccctcacgtg      600

cactctagag ccccatctcc actgtacagc gtggaattca gcgaggaacc ctttggcgtg      660

atcgtgcgga gacagctgga tggcagagtg ctgctgaata ccacagtggc ccctctgttc      720

ttcgccgacc agtttctgca gctgagcaca agcctgccta gccagtatat cacaggcctg      780

gccgaacacc tgtctccact gatgctgagc accagctgga ccagaatcac cctgtggaac      840

agagatctgg cccctacacc tggcgccaat ctgtacggct ctcacccttt ttatctggcc      900

ctggaagatg gcggaagcgc ccacggtgtc tttctgctga acagcaacgc catggacgtg      960

gtgctgcaac catctcctgc tctgtcttgg agaagcaccg gcggcatcct ggacgtgtac     1020

atctttctgg gacccgagcc taagagcgtg gtgcagcagt atctggatgt cgtgggctac     1080

cccttcatgc ctccttattg gggcctgggc ttccacctgt gtagatgggg atacagctcc     1140

accgccatca ccagacaggt ggtggaaaac atgacccggg ctcacttccc actggatgtg     1200

cagtggaacg acctggacta catggactcc agacgggact tcacctttaa caaggacggc     1260

ttcagagact tccccgccat ggtgcaagaa ctgcatcaag gcggcagacg gtacatgatg     1320

atcgtggatc ctgccatctc ttctagcggc cctgccggaa gctacagacc ttatgatgag     1380

ggcctgagaa gaggcgtgtt catcaccaat gagacaggcc agcctctgat cggcaaagtg     1440

tggcctggaa gcaccgcctt tccagacttc accaatccaa ccgctctggc ttggtgggaa     1500

gatatggtgg ccgagttcca cgatcaggtg cccttcgatg gcatgtggat cgacatgaac     1560

gagcccagca acttcatcag gggcagcgag gatggctgcc ccaacaacga actggaaaat     1620

cctccttacg tgccaggcgt tgtcggagga acactgcagg ccgccacaat ttgtgccagc     1680

agccatcagt ttctgagcac ccactacaac ctgcacaacc tgtacggcct gaccgaggcc     1740

attgcctctc atagagccct ggttaaggcc agaggcaccc ggccttttgt gatcagcaga     1800

agcacatttg ccggccacgg cagatatgcc ggacattgga caggggacgt ttggtctagt     1860

tgggagcagc tggcctctag cgtgcccgag atcctgcagt ttaatctgct gggagtgccc     1920

ctcgtgggag ccgatgtttg tggatttctg ggcaacacct ccgaggaact gtgcgtcaga     1980

tggacacagc tgggcgcctt ctatcccttc atgagaaacc acaacagcct gctgagcctg     2040

cctcaagagc cttacagctt tagcgaaccc gcacagcagg ccatgagaaa ggccctgact     2100

ctgagatacg ctctgctgcc ccacctgtac accctgtttc atcaagctca tgtggccggc     2160

gagacagtgg ccagaccact gtttctggaa ttccccaagg acagcagcac ctggacagtg     2220

gatcatcagc tgctctgggg agaagccctg ctcattacac ctgtgctgca ggctggcaag     2280

gccgaagtga caggatactt tcccctcggc acttggtacg acctgcagac agttcctgtg     2340

gaagctctgg gatctctgcc tccacctcct gctgctccta gagagcctgc cattcactct     2400

gaaggccagt gggttacact gcccgctcca ctggacacca tcaatgtgca cctgagagcc     2460

ggctacatca tccctctgca aggccctgga ctgaccacaa ccgaaagcag acagcagcca     2520

atggctctgg ccgtggctct gacaaaaggc ggagaagcta gaggcgaact gttctgggat     2580

gacggcgaga gcctggaagt gctggaacgg ggagcctaca cacaagtgat ctttctcgcc     2640

cggaacaaca ccatcgtgaa cgaactcgtc agagtgacca gtgaaggtgc cggactgcag     2700

ctccagaaag tgacagtgct tggagtggcc acagcacccc agcaggtttt gtctaatggc     2760

gtgcccgtgt ccaacttcac atacagccct gacaccaagg tgctggacat ctgtgtgtct     2820

ctgctgatgg gcgagcagtt cctggtgtcc tggtgttga                            2859


