               SEQUENCE LISTING

<110> LeadXpro AG

<120> PRO-MACROBODIES For the Enhancement of Structure Research

<130> P5859PC00

<150>  EP20157617.0
<151>  2020-02-17

<160> 12

<170> BiSSAP 1.3.6

<210> 1
<211> 485
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chimeric fusion polypeptide of a VHH antigen binding domain
      (clone L21) and MBP with the di proline linker (Pro-Macrobody 21)

<400> 1
Gly Pro Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val 
            20                  25                  30          
Lys Tyr Glu His Met Tyr Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Trp Val Ala Ala Ile Asn Ser Ala Gly Asn Glu Thr His Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Asn Val Lys Asp Ile Gly Trp Trp Ala Ala Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Pro Pro Leu Val Ile Trp Ile 
        115                 120                 125             
Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe 
    130                 135                 140                 
Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu 
145                 150                 155                 160 
Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile 
                165                 170                 175     
Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu 
            180                 185                 190         
Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro 
        195                 200                 205             
Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro 
    210                 215                 220                 
Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro 
225                 230                 235                 240 
Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu 
                245                 250                 255     
Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr 
            260                 265                 270         
Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr 
        275                 280                 285             
Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly 
    290                 295                 300                 
Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His 
305                 310                 315                 320 
Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys 
                325                 330                 335     
Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile 
            340                 345                 350         
Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys 
        355                 360                 365             
Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn 
    370                 375                 380                 
Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr 
385                 390                 395                 400 
Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu 
                405                 410                 415     
Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro 
            420                 425                 430         
Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro 
        435                 440                 445             
Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val 
    450                 455                 460                 
Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp 
465                 470                 475                 480 
Ala Gln Thr Pro Gly 
                485 

<210> 2
<211> 491
<212> PRT
<213> Artificial Sequence


<220> 
<223> Chimeric fusion polypeptide of a VHH antigen binding domain
      (clone L51) and MBP with the di proline linker (Pro-Macrobody 51)

<400> 2
Gly Pro Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln 
1               5                   10                  15      
Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser 
            20                  25                  30          
Ser Ile Thr Tyr Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Gly Val Ala Ala Leu Ala Thr Tyr Tyr Gly His Thr Tyr Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Val Ser Leu Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Ala Ala Ala Tyr Ser Gly Ile Trp Thr Pro Leu Gly Val 
            100                 105                 110         
Trp Ala Thr Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Pro 
        115                 120                 125             
Pro Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala 
    130                 135                 140                 
Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val 
145                 150                 155                 160 
Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr 
                165                 170                 175     
Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly 
            180                 185                 190         
Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe 
        195                 200                 205             
Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly 
    210                 215                 220                 
Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr 
225                 230                 235                 240 
Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro 
                245                 250                 255     
Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe 
            260                 265                 270         
Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly 
        275                 280                 285             
Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val 
    290                 295                 300                 
Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp 
305                 310                 315                 320 
Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala 
                325                 330                 335     
Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro 
            340                 345                 350         
Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr 
        355                 360                 365             
Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val 
    370                 375                 380                 
Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys 
385                 390                 395                 400 
Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val 
                405                 410                 415     
Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu 
            420                 425                 430         
Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln 
        435                 440                 445             
Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr 
    450                 455                 460                 
Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val 
465                 470                 475                 480 
Asp Glu Ala Leu Lys Asp Ala Gln Thr Pro Gly 
                485                 490     

<210> 3
<211> 126
<212> PRT
<213> Vicugna pacos


<220> 
<223> E02_12652

<400> 3
Gln Arg Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ser Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Glu Asp Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Gln Glu Gly Val 
        35                  40                  45              
Ser Cys Leu Ser Gly Arg Asp Gly Glu Val Tyr Asn Ala Glu Ser Val 
    50                  55                  60                  
Met Gly Arg Phe Thr Val Ser Lys Asp Ser Ala Lys Ser Thr Ile Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ala Asp Lys Asp Val Thr Gly Arg Gly Met Cys Thr Ile Pro Tyr 
            100                 105                 110         
Ser Asp Tyr Arg Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125     

<210> 4
<211> 124
<212> PRT
<213> Vicugna pacos


<220> 
<223> D05_12648

<400> 4
Gln Trp Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ser Gly Met Thr Asp Ile 
            20                  25                  30          
Tyr Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
        35                  40                  45              
Val Ala Trp Ile Thr Ser Gly Gly Thr Thr His His Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      
Asn Lys Val Arg Asp Phe Ser Asp Phe Pro His Trp Gly Phe Met Glu 
            100                 105                 110         
His Trp Ser Lys Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 

<210> 5
<211> 121
<212> PRT
<213> Vicugna pacos


<220> 
<223> A11_12648

<400> 5
Gln Trp Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Phe Ser Arg Gly Leu Phe Asn Asn Tyr 
            20                  25                  30          
Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Gln Ile Ser Ala Gly Gly Ala Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Met Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Leu Cys 
                85                  90                  95      
Asn Thr Gln Arg Tyr Phe Thr Ser Ala Glu Ala Arg Gly Ser Trp Gly 
            100                 105                 110         
Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     

<210> 6
<211> 113
<212> PRT
<213> Vicugna pacos


<220> 
<223> F10_12652

<400> 6
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Ile Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              
Ser Ser Ile Gly Asn Ser Asn Asp Arg Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Gln Phe Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Gly Val Pro Ala Lys Tyr Trp Gly Lys Gly Thr Pro Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 7
<211> 118
<212> PRT
<213> Vicugna pacos


<220> 
<223> A09_12649

<400> 7
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          
His Met Gly Trp Tyr Leu Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ala Ser Ile Ser Ser Tyr Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Ser Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Arg Arg Glu Gly Phe Pro Pro Gly Arg Tyr Trp Gly Lys Gly Thr 
            100                 105                 110         
Pro Val Thr Val Ser Ser 
        115             

<210> 8
<211> 120
<212> PRT
<213> Vicugna pacos


<220> 
<223> H01_12651

<400> 8
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Tyr Phe Asn 
            20                  25                  30          
Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Ala Ile Thr Ser Gly Asp Ser Thr Asn Tyr Ala Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Lys Glu Lys Gly Trp Ser Phe Ser Leu Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Pro Val Thr Val Ser Ser 
        115                 120 

<210> 9
<211> 396
<212> PRT
<213> Escherichia coli


<220> 
<223> P0AEX9|MALE_ECOLI

<400> 9
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      
Thr Met Met Phe Ser Ala Ser Ala Leu Ala Lys Ile Glu Glu Gly Lys 
            20                  25                  30          
Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu 
        35                  40                  45              
Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu 
    50                  55                  60                  
His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly 
65                  70                  75                  80  
Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr 
                85                  90                  95      
Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln 
            100                 105                 110         
Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys 
        115                 120                 125             
Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn 
    130                 135                 140                 
Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala 
145                 150                 155                 160 
Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn 
                165                 170                 175     
Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly 
            180                 185                 190         
Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly 
        195                 200                 205             
Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu 
    210                 215                 220                 
Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu 
225                 230                 235                 240 
Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp 
                245                 250                 255     
Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val 
            260                 265                 270         
Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu 
        275                 280                 285             
Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu 
    290                 295                 300                 
Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn 
305                 310                 315                 320 
Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu 
                325                 330                 335     
Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys 
            340                 345                 350         
Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala 
        355                 360                 365             
Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp 
    370                 375                 380                 
Glu Ala Leu Lys Asp Ala Gln Thr Arg Ile Thr Lys 
385                 390                 395     

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-terminus of ABD - peptide linker - C terminus of PPS

<400> 10
Val Thr Val Pro Pro Leu Val Ile 
1               5                              
 

<210> 11
<211> 364
<212> PRT
<213> Artificial Sequence


<220> 
<223> Di Proline Linker and MBP 

<400> 11
Pro Pro Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu 
1               5                   10                  15      
Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr 
            20                  25                  30          
Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala 
        35                  40                  45              
Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly 
    50                  55                  60                  
Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala 
65                  70                  75                  80  
Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn 
                85                  90                  95      
Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile 
            100                 105                 110         
Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile 
        115                 120                 125             
Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met 
    130                 135                 140                 
Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp 
145                 150                 155                 160 
Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp 
                165                 170                 175     
Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val 
            180                 185                 190         
Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile 
        195                 200                 205             
Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly 
    210                 215                 220                 
Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val 
225                 230                 235                 240 
Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly 
                245                 250                 255     
Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala 
            260                 265                 270         
Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala 
        275                 280                 285             
Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu 
    290                 295                 300                 
Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala 
305                 310                 315                 320 
Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp 
                325                 330                 335     
Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr 
            340                 345                 350         
Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Pro Gly 
        355                 360                 

<210> 12
<211> 367
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-terminus ABD-PP-MBP

<400> 12
Val Thr Val Pro Pro Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr 
1               5                   10                  15      
Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile 
            20                  25                  30          
Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln 
        35                  40                  45              
Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp 
    50                  55                  60                  
Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro 
65                  70                  75                  80  
Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val 
                85                  90                  95      
Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu 
            100                 105                 110         
Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp 
        115                 120                 125             
Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser 
    130                 135                 140                 
Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile 
145                 150                 155                 160 
Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp 
                165                 170                 175     
Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr 
            180                 185                 190         
Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp 
        195                 200                 205             
Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr 
    210                 215                 220                 
Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn 
225                 230                 235                 240 
Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro 
                245                 250                 255     
Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys 
            260                 265                 270         
Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly 
        275                 280                 285             
Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys 
    290                 295                 300                 
Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met 
305                 310                 315                 320 
Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser 
                325                 330                 335     
Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly 
            340                 345                 350         
Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Pro Gly 
        355                 360                 365         

