               SEQUENCE LISTING

<110> Biotest AG

<120> Subcutaneous administration of Factor VIII

<130> 12045 P 6689 WO

<160> 127

<170> BiSSAP 1.3.6

<210> 1
<211> 2351
<212> PRT
<213> Homo sapiens


<220> 
<221> SIGNAL
<222> 1..19
<223> signal

<220> 
<223> wt human FVIII

<400> 1
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             
Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 
Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 
Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     
Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         
Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             
Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 
Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 
Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     
Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         
Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             
Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 
Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 
Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     
Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         
Lys Gly Lys Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala 
        995                 1000                1005            
Leu Phe Lys Val Ser Ile Ser Leu Leu Lys Thr Asn Lys Thr Ser Asn 
    1010                1015                1020                
Asn Ser Ala Thr Asn Arg Lys Thr His Ile Asp Gly Pro Ser Leu Leu 
1025                1030                1035                1040
Ile Glu Asn Ser Pro Ser Val Trp Gln Asn Ile Leu Glu Ser Asp Thr 
                1045                1050                1055    
Glu Phe Lys Lys Val Thr Pro Leu Ile His Asp Arg Met Leu Met Asp 
            1060                1065                1070        
Lys Asn Ala Thr Ala Leu Arg Leu Asn His Met Ser Asn Lys Thr Thr 
        1075                1080                1085            
Ser Ser Lys Asn Met Glu Met Val Gln Gln Lys Lys Glu Gly Pro Ile 
    1090                1095                1100                
Pro Pro Asp Ala Gln Asn Pro Asp Met Ser Phe Phe Lys Met Leu Phe 
1105                1110                1115                1120
Leu Pro Glu Ser Ala Arg Trp Ile Gln Arg Thr His Gly Lys Asn Ser 
                1125                1130                1135    
Leu Asn Ser Gly Gln Gly Pro Ser Pro Lys Gln Leu Val Ser Leu Gly 
            1140                1145                1150        
Pro Glu Lys Ser Val Glu Gly Gln Asn Phe Leu Ser Glu Lys Asn Lys 
        1155                1160                1165            
Val Val Val Gly Lys Gly Glu Phe Thr Lys Asp Val Gly Leu Lys Glu 
    1170                1175                1180                
Met Val Phe Pro Ser Ser Arg Asn Leu Phe Leu Thr Asn Leu Asp Asn 
1185                1190                1195                1200
Leu His Glu Asn Asn Thr His Asn Gln Glu Lys Lys Ile Gln Glu Glu 
                1205                1210                1215    
Ile Glu Lys Lys Glu Thr Leu Ile Gln Glu Asn Val Val Leu Pro Gln 
            1220                1225                1230        
Ile His Thr Val Thr Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu 
        1235                1240                1245            
Leu Ser Thr Arg Gln Asn Val Glu Gly Ser Tyr Asp Gly Ala Tyr Ala 
    1250                1255                1260                
Pro Val Leu Gln Asp Phe Arg Ser Leu Asn Asp Ser Thr Asn Arg Thr 
1265                1270                1275                1280
Lys Lys His Thr Ala His Phe Ser Lys Lys Gly Glu Glu Glu Asn Leu 
                1285                1290                1295    
Glu Gly Leu Gly Asn Gln Thr Lys Gln Ile Val Glu Lys Tyr Ala Cys 
            1300                1305                1310        
Thr Thr Arg Ile Ser Pro Asn Thr Ser Gln Gln Asn Phe Val Thr Gln 
        1315                1320                1325            
Arg Ser Lys Arg Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr 
    1330                1335                1340                
Glu Leu Glu Lys Arg Ile Ile Val Asp Asp Thr Ser Thr Gln Trp Ser 
1345                1350                1355                1360
Lys Asn Met Lys His Leu Thr Pro Ser Thr Leu Thr Gln Ile Asp Tyr 
                1365                1370                1375    
Asn Glu Lys Glu Lys Gly Ala Ile Thr Gln Ser Pro Leu Ser Asp Cys 
            1380                1385                1390        
Leu Thr Arg Ser His Ser Ile Pro Gln Ala Asn Arg Ser Pro Leu Pro 
        1395                1400                1405            
Ile Ala Lys Val Ser Ser Phe Pro Ser Ile Arg Pro Ile Tyr Leu Thr 
    1410                1415                1420                
Arg Val Leu Phe Gln Asp Asn Ser Ser His Leu Pro Ala Ala Ser Tyr 
1425                1430                1435                1440
Arg Lys Lys Asp Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly 
                1445                1450                1455    
Ala Lys Lys Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Thr 
            1460                1465                1470        
Gly Asp Gln Arg Glu Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser 
        1475                1480                1485            
Val Thr Tyr Lys Lys Val Glu Asn Thr Val Leu Pro Lys Pro Asp Leu 
    1490                1495                1500                
Pro Lys Thr Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile Tyr 
1505                1510                1515                1520
Gln Lys Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His 
                1525                1530                1535    
Leu Asp Leu Val Glu Gly Ser Leu Leu Gln Gly Thr Glu Gly Ala Ile 
            1540                1545                1550        
Lys Trp Asn Glu Ala Asn Arg Pro Gly Lys Val Pro Phe Leu Arg Val 
        1555                1560                1565            
Ala Thr Glu Ser Ser Ala Lys Thr Pro Ser Lys Leu Leu Asp Pro Leu 
    1570                1575                1580                
Ala Trp Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys 
1585                1590                1595                1600
Ser Gln Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr 
                1605                1610                1615    
Ile Leu Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile 
            1620                1625                1630        
Asn Glu Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln 
        1635                1640                1645            
Gly Arg Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg 
    1650                1655                1660                
His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu 
1665                1670                1675                1680
Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe 
                1685                1690                1695    
Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys 
            1700                1705                1710        
Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr 
        1715                1720                1725            
Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly 
    1730                1735                1740                
Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly 
1745                1750                1755                1760
Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly 
                1765                1770                1775    
Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val 
            1780                1785                1790        
Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu 
        1795                1800                1805            
Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn 
    1810                1815                1820                
Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His 
1825                1830                1835                1840
His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr 
                1845                1850                1855    
Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly 
            1860                1865                1870        
Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg 
        1875                1880                1885            
Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu 
    1890                1895                1900                
Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala 
1905                1910                1915                1920
Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg 
                1925                1930                1935    
Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val 
            1940                1945                1950        
Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser 
        1955                1960                1965            
Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val 
    1970                1975                1980                
Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly 
1985                1990                1995                2000
Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg 
                2005                2010                2015    
Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu 
            2020                2025                2030        
Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser 
        2035                2040                2045            
Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln 
    2050                2055                2060                
Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala 
2065                2070                2075                2080
Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala 
                2085                2090                2095    
Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe 
            2100                2105                2110        
Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly 
        2115                2120                2125            
Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val 
    2130                2135                2140                
Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn 
2145                2150                2155                2160
Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser 
                2165                2170                2175    
Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser 
            2180                2185                2190        
Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln 
        2195                2200                2205            
Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro 
    2210                2215                2220                
Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro 
2225                2230                2235                2240
Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr 
                2245                2250                2255    
Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr 
            2260                2265                2270        
Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His 
        2275                2280                2285            
Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly 
    2290                2295                2300                
Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu 
2305                2310                2315                2320
Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile 
                2325                2330                2335    
Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
            2340                2345                2350    

<210> 2
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> minimal processing sequence

<400> 2
Pro Arg Ser Phe Ser Gln Asn Pro Pro 
1               5                   

<210> 3
<400> 3
000

<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Processing sequence

<400> 4
Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
1               5                   10      

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Processing sequence

<220> 
<221> VARIANT
<222> 4
<223> can be varied for de-immunization

<400> 5
Pro Arg Ser Xaa Ser Gln Asn Pro Pro Val Leu 
1               5                   10      

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Processing sequence

<220> 
<221> VARIANT
<222> 5
<223> can be varied for de-immunization

<400> 6
Pro Arg Ser Phe Xaa Gln Asn Pro Pro Val Leu 
1               5                   10      

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Processing sequence

<220> 
<221> VARIANT
<222> 6
<223> can be varied for de-immunization

<400> 7
Pro Arg Ser Phe Ser Xaa Asn Pro Pro Val Leu 
1               5                   10      

<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Processing sequence

<220> 
<221> VARIANT
<222> 7
<223> can be varied for de-immunization

<400> 8
Pro Arg Ser Phe Ser Gln Xaa Pro Pro Val Leu 
1               5                   10      

<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Merging sequence, e.g., in V0

<400> 9
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp 
1               5                   10  

<210> 10
<400> 10
000

<210> 11
<400> 11
000

<210> 12
<400> 12
000

<210> 13
<400> 13
000

<210> 14
<400> 14
000

<210> 15
<400> 15
000

<210> 16
<211> 1445
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> V0 aa incl. signal sequence

<400> 16
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
    770                 775                 780                 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
785                 790                 795                 800 
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
                805                 810                 815     
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
            820                 825                 830         
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
        835                 840                 845             
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
    850                 855                 860                 
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
865                 870                 875                 880 
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
                885                 890                 895     
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
            900                 905                 910         
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
        915                 920                 925             
Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
    930                 935                 940                 
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
945                 950                 955                 960 
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
                965                 970                 975     
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
            980                 985                 990         
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
        995                 1000                1005            
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
    1010                1015                1020                
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
1025                1030                1035                1040
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
                1045                1050                1055    
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
            1060                1065                1070        
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
        1075                1080                1085            
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
    1090                1095                1100                
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
1105                1110                1115                1120
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr 
                1125                1130                1135    
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
            1140                1145                1150        
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
        1155                1160                1165            
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
    1170                1175                1180                
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
1185                1190                1195                1200
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
                1205                1210                1215    
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
            1220                1225                1230        
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
        1235                1240                1245            
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
    1250                1255                1260                
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
1265                1270                1275                1280
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
                1285                1290                1295    
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
            1300                1305                1310        
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
        1315                1320                1325            
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
    1330                1335                1340                
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
1345                1350                1355                1360
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
                1365                1370                1375    
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
            1380                1385                1390        
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
        1395                1400                1405            
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
    1410                1415                1420                
Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
1425                1430                1435                1440
Ala Gln Asp Leu Tyr 
                1445

<210> 17
<400> 17
000

<210> 18
<400> 18
000

<210> 19
<400> 19
000

<210> 20
<400> 20
000

<210> 21
<400> 21
000

<210> 22
<400> 22
000

<210> 23
<400> 23
000

<210> 24
<400> 24
000

<210> 25
<400> 25
000

<210> 26
<400> 26
000

<210> 27
<400> 27
000

<210> 28
<211> 1457
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> AC-6rs-REF aa incl. signal

<400> 28
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 
Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 
Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     
Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         
Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 
Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 
Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         
Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             
Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 
Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 
Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     
Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         
Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 
        995                 1000                1005            
Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys 
    1010                1015                1020                
Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn 
1025                1030                1035                1040
Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly 
                1045                1050                1055    
Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met 
            1060                1065                1070        
Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe 
        1075                1080                1085            
Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 
    1090                1095                1100                
Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile 
1105                1110                1115                1120
Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser 
                1125                1130                1135    
Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met 
            1140                1145                1150        
Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr 
        1155                1160                1165            
Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile 
    1170                1175                1180                
Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu 
1185                1190                1195                1200
Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln 
                1205                1210                1215    
Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu 
            1220                1225                1230        
Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 
        1235                1240                1245            
Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile 
    1250                1255                1260                
Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 
1265                1270                1275                1280
Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu 
                1285                1290                1295    
Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp 
            1300                1305                1310        
Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp 
        1315                1320                1325            
Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 
    1330                1335                1340                
Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln 
1345                1350                1355                1360
Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu 
                1365                1370                1375    
Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp 
            1380                1385                1390        
Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe 
        1395                1400                1405            
Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro 
    1410                1415                1420                
Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His 
1425                1430                1435                1440
Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 
                1445                1450                1455    
Tyr 
    

<210> 29
<400> 29
000

<210> 30
<400> 30
000

<210> 31
<400> 31
000

<210> 32
<400> 32
000

<210> 33
<400> 33
000

<210> 34
<400> 34
000

<210> 35
<400> 35
000

<210> 36
<400> 36
000

<210> 37
<400> 37
000

<210> 38
<400> 38
000

<210> 39
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Thrombin-cleavable linker

<400> 39
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
1               5                   10                  15      
His Pro Ser 
            

<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> glycine-serine linker G1

<220> 
<221> VARIANT
<222> 14
<223> G in position 14 is present or absent

<400> 40
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  

<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> glycine-serine linker G2

<400> 41
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          

<210> 42
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLG-1 linker

<400> 42
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Lys 
1               5                   10                  15      
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
            20                  25                  30          
Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser 
        35                  40                  45      

<210> 43
<211> 43
<212> PRT
<213> Artificial Sequence


<220> 
<223> GLG-2 linker

<400> 43
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Lys Asn Asn 
1               5                   10                  15      
Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Gly 
            20                  25                  30          
Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40              

<210> 44
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABD consensus sequence

<220> 
<221> VARIANT
<222> 3
<223> X3 is selected from E, S, Q and C

<220> 
<221> VARIANT
<222> 6
<223> X6 is selected from E, S, C and V

<220> 
<221> VARIANT
<222> 7
<223> X7 is selected from A, S and L

<220> 
<221> VARIANT
<222> 10
<223> X10 is selected from A, S and R

<220> 
<221> VARIANT
<222> 14
<223> X14 is selected from A, S, C and K

<220> 
<221> VARIANT
<222> 26
<223> X26 is selected from D, E and N

<220> 
<221> VARIANT
<222> 39
<223> X39 is selected from D, E and L

<220> 
<221> VARIANT
<222> 40
<223> X40 is selected from A, E and H

<220> 
<221> VARIANT
<222> 43
<223> X43 is selected from A and K

<220> 
<221> VARIANT
<222> 44
<223> X44 is selected from A, S and E

<220> 
<221> VARIANT
<222> 45
<223> L in position 45 is present or absent

<220> 
<221> VARIANT
<222> 46
<223> P in position 46 is present or absent

<400> 44
Leu Ala Xaa Ala Lys Xaa Xaa Ala Asn Xaa Glu Leu Asp Xaa Tyr Gly 
1               5                   10                  15      
Val Ser Asp Phe Tyr Lys Arg Leu Ile Xaa Lys Ala Lys Thr Val Glu 
            20                  25                  30          
Gly Val Glu Ala Leu Lys Xaa Xaa Ile Leu Xaa Xaa Leu Pro 
        35                  40                  45      

<210> 45
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABD1

<400> 45
Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      
Val Ser Asp Phe Tyr Lys Arg Leu Ile Asn Lys Ala Lys Thr Val Glu 
            20                  25                  30          
Gly Val Glu Ala Leu Lys Leu His Ile Leu Ala Ala Leu Pro 
        35                  40                  45      

<210> 46
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<223> ABD2

<400> 46
Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
1               5                   10                  15      
Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
            20                  25                  30          
Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
        35                  40                  45      

<210> 47
<211> 1575
<212> PRT
<213> Artificial Sequence


<220> 
<223> ADLCLD_SC aa

<400> 47
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
    770                 775                 780                 
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
785                 790                 795                 800 
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
                805                 810                 815     
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
            820                 825                 830         
Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val 
        835                 840                 845             
Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln 
    850                 855                 860                 
Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala 
865                 870                 875                 880 
Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu 
                885                 890                 895     
Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val 
            900                 905                 910         
Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly 
        915                 920                 925             
Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu 
    930                 935                 940                 
Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro 
945                 950                 955                 960 
Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln 
                965                 970                 975     
Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr 
            980                 985                 990         
Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe 
        995                 1000                1005            
Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp 
    1010                1015                1020                
Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr 
1025                1030                1035                1040
Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 
                1045                1050                1055    
Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn 
            1060                1065                1070        
Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro 
        1075                1080                1085            
Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met 
    1090                1095                1100                
Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp 
1105                1110                1115                1120
Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 
                1125                1130                1135    
Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala 
            1140                1145                1150        
Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro 
        1155                1160                1165            
Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu 
    1170                1175                1180                
His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln 
1185                1190                1195                1200
Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr 
                1205                1210                1215    
Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His 
            1220                1225                1230        
Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp 
        1235                1240                1245            
Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr 
    1250                1255                1260                
Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile 
1265                1270                1275                1280
Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 
                1285                1290                1295    
Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly 
            1300                1305                1310        
Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg 
        1315                1320                1325            
Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu 
    1330                1335                1340                
Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser 
1345                1350                1355                1360
Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 
                1365                1370                1375    
Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly 
            1380                1385                1390        
Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu 
        1395                1400                1405            
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln 
    1410                1415                1420                
Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 
1425                1430                1435                1440
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly 
                1445                1450                1455    
Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 
            1460                1465                1470        
Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro 
        1475                1480                1485            
Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
    1490                1495                1500                
Glu Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser 
1505                1510                1515                1520
Phe Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala 
                1525                1530                1535    
Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg 
            1540                1545                1550        
Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp 
        1555                1560                1565            
Ala Ile Leu Ala Ala Leu Pro 
    1570                1575

<210> 48
<211> 1778
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD2_SC aa

<400> 48
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser 
        835                 840                 845             
Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
    850                 855                 860                 
Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu 
865                 870                 875                 880 
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                885                 890                 895     
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            900                 905                 910         
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
        915                 920                 925             
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
    930                 935                 940                 
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
945                 950                 955                 960 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
                965                 970                 975     
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
            980                 985                 990         
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
        995                 1000                1005            
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
    1010                1015                1020                
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
1025                1030                1035                1040
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
                1045                1050                1055    
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
            1060                1065                1070        
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
        1075                1080                1085            
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
    1090                1095                1100                
Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
1105                1110                1115                1120
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
                1125                1130                1135    
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
            1140                1145                1150        
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
        1155                1160                1165            
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
    1170                1175                1180                
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1185                1190                1195                1200
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
                1205                1210                1215    
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
            1220                1225                1230        
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
        1235                1240                1245            
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
    1250                1255                1260                
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
1265                1270                1275                1280
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
                1285                1290                1295    
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr 
            1300                1305                1310        
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
        1315                1320                1325            
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
    1330                1335                1340                
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
1345                1350                1355                1360
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
                1365                1370                1375    
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
            1380                1385                1390        
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
        1395                1400                1405            
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
    1410                1415                1420                
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1425                1430                1435                1440
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
                1445                1450                1455    
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
            1460                1465                1470        
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
        1475                1480                1485            
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
    1490                1495                1500                
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
1505                1510                1515                1520
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
                1525                1530                1535    
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
            1540                1545                1550        
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
        1555                1560                1565            
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
    1570                1575                1580                
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
1585                1590                1595                1600
Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
                1605                1610                1615    
Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
            1620                1625                1630        
Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        1635                1640                1645            
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    1650                1655                1660                
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
1665                1670                1675                1680
Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                1685                1690                1695    
Ser Gly Ser Gly Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
            1700                1705                1710        
Gln Asn Ser Arg His Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        1715                1720                1725            
Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu 
    1730                1735                1740                
Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala 
1745                1750                1755                1760
Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala 
                1765                1770                1775    
Leu Pro 
        

<210> 49
<211> 1694
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD2woL_SC aa

<400> 49
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu Ala Glu 
    770                 775                 780                 
Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp 
785                 790                 795                 800 
Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu 
                805                 810                 815     
Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser 
            820                 825                 830         
Gly Gly Ser Gly Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        835                 840                 845             
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    850                 855                 860                 
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
865                 870                 875                 880 
Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                885                 890                 895     
Ser Gly Ser Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile 
            900                 905                 910         
Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu 
        915                 920                 925             
Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile 
    930                 935                 940                 
Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His 
945                 950                 955                 960 
Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys 
                965                 970                 975     
Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr 
            980                 985                 990         
Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg 
        995                 1000                1005            
Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser 
    1010                1015                1020                
Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln 
1025                1030                1035                1040
Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr 
                1045                1050                1055    
Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp 
            1060                1065                1070        
Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu 
        1075                1080                1085            
Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr 
    1090                1095                1100                
Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe 
1105                1110                1115                1120
Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr 
                1125                1130                1135    
Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu 
            1140                1145                1150        
Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr 
        1155                1160                1165            
Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile 
    1170                1175                1180                
Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile 
1185                1190                1195                1200
His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys 
                1205                1210                1215    
Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met 
            1220                1225                1230        
Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu 
        1235                1240                1245            
His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys 
    1250                1255                1260                
Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln 
1265                1270                1275                1280
Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg 
                1285                1290                1295    
Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe 
            1300                1305                1310        
Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile 
        1315                1320                1325            
Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln 
    1330                1335                1340                
Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg 
1345                1350                1355                1360
Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser 
                1365                1370                1375    
Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr 
            1380                1385                1390        
Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met 
        1395                1400                1405            
Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met 
    1410                1415                1420                
Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe 
1425                1430                1435                1440
Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu 
                1445                1450                1455    
Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu 
            1460                1465                1470        
Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr 
        1475                1480                1485            
Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe 
    1490                1495                1500                
Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln 
1505                1510                1515                1520
Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro 
                1525                1530                1535    
Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile 
            1540                1545                1550        
His Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 
        1555                1560                1565            
Gly Cys Glu Ala Gln Asp Leu Tyr Gly Ser Gly Gly Ser Gly Gly Ser 
    1570                1575                1580                
Gly Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu 
1585                1590                1595                1600
Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys 
                1605                1610                1615    
Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala 
            1620                1625                1630        
Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser 
        1635                1640                1645            
Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
    1650                1655                1660                
Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
1665                1670                1675                1680
Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
                1685                1690                

<210> 50
<211> 1629
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD2woLG_SC aa

<400> 50
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
    770                 775                 780                 
Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
785                 790                 795                 800 
Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Leu Ala 
                805                 810                 815     
Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser 
            820                 825                 830         
Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val 
        835                 840                 845             
Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Gln Ser Asp Gln 
    850                 855                 860                 
Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
865                 870                 875                 880 
Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                885                 890                 895     
Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            900                 905                 910         
Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        915                 920                 925             
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    930                 935                 940                 
Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
945                 950                 955                 960 
Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                965                 970                 975     
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            980                 985                 990         
Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        995                 1000                1005            
Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    1010                1015                1020                
Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
1025                1030                1035                1040
Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                1045                1050                1055    
Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            1060                1065                1070        
Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 
        1075                1080                1085            
Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys 
    1090                1095                1100                
Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn 
1105                1110                1115                1120
Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly 
                1125                1130                1135    
Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met 
            1140                1145                1150        
Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe 
        1155                1160                1165            
Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 
    1170                1175                1180                
Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile 
1185                1190                1195                1200
Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser 
                1205                1210                1215    
Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met 
            1220                1225                1230        
Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr 
        1235                1240                1245            
Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile 
    1250                1255                1260                
Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu 
1265                1270                1275                1280
Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln 
                1285                1290                1295    
Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu 
            1300                1305                1310        
Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 
        1315                1320                1325            
Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile 
    1330                1335                1340                
Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 
1345                1350                1355                1360
Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu 
                1365                1370                1375    
Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp 
            1380                1385                1390        
Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp 
        1395                1400                1405            
Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 
    1410                1415                1420                
Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln 
1425                1430                1435                1440
Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu 
                1445                1450                1455    
Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp 
            1460                1465                1470        
Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe 
        1475                1480                1485            
Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro 
    1490                1495                1500                
Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His 
1505                1510                1515                1520
Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 
                1525                1530                1535    
Tyr Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr 
            1540                1545                1550        
Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val 
        1555                1560                1565            
Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Leu 
    1570                1575                1580                
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
1585                1590                1595                1600
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
                1605                1610                1615    
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
            1620                1625                

<210> 51
<211> 1778
<212> PRT
<213> Artificial Sequence


<220> 
<223> AbD2CD2_SC aa

<400> 51
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser 
        835                 840                 845             
Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
    850                 855                 860                 
Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu 
865                 870                 875                 880 
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                885                 890                 895     
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            900                 905                 910         
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
        915                 920                 925             
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
    930                 935                 940                 
Gln Ser Asp Gln Glu Glu Ile Asp Phe Asp Asp Thr Ile Ser Val Glu 
945                 950                 955                 960 
Met Lys Lys Glu Asp Phe Asp Ile Phe Asp Glu Asp Glu Asn Gln Ser 
                965                 970                 975     
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
            980                 985                 990         
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
        995                 1000                1005            
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
    1010                1015                1020                
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
1025                1030                1035                1040
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
                1045                1050                1055    
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
            1060                1065                1070        
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
        1075                1080                1085            
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
    1090                1095                1100                
Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
1105                1110                1115                1120
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
                1125                1130                1135    
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
            1140                1145                1150        
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
        1155                1160                1165            
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
    1170                1175                1180                
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1185                1190                1195                1200
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
                1205                1210                1215    
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
            1220                1225                1230        
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
        1235                1240                1245            
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
    1250                1255                1260                
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
1265                1270                1275                1280
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
                1285                1290                1295    
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr 
            1300                1305                1310        
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
        1315                1320                1325            
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
    1330                1335                1340                
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
1345                1350                1355                1360
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
                1365                1370                1375    
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
            1380                1385                1390        
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
        1395                1400                1405            
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
    1410                1415                1420                
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1425                1430                1435                1440
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
                1445                1450                1455    
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
            1460                1465                1470        
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
        1475                1480                1485            
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
    1490                1495                1500                
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
1505                1510                1515                1520
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
                1525                1530                1535    
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
            1540                1545                1550        
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
        1555                1560                1565            
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
    1570                1575                1580                
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
1585                1590                1595                1600
Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
                1605                1610                1615    
Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
            1620                1625                1630        
Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        1635                1640                1645            
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    1650                1655                1660                
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
1665                1670                1675                1680
Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                1685                1690                1695    
Ser Gly Ser Gly Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
            1700                1705                1710        
Gln Asn Ser Arg His Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        1715                1720                1725            
Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu 
    1730                1735                1740                
Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala 
1745                1750                1755                1760
Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala 
                1765                1770                1775    
Leu Pro 
        

<210> 52
<211> 4728
<212> DNA
<213> Artificial Sequence


<220> 
<223> ADLCLD_SC na

<400> 52
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gccccggtcc     2280

ttcagccaga acccccccgt gctggccgag gccaaggagg ccgccaacgc cgagctggac     2340

agctacggcg tgagcgactt ctacaagcgc ctgatcgaca aggccaagac cgtggagggc     2400

gtggaggccc tgaaggacgc catcctggcc gccctgccca gcaaaaataa cgctatagag     2460

cccaggagct ttagtcagaa tagcaggcac ccgagtctgc agagcgacca ggaagagatc     2520

gactacgacg acaccatcag cgtcgagatg aagaaagagg acttcgacat ctacgacgag     2580

gacgagaacc agagcccccg gtccttccag aagaaaaccc ggcactactt tatcgccgcc     2640

gtggaacggc tgtgggacta cggcatgagc agcagccccc acgtgctgcg gaatagagcc     2700

cagagcggca gcgtgcccca gttcaagaaa gtggtgttcc aggagttcac cgacggcagc     2760

ttcacccagc ctctgtaccg gggcgagctg aacgagcacc tgggcctgct gggcccctac     2820

atccgggccg aggtggaaga taacatcatg gtcaccttcc ggaaccaggc cagccggccc     2880

tacagcttct acagcagcct gatctcctac gaagaggacc agcggcaggg cgccgagccc     2940

cggaagaact tcgtgaagcc caacgagaca aagacctact tctggaaggt gcagcaccac     3000

atggccccca ccaaggacga attcgactgc aaggcctggg cctacttcag cgacgtggac     3060

ctggaaaagg acgtgcacag cggcctgatc ggccccctgc tcgtgtgcca caccaacacc     3120

ctgaaccccg cccacggccg gcaggtcaca gtgcaggaat ttgccctgtt cttcaccatc     3180

ttcgacgaga caaagagctg gtacttcacc gagaacatgg aacggaactg cagagccccc     3240

tgcaacatcc agatggaaga tcccaccttc aaagagaact accggttcca cgccatcaac     3300

ggctacatca tggacaccct gcccggcctg gtcatggccc aggaccagcg gatccggtgg     3360

tatctgctga gcatgggcag caacgagaac atccacagca tccacttcag cggccacgtg     3420

ttcaccgtgc ggaagaaaga agagtacaag atggccctgt acaacctgta ccccggcgtg     3480

ttcgagacag tggaaatgct gcccagcaag gccggcatct ggcgggtgga atgtctgatc     3540

ggcgagcatc tgcacgccgg catgagcacc ctgtttctgg tgtacagcaa caagtgccag     3600

acccccctgg gcatggccag cggccacatc cgggatttcc agatcaccgc ctccggccag     3660

tacggccagt gggcccctaa actggcccgg ctgcactaca gcggcagcat caacgcctgg     3720

tccaccaaag agcccttcag ctggatcaag gtggacctgc tggcccccat gatcatccac     3780

ggcatcaaga cccagggcgc cagacagaag ttcagcagcc tgtacatcag ccagttcatc     3840

atcatgtaca gcctggacgg caagaagtgg cagacctacc ggggcaacag caccggcacc     3900

ctgatggtgt tcttcggcaa cgtggacagc agcggcatca agcacaacat cttcaacccc     3960

cccatcattg cccggtacat ccggctgcac cccacccact acagcatccg gtccaccctg     4020

cggatggaac tgatgggctg cgacctgaac agctgcagca tgcctctggg catggaaagc     4080

aaggccatca gcgacgccca gatcacagcc agcagctact tcaccaacat gttcgccacc     4140

tggtccccat ccaaggccag actgcatctg cagggcagaa gcaatgcctg gcggcctcag     4200

gtcaacaacc ccaaagagtg gctgcaggtc gacttccaga aaaccatgaa ggtcacaggc     4260

gtgaccaccc agggcgtgaa gtccctgctg acctctatgt acgtgaaaga gttcctgatc     4320

agcagcagcc aggacggcca ccagtggacc ctgttctttc agaacggcaa agtgaaggtg     4380

ttccagggca accaggacag cttcaccccc gtggtcaact ccctggaccc cccactgctg     4440

accagatacc tgcggatcca cccccagagc tgggtgcacc agatcgccct gagaatggaa     4500

gtgctgggat gcgaggccca ggatctgtac agcaagaaca acgccatcga gcccagaagc     4560

ttcagccaga acagccggca ccctagcctg gccgaggcca aagaagccgc caacgccgag     4620

ctggacagct acggcgtgtc cgacttctac aagcggctga tcgacaaggc caagaccgtg     4680

gaaggcgtgg aagccctgaa ggacgccatc ctggccgccc tgccctga                  4728


<210> 53
<211> 5337
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD2_SC na

<400> 53
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcctcggagc     2280

ttcagccaga atcctcctgt gctgtccaaa aacaatgcca ttgagccccg gtcattctcc     2340

cagaactcta gacacccaag cctggccgaa gccaaagaag ccgctaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgata aggccaagac cgtggaaggc     2460

gtggaagccc tgaaagatgc tattctggcc gctctgcctg gaagcggagg tagcggagga     2520

tctggcggtt ctggcagcgg atctaagaac aatgctatcg aaccccgctc ctttagccag     2580

aacagcagac acccttctgg aagtggtggt tctggtggat ccggcggatc tggatctctg     2640

gcagaggcta aagaggccgc caacgctgaa ctcgactcct atggggtgtc cgatttttac     2700

aaacgcctca ttgacaaggc caaaacagtc gagggcgtcg aggctctgaa ggatgccatt     2760

cttgctgccc tgccatctaa aaacaacgca atagagccca gatccttcag tcagaacagt     2820

cggcacccca gccagagcga ccaagaggaa atcgactacg acgacaccat cagcgtcgag     2880

atgaagaaag aggacttcga catctacgac gaggacgaga atcagagccc cagaagcttc     2940

cagaaaaaga cccggcacta ctttatcgcc gccgtggaaa gactgtggga ctacggaatg     3000

agcagcagcc ctcacgtgct gagaaataga gcacagagcg gcagcgtgcc ccagttcaag     3060

aaagtggtgt tccaagagtt caccgacggc agcttcaccc agcctctgta tagaggcgag     3120

ctgaatgagc acctgggcct gctgggacct tatatcagag ccgaggtgga agataacatc     3180

atggtcacct tccggaacca ggccagcaga ccctacagct tctacagcag cctgatcagc     3240

tacgaagagg accagagaca gggcgccgag cctagaaaga acttcgtgaa gcccaacgag     3300

acaaagacct acttttggaa ggtgcagcac cacatggccc ctaccaagga cgaattcgat     3360

tgcaaggcct gggcctactt cagcgacgtg gacctggaaa aggatgtgca ctctggcctg     3420

atcggccctc tgctcgtgtg tcacaccaac acactgaacc ccgctcacgg cagacaagtg     3480

accgtgcaag agttcgccct gttcttcacc atcttcgacg agacaaagag ctggtacttc     3540

accgagaaca tggaacggaa ctgcagagcc ccttgcaaca tccagatgga agatcccacc     3600

ttcaaagaga actaccggtt ccacgccatc aacggctaca tcatggatac cctgcctggc     3660

ctggttatgg cccaggacca gagaatcaga tggtatctgc tgagcatggg cagcaacgag     3720

aacatccaca gcatccactt cagcggccac gtgttcaccg tgcggaagaa agaagagtac     3780

aagatggccc tgtacaatct gtaccccggc gtgttcgaga cagtggaaat gctgccttct     3840

aaggccggca tttggagagt ggaatgtctg atcggagagc atctgcacgc cggcatgagc     3900

accctgtttc tggtgtacag caacaagtgt cagacccctc tcggcatggc ctccggccac     3960

atcagagatt ttcagatcac agccagcggc cagtatggcc agtgggctcc taaactggcc     4020

agactgcact acagcggcag catcaatgcc tggtccacca aagagccctt cagctggatt     4080

aaggtggacc tgctggcccc tatgatcatc cacggcatca aaacacaggg cgccagacag     4140

aagttcagca gcctgtacat cagccagttc atcatcatgt acagcctgga cggcaagaag     4200

tggcagacct acagaggcaa tagcaccggc acactgatgg tgttcttcgg caatgtggac     4260

agcagcggca tcaagcacaa catcttcaac cctccaatca ttgcccggta catccggctg     4320

caccccacac actacagcat ccggtctacc ctgagaatgg aactgatggg ctgcgacctg     4380

aacagctgta gcatgcccct cggaatggaa agcaaggcca tcagcgacgc ccagatcacc     4440

gcctccagct acttcaccaa catgttcgcc acttggagcc cctccaaagc cagactccat     4500

ctgcaaggca gatctaacgc ttggaggccc caagtgaaca accccaaaga gtggctgcag     4560

gtcgacttcc agaaaaccat gaaggtcaca ggcgtgacaa cccagggcgt gaagtctctg     4620

ctgacctcta tgtacgtgaa agagttcctg atcagcagca gccaggacgg ccaccagtgg     4680

accctgtttt tccagaacgg caaagtgaag gtgttccagg gcaaccagga cagcttcacc     4740

cctgtggtca atagcctgga tcctccactg ctgaccagat acctgcggat tcaccctcag     4800

agctgggtgc accagatcgc tctcagaatg gaagtgctgg gatgtgaagc ccaggatctg     4860

tactccaaga acaacgccat cgagcccaga agcttcagcc agaactctag acacccaagc     4920

ctggccgaag ccaaagaagc cgctaacgcc gagctggata gctacggcgt gtccgacttc     4980

tacaagcggc tgatcgataa ggccaagacc gtggaaggcg tggaagccct gaaagatgcc     5040

attctggctg ctctgcctgg aagcggagga agtggtggat ctggcggttc tggctccggc     5100

agcaaaaaca atgccattga gcctcggagc ttctcccaga acagcagaca tccttctgga     5160

tcaggcggta gcggaggatc cggcggatct ggatctctgg ctgaggctaa agaggccgcc     5220

aacgctgaac tcgactccta tggggtgtcc gatttttaca aacgcctcat tgacaaggcc     5280

aaaacagtcg agggcgtcga ggctctgaag gatgctattc ttgccgcact gccctga        5337


<210> 54
<211> 5085
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD2woL_SC na

<400> 54
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gccccggtcc     2280

ttcagccaga acccccccgt gctgggaagc ggaggatctg gcggctcagg cggatctgga     2340

tctctggccg aagccaaaga agccgccaac gccgagctgg acagctatgg cgtgtccgac     2400

ttctacaagc ggctgatcga caaggccaag acagtggaag gcgtggaagc tctgaaggat     2460

gccatcctgg ccgctctgcc tggaagtggg ggatcaggcg gcagcggagg aagtggaagt     2520

ctggctgagg ctaaagaggc tgctaacgct gaactggact cttacggggt gtccgatttt     2580

tacaaaagac tgattgataa ggctaaaact gtggaagggg tggaagccct gaaagacgct     2640

attctggctg ccctgcctgg ctccgggggc tctggcggaa gtggcggcag tggatctcag     2700

agcgaccagg aagagatcga ctacgacgac accatcagcg tcgagatgaa gaaagaggac     2760

ttcgacatct acgacgagga cgagaaccag agcccccggt ccttccagaa gaaaacccgg     2820

cactacttta tcgccgccgt ggaacggctg tgggactacg gcatgagcag cagcccccac     2880

gtgctgcgga atagagccca gagcggcagc gtgccccagt tcaagaaagt ggtgttccag     2940

gagttcaccg acggcagctt cacccagcct ctgtaccggg gcgagctgaa cgagcacctg     3000

ggcctgctgg gcccctacat ccgggccgag gtggaagata acatcatggt caccttccgg     3060

aaccaggcca gccggcccta cagcttctac agcagcctga tctcctacga agaggaccag     3120

cggcagggcg ccgagccccg gaagaacttc gtgaagccca acgagacaaa gacctacttc     3180

tggaaggtgc agcaccacat ggcccccacc aaggacgaat tcgactgcaa ggcctgggcc     3240

tacttcagcg acgtggacct ggaaaaggac gtgcacagcg gcctgatcgg ccccctgctc     3300

gtgtgccaca ccaacaccct gaaccccgcc cacggccggc aggtcacagt gcaggaattt     3360

gccctgttct tcaccatctt cgacgagact aagagctggt acttcaccga gaacatggaa     3420

cggaactgca gagccccctg caacatccag atggaagatc ccaccttcaa agagaactac     3480

cggttccacg ccatcaatgg ctacatcatg gacaccctgc ccggcctggt catggcccag     3540

gaccagagaa tccggtggta tctgctgagc atgggcagca acgagaacat ccacagcatc     3600

cacttcagcg gccacgtgtt caccgtgcgg aagaaagaag agtacaagat ggccctgtac     3660

aacctgtacc ccggcgtgtt cgaaacagtg gaaatgctgc ccagcaaggc cggcatctgg     3720

cgggtggaat gtctgatcgg cgagcatctg cacgccggca tgtccaccct gtttctggtg     3780

tacagcaaca agtgccagac ccccctgggc atggccagcg gccacatccg ggatttccag     3840

atcaccgcct ccggccagta cggccagtgg gcccctaaac tggcccggct gcactacagc     3900

ggcagcatca acgcctggtc caccaaagag cccttcagct ggatcaaggt ggacctgctg     3960

gcccccatga ttatccacgg catcaagaca cagggcgcca gacagaagtt cagcagcctg     4020

tacatcagcc agttcatcat catgtacagc ctggatggca agaagtggca gacctaccgg     4080

ggcaacagca ccggcaccct gatggtgttc ttcggcaacg tggacagcag cggcatcaag     4140

cacaacatct tcaacccccc catcattgcc cggtacatcc ggctgcaccc cacccactac     4200

agcatccggt ccaccctgcg gatggaactg atgggctgcg acctgaacag ctgctccatg     4260

cctctgggca tggaaagcaa ggccatcagc gacgcccaga tcacagccag cagctacttc     4320

accaacatgt tcgccacctg gtccccatcc aaggccagac tgcatctgca gggcagaagc     4380

aatgcctggc ggcctcaggt caacaacccc aaagaatggc tccaggtgga cttccagaaa     4440

accatgaagg tcacaggcgt gaccacccag ggcgtgaagt ccctgctgac ctctatgtac     4500

gtgaaagagt tcctgatctc cagcagccag gacggccacc agtggaccct gttctttcag     4560

aacggcaaag tgaaagtgtt ccagggcaac caggactcct tcacccccgt ggtcaactcc     4620

ctggaccccc cactgctgac cagatacctg agaatccacc cccagagctg ggtgcaccag     4680

atcgccctga gaatggaagt gctgggatgc gaggcccagg atctgtacgg atctgggggc     4740

agtggcggat ccgggggaag cggctcactg gccgaggcaa aagaggccgc aaacgccgaa     4800

ctggattcat atggcgtgtc agatttctat aagagactga ttgacaaagc aaagaccgtg     4860

gaaggggtgg aagcactgaa ggacgcaatc ctggcagccc tgcccggatc tggcggaagc     4920

ggggggagtg gcggctctgg aagcctggca gaagcaaaag aggcagctaa cgcagagctg     4980

gatagttacg gcgtgtcaga cttttacaaa cgcctgattg acaaggccaa aaccgtggaa     5040

ggcgtggaag cactgaaaga tgcaattctg gccgcactgc cctga                     5085


<210> 55
<211> 4890
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD2woLG_SC na

<400> 55
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gccccggtcc     2280

ttcagccaga acccccccgt gctgctggcc gaagccaaag aagccgccaa cgccgagctg     2340

gacagctatg gcgtgtccga cttctacaag cggctgatcg acaaggccaa gacagtggaa     2400

ggcgtggaag ctctgaagga tgccatcctg gccgctctgc ctctggccga ggctaaagag     2460

gctgctaacg cagaactgga ctcttacggg gtgtccgatt tttacaaaag actgattgat     2520

aaggctaaaa ctgtggaagg ggtggaagcc ctgaaagacg ctattctggc tgccctgccc     2580

cagagcgacc aggaagagat cgactacgac gacaccatca gcgtcgagat gaagaaagag     2640

gacttcgaca tctacgacga ggacgagaac cagagccccc ggtccttcca gaagaaaacc     2700

cggcactact ttatcgccgc cgtggaacgg ctgtgggact acggcatgag cagcagcccc     2760

cacgtgctgc ggaatagagc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2820

caggagttca ccgacggcag cttcacccag cctctgtacc ggggcgagct gaacgagcac     2880

ctgggcctgc tgggccccta catccgggcc gaggtggaag ataacatcat ggtcaccttc     2940

cggaaccagg ccagccggcc ctacagcttc tacagcagcc tgatctccta cgaagaggac     3000

cagcggcagg gcgccgagcc ccggaagaac ttcgtgaagc ccaacgagac aaagacctac     3060

ttctggaagg tgcagcacca catggccccc accaaggacg aattcgactg caaggcctgg     3120

gcctacttca gcgacgtgga cctggaaaag gacgtgcaca gcggcctgat cggccccctg     3180

ctcgtgtgcc acaccaacac cctgaacccc gcccacggcc ggcaggtcac agtgcaggaa     3240

tttgccctgt tcttcaccat cttcgacgag actaagagct ggtacttcac cgagaacatg     3300

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcccacctt caaagagaac     3360

taccggttcc acgccatcaa tggctacatc atggacaccc tgcccggcct ggtcatggcc     3420

caggaccaga gaatccggtg gtatctgctg agcatgggca gcaacgagaa catccacagc     3480

atccacttca gcggccacgt gttcaccgtg cggaagaaag aagagtacaa gatggccctg     3540

tacaacctgt accccggcgt gttcgaaaca gtggaaatgc tgcccagcaa ggccggcatc     3600

tggcgggtgg aatgtctgat cggcgagcat ctgcacgccg gcatgtccac cctgtttctg     3660

gtgtacagca acaagtgcca gacccccctg ggcatggcca gcggccacat ccgggatttc     3720

cagatcaccg cctccggcca gtacggccag tgggccccta aactggcccg gctgcactac     3780

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3840

ctggccccca tgattatcca cggcatcaag acacagggcg ccagacagaa gttcagcagc     3900

ctgtacatca gccagttcat catcatgtac agcctggatg gcaagaagtg gcagacctac     3960

cggggcaaca gcaccggcac cctgatggtg ttcttcggca acgtggacag cagcggcatc     4020

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     4080

tacagcatcc ggtccaccct gcggatggaa ctgatgggct gcgacctgaa cagctgctcc     4140

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     4200

ttcaccaaca tgttcgccac ctggtcccca tccaaggcca gactgcatct gcagggcaga     4260

agcaatgcct ggcggcctca ggtcaacaac cccaaagaat ggctccaggt ggacttccag     4320

aaaaccatga aggtcacagg cgtgaccacc cagggcgtga agtccctgct gacctctatg     4380

tacgtgaaag agttcctgat ctccagcagc caggacggcc accagtggac cctgttcttt     4440

cagaacggca aagtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtcaac     4500

tccctggacc ccccactgct gaccagatac ctgagaatcc acccccagag ctgggtgcac     4560

cagatcgccc tgagaatgga agtgctggga tgcgaggccc aggatctgta cctggctgag     4620

gcaaaagaag cagcaaacgc cgaactggat tcctacggcg tgtcagactt ctataagaga     4680

ctgattgaca aagccaaaac cgtggaaggc gtggaagcac tgaaggacgc aattctggcc     4740

gcactgcccc tggcagaagc aaaagaggcc gctaacgctg agctggattc atatggggtg     4800

tcagatttct acaaacgcct gatcgacaaa gcaaaaacag tggaaggggt ggaagccctg     4860

aaggacgcca tcctggcagc cctgccatga                                      4890


<210> 56
<211> 5337
<212> DNA
<213> Artificial Sequence


<220> 
<223> AbD2CD2_SC na

<400> 56
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcctcggagc     2280

ttcagccaga atcctcctgt gctgtccaaa aacaatgcca ttgagccccg gtcattctcc     2340

cagaactcta gacacccaag cctggccgaa gccaaagaag ccgctaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgata aggccaagac cgtggaaggc     2460

gtggaagccc tgaaagatgc tattctggcc gctctgcctg gaagcggagg tagcggagga     2520

tctggcggtt ctggcagcgg atctaagaac aatgctatcg aaccccgctc ctttagccag     2580

aacagcagac acccttctgg aagtggtggt tctggtggat ccggcggatc tggatctctg     2640

gcagaggcta aagaggccgc caacgctgaa ctcgactcct atggggtgtc cgatttttac     2700

aaacgcctca ttgacaaggc caaaacagtc gagggcgtcg aggctctgaa ggatgccatt     2760

cttgctgccc tgccatctaa aaacaacgca atagagccca gatccttcag tcagaacagt     2820

cggcacccca gccagagcga ccaagaggaa atcgacttcg acgacaccat cagcgtcgag     2880

atgaagaaag aggacttcga catcttcgac gaggacgaga atcagagccc cagaagcttc     2940

cagaaaaaga cccggcacta ctttatcgcc gccgtggaaa gactgtggga ctacggaatg     3000

agcagcagcc ctcacgtgct gagaaataga gcacagagcg gcagcgtgcc ccagttcaag     3060

aaagtggtgt tccaagagtt caccgacggc agcttcaccc agcctctgta tagaggcgag     3120

ctgaatgagc acctgggcct gctgggacct tatatcagag ccgaggtgga agataacatc     3180

atggtcacct tccggaacca ggccagcaga ccctacagct tctacagcag cctgatcagc     3240

tacgaagagg accagagaca gggcgccgag cctagaaaga acttcgtgaa gcccaacgag     3300

acaaagacct acttttggaa ggtgcagcac cacatggccc ctaccaagga cgaattcgat     3360

tgcaaggcct gggcctactt cagcgacgtg gacctggaaa aggatgtgca ctctggcctg     3420

atcggccctc tgctcgtgtg tcacaccaac acactgaacc ccgctcacgg cagacaagtg     3480

accgtgcaag agttcgccct gttcttcacc atcttcgacg agacaaagag ctggtacttc     3540

accgagaaca tggaacggaa ctgcagagcc ccttgcaaca tccagatgga agatcccacc     3600

ttcaaagaga actaccggtt ccacgccatc aacggctaca tcatggatac cctgcctggc     3660

ctggttatgg cccaggacca gagaatcaga tggtatctgc tgagcatggg cagcaacgag     3720

aacatccaca gcatccactt cagcggccac gtgttcaccg tgcggaagaa agaagagtac     3780

aagatggccc tgtacaatct gtaccccggc gtgttcgaga cagtggaaat gctgccttct     3840

aaggccggca tttggagagt ggaatgtctg atcggagagc atctgcacgc cggcatgagc     3900

accctgtttc tggtgtacag caacaagtgt cagacccctc tcggcatggc ctccggccac     3960

atcagagatt ttcagatcac agccagcggc cagtatggcc agtgggctcc taaactggcc     4020

agactgcact acagcggcag catcaatgcc tggtccacca aagagccctt cagctggatt     4080

aaggtggacc tgctggcccc tatgatcatc cacggcatca aaacacaggg cgccagacag     4140

aagttcagca gcctgtacat cagccagttc atcatcatgt acagcctgga cggcaagaag     4200

tggcagacct acagaggcaa tagcaccggc acactgatgg tgttcttcgg caatgtggac     4260

agcagcggca tcaagcacaa catcttcaac cctccaatca ttgcccggta catccggctg     4320

caccccacac actacagcat ccggtctacc ctgagaatgg aactgatggg ctgcgacctg     4380

aacagctgta gcatgcccct cggaatggaa agcaaggcca tcagcgacgc ccagatcacc     4440

gcctccagct acttcaccaa catgttcgcc acttggagcc cctccaaagc cagactccat     4500

ctgcaaggca gatctaacgc ttggaggccc caagtgaaca accccaaaga gtggctgcag     4560

gtcgacttcc agaaaaccat gaaggtcaca ggcgtgacaa cccagggcgt gaagtctctg     4620

ctgacctcta tgtacgtgaa agagttcctg atcagcagca gccaggacgg ccaccagtgg     4680

accctgtttt tccagaacgg caaagtgaag gtgttccagg gcaaccagga cagcttcacc     4740

cctgtggtca atagcctgga tcctccactg ctgaccagat acctgcggat tcaccctcag     4800

agctgggtgc accagatcgc tctcagaatg gaagtgctgg gatgtgaagc ccaggatctg     4860

tactccaaga acaacgccat cgagcccaga agcttcagcc agaactctag acacccaagc     4920

ctggccgaag ccaaagaagc cgctaacgcc gagctggata gctacggcgt gtccgacttc     4980

tacaagcggc tgatcgataa ggccaagacc gtggaaggcg tggaagccct gaaagatgcc     5040

attctggctg ctctgcctgg aagcggagga agtggtggat ctggcggttc tggctccggc     5100

agcaaaaaca atgccattga gcctcggagc ttctcccaga acagcagaca tccttctgga     5160

tcaggcggta gcggaggatc cggcggatct ggatctctgg ctgaggctaa agaggccgcc     5220

aacgctgaac tcgactccta tggggtgtcc gatttttaca aacgcctcat tgacaaggcc     5280

aaaacagtcg agggcgtcga ggctctgaag gatgctattc ttgccgcact gccctga        5337


<210> 57
<211> 138
<212> DNA
<213> Artificial Sequence


<220> 
<223> optimized DNA sequence encoding SEQ ID NO: 46

<400> 57
ctggctgaag caaaagaagc agccaatgcg gaactggatt cttatggcgt gagcgatttt     60

tataaacgcc tgatcgataa agcaaaaacc gttgaaggtg ttgaagcact gaaagatgcg    120

attctggcag cactgccg                                                  138


<210> 58
<211> 42
<212> DNA
<213> Artificial Sequence


<220> 
<223> exemplary DNA encoding Glycine-serine Linker G1 of SEQ ID NO:40

<400> 58
ggatcaggag gttcaggagg aagtggtgga tctggaagtg ga                        42


<210> 59
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> exemplary DNA encoding Glycine-serine Linker G2 of SEQ ID NO:41

<400> 59
ggcggcagcg gcggcggcag cggcggcggc agcggc                               36


<210> 60
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19
<223> Signal sequence

<220> 
<223> FVIII-6rs - human FVIII B-domain deleted

<220> 
<221> DOMAIN
<222> 20..348
<223> A1

<220> 
<221> DOMAIN
<222> 349..398
<223> a1

<220> 
<221> DOMAIN
<222> 399..730
<223> A2

<220> 
<221> DOMAIN
<222> 731..759
<223> a2

<220> 
<221> DOMAIN
<222> 760..849
<223> truncated B-domain

<220> 
<221> DOMAIN
<222> 850..894
<223> a3

<220> 
<221> DOMAIN
<222> 895..1221
<223> A3

<220> 
<221> DOMAIN
<222> 1222..1374
<223> C1

<220> 
<221> DOMAIN
<222> 1375..1533
<223> C2

<400> 60
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 61
<211> 1457
<212> PRT
<213> Artificial Sequence


<220> 
<223> Refacto - human FVIII B-domain deleted

<400> 61
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 
Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 
Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     
Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         
Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             
Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 
Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 
Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         
Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             
Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 
Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 
Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     
Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         
Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe 
        995                 1000                1005            
Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys 
    1010                1015                1020                
Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn 
1025                1030                1035                1040
Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly 
                1045                1050                1055    
Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met 
            1060                1065                1070        
Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His Val Phe 
        1075                1080                1085            
Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr 
    1090                1095                1100                
Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile 
1105                1110                1115                1120
Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser 
                1125                1130                1135    
Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met 
            1140                1145                1150        
Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr 
        1155                1160                1165            
Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile 
    1170                1175                1180                
Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu 
1185                1190                1195                1200
Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln 
                1205                1210                1215    
Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu 
            1220                1225                1230        
Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu 
        1235                1240                1245            
Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile 
    1250                1255                1260                
Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His 
1265                1270                1275                1280
Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu 
                1285                1290                1295    
Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp 
            1300                1305                1310        
Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp 
        1315                1320                1325            
Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp 
    1330                1335                1340                
Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln 
1345                1350                1355                1360
Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu 
                1365                1370                1375    
Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp 
            1380                1385                1390        
Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe 
        1395                1400                1405            
Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro 
    1410                1415                1420                
Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His 
1425                1430                1435                1440
Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu 
                1445                1450                1455    
Tyr 
    

<210> 62
<211> 1463
<212> PRT
<213> Artificial Sequence


<220> 
<221> SOURCE
<222> 1..10
<223> Afstyla - human FVIII B-domain deleted single chain

<220> 
<221> SIGNAL
<222> 1..19
<223> signal sequence

<400> 62
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             
Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Thr 
    770                 775                 780                 
Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser 
785                 790                 795                 800 
Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn 
                805                 810                 815     
Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala 
            820                 825                 830         
Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val 
        835                 840                 845             
Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val 
    850                 855                 860                 
Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg 
865                 870                 875                 880 
Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
                885                 890                 895     
Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg 
            900                 905                 910         
Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg 
        915                 920                 925             
Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys 
    930                 935                 940                 
Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu 
945                 950                 955                 960 
Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys 
                965                 970                 975     
Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn 
            980                 985                 990         
Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala 
        995                 1000                1005            
Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu 
    1010                1015                1020                
Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp 
1025                1030                1035                1040
Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile 
                1045                1050                1055    
Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg 
            1060                1065                1070        
Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His 
        1075                1080                1085            
Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met 
    1090                1095                1100                
Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu 
1105                1110                1115                1120
Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His 
                1125                1130                1135    
Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys 
            1140                1145                1150        
Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile 
        1155                1160                1165            
Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu 
    1170                1175                1180                
His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser 
1185                1190                1195                1200
Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys 
                1205                1210                1215    
Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe 
            1220                1225                1230        
Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly 
        1235                1240                1245            
Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser 
    1250                1255                1260                
Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile 
1265                1270                1275                1280
Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu 
                1285                1290                1295    
Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu 
            1300                1305                1310        
Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr 
        1315                1320                1325            
Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln 
    1330                1335                1340                
Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp 
1345                1350                1355                1360
Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr 
                1365                1370                1375    
Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu 
            1380                1385                1390        
Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn 
        1395                1400                1405            
Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val 
    1410                1415                1420                
Val Asn Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His 
1425                1430                1435                1440
Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly 
                1445                1450                1455    
Cys Glu Ala Gln Asp Leu Tyr 
            1460            

<210> 63
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-19M

<220> 
<221> DOMAIN
<222> 20..348
<223> A1

<220> 
<221> MUTAGEN
<222> 79
<223> N79S

<220> 
<221> MUTAGEN
<222> 112
<223> S112T

<220> 
<221> MUTAGEN
<222> 160
<223> L160S

<220> 
<221> MUTAGEN
<222> 171
<223> L171Q

<220> 
<221> MUTAGEN
<222> 184
<223> V184A

<220> 
<221> MUTAGEN
<222> 223
<223> N233D

<220> 
<221> MUTAGEN
<222> 265
<223> I265T

<220> 
<221> MUTAGEN
<222> 299
<223> N299D

<220> 
<221> DOMAIN
<222> 349..398
<223> a1

<220> 
<221> DOMAIN
<222> 399..730
<223> A2

<220> 
<221> MUTAGEN
<222> 426
<223> Y426H

<220> 
<221> MUTAGEN
<222> 507
<223> S507E

<220> 
<221> MUTAGEN
<222> 555
<223> F555H

<220> 
<221> MUTAGEN
<222> 616
<223> N616E

<220> 
<221> MUTAGEN
<222> 706
<223> L706N

<220> 
<221> DOMAIN
<222> 731..759
<223> a2

<220> 
<221> MUTAGEN
<222> 748
<223> Y748S

<220> 
<221> DOMAIN
<222> 760..849
<223> truncated B-domain

<220> 
<221> DOMAIN
<222> 850..894
<223> a3

<220> 
<221> DOMAIN
<222> 895..1221
<223> A3

<220> 
<221> MUTAGEN
<222> 1019
<223> K1837E

<220> 
<221> MUTAGEN
<222> 1220
<223> N2038D

<220> 
<221> DOMAIN
<222> 1222..1374
<223> C1

<220> 
<221> MUTAGEN
<222> 1259
<223> S2077G

<220> 
<221> DOMAIN
<222> 1375..1533
<223> C2

<220> 
<221> MUTAGEN
<222> 1497
<223> S2315T

<220> 
<221> MUTAGEN
<222> 1515
<223> V2333A

<400> 63
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asp Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Gly Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Thr Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 64
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-18M

<400> 64
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asp Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Gly Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Thr Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 65
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-15M

<400> 65
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 66
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-A1-7M

<400> 66
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 67
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-A2-4M

<400> 67
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 68
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-BA3-1M

<400> 68
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 69
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-A3C2-4M

<400> 69
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asp Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Gly Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Thr Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 70
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-GOF1

<400> 70
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 71
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-GOF2

<400> 71
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 72
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-LS1

<400> 72
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asp Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 73
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-LS2

<220> 
<221> MUTAGEN
<222> 112
<223> S112T

<220> 
<221> MUTAGEN
<222> 426
<223> Y426H

<220> 
<221> MUTAGEN
<222> 754
<223> N754D

<220> 
<221> MUTAGEN
<222> 1019
<223> K1837E

<220> 
<221> MUTAGEN
<222> 1220
<223> N2038D

<400> 73
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asp Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asp Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 74
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 74
Asp His Leu Phe Asn Ile Ala Lys Pro Arg Pro Pro Trp Met Gly 
1               5                   10                  15  

<210> 75
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 75
Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
1               5                   10                  15      
Ser Leu 
        

<210> 76
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 76
Val Trp Gln Val Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu 
1               5                   10                  15      



<210> 77
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 77
Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser His Val Asp Leu 
1               5                   10                  15      
Val Lys 
        

<210> 78
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 78
His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
1               5                   10                  15      



<210> 79
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 79
Thr Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu 
1               5                   10                  15      
Gly Lys 
        

<210> 80
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 80
Gly Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp 
1               5                   10                  15  

<210> 81
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 81
Met His Thr Val Asn Gly Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile 
1               5                   10                  15      
Gly 
    

<210> 82
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 82
Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
1               5                   10                  15      
Ser 
    

<210> 83
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 83
Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu 
1               5                   10                  15      
Gly 
    

<210> 84
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 84
Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile 
1               5                   10                  15      
Gly Arg Lys 
            

<210> 85
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 85
Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr 
1               5                   10                  15      
Asn Ile Tyr 
            

<210> 86
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 86
Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val 
1               5                   10                  15      
Lys His Leu 
            

<210> 87
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 87
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
1               5                   10                  15      
Asp Leu Ala Ser Gly Leu 
            20          

<210> 88
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 88
Thr Glu Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu 
1               5                   10                  15      
Glu Asp 
        

<210> 89
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 89
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
1               5                   10                  15      
Phe Asp Ser 
            

<210> 90
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 90
Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe 
1               5                   10                  15      
Leu 
    

<210> 91
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 91
Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Ile Leu 
1               5                   10                  15  

<210> 92
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 92
Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser 
1               5                   10                  15      



<210> 93
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 93
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala 
1               5                   10                  15  

<210> 94
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 94
Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
1               5                   10                  15      



<210> 95
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 95
Lys Thr Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Lys Asp 
1               5                   10                  15      



<210> 96
<211> 21
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 96
Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr 
1               5                   10                  15      
Ile Met Asp Thr Leu 
            20      

<210> 97
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 97
Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn 
1               5                   10                  15      
Ile His Ser 
            

<210> 98
<211> 16
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 98
Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu 
1               5                   10                  15      



<210> 99
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 99
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
1               5                   10                  15      
Thr Lys Glu 
            

<210> 100
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 100
Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly 
1               5                   10                  15      
Lys Lys Trp 
            

<210> 101
<211> 18
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 101
Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met 
1               5                   10                  15      
Val Phe 
        

<210> 102
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 102
Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser 
1               5                   10                  15      
Thr 
    

<210> 103
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 103
Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
1               5                   10                  15  

<210> 104
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 104
Lys Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln 
1               5                   10                  15      
Val 
    

<210> 105
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 105
Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr 
1               5                   10                  15      
Thr 
    

<210> 106
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 106
Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 
1               5                   10                  15      
His Gln Trp 
            

<210> 107
<211> 19
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 107
Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu 
1               5                   10                  15      
Thr Arg Tyr 
            

<210> 108
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 108
Pro Gln Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu 
1               5                   10                  15  

<210> 109
<211> 1533
<212> PRT
<213> Artificial Sequence


<220> 
<221> SIGNAL
<222> 1..19

<220> 
<223> FVIII-A1A2-3M

<400> 109
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asp Pro Leu Ala Trp 
        755                 760                 765             
Asp Asn His Tyr Gly Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln 
    770                 775                 780                 
Glu Lys Ser Pro Glu Lys Thr Ala Phe Lys Lys Lys Asp Thr Ile Leu 
785                 790                 795                 800 
Ser Leu Asn Ala Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu 
                805                 810                 815     
Gly Gln Asn Lys Pro Glu Ile Glu Val Thr Trp Ala Lys Gln Gly Arg 
            820                 825                 830         
Thr Glu Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln 
        835                 840                 845             
Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp 
    850                 855                 860                 
Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile 
865                 870                 875                 880 
Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr 
                885                 890                 895     
Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            900                 905                 910         
Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val 
        915                 920                 925             
Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    930                 935                 940                 
Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
945                 950                 955                 960 
Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                965                 970                 975     
Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            980                 985                 990         
Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val 
        995                 1000                1005            
Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His Met 
    1010                1015                1020                
Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
1025                1030                1035                1040
Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu 
                1045                1050                1055    
Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            1060                1065                1070        
Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys 
        1075                1080                1085            
Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys 
    1090                1095                1100                
Asn Ile Gln Met Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His 
1105                1110                1115                1120
Ala Ile Asn Gly Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala 
                1125                1130                1135    
Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu 
            1140                1145                1150        
Asn Ile His Ser Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys 
        1155                1160                1165            
Lys Glu Glu Tyr Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe 
    1170                1175                1180                
Glu Thr Val Glu Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu 
1185                1190                1195                1200
Cys Leu Ile Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu 
                1205                1210                1215    
Val Tyr Ser Asn Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His 
            1220                1225                1230        
Ile Arg Asp Phe Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala 
        1235                1240                1245            
Pro Lys Leu Ala Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser 
    1250                1255                1260                
Thr Lys Glu Pro Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met 
1265                1270                1275                1280
Ile Ile His Gly Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser 
                1285                1290                1295    
Leu Tyr Ile Ser Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys 
            1300                1305                1310        
Trp Gln Thr Tyr Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe 
        1315                1320                1325            
Gly Asn Val Asp Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro 
    1330                1335                1340                
Ile Ile Ala Arg Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg 
1345                1350                1355                1360
Ser Thr Leu Arg Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser 
                1365                1370                1375    
Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr 
            1380                1385                1390        
Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys 
        1395                1400                1405            
Ala Arg Leu His Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val 
    1410                1415                1420                
Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys 
1425                1430                1435                1440
Val Thr Gly Val Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met 
                1445                1450                1455    
Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp 
            1460                1465                1470        
Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln 
        1475                1480                1485            
Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro Leu Leu Thr 
    1490                1495                1500                
Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln Ile Ala Leu 
1505                1510                1515                1520
Arg Met Glu Val Leu Gly Cys Glu Ala Gln Asp Leu Tyr 
                1525                1530            

<210> 110
<211> 4605
<212> DNA
<213> Artificial Sequence


<220> 
<223> FVIII-19M na

<400> 110
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttctccatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccacccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtctcc      480

aaagaaaacg gccccatggc ctccgacccc cagtgcctga cctacagcta cctgagccac      540

gtggacctgg ccaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgaccggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcgggaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagccacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacga gagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccgagcc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc cagcctgctg agcaagaaca acgccatcga gcctcggagc     2280

ttctcccagg atcctctggc ctgggacaac cactacggca cccagatccc caaagaggaa     2340

tggaagtccc aggaaaagag ccccgagaaa accgccttca agaagaagga caccatcctg     2400

agcctgaacg cctgcgagag caaccacgcc attgccgcca tcaacgaggg ccagaacaag     2460

cccgagatcg aagtgacctg ggctaagcag ggccggaccg agagactgtg cagccagaac     2520

ccccccgtgc tgaagcggca ccagagagag atcacccgga ccaccctgca gagcgaccag     2580

gaagagatcg actacgacga caccatcagc gtcgagatga agaaagagga cttcgacatc     2640

tacgacgagg acgagaacca gagcccccgg tccttccaga agaaaacccg gcactacttt     2700

atcgccgccg tggaacggct gtgggactac ggcatgagca gcagccccca cgtgctgcgg     2760

aatagagccc agagcggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc     2820

gacggcagct tcacccagcc tctgtaccgg ggcgagctga acgagcacct gggcctgctg     2880

ggcccctaca tccgggccga ggtggaagat aacatcatgg tcaccttccg gaaccaggcc     2940

agccggccct acagcttcta cagcagcctg atctcctacg aagaggacca gcggcagggc     3000

gccgagcccc ggaagaactt cgtgaagccc aacgagacaa agacctactt ctgggaggtg     3060

cagcaccaca tggcccccac caaggacgaa ttcgactgca aggcctgggc ctacttcagc     3120

gacgtggacc tggaaaagga cgtgcacagc ggcctgatcg gccccctgct cgtgtgccac     3180

accaacaccc tgaaccccgc ccacggccgg caggtcacag tgcaggaatt tgccctgttc     3240

ttcaccatct tcgacgagac taagagctgg tacttcaccg agaacatgga acggaactgc     3300

agagccccct gcaacatcca gatggaagat cccaccttca aagagaacta ccggttccac     3360

gccatcaatg gctacatcat ggacaccctg cccggcctgg tcatggccca ggaccagaga     3420

atccggtggt atctgctgag catgggcagc aacgagaaca tccacagcat ccacttcagc     3480

ggccacgtgt tcaccgtgcg gaagaaagaa gagtacaaga tggccctgta caacctgtac     3540

cccggcgtgt tcgagacagt ggaaatgctg cccagcaagg ccggcatctg gcgggtggaa     3600

tgtctgatcg gcgagcatct gcacgccggc atgtccaccc tgtttctggt gtacagcgac     3660

aagtgccaga cccccctggg catggccagc ggccacatcc gggatttcca gatcaccgcc     3720

tccggccagt acggccagtg ggcccctaaa ctggcccggc tgcactacag cggcggcatc     3780

aacgcctggt ccaccaaaga gcccttcagc tggatcaagg tggacctgct ggcccccatg     3840

attatccacg gcatcaagac acagggcgcc agacagaagt tcagcagcct gtacatcagc     3900

cagttcatca tcatgtacag cctggatggc aagaagtggc agacctaccg gggcaacagc     3960

accggcaccc tgatggtgtt cttcggcaac gtggacagca gcggcatcaa gcacaacatc     4020

ttcaaccccc ccatcattgc ccggtacatc cggctgcacc ccacccacta cagcatccgg     4080

tccaccctgc ggatggaact gatgggctgc gacctgaaca gctgctccat gcctctgggc     4140

atggaaagca aggccatcag cgacgcccag atcacagcca gcagctactt caccaacatg     4200

ttcgccacct ggtccccatc caaggccaga ctgcatctgc agggcagaag caatgcctgg     4260

cggcctcagg tcaacaaccc caaagaatgg ctccaggtgg acttccagaa aaccatgaag     4320

gtcacaggcg tgaccaccca gggcgtgaag tccctgctga cctctatgta cgtgaaagag     4380

ttcctgatct ccagcagcca ggacggccac cagtggaccc tgttctttca gaacggcaaa     4440

gtgaaagtgt tccagggcaa ccaggactcc ttcacccccg tggtcaacac cctggacccc     4500

ccactgctga ccagatacct gagaatccac ccccagagct gggcccacca gatcgccctg     4560

agaatggaag tgctgggatg cgaggcccag gatctgtact gatag                     4605


<210> 111
<211> 4605
<212> DNA
<213> Artificial Sequence


<220> 
<223> FVIII-6rs na

<400> 111
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc cagattcccc ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtcgagttca ccgaccacct gttcaatatc      240

gccaagccca gacccccctg gatgggcctg ctgggcccta caatccaggc cgaggtgtac      300

gacaccgtgg tcatcaccct gaagaacatg gccagccacc ccgtgtccct gcacgccgtg      360

ggcgtgtcct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgc      420

gagaaagagg acgacaaagt ctttcctggc ggcagccata cctacgtgtg gcaggtcctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tcaaggacct gaacagcggc ctgatcggcg ccctgctcgt gtgcagagag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcctaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggac tgatcggctg ccaccggaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca ccttcctcgt gcggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagcagcc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtcgt cagattcgat     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccctct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacaccctg     1440

ctgattatct tcaagaacca ggccagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag cagacggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggggagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggccctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aacagaagct ggtatctgac cgagaatatc cagcggttcc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc cccttctccg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg agcaagaaca acgccatcga gcctcggagc     2280

ttctcccagg atcctctggc ctgggacaac cactacggca cccagatccc caaagaggaa     2340

tggaagtccc aggaaaagag ccccgagaaa accgccttca agaagaagga caccatcctg     2400

agcctgaacg cctgcgagag caaccacgcc attgccgcca tcaacgaggg ccagaacaag     2460

cccgagatcg aagtgacctg ggctaagcag ggccggaccg agagactgtg cagccagaac     2520

ccccccgtgc tgaagcggca ccagagagag atcacccgga ccaccctgca gagcgaccag     2580

gaagagatcg actacgacga caccatcagc gtcgagatga agaaagagga cttcgacatc     2640

tacgacgagg acgagaacca gagcccccgg tccttccaga agaaaacccg gcactacttt     2700

atcgccgccg tggaacggct gtgggactac ggcatgagca gcagccccca cgtgctgcgg     2760

aatagagccc agagcggcag cgtgccccag ttcaagaaag tggtgttcca ggagttcacc     2820

gacggcagct tcacccagcc tctgtaccgg ggcgagctga acgagcacct gggcctgctg     2880

ggcccctaca tccgggccga ggtggaagat aacatcatgg tcaccttccg gaaccaggcc     2940

agccggccct acagcttcta cagcagcctg atctcctacg aagaggacca gcggcagggc     3000

gccgagcccc ggaagaactt cgtgaagccc aacgagacaa agacctactt ctggaaggtg     3060

cagcaccaca tggcccccac caaggacgaa ttcgactgca aggcctgggc ctacttcagc     3120

gacgtggacc tggaaaagga cgtgcacagc ggcctgatcg gccccctgct cgtgtgccac     3180

accaacaccc tgaaccccgc ccacggccgg caggtcacag tgcaggaatt tgccctgttc     3240

ttcaccatct tcgacgagac taagagctgg tacttcaccg agaacatgga acggaactgc     3300

agagccccct gcaacatcca gatggaagat cccaccttca aagagaacta ccggttccac     3360

gccatcaatg gctacatcat ggacaccctg cccggcctgg tcatggccca ggaccagaga     3420

atccggtggt atctgctgag catgggcagc aacgagaaca tccacagcat ccacttcagc     3480

ggccacgtgt tcaccgtgcg gaagaaagaa gagtacaaga tggccctgta caacctgtac     3540

cccggcgtgt tcgagacagt ggaaatgctg cccagcaagg ccggcatctg gcgggtggaa     3600

tgtctgatcg gcgagcatct gcacgccggc atgtccaccc tgtttctggt gtacagcaac     3660

aagtgccaga cccccctggg catggccagc ggccacatcc gggatttcca gatcaccgcc     3720

tccggccagt acggccagtg ggcccctaaa ctggcccggc tgcactacag cggcagcatc     3780

aacgcctggt ccaccaaaga gcccttcagc tggatcaagg tggacctgct ggcccccatg     3840

attatccacg gcatcaagac acagggcgcc agacagaagt tcagcagcct gtacatcagc     3900

cagttcatca tcatgtacag cctggatggc aagaagtggc agacctaccg gggcaacagc     3960

accggcaccc tgatggtgtt cttcggcaac gtggacagca gcggcatcaa gcacaacatc     4020

ttcaaccccc ccatcattgc ccggtacatc cggctgcacc ccacccacta cagcatccgg     4080

tccaccctgc ggatggaact gatgggctgc gacctgaaca gctgctccat gcctctgggc     4140

atggaaagca aggccatcag cgacgcccag atcacagcca gcagctactt caccaacatg     4200

ttcgccacct ggtccccatc caaggccaga ctgcatctgc agggcagaag caatgcctgg     4260

cggcctcagg tcaacaaccc caaagaatgg ctccaggtgg acttccagaa aaccatgaag     4320

gtcacaggcg tgaccaccca gggcgtgaag tccctgctga cctctatgta cgtgaaagag     4380

ttcctgatct ccagcagcca ggacggccac cagtggaccc tgttctttca gaacggcaaa     4440

gtgaaagtgt tccagggcaa ccaggactcc ttcacccccg tggtcaactc cctggacccc     4500

ccactgctga ccagatacct gagaatccac ccccagagct gggtgcacca gatcgccctg     4560

agaatggaag tgctgggatg cgaggcccag gatctgtact gatag                     4605


<210> 112
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Immunogenic cluster identified in FVIII

<400> 112
Gly Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser 
1               5                   10                  15      



<210> 113
<211> 1445
<212> PRT
<213> Artificial Sequence


<220> 
<223> Single chain V0-19M (AC-19M_SC)

<400> 113
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
    770                 775                 780                 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
785                 790                 795                 800 
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
                805                 810                 815     
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
            820                 825                 830         
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
        835                 840                 845             
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
    850                 855                 860                 
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
865                 870                 875                 880 
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
                885                 890                 895     
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
            900                 905                 910         
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
        915                 920                 925             
Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
    930                 935                 940                 
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
945                 950                 955                 960 
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
                965                 970                 975     
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
            980                 985                 990         
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
        995                 1000                1005            
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
    1010                1015                1020                
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
1025                1030                1035                1040
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
                1045                1050                1055    
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
            1060                1065                1070        
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
        1075                1080                1085            
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
    1090                1095                1100                
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
1105                1110                1115                1120
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp Lys Cys Gln Thr 
                1125                1130                1135    
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
            1140                1145                1150        
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
        1155                1160                1165            
Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
    1170                1175                1180                
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
1185                1190                1195                1200
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
                1205                1210                1215    
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
            1220                1225                1230        
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
        1235                1240                1245            
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
    1250                1255                1260                
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
1265                1270                1275                1280
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
                1285                1290                1295    
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
            1300                1305                1310        
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
        1315                1320                1325            
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
    1330                1335                1340                
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
1345                1350                1355                1360
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
                1365                1370                1375    
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
            1380                1385                1390        
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
        1395                1400                1405            
Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
    1410                1415                1420                
Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
1425                1430                1435                1440
Ala Gln Asp Leu Tyr 
                1445

<210> 114
<211> 1778
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD2-19M_SC

<400> 114
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser 
        835                 840                 845             
Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
    850                 855                 860                 
Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu 
865                 870                 875                 880 
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                885                 890                 895     
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            900                 905                 910         
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
        915                 920                 925             
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
    930                 935                 940                 
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
945                 950                 955                 960 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
                965                 970                 975     
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
            980                 985                 990         
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
        995                 1000                1005            
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
    1010                1015                1020                
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
1025                1030                1035                1040
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
                1045                1050                1055    
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
            1060                1065                1070        
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
        1075                1080                1085            
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
    1090                1095                1100                
Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
1105                1110                1115                1120
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
                1125                1130                1135    
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
            1140                1145                1150        
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
        1155                1160                1165            
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
    1170                1175                1180                
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1185                1190                1195                1200
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
                1205                1210                1215    
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
            1220                1225                1230        
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
        1235                1240                1245            
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
    1250                1255                1260                
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
1265                1270                1275                1280
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
                1285                1290                1295    
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp Lys Cys Gln Thr 
            1300                1305                1310        
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
        1315                1320                1325            
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
    1330                1335                1340                
Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
1345                1350                1355                1360
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
                1365                1370                1375    
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
            1380                1385                1390        
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
        1395                1400                1405            
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
    1410                1415                1420                
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1425                1430                1435                1440
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
                1445                1450                1455    
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
            1460                1465                1470        
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
        1475                1480                1485            
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
    1490                1495                1500                
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
1505                1510                1515                1520
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
                1525                1530                1535    
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
            1540                1545                1550        
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
        1555                1560                1565            
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
    1570                1575                1580                
Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
1585                1590                1595                1600
Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
                1605                1610                1615    
Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
            1620                1625                1630        
Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        1635                1640                1645            
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    1650                1655                1660                
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
1665                1670                1675                1680
Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                1685                1690                1695    
Ser Gly Ser Gly Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
            1700                1705                1710        
Gln Asn Ser Arg His Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        1715                1720                1725            
Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu 
    1730                1735                1740                
Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala 
1745                1750                1755                1760
Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala 
                1765                1770                1775    
Leu Pro 
        

<210> 115
<211> 1594
<212> PRT
<213> Artificial Sequence


<220> 
<223> ALDLCLD-19M_SC

<400> 115
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser 
        835                 840                 845             
Arg His Pro Ser Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr 
    850                 855                 860                 
Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp 
865                 870                 875                 880 
Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe 
                885                 890                 895     
Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro 
            900                 905                 910         
His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys 
        915                 920                 925             
Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu 
    930                 935                 940                 
Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile 
945                 950                 955                 960 
Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala 
                965                 970                 975     
Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp 
            980                 985                 990         
Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu 
        995                 1000                1005            
Thr Lys Thr Tyr Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys 
    1010                1015                1020                
Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu 
1025                1030                1035                1040
Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His 
                1045                1050                1055    
Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu 
            1060                1065                1070        
Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe 
        1075                1080                1085            
Thr Glu Asn Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met 
    1090                1095                1100                
Glu Asp Pro Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly 
1105                1110                1115                1120
Tyr Ile Met Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg 
                1125                1130                1135    
Ile Arg Trp Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser 
            1140                1145                1150        
Ile His Phe Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr 
        1155                1160                1165            
Lys Met Ala Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu 
    1170                1175                1180                
Met Leu Pro Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly 
1185                1190                1195                1200
Glu His Leu His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp 
                1205                1210                1215    
Lys Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe 
            1220                1225                1230        
Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala 
        1235                1240                1245            
Arg Leu His Tyr Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro 
    1250                1255                1260                
Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly 
1265                1270                1275                1280
Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 
                1285                1290                1295    
Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr 
            1300                1305                1310        
Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp 
        1315                1320                1325            
Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg 
    1330                1335                1340                
Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
1345                1350                1355                1360
Met Glu Leu Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly 
                1365                1370                1375    
Met Glu Ser Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr 
            1380                1385                1390        
Phe Thr Asn Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His 
        1395                1400                1405            
Leu Gln Gly Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys 
    1410                1415                1420                
Glu Trp Leu Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val 
1425                1430                1435                1440
Thr Thr Gln Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu 
                1445                1450                1455    
Phe Leu Ile Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe 
            1460                1465                1470        
Gln Asn Gly Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr 
        1475                1480                1485            
Pro Val Val Asn Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg 
    1490                1495                1500                
Ile His Pro Gln Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val 
1505                1510                1515                1520
Leu Gly Cys Glu Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu 
                1525                1530                1535    
Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala 
            1540                1545                1550        
Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe 
        1555                1560                1565            
Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala 
    1570                1575                1580                
Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro 
1585                1590                

<210> 116
<211> 1575
<212> PRT
<213> Artificial Sequence


<220> 
<223> ADLCLD-19M_SC-V1

<400> 116
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly 
    770                 775                 780                 
Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu 
785                 790                 795                 800 
Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys 
                805                 810                 815     
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
            820                 825                 830         
Ser Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val 
        835                 840                 845             
Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln 
    850                 855                 860                 
Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala 
865                 870                 875                 880 
Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu 
                885                 890                 895     
Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val 
            900                 905                 910         
Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly 
        915                 920                 925             
Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu 
    930                 935                 940                 
Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro 
945                 950                 955                 960 
Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln 
                965                 970                 975     
Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr 
            980                 985                 990         
Tyr Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe 
        995                 1000                1005            
Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp 
    1010                1015                1020                
Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr 
1025                1030                1035                1040
Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 
                1045                1050                1055    
Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn 
            1060                1065                1070        
Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro 
        1075                1080                1085            
Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met 
    1090                1095                1100                
Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp 
1105                1110                1115                1120
Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 
                1125                1130                1135    
Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala 
            1140                1145                1150        
Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro 
        1155                1160                1165            
Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu 
    1170                1175                1180                
His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp Lys Cys Gln 
1185                1190                1195                1200
Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr 
                1205                1210                1215    
Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His 
            1220                1225                1230        
Tyr Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp 
        1235                1240                1245            
Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr 
    1250                1255                1260                
Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile 
1265                1270                1275                1280
Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 
                1285                1290                1295    
Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly 
            1300                1305                1310        
Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg 
        1315                1320                1325            
Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu 
    1330                1335                1340                
Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser 
1345                1350                1355                1360
Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 
                1365                1370                1375    
Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly 
            1380                1385                1390        
Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu 
        1395                1400                1405            
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln 
    1410                1415                1420                
Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 
1425                1430                1435                1440
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly 
                1445                1450                1455    
Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 
            1460                1465                1470        
Asn Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro 
        1475                1480                1485            
Gln Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
    1490                1495                1500                
Glu Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser 
1505                1510                1515                1520
Phe Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala 
                1525                1530                1535    
Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg 
            1540                1545                1550        
Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp 
        1555                1560                1565            
Ala Ile Leu Ala Ala Leu Pro 
    1570                1575

<210> 117
<211> 1575
<212> PRT
<213> Artificial Sequence


<220> 
<223> ADLCLD-19M_SC-V2

<400> 117
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
    770                 775                 780                 
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
785                 790                 795                 800 
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
                805                 810                 815     
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
            820                 825                 830         
Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val 
        835                 840                 845             
Glu Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln 
    850                 855                 860                 
Ser Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala 
865                 870                 875                 880 
Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu 
                885                 890                 895     
Arg Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val 
            900                 905                 910         
Phe Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly 
        915                 920                 925             
Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu 
    930                 935                 940                 
Val Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro 
945                 950                 955                 960 
Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln 
                965                 970                 975     
Gly Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr 
            980                 985                 990         
Tyr Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe 
        995                 1000                1005            
Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp 
    1010                1015                1020                
Val His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr 
1025                1030                1035                1040
Leu Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu 
                1045                1050                1055    
Phe Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn 
            1060                1065                1070        
Met Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro 
        1075                1080                1085            
Thr Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met 
    1090                1095                1100                
Asp Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp 
1105                1110                1115                1120
Tyr Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe 
                1125                1130                1135    
Ser Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala 
            1140                1145                1150        
Leu Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro 
        1155                1160                1165            
Ser Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu 
    1170                1175                1180                
His Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp Lys Cys Gln 
1185                1190                1195                1200
Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr 
                1205                1210                1215    
Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His 
            1220                1225                1230        
Tyr Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp 
        1235                1240                1245            
Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr 
    1250                1255                1260                
Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile 
1265                1270                1275                1280
Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn 
                1285                1290                1295    
Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly 
            1300                1305                1310        
Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg 
        1315                1320                1325            
Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu 
    1330                1335                1340                
Met Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser 
1345                1350                1355                1360
Lys Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn 
                1365                1370                1375    
Met Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly 
            1380                1385                1390        
Arg Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu 
        1395                1400                1405            
Gln Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln 
    1410                1415                1420                
Gly Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile 
1425                1430                1435                1440
Ser Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly 
                1445                1450                1455    
Lys Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val 
            1460                1465                1470        
Asn Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro 
        1475                1480                1485            
Gln Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys 
    1490                1495                1500                
Glu Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser 
1505                1510                1515                1520
Phe Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala 
                1525                1530                1535    
Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg 
            1540                1545                1550        
Leu Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp 
        1555                1560                1565            
Ala Ile Leu Ala Ala Leu Pro 
    1570                1575

<210> 118
<211> 1686
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD-19M_SC

<400> 118
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser 
        835                 840                 845             
Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
    850                 855                 860                 
Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu 
865                 870                 875                 880 
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                885                 890                 895     
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            900                 905                 910         
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
        915                 920                 925             
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
    930                 935                 940                 
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
945                 950                 955                 960 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
                965                 970                 975     
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
            980                 985                 990         
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
        995                 1000                1005            
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
    1010                1015                1020                
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
1025                1030                1035                1040
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
                1045                1050                1055    
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
            1060                1065                1070        
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
        1075                1080                1085            
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
    1090                1095                1100                
Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
1105                1110                1115                1120
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
                1125                1130                1135    
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
            1140                1145                1150        
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
        1155                1160                1165            
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
    1170                1175                1180                
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1185                1190                1195                1200
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
                1205                1210                1215    
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
            1220                1225                1230        
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
        1235                1240                1245            
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
    1250                1255                1260                
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
1265                1270                1275                1280
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
                1285                1290                1295    
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asp Lys Cys Gln Thr 
            1300                1305                1310        
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
        1315                1320                1325            
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
    1330                1335                1340                
Ser Gly Gly Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
1345                1350                1355                1360
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
                1365                1370                1375    
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
            1380                1385                1390        
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
        1395                1400                1405            
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
    1410                1415                1420                
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1425                1430                1435                1440
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
                1445                1450                1455    
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
            1460                1465                1470        
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
        1475                1480                1485            
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
    1490                1495                1500                
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
1505                1510                1515                1520
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
                1525                1530                1535    
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
            1540                1545                1550        
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
        1555                1560                1565            
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
    1570                1575                1580                
Thr Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
1585                1590                1595                1600
Ser Trp Ala His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
                1605                1610                1615    
Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
            1620                1625                1630        
Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        1635                1640                1645            
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    1650                1655                1660                
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
1665                1670                1675                1680
Ile Leu Ala Ala Leu Pro 
                1685    

<210> 119
<211> 1778
<212> PRT
<213> Artificial Sequence


<220> 
<223> AD2CD2-15M_SC

<400> 119
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      
Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          
Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              
Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  
Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Ser Ile 
65                  70                  75                  80  
Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      
Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Thr 
            100                 105                 110         
His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             
Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 
Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Ser 
145                 150                 155                 160 
Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Gln Cys Leu Thr Tyr Ser 
                165                 170                 175     
Tyr Leu Ser His Val Asp Leu Ala Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         
Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             
Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 
Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 
Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     
Val Asn Arg Ser Leu Pro Gly Leu Thr Gly Cys His Arg Lys Ser Val 
            260                 265                 270         
Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             
Phe Leu Glu Gly His Thr Phe Leu Val Arg Asp His Arg Gln Ala Ser 
    290                 295                 300                 
Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 
Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     
Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         
Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             
Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 
Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 
Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     
Leu Val Leu Ala Pro Asp Asp Arg Ser His Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         
Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             
Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 
Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 
Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     
His Gly Ile Thr Asp Val Arg Pro Leu Tyr Glu Arg Arg Leu Pro Lys 
            500                 505                 510         
Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             
Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 
Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser His Val Asn Met Glu Arg 
545                 550                 555                 560 
Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     
Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         
Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             
Asn Ile Gln Arg Phe Leu Pro Glu Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 
Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 
Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     
Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         
Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             
Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 
Gly Asn Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 
Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     
Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Ser Leu Leu Ser Lys 
            740                 745                 750         
Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             
Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg 
    770                 775                 780                 
His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp 
785                 790                 795                 800 
Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys 
                805                 810                 815     
Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu 
            820                 825                 830         
Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser 
        835                 840                 845             
Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
    850                 855                 860                 
Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Leu 
865                 870                 875                 880 
Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu Asp Ser Tyr Gly Val 
                885                 890                 895     
Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala Lys Thr Val Glu Gly 
            900                 905                 910         
Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala Leu Pro Ser Lys Asn 
        915                 920                 925             
Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser 
    930                 935                 940                 
Gln Ser Asp Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu 
945                 950                 955                 960 
Met Lys Lys Glu Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser 
                965                 970                 975     
Pro Arg Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val 
            980                 985                 990         
Glu Arg Leu Trp Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg 
        995                 1000                1005            
Asn Arg Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe 
    1010                1015                1020                
Gln Glu Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu 
1025                1030                1035                1040
Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val 
                1045                1050                1055    
Glu Asp Asn Ile Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr 
            1060                1065                1070        
Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly 
        1075                1080                1085            
Ala Glu Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr 
    1090                1095                1100                
Phe Trp Glu Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp 
1105                1110                1115                1120
Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val 
                1125                1130                1135    
His Ser Gly Leu Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu 
            1140                1145                1150        
Asn Pro Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe 
        1155                1160                1165            
Phe Thr Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met 
    1170                1175                1180                
Glu Arg Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr 
1185                1190                1195                1200
Phe Lys Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Ile Met Asp 
                1205                1210                1215    
Thr Leu Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr 
            1220                1225                1230        
Leu Leu Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser 
        1235                1240                1245            
Gly His Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Leu 
    1250                1255                1260                
Tyr Asn Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser 
1265                1270                1275                1280
Lys Ala Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His 
                1285                1290                1295    
Ala Gly Met Ser Thr Leu Phe Leu Val Tyr Ser Asn Lys Cys Gln Thr 
            1300                1305                1310        
Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe Gln Ile Thr Ala 
        1315                1320                1325            
Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala Arg Leu His Tyr 
    1330                1335                1340                
Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro Phe Ser Trp Ile 
1345                1350                1355                1360
Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly Ile Lys Thr Gln 
                1365                1370                1375    
Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser Gln Phe Ile Ile 
            1380                1385                1390        
Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr Arg Gly Asn Ser 
        1395                1400                1405            
Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp Ser Ser Gly Ile 
    1410                1415                1420                
Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg Tyr Ile Arg Leu 
1425                1430                1435                1440
His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg Met Glu Leu Met 
                1445                1450                1455    
Gly Cys Asp Leu Asn Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys 
            1460                1465                1470        
Ala Ile Ser Asp Ala Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met 
        1475                1480                1485            
Phe Ala Thr Trp Ser Pro Ser Lys Ala Arg Leu His Leu Gln Gly Arg 
    1490                1495                1500                
Ser Asn Ala Trp Arg Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln 
1505                1510                1515                1520
Val Asp Phe Gln Lys Thr Met Lys Val Thr Gly Val Thr Thr Gln Gly 
                1525                1530                1535    
Val Lys Ser Leu Leu Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser 
            1540                1545                1550        
Ser Ser Gln Asp Gly His Gln Trp Thr Leu Phe Phe Gln Asn Gly Lys 
        1555                1560                1565            
Val Lys Val Phe Gln Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn 
    1570                1575                1580                
Ser Leu Asp Pro Pro Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln 
1585                1590                1595                1600
Ser Trp Val His Gln Ile Ala Leu Arg Met Glu Val Leu Gly Cys Glu 
                1605                1610                1615    
Ala Gln Asp Leu Tyr Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe 
            1620                1625                1630        
Ser Gln Asn Ser Arg His Pro Ser Leu Ala Glu Ala Lys Glu Ala Ala 
        1635                1640                1645            
Asn Ala Glu Leu Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu 
    1650                1655                1660                
Ile Asp Lys Ala Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala 
1665                1670                1675                1680
Ile Leu Ala Ala Leu Pro Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                1685                1690                1695    
Ser Gly Ser Gly Ser Lys Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser 
            1700                1705                1710        
Gln Asn Ser Arg His Pro Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        1715                1720                1725            
Gly Ser Gly Ser Leu Ala Glu Ala Lys Glu Ala Ala Asn Ala Glu Leu 
    1730                1735                1740                
Asp Ser Tyr Gly Val Ser Asp Phe Tyr Lys Arg Leu Ile Asp Lys Ala 
1745                1750                1755                1760
Lys Thr Val Glu Gly Val Glu Ala Leu Lys Asp Ala Ile Leu Ala Ala 
                1765                1770                1775    
Leu Pro 
        

<210> 120
<211> 4338
<212> DNA
<213> Artificial Sequence


<220> 
<223> AC-19M_SC

<400> 120
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgcagtcc gaccaggaag agatcgatta cgacgacacc     2340

atcagcgtgg aaatgaagaa agaagatttc gacatctacg acgaggacga gaaccagagc     2400

ccccggtctt tccagaaaaa gacccggcac tacttcattg ccgctgtgga acggctgtgg     2460

gactacggca tgagcagcag ccctcacgtg ctgagaaaca gggcccagag cggcagcgtg     2520

ccccagttca agaaagtggt gttccaggag tttaccgacg gcagcttcac ccagcccctg     2580

tacagaggcg agctgaacga gcatctgggc ctgctgggac cttacatccg ggccgaagtg     2640

gaagataaca tcatggtcac cttccggaat caggcctccc ggccctacag cttctacagc     2700

tccctgatca gctacgaaga ggaccagagg cagggggccg agcccagaaa gaacttcgtg     2760

aagcccaacg agactaagac ctacttctgg gaggtgcagc accacatggc ccctacaaag     2820

gacgaattcg actgcaaggc ctgggcctac ttctccgatg tggatctgga aaaggacgtg     2880

cacagcggcc tgattggacc tctgctcgtg tgtcacacca acaccctgaa ccccgcccac     2940

ggcagacaag tgacagtgca ggaatttgcc ctgttcttca ccatcttcga cgaaacaaag     3000

agctggtact tcaccgaaaa catggaaaga aactgccggg ctccctgcaa catccagatg     3060

gaagatccca ccttcaaaga gaactaccgg ttccacgcca tcaacggcta catcatggac     3120

acactgcccg gcctcgtgat ggctcaggat cagcggatcc ggtggtatct gctgtccatg     3180

ggctccaacg agaacatcca cagcatccac ttcagcggcc acgtgttcac cgtgcggaaa     3240

aaagaagagt acaaaatggc cctgtacaac ctgtaccctg gggtgttcga gacagtggaa     3300

atgctgccca gcaaggccgg catctggcgg gtggaatgtc tgatcgggga gcatctgcac     3360

gctgggatga gcacactgtt tctggtgtac agcgacaagt gccagacacc tctgggcatg     3420

gcctctggcc acatccggga ctttcagatc acagccagcg gccagtatgg ccagtgggcc     3480

cctaaactgg ccagactgca ctacagcggc ggcatcaatg cctggtccac caaagagccc     3540

ttcagctgga tcaaggtgga cctgctggct cccatgatca tccacggaat caagacccag     3600

ggcgccagac agaagttcag cagcctgtac atcagccagt tcatcatcat gtacagcctg     3660

gacggcaaga agtggcagac ctaccggggc aatagcaccg gcaccctgat ggtgttcttc     3720

ggcaacgtgg actcctccgg cattaagcac aacatcttca acccccccat cattgcccgg     3780

tacatccggc tgcaccccac ccactacagc atccggtcca ccctgcggat ggaactgatg     3840

ggctgcgacc tgaacagctg cagcatgccc ctgggaatgg aaagcaaggc catctccgac     3900

gcccagatca ccgcctccag ctacttcacc aacatgttcg ccacctggtc cccatccaag     3960

gcccggctgc atctgcaggg cagaagcaat gcttggaggc cccaagtgaa caaccccaaa     4020

gaatggctgc aggtggactt tcagaaaacc atgaaagtga ccggcgtgac cacccagggc     4080

gtgaaaagcc tgctgacctc tatgtacgtg aaagagttcc tgatctccag cagccaggac     4140

ggccaccagt ggaccctgtt tttccagaac ggcaaagtga aagtgtttca ggggaaccag     4200

gactccttca cccccgtcgt gaacacactg gatcccccac tgctgaccag atacctgcgg     4260

atccaccctc agagctgggc ccaccagatc gctctgagaa tggaagtgct gggatgcgag     4320

gcccaggacc tgtactga                                                   4338


<210> 121
<211> 5337
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD2-19M

<400> 121
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgtccaaa aacaacgcca ttgagcctcg gagcttctcc     2340

cagaactccc ggcatccatc tctggccgag gccaaagaag ccgccaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgaca aggccaagac agtggaaggc     2460

gtggaagctc tgaaggatgc catcctggct gccctgcctg gaagcggagg atctggcggc     2520

tcaggcggat ctggctctgg ctctaaaaac aatgctattg aacctagatc ttttagccag     2580

aacagccggc acccctccgg ctctggcgga agtgggggaa gtggcggctc tggatctctg     2640

gcagaagcta aagaggctgc taacgctgaa ctggactcct atggggtgtc cgatttttac     2700

aaaagactga ttgataaggc taaaactgtg gaaggggtgg aagccctgaa agacgctatt     2760

ctggccgctc tgccttctaa gaacaacgca atcgaaccac gcagcttttc tcagaatagc     2820

agacacccca gccagtccga ccaggaagag atcgattacg acgacaccat cagcgtggaa     2880

atgaagaaag aagatttcga catctacgac gaggacgaga accagagccc ccggtctttc     2940

cagaaaaaga cccggcacta cttcattgcc gctgtggaac ggctgtggga ctacggcatg     3000

agcagcagcc ctcacgtgct gagaaacagg gcccagagcg gcagcgtgcc ccagttcaag     3060

aaagtggtgt tccaggagtt taccgacggc agcttcaccc agcccctgta cagaggcgag     3120

ctgaacgagc atctgggcct gctgggacct tacatccggg ccgaagtgga agataacatc     3180

atggtcacct tccggaatca ggcctcccgg ccctacagct tctacagctc cctgatcagc     3240

tacgaagagg accagaggca gggggccgag cccagaaaga acttcgtgaa gcccaacgag     3300

actaagacct acttctggga ggtgcagcac cacatggccc ctacaaagga cgaattcgac     3360

tgcaaggcct gggcctactt ctccgatgtg gatctggaaa aggacgtgca cagcggcctg     3420

attggacctc tgctcgtgtg tcacaccaac accctgaacc ccgcccacgg cagacaagtg     3480

acagtgcagg aatttgccct gttcttcacc atcttcgacg aaacaaagag ctggtacttc     3540

accgaaaaca tggaaagaaa ctgccgggct ccctgcaaca tccagatgga agatcccacc     3600

ttcaaagaga actaccggtt ccacgccatc aacggctaca tcatggacac actgcccggc     3660

ctcgtgatgg ctcaggatca gcggatccgg tggtatctgc tgtccatggg ctccaacgag     3720

aacatccaca gcatccactt cagcggccac gtgttcaccg tgcggaaaaa agaagagtac     3780

aaaatggccc tgtacaacct gtaccctggg gtgttcgaga cagtggaaat gctgcccagc     3840

aaggccggca tctggcgggt ggaatgtctg atcggggagc atctgcacgc tgggatgagc     3900

acactgtttc tggtgtacag cgacaagtgc cagacacctc tgggcatggc ctctggccac     3960

atccgggact ttcagatcac agccagcggc cagtatggcc agtgggcccc taaactggcc     4020

agactgcact acagcggcgg catcaatgcc tggtccacca aagagccctt cagctggatc     4080

aaggtggacc tgctggctcc catgatcatc cacggaatca agacccaggg cgccagacag     4140

aagttcagca gcctgtacat cagccagttc atcatcatgt acagcctgga cggcaagaag     4200

tggcagacct accggggcaa tagcaccggc accctgatgg tgttcttcgg caacgtggac     4260

tcctccggca ttaagcacaa catcttcaac ccccccatca ttgcccggta catccggctg     4320

caccccaccc actacagcat ccggtccacc ctgcggatgg aactgatggg ctgcgacctg     4380

aacagctgca gcatgcccct gggaatggaa agcaaggcca tctccgacgc ccagatcacc     4440

gcctccagct acttcaccaa catgttcgcc acctggtccc catccaaggc ccggctgcat     4500

ctgcagggca gaagcaatgc ttggaggccc caagtgaaca accccaaaga atggctgcag     4560

gtggactttc agaaaaccat gaaagtgacc ggcgtgacca cccagggcgt gaaaagcctg     4620

ctgacctcta tgtacgtgaa agagttcctg atctccagca gccaggacgg ccaccagtgg     4680

accctgtttt tccagaacgg caaagtgaaa gtgtttcagg ggaaccagga ctccttcacc     4740

cccgtcgtga acacactgga tcccccactg ctgaccagat acctgcggat ccaccctcag     4800

agctgggccc accagatcgc tctgagaatg gaagtgctgg gatgcgaggc ccaggacctg     4860

tacagcaaga acaacgctat tgagccacgc tcattcagcc agaactccag gcaccctagc     4920

ctggctgagg caaaagaggc agcaaacgca gagctggatt cttatggcgt gtcagatttc     4980

tataagcgcc tgattgacaa agcaaaaacc gtggaaggcg tggaagcact gaaggacgca     5040

attctggcag ccctgccagg cagtggcgga tcagggggca gcggaggaag cggaagcggc     5100

tcaaagaaca atgcaattga gccaagaagt ttctctcaga acagtaggca cccaagcggc     5160

tccgggggaa gcgggggctc agggggctcc ggaagcctgg cagaagccaa agaagcagca     5220

aacgccgaac tggacagtta tggggtgtca gacttctaca agagactgat tgataaggca     5280

aagaccgtgg aaggcgtgga agccctgaaa gacgccatcc tggcagcact gccatga        5337


<210> 122
<211> 4785
<212> DNA
<213> Artificial Sequence


<220> 
<223> ALDLCLD-19M_SC

<400> 122
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgtccaaa aacaacgcca ttgagcctcg gagcttctcc     2340

cagaactccc ggcatccatc tctggccgag gccaaagaag ccgccaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgaca aggccaagac agtggaaggc     2460

gtggaagctc tgaaggatgc catcctggct gccctgcctt ctaagaacaa cgcaatcgaa     2520

ccacgcagct tttctcagaa tagcagacac cccagccagt ccgaccagga agagatcgat     2580

tacgacgaca ccatcagcgt ggaaatgaag aaagaagatt tcgacatcta cgacgaggac     2640

gagaaccaga gcccccggtc tttccagaaa aagacccggc actacttcat tgccgctgtg     2700

gaacggctgt gggactacgg catgagcagc agccctcacg tgctgagaaa cagggcccag     2760

agcggcagcg tgccccagtt caagaaagtg gtgttccagg agtttaccga cggcagcttc     2820

acccagcccc tgtacagagg cgagctgaac gagcatctgg gcctgctggg accttacatc     2880

cgggccgaag tggaagataa catcatggtc accttccgga atcaggcctc ccggccctac     2940

agcttctaca gctccctgat cagctacgaa gaggaccaga ggcagggggc cgagcccaga     3000

aagaacttcg tgaagcccaa cgagactaag acctacttct gggaggtgca gcaccacatg     3060

gcccctacaa aggacgaatt cgactgcaag gcctgggcct acttctccga tgtggatctg     3120

gaaaaggacg tgcacagcgg cctgattgga cctctgctcg tgtgtcacac caacaccctg     3180

aaccccgccc acggcagaca agtgacagtg caggaatttg ccctgttctt caccatcttc     3240

gacgaaacaa agagctggta cttcaccgaa aacatggaaa gaaactgccg ggctccctgc     3300

aacatccaga tggaagatcc caccttcaaa gagaactacc ggttccacgc catcaacggc     3360

tacatcatgg acacactgcc cggcctcgtg atggctcagg atcagcggat ccggtggtat     3420

ctgctgtcca tgggctccaa cgagaacatc cacagcatcc acttcagcgg ccacgtgttc     3480

accgtgcgga aaaaagaaga gtacaaaatg gccctgtaca acctgtaccc tggggtgttc     3540

gagacagtgg aaatgctgcc cagcaaggcc ggcatctggc gggtggaatg tctgatcggg     3600

gagcatctgc acgctgggat gagcacactg tttctggtgt acagcgacaa gtgccagaca     3660

cctctgggca tggcctctgg ccacatccgg gactttcaga tcacagccag cggccagtat     3720

ggccagtggg cccctaaact ggccagactg cactacagcg gcggcatcaa tgcctggtcc     3780

accaaagagc ccttcagctg gatcaaggtg gacctgctgg ctcccatgat catccacgga     3840

atcaagaccc agggcgccag acagaagttc agcagcctgt acatcagcca gttcatcatc     3900

atgtacagcc tggacggcaa gaagtggcag acctaccggg gcaatagcac cggcaccctg     3960

atggtgttct tcggcaacgt ggactcctcc ggcattaagc acaacatctt caaccccccc     4020

atcattgccc ggtacatccg gctgcacccc acccactaca gcatccggtc caccctgcgg     4080

atggaactga tgggctgcga cctgaacagc tgcagcatgc ccctgggaat ggaaagcaag     4140

gccatctccg acgcccagat caccgcctcc agctacttca ccaacatgtt cgccacctgg     4200

tccccatcca aggcccggct gcatctgcag ggcagaagca atgcttggag gccccaagtg     4260

aacaacccca aagaatggct gcaggtggac tttcagaaaa ccatgaaagt gaccggcgtg     4320

accacccagg gcgtgaaaag cctgctgacc tctatgtacg tgaaagagtt cctgatctcc     4380

agcagccagg acggccacca gtggaccctg tttttccaga acggcaaagt gaaagtgttt     4440

caggggaacc aggactcctt cacccccgtc gtgaacacac tggatccccc actgctgacc     4500

agatacctgc ggatccaccc tcagagctgg gcccaccaga tcgctctgag aatggaagtg     4560

ctgggatgcg aggcccagga cctgtacagc aagaacaacg ctattgagcc acgctcattc     4620

agccagaact ccaggcaccc tagcctggct gaggcaaaag aggcagcaaa cgcagagctg     4680

gattcttatg gcgtgtcaga tttctataag cgcctgattg acaaagcaaa aaccgtggaa     4740

ggcgtggaag cactgaagga cgcaattctg gcagccctgc catga                     4785


<210> 123
<211> 4728
<212> DNA
<213> Artificial Sequence


<220> 
<223> ADLCLD-19M_SC-V1

<400> 123
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgctggcc gaggccaaag aagccgccaa cgccgagctg     2340

gatagctacg gcgtgtccga cttctacaag cggctgatcg acaaggccaa gacagtggaa     2400

ggcgtggaag ctctgaagga tgccatcctg gctgccctgc cttctaagaa caacgcaatc     2460

gaaccacgca gcttttctca gaatagcaga caccccagcc agtccgacca ggaagagatc     2520

gattacgacg acaccatcag cgtggaaatg aagaaagaag atttcgacat ctacgacgag     2580

gacgagaacc agagcccccg gtctttccag aaaaagaccc ggcactactt cattgccgct     2640

gtggaacggc tgtgggacta cggcatgagc agcagccctc acgtgctgag aaacagggcc     2700

cagagcggca gcgtgcccca gttcaagaaa gtggtgttcc aggagtttac cgacggcagc     2760

ttcacccagc ccctgtacag aggcgagctg aacgagcatc tgggcctgct gggaccttac     2820

atccgggccg aagtggaaga taacatcatg gtcaccttcc ggaatcaggc ctcccggccc     2880

tacagcttct acagctccct gatcagctac gaagaggacc agaggcaggg ggccgagccc     2940

agaaagaact tcgtgaagcc caacgagact aagacctact tctgggaggt gcagcaccac     3000

atggccccta caaaggacga attcgactgc aaggcctggg cctacttctc cgatgtggat     3060

ctggaaaagg acgtgcacag cggcctgatt ggacctctgc tcgtgtgtca caccaacacc     3120

ctgaaccccg cccacggcag acaagtgaca gtgcaggaat ttgccctgtt cttcaccatc     3180

ttcgacgaaa caaagagctg gtacttcacc gaaaacatgg aaagaaactg ccgggctccc     3240

tgcaacatcc agatggaaga tcccaccttc aaagagaact accggttcca cgccatcaac     3300

ggctacatca tggacacact gcccggcctc gtgatggctc aggatcagcg gatccggtgg     3360

tatctgctgt ccatgggctc caacgagaac atccacagca tccacttcag cggccacgtg     3420

ttcaccgtgc ggaaaaaaga agagtacaaa atggccctgt acaacctgta ccctggggtg     3480

ttcgagacag tggaaatgct gcccagcaag gccggcatct ggcgggtgga atgtctgatc     3540

ggggagcatc tgcacgctgg gatgagcaca ctgtttctgg tgtacagcga caagtgccag     3600

acacctctgg gcatggcctc tggccacatc cgggactttc agatcacagc cagcggccag     3660

tatggccagt gggcccctaa actggccaga ctgcactaca gcggcggcat caatgcctgg     3720

tccaccaaag agcccttcag ctggatcaag gtggacctgc tggctcccat gatcatccac     3780

ggaatcaaga cccagggcgc cagacagaag ttcagcagcc tgtacatcag ccagttcatc     3840

atcatgtaca gcctggacgg caagaagtgg cagacctacc ggggcaatag caccggcacc     3900

ctgatggtgt tcttcggcaa cgtggactcc tccggcatta agcacaacat cttcaacccc     3960

cccatcattg cccggtacat ccggctgcac cccacccact acagcatccg gtccaccctg     4020

cggatggaac tgatgggctg cgacctgaac agctgcagca tgcccctggg aatggaaagc     4080

aaggccatct ccgacgccca gatcaccgcc tccagctact tcaccaacat gttcgccacc     4140

tggtccccat ccaaggcccg gctgcatctg cagggcagaa gcaatgcttg gaggccccaa     4200

gtgaacaacc ccaaagaatg gctgcaggtg gactttcaga aaaccatgaa agtgaccggc     4260

gtgaccaccc agggcgtgaa aagcctgctg acctctatgt acgtgaaaga gttcctgatc     4320

tccagcagcc aggacggcca ccagtggacc ctgtttttcc agaacggcaa agtgaaagtg     4380

tttcagggga accaggactc cttcaccccc gtcgtgaaca cactggatcc cccactgctg     4440

accagatacc tgcggatcca ccctcagagc tgggcccacc agatcgctct gagaatggaa     4500

gtgctgggat gcgaggccca ggacctgtac agcaagaaca acgctattga gccacgctca     4560

ttcagccaga actccaggca ccctagcctg gctgaggcaa aagaggcagc aaacgcagag     4620

ctggattctt atggcgtgtc agatttctat aagcgcctga ttgacaaagc aaaaaccgtg     4680

gaaggcgtgg aagcactgaa ggacgcaatt ctggcagccc tgccatga                  4728


<210> 124
<211> 4728
<212> DNA
<213> Artificial Sequence


<220> 
<223> ADLCLD-19M_SC-V2

<400> 124
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctggccgag gccaaagaag ccgccaacgc cgagctggat     2340

agctacggcg tgtccgactt ctacaagcgg ctgatcgaca aggccaagac agtggaaggc     2400

gtggaagctc tgaaggatgc catcctggct gccctgcctt ctaagaacaa cgcaatcgaa     2460

ccacgcagct tttctcagaa tagcagacac cccagcctgc agtccgacca ggaagagatc     2520

gattacgacg acaccatcag cgtggaaatg aagaaagaag atttcgacat ctacgacgag     2580

gacgagaacc agagcccccg gtctttccag aaaaagaccc ggcactactt cattgccgct     2640

gtggaacggc tgtgggacta cggcatgagc agcagccctc acgtgctgag aaacagggcc     2700

cagagcggca gcgtgcccca gttcaagaaa gtggtgttcc aggagtttac cgacggcagc     2760

ttcacccagc ccctgtacag aggcgagctg aacgagcatc tgggcctgct gggaccttac     2820

atccgggccg aagtggaaga taacatcatg gtcaccttcc ggaatcaggc ctcccggccc     2880

tacagcttct acagctccct gatcagctac gaagaggacc agaggcaggg ggccgagccc     2940

agaaagaact tcgtgaagcc caacgagact aagacctact tctgggaggt gcagcaccac     3000

atggccccta caaaggacga attcgactgc aaggcctggg cctacttctc cgatgtggat     3060

ctggaaaagg acgtgcacag cggcctgatt ggacctctgc tcgtgtgtca caccaacacc     3120

ctgaaccccg cccacggcag acaagtgaca gtgcaggaat ttgccctgtt cttcaccatc     3180

ttcgacgaaa caaagagctg gtacttcacc gaaaacatgg aaagaaactg ccgggctccc     3240

tgcaacatcc agatggaaga tcccaccttc aaagagaact accggttcca cgccatcaac     3300

ggctacatca tggacacact gcccggcctc gtgatggctc aggatcagcg gatccggtgg     3360

tatctgctgt ccatgggctc caacgagaac atccacagca tccacttcag cggccacgtg     3420

ttcaccgtgc ggaaaaaaga agagtacaaa atggccctgt acaacctgta ccctggggtg     3480

ttcgagacag tggaaatgct gcccagcaag gccggcatct ggcgggtgga atgtctgatc     3540

ggggagcatc tgcacgctgg gatgagcaca ctgtttctgg tgtacagcga caagtgccag     3600

acacctctgg gcatggcctc tggccacatc cgggactttc agatcacagc cagcggccag     3660

tatggccagt gggcccctaa actggccaga ctgcactaca gcggcggcat caatgcctgg     3720

tccaccaaag agcccttcag ctggatcaag gtggacctgc tggctcccat gatcatccac     3780

ggaatcaaga cccagggcgc cagacagaag ttcagcagcc tgtacatcag ccagttcatc     3840

atcatgtaca gcctggacgg caagaagtgg cagacctacc ggggcaatag caccggcacc     3900

ctgatggtgt tcttcggcaa cgtggactcc tccggcatta agcacaacat cttcaacccc     3960

cccatcattg cccggtacat ccggctgcac cccacccact acagcatccg gtccaccctg     4020

cggatggaac tgatgggctg cgacctgaac agctgcagca tgcccctggg aatggaaagc     4080

aaggccatct ccgacgccca gatcaccgcc tccagctact tcaccaacat gttcgccacc     4140

tggtccccat ccaaggcccg gctgcatctg cagggcagaa gcaatgcttg gaggccccaa     4200

gtgaacaacc ccaaagaatg gctgcaggtg gactttcaga aaaccatgaa agtgaccggc     4260

gtgaccaccc agggcgtgaa aagcctgctg acctctatgt acgtgaaaga gttcctgatc     4320

tccagcagcc aggacggcca ccagtggacc ctgtttttcc agaacggcaa agtgaaagtg     4380

tttcagggga accaggactc cttcaccccc gtcgtgaaca cactggatcc cccactgctg     4440

accagatacc tgcggatcca ccctcagagc tgggcccacc agatcgctct gagaatggaa     4500

gtgctgggat gcgaggccca ggacctgtac agcaagaaca acgctattga gccacgctca     4560

ttcagccaga actccaggca ccctagcctg gctgaggcaa aagaggcagc aaacgcagag     4620

ctggattctt atggcgtgtc agatttctat aagcgcctga ttgacaaagc aaaaaccgtg     4680

gaaggcgtgg aagcactgaa ggacgcaatt ctggcagccc tgccatga                  4728


<210> 125
<211> 5061
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD-19M_SC

<400> 125
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgtccaaa aacaacgcca ttgagcctcg gagcttctcc     2340

cagaactccc ggcatccatc tctggccgag gccaaagaag ccgccaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgaca aggccaagac agtggaaggc     2460

gtggaagctc tgaaggatgc catcctggct gccctgcctg gaagcggagg atctggcggc     2520

tcaggcggat ctggctctgg ctctaaaaac aatgctattg aacctagatc ttttagccag     2580

aacagccggc acccctccgg ctctggcgga agtgggggaa gtggcggctc tggatctctg     2640

gcagaagcta aagaggctgc taacgctgaa ctggactcct atggggtgtc cgatttttac     2700

aaaagactga ttgataaggc taaaactgtg gaaggggtgg aagccctgaa agacgctatt     2760

ctggccgctc tgccttctaa gaacaacgca atcgaaccac gcagcttttc tcagaatagc     2820

agacacccca gccagtccga ccaggaagag atcgattacg acgacaccat cagcgtggaa     2880

atgaagaaag aagatttcga catctacgac gaggacgaga accagagccc ccggtctttc     2940

cagaaaaaga cccggcacta cttcattgcc gctgtggaac ggctgtggga ctacggcatg     3000

agcagcagcc ctcacgtgct gagaaacagg gcccagagcg gcagcgtgcc ccagttcaag     3060

aaagtggtgt tccaggagtt taccgacggc agcttcaccc agcccctgta cagaggcgag     3120

ctgaacgagc atctgggcct gctgggacct tacatccggg ccgaagtgga agataacatc     3180

atggtcacct tccggaatca ggcctcccgg ccctacagct tctacagctc cctgatcagc     3240

tacgaagagg accagaggca gggggccgag cccagaaaga acttcgtgaa gcccaacgag     3300

actaagacct acttctggga ggtgcagcac cacatggccc ctacaaagga cgaattcgac     3360

tgcaaggcct gggcctactt ctccgatgtg gatctggaaa aggacgtgca cagcggcctg     3420

attggacctc tgctcgtgtg tcacaccaac accctgaacc ccgcccacgg cagacaagtg     3480

acagtgcagg aatttgccct gttcttcacc atcttcgacg aaacaaagag ctggtacttc     3540

accgaaaaca tggaaagaaa ctgccgggct ccctgcaaca tccagatgga agatcccacc     3600

ttcaaagaga actaccggtt ccacgccatc aacggctaca tcatggacac actgcccggc     3660

ctcgtgatgg ctcaggatca gcggatccgg tggtatctgc tgtccatggg ctccaacgag     3720

aacatccaca gcatccactt cagcggccac gtgttcaccg tgcggaaaaa agaagagtac     3780

aaaatggccc tgtacaacct gtaccctggg gtgttcgaga cagtggaaat gctgcccagc     3840

aaggccggca tctggcgggt ggaatgtctg atcggggagc atctgcacgc tgggatgagc     3900

acactgtttc tggtgtacag cgacaagtgc cagacacctc tgggcatggc ctctggccac     3960

atccgggact ttcagatcac agccagcggc cagtatggcc agtgggcccc taaactggcc     4020

agactgcact acagcggcgg catcaatgcc tggtccacca aagagccctt cagctggatc     4080

aaggtggacc tgctggctcc catgatcatc cacggaatca agacccaggg cgccagacag     4140

aagttcagca gcctgtacat cagccagttc atcatcatgt acagcctgga cggcaagaag     4200

tggcagacct accggggcaa tagcaccggc accctgatgg tgttcttcgg caacgtggac     4260

tcctccggca ttaagcacaa catcttcaac ccccccatca ttgcccggta catccggctg     4320

caccccaccc actacagcat ccggtccacc ctgcggatgg aactgatggg ctgcgacctg     4380

aacagctgca gcatgcccct gggaatggaa agcaaggcca tctccgacgc ccagatcacc     4440

gcctccagct acttcaccaa catgttcgcc acctggtccc catccaaggc ccggctgcat     4500

ctgcagggca gaagcaatgc ttggaggccc caagtgaaca accccaaaga atggctgcag     4560

gtggactttc agaaaaccat gaaagtgacc ggcgtgacca cccagggcgt gaaaagcctg     4620

ctgacctcta tgtacgtgaa agagttcctg atctccagca gccaggacgg ccaccagtgg     4680

accctgtttt tccagaacgg caaagtgaaa gtgtttcagg ggaaccagga ctccttcacc     4740

cccgtcgtga acacactgga tcccccactg ctgaccagat acctgcggat ccaccctcag     4800

agctgggccc accagatcgc tctgagaatg gaagtgctgg gatgcgaggc ccaggacctg     4860

tacagcaaga acaacgctat tgagccacgc tcattcagcc agaactccag gcaccctagc     4920

ctggctgagg caaaagaggc agcaaacgca gagctggatt cttatggcgt gtcagatttc     4980

tataagcgcc tgattgacaa agcaaaaacc gtggaaggcg tggaagcact gaaggacgca     5040

attctggcag ccctgccatg a                                               5061


<210> 126
<211> 5337
<212> DNA
<213> Artificial Sequence


<220> 
<223> AD2CD2-15M_SC

<400> 126
atgcagatcg agctgtctac ctgcttcttc ctgtgcctgc tgcggttctg cttcagcgcc       60

accagacggt actatctggg cgccgtggaa ctgagctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggatgc cagattccct ccaagagtgc ccaagagctt ccccttcaac      180

acctccgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttctctatc      240

gccaagccca gacccccctg gatgggactg ctgggcccta caattcaggc cgaggtgtac      300

gacaccgtcg tgatcaccct gaagaacatg gccacccacc ccgtgtctct gcatgccgtg      360

ggagtgtcct actggaaggc ctctgagggc gccgagtacg acgatcagac cagccagcgc      420

gagaaagagg acgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgtcc      480

aaagaaaacg gccccatggc cagcgacccc cagtgtctga catacagcta cctgagccac      540

gtggacctgg ccaaggacct gaactctggc ctgatcggag ccctgctcgt gtgcagagaa      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaaggaca gcctgatgca ggacagggac      720

gccgcctctg ctagagcctg gcccaaaatg cacaccgtga acggctacgt gaacagaagc      780

ctgcctggcc tgaccggctg ccacagaaag tccgtgtact ggcacgtgat cggcatgggt      840

accacccccg aggtgcacag catctttctg gaaggacaca cctttctcgt gcgggaccac      900

agacaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agtttctgct gttctgccac atcagctccc accagcacga cggcatggaa     1020

gcctacgtga aggtggacag ctgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcgcttcgac     1140

gacgataaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggatt acgcccctct ggtgctggcc     1260

cccgacgaca gatctcacaa gagccagtac ctgaacaacg gcccccagcg gatcggccgg     1320

aagtataaga aagtgcggtt catggcctac accgacgaga cattcaagac cagagaggcc     1380

atccagcacg agagcggcat cctgggccct ctgctgtatg gcgaagtggg cgacaccctg     1440

ctgatcatct tcaagaacca ggccagcaga ccctacaaca tctaccctca cggcatcacc     1500

gacgtgcggc ccctgtatga gagaaggctg cccaagggcg tgaagcacct gaaggacttc     1560

cctatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga agatggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gccacgtgaa catggaacgg     1680

gatctggcca gcggactgat cggcccactg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgtttagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaatatc cagcggttcc tgcccgaacc tgccggcgtg     1860

cagctggaag atcctgagtt ccaggcctcc aacatcatgc actccatcaa tggctatgtg     1920

ttcgacagcc tgcagctgag cgtgtgcctg cacgaggtgg cctactggta catcctgagc     1980

atcggggccc agaccgactt cctgtccgtg ttcttctccg gctacacctt caagcacaag     2040

atggtgtacg aggataccct gaccctgttc ccctttagcg gcgaaaccgt gttcatgagc     2100

atggaaaacc ccggcaactg gatcctgggc tgtcacaaca gcgacttccg gaacagaggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctatgagg atatcagcgc cagcctgctg agcaagaaca atgccatcga gccccggtcc     2280

ttcagccaga accctcctgt gctgtccaaa aacaacgcca ttgagcctcg gagcttctcc     2340

cagaactccc ggcatccatc tctggccgag gccaaagaag ccgccaacgc cgagctggat     2400

agctacggcg tgtccgactt ctacaagcgg ctgatcgaca aggccaagac agtggaaggc     2460

gtggaagctc tgaaggatgc catcctggct gccctgcctg gaagcggagg atctggcggc     2520

tcaggcggat ctggctctgg ctctaaaaac aatgctattg aacctagatc ttttagccag     2580

aacagccggc acccctccgg ctctggcgga agtgggggaa gtggcggctc tggatctctg     2640

gcagaagcta aagaggctgc taacgctgaa ctggactcct atggggtgtc cgatttttac     2700

aaaagactga ttgataaggc taaaactgtg gaaggggtgg aagccctgaa agacgctatt     2760

ctggccgctc tgccttctaa gaacaacgca atcgaaccac gcagcttttc tcagaatagc     2820

agacacccca gccagtccga ccaggaagag atcgattacg acgacaccat cagcgtggaa     2880

atgaagaaag aagatttcga catctacgac gaggacgaga accagagccc ccggtctttc     2940

cagaaaaaga cccggcacta cttcattgcc gctgtggaac ggctgtggga ctacggcatg     3000

agcagcagcc ctcacgtgct gagaaacagg gcccagagcg gcagcgtgcc ccagttcaag     3060

aaagtggtgt tccaggagtt taccgacggc agcttcaccc agcccctgta cagaggcgag     3120

ctgaacgagc atctgggcct gctgggacct tacatccggg ccgaagtgga agataacatc     3180

atggtcacct tccggaatca ggcctcccgg ccctacagct tctacagctc cctgatcagc     3240

tacgaagagg accagaggca gggggccgag cccagaaaga acttcgtgaa gcccaacgag     3300

actaagacct acttctggga ggtgcagcac cacatggccc ctacaaagga cgaattcgac     3360

tgcaaggcct gggcctactt ctccgatgtg gatctggaaa aggacgtgca cagcggcctg     3420

attggacctc tgctcgtgtg tcacaccaac accctgaacc ccgcccacgg cagacaagtg     3480

acagtgcagg aatttgccct gttcttcacc atcttcgacg aaacaaagag ctggtacttc     3540

accgaaaaca tggaaagaaa ctgccgggct ccctgcaaca tccagatgga agatcccacc     3600

ttcaaagaga actaccggtt ccacgccatc aacggctaca tcatggacac actgcccggc     3660

ctcgtgatgg ctcaggatca gcggatccgg tggtatctgc tgtccatggg ctccaacgag     3720

aacatccaca gcatccactt cagcggccac gtgttcaccg tgcggaaaaa agaagagtac     3780

aaaatggccc tgtacaacct gtaccctggg gtgttcgaga cagtggaaat gctgcccagc     3840

aaggccggca tctggcgggt ggaatgtctg atcggggagc atctgcacgc tgggatgagc     3900

acactgtttc tggtgtacag caacaagtgc cagacacctc tgggcatggc ctctggccac     3960

atccgggact ttcagatcac agccagcggc cagtatggcc agtgggcccc taaactggcc     4020

agactgcact acagcggcag catcaatgcc tggtccacca aagagccctt cagctggatc     4080

aaggtggacc tgctggctcc catgatcatc cacggaatca agacccaggg cgccagacag     4140

aagttcagca gcctgtacat cagccagttc atcatcatgt acagcctgga cggcaagaag     4200

tggcagacct accggggcaa tagcaccggc accctgatgg tgttcttcgg caacgtggac     4260

tcctccggca ttaagcacaa catcttcaac ccccccatca ttgcccggta catccggctg     4320

caccccaccc actacagcat ccggtccacc ctgcggatgg aactgatggg ctgcgacctg     4380

aacagctgca gcatgcccct gggaatggaa agcaaggcca tctccgacgc ccagatcacc     4440

gcctccagct acttcaccaa catgttcgcc acctggtccc catccaaggc ccggctgcat     4500

ctgcagggca gaagcaatgc ttggaggccc caagtgaaca accccaaaga atggctgcag     4560

gtggactttc agaaaaccat gaaagtgacc ggcgtgacca cccagggcgt gaaaagcctg     4620

ctgacctcta tgtacgtgaa agagttcctg atctccagca gccaggacgg ccaccagtgg     4680

accctgtttt tccagaacgg caaagtgaaa gtgtttcagg ggaaccagga ctccttcacc     4740

cccgtcgtga acagcctgga tcccccactg ctgaccagat acctgcggat ccaccctcag     4800

agctgggtgc accagatcgc tctgagaatg gaagtgctgg gatgcgaggc ccaggacctg     4860

tacagcaaga acaacgctat tgagccacgc tcattcagcc agaactccag gcaccctagc     4920

ctggctgagg caaaagaggc agcaaacgca gagctggatt cttatggcgt gtcagatttc     4980

tataagcgcc tgattgacaa agcaaaaacc gtggaaggcg tggaagcact gaaggacgca     5040

attctggcag ccctgccagg cagtggcgga tcagggggca gcggaggaag cggaagcggc     5100

tcaaagaaca atgcaattga gccaagaagt ttctctcaga acagtaggca cccaagcggc     5160

tccgggggaa gcgggggctc agggggctcc ggaagcctgg cagaagccaa agaagcagca     5220

aacgccgaac tggacagtta tggggtgtca gacttctaca agagactgat tgataaggca     5280

aagaccgtgg aaggcgtgga agccctgaaa gacgccatcc tggcagcact gccatga        5337


<210> 127
<211> 447
<212> PRT
<213> Homo sapiens


<220> 
<223> Vorhyaluronidase alfa

<400> 127
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp 
1               5                   10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro 
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala 
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr 
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro 
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile 
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp 
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val 
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu 
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala 
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg 
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His 
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile 
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu 
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr 
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile 
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val 
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr 
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp 
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp 
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu 
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys 
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp 
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly 
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys 
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp 
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala 
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr 
        435                 440                 445         

