﻿                         序列表

<110>  北京康普美特创新医药科技有限责任公司

<120>  一种抗补体C5分子的全人源单克隆抗体及应用

<160>  8

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Glu Asp Asp Ala Glu His 
                85                  90                  95      
Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210>  2
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  2
atggccagct acgaactgac ccagccgccg agcgtgtcgg tggcgccggg tcagaccgcg        60
cgtatcacct gctcgggcga tgcgctgggc gataaatacg cgagctggta tcagcagaaa       120
ccgggtcagg caccggtgct ggtgatttac gaagattcta aacgcccgtc tggcatcccg       180
gaacgcttta gcggctcgaa ttcgggcaac accgcgaccc tgaccattag cggcacccag       240
gcggaggatg aggcggacta ttactgctcg gcgtgggagg acgacgctga gcatcaggtg       300
tttggcggtg gcaccaaact gaccgtgctg                                        330

<210>  3
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  3
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      
Thr Val Ala Pro Thr Glu Cys Ser Glx 
            100                 105 

<210>  4
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  4
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa        60
gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg       120
gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa       180
caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag       240
tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg       300
gcccctacag aatgttcata g                                                 321

<210>  5
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Pro Phe Tyr Val Gly Val Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 

<210>  6
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  6
gaagtgcaat tggtggaaag cggtggcggt ctggtgcagc cgggtggcag cctgcgtctg        60
agctgcgcag cgagcggctt cacctttagc agctacgcga tgagctgggt gcgccaggca       120
ccgggtaaag gtctggaatg ggtgagcgcg attagcggta gcggcggcag cacctactat       180
gcggatagcg tgaaaggccg ttttaccatc tcgcgtgata actcgaaaaa caccctgtac       240
ctgcagatga acagcctgcg tgcggaagat accgcggtgt attattgcgc acgtcattat       300
cctggtccgt atgctttcga tgtctggggt cagggcactc tggtgaccgt gtcgagcgcg       360

<210>  7
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  7
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
1               5                   10                  15      
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
65                  70                  75                  80  
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            100                 105                 110         
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
145                 150                 155                 160 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            180                 185                 190         
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        195                 200                 205             
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    210                 215                 220                 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
225                 230                 235                 240 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 

<210>  8
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  8
agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc        60
acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg       120
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga       180
ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac       240
atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa       300
tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg       360
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag       420
gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac       480
gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc       540
acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag       600
tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa       660
gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg       720
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc       780
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg       840
gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag       900
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag       960
aagagcctct ccctgtcccc gggtaaatga                                        990

