                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  Combination of Retromer Phamacological Chaperones and Exogenous 
       Retromer for the Treatment of Alzheimer's Disease and Other 
       Neurodegenerative Diseases or Disorders

<130>  01001/008444-WO0

<140>  Filed Herewith
<141>  2021-02-16

<150>  62/976,496
<151>  2020-02-14

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu 
1               5                   10                  15      


Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg 
            20                  25                  30          


Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys His Ala Ser Asn 
        35                  40                  45              


Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro Lys Ser Tyr Tyr 
    50                  55                  60                  


Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr Leu Glu Val Tyr 
65                  70                  75                  80  


Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu 
                85                  90                  95      


Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile 
            100                 105                 110         


Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln Ser Arg Lys Asp 
        115                 120                 125             


Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu 
    130                 135                 140                 


Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile 
145                 150                 155                 160 


Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Gly Asp Ile 
                165                 170                 175     


Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys 
            180                 185                 190         


Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg Asp Arg Glu Lys 
        195                 200                 205             


Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr Asn Leu 
    210                 215                 220                 


Val Arg Leu Ser Gln Leu Glu Gly Val Asn Val Glu Arg Tyr Lys Gln 
225                 230                 235                 240 


Ile Val Leu Thr Gly Ile Leu Glu Gln Val Val Asn Cys Arg Asp Ala 
                245                 250                 255     


Leu Ala Gln Glu Tyr Leu Met Glu Cys Ile Ile Gln Val Phe Pro Asp 
            260                 265                 270         


Glu Phe His Leu Gln Thr Leu Asn Pro Phe Leu Arg Ala Cys Ala Glu 
        275                 280                 285             


Leu His Gln Asn Val Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp 
    290                 295                 300                 


Arg Leu Ala Leu Phe Ala His Arg Glu Asp Gly Pro Gly Ile Pro Ala 
305                 310                 315                 320 


Asp Ile Lys Leu Phe Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile 
                325                 330                 335     


Gln Ser Arg Gln Asp Met Pro Ser Glu Asp Val Val Ser Leu Gln Val 
            340                 345                 350         


Ser Leu Ile Asn Leu Ala Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr 
        355                 360                 365             


Val Asp Lys Val Leu Glu Thr Thr Val Glu Ile Phe Asn Lys Leu Asn 
    370                 375                 380                 


Leu Glu His Ile Ala Thr Ser Ser Ala Val Ser Lys Glu Leu Thr Arg 
385                 390                 395                 400 


Leu Leu Lys Ile Pro Val Asp Thr Tyr Asn Asn Ile Leu Thr Val Leu 
                405                 410                 415     


Lys Leu Lys His Phe His Pro Leu Phe Glu Tyr Phe Asp Tyr Glu Ser 
            420                 425                 430         


Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Asn Val Leu Asp Tyr Asn 
        435                 440                 445             


Thr Glu Ile Val Ser Gln Asp Gln Val Asp Ser Ile Met Asn Leu Val 
    450                 455                 460                 


Ser Thr Leu Ile Gln Asp Gln Pro Asp Gln Pro Val Glu Asp Pro Asp 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Asp Glu Gln Ser Leu Val Gly Arg Phe Ile His 
                485                 490                 495     


Leu Leu Arg Ser Glu Asp Pro Asp Gln Gln Tyr Leu Ile Leu Asn Thr 
            500                 505                 510         


Ala Arg Lys His Phe Gly Ala Gly Gly Asn Gln Arg Ile Arg Phe Thr 
        515                 520                 525             


Leu Pro Pro Leu Val Phe Ala Ala Tyr Gln Leu Ala Phe Arg Tyr Lys 
    530                 535                 540                 


Glu Asn Ser Lys Val Asp Asp Lys Trp Glu Lys Lys Cys Gln Lys Ile 
545                 550                 555                 560 


Phe Ser Phe Ala His Gln Thr Ile Ser Ala Leu Ile Lys Ala Glu Leu 
                565                 570                 575     


Ala Glu Leu Pro Leu Arg Leu Phe Leu Gln Gly Ala Leu Ala Ala Gly 
            580                 585                 590         


Glu Ile Gly Phe Glu Asn His Glu Thr Val Ala Tyr Glu Phe Met Ser 
        595                 600                 605             


Gln Ala Phe Ser Leu Tyr Glu Asp Glu Ile Ser Asp Ser Lys Ala Gln 
    610                 615                 620                 


Leu Ala Ala Ile Thr Leu Ile Ile Gly Thr Phe Glu Arg Met Lys Cys 
625                 630                 635                 640 


Phe Ser Glu Glu Asn His Glu Pro Leu Arg Thr Gln Cys Ala Leu Ala 
                645                 650                 655     


Ala Ser Lys Leu Leu Lys Lys Pro Asp Gln Gly Arg Ala Val Ser Thr 
            660                 665                 670         


Cys Ala His Leu Phe Trp Ser Gly Arg Asn Thr Asp Lys Asn Gly Glu 
        675                 680                 685             


Glu Leu His Gly Gly Lys Arg Val Met Glu Cys Leu Lys Lys Ala Leu 
    690                 695                 700                 


Lys Ile Ala Asn Gln Cys Met Asp Pro Ser Leu Gln Val Gln Leu Phe 
705                 710                 715                 720 


Ile Glu Ile Leu Asn Arg Tyr Ile Tyr Phe Tyr Glu Lys Glu Asn Asp 
                725                 730                 735     


Ala Val Thr Ile Gln Val Leu Asn Gln Leu Ile Gln Lys Ile Arg Glu 
            740                 745                 750         


Asp Leu Pro Asn Leu Glu Ser Ser Glu Glu Thr Glu Gln Ile Asn Lys 
        755                 760                 765             


His Phe His Asn Thr Leu Glu His Leu Arg Leu Arg Arg Glu Ser Pro 
    770                 775                 780                 


Glu Ser Glu Gly Pro Ile Tyr Glu Gly Leu Ile Leu 
785                 790                 795     


<210>  2
<211>  2391
<212>  DNA
<213>  Mus musculus

<400>  2
atgcctacaa cacagcagtc accccaggat gagcaggaaa aacttttgga tgaagccatc       60

caggctgtga aggttcagtc attccagatg aaaagatgcc tggacaaaaa caagctgatg      120

gatgctctga agcatgcctc caatatgctt ggagagctcc ggacctctat gctgtcacca      180

aagagttact atgaacttta tatggctatt tctgatgaac tgcactactt ggaggtctac      240

ctgactgatg aatttgctaa aggaagaaag gtggcagatc tctatgaact tgtacagtac      300

gcgggaaaca ttattccaag gctttatctc ttgatcacag ttggagttgt atatgtcaag      360

tcatttcctc aatccaggaa agatattttg aaagatttgg tagaaatgtg ccgtggtgtg      420

cagcatccgc taaggggttt gtttcttcga aattaccttc ttcagtgtac taggaacatt      480

ttacctgatg aaggagagcc aacagatgaa gaaacaactg gtgatatcag tgattccatg      540

gattttgtac tactcaactt tgcagaaatg aataagctct gggtgcggat gcagcatcaa      600

ggacatagtc gagatagaga aaaaagagaa cgagagagac aagaactgag aattttagtg      660

ggaacaaatt tggtgcgcct tagtcagttg gaaggtgtaa atgtggaacg ttacaaacag      720

attgttctaa caggcattct ggagcaggtt gtgaattgta gggatgctct ggctcaggag      780

tatctcatgg agtgcatcat tcaggttttt cctgatgagt ttcatcttca gactttgaat      840

ccttttctta gagcttgtgc tgaattacac caaaatgtaa atgtgaaaaa cataatcatt      900

gctttaattg acagattagc tttatttgct catcgtgaag atggacccgg aattccagct      960

gagattaaac tttttgacat attttcacaa caggtggcta cagtcataca gtccagacaa     1020

gacatgccat cagaggatgt tgtatcttta caagtctctc tcattaatct tgctatgaaa     1080

tgttaccctg atcgtgtgga ctacgtcgat aaagttctag aaacaacagt ggagatattc     1140

aataagctta accttgaaca tattgctacc agtagtgcag tttcaaagga gcttaccaga     1200

cttttgaaga tacctgttga tacttacaac aatatcttaa cagtattaaa gttaaagcat     1260

ttccacccac tttttgagta ctttgactac gagtccagaa agagcatgag ctgttatgtg     1320

cttagtaatg ttctggatta taacacagaa atcgtctctc aggaccaggt agattccata     1380

atgaatttgg tgtccacatt gattcaggat cagccagacc aacctgtaga agaccctgat     1440

ccagaagact tcgctgatga acagagcctt gttggccgat ttattcatct gctacgttct     1500

gatgatcctg accagcagta tttgattttg aatacggcac gaaaacattt tggggctggt     1560

ggaaatcagc ggattcgctt cacactgcca cctttggtat ttgcagctta ccagttggct     1620

tttcgataca aagagaattc ccaaatggat gacaagtggg aaaagaaatg ccagaagata     1680

ttttcatttg ctcaccagac tatcagtgct ttgattaaag ctgagctggc tgaattacca     1740

ctgagacttt ttcttcaagg agcattagct gctggagaaa ttggctttga aaatcatgaa     1800

acagtagcat atgaatttat gtcccaggca ttttctctat atgaagatga aatcagtgat     1860

tctaaagcac agctggctgc tatcaccttg atcatcggta cttttgagag gatgaaatgc     1920

ttcagtgaag agaatcatga acccttgaga actcagtgtg cacttgctgc atcaaaactt     1980

ctgaaaaaac cagatcaagg ccgagccgtg agcacatgtg cgcatctctt ttggtctggc     2040

cgaaacacag acaaaaatgg ggaagagctt catggaggta aaagggtcat ggagtgccta     2100

aagaaggcac taaaaatagc aaatcagtgc atggacccct ctctacaagt tcagctcttt     2160

atagagattc tgaacaggta catctatttc tatgaaaaag aaaatgatgc ggtaaccatt     2220

caagtcttga accaacttat tcaaaagatt cgagaagatc tcccaaatct tgagtccagt     2280

gaagaaacag aacaaataaa caagcatttt cacaacacat tggagcactt gcgctcaaga     2340

cgggaatcac cagagtctga ggggccaatc tatgaaggtc tcatccttta a              2391


<210>  3
<211>  2391
<212>  DNA
<213>  Mus musculus

<400>  3
atgcccacaa cacagcagag cccacaggat gaacaggaaa agctgctgga tgaggccatc       60

caggctgtga aagtgcagtc cttccagatg aaaagatgtc tggataagaa taagctgatg      120

gacgccctga agcatgccag caacatgctg ggcgagctga ggaccagcat gctgtctccc      180

aagtcctact acgagctgta catggccatt tctgacgagc tgcactacct ggaggtgtac      240

ctcacagatg agttcgccaa ggggagaaag gtggccgatc tgtatgagct ggtgcagtat      300

gctggcaaca tcatccccag gctgtacctg ctgatcaccg tgggcgtggt gtatgtgaag      360

agcttccccc agtctagaaa ggatatcctg aaggacctgg tggaaatgtg caggggagtg      420

cagcatcctc tgagaggcct gtttctgaga aactacctgc tgcagtgtac caggaatatc      480

ctgcccgacg aaggcgagcc tactgatgaa gaaacaaccg gcgacatcag cgacagcatg      540

gattttgtgc tgctgaactt cgccgagatg aacaaactgt gggtgagaat gcagcaccag      600

ggacacagca gggacagaga gaagagagag agggagagac aggagctgag aatcctggtg      660

ggcaccaacc tggtgaggct gtcccagctg gagggcgtga atgtggagag atataagcag      720

attgtgctga caggaatcct ggagcaggtg gtgaactgca gagatgccct ggcccaggag      780

tatctgatgg aatgcatcat tcaggtgttc ccagatgagt tccacctgca gacactgaac      840

cctttcctga gggcctgcgc cgagctgcat cagaacgtga acgtcaagaa catcatcatt      900

gctctgattg acaggctggc cctgtttgcc catagagagg atggacctgg catcccagcc      960

gagatcaagc tgtttgacat tttcagccag caggtggcca ccgtgatcca gtctaggcag     1020

gacatgcctt ccgaagatgt ggtgagcctg caggtgtccc tgatcaatct ggccatgaag     1080

tgttaccctg atagagtgga ttacgtggac aaggtgctgg agaccacagt ggagatcttc     1140

aacaagctga acctggagca catcgccact tcttctgctg tgtctaaaga actgacaaga     1200

ctgctgaaga tccctgtgga cacctacaac aacattctga ccgtgctgaa gctgaaacac     1260

ttccatccac tgttcgagta ctttgattat gagagcagga agtccatgag ctgctacgtg     1320

ctgagcaatg tgctggacta caatacagaa atcgtgtccc aggatcaggt ggacagcatc     1380

atgaatctgg tgagcacact gatccaggac cagcctgatc agccagtgga ggaccccgac     1440

cctgaggact tcgctgacga gcagagcctg gtgggcaggt tcatccacct gctgaggtct     1500

gatgatccag accagcagta cctgatcctg aacaccgcca ggaagcactt tggagccgga     1560

ggcaaccaga ggatcagatt caccctgcct cccctggtgt ttgccgccta ccagctggct     1620

ttcagataca aggaaaattc ccagatggat gacaagtggg agaaaaaatg ccagaagatc     1680

ttttcttttg ctcaccagac catctctgcc ctgatcaaag ctgagctggc tgaactgcca     1740

ctgagactgt tcctccaggg ggccctggct gccggggaga tcggctttga gaaccatgag     1800

actgtggcct atgaattcat gtctcaggcc ttctctctgt acgaagatga gatcagcgac     1860

agcaaggctc agctggctgc tatcacactg atcattggaa catttgaaag gatgaagtgc     1920

ttctccgagg aaaaccacga gccactgaga acacagtgtg cactggccgc ctccaagctg     1980

ctgaagaagc ctgaccaggg cagagccgtg tctacctgtg cccacctgtt ctggagcgga     2040

agaaacacag acaaaaatgg agaggagctg catggcggca agagggtgat ggagtgcctg     2100

aagaaagccc tgaagattgc caaccagtgc atggacccaa gcctgcaggt gcagctgttc     2160

atcgagatcc tgaacaggta catctacttc tacgagaagg agaatgacgc cgtgaccatt     2220

caggtgctga atcagctgat ccagaaaatc agggaagacc tgcccaacct ggagagctct     2280

gaagagacag agcagatcaa caagcatttt cacaacactc tggaacatct gaggtccagg     2340

agggagtccc cagagtctga gggacccatc tatgaggggc tgatcctgtg a              2391


<210>  4
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Phe Leu Gly Gly Phe Phe Gly Pro Ile Cys Glu Ile Asp Ile 
1               5                   10                  15      


Val Leu Asn Asp Gly Glu Thr Arg Lys Met Ala Glu Met Lys Thr Glu 
            20                  25                  30          


Asp Gly Lys Val Glu Lys His Tyr Leu Phe Tyr Asp Gly Glu Ser Val 
        35                  40                  45              


Ser Gly Lys Val Asn Leu Ala Phe Lys Gln Pro Gly Lys Arg Leu Glu 
    50                  55                  60                  


His Gln Gly Ile Arg Ile Glu Phe Val Gly Gln Ile Glu Leu Phe Asn 
65                  70                  75                  80  


Asp Lys Ser Asn Thr His Glu Phe Val Asn Leu Val Lys Glu Leu Ala 
                85                  90                  95      


Leu Pro Gly Glu Leu Thr Gln Ser Arg Ser Tyr Asp Phe Glu Phe Met 
            100                 105                 110         


Gln Val Glu Lys Pro Tyr Glu Ser Tyr Ile Gly Ala Asn Val Arg Leu 
        115                 120                 125             


Arg Tyr Phe Leu Lys Val Thr Ile Val Arg Arg Leu Thr Asp Leu Val 
    130                 135                 140                 


Lys Glu Tyr Asp Leu Ile Val His Gln Leu Ala Thr Tyr Pro Asp Val 
145                 150                 155                 160 


Asn Asn Ser Ile Lys Met Glu Val Gly Ile Glu Asp Cys Leu His Ile 
                165                 170                 175     


Glu Phe Glu Tyr Asn Lys Ser Lys Tyr His Leu Lys Asp Val Ile Val 
            180                 185                 190         


Gly Lys Ile Tyr Phe Leu Leu Val Arg Ile Lys Ile Gln His Met Glu 
        195                 200                 205             


Leu Gln Leu Ile Lys Lys Glu Ile Thr Gly Ile Gly Pro Ser Thr Thr 
    210                 215                 220                 


Thr Glu Thr Glu Thr Ile Ala Lys Tyr Glu Ile Met Asp Gly Ala Pro 
225                 230                 235                 240 


Val Lys Gly Glu Ser Ile Pro Ile Arg Leu Phe Leu Ala Gly Tyr Asp 
                245                 250                 255     


Pro Thr Pro Thr Met Arg Asp Val Asn Lys Lys Phe Ser Val Arg Tyr 
            260                 265                 270         


Phe Leu Asn Leu Val Leu Val Asp Glu Glu Asp Arg Arg Tyr Phe Lys 
        275                 280                 285             


Gln Gln Glu Ile Ile Leu Trp Arg Lys Ala Pro Glu Lys Leu Arg Lys 
    290                 295                 300                 


Gln Arg Thr Asn Phe His Gln Arg Phe Glu Ser Pro Glu Ser Gln Ala 
305                 310                 315                 320 


Ser Ala Glu Gln Pro Glu Met 
                325         


<210>  5
<211>  984
<212>  DNA
<213>  Mus musculus

<400>  5
atgagttttc ttggaggctt ttttggtccc atttgtgaga ttgatgttgc ccttaatgat       60

ggggaaacca ggaaaatggc agaaatgaaa actgaggatg gcaaagtaga aaaacactat      120

ctcttctatg atggcgagtc tgtctcagga aaggtaaacc tagcctttaa gcagcctgga      180

aagaggctag agcatcaagg aattagaatt gaatttgtag gtcaaattga gcttttcaat      240

gacaagagta atactcatga atttgtaaac ctagtgaagg aactagcctt gcctggagaa      300

ctgactcaga gcagaagcta tgactttgaa tttatgcaag ttgaaaagcc atatgagtca      360

tacatcggtg ccaatgtccg cctgaggtat tttcttaagg tgacaattgt gagaagattg      420

acagacttag tgaaagagta cgatcttatt gttcatcagc tagccaccta tcctgatgtc      480

aacaactcta ttaaaatgga agtgggcatt gaagactgtc tgcacataga gtttgaatat      540

aataagtcca agtatcattt aaaggatgta attgttggaa aaatttactt cttattagta      600

agaataaaaa tacaacacat ggaattacag ctgatcaaga aagagatcac aggaattgga      660

cccagcacca caacagagac agaaacaatc gctaagtatg aaataatgga tggggcgcca      720

gtaaaaggag aatctattcc gataagattg ttcttagcag ggtatgaccc aacccccacg      780

atgagagatg tgaacaagaa gttttcagta aggtactttc taaacctcgt gcttgttgat      840

gaggaggacc gaaggtactt caagcagcag gagatcatcc tgtggagaaa agcacccgag      900

aaactgagaa aacagaggac gaactttcac cagcggtttg aatctccaga ctcgcaggcc      960

tctgcggagc agcctgagat gtaa                                             984


<210>  6
<211>  984
<212>  DNA
<213>  Mus musculus

<400>  6
atgagcttcc tgggcggctt cttcggcccc atctgtgaga tcgacgtggc cctgaacgac       60

ggcgagacca gaaagatggc cgagatgaag acagaggatg gcaaggtgga gaagcactac      120

ctgttctacg acggagagtc tgtgtccggc aaggtgaacc tggccttcaa gcagcctggg      180

aagaggctgg agcaccaggg catcagaatc gagttcgtgg gccagatcga gctgttcaac      240

gacaagagca acacccacga gtttgtgaac ctggtgaagg agctggctct gcctggcgag      300

ctgacccaga gcagaagcta cgacttcgag ttcatgcagg tggagaagcc ttacgagagc      360

tacatcggcg ccaacgtgag actgagatac ttcctgaagg tgaccatcgt gaggagactg      420

accgacctgg tgaaggagta tgacctgatc gtgcaccagc tggccaccta ccctgacgtg      480

aacaacagca tcaagatgga ggtgggcatc gaggactgcc tgcacatcga gttcgagtac      540

aacaagtcca agtaccacct gaaggacgtg atcgtgggca agatctactt cctgctggtg      600

aggatcaaga tccagcacat ggagctgcag ctgatcaaga aggagatcac cggcatcggc      660

ccttccacaa ccaccgagac agagacaatc gccaagtacg agatcatgga cggcgcccct      720

gtgaagggcg agagcatccc tatcaggctg ttcctggccg gctacgaccc tacccctacc      780

atgagagacg tgaacaagaa gttcagcgtg aggtacttcc tgaacctggt gctggtggac      840

gaggaggaca gaagatactt caagcagcag gagatcatcc tgtggaggaa ggcccctgag      900

aagctgagga agcagaggac caacttccac cagagattcg agtcccctga cagccaggcc      960

agcgccgagc agccagagat gtga                                             984


<210>  7
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Phe Phe Gly Phe Gly Gln Ser Val Glu Val Glu Ile Leu Leu 
1               5                   10                  15      


Asn Asp Ala Glu Ser Arg Lys Arg Ala Glu His Lys Thr Glu Asp Gly 
            20                  25                  30          


Lys Lys Glu Lys Tyr Phe Leu Phe Tyr Asp Gly Glu Thr Val Ser Gly 
        35                  40                  45              


Lys Val Ser Leu Ala Leu Lys Asn Pro Asn Lys Arg Leu Glu His Gln 
    50                  55                  60                  


Gly Ile Lys Ile Glu Phe Ile Gly Gln Ile Glu Leu Tyr Tyr Asp Arg 
65                  70                  75                  80  


Gly Asn His His Glu Phe Val Ser Leu Val Lys Asp Leu Ala Arg Pro 
                85                  90                  95      


Gly Glu Ile Thr Gln Ser Gln Ala Phe Asp Phe Glu Phe Thr His Val 
            100                 105                 110         


Glu Lys Pro Tyr Glu Ser Tyr Thr Gly Gln Asn Val Lys Leu Arg Tyr 
        115                 120                 125             


Phe Leu Arg Ala Thr Ile Ser Arg Arg Leu Asn Asp Val Val Lys Glu 
    130                 135                 140                 


Met Asp Ile Val Val His Thr Leu Ser Thr Tyr Pro Glu Leu Asn Ser 
145                 150                 155                 160 


Ser Ile Lys Met Glu Val Gly Ile Glu Asp Cys Leu His Ile Glu Phe 
                165                 170                 175     


Glu Tyr Asn Lys Ser Lys Tyr His Leu Lys Asp Val Ile Val Gly Lys 
            180                 185                 190         


Ile Tyr Phe Leu Leu Val Arg Ile Lys Ile Lys His Met Glu Ile Asp 
        195                 200                 205             


Ile Ile Lys Arg Glu Thr Thr Gly Thr Gly Pro Asn Val Tyr His Glu 
    210                 215                 220                 


Asn Asp Thr Ile Ala Lys Tyr Glu Ile Met Asp Gly Ala Pro Val Arg 
225                 230                 235                 240 


Gly Glu Ser Ile Pro Ile Arg Leu Phe Leu Ala Gly Tyr Glu Leu Thr 
                245                 250                 255     


Pro Thr Met Arg Asp Ile Asn Lys Lys Phe Ser Val Arg Tyr Tyr Leu 
            260                 265                 270         


Asn Leu Val Leu Ile Asp Glu Glu Glu Arg Arg Tyr Phe Lys Gln Gln 
        275                 280                 285             


Glu Val Val Leu Trp Arg Lys Gly Asp Ile Val Arg Lys Ser Met Ser 
    290                 295                 300                 


His Gln Ala Ala Ile Ala Ser Gln Arg Phe Glu Gly Thr Thr Ser Leu 
305                 310                 315                 320 


Gly Glu Val Arg Thr Pro Ser Gln Leu Ser Asp Asn Asn Cys Arg Gln 
                325                 330                 335     


<210>  8
<211>  1011
<212>  DNA
<213>  Mus musculus

<400>  8
atgagcttct tcggcttcgg gcagagcgtg gaggtggaaa tcttgctgaa tgatgcggag       60

agtaggaagc gagcggagca caagactgag gacgggaaga aggagaaata tttcctcttc      120

tacgacgggg aaaccgtctc ggggaaagtg agcctatcac tgaagaaccc caacaagcga      180

ctagagcacc agggcatcaa gatcgagttc attgggcaga tcgaactcta ctatgaccgt      240

gggaaccacc atgagtttgt gtctttggtg aaggacctgg ctcggccagg agagatcacc      300

caatcgcagg ccttcgactt tgagttcacc catgtggaaa agccgtatga atcctacaca      360

ggacagaatg tgaagctccg ctatttcctt cgagccacca tcagccgccg cctcaatgat      420

gttgttaaag agatggacat tgtagttcac acacttagca cataccccga gctgaactca      480

tccatcaaga tggaagttgg cattgaggat tgcctgcaca ttgaatttga gtacaacaaa      540

tccaaatacc acttgaaaga tgtcattgta gggaagatat acttcctgct ggtgagaatc      600

aagatcaagc acatggagat agacatcatc aaacgagaga caacaggcac gggtcccaac      660

gtgtaccacg agaacgacac aatagcgaag tatgagatca tggacggggc accagtccga      720

ggtgagtcca tccccatcag gctcttcctg gcagggtatg agctcacacc caccatgcgt      780

gacataaata agaagttctc tgtgcgctat tacctcaact tggtgctgat agatgaggag      840

gaacggcgct acttcaagca gcaggaagtg gtgttgtggc ggaagggtga catcgtacgg      900

aagagcatgt cccaccaggc agccattgcc tcacagcgct tcgagggcac aacctccctg      960

ggtgaggtgc ggacccctgg ccaactgtct gacaacaaca gcaggcagta g              1011


<210>  9
<211>  1011
<212>  DNA
<213>  Mus musculus

<400>  9
atgagttttt ttgggtttgg acagtcagtg gaggtggaga tcctgctgaa cgacgccgag       60

agcaggaaga gggccgagca caagacagag gatggcaaga aggagaagta cttcctgttc      120

tacgacggag agaccgtgag cggcaaggtg tccctgagcc tgaagaaccc aaacaagaga      180

ctggagcacc agggcatcaa gatcgagttc atcggccaga tcgagctgta ctacgacagg      240

ggcaaccacc acgagttcgt gagcctggtg aaggacctgg ccagacctgg cgagatcacc      300

cagagccagg ccttcgactt cgagttcacc cacgtggaga agccttacga gagctacaca      360

ggccagaacg tgaagctgag gtacttcctg agagccacca tcagcagaag actgaacgac      420

gtggtgaagg agatggacat cgtggtgcac accctgagca cctaccctga gctgaactct      480

tccatcaaga tggaggtggg catcgaggac tgcctgcaca tcgagttcga gtacaacaag      540

agcaagtacc acctgaagga cgtgatcgtg ggcaagatct acttcctgct ggtgagaatc      600

aagatcaagc acatggagat cgacatcatc aagagagaga ccacaggcac aggccctaac      660

gtgtaccacg agaacgacac catcgccaag tacgagatca tggacggcgc ccctgtgaga      720

ggcgagagca tccctatcag gctgttcctg gccggctacg agctgacccc taccatgagg      780

gacatcaaca agaagttcag cgtgagatac tacctgaacc tggtgctgat cgatgaggag      840

gagagaagat acttcaagca gcaggaggtg gtgctgtgga gaaagggcga catcgtgaga      900

aagagcatga gccaccaggc cgccatcgcc agccagagat tcgagggcac caccagcctg      960

ggcgaggtga ggacccctgg ccagctgagc gacaacaaca gcagacagtg a              1011


<210>  10
<211>  2391
<212>  DNA
<213>  Homo sapiens

<400>  10
atgcctacaa cacagcagtc ccctcaggat gagcaggaaa agctcttgga tgaagccata       60

caggctgtga aggtccagtc attccaaatg aagagatgcc tggacaaaaa caagctcatg      120

gatgctctaa aacatgcttc taatatgctt ggtgaactcc ggacttctat gttatcacca      180

aagagttact atgaacttta tatggccatt tctgatgaac tgcactactt ggaggtctac      240

ctgacagatg agtttgctaa aggaaggaaa gtggcagatc tctacgaact tgtacagtat      300

gctggaaaca ttatcccaag gctttacctt ctgatcacag ttggagttgt atatgtcaag      360

tcatttcctc agtccaggaa ggatattctg aaagatttgg tagaaatgtg ccgtggtgtg      420

caacatccct tgaggggtct gtttcttcga aattaccttc ttcagtgtac cagaaatatc      480

ttacctgatg aaggagagcc aacagatgaa gaaacaactg gtgacatcag tgattccatg      540

gatttcgtac tgctcaactt tgcagaaatg aacaagctct gggtgcgaat gcagcatcag      600

ggacatagcc gagatagaga aaaaagagaa cgagaaagac aagaactgag gattctagtg      660

ggaacaaatt tggtgcgcct cagtcagttg gaaggtgtaa atgtggaacg ttacaaacag      720

attgttctga ctggcatatt ggagcaagtt gtaaactgta gggatgcttt ggctcaagaa      780

tatctcatgg agtgtattat tcaggtattc cctgatgaat ttcacctcca gactttgaat      840

cctttccttc gggcctgtgc tgagttacac cagaatgtaa atgtgaagaa cataatcatt      900

gctttaattg atagattagc tttatttgct caccgtgaag atggacctgg aatcccagcg      960

gatattaaac tattcgatat attctcacag caggtggcta cagtgataca gtcaagacaa     1020

gacatgcctt cagaggatgt tgtatcttta caagtatctc ttattaatct tgccatgaaa     1080

tgttaccctg atcgtgtgga ctatgttgat aaagtactag aaacaacagt ggagatattc     1140

aataagctca accttgaaca tattgctacc agtagtgcag tttcaaagga actcaccaga     1200

ctattgaaaa taccagttga cacttacaac aatatattaa cagtcttgaa attaaaacat     1260

ttccacccac tctttgagta ctttgactac gagtccagaa agagcatgag ttgttatgtg     1320

cttagtaatg ttctggatta taacacagaa attgtatctc aagaccaggt ggattccata     1380

atgaatttgg tatccacgtt gattcaagat cagccagatc aacctgtaga agaccctgat     1440

ccagaagatt tcgctgatga gcagagcctt gtgggccgct tcattcatct gctgcgctct     1500

gaggaccctg accagcagta cttgatattg aacacagcac gaaaacattt cggagctggt     1560

ggaaatcagc ggattcgctt cacactgcca cctttggtat ttgcagctta ccagctggca     1620

tttcgatata aagagaactc taaagtggat gacaaatggg aaaagaaatg ccagaagata     1680

ttctcatttg cccaccagac tatcagtgct ttgatcaaag cagagctggc agaattgccg     1740

ttaagactat tccttcaagg agcactagct gctggggaaa ttggatttga aaatcatgaa     1800

acagtcgcat atgaattcat gtcccaggca ttctctctgt atgaagatga aatcagcgat     1860

tccaaagcac agcttgctgc catcaccttg atcattggca catttgaaag gatgaagtgc     1920

ttcagtgaag agaatcatga acctctgagg actcagtgtg cccttgctgc atccaaactt     1980

ctaaagaaac ctgatcaggg ccgagctgtg agcacctgtg cacatctctt ctggtctggc     2040

agaaacacgg acaaaaatgg ggaggagctt cacggaggca agagggtaat ggagtgccta     2100

aaaaaagctc taaaaatagc aaatcagtgc atggacccct ctctacaagt gcagctattc     2160

atagaaattc tgaacagata tatctacttc tatgaaaagg aaaatgatgc ggtaacaatt     2220

caggtattaa accagcttat ccaaaagatt cgagaagacc tcccgaatct tgaatccagt     2280

gaagaaacag agcagattaa caaacacttt cataacacac tggagcattt gcgcttgcgg     2340

cgggaatcac cagaatccga ggggccaatt tatgaaggac tcatccttta a              2391


