                         SEQUENCE LISTING

<110>  THE CHILDREN'S HOSPITAL OF PHILADELPHIA
 
<120>  COMPOSITIONS AND METHODS FOR INDUCIBLE ALTERNATIVE SPLICING 
       REGULATION OF GENE EXPRESSION

<130>  CHOP.P0041WO

<140>  not yet known
<141>  2021-02-12

<150>  US 62/975,400
<151>  2020-02-12

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  1730
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SMN2 Minigene

<400>  1
aagcttggca atccggtact gttggtaaag ccacaaacgc caccatgata attcccccac       60

cacctcccat atgtccagat tctcttgatg atgctgatgc tttgggaagt atgttaattt      120

catggtacat gagtggctat catactggct attatatggt aagtaatcac tcagcatctt      180

ttcctgacaa tttttttgta gttatgtgac tttgttttgt aaatttataa aatactactt      240

gcttctctct ttatattact aaaaaataaa aataaaaaaa tacaactgtc tgaggcttaa      300

attactcttg cattgtccct aagtataatt ttagttaatt ttaaaaagct ttcatgctat      360

tgttagatta ttttgattat acacttttga attgaaatta tactttttct aaataatgtt      420

ttaatctctg atttgaaatt gattgtaggg aatggaaaag atgggataat ttttcataaa      480

tgaaaaatga aattcttttt tttttttttt tttttttgag acggagtctt gctctgttgc      540

ccaggctgga gtgcaatggc gtgatcttgg ctcacagcaa gctctgcctc ctggattcac      600

gccattctcc tgcctcagcc tcagaggtag ctgggactac aggtgcctgc caccacgcct      660

ggctagctgg gattagaggt ccccaccacc atgcctggct aattttttgt actttcagta      720

gaaacggggt tttgccatgt tggccaggct gttctcgaac tcctgagctc aggtgatcca      780

actgtctcgg cctcccaaag tgctgggatt acaggcgtga gccactgtgc ctagcctgag      840

ccaccacgcc ggcctaattt ttaaattttt tgtagagaca gggtctcatt atgttgccca      900

gggtggtgtc aagctccagg tctcaagtga tccccctacc tccgcctccc aaagttgtgg      960

gattgtaggc atgagccact gcaagaaaac cttaactgca gcctaataat tgttttcttt     1020

gggataactt ttaaagtaca ttaaaagact atcaacttaa tttctgatca tattttgttg     1080

aataaaataa gtaaaatgtc ttgtgaaaca aaatgctttt taacatccat ataaagctat     1140

ctatatatag ctatctatat ctatatagct atttttttta acttccttta ttttccttac     1200

agggttttag acaaaatcaa aaagaaggaa ggtgctcaca ttccttaaat ataaggagta     1260

agtctgccag cattatgaaa gtgaatctta cttttgtaaa actttatggt ttgtggaaaa     1320

caaatgtttt tgaacattta aaaagttcag atgttagaaa gttgaaaggt taatgtaaaa     1380

caatcaatat taaagaattt tgatgccaaa actattagat aaaaggttaa tctacatccc     1440

tactagaatt ctcatactta actggttggt tgtgtggaag aaacatactt tcacaataaa     1500

gagctttagg atatgatgcc attttatatc actagtaggc agaccagcag actttttttt     1560

attgtgatat gggataacct aggcatactg cactgtacac tctgacatat gaagtgctct     1620

agtcaagttt aactggtgtc cacagaggac atggtttaac tggaattcgt caagcctctg     1680

gttctaattt ctcatttgca ggaaatgctg gcatagagca gcacggatcc                1730


<210>  2
<211>  1730
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SMN2ind Minigene

<400>  2
aagcttggca atccggtact gttggtaaag ccacaaacgc caccatgata attcccccac       60

cacctcccat atgtccagat tctcttgatg atgctgatgc tttgggaagt atgttaattt      120

catggtacat gagtggctat catactggct attatatggt aagtaatcac tcagcatctt      180

ttcctgacaa tttttttgta gttatgtgac tttgttttgt aaatttataa aatactactt      240

gcttctctct ttatattact aaaaaataaa aataaaaaaa tacaactgtc tgaggcttaa      300

attactcttg cattgtccct aagtataatt ttagttaatt ttaaaaagct ttcatgctat      360

tgttagatta ttttgattat acacttttga attgaaatta tactttttct aaataatgtt      420

ttaatctctg atttgaaatt gattgtaggg aatggaaaag atgggataat ttttcataaa      480

tgaaaaatga aattcttttt tttttttttt tttttttgag acggagtctt gctctgttgc      540

ccaggctgga gtgcaatggc gtgatcttgg ctcacagcaa gctctgcctc ctggattcac      600

gccattctcc tgcctcagcc tcagaggtag ctgggactac aggtgcctgc caccacgcct      660

ggctagctgg gattagaggt ccccaccacc atgcctggct aattttttgt actttcagta      720

gaaacggggt tttgccatgt tggccaggct gttctcgaac tcctgagctc aggtgatcca      780

actgtctcgg cctcccaaag tgctgggatt acaggcgtga gccactgtgc ctagcctgag      840

ccaccacgcc ggcctaattt ttaaattttt tgtagagaca gggtctcatt atgttgccca      900

gggtggtgtc aagctccagg tctcaagtga tccccctacc tccgcctccc aaagttgtgg      960

gattgtaggc atgagccact gcaagaaaac cttaactgca gcctaataat tgttttcttt     1020

gggataactt ttaaagtaca ttaaaagact atcaacttaa tttctgatca tattttgttg     1080

aataaaataa gtaaaatgtc ttgtgaaaca aaatgctttt taacatccat ataaagctat     1140

ctatatatag ctatctatat ctatatagct atttttttta acttccttta ttttccttcc     1200

aggattttag acaaaatcaa aaagaaggaa ggtgctcaca ttccttaaat ataaggagta     1260

agtctgccag cattatgaaa gtgaatctta cttttgtaaa actttatggt ttgtggaaaa     1320

caaatgtttt tgaacattta aaaagttcag atgttagaaa gttgaaaggt taatgtaaaa     1380

caatcaatat taaagaattt tgatgccaaa actattagat aaaaggttaa tctacatccc     1440

tactagaatt ctcatactta actggttggt tgtgtggaag aaacatactt tcacaataaa     1500

gagctttagg atatgatgcc attttatatc actagtaggc agaccagcag actttttttt     1560

attgtgatat gggataacct aggcatactg cactgtacac tctgacatat gaagtgctct     1620

agtcaagttt aactggtgtc cacagaggac atggtttaac tggaattcgt caagcctctg     1680

gttctaattt ctcatttgca ggaaatgctg gcatagagca gcacggatcc                1730


<210>  3
<211>  1730
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SMN2act Minigene

<400>  3
aagcttggca atccggtact gttggtaaag ccacaaacgc caccatgata attcccccac       60

cacctcccat atgtccagat tctcttgatg atgctgatgc tttgggaagt atgttaattt      120

catggtacat gagtggctat catactggct attatatggt aagtaatcac tcagcatctt      180

ttcctgacaa tttttttgta gttatgtgac tttgttttgt aaatttataa aatactactt      240

gcttctctct ttatattact aaaaaataaa aataaaaaaa tacaactgtc tgaggcttaa      300

attactcttg cattgtccct aagtataatt ttagttaatt ttaaaaagct ttcatgctat      360

tgttagatta ttttgattat acacttttga attgaaatta tactttttct aaataatgtt      420

ttaatctctg atttgaaatt gattgtaggg aatggaaaag atgggataat ttttcataaa      480

tgaaaaatga aattcttttt tttttttttt tttttttgag acggagtctt gctctgttgc      540

ccaggctgga gtgcaatggc gtgatcttgg ctcacagcaa gctctgcctc ctggattcac      600

gccattctcc tgcctcagcc tcagaggtag ctgggactac aggtgcctgc caccacgcct      660

ggctagctgg gattagaggt ccccaccacc atgcctggct aattttttgt actttcagta      720

gaaacggggt tttgccatgt tggccaggct gttctcgaac tcctgagctc aggtgatcca      780

actgtctcgg cctcccaaag tgctgggatt acaggcgtga gccactgtgc ctagcctgag      840

ccaccacgcc ggcctaattt ttaaattttt tgtagagaca gggtctcatt atgttgccca      900

gggtggtgtc aagctccagg tctcaagtga tccccctacc tccgcctccc aaagttgtgg      960

gattgtaggc atgagccact gcaagaaaac cttaactgca gcctaataat tgttttcttt     1020

gggataactt ttaaagtaca ttaaaagact atcaacttaa tttctgatca tattttgttg     1080

aataaaataa gtaaaatgtc ttgtgaaaca aaatgctttt taacatccat ataaagctat     1140

ctatatatag ctatctatat ctatatagct atttttttta acttccttta ttttccttac     1200

agggttttag acaaaatcaa aaagaaggaa ggtgctcaca ttccttaaat ataaaaggta     1260

agtctgccag cattatgaaa gtgaatctta cttttgtaaa actttatggt ttgtggaaaa     1320

caaatgtttt tgaacattta aaaagttcag atgttagaaa gttgaaaggt taatgtaaaa     1380

caatcaatat taaagaattt tgatgccaaa actattagat aaaaggttaa tctacatccc     1440

tactagaatt ctcatactta actggttggt tgtgtggaag aaacatactt tcacaataaa     1500

gagctttagg atatgatgcc attttatatc actagtaggc agaccagcag actttttttt     1560

attgtgatat gggataacct aggcatactg cactgtacac tctgacatat gaagtgctct     1620

agtcaagttt aactggtgtc cacagaggac atggtttaac tggaattcgt caagcctctg     1680

gttctaattt ctcatttgca ggaaatgctg gcatagagca gcacggatcc                1730


<210>  4
<211>  1199
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3 Minigene

<400>  4
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acgtatatgg gaatttggag atttgtgact gacttcacta      900

tgtctaattt ttttttgaga cggagttttg ctctgttgcc caggccggag tgcagtggca      960

cagtcttggc tcacagcaac ctctacctcc tgggttcaag cgattctcct gccttagcct     1020

cccgagtagc tgggattaca ggcatgtgcc accacgcctg gctaattttt gtatttttag     1080

tagagacggg gtttcaccat ggtggccagg ctgggttctg gttgtttatg atctttattt     1140

tttggtgatc taggaaccaa acaacaagaa attgttgttt cccgtgggta agaggatcc      1199


<210>  5
<211>  2142
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3int Minigene

<400>  5
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acgtatatgg gaatttggag atttgtgact gacttcacta      900

tgtaatgcaa tgaatctcag ctggagtttg gatagaattt ttgaaagcac gtttttgttt      960

tttgtttgtt ttgtttttgt tttttgtttg ttttgttttt gtttttgttt tttccttgaa     1020

acagagtcct gctctgtcac ccaggctgga gcgcagtggt gtgatcttgg ctcactgcca     1080

cctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac     1140

atgcgtgcac caccatgccc ggctaatttt tcatattttt agtagagatg aggtttcacc     1200

atattggcca ggctgatctc gaattcctga cctcgtgatc cacccacctt agcctcccaa     1260

agtgctggga ttacaggcat gagctactgt gccctgctga aagcacattt ttaatactaa     1320

ttttatcttt caaattcctt ttccaattca gtcttccttt ttatctaaaa tgatggagaa     1380

gttttctttt tttttttttt ttttttgaga cgtagtcttg ctgtgttgcc caggctggag     1440

tacagtagtg cgacctcggc tcactgcaaa ctccgtctcc caggttcaag cgattctcct     1500

gtgtcagcct ctggagtagc tgggattata ggcacgtgcc accacacctg gctaattttt     1560

gtatttttag tagagatggg atcccaccat gttggccagg ctggtttcaa actcctgacc     1620

tcaagtgatc tgcctgcctc agcctcccaa agtgctggga taacaggtgt gagccactgt     1680

gcgtggcctt tttttttttt tttttttttt ttagagacga tatcttgctg cgtttcccag     1740

gatggagtgc aatggcagga ttataaccca ctacattctc tgaactcctg ggttcaaact     1800

gtcctcccac gtagctggga ctagaggcac aggccatcac acctgactaa tttttttttg     1860

agacggagtt ttgctctgtt gcccaggccg gagtgcagtg gcacagtctt ggctcacagc     1920

aacctctacc tcctgggttc aagcgattct cctgccttag cctcccgagt agctgggatt     1980

acaggcatgt gccaccacgc ctggctaatt tttgtatttt tagtagagac ggggtttcac     2040

catggtggcc aggctgggtt ctggttgttt atgatcttta ttttttggtg atctaggaac     2100

caaacaacaa gaaattgttg tttcccgtgg gtaagaggat cc                        2142


<210>  6
<211>  1642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3int1 Minigene

<400>  6
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acgtatatgg gaatttggag atttgtgact gacttcacta      900

tgtaatgcaa tgaatctcag ctggagtttg gatagaattt ttgaaagcac gtttttgttt      960

tttgtttgtt ttgtttttgt tttttgtttg ttttgttttt gtttttgttt tttccttgaa     1020

acagagtcct gctctgtcac ccaggctgga gcgcagtggt gtgatcttgg ctcactgcca     1080

cctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac     1140

atgcgtgcac caccatgccc ggctaatttt tcatattttt agtagagatg aggtttcacc     1200

atattggcca ggctgatctc gatcttgctg cgtttcccag gatggagtgc aatggcagga     1260

ttataaccca ctacattctc tgaactcctg ggttcaaact gtcctcccac gtagctggga     1320

ctagaggcac aggccatcac acctgactaa tttttttttg agacggagtt ttgctctgtt     1380

gcccaggccg gagtgcagtg gcacagtctt ggctcacagc aacctctacc tcctgggttc     1440

aagcgattct cctgccttag cctcccgagt agctgggatt acaggcatgt gccaccacgc     1500

ctggctaatt tttgtatttt tagtagagac ggggtttcac catggtggcc aggctgggtt     1560

ctggttgttt atgatcttta ttttttggtg atctaggaac caaacaacaa gaaattgttg     1620

tttcccgtgg gtaagaggat cc                                              1642


<210>  7
<211>  1597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3int2 Minigene

<400>  7
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acaattcctg acctcgtgat ccacccacct tagcctccca      900

aagtgctggg attacaggca tgagctactg tgccctgctg aaagcacatt tttaatacta      960

attttatctt tcaaattcct tttccaattc agtcttcctt tttatctaaa atgatggaga     1020

agttttcttt tttttttttt tttttttgag acgtagtctt gctgtgttgc ccaggctgga     1080

gtacagtagt gcgacctcgg ctcactgcaa actccgtctc ccaggttcaa gcgattctcc     1140

tgtgtcagcc tctggagtag ctgggattat aggcacatct tgctgcgttt cccaggatgg     1200

agtgcaatgg caggattata acccactaca ttctctgaac tcctgggttc aaactgtcct     1260

cccacgtagc tgggactaga ggcacaggcc atcacacctg actaattttt ttttgagacg     1320

gagttttgct ctgttgccca ggccggagtg cagtggcaca gtcttggctc acagcaacct     1380

ctacctcctg ggttcaagcg attctcctgc cttagcctcc cgagtagctg ggattacagg     1440

catgtgccac cacgcctggc taatttttgt atttttagta gagacggggt ttcaccatgg     1500

tggccaggct gggttctggt tgtttatgat ctttattttt tggtgatcta ggaaccaaac     1560

aacaagaaat tgttgtttcc cgtgggtaag aggatcc                              1597


<210>  8
<211>  1469
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3i3 Minigene

<400>  8
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acgtgccacc acacctggct aatttttgta tttttagtag      900

agatgggatc ccaccatgtt ggccaggctg gtttcaaact cctgacctca agtgatctgc      960

ctgcctcagc ctcccaaagt gctgggataa caggtgtgag ccactgtgcg tggccttttt     1020

tttttttttt ttttttttta gagacgatat cttgctgcgt ttcccaggat ggagtgcaat     1080

ggcaggatta taacccacta cattctctga actcctgggt tcaaactgtc ctcccacgta     1140

gctgggacta gaggcacagg ccatcacacc tgactaattt ttttttgaga cggagttttg     1200

ctctgttgcc caggccggag tgcagtggca cagtcttggc tcacagcaac ctctacctcc     1260

tgggttcaag cgattctcct gccttagcct cccgagtagc tgggattaca ggcatgtgcc     1320

accacgcctg gctaattttt gtatttttag tagagacggg gtttcaccat ggtggccagg     1380

ctgggttctg gttgtttatg atctttattt tttggtgatc taggaaccaa acaacaagaa     1440

attgttgttt cccgtgggta agaggatcc                                       1469


<210>  9
<211>  1283
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3i4 Minigene

<400>  9
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatt cttggaaact tttctggtaa gttctctcgt taccatcttt      120

tgaaatttta agtgaattaa tacatatctt gcttagtctc ttgtgcagga aatgttttcc      180

atttatgaca aaacagttgt tggtaaatgt aaacaattca aattatgaga tgaggtgtta      240

agttctggtg cattatctgt tacctatttc agatgcattt cctagttcac aaattgtgta      300

atgattcttg tcagggcaca cttttcttgg ctgcttacct agtgtggttt ggtgcttgaa      360

gagatagaac ttttgtatga gagaaaaggg aaaatgcagt ttaggtaggg agtgctgtct      420

gcatagaaac agataatttg cttacgttta ccatgtgggg aatatttttg taaagatgga      480

ttaaggctag gtttgaattg tgtgaaattt caaatattgg attaggaaat acaaagttac      540

tgaaagtgag gtactaatgt ttataaaata aaaacttttt cttgccattt gcagatttaa      600

catttttgag tcaatccaag tgccaccatg caggaggttc atgattgtgt agagtaagac      660

ataattttgt tgaggtttaa ctctgaatac ttaatgtggt actgaatact taatgtggta      720

ctgagaggca gcctaactga ccacacagca ttcatatttc atgttgttat tttctctgat      780

cctcattatg gctcttcctg cgggtttgag tcttcatttg ggtaatttag ttattctttg      840

ctgcatttga ttaaggaaat acatcttgct gcgtttccca ggatggagtg caatggcagg      900

attataaccc actacattct ctgaactcct gggttcaaac tgtcctccca cgtagctggg      960

actagaggca caggccatca cacctgacta attttttttt gagacggagt tttgctctgt     1020

tgcccaggcc ggagtgcagt ggcacagtct tggctcacag caacctctac ctcctgggtt     1080

caagcgattc tcctgcctta gcctcccgag tagctgggat tacaggcatg tgccaccacg     1140

cctggctaat ttttgtattt ttagtagaga cggggtttca ccatggtggc caggctgggt     1200

tctggttgtt tatgatcttt attttttggt gatctaggaa ccaaacaaca agaaattgtt     1260

gtttcccgtg ggtaagagga tcc                                             1283


<210>  10
<211>  880
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Benc1 Minigene

<400>  10
aagcttggca atccggtact gttggtaaac tttcctggac tgtgtgcagc agttcaaaga       60

agaggttgag aaaggcgaga cacgtttttg tcttccctac aggtcagtat agcgcaatgc      120

tgagtgaact tgtataggac caaattgaac agaattgaag cagcagtaat aatggaggca      180

aaacagtata aatggtggga aagcaaaaaa atggcacaga atcacatgac attgatgggc      240

agagactgac ccagtactgc aagcaggaca gaatgtgacc acctagtcct tggagtagaa      300

gaatgttgcc ttagatggtt tagggggttt tcttggcata gagctcaagc ctcctctcca      360

gtttcaagaa ggtttttccc tgaagccctt ggaaatacac aggaatgctt cttttgattt      420

ttctaggatc tcattggcca ccatggatgg aaactctagt ttttacttag agtaaggctg      480

cttctatcac cccaaaacaa agcatttctt ttcttctgcc tcctttctcc cccgccaagt      540

tcagggatgc ctaggaaaac agcaagaagt actgtaaccc tcactcaccc ctactccagg      600

cttctcttct ctttgggtgt gtgtcctgtc cctgtactct gcaatgacaa tgaggctctt      660

gtgacagtct tcttgatttt tggctttcaa gcaaatccaa aatacactat cattcctcac      720

caagtgttct ttaatagata aaatgatgtg aatggtccca tgatcaagtc cctgccccga      780

acttacttaa ctcagatctc agttactaat gagttttgct ctgtccatct gcaggatcga      840

tgtggaaaaa aacaagattg aaaacacaat aaccggatcc                            880


<210>  11
<211>  1284
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C12orf4 Minigene

<400>  11
aagcttggca atccggtact gttggtaaaa gtatgtcggc aagtcagctg gtttcccagt       60

gcaggacgcg ctgacagctc gagtgagcgg actgcccagg acttcggaac tagacgaggt      120

gagcccagaa ccgagtgagg atgccctttc agactgacaa ccgttacaga gggattagtc      180

ccctcacccg gctgaagttt ctcagctcga ccgtctgtct tccttttccc tgattaatgt      240

gagcctcaga gcctccgctc tgttggctgt gtgtgttcgg tccagacctt ccatcccatt      300

ttcttatggg aaaccttcct ggatttcacg gttgctaaaa ctgaacccag gcttcaggat      360

agaccaataa aaatttgtat tgctttacgt ttaattttaa ttctttctga gtaaaacaaa      420

taccctatct ctttgcatta tggtgaaata gacgaagatt tttgtgtata gcctacatac      480

agatttgaaa atatagtctg gataattcaa cttagccccg ccccacgaca tgtacaaaag      540

tcctttgagt tttttttata tttcaagtga tatcttttta aataaccgta tgaataattt      600

tttgttcttt atttttccag tgagcaccat aaaataaaaa cgccatacaa tccaacaatt      660

atttattagt tcttgccatt cgcaacatcc tgcctattgc caccatggaa tacaagacag      720

tattccttcc acttcaagaa gactgttttc tagccaagag taagaaatag agcgtgataa      780

gtgccatgat tcaaataagt ctaggctaat atgagagcct gtcgggaccc aatccagttt      840

tagggagttg gataagtctt cctagaggct taactgagcc ctgaagaatt agcaattgtt      900

atccaatgaa attaagatca gtaagagtgc tctaggcaaa ggaaaaggca ttcaaaaaga      960

ttcggcatgg aaggagaagt ttggtgttga cagaagttca gaatggctgt tttcttaaat     1020

caagtttaaa acaaagtgtc ttttttttta aagaagcact ttgttttcat catgaagatg     1080

gaagtacagg gataaacact tgggaaaaac tagaataatt ggctcataga caaaatctct     1140

tgaatggtgg aatgttttct tagaaatggg acagcaataa tgaaacataa tttctttatg     1200

gacttataac ctactgcttt tttgttagtt ctgtacaaat cctgtcaaaa aatatcaaaa     1260

aaaacagaga aagtaaccgg atcc                                            1284


<210>  12
<211>  985
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PDXDC2 Minigene

<400>  12
aagcttggca atccggtact gttggtaaac tcggcttgcc cttcccctgc ttgtgccgtg       60

taccctgtaa cactgtgttt cgatcccagc atcagatggt gagttctact tttggtttgt      120

aaaatcatgt gggattgtgt ttggaaactg cctttcaagt gaagttcttt ttgctggcct      180

ccagataatt agtaacttac tgatgtattg cttggaccct tgcattgtgt aatatatgct      240

tctgttaata tgtgaatgtc catgaaggtt ggttggtata taggtcagga gcacctggct      300

tttaaggagt cttgtaatta ctgtatcgcc tgctttaagt agaaacatgg cagctcaatt      360

aagcaccaga aatttcttct gaagctccta cttttaatga gttagcactg ttgcctggat      420

ttatgaatgg gcagattttg aaaatgaggt tcttcattgt catcgtggaa ttgagttctg      480

cttaatttca gacatgcagg tgataaatct ctccttaatg attccagaag gaaaaggaag      540

ggatggattt tagagttttt tatttctttt gtcaaggtag ttttattttc tagttcaggt      600

acatcagtga gtaatagtag agatacattc atggctgttt taggagagtt aagagaacat      660

ttcatttaaa tgtaaatgtt taaaatcaaa gaaatgttcc tgcatatgta cagtttttac      720

ctttaatctt gtttaactga tttttctagt cttcaaggaa aactatttga ttttcacatc      780

tatgatgaga gaaagccacc atgaaaaatt gtcaagagta agaattgatt tgacattact      840

tttgagagtt atctgcttct tttgcaagtc ataatttttc attttatagc ttttatacta      900

ggcacctcat tttttaatga tttgttttgg ttccaggatc ttgccttcct ggaaaaactt      960

attaaaattg atatataacg gatcc                                            985


<210>  13
<211>  1158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3.OPTXonNGS Minigene

<400>  13
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatc ttggaaactt ttctggtaag ttctctcgtt accatctttt      120

gaaattttaa gtgaattaat acatatcttg cttagtctct tgtgcaggaa atgttttcca      180

tttatgacaa aacagttgtt ggtaaatgta aacaattcaa attatgagat gaggtgttaa      240

gttctggtgc attatctgtt acctatttca gatgcatttc ctagttcaca aattgtgtaa      300

tgattcttgt cagggcacac ttttcttggc tgcttaccta gtgtggtttg gtgcttgaag      360

agatagaact tttgtatgag agaaaaggga aaatgcagtt taggtaggga gtgctgtctg      420

catagaaaca gataatttgc ttacgtttac catgtgggga atatttttgt aaagatggat      480

taaggctagg tttgaattgt gtaaatttca aatattggat taggaaatac aaagttactg      540

aaagtgaggt actaatgttt ataaaataaa aactttttct tgccatttgc agatttaaca      600

tttttgagtc aatccaagta atgcaggagg gccaccatgg gtgtaccaga gtaagacata      660

attttgttga ggtttaactc tgaatactta tgtggtactg aatacttaat gtggtactga      720

gaggcagcct aactgaccac acagcattca tatttcatgt tgttattttc tctgatcctc      780

attatggctc ttcctgcggg tttgagtctt catttgggta atttagttat tctttgctgc      840

atttgattaa ggaaatacgt atatgggaat ttggagattt gtgactgact tcactatgtc      900

taattttttt ttgagacgga gttttgctct gttgcccagg ccggagtgca gtggcacagt      960

cttggctcac agcaacctct acctcctggg ttcaagcgat tctcctgcct tagcctcccg     1020

agtagctggg attacaggca tgtgccacca cgcctggcta atttttgtat ttttagtaga     1080

gacggggttt caccatggtg gccaggctgg gttctggttg tttatgatct ttatttttgg     1140

tgatctagga acggatcc                                                   1158


<210>  14
<211>  1158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3.OPTXonKGS Minigene

<400>  14
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatc ttggaaactt ttctggtaag ttctctcgtt accatctttt      120

gaaattttaa gtgaattaat acatatcttg cttagtctct tgtgcaggaa atgttttcca      180

tttatgacaa aacagttgtt ggtaaatgta aacaattcaa attatgagat gaggtgttaa      240

gttctggtgc attatctgtt acctatttca gatgcatttc ctagttcaca aattgtgtaa      300

tgattcttgt cagggcacac ttttcttggc tgcttaccta gtgtggtttg gtgcttgaag      360

agatagaact tttgtatgag agaaaaggga aaatgcagtt taggtaggga gtgctgtctg      420

catagaaaca gataatttgc ttacgtttac catgtgggga atatttttgt aaagatggat      480

taaggctagg tttgaattgt gtaaatttca aatattggat taggaaatac aaagttactg      540

aaagtgaggt actaatgttt ataaaataaa aactttttct tgccatttgc agatttaaca      600

tttttgagtc aatccaagta atgcaggagg gccaccatgg gtgtaccaga gtaagacata      660

attttgttga ggtttaactc tgaatactta tgtggtactg aatacttaat gtggtactga      720

gaggcagcct aactgaccac acagcattca tatttcatgt tgttattttc tctgatcctc      780

attatggctc ttcctgcggg tttgagtctt catttgggta atttagttat tctttgctgc      840

atttgattaa ggaaatacgt atatgggaat ttggagattt gtgactgact tcactatgtc      900

taattttttt ttgagacgga gttttgctct gttgcccagg ccggagtgca gtggcacagt      960

cttggctcac agcaacctct acctcctggg ttcaagcgat tctcctgcct tagcctcccg     1020

agtagctggg attacaggca tgtgccacca cgcctggcta atttttgtat ttttagtaga     1080

gacggggttt caccatggtg gccaggctgg gttctggttg tttatgatct ttatttttgg     1140

tgatctagga aaggatcc                                                   1158


<210>  15
<211>  1158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3.OPTXonRGS Minigene

<400>  15
aagcttggca atccggtact gttggtaaat ttctgtacaa cttaaccttg cagagagcca       60

ctggcatcag ctttgccatc ttggaaactt ttctggtaag ttctctcgtt accatctttt      120

gaaattttaa gtgaattaat acatatcttg cttagtctct tgtgcaggaa atgttttcca      180

tttatgacaa aacagttgtt ggtaaatgta aacaattcaa attatgagat gaggtgttaa      240

gttctggtgc attatctgtt acctatttca gatgcatttc ctagttcaca aattgtgtaa      300

tgattcttgt cagggcacac ttttcttggc tgcttaccta gtgtggtttg gtgcttgaag      360

agatagaact tttgtatgag agaaaaggga aaatgcagtt taggtaggga gtgctgtctg      420

catagaaaca gataatttgc ttacgtttac catgtgggga atatttttgt aaagatggat      480

taaggctagg tttgaattgt gtaaatttca aatattggat taggaaatac aaagttactg      540

aaagtgaggt actaatgttt ataaaataaa aactttttct tgccatttgc agatttaaca      600

tttttgagtc aatccaagta atgcaggagg gccaccatgg gtgtaccaga gtaagacata      660

attttgttga ggtttaactc tgaatactta tgtggtactg aatacttaat gtggtactga      720

gaggcagcct aactgaccac acagcattca tatttcatgt tgttattttc tctgatcctc      780

attatggctc ttcctgcggg tttgagtctt catttgggta atttagttat tctttgctgc      840

atttgattaa ggaaatacgt atatgggaat ttggagattt gtgactgact tcactatgtc      900

taattttttt ttgagacgga gttttgctct gttgcccagg ccggagtgca gtggcacagt      960

cttggctcac agcaacctct acctcctggg ttcaagcgat tctcctgcct tagcctcccg     1020

agtagctggg attacaggca tgtgccacca cgcctggcta atttttgtat ttttagtaga     1080

gacggggttt caccatggtg gccaggctgg gttctggttg tttatgatct ttatttttgg     1140

tgatctaggc gcggatcc                                                   1158


<210>  16
<211>  195
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SF3B3 Minigene sequence of FIG. 3F

<400>  16
agcttggcaa tccggtactg ttggtaaatt tctgtacaac ttaaccttgc agagagccac       60

tggcatcagc tttgccattc ttggaaactt ttctggaacc aaacaacaag aaattgttgt      120

ttcccgtggg taagaggatc cgaagatgcc aaaaacatta agaagggccc agcgccattc      180

tacccactcg aagac                                                       195


<210>  17
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acids encoded by SF3B3 Minigene sequence of FIG. 3F

<400>  17

Ser Leu Ala Ile Arg Tyr Cys Trp Ile Ser Val Gln Leu Asn Leu Ala 
1               5                   10                  15      


Glu Ser His Trp His Gln Leu Cys His Ser Trp Lys Leu Phe Trp Asn 
            20                  25                  30          


Gln Thr Thr Arg Asn Cys Cys Phe Pro Trp Val Arg Gly Ser Glu Asp 
        35                  40                  45              


Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
    50                  55                  60                  


<210>  18
<211>  203
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BENC1 Minigene sequence of FIG. 3F

<400>  18
aagcttggca atccggtact gttggtaaac tttcctggac tgtgtgcagc agttcaaaga       60

agaggttgag aaaggcgaga cacgtttttg tcttccctac aggatcgatg tggaaaaaaa      120

caagattgaa aacacaataa ccggatccga agatgccaaa aacattaaga agggcccagc      180

gccattctac ccactcgaag acg                                              203


<210>  19
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acids encoded by BENC1 Minigene sequence of FIG. 3F

<400>  19

Ser Leu Ala Ile Arg Tyr Cys Trp Thr Phe Leu Asp Cys Val Gln Gln 
1               5                   10                  15      


Phe Lys Glu Glu Val Glu Lys Gly Glu Thr Arg Phe Cys Leu Pro Tyr 
            20                  25                  30          


Arg Ile Asp Val Glu Lys Asn Lys Ile Glu Asn Thr Ile Thr Gly Ser 
        35                  40                  45              


Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu 
    50                  55                  60                  


Glu Asp 
65      


<210>  20
<211>  199
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PDXDC2 Minigene sequence of FIG. 3F

<400>  20
aagcttggca atccggtact gttggtaaac tcggcttgcc cttcccctgc ttgtgccgtg       60

taccctgtaa cactgtgttt cgatcccagc atcagatgga tcttgccttc ctggaaaaac      120

ttattaaaat tgatatataa cggagaagat gccaaaaaca ttaagaaggg cccagcgcca      180

ttctacccac tcgaagacg                                                   199


<210>  21
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>   Amino acids encoded by PDXDC2 Minigene sequence of FIG. 3F

<400>  21

Lys Leu Gly Asn Pro Val Leu Leu Val Asn Ser Ala Cys Pro Ser Pro 
1               5                   10                  15      


Ala Cys Ala Val Tyr Pro Val Thr Leu Cys Phe Asp Pro Ser Ile Arg 
            20                  25                  30          


Trp Ile Leu Pro Ser Trp Lys Asn Leu Leu Lys Leu Ile Tyr Asn Gly 
        35                  40                  45              


Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu 
    50                  55                  60                  


Glu Asp 
65      


<210>  22
<211>  230
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C12ORF4 Minigene sequence of FIG. 3F

<400>  22
aaagcttggc aatccggtac tgttggtaaa agtatgtcgg caagtcagct ggtttcccag       60

tgcaggacgc gctgacagct cgagtgagcg gactgcccag gacttcggaa ctagacgagt      120

tctgtacaaa tcctgtcaaa aaatatcaaa aaaaacagag aaagtaaccg gatccgaaga      180

tgccaaaaac attaagaagg gcccagcgcc attctaccca ctcgaagacg                 230


<210>  23
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acids encoded by C12ORF4 Minigene sequence of FIG. 3F

<400>  23

Lys Leu Gly Asn Pro Val Leu Leu Val Lys Val Cys Arg Gln Val Ser 
1               5                   10                  15      


Trp Phe Pro Ser Ala Gly Arg Ala Asp Ser Ser Ser Glu Arg Thr Ala 
            20                  25                  30          


Gln Asp Phe Gly Thr Arg Arg Val Leu Tyr Lys Ser Cys Gln Lys Ile 
        35                  40                  45              


Ser Lys Lys Thr Glu Lys Val Thr Gly Ser Glu Asp Ala Lys Asn Ile 
    50                  55                  60                  


Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
65                  70                  75      


<210>  24
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in SF3B3

<400>  24
agagtccgac                                                              10


<210>  25
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in BENC1

<400>  25
agagtaaggc                                                              10


<210>  26
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in GXYLT1

<400>  26
agagtatagt                                                              10


<210>  27
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in C12orf4, PDXDC2, and CIP2A

<400>  27
agagtaagaa                                                              10


<210>  28
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in RARS

<400>  28
agagtaggat                                                              10


<210>  29
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in WNK1

<400>  29
agagtaggtg                                                              10


<210>  30
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in WDR27

<400>  30
agagtaagca                                                              10


<210>  31
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMI070 Binding sequence in ITF57

<400>  31
agagtaggcc                                                              10
