                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Kalyanasundaram, Ramaswamy
 
<120>  Vaccine and Methods for Detecting and Preventing Filariasis

<130>  UIC0030WO.3

<150>  US 16/790,277
<151>  2020-02-13

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
cgcggatcca tggaagagaa ggtggtg                                           27


<210>  2
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
ccggaattct cacttgtcgt tggtg                                             25


<210>  3
<211>  12
<212>  PRT
<213>  Brugia malayi

<400>  3

Trp Ser Ala Glu Gln Trp Asp Trp Pro Leu Gln His 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Brugia malayi

<400>  4

Glu Val Ile Lys Thr Asn Thr Asn Asp Lys 
1               5                   10  


<210>  5
<211>  8
<212>  PRT
<213>  Brugia malayi

<400>  5

Ser Arg Ala Glu His Tyr Gly Glu 
1               5               


<210>  6
<211>  11
<212>  PRT
<213>  Brugia malayi

<400>  6

Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu 
1               5                   10      


<210>  7
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  7

Phe Thr Pro Lys Glu Ile Glu Val Lys 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Brugia malayi

<400>  8

Ile Glu Val Lys Val Ala Gly Asp 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Brugia malayi

<400>  9

Val Gly Leu Asp Ala Ser Phe Phe 
1               5               


<210>  10
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  10

Gly Leu Asp Ala Ser Phe Phe Thr Pro 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  11

Val Lys Val Ala Gly Asp Asn Leu Val 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  12

Lys Leu Pro Ser Asp Val Asp Thr Lys 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  13

Lys Thr Leu Thr Ser Asn Leu Thr Lys 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  14

Val Ile Lys Thr Asn Thr Asn Asp Lys 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  15

Asp Thr Lys Thr Leu Thr Ser Asn Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  16

Phe Phe Thr Pro Lys Glu Ile Glu Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  17

Val Gly Leu Asp Ala Ser Phe Phe Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  18

Lys Arg Gly His Leu Val Ile Ala Ala 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  19

Gly Glu Ile Lys Arg Glu Ile Ser Arg 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  20

Ser Phe Phe Thr Pro Lys Glu Ile Glu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  21

Arg Glu Ile Ser Arg Thr Tyr Lys Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  22

Gly Glu Ile Lys Arg Glu Ile Ser Arg 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Brugia malayi

<400>  23

Ala Glu His Tyr Gly Glu Ile Lys Arg 
1               5                   


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
ccggaattct cacttgtcgt tggtg                                             25


<210>  25
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  25
cgcggatcca ccgtgatcca ttgtcg                                            26


<210>  26
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
aactgcagct gttttccatt tccattc                                           27


<210>  27
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  27
aactgcagat gggtaacaag ctcctcatcg                                        30


<210>  28
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  28
cgcgaattcg gcgcactgcc aacctgc                                           27


<210>  29
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  29
cgcgaattca ccatggtcct ggag                                              24


<210>  30
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  30
gctctagatc agtccttctg gctag                                             25


<210>  31
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
cgggatccat ggaagaaaag gtagtg                                            26


<210>  32
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
ccctcgagtg ctttcttttt ggcagc                                            26


<210>  33
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
ccctcgagat gaataaactt ttaatagcat                                        30


<210>  34
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
gggtacccgc gcattgccaa ccc                                               23


<210>  35
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
ggggtacccc ggcaaggatc aatttaaaa                                         29


<210>  36
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
cggaattctc aatctttttg agatgaat                                          28


<210>  37
<211>  129
<212>  PRT
<213>  Brugia malayi

<400>  37

Met Gly Asn Lys Leu Leu Ile Ala Phe Gly Leu Val Ile Leu Phe Val 
1               5                   10                  15      


Thr Leu Pro Cys Val Ser Glu Ser Asp Glu Glu Phe Asp Asp Ser Ala 
            20                  25                  30          


Ala Asp Asp Thr Asp Asp Ser Glu Ala Gly Gly Gly Ser Glu Gly Gly 
        35                  40                  45              


Asp Glu Tyr Val Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys Lys 
    50                  55                  60                  


Lys Glu Cys Ser Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro Gln 
65                  70                  75                  80  


Ala Trp Cys Arg Leu Ser Glu Asn Gln Ala Trp Thr Asp Arg Gly Cys 
                85                  90                  95      


Phe Cys Glu Asp Lys Leu His Ser Cys Val Ile Glu Arg Thr Asn Asn 
            100                 105                 110         


Gly Lys Leu Glu Tyr Ser Tyr Cys Ala Pro Glu Ala Gly Trp Gln Cys 
        115                 120                 125             


Ala 
    


<210>  38
<211>  572
<212>  DNA
<213>  Brugia malayi

<400>  38
ggtttattac cccaagtttg agggaggaga aaatgaataa acttttaata gcattcggtt       60

tggtaattct ttttgtgaca ctcccgtgtg tatcagaatc agacgaagag ttcgatgact      120

ccgcagccga tgacaccgac gacagcgagg ccggaggtgg tagtgaagga ggtgatgaat      180

atgtaaccaa aggggaattt gttgaaactg atggcaaaaa gaaagagtgc tcttcgcacg      240

aagcttgcta cgatcaacgt gaaccacaag cgtggtgcag actgagcgag aatcaggcat      300

ggactgacag aggctgcttc tgcgaagata agttgcattc gtgcgtcatc gaaagaacga      360

acaatggtaa attggagtat tcgtactgtg cacctgaagc aggttggcaa tgcgcatagg      420

aatgaatcag tctttgatac taccaacttt ccatccattt cctacacttt tcaaatttaa      480

ttctttctaa caaataacat ttaactttgg ttttaccgtt attttattaa atattggaaa      540

tatgtgcgac aaaaaaaaaa aaaaaaaaaa aa                                    572


<210>  39
<211>  126
<212>  PRT
<213>  Brugia malayi

<400>  39

Met Asn Asn Leu Leu Ile Ala Ile Ser Leu Val Ile Leu Leu Val Ile 
1               5                   10                  15      


Phe Pro Ser Lys Ser Asp Leu Glu Ile Asp Asp Ser Ser Asp Ser Asp 
            20                  25                  30          


Tyr Ala His Ser Asn Asp Asp Asp Tyr Asn Glu Glu Glu Asp Glu Tyr 
        35                  40                  45              


Thr Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys Trp Lys Asn Cys 
    50                  55                  60                  


Ser Ser His Ala Asp Cys Tyr Asp Tyr Arg Glu Pro Ile Ala Trp Cys 
65                  70                  75                  80  


Lys Pro Thr Ala Asn Gln Phe Trp Thr Asp Lys Gly Cys Phe Cys Glu 
                85                  90                  95      


Asp Met Leu Tyr Ser Cys Val Ile Glu Arg Thr Asn Asn Gly Lys Leu 
            100                 105                 110         


Glu Tyr Ser Tyr Cys Thr Ser Lys Glu Asn Trp Gln Cys Leu 
        115                 120                 125     


<210>  40
<211>  381
<212>  DNA
<213>  Brugia malayi

<400>  40
atgaataatc tattgatagc aatcagttta gtaattcttc ttgtgatatt cccatcaaaa       60

tcagatttag aaattgatga ttcctcagac agtgattatg ctcatagcaa tgacgacgat      120

tacaatgaag aagaagatga atatacgacc aaaggagaat ttgttgaaac tgatggcaaa      180

tggaagaatt gcagttctca tgcagattgc tatgattatc gtgaaccaat agcttggtgc      240

aaacccactg caaatcaatt ttggacagac aaaggttgct tctgtgaaga tatgttgtat      300

tcatgtgtga tcgaaagaac gaacaatggc aaattagaat attcatattg tacatccaaa      360

gaaaactggc aatgtttata a                                                381


<210>  41
<211>  128
<212>  PRT
<213>  Wuchereria bancrofti

<400>  41

Met Asn Lys Leu Leu Ile Ala Phe Gly Leu Val Ile Leu Leu Val Thr 
1               5                   10                  15      


Leu Pro Cys Ala Ser Glu Ser Asp Glu Glu Phe Asp Asp Gly Ser Asn 
            20                  25                  30          


Asp Glu Thr Asp Asp Lys Glu Asp Glu Gly Asn Ser Glu Gly Gly Asp 
        35                  40                  45              


Glu Tyr Val Thr Lys Gly Glu Val Val Glu Thr Asp Gly Lys Lys Lys 
    50                  55                  60                  


Glu Cys Ser Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro Gln Ala 
65                  70                  75                  80  


Trp Cys Arg Pro Asn Glu Asn Gln Ser Trp Thr Asp Lys Gly Cys Phe 
                85                  90                  95      


Cys Glu Asp Lys Leu His Ser Cys Val Ile Glu Arg Lys Asn Asn Gly 
            100                 105                 110         


Lys Leu Glu Tyr Ser Tyr Cys Ala Pro Glu Ala Gly Trp Gln Cys Ala 
        115                 120                 125             


<210>  42
<211>  387
<212>  DNA
<213>  Wuchereria bancrofti

<400>  42
atgaataaac ttttaatagc attcggttta gtaattcttc ttgtgacact tccgtgtgca       60

tcagaatcag acgaagagtt cgatgacggc tcaaatgatg agaccgacga caaagaggac      120

gaaggtaata gtgaaggagg tgatgaatat gtaaccaaag gagaagttgt tgaaactgat      180

ggcaagaaga aagagtgctc ttcgcacgaa gcttgttacg atcaacgtga accacaagcg      240

tggtgtagac cgaacgagaa tcagtcgtgg actgacaaag gttgcttctg cgaagataag      300

ttgcattcgt gcgtcatcga aagaaagaac aacggtaaat tggagtattc gtattgcgca      360

cctgaagcgg gttggcaatg cgcgtag                                          387


<210>  43
<211>  83
<212>  PRT
<213>  Loa loa

<400>  43

Met Ile His Asn Gly Gly Tyr Gln Lys Leu Lys Val Lys Leu Arg Lys 
1               5                   10                  15      


Lys Glu Cys Lys Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro Gln 
            20                  25                  30          


Asp Trp Cys Arg Leu Asn Glu Asn Gln Ser Trp Thr Asp Lys Gly Cys 
        35                  40                  45              


Tyr Cys Asp Asp Lys Leu His Ser Cys Ile Ile Glu Arg Lys Asn Gly 
    50                  55                  60                  


Gly Lys Leu Glu Tyr Ala His Cys Ala Pro Glu Gln Gly Trp Lys Cys 
65                  70                  75                  80  


Pro Ser Lys 
            


<210>  44
<211>  252
<212>  DNA
<213>  Loa loa

<400>  44
atgattcata acggtggata ccaaaaatta aaagtcaaat tgaggaagaa agaatgcaag       60

tctcatgaag cttgctacga tcaacgtgaa ccacaagact ggtgcagatt gaacgaaaat      120

caatcgtgga cagacaaagg ttgctactgt gacgataagt tgcattcatg cattattgag      180

cgcaagaacg gtggcaagtt ggaatatgcg cactgtgcgc ctgaacaagg atggaaatgt      240

ccaagcaagt aa                                                          252


<210>  45
<211>  229
<212>  PRT
<213>  Brugia malayi

<400>  45

Met Val His Gly Cys Gly Asn Arg Thr Leu Lys Phe Leu Phe Phe Thr 
1               5                   10                  15      


Ala Asn Leu Leu Thr Cys Ala Phe Gly Ala Leu Leu Phe Gly Ile Ser 
            20                  25                  30          


Leu Trp Ala Tyr His Asp Glu Asn Phe Leu Gln Lys Leu Glu Lys Val 
        35                  40                  45              


Gln Glu Ile His Lys Glu Tyr Ser Pro Glu Leu Thr Gln His Gln Ile 
    50                  55                  60                  


Gly Leu Trp Leu Leu Ile Ile Ile Gly Ala Ser Ile Phe Leu Val Gly 
65                  70                  75                  80  


Phe Leu Gly Cys Cys Gly Ala Ile Cys Glu Ser Thr Lys Leu Leu Ala 
                85                  90                  95      


Leu Phe Ser Ile Ile Val Leu Ile Leu Ala Ile Leu Glu Val Ala Ser 
            100                 105                 110         


Ile Val Leu Ile Ile Ala Gly Lys Asp Gln Phe Lys Asn Ala Leu Tyr 
        115                 120                 125             


Asn Leu Leu Ser Lys Thr Gly Glu Ser Glu Asp Glu Met Gln His Phe 
    130                 135                 140                 


Lys Pro Ile Glu Asp Leu Phe Gln Cys Cys Gly Pro Thr Asn Glu Thr 
145                 150                 155                 160 


Met Val Arg Tyr Ile Glu Asn Gly Leu Cys Glu Asp Glu Leu Arg Asn 
                165                 170                 175     


Lys Pro Asn Cys Phe Ala Val Ile Ser Asp His Phe Asp Ser Ser Gln 
            180                 185                 190         


Lys Asp Ile Ile Lys Ile Ser Val Val Leu Ile Ile Ile Asp Leu Leu 
        195                 200                 205             


Ala Leu Phe Ser Thr Ser Met Leu Tyr Lys Ala Phe Arg Tyr Gln Thr 
    210                 215                 220                 


Pro Tyr Tyr Tyr Ala 
225                 


<210>  46
<211>  690
<212>  DNA
<213>  Brugia malayi

<400>  46
atggttcacg gctgtggtaa tcgaacattg aaatttttat ttttcactgc aaatttatta       60

acttgtgcat ttggtgcact tctttttggc atttcattat gggcttatca tgatgaaaat      120

tttttgcaaa aattagaaaa agtacaggaa atacataaag aatattctcc tgaactaaca      180

caacatcaaa taggattgtg gttattaata attattggtg catccatatt tcttgttggt      240

tttctcggtt gttgtggtgc gatatgtgaa agtaccaagc tattggcttt attttctatt      300

attgtattaa ttcttgcaat acttgaagtt gcttcgatag tacttataat tgctggcaag      360

gatcaattta aaaatgcttt atataattta ctatcaaaaa ctggcgaatc agaagatgaa      420

atgcaacatt ttaaacctat cgaagattta ttccaatgtt gtggtccaac aaatgaaaca      480

atggttcgat acatcgagaa tggcttatgt gaggatgaat taagaaataa accgaattgt      540

ttcgcagtaa tatccgatca ttttgattca tctcaaaaag atatcattaa aatttccgtc      600

gttttaataa ttattgattt gcttgcatta ttttctacat ctatgcttta taaagcattt      660

cgctatcaaa caccatacta ttatgcttaa                                       690


<210>  47
<211>  230
<212>  PRT
<213>  Loa loa

<400>  47

Met Val His Gly Cys Gly Asn Arg Met Val Lys Phe Leu Phe Phe Thr 
1               5                   10                  15      


Ala Asn Leu Leu Ile Cys Leu Phe Gly Ala Leu Ile Phe Gly Phe Ser 
            20                  25                  30          


Leu Trp Ala Asn Leu Asp Glu Asp Phe Ala Leu Lys Leu Glu Glu Thr 
        35                  40                  45              


Arg Lys Ile His Lys Glu Asp Phe Asn Val Leu Ala Arg Tyr Gln Ala 
    50                  55                  60                  


Ala Phe Trp Val Leu Val Val Ile Gly Ala Phe Leu Phe Leu Val Gly 
65                  70                  75                  80  


Phe Leu Gly Cys Cys Gly Ala Met Cys Glu Asn Ile Met Leu Leu Thr 
                85                  90                  95      


Ala Phe Phe Ile Ile Ile Leu Ile Leu Thr Thr Ile Glu Val Gly Ala 
            100                 105                 110         


Val Ile Phe Ala Ile Thr Ser Lys Gly Gln Phe Lys Ser Val Leu His 
        115                 120                 125             


Arg Leu Leu Ser Glu Ala Gly Lys Ala Glu Asp Lys Tyr Leu Pro Asn 
    130                 135                 140                 


Leu Lys Pro Ile Glu Asp Leu Phe Tyr Cys Cys Gly Ala Thr Gln Glu 
145                 150                 155                 160 


Thr Met Asn Arg Tyr Met Glu His Gly Leu Cys Glu Gly Glu Leu Lys 
                165                 170                 175     


Asn Lys Pro Asp Cys Phe Thr Ala Ile Ser Asp Tyr Leu Glu Ser Thr 
            180                 185                 190         


Gly Glu Ala Val Val Val Phe Ala Phe Phe Leu Leu Ile Ile Glu Leu 
        195                 200                 205             


Phe Ala Leu Val Ser Thr Cys Ile Leu Cys Lys Ala Phe Arg Tyr Gly 
    210                 215                 220                 


Arg Pro Tyr Tyr Tyr Ala 
225                 230 


<210>  48
<211>  693
<212>  DNA
<213>  Loa loa

<400>  48
atggttcacg gttgtggcaa tcgaatggtg aaatttttat ttttcactgc aaatttactg       60

atctgtttat ttggcgcact tatttttggc ttctcattat gggctaattt ggatgaagat      120

tttgcgctaa agctggaaga aacgagaaaa atacataaag aagattttaa tgtgctggca      180

agatatcaag cagcattttg ggtattggtt gttattgggg cattcttgtt tctcgttggt      240

ttcctcggct gttgtggtgc aatgtgtgaa aatatcatgt tgttgactgc atttttcatc      300

ataatactaa ttcttacaac aatcgaagtt ggcgcggtaa tatttgcaat cactagcaag      360

ggccaattta aaagtgtttt acataggcta ctatcagaag ctggtaaagc agaagacaaa      420

tacttgccga atttaaaacc catcgaagat ctgttttatt gctgtggtgc aacgcaagaa      480

acgatgaacc ggtacatgga acatggctta tgtgaaggag aattgaagaa taagccggac      540

tgcttcacgg caatatcgga ttatttggag tcaaccggag aagcggtcgt cgtatttgca      600

ttctttttgc taattatcga gttgtttgct ttagtttcca catgtatact atgtaaagca      660

ttccgttatg gaaggccata ctactatgct taa                                   693


<210>  49
<211>  113
<212>  PRT
<213>  Brugia malayi

<400>  49

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Glu Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Glu Val Ile Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Ala Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Ser Arg Ala Glu His Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala 
    


<210>  50
<211>  342
<212>  DNA
<213>  Brugia malayi

<400>  50
atggaagaaa aggtagtgga actaacgcac aactggagtg cggagcagtg ggattggccc       60

ttacagcaca acgatgaggt gattaaagta accaacacga atgataagtt tgaagtcggt      120

ttggatgcat cattcttcac gccgaaggaa atcgaggtaa aagttgctgg cgataatctg      180

gtcattcact gcagacatga atcacgtgcc gagcattatg gagaaattaa acgtgaaatt      240

agtcgtacct ataagcttcc gtcggatgta gatacgaaga ctctgacatc aaatttgacc      300

aagcgaggac atttggtcat cgctgccaaa aagaaagcat ga                         342


<210>  51
<211>  165
<212>  PRT
<213>  Onchocerca volvulus

<400>  51

Gln Thr Ser Pro Met Glu Arg Phe Ile Val Asn Leu Leu Asp Ser Thr 
1               5                   10                  15      


Phe Asp Asp Arg Ser Ser Arg Pro Leu His Ser Val Ala Pro Tyr Trp 
            20                  25                  30          


Leu His Gln Pro Glu Leu Asn Glu Cys Asn Ile Gly Asn Ser Leu Gly 
        35                  40                  45              


Glu Val Ile Asn Glu Lys Asp Lys Phe Ala Val Arg Ala Asp Val Ser 
    50                  55                  60                  


His Phe His Pro Lys Glu Leu Ser Val Ser Val Arg Asp Arg Glu Leu 
65                  70                  75                  80  


Val Ile Glu Gly His His Glu Glu Arg Thr Asp Pro Ala Gly His Gly 
                85                  90                  95      


Ser Ile Glu Arg His Phe Ile Arg Lys Tyr Val Leu Pro Glu Glu Val 
            100                 105                 110         


Gln Pro Asp Thr Ile Glu Ser His Leu Ser Asp Lys Gly Val Leu Thr 
        115                 120                 125             


Ile Ser Ala Asn Lys Thr Ala Ile Gly Thr Thr Ala Ser Arg Asn Ile 
    130                 135                 140                 


Pro Ile Arg Ala Ser Pro Lys Glu Pro Glu Ala Asn Gln Lys Ser Ala 
145                 150                 155                 160 


Ile Asn Asp Ala Lys 
                165 


<210>  52
<211>  574
<212>  DNA
<213>  Onchocerca volvulus

<400>  52
caaacttcac cgatggaacg tttcatagtg aaccttcttg acagtacatt cgatgacaga       60

tcatctcgac cgctccattc tgttgcacca tattggcttc atcaaccgga actgaatgaa      120

tgtaatatcg gaaattctct cggcgaggta ataaatgaga aagacaagtt tgcagttcga      180

gctgatgttt ctcatttcca tccgaaggaa ctttcggtgt cggttcgaga tcgtgaacta      240

gttattgaag gtcaccatga agagcgtacc gatccggcag gacatggtag tattgaacgt      300

cacttcattc gaaaatatgt cttgccagaa gaagtgcagc ctgacacgat cgaatcacat      360

ttgtccgata aaggagtgtt gacaattagc gcaaacaaaa cagctattgg cacgactgca      420

tcacgaaaca ttccaattcg agcatctcca aaagaaccgg aagcaaatca gaaatcggca      480

ataaatgatg caaagtaaaa agaagtagaa attccggata tatttcattc tttattttat      540

acgctttttt tttctttttt tgttcatttt aaag                                  574


<210>  53
<211>  113
<212>  PRT
<213>  Loa loa

<400>  53

Met Glu Glu Lys Val Leu Glu Leu Thr His Asn Trp Ser Ala Glu Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Asp Val Ile Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Ser Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Ala Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Ser Arg Ala Asp Gln Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Ile Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Thr Leu Thr Lys Arg Gly His Leu Val Ile Val Ala Lys Lys Lys 
            100                 105                 110         


Ala 
    


<210>  54
<211>  342
<212>  DNA
<213>  Loa loa

<400>  54
atggaagaaa aggtattgga actaacgcat aattggagtg ccgagcagtg ggattggccc       60

ttgcagcata acgatgacgt gattaaagtg accaatacga atgataagtt tgaagtcagt      120

ctggatgctt cattcttcac accgaaggaa atcgaggtga aagttgctgg tgataatctg      180

gtcattcact gcagacatga atcacgtgcc gaccaatacg gtgaaattaa acgtgaaatt      240

agtcgtacct ataagcttcc gtcggatatt gatacgaaga ccctgacatc aactttgacc      300

aaaagaggac atctggtcat cgttgccaaa aagaaggcat ga                         342


<210>  55
<211>  220
<212>  PRT
<213>  Brugia malayi

<400>  55

Met Leu Phe Phe Val Ile Phe Ser Ile Thr Ile Ala Val Val Ala Gly 
1               5                   10                  15      


Phe Glu Cys Pro Gly Gly Arg Leu Thr Pro Gln Gln Arg Lys Asp Ile 
            20                  25                  30          


Val Arg Gln Asn Asn Lys Phe Arg Ser Leu Leu Ile His Gly Lys Leu 
        35                  40                  45              


Lys Asn Arg Asn Gly Thr Tyr Met Pro Arg Gly Lys Asn Met Leu Leu 
    50                  55                  60                  


Leu Lys Trp Ser Cys Gln Leu Glu Asn Ser Ala Gln Arg Trp Ala Asn 
65                  70                  75                  80  


Gln Cys Val Phe Gly His Ser Pro Arg Asn Gln Arg Gln Gly Ile Gly 
                85                  90                  95      


Glu Asn Val Tyr Ala Tyr Trp Ser Ser Glu Ser Val Glu Lys Leu Arg 
            100                 105                 110         


Asn Thr Ala Gly Thr Glu Ala Gly Lys Ser Trp Trp Ser Glu Leu Pro 
        115                 120                 125             


Lys Leu Tyr Lys Gln Asn Pro Ser Asn Asn Leu Thr Asp Asp Val Ala 
    130                 135                 140                 


Arg Gln Gly Val Leu His Phe Thr Gln Met Ala Trp Gly Lys Thr His 
145                 150                 155                 160 


Lys Ile Gly Cys Gly Ile Ala Thr Asn Cys Asp Gly Gly Arg Thr Leu 
                165                 170                 175     


Ile Ala Ile Cys His Tyr Ser Pro Ala Gly Asn Met Leu Lys Glu Leu 
            180                 185                 190         


Ile Tyr Glu Leu Gly Glu Pro Cys Lys Thr Asp Ser Asp Cys Asn Thr 
        195                 200                 205             


Lys Lys Cys Ala Lys Lys Ser Gly Leu Cys Arg Lys 
    210                 215                 220 


<210>  56
<211>  897
<212>  DNA
<213>  Brugia malayi

<400>  56
gcacgagata ttttcaaagc taacagtata cattccacca aaaaactcgg caaaatgtta       60

tttttcgtta tattttccat cacgattgct gttgtggcag gttttgaatg tccaggaggt      120

cgactaacac cacagcaacg taaagatatc gttcgtcaga acaataaatt tcgttcatta      180

ctaattcatg gaaaacttaa aaataggaat ggtacatata tgccacgcgg caagaatatg      240

ttgctactga agtggagttg tcagttagaa aattctgcgc aaagatgggc aaatcaatgc      300

gtctttgggc actctccgag aaatcaaaga caaggaatcg gtgaaaatgt ctatgcctac      360

tggtcatcag aaagcgtcga aaagcttaga aataccgctg gtacggaagc cggcaaaagt      420

tggtggtcag aacttccgaa actgtacaaa cagaatcctt cgaacaatct gactgatgat      480

gttgccagac aaggtgtttt acatttcaca cagatggcct ggggtaaaac gcataaaatt      540

ggttgtggta tagcaacaaa ctgcgatggt ggtcgcacac tcatagctat ttgccattat      600

tcacccgctg gaaatatgct aaaagaactg atatatgagc ttggcgaacc atgcaaaacg      660

gatagcgatt gtaacacaaa gaaatgtgcc aaaaaatctg gattgtgtag aaaatgaaag      720

agagtttaaa gtttcacttt ttgcactctt aattttggtt ttatattata aaactgagaa      780

ttattacaaa catatttatt ggctattata agataaaaaa gttccttgaa attcttctca      840

aataaaattt ctctctgata aaagcatgaa acaaaaaaaa aaaaaaaaaa aaaaaaa         897


<210>  57
<211>  220
<212>  PRT
<213>  Wuchereria bancrofti

<400>  57

Met Leu Leu Phe Val Ile Phe Ser Ala Thr Ile Val Ala Val Ala Ala 
1               5                   10                  15      


Phe Glu Cys Pro Gly Gly Gln Leu Thr Pro Gln Gln Arg Lys Asp Ile 
            20                  25                  30          


Val Arg Gln Asn Asn Lys Phe Arg Ser Leu Leu Ile Arg Gly Lys Leu 
        35                  40                  45              


Lys Asn Arg Asn Gly Thr Tyr Met Pro Arg Gly Lys Asn Met Leu Gln 
    50                  55                  60                  


Leu Thr Trp Ser Cys Gln Leu Glu Asn Ser Ala Gln Arg Trp Ala Asn 
65                  70                  75                  80  


Gln Cys Val Phe Gly His Ser Pro Arg Asn Gln Arg Gln Gly Ile Gly 
                85                  90                  95      


Glu Asn Val Tyr Ala Tyr Trp Ser Ser Ala Ser Val Glu Asn Leu Arg 
            100                 105                 110         


Lys Thr Ala Gly Thr Glu Ala Gly Lys Ser Trp Trp Ser Glu Leu Pro 
        115                 120                 125             


Glu Leu Tyr Lys His Asn Pro Ser Asn Asn Leu Thr Asp Asp Val Ser 
    130                 135                 140                 


Arg Gln Gly Val Leu His Phe Thr Gln Met Ala Trp Gly Lys Thr His 
145                 150                 155                 160 


Lys Ile Gly Cys Gly Ile Ala Thr Asn Cys Asp Gly Gly Arg Thr Leu 
                165                 170                 175     


Ile Thr Ile Cys His Tyr Ser Pro Ala Gly Asn Ile Leu Lys Asn Leu 
            180                 185                 190         


Ile Tyr Glu Leu Gly Glu Pro Cys Lys Lys Asp Gly Asp Cys Asn Thr 
        195                 200                 205             


Lys Lys Cys Ala Lys Lys Ser Gly Leu Cys Arg Lys 
    210                 215                 220 


<210>  58
<211>  873
<212>  DNA
<213>  Wuchereria bancrofti

<400>  58
ggaattcggc acgagcgaca tcttctgtta tcaaatatat tttcaaagct aacagtgtac       60

attctgccag aaaatcccgc aaaatgttac ttttcgtcat attttctgca actattgttg      120

ctgtggcggc ttttgaatgt ccaggaggtc aactaacacc gcaacaacgt aaagatatcg      180

ttcgtcagaa caataaattt cgttcattac tgattcgtgg aaaacttaaa aataggaatg      240

gtacatatat gccacgcggc aagaatatgt tgcaactgac atggagttgt cagttagaaa      300

attctgcgca aagatgggca aatcagtgcg tctttggaca ctcaccgaga aatcaaagac      360

aaggaatcgg tgaaaatgtt tacgcttact ggtcgtcagc aagcgttgaa aatcttagaa      420

aaaccgctgg tacggaagcc ggcaaaagtt ggtggtcaga acttccggaa ctgtacaaac      480

acaatccttc gaacaatctg actgacgatg tttccaggca aggtgttttg catttcacac      540

agatggcttg gggtaaaacg cataaaattg gttgtggtat tgctacaaac tgtgatggtg      600

gtcgcacact cataactatt tgccattatt cgcccgctgg aaatatactg aaaaatctga      660

tatatgagct tggcgaaccg tgcaaaaagg atggcgattg taacacaaag aaatgtgcga      720

aaaaatctgg attgtgcaga aagtgaaaga atttgaagag tttcaccttc tcatttctaa      780

ttttggtttt gtatcataaa actgacaatt attacaaaca tatttattgg ctattatggg      840

ataaagaagt ttcttgaaaa aaaaaaaaaa aaa                                   873


<210>  59
<211>  220
<212>  PRT
<213>  Onchocerca volvulus

<400>  59

Met Ile Leu Phe Ile Ile Phe Pro Ala Ile Val Val Ala Val Thr Gly 
1               5                   10                  15      


Tyr Asn Cys Pro Gly Gly Lys Leu Thr Ala Leu Glu Arg Lys Lys Ile 
            20                  25                  30          


Val Gly Gln Asn Asn Lys Tyr Arg Ser Asp Leu Ile Asn Gly Lys Leu 
        35                  40                  45              


Lys Asn Arg Asn Gly Thr Tyr Met Pro Arg Gly Lys Asn Met Leu Glu 
    50                  55                  60                  


Leu Thr Trp Asp Cys Lys Leu Glu Ser Ser Ala Gln Arg Trp Ala Asn 
65                  70                  75                  80  


Gln Cys Ile Phe Gly His Ser Pro Arg Gln Gln Arg Glu Gly Val Gly 
                85                  90                  95      


Glu Asn Val Tyr Ala Tyr Trp Ser Ser Val Ser Val Glu Gly Leu Lys 
            100                 105                 110         


Lys Thr Ala Gly Thr Asp Ala Gly Lys Ser Trp Trp Ser Lys Leu Pro 
        115                 120                 125             


Lys Leu Tyr Glu Asn Asn Pro Ser Asn Asn Met Thr Trp Lys Val Ala 
    130                 135                 140                 


Gly Gln Gly Val Leu His Phe Thr Gln Met Ala Trp Gly Lys Thr Tyr 
145                 150                 155                 160 


Lys Ile Gly Cys Gly Val Ala Thr Gln Cys Asp Gly Gly Arg Thr Leu 
                165                 170                 175     


Ile Val Ile Cys His Tyr Ser Pro Gly Gly Asn Met Val Gly Glu Val 
            180                 185                 190         


Ile Tyr His Arg Gly Asn Pro Cys Lys Val Asp Lys Asp Cys Tyr Thr 
        195                 200                 205             


Lys Lys Cys Leu Ser Lys Ser Gly Leu Cys Arg Lys 
    210                 215                 220 


<210>  60
<211>  883
<212>  DNA
<213>  Onchocerca volvulus

<400>  60
gcattttcta aagtgacatc ttctgttatt atcaaatata tttctgagat taacagctta       60

tattctatcg gaaaattccg caaaatgata cttttcatca tcttccctgc aattgtcgtc      120

gcggtgacgg gttataattg tccaggaggt aaactaacag cactggaacg taaaaaaatc      180

gttggtcaga ataataaata tcgttcggat ttgattaatg gaaagcttaa gaatagaaat      240

ggtacataca tgccaagagg caagaatatg ttggaactga catgggattg taaattggaa      300

agttcggcac aaaggtgggc caatcagtgt atctttggac attcaccaag acaacaaaga      360

gagggagttg gtgaaaatgt ttatgcgtac tggtcatcag tatcagttga aggtcttaaa      420

aaaactgctg gtacggatgc tgggaaaagc tggtggtcaa agcttccaaa attatatgaa      480

aataaccctt cgaataatat gacttggaaa gttgccggtc aaggtgtttt gcatttcaca      540

caaatggctt ggggtaagac ttataaaatt ggttgcggtg ttgcaacaca atgtgatggt      600

ggtagaacac ttattgttat ttgtcactat tctcctggtg gaaatatggt tggagaggtg      660

atataccacc gaggtaatcc gtgtaaagtc gacaaagatt gctatacgaa aaaatgttta      720

tcaaaatctg gactgtgcag aaaatgaaaa tttttcgctt ttcttcattt aattctcggc      780

tatatatctc ctatattaat ttttcagcaa aaaagctata aagaaatatt cataattaaa      840

taaatatagt aattattatg aaataaaaaa ttaagttctg ctc                        883


<210>  61
<211>  220
<212>  PRT
<213>  Loa loa

<400>  61

Met Leu Cys Ser Phe Met Phe Ala Ala Ile Ile Ile Ala Val Glu Gly 
1               5                   10                  15      


Tyr Arg Cys Gln Gly Gly Arg Leu Thr Pro Glu Gln Arg Lys Ala Ile 
            20                  25                  30          


Val Ile Gln Asn Asn Lys Phe Arg Ser Gln Leu Ile Arg Gly Glu Leu 
        35                  40                  45              


Lys Asn Lys Ala Gly Glu Phe Met Pro Arg Gly Lys Asn Met Leu Arg 
    50                  55                  60                  


Met Arg Trp Ser Cys Ser Leu Glu Tyr Ser Ala Gln Arg Trp Ala Asp 
65                  70                  75                  80  


Arg Cys Ile Phe Gly His Ser Pro Arg Asp Gln Arg Asn Asn Ile Gly 
                85                  90                  95      


Glu Asn Val Tyr Ala Tyr Trp Ser Ser Gly Ser Val Glu Gly His Arg 
            100                 105                 110         


Lys Thr Ala Gly Thr Asp Ala Gly Lys Asn Trp Trp Ser Glu Leu Pro 
        115                 120                 125             


Glu Arg Tyr Gly Ser Asn Pro Ser Asn Asn Leu Thr Ala Gln Val Ser 
    130                 135                 140                 


Ser Gln Gly Val Leu His Phe Thr Gln Met Ala Trp Gly Lys Thr Tyr 
145                 150                 155                 160 


Lys Ile Gly Cys Gly Ile Ala Thr Asn Cys Asp Gly Gly Arg Thr Leu 
                165                 170                 175     


Met Val Ile Cys His Tyr Ser Pro Ala Gly Asn Met Leu Lys Glu Leu 
            180                 185                 190         


Ile Tyr Glu Leu Gly Glu Pro Cys Lys Lys Asn Asn Asp Cys Tyr Thr 
        195                 200                 205             


Lys Lys Cys Ser Val Lys Ser Gly Leu Cys Asn Lys 
    210                 215                 220 


<210>  62
<211>  663
<212>  DNA
<213>  Loa loa

<400>  62
atgttatgtt ccttcatgtt tgcagcaatt atcattgctg tggaaggtta tcgatgtcaa       60

ggaggtcgac taacaccgga gcaacgtaaa gcaatcgtta ttcaaaataa taaattccgt      120

tcgcaactga tccgtggcga gcttaagaac aaagctggtg aatttatgcc acgtggcaag      180

aatatgttga gaatgagatg gagttgttcg ctggaatatt ccgcgcagag atgggcagat      240

agatgtatct ttggacactc accaagagat caaagaaaca atatcggtga aaatgtctat      300

gcttactggt catcaggaag cgttgaaggt catagaaaaa ctgctggtac agatgctggt      360

aaaaattggt ggtcagaact tccggaacgg tacggatcta atccttcaaa taatttgact      420

gctcaagttt ccagccaagg tgttttgcat ttcacacaga tggcttgggg taaaacgtac      480

aaaattggct gtggtattgc tacaaactgc gatggtggca ggacactaat ggtcatttgc      540

cattattcgc cagctgggaa tatgttgaaa gagcttatat atgagcttgg cgaaccatgc      600

aagaagaaca atgattgtta taccaagaag tgttcagtca agtctggatt gtgcaacaag      660

tga                                                                    663


<210>  63
<211>  89
<212>  PRT
<213>  Brugia malayi

<400>  63

Met Ile Leu Glu Val Ala Ser Ile Val Leu Ile Ile Ala Gly Lys Asp 
1               5                   10                  15      


Gln Phe Lys Asn Ala Leu Tyr Asn Leu Leu Ser Lys Thr Gly Glu Ser 
            20                  25                  30          


Glu Asp Glu Met Gln His Phe Lys Pro Ile Glu Asp Leu Phe Gln Cys 
        35                  40                  45              


Cys Gly Pro Thr Asn Glu Thr Met Val Arg Tyr Ile Glu Asn Gly Leu 
    50                  55                  60                  


Cys Glu Asp Glu Leu Arg Asn Lys Pro Asn Cys Phe Ala Val Ile Ser 
65                  70                  75                  80  


Asp His Phe Asp Ser Ser Gln Lys Asp 
                85                  


<210>  64
<211>  53
<212>  PRT
<213>  Brugia malayi

<400>  64

Val Ile His Cys Arg His Glu Ser Arg Ala Glu His Tyr Gly Glu Ile 
1               5                   10                  15      


Lys Arg Glu Ile Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr 
            20                  25                  30          


Lys Thr Leu Thr Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala 
        35                  40                  45              


Ala Lys Lys Lys Ala 
    50              


<210>  65
<211>  267
<212>  DNA
<213>  Brugia malayi

<400>  65
atgatcctgg aggtggcctc catcgtgctg atcatcgccg gcaaggacca gttcaagaac       60

gctctgtaca acctgctgtc taagacaggc gagagcgagg acgagatgca gcacttcaag      120

cctatcgagg acctgttcca gtgctgcggc cctaccaacg agaccatggt gaggtacatc      180

gagaacggac tgtgcgagga cgagctgagg aacaagccta actgtttcgc cgtgatctct      240

gaccacttcg attctagcca gaaggac                                          267


<210>  66
<211>  162
<212>  DNA
<213>  Brugia malayi

<400>  66
gtcattcact gcagacatga atcacgtgcc gagcattatg gagaaattaa acgtgaaatt       60

agtcgtacct ataagcttcc gtcggatgta gatacgaaga ctctgacatc aaatttgacc      120

aagcgaggac atttggtcat cgctgccaaa aagaaagcat ga                         162


<210>  67
<211>  387
<212>  DNA
<213>  Brugia malayi

<400>  67
atgggtaaca agctcctcat cgctttcgga ctcgtgatcc tgtttgtcac cctgccttgc       60

gtcagtgaga gcgacgagga gtttgatgac tctgccgctg acgacaccga cgattccgag      120

gccggtggcg gctctgaggg gggcgacgag tacgtgacta agggggagtt tgtggagacc      180

gatggaaaga agaaagagtg ctccagccac gaggcctgtt atgaccagcg ggagcctcag      240

gcttggtgca ggctgtctga gaatcaggcc tggactgata gaggctgttt ctgtgaggac      300

aagctgcatt cttgcgtgat tgagcggact aataatggca agctggaata cagctactgc      360

gctcccgagg caggttggca gtgcgcc                                          387


<210>  68
<211>  153
<212>  DNA
<213>  Wuchereria bancrofti

<400>  68
atggtcattc actgcaggca cgagagcaga gccgagcact acggcgagat caaaagagag       60

atcagcagga catacaagct gccctcagac gtggacacta agactctgac tagcaatctg      120

accaagaggg gccacctggt catcgctgcc aag                                   153


<210>  69
<211>  267
<212>  DNA
<213>  Wuchereria bancrofti

<400>  69
atgatcctgg aggtggcctc catcgtgctg atcatcgccg gcaaggacca gttcaagaac       60

gctctgtaca acctgctgtc taagacaggc gagagcgagg acgagatgca gcacttcaag      120

cctatcgagg acctgttcca gtgctgcggc cctaccaacg agaccatggt gaggtacatc      180

gagaacggac tgtgcgagga cgagctgagg aacaagccta actgtttcgc cgtgatctct      240

gaccacttcg attctagcca gaaggac                                          267


<210>  70
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Glu Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Glu Val Ile Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Ala Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Ser Arg Ala Glu His Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala Met Gly Asn Lys Leu Leu Ile Ala Phe Gly Leu Val Ile Leu Phe 
        115                 120                 125             


Val Thr Leu Pro Cys Val Ser Glu Ser Asp Glu Glu Phe Asp Asp Ser 
    130                 135                 140                 


Ala Ala Asp Asp Thr Asp Asp Ser Glu Ala Gly Gly Gly Ser Glu Gly 
145                 150                 155                 160 


Gly Asp Glu Tyr Val Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys 
                165                 170                 175     


Lys Lys Glu Cys Ser Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro 
            180                 185                 190         


Gln Ala Trp Cys Arg Leu Ser Glu Asn Gln Ala Trp Thr Asp Arg Gly 
        195                 200                 205             


Cys Phe Cys Glu Asp Lys Leu His Ser Cys Val Ile Glu Arg Thr Asn 
    210                 215                 220                 


Asn Gly Lys Leu Glu Tyr Ser Tyr Cys Ala Pro Glu Ala Gly Trp Gln 
225                 230                 235                 240 


Cys Ala Met Ile Leu Glu Val Ala Ser Ile Val Leu Ile Ile Ala Gly 
                245                 250                 255     


Lys Asp Gln Phe Lys Asn Ala Leu Tyr Asn Leu Leu Ser Lys Thr Gly 
            260                 265                 270         


Glu Ser Glu Asp Glu Met Gln His Phe Lys Pro Ile Glu Asp Leu Phe 
        275                 280                 285             


Gln Cys Cys Gly Pro Thr Asn Glu Thr Met Val Arg Tyr Ile Glu Asn 
    290                 295                 300                 


Gly Leu Cys Glu Asp Glu Leu Arg Asn Lys Pro Asn Cys Phe Ala Val 
305                 310                 315                 320 


Ile Ser Asp His Phe Asp Ser Ser Gln Lys Asp 
                325                 330     


<210>  71
<211>  199
<212>  PRT
<213>  Brugia malayi

<400>  71

Met Thr Leu Ala Gly Ser Lys Ala Phe Ile Gly Gln Pro Ala Pro Asn 
1               5                   10                  15      


Phe Lys Thr Thr Ala Val Val Asn Gly Asp Phe Lys Glu Ile Ser Leu 
            20                  25                  30          


Gly Gln Phe Lys Gly Lys Tyr Val Val Leu Leu Phe Tyr Pro Leu Asp 
        35                  40                  45              


Phe Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ile 
    50                  55                  60                  


Ala Glu Phe Lys Gln Leu Asp Val Ala Val Met Ala Cys Ser Thr Asp 
65                  70                  75                  80  


Ser His Phe Ser His Leu Ala Trp Val Asn Thr Asp Arg Lys Met Gly 
                85                  90                  95      


Gly Leu Gly Gln Met Asn Ile Pro Ile Leu Ala Tyr Thr Asn His Val 
            100                 105                 110         


Ile Ser Arg Ala Tyr Gly Val Leu Lys Glu Asp Asp Gly Ile Ala Tyr 
        115                 120                 125             


Arg Gly Leu Phe Ile Ile Asp Pro Lys Gly Ile Leu Gly Gln Ile Thr 
    130                 135                 140                 


Ile Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu 
145                 150                 155                 160 


Ile Gln Ala Phe Gln Phe Val Asp Lys His Gly Glu Val Cys Pro Ala 
                165                 170                 175     


Asn Trp His Pro Gly Ser Glu Thr Ile Lys Pro Gly Val Lys Glu Ser 
            180                 185                 190         


Lys Ala Tyr Phe Glu Lys His 
        195                 


<210>  72
<211>  713
<212>  DNA
<213>  Brugia malayi

<400>  72
ggtttaatta cccaagtttg aggaagaaaa gaaaatgaca cttgctggaa gtaaagcatt       60

tattggtcaa ccagcaccta attttaaaac aacagctgtt gtgaacggtg atttcaagga      120

aatttcactt ggtcaattta agggaaaata tgttgttctc ctcttttatc ctcttgattt      180

cacttttgtt tgtccaacgg aaataattgc attttctgat cgtattgcgg aatttaaaca      240

attagatgta gctgttatgg catgttcaac agattcacac ttttcacatc ttgcatgggt      300

aaatactgat cgaaaaatgg gtggacttgg tcaaatgaat ataccaattt tggcttatac      360

aaatcatgta ataagtcgag catatggtgt acttaaagag gatgatggaa ttgcttatcg      420

tggattattc attattgatc caaaaggaat tttggggcaa atcacaatta acgatcttcc      480

agtagggcgt tctgtagacg aaactttacg tttaattcaa gcttttcagt ttgttgacaa      540

gcatggtgaa gtatgtcctg ctaattggca tccaggatct gaaacgatta agcctggtgt      600

gaaagaaagt aaagcatatt ttgagaaaca ttaaaaacca aaaatggttg tacgacatgg      660

aattactcag tggatttttt tgattaaatt atatgctgaa gtaatattaa cca             713


<210>  73
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Glu Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Glu Val Ile Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Ala Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Ser Arg Ala Glu His Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala Met Gly Asn Lys Leu Leu Ile Ala Phe Gly Leu Val Ile Leu Phe 
        115                 120                 125             


Val Thr Leu Pro Cys Val Ser Glu Ser Asp Glu Glu Phe Asp Asp Ser 
    130                 135                 140                 


Ala Ala Asp Asp Thr Asp Asp Ser Glu Ala Gly Gly Gly Ser Glu Gly 
145                 150                 155                 160 


Gly Asp Glu Tyr Val Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys 
                165                 170                 175     


Lys Lys Glu Cys Ser Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro 
            180                 185                 190         


Gln Ala Trp Cys Arg Leu Ser Glu Asn Gln Ala Trp Thr Asp Arg Gly 
        195                 200                 205             


Cys Phe Cys Glu Asp Lys Leu His Ser Cys Val Ile Glu Arg Thr Asn 
    210                 215                 220                 


Asn Gly Lys Leu Glu Tyr Ser Tyr Cys Ala Pro Glu Ala Gly Trp Gln 
225                 230                 235                 240 


Cys Ala Met Thr Leu Ala Gly Ser Lys Ala Phe Ile Gly Gln Pro Ala 
                245                 250                 255     


Pro Asn Phe Lys Thr Thr Ala Val Val Asn Gly Asp Phe Lys Glu Ile 
            260                 265                 270         


Ser Leu Gly Gln Phe Lys Gly Lys Tyr Val Val Leu Leu Phe Tyr Pro 
        275                 280                 285             


Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp 
    290                 295                 300                 


Arg Ile Ala Glu Phe Lys Gln Leu Asp Val Ala Val Met Ala Cys Ser 
305                 310                 315                 320 


Thr Asp Ser His Phe Ser His Leu Ala Trp Val Asn Thr Asp Arg Lys 
                325                 330                 335     


Met Gly Gly Leu Gly Gln Met Asn Ile Pro Ile Leu Ala Tyr Thr Asn 
            340                 345                 350         


His Val Ile Ser Arg Ala Tyr Gly Val Leu Lys Glu Asp Asp Gly Ile 
        355                 360                 365             


Ala Tyr Arg Gly Leu Phe Ile Ile Asp Pro Lys Gly Ile Leu Gly Gln 
    370                 375                 380                 


Ile Thr Ile Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu 
385                 390                 395                 400 


Arg Leu Ile Gln Ala Phe Gln Phe Val Asp Lys His Gly Glu Val Cys 
                405                 410                 415     


Pro Ala Asn Trp His Pro Gly Ser Glu Thr Ile Lys Pro Gly Val Lys 
            420                 425                 430         


Glu Ser Lys Ala Tyr Phe Glu Lys His 
        435                 440     


<210>  74
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Glu Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Glu Val Ile Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Ala Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Ser Arg Ala Glu His Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala Met Gly Asn Lys Leu Leu Ile Ala Phe Gly Leu Val Ile Leu Phe 
        115                 120                 125             


Val Thr Leu Pro Cys Val Ser Glu Ser Asp Glu Glu Phe Asp Asp Ser 
    130                 135                 140                 


Ala Ala Asp Asp Thr Asp Asp Ser Glu Ala Gly Gly Gly Ser Glu Gly 
145                 150                 155                 160 


Gly Asp Glu Tyr Val Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys 
                165                 170                 175     


Lys Lys Glu Cys Ser Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro 
            180                 185                 190         


Gln Ala Trp Cys Arg Leu Ser Glu Asn Gln Ala Trp Thr Asp Arg Gly 
        195                 200                 205             


Cys Phe Cys Glu Asp Lys Leu His Ser Cys Val Ile Glu Arg Thr Asn 
    210                 215                 220                 


Asn Gly Lys Leu Glu Tyr Ser Tyr Cys Ala Pro Glu Ala Gly Trp Gln 
225                 230                 235                 240 


Cys Ala Met Thr Leu Ala Gly Ser Lys Ala Phe Ile Gly Gln Pro Ala 
                245                 250                 255     


Pro Asn Phe Lys Thr Thr Ala Val Val Asn Gly Asp Phe Lys Glu Ile 
            260                 265                 270         


Ser Leu Gly Gln Phe Lys Gly Lys Tyr Val Val Leu Leu Phe Tyr Pro 
        275                 280                 285             


Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp 
    290                 295                 300                 


Arg Ile Ala Glu Phe Lys Gln Leu Asp Val Ala Val Met Ala Cys Ser 
305                 310                 315                 320 


Thr Asp Ser His Phe Ser His Leu Ala Trp Val Asn Thr Asp Arg Lys 
                325                 330                 335     


Met Gly Gly Leu Gly Gln Met Asn Ile Pro Ile Leu Ala Tyr Thr Asn 
            340                 345                 350         


His Val Ile Ser Arg Ala Tyr Gly Val Leu Lys Glu Asp Asp Gly Ile 
        355                 360                 365             


Ala Tyr Arg Gly Leu Phe Ile Ile Asp Pro Lys Gly Ile Leu Gly Gln 
    370                 375                 380                 


Ile Thr Ile Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu 
385                 390                 395                 400 


Arg Leu Ile Gln Ala Phe Gln Phe Val Asp Lys His Gly Glu Val Cys 
                405                 410                 415     


Pro Ala Asn Trp His Pro Gly Ser Glu Thr Ile Lys Pro Gly Val Lys 
            420                 425                 430         


Glu Ser Lys Ala Tyr Phe Glu Lys His Met Ile Leu Glu Val Ala Ser 
        435                 440                 445             


Ile Val Leu Ile Ile Ala Gly Lys Asp Gln Phe Lys Asn Ala Leu Tyr 
    450                 455                 460                 


Asn Leu Leu Ser Lys Thr Gly Glu Ser Glu Asp Glu Met Gln His Phe 
465                 470                 475                 480 


Lys Pro Ile Glu Asp Leu Phe Gln Cys Cys Gly Pro Thr Asn Glu Thr 
                485                 490                 495     


Met Val Arg Tyr Ile Glu Asn Gly Leu Cys Glu Asp Glu Leu Arg Asn 
            500                 505                 510         


Lys Pro Asn Cys Phe Ala Val Ile Ser Asp His Phe Asp Ser Ser Gln 
        515                 520                 525             


Lys Asp 
    530 


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  75
gcgcataaat tcatcagc                                                     18


<210>  76
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  76
gcgcaaaact taattacaaa agc                                               23


<210>  77
<211>  76
<212>  PRT
<213>  Brugia malayi

<400>  77

Gly Lys Asp Gln Phe Lys Asn Ala Leu Tyr Asn Leu Leu Ser Lys Thr 
1               5                   10                  15      


Gly Glu Ser Glu Asp Glu Met Gln His Phe Lys Pro Ile Glu Asp Leu 
            20                  25                  30          


Phe Gln Cys Cys Gly Pro Thr Asn Glu Thr Met Val Arg Tyr Ile Glu 
        35                  40                  45              


Asn Gly Leu Cys Glu Asp Glu Leu Arg Asn Lys Pro Asn Cys Phe Ala 
    50                  55                  60                  


Val Ile Ser Asp His Phe Asp Ser Ser Gln Lys Asp 
65                  70                  75      


<210>  78
<211>  33
<212>  PRT
<213>  Brugia malayi

<400>  78

Val Ser Glu Ser Asp Glu Glu Phe Asp Asp Ser Ala Ala Asp Asp Thr 
1               5                   10                  15      


Asp Asp Ser Glu Ala Gly Gly Gly Ser Glu Gly Gly Asp Glu Tyr Val 
            20                  25                  30          


Thr 
    


<210>  79
<211>  25
<212>  PRT
<213>  Brugia malayi

<400>  79

Glu Phe Val Glu Thr Asp Gly Lys Lys Lys Glu Cys Ser Ser His Glu 
1               5                   10                  15      


Ala Cys Tyr Asp Gln Arg Glu Pro Gln 
            20                  25  


<210>  80
<211>  12
<212>  PRT
<213>  Brugia malayi

<400>  80

Trp Ser Ala Glu Gln Trp Asp Trp Pro Leu Gln His 
1               5                   10          


<210>  81
<211>  11
<212>  PRT
<213>  Brugia malayi

<400>  81

Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu 
1               5                   10      


<210>  82
<211>  10
<212>  PRT
<213>  Brugia malayi

<400>  82

Lys Thr Gly Glu Ser Glu Asp Glu Met Gln 
1               5                   10  


<210>  83
<211>  11
<212>  PRT
<213>  Brugia malayi

<400>  83

Phe Ile Gly Gln Pro Ala Pro Asn Phe Lys Thr 
1               5                   10      


<210>  84
<211>  24
<212>  PRT
<213>  Brugia malayi

<400>  84

Gly Glu Val Cys Pro Ala Asn Trp His Pro Gly Ser Glu Thr Ile Lys 
1               5                   10                  15      


Pro Gly Val Lys Glu Ser Lys Ala 
            20                  


<210>  85
<211>  208
<212>  PRT
<213>  Wuchereria bancrofti

<400>  85

Met Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly Leu Ala Glu Pro 
1               5                   10                  15      


Ile Arg Leu Val Leu Val Asp Gln Gly Ile Lys Phe Thr Asp Asp Arg 
            20                  25                  30          


Ile Asn Ala Ser Asp Trp Pro Ser Met Lys Ser His Phe His Phe Gly 
        35                  40                  45              


Gln Leu Pro Cys Leu Tyr Asp Gly Asp His Gln Ile Val Gln Ser Gly 
    50                  55                  60                  


Ala Ile Leu Arg His Leu Ala Arg Lys His Asn Leu Asn Gly Gly Asn 
65                  70                  75                  80  


Glu Leu Glu Thr Thr His Ile Asp Met Phe Cys Glu Gly Ile Arg Asp 
                85                  90                  95      


Leu His Thr Lys Tyr Ala Lys Met Ile Tyr Gln Ala Tyr Asp Thr Glu 
            100                 105                 110         


Lys Asp Ser Tyr Ile Lys Asp Ile Leu Pro Val Glu Leu Ala Lys Phe 
        115                 120                 125             


Glu Lys Leu Leu Ala Thr Arg Asp Asp Gly Lys Asn Phe Ile Leu Gly 
    130                 135                 140                 


Glu Lys Ile Ser Tyr Val Asp Phe Val Leu Phe Glu Glu Leu Asp Ile 
145                 150                 155                 160 


His Gln Ile Leu Asp Pro His Cys Leu Asp Lys Phe Pro Leu Leu Lys 
                165                 170                 175     


Ala Tyr His Gln Arg Met Glu Asp Arg Pro Gly Leu Lys Glu Tyr Cys 
            180                 185                 190         


Lys Gln Arg Asn Arg Ala Lys Ile Pro Val Asn Gly Asn Gly Lys Gln 
        195                 200                 205             


<210>  86
<211>  627
<212>  DNA
<213>  Wuchereria bancrofti

<400>  86
atgagttata aactgacgta ttttcctatc cgaggcttgg ctgaaccaat tcgtttagta       60

ctggttgatc aaggtataaa gtttactgat gatcgtatca atgcaagtga ttggccttct      120

atgaaatcac actttcattt tggacaacta ccttgtcttt acgatggtga tcatcaaatt      180

gtgcagtccg gtgctattct gagacatctt gctcgcaaac ataatttaaa tggtggaaat      240

gaactggaaa cgacacatat tgatatgttc tgtgaaggca tccgtgatct acataccaaa      300

tatgcaaaaa tgatttacca ggcttatgac acagaaaagg attcctacat aaaggatata      360

ttgccagtag agctggcgaa atttgaaaag ttgcttgcta cacgagacga tggaaaaaat      420

ttcattctag gagaaaagat ttcatacgta gatttcgtcc ttttcgaaga acttgacatt      480

catcagatcc tggatccgca ctgcttggat aaatttccac tcttaaaagc ttaccatcaa      540

cgaatggaag atagacctgg acttaaggag tactgcaagc agcgtaatag agcaaaaata      600

ccagtgaatg gaaatggaaa acagtga                                          627


<210>  87
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  87
attttcggcc gtaggc                                                       16


<210>  88
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  88
aggtggccat tgacatgat                                                    19


<210>  89
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  89
cccgaattct taatgtttct caaaatatgc ttt                                    33


<210>  90
<211>  342
<212>  DNA
<213>  Dirofilaria immitis

<400>  90
atggaagaga aagtagtgga actaacgcat aattggagtg ccgatcagtg ggattggcct       60

ttacagcata atgatgatgt ggttaaagtg accaatacga atgataagtt tgaagtaggt      120

ttggacgcat cattctttac gccgaaggaa atcgaggtga aggtttgtgg cgataatttg      180

gttattcact gtagacatga aacacgcact gatcaatatg gtgaaattaa acgtgaaatt      240

agtcgcactt ataaactccc atcggatgta gatacaaaga cattaacatc aaatttgact      300

aaacgaggac atctggttat tgctgccaaa aagaaggcat aa                         342


<210>  91
<211>  113
<212>  PRT
<213>  Dirofilaria immitis

<400>  91

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Asp Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Asp Val Val Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Cys Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Thr Arg Thr Asp Gln Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Ile Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala 
    


<210>  92
<211>  453
<212>  DNA
<213>  Dirofilaria immitis

<400>  92
atgaacaaac ttttcatagt tcttggctta gcgcttcttt ttgttgcatt accttccgca       60

tcagaatcac aagaagagac tgtatctttt gaagaaagcg acgaagatta tgaagacgat      120

agtgaagatc aaacaaaaga agaggaacat tcaaaagagg aagatcattc agaagaacac      180

gacgatcatt cagctgaaga cgataaattt gtaactaaag gaaaatttgt tgaaagtgac      240

ggcaagatga agcattgcaa aacccatgaa gcttgctatg atcaacgtga accacaatcg      300

tggtgcatat taaaaccgca tcagtcatgg acacaaagag gttgtttctg cgaatcaaaa      360

aaacatgcat gcgttatcga acgaaaaagt ggcgacaaat tggaatattc gtattgctca      420

ccccgaaaaa actggcagtg ttcatacgat taa                                   453


<210>  93
<211>  150
<212>  PRT
<213>  Dirofilaria immitis

<400>  93

Met Asn Lys Leu Phe Ile Val Leu Gly Leu Ala Leu Leu Phe Val Ala 
1               5                   10                  15      


Leu Pro Ser Ala Ser Glu Ser Gln Glu Glu Thr Val Ser Phe Glu Glu 
            20                  25                  30          


Ser Asp Glu Asp Tyr Glu Asp Asp Ser Glu Asp Gln Thr Lys Glu Glu 
        35                  40                  45              


Glu His Ser Lys Glu Glu Asp His Ser Glu Glu His Asp Asp His Ser 
    50                  55                  60                  


Ala Glu Asp Asp Lys Phe Val Thr Lys Gly Lys Phe Val Glu Ser Asp 
65                  70                  75                  80  


Gly Lys Met Lys His Cys Lys Thr His Glu Ala Cys Tyr Asp Gln Arg 
                85                  90                  95      


Glu Pro Gln Ser Trp Cys Ile Leu Lys Pro His Gln Ser Trp Thr Gln 
            100                 105                 110         


Arg Gly Cys Phe Cys Glu Ser Lys Lys His Ala Cys Val Ile Glu Arg 
        115                 120                 125             


Lys Ser Gly Asp Lys Leu Glu Tyr Ser Tyr Cys Ser Pro Arg Lys Asn 
    130                 135                 140                 


Trp Gln Cys Ser Tyr Asp 
145                 150 


<210>  94
<211>  600
<212>  DNA
<213>  Dirofilaria immitis

<400>  94
atgactcttg ctggaagcaa agcattcatt ggtcaaccgg cccctaattt caaaacaaca       60

gcggttgtga atggcgattt caaggaaatt tcactttgtc agttcaaagg aaaatatgtg      120

gtcctcttct tttatcctct cgatttcact ttcgtttgcc caacagagat aattgctttt      180

tctgatcgta ttgcggagtt caaaaaatta gatgtagctg ttatggcatg ctcaactgat      240

tcacattttt cacaccttgc atggataaat actgaccgaa aaatgggtgg cctcggtcag      300

atgaatatac caattcttgc tgataccaat catacaatta gtagggcata tggcgtgctc      360

aaggaagatg atggcattgc ttaccgtgga ttattcatca ttgatccaaa agggattttg      420

cgacaaatca caatcaatga tcttccagtt ggtcgttctg tagatgaaac tttacgtctg      480

attcaagctt ttcaatttgt cgacaatcac ggtgaagtat gtccggccaa ttggcagcca      540

ggatctgaag caatcaaacc tggagtgaaa gaaagcaaag cgtacttcga aaagcactga      600


<210>  95
<211>  199
<212>  PRT
<213>  Dirofilaria immitis

<400>  95

Met Thr Leu Ala Gly Ser Lys Ala Phe Ile Gly Gln Pro Ala Pro Asn 
1               5                   10                  15      


Phe Lys Thr Thr Ala Val Val Asn Gly Asp Phe Lys Glu Ile Ser Leu 
            20                  25                  30          


Cys Gln Phe Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp 
        35                  40                  45              


Phe Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Leu 
    50                  55                  60                  


Ala Glu Phe Lys Lys Leu Asp Val Ala Val Met Ala Cys Ser Thr Asp 
65                  70                  75                  80  


Ser His Phe Ser His Leu Ala Trp Ile Asn Thr Asp Arg Lys Met Gly 
                85                  90                  95      


Gly Leu Gly Gln Met Asn Ile Pro Ile Leu Ala Asp Thr Asn His Thr 
            100                 105                 110         


Ile Ser Arg Ala Tyr Gly Val Leu Lys Glu Asp Asp Gly Ile Ala Tyr 
        115                 120                 125             


Arg Gly Leu Phe Ile Ile Asp Pro Lys Gly Ile Leu Arg Gln Ile Thr 
    130                 135                 140                 


Ile Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu 
145                 150                 155                 160 


Ile Gln Ala Phe Gln Phe Val Asp Asn His Gly Glu Val Cys Pro Ala 
                165                 170                 175     


Asn Trp Gln Pro Gly Ser Glu Ala Ile Lys Pro Gly Val Lys Glu Ser 
            180                 185                 190         


Lys Ala Tyr Phe Glu Lys His 
        195                 


<210>  96
<211>  1389
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  96
atggaagaga aagtagtgga actaacgcat aattggagtg ccgatcagtg ggattggcct       60

ttacagcata atgatgatgt ggttaaagtg accaatacga atgataagtt tgaagtaggt      120

ttggacgcat cattctttac gccgaaggaa atcgaggtga aggtttgtgg cgataatttg      180

gttattcact gtagacatga aacacgcact gatcaatatg gtgaaattaa acgtgaaatt      240

agtcgcactt ataaactccc atcggatgta gatacaaaga cattaacatc aaatttgact      300

aaacgaggac atctggttat tgctgccaaa aagaaggcat aaaacaaact tttcatagtt      360

cttggcttag cgcttctttt tgttgcatta ccttccgcat cagaatcaca agaagagact      420

gtatcttttg aagaaagcga cgaagattat gaagacgata gtgaagatca aacaaaagaa      480

gaggaacatt caaaagagga agatcattca gaagaacacg acgatcattc agctgaagac      540

gataaatttg taactaaagg aaaatttgtt gaaagtgacg gcaagatgaa gcattgcaaa      600

acccatgaag cttgctatga tcaacgtgaa ccacaatcgt ggtgcatatt aaaaccgcat      660

cagtcatgga cacaaagagg ttgtttctgc gaatcaaaaa aacatgcatg cgttatcgaa      720

cgaaaaagtg gcgacaaatt ggaatattcg tattgctcac cccgaaaaaa ctggcagtgt      780

tcatacgatt aaactcttgc tggaagcaaa gcattcattg gtcaaccggc ccctaatttc      840

aaaacaacag cggttgtgaa tggcgatttc aaggaaattt cactttgtca gttcaaagga      900

aaatatgtgg tcctcttctt ttatcctctc gatttcactt tcgtttgccc aacagagata      960

attgcttttt ctgatcgtat tgcggagttc aaaaaattag atgtagctgt tatggcatgc     1020

tcaactgatt cacatttttc acaccttgca tggataaata ctgaccgaaa aatgggtggc     1080

ctcggtcaga tgaatatacc aattcttgct gataccaatc atacaattag tagggcatat     1140

ggcgtgctca aggaagatga tggcattgct taccgtggat tattcatcat tgatccaaaa     1200

gggattttgc gacaaatcac aatcaatgat cttccagttg gtcgttctgt agatgaaact     1260

ttacgtctga ttcaagcttt tcaatttgtc gacaatcacg gtgaagtatg tccggccaat     1320

tggcagccag gatctgaagc aatcaaacct ggagtgaaag aaagcaaagc gtacttcgaa     1380

aagcactga                                                             1389


<210>  97
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Met Glu Glu Lys Val Val Glu Leu Thr His Asn Trp Ser Ala Asp Gln 
1               5                   10                  15      


Trp Asp Trp Pro Leu Gln His Asn Asp Asp Val Val Lys Val Thr Asn 
            20                  25                  30          


Thr Asn Asp Lys Phe Glu Val Gly Leu Asp Ala Ser Phe Phe Thr Pro 
        35                  40                  45              


Lys Glu Ile Glu Val Lys Val Cys Gly Asp Asn Leu Val Ile His Cys 
    50                  55                  60                  


Arg His Glu Thr Arg Thr Asp Gln Tyr Gly Glu Ile Lys Arg Glu Ile 
65                  70                  75                  80  


Ser Arg Thr Tyr Lys Leu Pro Ser Asp Val Asp Thr Lys Thr Leu Thr 
                85                  90                  95      


Ser Asn Leu Thr Lys Arg Gly His Leu Val Leu Ala Ala Lys Lys Lys 
            100                 105                 110         


Ala Met Asn Lys Leu Phe Ile Val Leu Gly Leu Ala Leu Leu Phe Val 
        115                 120                 125             


Ala Leu Pro Ser Ala Ser Glu Ser Gln Glu Glu Thr Val Ser Phe Glu 
    130                 135                 140                 


Glu Ser Asp Glu Asp Tyr Glu Asp Asp Ser Glu Asp Gln Thr Lys Glu 
145                 150                 155                 160 


Glu Glu His Ser Lys Glu Glu Asp His Ser Glu Glu His Asp Asp His 
                165                 170                 175     


Ser Ala Glu Asp Asp Lys Phe Val Thr Lys Gly Lys Phe Val Glu Ser 
            180                 185                 190         


Asp Gly Lys Met Lys His Cys Lys Thr His Glu Ala Cys Tyr Asp Gln 
        195                 200                 205             


Arg Glu Pro Gln Ser Trp Cys Ile Leu Lys Pro His Gln Ser Trp Thr 
    210                 215                 220                 


Gln Arg Gly Cys Phe Cys Glu Ser Lys Lys His Ala Cys Val Ile Glu 
225                 230                 235                 240 


Arg Lys Ser Gly Asp Lys Leu Glu Tyr Ser Tyr Cys Ser Pro Arg Lys 
                245                 250                 255     


Asn Trp Gln Cys Ser Tyr Asp Met Thr Leu Ala Gly Ser Lys Ala Phe 
            260                 265                 270         


Ile Gly Gln Pro Ala Pro Asn Phe Lys Thr Thr Ala Val Val Asn Gly 
        275                 280                 285             


Asp Phe Lys Glu Ile Ser Leu Cys Gln Phe Lys Gly Lys Tyr Val Val 
    290                 295                 300                 


Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
305                 310                 315                 320 


Ile Ala Phe Ser Asp Arg Ile Ala Glu Phe Lys Lys Leu Asp Val Ala 
                325                 330                 335     


Val Met Ala Cys Ser Thr Asp Ser His Phe Ser His Leu Ala Trp Ile 
            340                 345                 350         


Asn Thr Asp Arg Lys Met Gly Gly Leu Gly Gln Met Asn Ile Pro Ile 
        355                 360                 365             


Leu Ala Asp Thr Asn His Thr Ile Ser Arg Ala Tyr Gly Val Leu Lys 
    370                 375                 380                 


Glu Asp Asp Gly Ile Ala Tyr Arg Gly Leu Phe Ile Ile Asp Pro Lys 
385                 390                 395                 400 


Gly Ile Leu Arg Gln Ile Thr Ile Asn Asp Leu Pro Val Gly Arg Ser 
                405                 410                 415     


Val Asp Glu Thr Leu Arg Leu Ile Gln Ala Phe Gln Phe Val Asp Asn 
            420                 425                 430         


His Gly Glu Val Cys Pro Ala Asn Trp Gln Pro Gly Ser Glu Ala Ile 
        435                 440                 445             


Lys Pro Gly Val Lys Glu Ser Lys Ala Tyr Phe Glu Lys His 
    450                 455                 460         


<210>  98
<211>  23
<212>  PRT
<213>  Dirofilaria immitis

<400>  98

Ala Ser Glu Ser Gln Glu Glu Thr Val Ser Phe Glu Glu Ser Asp Glu 
1               5                   10                  15      


Asp Tyr Glu Asp Asp Ser Glu 
            20              


<210>  99
<211>  24
<212>  PRT
<213>  Dirofilaria immitis

<400>  99

Phe Val Glu Ser Asp Gly Lys Met Lys His Cys Lys Thr His Glu Ala 
1               5                   10                  15      


Cys Tyr Asp Gln Arg Glu Pro Gln 
            20                  


<210>  100
<211>  26
<212>  PRT
<213>  Dirofilaria immitis

<400>  100

Asn Trp Ser Ala Asp Gln Trp Asp Trp Pro Leu Gln His Asn Asp Asp 
1               5                   10                  15      


Val Val Lys Val Thr Asn Thr Asn Asp Lys 
            20                  25      


<210>  101
<211>  24
<212>  PRT
<213>  Dirofilaria immitis

<400>  101

Gly Glu Val Cys Pro Ala Asn Trp Gln Pro Gly Ser Glu Ala Ile Lys 
1               5                   10                  15      


Pro Gly Val Lys Glu Ser Lys Ala 
            20                  


<210>  102
<211>  627
<212>  DNA
<213>  Dirofilaria immitis

<400>  102
atgagttata agctgacata tttccctatc cgaggcttgg ctgagccaat ccgcttactt       60

ctcgttgatc aaggcataaa gtttactgac gaacacattc ctaaggatga tttcgtttcc      120

ataaaatcac aatttcaatt tgggcaattg ccttgtttct acgatggcga tcagcaaatt      180

gttcaatccg gtgccattct gagacatctt gcccgcaaat tcaatttgaa tggtgaaaat      240

aatgcggaaa caacatatgt cgacatgttc tatgagggca ttcgtgacct acacagcaaa      300

tacacaagaa tgatctatga ggcttatgaa actcaaaagg atccttttat aaaaaatata      360

ttgccacaag aattggcgaa acttgaaaaa ttgctggcta ctcgagacaa tggaaaaaat      420

ttcattctcg gagacaagat ttcattcgca gattacgtcc tttttgaaga gcttgacgtt      480

cagcaaatct tagatccaca ctgcttggag aaatttccat tgttgaaggc gtttcatcaa      540

cgattgggag ataaaccaaa aattaaggaa tattgcgcga agcgcaatgc atcaaagatg      600

ccagtgaatg gaaatgggaa gcagtaa                                          627


<210>  103
<211>  208
<212>  PRT
<213>  Dirofilaria immitis

<400>  103

Met Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly Leu Ala Glu Pro 
1               5                   10                  15      


Ile Arg Leu Leu Leu Val Asp Gln Gly Ile Lys Phe Thr Asp Glu His 
            20                  25                  30          


Ile Pro Lys Asp Asp Phe Val Ser Ile Lys Ser Gln Phe Gln Phe Gly 
        35                  40                  45              


Gln Leu Pro Cys Phe Tyr Asp Gly Asp Gln Gln Ile Val Gln Ser Gly 
    50                  55                  60                  


Ala Ile Leu Arg His Leu Ala Arg Lys Phe Asn Leu Asn Gly Glu Asn 
65                  70                  75                  80  


Asn Ala Glu Thr Thr Tyr Val Asp Met Phe Tyr Glu Gly Ile Arg Asp 
                85                  90                  95      


Leu His Ser Lys Tyr Thr Arg Met Ile Tyr Glu Ala Tyr Glu Thr Gln 
            100                 105                 110         


Lys Asp Pro Phe Ile Lys Asn Ile Leu Pro Gln Glu Leu Ala Lys Leu 
        115                 120                 125             


Glu Lys Leu Leu Ala Thr Arg Asp Asn Gly Lys Asn Phe Ile Leu Gly 
    130                 135                 140                 


Asp Lys Ile Ser Phe Ala Asp Tyr Val Leu Phe Glu Glu Leu Asp Val 
145                 150                 155                 160 


Gln Gln Ile Leu Asp Pro His Cys Leu Glu Lys Phe Pro Leu Leu Lys 
                165                 170                 175     


Ala Phe His Gln Arg Leu Gly Asp Lys Pro Lys Ile Lys Glu Tyr Cys 
            180                 185                 190         


Ala Lys Arg Asn Ala Ser Lys Met Pro Val Asn Gly Asn Gly Lys Gln 
        195                 200                 205             


<210>  104
<211>  71
<212>  PRT
<213>  Brugia malayi


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Asp Asn Ala Leu Asp Arg Ala Asp Ala Ala Xaa Glu Lys Val Arg Gln 
1               5                   10                  15      


Met Thr Asp Lys Leu Glu Arg Ile Glu Glu Glu Leu Arg Asp Thr Gln 
            20                  25                  30          


Lys Lys Met Met Gln Thr Glu Asn Asp Leu Asp Lys Ala Gln Glu Asp 
        35                  40                  45              


Leu Ala Val Ala Asn Thr Asn Leu Glu Glu Lys Glu Lys Lys Val Gln 
    50                  55                  60                  


Glu Val Lys Phe Lys Lys Phe 
65                  70      


<210>  105
<211>  71
<212>  PRT
<213>  Dirofilaria sp.

<400>  105

Met Ile Thr Met Thr Val Asp Asn Ala Leu Asp Arg Ala Asp Ala Ala 
1               5                   10                  15      


Glu Glu Lys Val Arg Gln Met Thr Asp Lys Leu Glu Arg Ile Glu Glu 
            20                  25                  30          


Glu Leu Arg Asp Thr Gln Lys Lys Met Met Gln Thr Glu Asn Asp Leu 
        35                  40                  45              


Asp Lys Ala Gln Glu Asp Leu Ala Val Ala Asn Thr Asn Leu Glu Glu 
    50                  55                  60                  


Lys Glu Lys Lys Val Gln Glu 
65                  70      


<210>  106
<211>  504
<212>  PRT
<213>  Brugia malayi

<400>  106

Met Asn Arg Thr Thr Leu Ile Leu Phe Phe Ile Ile Leu Ser Asn Thr 
1               5                   10                  15      


Ile Thr Val Ile His Gly Tyr Val Arg Gly Cys Tyr Tyr Thr Asn Trp 
            20                  25                  30          


Ala Gln Tyr Arg Asp Gly Glu Gly Lys Phe Leu Pro Gly Asn Ile Pro 
        35                  40                  45              


Asn Gly Leu Cys Thr His Ile Leu Tyr Ala Phe Ala Lys Val Asp Glu 
    50                  55                  60                  


Leu Gly Asp Ser Lys Pro Phe Glu Trp Asn Asp Glu Asp Thr Glu Trp 
65                  70                  75                  80  


Ser Lys Gly Met Tyr Ser Ala Val Thr Lys Leu Arg Glu Thr Asn Pro 
                85                  90                  95      


Gly Leu Lys Val Leu Leu Ser Tyr Gly Gly Tyr Asn Phe Gly Ser Ala 
            100                 105                 110         


Ile Phe Thr Gly Ile Ala Lys Ser Ala Gln Lys Thr Glu Arg Phe Ile 
        115                 120                 125             


Lys Ser Ala Ile Ala Phe Leu Arg Lys Asn Asn Phe Asp Gly Phe Asp 
    130                 135                 140                 


Leu Asp Trp Glu Tyr Pro Val Gly Val Ala Glu Glu His Ala Lys Leu 
145                 150                 155                 160 


Val Glu Ala Met Lys Thr Ala Phe Val Glu Glu Ala Lys Thr Ser Gly 
                165                 170                 175     


Lys Gln Arg Leu Leu Leu Thr Ala Ala Val Ser Ala Gly Lys Gly Thr 
            180                 185                 190         


Ile Asp Gly Ser Tyr Asn Val Glu Ser Leu Gly Lys Asn Phe Asp Leu 
        195                 200                 205             


Leu Phe Leu Met Ser Tyr Asp Leu His Gly Ser Trp Glu Lys Asn Val 
    210                 215                 220                 


Asp Leu His Gly Lys Leu His Pro Thr Lys Gly Glu Val Ser Gly Ile 
225                 230                 235                 240 


Gly Ile Phe Asn Thr Glu Phe Ala Ala Asp Tyr Trp Ala Ser Lys Gly 
                245                 250                 255     


Met Pro Lys Glu Lys Ile Ile Ile Gly Ile Pro Met Tyr Ala Gln Gly 
            260                 265                 270         


Trp Thr Leu Asp Asn Pro Ser Glu Thr Ala Ile Gly Ala Ala Ala Ser 
        275                 280                 285             


Arg Pro Ser Ser Ala Ser Lys Thr Asn Pro Ala Gly Gly Thr Ala Ser 
    290                 295                 300                 


Tyr Trp Glu Ile Cys Lys Tyr Leu Lys Glu Gly Gly Lys Glu Thr Val 
305                 310                 315                 320 


His Gln Glu Gly Val Gly Ala Tyr Met Val Lys Gly Asp Gln Trp Tyr 
                325                 330                 335     


Gly Tyr Asp Asn Glu Glu Thr Ile Arg Ile Lys Met Lys Trp Leu Lys 
            340                 345                 350         


Glu Lys Gly Tyr Gly Gly Ala Phe Ile Trp Ala Leu Asp Phe Asp Asp 
        355                 360                 365             


Phe Thr Gly Lys Ser Cys Gly Lys Gly Pro Tyr Pro Leu Leu Asn Ala 
    370                 375                 380                 


Ile Ser Ser Glu Leu Glu Gly Glu Ser Glu Asn Pro Glu Ile Thr Thr 
385                 390                 395                 400 


Glu Glu Pro Ser Ile Thr Glu Thr Glu Ala Tyr Glu Thr Asp Glu Thr 
                405                 410                 415     


Glu Glu Thr Ser Glu Thr Glu Ala Tyr Asp Thr Asp Glu Thr Glu Glu 
            420                 425                 430         


Thr Ser Glu Thr Glu Ala Thr Thr Tyr Asp Thr Asp Glu Thr Glu Gly 
        435                 440                 445             


Gln Glu Cys Pro Glu Arg Asp Gly Leu Phe Pro His Pro Thr Asp Cys 
    450                 455                 460                 


His Leu Phe Ile Gln Cys Ala Asn Asn Ile Ala His Val Met Gln Cys 
465                 470                 475                 480 


Pro Ala Thr Thr Phe Phe Asn Asp Ala Ile Lys Val Cys Asp His Met 
                485                 490                 495     


Thr Asn Ala Pro Asp Thr Cys Ile 
            500                 


<210>  107
<211>  454
<212>  PRT
<213>  Dirofilaria sp.

<400>  107

Met Tyr Phe His Leu Glu Gly Asp Gly Lys Phe Leu Pro Glu Asn Leu 
1               5                   10                  15      


Pro Lys Gly Leu Cys Thr His Leu Leu Tyr Ala Phe Ala Lys Val Asp 
            20                  25                  30          


Gln Leu Gly Leu Ser Gln Ala Phe Glu Trp Asn Asp Glu Asp Thr Glu 
        35                  40                  45              


Trp Ser Lys Gly Met Tyr Ser Arg Val Leu Glu Leu Lys Asn Thr Asp 
    50                  55                  60                  


Pro Glu Leu Lys Leu Leu Leu Ser Tyr Gly Gly Tyr Asn Phe Gly Ser 
65                  70                  75                  80  


Ala Leu Phe Thr Ala Leu Ala Lys Ser Ala Glu Lys Arg Lys His Phe 
                85                  90                  95      


Ile Glu Ser Ala Leu Glu Phe Leu Arg Lys Asn Lys Phe Asp Gly Phe 
            100                 105                 110         


Asp Leu Asp Trp Glu Tyr Pro Leu Gly Ala Val Glu Glu His Ala Lys 
        115                 120                 125             


Leu Val Glu Glu Met Lys Ala Ala Phe Met Asn Glu Ala Lys Arg Ser 
    130                 135                 140                 


Gly Asn Gln Gln Leu Leu Leu Thr Ala Ala Val Ser Ala Gly Lys His 
145                 150                 155                 160 


Leu Leu Asp Gln Ser Tyr Lys Val Leu Ser Leu Ala Lys Asn Phe Asp 
                165                 170                 175     


Leu Leu Phe Leu Met Ser Tyr Asp Leu His Gly Ser Trp Glu Asn Lys 
            180                 185                 190         


Val Asp Leu His Ala Lys Leu Tyr Pro Thr Lys Gly Glu Thr Phe Gly 
        195                 200                 205             


Leu Gly Leu Phe Asn Thr Glu Phe Ala Ala Glu Tyr Trp Val Ser Lys 
    210                 215                 220                 


Gly Met Pro Lys Gln Lys Leu Leu Leu Gly Leu Pro Thr Tyr Gly Arg 
225                 230                 235                 240 


Gly Trp Thr Leu Lys Asn Pro Ser Glu Thr Met Leu Gly Ala Ala Ser 
                245                 250                 255     


Leu Gly Ala Ser Ala Ala Ser Thr Thr Asn Pro Ala Gly Gly Ser Ala 
            260                 265                 270         


Ala Tyr Trp Glu Leu Cys Lys Tyr Leu Lys Lys Gly Gly Lys Glu Thr 
        275                 280                 285             


Leu Asp Lys Gln Gly Leu Gly Ala Tyr Met Val Gln Glu Asn Gln Trp 
    290                 295                 300                 


Tyr Ser Tyr Asp Asn Glu Glu Thr Leu Lys Leu Lys Met Lys Trp Leu 
305                 310                 315                 320 


Lys Lys Lys Gly Tyr Gly Gly Ala Phe Leu Trp Ser Leu Asp Phe Asp 
                325                 330                 335     


Asp Phe Lys Gly Ala Ser Cys Gly Lys Gly Pro Tyr Pro Leu Leu Ser 
            340                 345                 350         


Ala Leu Asn Arg Glu Leu Gly Ser Lys Leu Ala Ala Ser Ala Lys Ser 
        355                 360                 365             


Leu Gln Ile Thr Pro Pro Pro Ser Glu Leu Ala Glu Asn Val Val Leu 
    370                 375                 380                 


Lys Met Thr Thr Ser Val Lys Pro Thr Glu Gln Phe Phe Asp Leu Lys 
385                 390                 395                 400 


Cys Pro Glu Ser Ser Gly Leu Phe Gln Tyr Pro Ser Asp Cys His Met 
                405                 410                 415     


Phe Leu Leu Cys Ala His Asp Tyr Ser Tyr Val Met Ala Cys Pro Pro 
            420                 425                 430         


Asn Thr Phe Phe Asn Asp Asn Ser Lys Val Cys Asp His Met Met Asn 
        435                 440                 445             


Ala Ala Gly Thr Cys Lys 
    450                 


<210>  108
<211>  125
<212>  PRT
<213>  Brugia malayi

<400>  108

Met Asn Lys Leu Leu Ile Ala Phe Gly Leu Ile Ile Leu Thr Val Thr 
1               5                   10                  15      


Leu Pro Cys Met Ser Gln Ser Asp Asp Glu Phe Asp Asp Glu Ser Ser 
            20                  25                  30          


Gly Ala Asp Glu Gly Gly Asp Gly Ser Glu Gly Gly Asp Glu Tyr Val 
        35                  40                  45              


Thr Lys Gly Glu Phe Val Glu Thr Asp Gly Lys Lys Lys Glu Cys Thr 
    50                  55                  60                  


Ser His Glu Ala Cys Tyr Asp Gln Arg Glu Pro Gln Ala Trp Cys Arg 
65                  70                  75                  80  


Leu Asp Glu Asn Gln Ser Trp Thr Asp Lys Gly Cys Phe Cys Asp Asp 
                85                  90                  95      


Lys Leu His Ser Cys Val Ile Glu Arg Lys Asn Ser Gly Lys Leu Glu 
            100                 105                 110         


Tyr Ser Tyr Cys Ala Pro Gln Glu Ser Trp Gln Cys Ser 
        115                 120                 125 


<210>  109
<211>  144
<212>  PRT
<213>  Dirofilaria sp.

<400>  109

Met Asn Lys Leu Phe Leu Phe Leu Gly Leu Val Leu Leu Phe Val Ser 
1               5                   10                  15      


Ser Phe Ser Ala Ser Glu Ser Glu Ser Glu Asp Val Thr Phe Glu Glu 
            20                  25                  30          


Ser Asp Glu Asp Tyr Glu Glu Asp Glu Asp Asn Ser Glu Asp Gln Asn 
        35                  40                  45              


Asn Gln Ser Asn Glu His Asp Asp His Pro Thr Glu Asp Asp Glu Tyr 
    50                  55                  60                  


Val Thr Lys Gly Glu Phe Val Glu Ser Asp Gly Lys Met Lys His Cys 
65                  70                  75                  80  


Glu Thr His Glu Ala Cys Tyr Asp Gln Arg Glu Pro Gln Ser Trp Cys 
                85                  90                  95      


Leu Leu Lys Pro His Gln Ser Trp Thr Gln Arg Gly Cys Phe Cys Glu 
            100                 105                 110         


Ser Lys Lys His Ala Cys Val Leu Glu Arg Lys Ser Gly Asp Lys Leu 
        115                 120                 125             


Glu Tyr Ser Tyr Cys Ser Pro Arg Asn Asn Trp Gln Cys Ser Tyr Asp 
    130                 135                 140                 


<210>  110
<211>  153
<212>  PRT
<213>  Brugia malayi

<400>  110

Met Lys Tyr Phe Ile Phe Leu Ser Ile Gly Leu Ile Ala Ala Ala Ser 
1               5                   10                  15      


Ala Gln Arg Glu Ala Gln Leu Pro Gln Pro Glu Ile Pro Pro Phe Leu 
            20                  25                  30          


Ser Gly Ala Pro Ser His Val Val Lys Gln Phe Phe Asp Leu Leu Lys 
        35                  40                  45              


Ala Asp Glu Ser Lys Thr Asp Pro Gln Thr Glu Ala Asp Ile Glu Ala 
    50                  55                  60                  


Phe Ile Arg Arg Leu Gly Gly Asp Tyr Gln Thr Arg Phe Glu Gln Phe 
65                  70                  75                  80  


Lys Gln Glu Ile Lys Lys Glu Lys Ala Gln Tyr Glu Lys Ile His Gln 
                85                  90                  95      


Ala Ala Leu Leu Lys Phe Ser Pro Ala Ala Arg Glu Ala Asp Ala Lys 
            100                 105                 110         


Met Ser Ala Ile Ala Asp Ser Thr Gln Leu Thr Asn His Gln Lys Thr 
        115                 120                 125             


Glu Gln Ile Lys Ala Ile Met Asp Ser Leu Ser Glu Ala Val Arg Lys 
    130                 135                 140                 


Glu Ile Leu Glu Gly Phe Asn Ser Gln 
145                 150             


<210>  111
<211>  116
<212>  PRT
<213>  Dirofilaria sp.

<400>  111

Met Ile Leu Glu Gln Leu Glu Val Pro Pro Phe Leu Val Gly Ala Pro 
1               5                   10                  15      


Gln Ser Val Ile Lys Gln Phe Tyr Asp Leu Leu Lys Ala Asp Glu Thr 
            20                  25                  30          


Lys Thr Asp Ala Gln Thr Glu Ala Asp Val Glu Ala Phe Ile Asn Arg 
        35                  40                  45              


Leu Gly Gly Thr Tyr Lys Thr Arg Phe Asp Gln Phe Lys Gln Glu Ile 
    50                  55                  60                  


Lys Gln Gly Lys Ala Ala Tyr Glu Arg Leu His Gln Gln Ala Val Ala 
65                  70                  75                  80  


Lys Phe Ser Lys Glu Ala Arg Glu Ala Asp Ala Lys Met Ser Ala Ile 
                85                  90                  95      


Ala Asp Ser Pro Ser Leu Thr Thr Gln Gln Lys Thr Gln Gln Ile Gln 
            100                 105                 110         


Ala Ile Met Asp 
        115     


<210>  112
<211>  220
<212>  PRT
<213>  Brugia malayi

<400>  112

Met Leu Phe Phe Val Ile Phe Ser Ile Thr Ile Ala Val Val Ala Gly 
1               5                   10                  15      


Phe Glu Cys Pro Gly Gly Arg Leu Thr Pro Gln Gln Arg Lys Asp Ile 
            20                  25                  30          


Val Arg Gln Asn Asn Lys Phe Arg Ser Leu Leu Ile His Gly Lys Leu 
        35                  40                  45              


Lys Asn Arg Asn Gly Thr Tyr Met Pro Arg Gly Lys Asn Met Leu Leu 
    50                  55                  60                  


Leu Lys Trp Ser Cys Gln Leu Glu Asn Ser Ala Gln Arg Trp Ala Asn 
65                  70                  75                  80  


Gln Cys Val Phe Gly His Ser Pro Arg Asn Gln Arg Gln Gly Ile Gly 
                85                  90                  95      


Glu Asn Val Tyr Ala Tyr Trp Ser Ser Glu Ser Val Glu Lys Leu Arg 
            100                 105                 110         


Asn Thr Ala Gly Thr Glu Ala Gly Lys Ser Trp Trp Ser Glu Leu Pro 
        115                 120                 125             


Lys Leu Tyr Lys Gln Asn Pro Ser Asn Asn Leu Thr Asp Asp Val Ala 
    130                 135                 140                 


Arg Gln Gly Val Leu His Phe Thr Gln Met Ala Trp Gly Lys Thr His 
145                 150                 155                 160 


Lys Ile Gly Cys Gly Ile Ala Thr Asn Cys Asp Gly Gly Arg Thr Leu 
                165                 170                 175     


Ile Ala Ile Cys His Tyr Ser Pro Ala Gly Asn Met Leu Lys Glu Leu 
            180                 185                 190         


Ile Tyr Glu Leu Gly Glu Pro Cys Lys Thr Asp Ser Asp Cys Asn Thr 
        195                 200                 205             


Lys Lys Cys Ala Lys Lys Ser Gly Leu Cys Arg Lys 
    210                 215                 220 


<210>  113
<211>  152
<212>  PRT
<213>  Dirofilaria immitis

<400>  113

Lys Leu Glu Lys Ser Ala Gln Asn Trp Ala Asn Met Cys Val Phe Gly 
1               5                   10                  15      


His Ser Pro Ser Ser Glu Arg Arg Gly Ile Gly Glu Asn Val Tyr Ala 
            20                  25                  30          


Tyr Trp Ser Ser Gly Ser Val Arg Asp Leu Lys Lys Thr Ala Gly Thr 
        35                  40                  45              


Asp Ala Gly Arg Leu Trp Trp Ser Glu Leu Glu Lys Tyr Val Ser Asp 
    50                  55                  60                  


Asn Pro Ser Asn Asn Leu Thr Ser Glu Val Ala Met Glu Asn Ile Leu 
65                  70                  75                  80  


His Phe Thr Gln Met Ala Trp Gly Glu Thr Tyr Lys Leu Gly Ser Gly 
                85                  90                  95      


Val Asp His Asn Ile Val Met Val Ala Arg Thr Leu Val Phe Ile Cys 
            100                 105                 110         


His Tyr Phe Pro Gly Gly Asn Met Val Lys Asp Leu Ile Tyr Glu Leu 
        115                 120                 125             


Gly Asn Pro Cys Lys His Asn Lys Asp Cys Arg Thr Lys Arg Cys Ser 
    130                 135                 140                 


Ala Lys Ser Gly Leu Cys Lys Lys 
145                 150         


<210>  114
<211>  115
<212>  PRT
<213>  Brugia malayi

<400>  114

Met Pro Tyr Phe Thr Ile Asp Thr Asn Ile Pro Gln Asn Ser Ile Ser 
1               5                   10                  15      


Ser Ala Phe Leu Lys Lys Ala Ser Asn Val Val Ala Lys Ala Leu Gly 
            20                  25                  30          


Lys Pro Glu Ser Tyr Val Ser Ile His Val Asn Gly Gly Gln Ala Met 
        35                  40                  45              


Val Phe Gly Gly Ser Glu Asp Pro Cys Ala Val Cys Val Leu Lys Ser 
    50                  55                  60                  


Ile Gly Cys Val Gly Pro Lys Val Asn Asn Ser His Ala Glu Lys Leu 
65                  70                  75                  80  


Tyr Lys Leu Leu Ala Asp Glu Leu Lys Ile Pro Lys Asn Arg Cys Tyr 
                85                  90                  95      


Ile Glu Phe Val Asp Ile Glu Ala Ser Ser Met Ala Phe Asn Gly Ser 
            100                 105                 110         


Thr Phe Gly 
        115 


<210>  115
<211>  115
<212>  PRT
<213>  Dirofilaria immitis

<400>  115

Met Pro Tyr Phe Thr Ile Asp Thr Asn Ile Pro Gln Asp Arg Val Ser 
1               5                   10                  15      


Asp Ala Phe Leu Lys Lys Ala Ser Ser Thr Val Ala Lys Ala Leu Gly 
            20                  25                  30          


Lys Pro Glu Ser Tyr Val Ser Ile His Val Asn Gly Gly Gln Ala Met 
        35                  40                  45              


Thr Phe Gly Gly Ser Thr Asp Pro Cys Ala Val Cys Val Leu Lys Ser 
    50                  55                  60                  


Ile Gly Ser Val Gly Pro Ser Val Asn Asn Ser His Cys Glu Lys Leu 
65                  70                  75                  80  


Tyr Lys Leu Leu Ala Asp Glu Leu Lys Ile Pro Lys Asn Arg Cys Tyr 
                85                  90                  95      


Ile Glu Phe Val Asp Ile Asn Ala Ser Ala Met Gly Phe Asn Gly Ser 
            100                 105                 110         


Thr Phe Gly 
        115 


<210>  116
<211>  120
<212>  PRT
<213>  Brugia malayi

<400>  116

Met Pro Leu Ile Thr Leu Ala Ser Asn Val Pro Ala Ser Arg Phe Pro 
1               5                   10                  15      


Ser Asp Phe Asn Val Gln Phe Thr Glu Leu Met Ala Lys Met Leu Gly 
            20                  25                  30          


Lys Pro Thr Ser Arg Ile Leu Leu Leu Val Met Pro Asn Ala Gln Leu 
        35                  40                  45              


Ser His Gly Thr Thr Glu Asn Pro Ser Cys Phe Thr Val Val Lys Ser 
    50                  55                  60                  


Ile Gly Ser Phe Ser Ala Asp Lys Asn Ile Glu Tyr Ser Ser Leu Ile 
65                  70                  75                  80  


Ser Glu Phe Met Lys Lys Thr Leu Asp Ile Asp Pro Ala His Cys Ile 
                85                  90                  95      


Ile His Phe Leu Asn Leu Asp Pro Glu Asn Val Gly Cys Asn Gly Thr 
            100                 105                 110         


Thr Met Lys Glu Leu Met Lys Lys 
        115                 120 


<210>  117
<211>  78
<212>  PRT
<213>  Dirofilaria sp.

<400>  117

Met Phe Ala Leu Ile Asp Val Ala Arg Tyr Glu Thr Ile Lys Tyr Pro 
1               5                   10                  15      


Thr Pro Leu Ile Lys Ser Ile Gly Ser Phe Ser Ala Asp Lys Asn Ile 
            20                  25                  30          


Lys Tyr Ser Ala Ser Ile Ser Glu Phe Ile Lys Lys Thr Leu Gly Ile 
        35                  40                  45              


Asp Pro Ala His Cys Leu Ile His Phe Phe Asn Leu Asp Pro Glu Asp 
    50                  55                  60                  


Val Gly Cys Asn Gly Thr Thr Met Lys Glu Leu Met Lys Lys 
65                  70                  75              


<210>  118
<211>  161
<212>  PRT
<213>  Brugia malayi

<400>  118

Met Met Ser Thr Met Ser Ile Lys Glu Gly Leu Leu Val Ile Leu Leu 
1               5                   10                  15      


Ser Leu Phe Leu Phe Asp Thr Thr Ala Leu Ile His Arg Arg Glu Ile 
            20                  25                  30          


Pro His Met Glu Ser Lys Gly Gln Met Gln Arg Gly Gln Val Leu Leu 
        35                  40                  45              


Gly Gly Trp Gln Glu Arg Ser Pro Glu Asp Asn Glu Ile Leu Glu Leu 
    50                  55                  60                  


Leu Pro Ser Val Leu Thr Lys Val Asn Gln Gln Ser Asn Asp Glu Tyr 
65                  70                  75                  80  


His Leu Met Pro Ile Lys Leu Leu Lys Val Ser Ser Gln Val Val Ala 
                85                  90                  95      


Gly Val Lys Tyr Lys Met Glu Val Gln Val Ala Arg Ser Glu Cys Lys 
            100                 105                 110         


Lys Ser Ala Ser Glu Gln Val Asn Leu Lys Thr Cys Lys Lys Leu Glu 
        115                 120                 125             


Gly His Pro Asp Gln Val Met Thr Leu Glu Val Trp Glu Lys Pro Trp 
    130                 135                 140                 


Glu Asp Phe Leu Gln Val Asn Ile Leu Glu Thr Lys Val Leu Ser Ser 
145                 150                 155                 160 


Val 
    


<210>  119
<211>  162
<212>  PRT
<213>  Dirofilaria sp.

<400>  119

Met Thr Met Leu Val Ser Ile Lys Asp Gly Ser Tyr Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Phe Ser Leu Ile Thr Leu Val Gln Leu Arg Glu Ala Lys Glu 
            20                  25                  30          


Ala Lys Val Thr Gly Ile Met Glu Ser Lys Thr Asn Glu Arg Pro His 
        35                  40                  45              


Glu Val Leu Leu Gly Gly Trp Glu Glu Arg Asp Pro Gln Asp Glu Glu 
    50                  55                  60                  


Ile Leu Glu Leu Leu Pro Ser Ile Leu Thr Lys Val Asn Glu Gln Ser 
65                  70                  75                  80  


Asn Asp Glu Tyr Tyr Leu Val Pro Ile Lys Leu Leu Lys Val Ser Ser 
                85                  90                  95      


Gln Val Val Ala Gly Val Lys Tyr Lys Met Asp Val Gln Val Ala Arg 
            100                 105                 110         


Ser Glu Cys Lys Lys Ser Ser Asn Glu Lys Val Asp Leu Lys Thr Cys 
        115                 120                 125             


Lys Lys Leu Gly His Pro Asp Gln Val Met Thr Leu Glu Ile Trp Glu 
    130                 135                 140                 


Lys Pro Trp Glu Asn Phe Leu Arg Val Asn Ile Leu Glu Thr Lys Val 
145                 150                 155                 160 


Leu Pro 
        


<210>  120
<211>  208
<212>  PRT
<213>  Brugia malayi

<400>  120

Met Ser Tyr Lys Leu Thr Tyr Phe Pro Ile Arg Gly Leu Ala Glu Pro 
1               5                   10                  15      


Ile Arg Leu Val Leu Val Asp Gln Gly Ile Lys Phe Thr Asp Asp Arg 
            20                  25                  30          


Ile Asn Ala Ser Asp Trp Pro Ser Met Lys Ser His Phe His Phe Gly 
        35                  40                  45              


Gln Leu Pro Cys Leu Tyr Asp Gly Asp His Gln Ile Val Gln Ser Gly 
    50                  55                  60                  


Ala Ile Leu Arg His Leu Ala Arg Lys His Asn Leu Asn Gly Gly Asn 
65                  70                  75                  80  


Glu Leu Glu Thr Thr His Ile Asp Met Phe Cys Glu Gly Val Arg Asp 
                85                  90                  95      


Leu His Thr Lys Tyr Thr Lys Met Ile Tyr Gln Ala Tyr Asp Thr Glu 
            100                 105                 110         


Lys Asp Ser Tyr Ile Lys Asp Ile Leu Pro Val Glu Leu Ala Lys Phe 
        115                 120                 125             


Glu Lys Leu Leu Ala Thr Arg Asp Asp Gly Lys Asn Phe Ile Leu Gly 
    130                 135                 140                 


Glu Lys Ile Ser Tyr Val Asp Phe Val Leu Phe Glu Glu Leu Asp Ile 
145                 150                 155                 160 


His Gln Ile Leu Asp Pro His Cys Leu Asp Lys Phe Pro Leu Leu Lys 
                165                 170                 175     


Ala Tyr His Gln Arg Met Glu Asp Arg Pro Gly Leu Lys Glu Tyr Cys 
            180                 185                 190         


Lys Gln Arg Asn Arg Ala Lys Ile Pro Val Asn Gly Asn Gly Lys Gln 
        195                 200                 205             


<210>  121
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa denotes Val or Phe

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa denotes Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa denotes Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa denotes Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa denotes Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa denotes Asp or Ser

<400>  121

Xaa Xaa Glu Ser Asp Glu Xaa Xaa Xaa Asp Xaa 
1               5                   10      


<210>  122
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Met or Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or His

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ser or Lys

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Ser or Thr

<400>  122

Phe Val Glu Xaa Asp Gly Lys Xaa Lys Xaa Cys Xaa Xaa His Glu Ala 
1               5                   10                  15      


Cys Tyr Asp Gln Arg Glu Pro Gln 
            20                  


<210>  123
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Glu or Asp

<400>  123

Trp Ser Ala Xaa Gln Trp Asp Trp Pro Leu Gln His 
1               5                   10          


<210>  124
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is His or Gln

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Thr or Ala

<400>  124

Gly Glu Val Cys Pro Ala Asn Trp Xaa Pro Gly Ser Glu Xaa Ile Lys 
1               5                   10                  15      


Pro Gly Val Lys Glu Ser Lys Ala 
            20                  


