                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HLA CLASS I-RESTRICTED T CELL RECEPTORS AGAINST RAS WITH G12D 
       MUTATION

<130>  751506

<150>  US 62/975,544
<151>  2020-02-12

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Thr Ala Phe Asp Tyr 
1               5       


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Arg Pro Asp Val Ser Glu 
1               5           


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu Gly Arg Leu Tyr 
1               5                   10                  15      


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gly His Arg Ser 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Phe Ser Glu Thr Gln 
1               5       


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe 
1               5                   10                  


<210>  7
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro 
145 


<210>  8
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ala Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  9
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  10
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  11
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  12
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  13
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  14
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  15
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  17
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  17

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa 
            100                 105                 110         


Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  18
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa is Ser or Cys

<400>  18

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  19
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  19

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser 
            100                 105                 110         


Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  20
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  21
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (257)..(257)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (259)..(259)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  21

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  22
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  Xaa is Ser or Cys

<400>  22

Met Ala Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  23
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  24
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ala Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  26
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile 
            20                  


<210>  27
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile 
            20                  


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  32
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Gln Gln Val Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly 
1               5                   10                  15      


Gly Ile Ser Ile Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile 
        35                  40                  45              


Ala Ile Arg Pro Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Phe Asn Lys Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn 
                85                  90                  95      


His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln 
            100                 105                 110         


Leu Thr Val Trp Pro 
        115         


<210>  33
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  33

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala 
                85                  90                  95      


Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  34
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (229)..(229)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (232)..(232)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  34

Gln Gln Gln Val Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly 
1               5                   10                  15      


Gly Ile Ser Ile Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile 
        35                  40                  45              


Ala Ile Arg Pro Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Phe Asn Lys Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn 
                85                  90                  95      


His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln 
            100                 105                 110         


Leu Thr Val Trp Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
145                 150                 155                 160 


Ile Thr Asp Lys Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
                165                 170                 175     


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
            180                 185                 190         


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
        195                 200                 205             


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
    210                 215                 220                 


Phe Gln Asn Leu Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val 
225                 230                 235                 240 


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250                 


<210>  35
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Xaa is Ser or Cys

<400>  35

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala 
                85                  90                  95      


Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  36
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Gln Gln Gln Val Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly 
1               5                   10                  15      


Gly Ile Ser Ile Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile 
        35                  40                  45              


Ala Ile Arg Pro Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Phe Asn Lys Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn 
                85                  90                  95      


His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln 
            100                 105                 110         


Leu Thr Val Trp Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
145                 150                 155                 160 


Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
                165                 170                 175     


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
            180                 185                 190         


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
        195                 200                 205             


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
    210                 215                 220                 


Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
225                 230                 235                 240 


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250                 


<210>  37
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala 
                85                  90                  95      


Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  38
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  39
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  40
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Asp Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  41
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Ala Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  42
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Gln Gln Gln Val Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly 
1               5                   10                  15      


Gly Ile Ser Ile Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr 
            20                  25                  30          


Phe Pro Trp Tyr Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile 
        35                  40                  45              


Ala Ile Arg Pro Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Phe Asn Lys Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn 
                85                  90                  95      


His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln 
            100                 105                 110         


Leu Thr Val Trp Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
145                 150                 155                 160 


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
                165                 170                 175     


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
            180                 185                 190         


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
        195                 200                 205             


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
    210                 215                 220                 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
225                 230                 235                 240 


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250                 


<210>  43
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala 
                85                  90                  95      


Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  44
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  44
atggacaaga tcctgggcgc ctcttttctg gtgctgtggc tgcagctgtg ctgggtgtcc       60

ggacagcaga aggagaagtc tgatcagcag caggtgaagc agtctcccca gagcctgatc      120

gtgcagaagg gcggcatcag catcatcaac tgtgcctacg agaataccgc cttcgattac      180

tttccctggt atcagcagtt cccaggcaag ggacccgccc tgctgatcgc aatcaggcct      240

gacgtgagcg agaagaagga gggccgcttc acaatcagct ttaataagtc cgccaagcag      300

ttctccctgc acatcatgga cagccagccc ggcgattccg ccacctactt ttgtgcagca      360

gaggcaggaa accacagggg ctccacactg ggccggctgt atttcggcag aggcacccag      420

ctgacagtgt ggcct                                                       435


<210>  45
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  45
atggcctcca ggctgctgtg ctgggtgctg ctgtgcctgc tgggagcagg accagtgaag       60

gcaggcgtga cccagacacc taggtacctg atcaagaccc gcggccagca ggtgacactg      120

tcttgcagcc caatcagcgg ccaccgctcc gtgtcttggt accagcagac cccaggacag      180

ggcctgcagt tcctgtttga gtatttctcc gagacacaga ggaacaaggg caatttccct      240

ggccggtttt ctggcagaca gtttagcaac tcccgctctg agatgaacgt gagcaccctg      300

gagctgggcg atagcgccct gtacctgtgc gccagctccc tggccgcagg aggctatttc      360

aacgagcagt tctttggacc aggaaccagg ctgacagtgc tg                         402


<210>  46
<211>  1859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
ccatggcctc caggctgctg tgctgggtgc tgctgtgcct gctgggagca ggaccagtga       60

aggcaggcgt gacccagaca cctaggtacc tgatcaagac ccgcggccag caggtgacac      120

tgtcttgcag cccaatcagc ggccaccgct ccgtgtcttg gtaccagcag accccaggac      180

agggcctgca gttcctgttt gagtatttct ccgagacaca gaggaacaag ggcaatttcc      240

ctggccggtt ttctggcaga cagtttagca actcccgctc tgagatgaac gtgagcaccc      300

tggagctggg cgatagcgcc ctgtacctgt gcgccagctc cctggccgca ggaggctatt      360

tcaacgagca gttctttgga ccaggaacca ggctgacagt gctggaggac ctgagaaatg      420

tgaccccccc taaggtgtcc ctgtttgagc cttctaaggc cgagatcgcc aacaagcaga      480

aggccaccct ggtgtgcctg gcaaggggct tctttccaga tcacgtggag ctgagctggt      540

gggtgaatgg caaggaggtg cactccggcg tgtgcaccga cccacaggcc tacaaggaga      600

gcaactactc ctattgtctg tctagccggc tgagagtgtc cgccacattc tggcacaacc      660

caaggaatca cttccgctgc caggtgcagt ttcacggcct gagcgaggag gataagtggc      720

cagagggctc cccaaagcca gtgacccaga atatctctgc cgaggcatgg ggaagggcag      780

actgtggaat caccagcgcc tcctatcagc agggcgtgct gagcgccaca atcctgtacg      840

agatcctgct gggcaaggcc accctgtatg ccgtgctggt gtccacactg gtggtcatgg      900

ctatggtgaa gagaaagaac tctagggcaa agcggagcgg aagcggagca accaatttca      960

gcctgctgaa gcaggcaggc gatgtggagg agaaccctgg accaatggac aagatcctgg     1020

gcgcctcttt tctggtgctg tggctgcagc tgtgctgggt gtccggacag cagaaggaga     1080

agtctgatca gcagcaggtg aagcagtctc cccagagcct gatcgtgcag aagggcggca     1140

tcagcatcat caactgtgcc tacgagaata ccgccttcga ttactttccc tggtatcagc     1200

agttcccagg caagggaccc gccctgctga tcgcaatcag gcctgacgtg agcgagaaga     1260

aggagggccg cttcacaatc agctttaata agtccgccaa gcagttctcc ctgcacatca     1320

tggacagcca gcccggcgat tccgccacct acttttgtgc agcagaggca ggaaaccaca     1380

ggggctccac actgggccgg ctgtatttcg gcagaggcac ccagctgaca gtgtggccta     1440

acatccagaa tcccgagcct gccgtgtacc agctgaagga cccaagatcc caggattcta     1500

ccctgtgcct gttcacagac tttgattctc agatcaatgt gcctaagaca atggagagcg     1560

gcacctttat cacagacaag tgcgtgctgg acatgaaggc tatggactcc aagtctaacg     1620

gcgccatcgc ctggtctaat cagaccagct tcacatgcca ggatatcttt aaggagacaa     1680

acgccacata tccttcctct gacgtgccat gtgatgccac cctgacagag aagagcttcg     1740

agacagacat gaacctgaat tttcagaacc tgctggtcat cgtgctgcgg atcctgctgc     1800

tgaaggtggc cggcttcaat ctgctgatga cactgagact gtggagctcc tgagaattc      1859


<210>  47
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Met Ala Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp 
                325                 330                 335     


Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu Cys Trp 
            340                 345                 350         


Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln 
        355                 360                 365             


Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn 
    370                 375                 380                 


Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln 
385                 390                 395                 400 


Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val 
                405                 410                 415     


Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala 
            420                 425                 430         


Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala 
        435                 440                 445             


Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu 
    450                 455                 460                 


Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp Pro Asn 
465                 470                 475                 480 


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
                485                 490                 495     


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            500                 505                 510         


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
        515                 520                 525             


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    530                 535                 540                 


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
545                 550                 555                 560 


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                565                 570                 575     


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
            580                 585                 590         


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        595                 600                 605             


Met Thr Leu Arg Leu Trp Ser Ser 
    610                 615     


<210>  48
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Met Thr Glu Tyr Lys Leu Val Val 
            20                  25                  30          


Val Gly Ala Gly Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile 
        35                  40                  45              


Gln Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu 
    50                  55                  60                  


Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg 
65                  70                  


<210>  49
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Met Thr Glu Tyr Lys Leu Val Val 
            20                  25                  30          


Val Gly Ala Val Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile 
        35                  40                  45              


Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Cys Gly Val Gly Lys 
    50                  55                  60                  


Ser Ala Leu Thr Ile Gln Leu Ile Met Thr Glu Tyr Lys Leu Val Val 
65                  70                  75                  80  


Val Gly Ala Ala Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile 
                85                  90                  95      


Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Ser Gly Val Gly Lys 
            100                 105                 110         


Ser Ala Leu Thr Ile Gln Leu Ile Met Thr Glu Tyr Lys Leu Val Val 
        115                 120                 125             


Val Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile 
    130                 135                 140                 


Gln Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Arg Val Gly 
145                 150                 155                 160 


Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Met Thr Glu Tyr Lys Leu 
                165                 170                 175     


Val Val Val Gly Ala Gly Val Val Gly Lys Ser Ala Leu Thr Ile Gln 
            180                 185                 190         


Leu Ile Gln Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Arg 
        195                 200                 205             


Glu Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Glu Thr Cys Leu 
    210                 215                 220                 


Leu Asp Ile Leu Asp Thr Ala Gly Leu Glu Glu Tyr Ser Ala Met Arg 
225                 230                 235                 240 


Asp Gln Tyr Met Arg Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala 
                245                 250                 255     


Gly Lys Glu Glu Tyr Ser Ala Met Arg Asp Gln Tyr Met Arg Glu Thr 
            260                 265                 270         


Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly His Glu Glu Tyr Ser Ala 
        275                 280                 285             


Met Arg Asp Gln Tyr Met Arg 
    290                 295 


<210>  50
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  50

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  51
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro 
145 


<210>  52
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  53
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (257)..(257)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (259)..(259)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  53

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Xaa Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Xaa Val Xaa Xaa Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  54
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  Xaa is Ser or Cys

<400>  54

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  55
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  56
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  57
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280         


<210>  58
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  59
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu Gly Arg Leu 
            100                 105                 110         


Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp Pro 
        115                 120                 


<210>  60
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe 
        35                  40                  45              


Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr Leu Glu 
65                  70                  75                  80  


Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala Ala Gly 
                85                  90                  95      


Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  61
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Xaa is Thr or Cys

<220>
<221>  MISC_FEATURE
<222>  (236)..(236)
<223>  Xaa is Ser, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa is Met, Ala, Val, Leu, Ile, Pro, Phe, or Trp

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  Xaa is Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, or Trp

<400>  61

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu Gly Arg Leu 
            100                 105                 110         


Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp Pro Asn Ile Gln Asn 
        115                 120                 125             


Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser 
    130                 135                 140                 


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
145                 150                 155                 160 


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Xaa Val Leu Asp Met 
                165                 170                 175     


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
            180                 185                 190         


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
        195                 200                 205             


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
    210                 215                 220                 


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Xaa Val Xaa Xaa Leu 
225                 230                 235                 240 


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
                245                 250                 255     


Arg Leu Trp Ser Ser 
            260     


<210>  62
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  Xaa is Ser or Cys

<400>  62

Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe 
        35                  40                  45              


Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr Leu Glu 
65                  70                  75                  80  


Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala Ala Gly 
                85                  90                  95      


Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        115                 120                 125             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Xaa Thr Asp Pro Gln Ala Tyr 
                165                 170                 175     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    210                 215                 220                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285     


<210>  63
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu Gly Arg Leu 
            100                 105                 110         


Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp Pro Asn Ile Gln Asn 
        115                 120                 125             


Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser 
    130                 135                 140                 


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
145                 150                 155                 160 


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met 
                165                 170                 175     


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
            180                 185                 190         


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
        195                 200                 205             


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
    210                 215                 220                 


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu 
225                 230                 235                 240 


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
                245                 250                 255     


Arg Leu Trp Ser Ser 
            260     


<210>  64
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe 
        35                  40                  45              


Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr Leu Glu 
65                  70                  75                  80  


Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala Ala Gly 
                85                  90                  95      


Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        115                 120                 125             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr 
                165                 170                 175     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    210                 215                 220                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285     


<210>  65
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val Lys Gln Ser Pro Gln 
1               5                   10                  15      


Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile Ile Asn Cys Ala Tyr 
            20                  25                  30          


Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr Gln Gln Phe Pro Gly 
        35                  40                  45              


Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val Ser Glu Lys 
    50                  55                  60                  


Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys Ser Ala Lys Gln Phe 
65                  70                  75                  80  


Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp Ser Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser Thr Leu Gly Arg Leu 
            100                 105                 110         


Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp Pro Asn Ile Gln Asn 
        115                 120                 125             


Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser 
    130                 135                 140                 


Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys 
145                 150                 155                 160 


Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met 
                165                 170                 175     


Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln 
            180                 185                 190         


Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr 
        195                 200                 205             


Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe 
    210                 215                 220                 


Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu 
225                 230                 235                 240 


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
                245                 250                 255     


Arg Leu Trp Ser Ser 
            260     


<210>  66
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His Arg Ser Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe 
        35                  40                  45              


Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn Val Ser Thr Leu Glu 
65                  70                  75                  80  


Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Leu Ala Ala Gly 
                85                  90                  95      


Gly Tyr Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        115                 120                 125             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                165                 170                 175     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    210                 215                 220                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285     


<210>  67
<211>  616
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Met Ala Lys Ile Leu Gly Ala Ser Phe Leu Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Cys Trp Val Ser Gly Gln Gln Lys Glu Lys Ser Asp Gln Gln Gln Val 
            20                  25                  30          


Lys Gln Ser Pro Gln Ser Leu Ile Val Gln Lys Gly Gly Ile Ser Ile 
        35                  40                  45              


Ile Asn Cys Ala Tyr Glu Asn Thr Ala Phe Asp Tyr Phe Pro Trp Tyr 
    50                  55                  60                  


Gln Gln Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro 
65                  70                  75                  80  


Asp Val Ser Glu Lys Lys Glu Gly Arg Phe Thr Ile Ser Phe Asn Lys 
                85                  90                  95      


Ser Ala Lys Gln Phe Ser Leu His Ile Met Asp Ser Gln Pro Gly Asp 
            100                 105                 110         


Ser Ala Thr Tyr Phe Cys Ala Ala Glu Ala Gly Asn His Arg Gly Ser 
        115                 120                 125             


Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr Gln Leu Thr Val Trp 
    130                 135                 140                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
145                 150                 155                 160 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                165                 170                 175     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            180                 185                 190         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        195                 200                 205             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    210                 215                 220                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
225                 230                 235                 240 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                245                 250                 255     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            260                 265                 270         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly 
        275                 280                 285             


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
    290                 295                 300                 


Glu Asn Pro Gly Pro Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu 
305                 310                 315                 320 


Cys Leu Leu Gly Ala Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro 
                325                 330                 335     


Arg Tyr Leu Ile Lys Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser 
            340                 345                 350         


Pro Ile Ser Gly His Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly 
        355                 360                 365             


Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn 
    370                 375                 380                 


Lys Gly Asn Phe Pro Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser 
385                 390                 395                 400 


Arg Ser Glu Met Asn Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu 
                405                 410                 415     


Tyr Leu Cys Ala Ser Ser Leu Ala Ala Gly Gly Tyr Phe Asn Glu Gln 
            420                 425                 430         


Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn 
        435                 440                 445             


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
    450                 455                 460                 


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
465                 470                 475                 480 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
                485                 490                 495     


Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
            500                 505                 510         


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
        515                 520                 525             


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
    530                 535                 540                 


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
545                 550                 555                 560 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
                565                 570                 575     


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
            580                 585                 590         


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
        595                 600                 605             


Ala Met Val Lys Arg Lys Asn Ser 
    610                 615     


