
                                SEQUENCE LISTING

<110> Juno Therapeutics, Inc.

<120> BCMA-DIRECTED CHIMERIC ANTIGEN RECEPTOR
  T CELL COMPOSITIONS AND METHODS AND USES THEREOF
  

<130> 735042023540

<140> Not yet assigned    
<141> Concurrently herewith 

<150> US 62/975,731       
<151> 2020-02-12  

<160> 283

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> (4GS)3 linker

<400> 1
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3GS linker

<400> 2
Gly Gly Gly Ser
 1              


<210> 3
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4-1BB/CD3 zeta predicted splice acceptor site

<400> 3
gctgagagtc aagttttcca ggtccgccga cgctccagcc t                     41

<210> 4
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB-derived intracellular co-signaling sequence

<400> 4
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 5
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4-1BB-derived intracellular co-signaling sequence

<400> 5
aagcggggga gaaagaaact gctgtatatt ttcaaacagc cctttatgag acctgtgcag 60
actacccagg aggaagacgg atgcagctgt aggtttcccg aggaagagga aggaggctgt 120
gagctg                                                            126

<210> 6
<211> 126
<212> DNA
<213> Artificial Sequence

<220> 
<223> 4-1BB-derived intracellular co-signaling sequence

<400> 6
aagcggggca gaaagaagct gctctacatc ttcaagcagc ccttcatgcg gcccgtgcag 60
accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc 120
gagctg                                                            126

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4GS linker

<400> 7
Gly Gly Gly Gly Ser
 1               5  


<210> 8
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> Alternative CO/SSE spacer

<400> 8
gaatctaagt acggaccgcc ttgtcctcct tgtcccgctc ctcctgttgc cggaccttcc 60
gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg 120
acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ctggtatgtg 180
gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc 240
tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac 300
aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc 360
aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc 420
aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg 480
gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac 540
agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag 600
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa 660
agcctgagcc tgtctctggg caag                                        684

<210> 9
<211> 1959
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 9
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc cctgaggctg 60
tcttgcgcag ccagcggctt cacctttagc gactactata tgtcctggat cagacaggca 120
cctggcaagg gcctggagtg ggtgagctac atcagctcct ctggctccac aatctactat 180
gccgactctg tgaagggccg gtttaccatc agcagagata acgccaagaa ttccctgtat 240
ctgcagatga acagcctgag ggccgaggac acagccgtgt actattgcgc caaggtggac 300
ggcgattaca ccgaggatta ttggggccag ggcacactgg tgaccgtgag ctccggcggc 360
ggcggctctg gaggaggagg cagcggcgga ggaggctccc agtctgccct gacacagcca 420
gccagcgtgt ccggctctcc cggacagtcc atcacaatct cttgtaccgg ctctagctcc 480
gacgtgggca agtacaacct ggtgtcctgg tatcagcagc cccctggcaa ggcccctaag 540
ctgatcatct acgatgtgaa caagaggcca tctggcgtga gcaatcgctt cagcggctcc 600
aagtctggca ataccgccac actgaccatc agcggcctgc agggcgacga tgaggcagat 660
tactattgtt ctagctacgg cggcagcaga tcctacgtgt tcggcacagg caccaaggtg 720
accgtgctgg aatctaagta cggaccgcct tgtcctcctt gtcccgctcc tcctgttgcc 780
ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcaggacc 840
cctgaagtga cctgcgtggt ggtggatgtg tcccaagagg atcccgaggt gcagttcaac 900
tggtatgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagttc 960
cagagcacct acagagtggt gtccgtgctg acagtgctgc accaggattg gctgaacggc 1020
aaagagtaca agtgcaaggt gtccaacaag ggcctgccta gcagcatcga gaaaaccatc 1080
tccaaggcca agggccagcc aagagagccc caggtttaca cactgcctcc aagccaagag 1140
gaaatgacca agaatcaggt gtccctgaca tgcctggtca agggcttcta cccctccgat 1200
atcgccgtgg aatgggagag caatggccag cctgagaaca actacaagac cacacctcct 1260
gtgctggaca gcgacggcag tttcttcctg tatagtagac tcaccgtgga taaatcaaga 1320
tggcaagagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac 1380
acccagaaaa gcctgagcct gtctctgggc aagatgttct gggtgctcgt ggtcgttggc 1440
ggagtgctgg cctgttacag cctgctggtt accgtggcct tcatcatctt ttgggtcaag 1500
cggggcagaa agaagctgct ctacatcttc aagcagccct tcatgcggcc cgtgcagacc 1560
acacaagagg aagatggctg ctcctgcaga ttccccgagg aagaagaagg cggctgcgag 1620
ctgagagtga agttcagcag atccgccgac gctccagcct atcagcaggg ccaaaaccag 1680
ctgtacaacg agctgaacct ggggagaaga gaagagtacg acgtgctgga taagcggaga 1740
ggcagagatc ctgaaatggg cggcaagccc agacggaaga atcctcaaga gggcctgtat 1800
aatgagctgc agaaagacaa gatggccgag gcctacagcg agatcggaat gaagggcgag 1860
cgcagaagag gcaagggaca cgatggactg taccagggcc tgagcaccgc caccaaggat 1920
acctatgacg cactgcacat gcaggccctg ccacctaga                        1959

<210> 10
<211> 1950
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 10
gaggtgcagc tggtgcagag cggaggaggc ctggtgcagc ctggcaggtc cctgcgcctg 60
tcttgcaccg ccagcggctt cacatttggc gactatgcca tgtcctggtt caagcaggca 120
ccaggcaagg gcctggagtg ggtgggcttt atccgctcta aggcctacgg cggcaccaca 180
gagtatgccg ccagcgtgaa gggccggttc accatcagcc gggacgactc taagagcatc 240
gcctacctgc agatgaactc tctgaagacc gaggacacag ccgtgtacta ttgcgcagca 300
tggagcgccc caaccgatta ttggggccag ggcaccctgg tgacagtgag ctccggcggc 360
ggcggctctg gaggaggagg aagcggagga ggaggatccg acatccagat gacacagtcc 420
cctgcctttc tgtccgcctc tgtgggcgat agggtgaccg tgacatgtcg cgcctcccag 480
ggcatctcta actacctggc ctggtatcag cagaagcccg gcaatgcccc tcggctgctg 540
atctacagcg cctccaccct gcagagcgga gtgccctccc ggttcagagg aaccggctat 600
ggcacagagt tttctctgac catcgacagc ctgcagccag aggatttcgc cacatactat 660
tgtcagcagt cttacaccag ccggcagaca tttggccccg gcacaagact ggatatcaag 720
gagtctaaat acggaccgcc ttgtcctcct tgtcccgctc ctcctgttgc cggaccttcc 780
gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg 840
acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ctggtatgtg 900
gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc 960
tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac 1020
aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc 1080
aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc 1140
aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg 1200
gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac 1260
agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag 1320
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa 1380
agcctgagcc tgtctctggg caagatgttc tgggtgctcg tggtcgttgg cggagtgctg 1440
gcctgttaca gcctgctggt taccgtggcc ttcatcatct tttgggtcaa gcggggcaga 1500
aagaagctgc tctacatctt caagcagccc ttcatgcggc ccgtgcagac cacacaagag 1560
gaagatggct gctcctgcag attccccgag gaagaagaag gcggctgcga gctgagagtg 1620
aagttcagca gatccgccga cgctccagcc tatcagcagg gccaaaacca gctgtacaac 1680
gagctgaacc tggggagaag agaagagtac gacgtgctgg ataagcggag aggcagagat 1740
cctgaaatgg gcggcaagcc cagacggaag aatcctcaag agggcctgta taatgagctg 1800
cagaaagaca agatggccga ggcctacagc gagatcggaa tgaagggcga gcgcagaaga 1860
ggcaagggac acgatggact gtaccagggc ctgagcaccg ccaccaagga tacctatgac 1920
gcactgcaca tgcaggccct gccacctaga                                  1950

<210> 11
<211> 1953
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 11
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc tctgaggctg 60
agctgcgcag cctccggctt caccttttct gactactata tgagctggat caggcaggca 120
ccaggcaagg gcctggagtg ggtgtcttac atcagctcct ctggcagcac aatctactat 180
gccgactccg tgaagggcag gttcaccatc tctcgcgata acgccaagaa tagcctgtat 240
ctgcagatga actccctgcg ggccgaggat acagccgtgt actattgcgc caaggtggac 300
ggcccccctt cctttgatat ctggggccag ggcacaatgg tgaccgtgag ctccggagga 360
ggaggatccg gcggaggagg ctctggcggc ggcggctcta gctatgtgct gacccagcca 420
ccatccgtgt ctgtggcacc tggacagaca gcaaggatca cctgtggagc aaacaatatc 480
ggcagcaagt ccgtgcactg gtaccagcag aagcctggcc aggccccaat gctggtggtg 540
tatgacgatg acgatcggcc cagcggcatc cctgagagat tttctggcag caactccggc 600
aataccgcca cactgaccat ctctggagtg gaggcaggcg acgaggcaga ttacttctgt 660
cacctgtggg accggagcag agatcactac gtgttcggca caggcaccaa gctgaccgtg 720
ctggaatcta agtacggacc gccttgtcct ccttgtcccg ctcctcctgt tgccggacct 780
tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatcagcag gacccctgaa 840
gtgacctgcg tggtggtgga tgtgtcccaa gaggatcccg aggtgcagtt caactggtat 900
gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gttccagagc 960
acctacagag tggtgtccgt gctgacagtg ctgcaccagg attggctgaa cggcaaagag 1020
tacaagtgca aggtgtccaa caagggcctg cctagcagca tcgagaaaac catctccaag 1080
gccaagggcc agccaagaga gccccaggtt tacacactgc ctccaagcca agaggaaatg 1140
accaagaatc aggtgtccct gacatgcctg gtcaagggct tctacccctc cgatatcgcc 1200
gtggaatggg agagcaatgg ccagcctgag aacaactaca agaccacacc tcctgtgctg 1260
gacagcgacg gcagtttctt cctgtatagt agactcaccg tggataaatc aagatggcaa 1320
gagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag 1380
aaaagcctga gcctgtctct gggcaagatg ttctgggtgc tcgtggtcgt tggcggagtg 1440
ctggcctgtt acagcctgct ggttaccgtg gccttcatca tcttttgggt caagcggggc 1500
agaaagaagc tgctctacat cttcaagcag cccttcatgc ggcccgtgca gaccacacaa 1560
gaggaagatg gctgctcctg cagattcccc gaggaagaag aaggcggctg cgagctgaga 1620
gtgaagttca gcagatccgc cgacgctcca gcctatcagc agggccaaaa ccagctgtac 1680
aacgagctga acctggggag aagagaagag tacgacgtgc tggataagcg gagaggcaga 1740
gatcctgaaa tgggcggcaa gcccagacgg aagaatcctc aagagggcct gtataatgag 1800
ctgcagaaag acaagatggc cgaggcctac agcgagatcg gaatgaaggg cgagcgcaga 1860
agaggcaagg gacacgatgg actgtaccag ggcctgagca ccgccaccaa ggatacctat 1920
gacgcactgc acatgcaggc cctgccacct aga                              1953

<210> 12
<211> 1974
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 12
agctatgagc tgacacagcc tccaagcgcc tctggcacac ctggacagcg agtgacaatg 60
agctgtagcg gcaccagcag caacatcggc agccacagcg tgaactggta tcagcagctg 120
cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc 180
gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatttc tggactgcag 240
agcgaggacg aggccgacta ttattgtgcc gcctgggacg gctctctgaa cggccttgtt 300
tttggcggag gcaccaagct gacagtgctg ggatctagag gtggcggagg atctggcggc 360
ggaggaagcg gaggcggcgg atctcttgaa atggctgaag tgcagctggt gcagtctggc 420
gccgaagtga agaagcctgg cgagagcctg aagatcagct gcaaaggcag cggctacagc 480
ttcaccagct actggatcgg ctgggtccga cagatgcctg gcaaaggcct tgagtggatg 540
ggcatcatct accccggcga cagcgacacc agatacagcc ctagctttca gggccacgtg 600
accatcagcg ccgacaagtc tatcagcacc gcctacctgc agtggtccag cctgaaggcc 660
tctgacaccg ccatgtacta ctgcgccaga tactctggca gcttcgacaa ttggggccag 720
ggcacactgg tcaccgtgtc cagcgagtct aaatacggac cgccttgtcc tccttgtccc 780
gctcctcctg ttgccggacc ttccgtgttc ctgtttcctc caaagcctaa ggacaccctg 840
atgatcagca ggacccctga agtgacctgc gtggtggtgg atgtgtccca agaggatccc 900
gaggtgcagt tcaactggta tgtggacggc gtggaagtgc acaacgccaa gaccaagcct 960
agagaggaac agttccagag cacctacaga gtggtgtccg tgctgacagt gctgcaccag 1020
gattggctga acggcaaaga gtacaagtgc aaggtgtcca acaagggcct gcctagcagc 1080
atcgagaaaa ccatctccaa ggccaagggc cagccaagag agccccaggt ttacacactg 1140
cctccaagcc aagaggaaat gaccaagaat caggtgtccc tgacatgcct ggtcaagggc 1200
ttctacccct ccgatatcgc cgtggaatgg gagagcaatg gccagcctga gaacaactac 1260
aagaccacac ctcctgtgct ggacagcgac ggcagtttct tcctgtatag tagactcacc 1320
gtggataaat caagatggca agagggcaac gtgttcagct gcagcgtgat gcacgaggcc 1380
ctgcacaacc actacaccca gaaaagcctg agcctgtctc tgggcaagat gttctgggtg 1440
ctcgtggtcg ttggcggagt gctggcctgt tacagcctgc tggttaccgt ggccttcatc 1500
atcttttggg tcaagcgggg cagaaagaag ctgctctaca tcttcaagca gcccttcatg 1560
cggcccgtgc agaccacaca agaggaagat ggctgctcct gcagattccc cgaggaagaa 1620
gaaggcggct gcgagctgag agtgaagttc agcagatccg ccgacgctcc agcctatcag 1680
cagggccaaa accagctgta caacgagctg aacctgggga gaagagaaga gtacgacgtg 1740
ctggataagc ggagaggcag agatcctgaa atgggcggca agcccagacg gaagaatcct 1800
caagagggcc tgtataatga gctgcagaaa gacaagatgg ccgaggccta cagcgagatc 1860
ggaatgaagg gcgagcgcag aagaggcaag ggacacgatg gactgtacca gggcctgagc 1920
accgccacca aggataccta tgacgcactg cacatgcagg ccctgccacc taga       1974

<210> 13
<211> 1962
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 13
cagtctgccc tgacacagcc tgccagcgtt agtgctagtc ccggacagtc tatcgccatc 60
agctgtaccg gcaccagctc tgacgttggc tggtatcagc agcaccctgg caaggcccct 120
aagctgatga tctacgagga cagcaagagg cccagcggcg tgtccaatag attcagcggc 180
agcaagagcg gcaacaccgc cagcctgaca attagcggac tgcaggccga ggacgaggcc 240
gattactact gcagcagcaa cacccggtcc agcacactgg tttttggcgg aggcaccaag 300
ctgacagtgc tgggatctag aggtggcgga ggatctggcg gcggaggaag cggaggcggc 360
ggatctcttg aaatggctga agtgcagctg gtgcagtctg gcgccgagat gaagaaacct 420
ggcgcctctc tgaagctgag ctgcaaggcc agcggctaca ccttcatcga ctactacgtg 480
tactggatgc ggcaggcccc tggacaggga ctcgaatcta tgggctggat caaccccaat 540
agcggcggca ccaattacgc ccagaaattc cagggcagag tgaccatgac cagagacacc 600
agcatcagca ccgcctacat ggaactgagc cggctgagat ccgacgacac cgccatgtac 660
tactgcgcca gatctcagcg cgacggctac atggattatt ggggccaggg aaccctggtc 720
accgtgtcca gcgagtctaa atacggaccg ccttgtcctc cttgtcccgc tcctcctgtt 780
gccggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcagg 840
acccctgaag tgacctgcgt ggtggtggat gtgtcccaag aggatcccga ggtgcagttc 900
aactggtatg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag 960
ttccagagca cctacagagt ggtgtccgtg ctgacagtgc tgcaccagga ttggctgaac 1020
ggcaaagagt acaagtgcaa ggtgtccaac aagggcctgc ctagcagcat cgagaaaacc 1080
atctccaagg ccaagggcca gccaagagag ccccaggttt acacactgcc tccaagccaa 1140
gaggaaatga ccaagaatca ggtgtccctg acatgcctgg tcaagggctt ctacccctcc 1200
gatatcgccg tggaatggga gagcaatggc cagcctgaga acaactacaa gaccacacct 1260
cctgtgctgg acagcgacgg cagtttcttc ctgtatagta gactcaccgt ggataaatca 1320
agatggcaag agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac 1380
tacacccaga aaagcctgag cctgtctctg ggcaagatgt tctgggtgct cgtggtcgtt 1440
ggcggagtgc tggcctgtta cagcctgctg gttaccgtgg ccttcatcat cttttgggtc 1500
aagcggggca gaaagaagct gctctacatc ttcaagcagc ccttcatgcg gcccgtgcag 1560
accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc 1620
gagctgagag tgaagttcag cagatccgcc gacgctccag cctatcagca gggccaaaac 1680
cagctgtaca acgagctgaa cctggggaga agagaagagt acgacgtgct ggataagcgg 1740
agaggcagag atcctgaaat gggcggcaag cccagacgga agaatcctca agagggcctg 1800
tataatgagc tgcagaaaga caagatggcc gaggcctaca gcgagatcgg aatgaagggc 1860
gagcgcagaa gaggcaaggg acacgatgga ctgtaccagg gcctgagcac cgccaccaag 1920
gatacctatg acgcactgca catgcaggcc ctgccaccta ga                    1962

<210> 14
<211> 1959
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 14
cagtctgccc tgacacagcc tgccagcgtt agtgctagtc ccggacagtc tatcgccatc 60
agctgtaccg gcaccagctc tgacgttggc tggtatcagc agcaccctgg caaggcccct 120
aagctgatga tctacgagga cagcaagagg cccagcggcg tgtccaatag attcagcggc 180
agcaagagcg gcaacaccgc cagcctgaca attagcggac tgcaggccga ggacgaggcc 240
gattactact gcagcagcaa cacccggtcc agcacactgg tttttggcgg aggcaccaag 300
ctgacagtgc tgggatctag aggtggcgga ggatctggcg gcggaggaag cggaggcggc 360
ggatctcttg aaatggctga agtgcagctg gtgcagtctg gcgccgagat gaagaaacct 420
ggcgcctctc tgaagctgag ctgcaaggcc agcggctaca ccttcatcga ctactacgtg 480
tactggatgc ggcaggcccc tggacaggga ctcgaatcta tgggctggat caaccccaat 540
agcggcggca ccaattacgc ccagaaattc cagggcagag tgaccatgac cagagacacc 600
agcatcagca ccgcctacat ggaactgagc cggctgagat ccgacgacac cgccatgtac 660
tactgcgcca gatctcagcg cgacggctac atggattatt ggggccaggg aaccctggtc 720
accgtgtcca gcgagtctaa atacggaccg ccttgtcctc cttgtcccgc tcctcctgtt 780
gccggacctt ccgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcagg 840
acccctgaag tgacctgcgt ggtggtggat gtgtcccaag aggatcccga ggtgcagttc 900
aactggtatg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag 960
ttccagagca cctacagagt ggtgtccgtg ctgacagtgc tgcaccagga ttggctgaac 1020
ggcaaagagt acaagtgcaa ggtgtccaac aagggcctgc ctagcagcat cgagaaaacc 1080
atctccaagg ccaagggcca gccaagagag ccccaggttt acacactgcc tccaagccaa 1140
gaggaaatga ccaagaatca ggtgtccctg acatgcctgg tcaagggctt ctacccctcc 1200
gatatcgccg tggaatggga gagcaatggc cagcctgaga acaactacaa gaccacacct 1260
cctgtgctgg acagcgacgg cagtttcttc ctgtatagta gactcaccgt ggataaatca 1320
agatggcaag agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac 1380
tacacccaga aaagcctgag cctgtctctg ggcaagatgt tctgggtgct cgtggtcgtt 1440
ggcggagtgc tggcctgtta cagcctgctg gttaccgtgg ccttcatcat cttttgggtc 1500
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc 1560
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc 1620
tccagagtga agttcagcag atccgccgac gctccagcct atcagcaggg ccaaaaccag 1680
ctgtacaacg agctgaacct ggggagaaga gaagagtacg acgtgctgga taagcggaga 1740
ggcagagatc ctgaaatggg cggcaagccc agacggaaga atcctcaaga gggcctgtat 1800
aatgagctgc agaaagacaa gatggccgag gcctacagcg agatcggaat gaagggcgag 1860
cgcagaagag gcaagggaca cgatggactg taccagggcc tgagcaccgc caccaaggat 1920
acctatgacg cactgcacat gcaggccctg ccacctaga                        1959

<210> 15
<211> 653
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Asp Tyr Thr Glu Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser
    130                 135                 140                 
Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser
145                 150                 155                 160 
Asp Val Gly Lys Tyr Asn Leu Val Ser Trp Tyr Gln Gln Pro Pro Gly
                165                 170                 175     
Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly
            180                 185                 190         
Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu
        195                 200                 205             
Thr Ile Ser Gly Leu Gln Gly Asp Asp Glu Ala Asp Tyr Tyr Cys Ser
    210                 215                 220                 
Ser Tyr Gly Gly Ser Arg Ser Tyr Val Phe Gly Thr Gly Thr Lys Val
225                 230                 235                 240 
Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala
                245                 250                 255     
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285             
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
    290                 295                 300                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
305                 310                 315                 320 
Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
            340                 345                 350         
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        355                 360                 365             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
    370                 375                 380                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
385                 390                 395                 400 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                405                 410                 415     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            420                 425                 430         
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
        435                 440                 445             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    450                 455                 460                 
Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly
465                 470                 475                 480 
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                485                 490                 495     
Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln
            500                 505                 510         
Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
        515                 520                 525             
Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys
    530                 535                 540                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln
545                 550                 555                 560 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
                565                 570                 575     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg
            580                 585                 590         
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met
        595                 600                 605             
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
    610                 615                 620                 
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
625                 630                 635                 640 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                645                 650             


<210> 16
<211> 650
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 16
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Ala Trp Ser Ala Pro Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Phe Leu
    130                 135                 140                 
Ser Ala Ser Val Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln
145                 150                 155                 160 
Gly Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala
                165                 170                 175     
Pro Arg Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro
            180                 185                 190         
Ser Arg Phe Arg Gly Thr Gly Tyr Gly Thr Glu Phe Ser Leu Thr Ile
        195                 200                 205             
Asp Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
    210                 215                 220                 
Tyr Thr Ser Arg Gln Thr Phe Gly Pro Gly Thr Arg Leu Asp Ile Lys
225                 230                 235                 240 
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val
                245                 250                 255     
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        275                 280                 285             
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    450                 455                 460                 
Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu
465                 470                 475                 480 
Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                485                 490                 495     
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
            500                 505                 510         
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
        515                 520                 525             
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
    530                 535                 540                 
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn
545                 550                 555                 560 
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
                565                 570                 575     
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
            580                 585                 590         
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
        595                 600                 605             
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
    610                 615                 620                 
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
625                 630                 635                 640 
Ala Leu His Met Gln Ala Leu Pro Pro Arg
                645                 650 


<210> 17
<211> 651
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Pro Pro Ser Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser
    130                 135                 140                 
Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Ala Asn Asn Ile
145                 150                 155                 160 
Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
                165                 170                 175     
Met Leu Val Val Tyr Asp Asp Asp Asp Arg Pro Ser Gly Ile Pro Glu
            180                 185                 190         
Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser
        195                 200                 205             
Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys His Leu Trp Asp
    210                 215                 220                 
Arg Ser Arg Asp His Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val
225                 230                 235                 240 
Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro
                245                 250                 255     
Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            260                 265                 270         
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        275                 280                 285             
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    290                 295                 300                 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser
305                 310                 315                 320 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                325                 330                 335     
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            340                 345                 350         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        355                 360                 365             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    370                 375                 380                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
385                 390                 395                 400 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                405                 410                 415     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            420                 425                 430         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        435                 440                 445             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    450                 455                 460                 
Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val
465                 470                 475                 480 
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                485                 490                 495     
Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe
            500                 505                 510         
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg
        515                 520                 525             
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser
    530                 535                 540                 
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr
545                 550                 555                 560 
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys
                565                 570                 575     
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
            580                 585                 590         
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu
        595                 600                 605             
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly
    610                 615                 620                 
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
625                 630                 635                 640 
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                645                 650     


<210> 18
<211> 658
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 18
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Met Ser Cys Ser Gly Thr Ser Ser Asn Ile Gly Ser His
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu
                85                  90                  95      
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser
            100                 105                 110         
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
    130                 135                 140                 
Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser
145                 150                 155                 160 
Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly
                165                 170                 175     
Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr
            180                 185                 190         
Ser Pro Ser Phe Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile
        195                 200                 205             
Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
    210                 215                 220                 
Met Tyr Tyr Cys Ala Arg Tyr Ser Gly Ser Phe Asp Asn Trp Gly Gln
225                 230                 235                 240 
Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe
            260                 265                 270         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
        275                 280                 285             
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
    290                 295                 300                 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
305                 310                 315                 320 
Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr
                325                 330                 335     
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
            340                 345                 350         
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
        355                 360                 365             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
    370                 375                 380                 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
385                 390                 395                 400 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                405                 410                 415     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
            420                 425                 430         
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu
        435                 440                 445             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
    450                 455                 460                 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val
465                 470                 475                 480 
Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                485                 490                 495     
Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu
            500                 505                 510         
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
        515                 520                 525             
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
    530                 535                 540                 
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln
545                 550                 555                 560 
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
                565                 570                 575     
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
            580                 585                 590         
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
        595                 600                 605             
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
    610                 615                 620                 
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
625                 630                 635                 640 
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
                645                 650                 655     
Pro Arg
        


<210> 19
<211> 654
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 19
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Ala Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Trp Tyr
            20                  25                  30          
Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser
        35                  40                  45              
Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly
    50                  55                  60                  
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala
65                  70                  75                  80  
Asp Tyr Tyr Cys Ser Ser Asn Thr Arg Ser Ser Thr Leu Val Phe Gly
                85                  90                  95      
Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val
        115                 120                 125             
Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala Ser Leu
    130                 135                 140                 
Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Tyr Tyr Val
145                 150                 155                 160 
Tyr Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Ser Met Gly Trp
                165                 170                 175     
Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly
            180                 185                 190         
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu
        195                 200                 205             
Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg
    210                 215                 220                 
Ser Gln Arg Asp Gly Tyr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                245                 250                 255     
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        275                 280                 285             
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
305                 310                 315                 320 
Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
            340                 345                 350         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            420                 425                 430         
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    450                 455                 460                 
Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val
465                 470                 475                 480 
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                485                 490                 495     
Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys
            500                 505                 510         
Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys
        515                 520                 525             
Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val
    530                 535                 540                 
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn
545                 550                 555                 560 
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
                565                 570                 575     
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
            580                 585                 590         
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
        595                 600                 605             
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
    610                 615                 620                 
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
625                 630                 635                 640 
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                645                 650                 


<210> 20
<211> 653
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-BCMA CAR

<400> 20
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Ala Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Trp Tyr
            20                  25                  30          
Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser
        35                  40                  45              
Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly
    50                  55                  60                  
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala
65                  70                  75                  80  
Asp Tyr Tyr Cys Ser Ser Asn Thr Arg Ser Ser Thr Leu Val Phe Gly
                85                  90                  95      
Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val
        115                 120                 125             
Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala Ser Leu
    130                 135                 140                 
Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Tyr Tyr Val
145                 150                 155                 160 
Tyr Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Ser Met Gly Trp
                165                 170                 175     
Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly
            180                 185                 190         
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu
        195                 200                 205             
Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg
    210                 215                 220                 
Ser Gln Arg Asp Gly Tyr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                245                 250                 255     
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            260                 265                 270         
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        275                 280                 285             
Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val
    290                 295                 300                 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
305                 310                 315                 320 
Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                325                 330                 335     
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly
            340                 345                 350         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        355                 360                 365             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr
    370                 375                 380                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
385                 390                 395                 400 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                405                 410                 415     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            420                 425                 430         
Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe
        435                 440                 445             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    450                 455                 460                 
Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val
465                 470                 475                 480 
Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                485                 490                 495     
Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
            500                 505                 510         
Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
        515                 520                 525             
Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys
    530                 535                 540                 
Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln
545                 550                 555                 560 
Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu
                565                 570                 575     
Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg
            580                 585                 590         
Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met
        595                 600                 605             
Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly
    610                 615                 620                 
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp
625                 630                 635                 640 
Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
                645                 650             


<210> 21
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA epitope

<400> 21
Tyr Phe Asp Ser Leu
 1               5  


<210> 22
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 CDR-L1

<400> 22
Thr Gly Ser Ser Ser Asp Val Gly Lys Tyr Asn Leu Val Ser
 1               5                  10                  


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 CDR-L2

<400> 23
Asp Val Asn Lys Arg Pro Ser
 1               5          


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 CDR-L3

<400> 24
Ser Ser Tyr Gly Gly Ser Arg Ser Tyr Val
 1               5                  10  


<210> 25
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 predicted splice acceptor site

<400> 25
ggctgattat tattgtagct catatggagg tagtaggtct t                     41

<210> 26
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 predicted splice acceptor site

<400> 26
ctactacatg agctggatcc gccaggctcc agggaagggg c                     41

<210> 27
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 predicted splice acceptor site (O/SSE)

<400> 27
ctactatatg tcctggatca gacaggcacc tggcaagggc c                     41

<210> 28
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 predicted splice acceptor site (O/SSE)

<400> 28
ggcagattac tattgttcta gctacggcgg cagcagatcc t                     41

<210> 29
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 scFv

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Asp Tyr Thr Glu Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser
    130                 135                 140                 
Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser
145                 150                 155                 160 
Asp Val Gly Lys Tyr Asn Leu Val Ser Trp Tyr Gln Gln Pro Pro Gly
                165                 170                 175     
Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly
            180                 185                 190         
Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu
        195                 200                 205             
Thr Ile Ser Gly Leu Gln Gly Asp Asp Glu Ala Asp Tyr Tyr Cys Ser
    210                 215                 220                 
Ser Tyr Gly Gly Ser Arg Ser Tyr Val Phe Gly Thr Gly Thr Lys Val
225                 230                 235                 240 
Thr Val Leu
            


<210> 30
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 scFv

<400> 30
gaagtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct 120
ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac 180
gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat 240
ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gaaagtagac 300
ggagactaca cagaggacta ctggggccag ggaaccctgg tcaccgtctc ctcaggtgga 360
ggcggttcag gcggaggtgg ctctggcggt ggcggatcgc agtctgccct gactcagcct 420
gcctccgtgt ctgggtctcc tggacagtcg atcactatct cctgcactgg aagcagcagt 480
gatgttggca aatataatct tgtctcctgg taccaacagc ccccaggcaa agcccccaag 540
ctcataattt atgacgtcaa taagcggccc tcaggggttt ctaatcgctt ctctggctcc 600
aagtctggca acacggccac cctgacaatc tctgggctcc agggtgacga cgaggctgat 660
tattattgta gctcatatgg aggtagtagg tcttatgtct tcggaactgg gaccaaggtg 720
accgtccta                                                         729

<210> 31
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-23 scFv

<400> 31
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc cctgaggctg 60
tcttgcgcag ccagcggctt cacctttagc gactactata tgtcctggat cagacaggca 120
cctggcaagg gcctggagtg ggtgagctac atcagctcct ctggctccac aatctactat 180
gccgactctg tgaagggccg gtttaccatc agcagagata acgccaagaa ttccctgtat 240
ctgcagatga acagcctgag ggccgaggac acagccgtgt actattgcgc caaggtggac 300
ggcgattaca ccgaggatta ttggggccag ggcacactgg tgaccgtgag ctccggcggc 360
ggcggctctg gaggaggagg cagcggcgga ggaggctccc agtctgccct gacacagcca 420
gccagcgtgt ccggctctcc cggacagtcc atcacaatct cttgtaccgg ctctagctcc 480
gacgtgggca agtacaacct ggtgtcctgg tatcagcagc cccctggcaa ggcccctaag 540
ctgatcatct acgatgtgaa caagaggcca tctggcgtga gcaatcgctt cagcggctcc 600
aagtctggca ataccgccac actgaccatc agcggcctgc agggcgacga tgaggcagat 660
tactattgtt ctagctacgg cggcagcaga tcctacgtgt tcggcacagg caccaaggtg 720
accgtgctg                                                         729

<210> 32
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 VH Chain

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Asp Tyr Thr Glu Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 33
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 VL Chain

<400> 33
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Val Gly Lys Tyr
            20                  25                  30          
Asn Leu Val Ser Trp Tyr Gln Gln Pro Pro Gly Lys Ala Pro Lys Leu
        35                  40                  45              
Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Leu
65                  70                  75                  80  
Gln Gly Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Gly Ser
                85                  90                  95      
Arg Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105                 110 


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23, -26 CDR-H1 (aa) Kabat numbering

<400> 34
Asp Tyr Tyr Met Ser
 1               5  


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23, -26 CDR-H2 (aa) Kabat numbering

<400> 35
Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-23 CDR-H3 (aa)

<400> 36
Val Asp Gly Asp Tyr Thr Glu Asp Tyr
 1               5                  


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-H1 (aa) Kabat numbering

<400> 37
Asp Tyr Ala Met Ser
 1               5  


<210> 38
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-H2 (aa) Kabat numbering

<400> 38
Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser
 1               5                  10                  15      
Val Lys Gly
            


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-H3 (aa)

<400> 39
Trp Ser Ala Pro Thr Asp Tyr
 1               5          


<210> 40
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-L1 (aa)

<400> 40
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala
 1               5                  10      


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-L2 (aa)

<400> 41
Ser Ala Ser Thr Leu Gln Ser
 1               5          


<210> 42
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 CDR-L3 (aa)

<400> 42
Gln Gln Ser Tyr Thr Ser Arg Gln Thr
 1               5                  


<210> 43
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site

<400> 43
ctatgccatg tcctggttca ggcaggcacc aggcaagggc c                     41

<210> 44
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site

<400> 44
gtccgcctct gtgggcgata gggtgaccgt gacatgtcgc g                     41

<210> 45
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site

<400> 45
gtgggcttta tccgctctaa ggcctacggc ggcaccacag a                     41

<210> 46
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site

<400> 46
gtgacatgtc gcgcctccca gggcatctct aactacctgg c                     41

<210> 47
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site

<400> 47
tacagcgcct ccaccctgca gagcggagtg ccctcccggt t                     41

<210> 48
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 predicted splice acceptor site (O/SSE)

<400> 48
ctatgccatg tcctggttca agcaggcacc aggcaagggc c                     41

<210> 49
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 scFv sequence

<400> 49
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Ala Trp Ser Ala Pro Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Phe Leu
    130                 135                 140                 
Ser Ala Ser Val Gly Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln
145                 150                 155                 160 
Gly Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala
                165                 170                 175     
Pro Arg Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro
            180                 185                 190         
Ser Arg Phe Arg Gly Thr Gly Tyr Gly Thr Glu Phe Ser Leu Thr Ile
        195                 200                 205             
Asp Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
    210                 215                 220                 
Tyr Thr Ser Arg Gln Thr Phe Gly Pro Gly Thr Arg Leu Asp Ile Lys
225                 230                 235                 240 


<210> 50
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 scFv

<400> 50
gaggtgcagc tggtgcagag cggaggaggc ctggtgcagc ctggcaggtc cctgcgcctg 60
tcttgcaccg ccagcggctt cacatttggc gactatgcca tgtcctggtt caggcaggca 120
ccaggcaagg gcctggagtg ggtgggcttt atccgctcta aggcctacgg cggcaccaca 180
gagtatgccg ccagcgtgaa gggccggttc accatcagcc gggacgactc taagagcatc 240
gcctacctgc agatgaactc tctgaagacc gaggacacag ccgtgtacta ttgcgcagca 300
tggagcgccc caaccgatta ttggggccag ggcaccctgg tgacagtgag ctccggcggc 360
ggcggctctg gaggaggagg aagcggagga ggaggatccg acatccagat gacacagtcc 420
cctgcctttc tgtccgcctc tgtgggcgat agggtgaccg tgacatgtcg cgcctcccag 480
ggcatctcta actacctggc ctggtatcag cagaagcccg gcaatgcccc tcggctgctg 540
atctacagcg cctccaccct gcagagcgga gtgccctccc ggttcagagg aaccggctat 600
ggcacagagt tttctctgac catcgacagc ctgcagccag aggatttcgc cacatactat 660
tgtcagcagt cttacaccag ccggcagaca tttggccccg gcacaagact ggatatcaag 720


<210> 51
<211> 720
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-25 scFv (nt) (O/SSE)

<400> 51
gaggtgcagc tggtgcagag cggaggaggc ctggtgcagc ctggcaggtc cctgcgcctg 60
tcttgcaccg ccagcggctt cacatttggc gactatgcca tgtcctggtt caagcaggca 120
ccaggcaagg gcctggagtg ggtgggcttt atccgctcta aggcctacgg cggcaccaca 180
gagtatgccg ccagcgtgaa gggccggttc accatcagcc gggacgactc taagagcatc 240
gcctacctgc agatgaactc tctgaagacc gaggacacag ccgtgtacta ttgcgcagca 300
tggagcgccc caaccgatta ttggggccag ggcaccctgg tgacagtgag ctccggcggc 360
ggcggctctg gaggaggagg aagcggagga ggaggatccg acatccagat gacacagtcc 420
cctgcctttc tgtccgcctc tgtgggcgat agggtgaccg tgacatgtcg cgcctcccag 480
ggcatctcta actacctggc ctggtatcag cagaagcccg gcaatgcccc tcggctgctg 540
atctacagcg cctccaccct gcagagcgga gtgccctccc ggttcagagg aaccggctat 600
ggcacagagt tttctctgac catcgacagc ctgcagccag aggatttcgc cacatactat 660
tgtcagcagt cttacaccag ccggcagaca tttggccccg gcacaagact ggatatcaag 720


<210> 52
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 VH chain

<400> 52
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr
            20                  25                  30          
Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Ala Trp Ser Ala Pro Thr Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 53
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-25 VL chain

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ala Phe Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Val Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly
    50                  55                  60                  
Thr Gly Tyr Gly Thr Glu Phe Ser Leu Thr Ile Asp Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Arg Gln
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Arg Leu Asp Ile Lys
            100                 105         


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 CDR-H3

<400> 54
Val Asp Gly Pro Pro Ser Phe Asp Ile
 1               5                  


<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 CDR-L1

<400> 55
Gly Ala Asn Asn Ile Gly Ser Lys Ser Val His
 1               5                  10      


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 CDR-L2

<400> 56
Asp Asp Asp Asp Arg Pro Ser
 1               5          


<210> 57
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 CDR-L3

<400> 57
His Leu Trp Asp Arg Ser Arg Asp His Tyr Val
 1               5                  10      


<210> 58
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 scFv sequence

<400> 58
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Pro Pro Ser Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser
    130                 135                 140                 
Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Ala Asn Asn Ile
145                 150                 155                 160 
Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro
                165                 170                 175     
Met Leu Val Val Tyr Asp Asp Asp Asp Arg Pro Ser Gly Ile Pro Glu
            180                 185                 190         
Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser
        195                 200                 205             
Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys His Leu Trp Asp
    210                 215                 220                 
Arg Ser Arg Asp His Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val
225                 230                 235                 240 
Leu
    


<210> 59
<211> 723
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-26 scFv

<400> 59
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc tctgaggctg 60
agctgcgcag cctccggctt caccttttct gactactata tgagctggat caggcaggca 120
ccaggcaagg gcctggagtg ggtgtcttac atcagctcct ctggcagcac aatctactat 180
gccgactccg tgaagggcag gttcaccatc tctcgcgata acgccaagaa tagcctgtat 240
ctgcagatga actccctgcg ggccgaggat acagccgtgt actattgcgc caaggtggac 300
ggcccccctt cctttgatat ctggggccag ggcacaatgg tgaccgtgag ctccggagga 360
ggaggatccg gcggaggagg ctctggcggc ggcggctcta gctatgtgct gacccagcca 420
ccatccgtgt ctgtggcacc tggacagaca gcaaggatca cctgtggagc aaacaatatc 480
ggcagcaagt ccgtgcactg gtaccagcag aagcctggcc aggccccaat gctggtggtg 540
tatgacgatg acgatcggcc cagcggcatc cctgagagat tttctggcag caactccggc 600
aataccgcca cactgaccat ctctggagtg gaggcaggcg acgaggcaga ttacttctgt 660
cacctgtggg accggagcag agatcactac gtgttcggca caggcaccaa gctgaccgtg 720
ctg                                                               723

<210> 60
<211> 723
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-26 scFv (nt) (O/SSE)

<400> 60
gaggtgcagc tggtggagtc cggaggaggc ctggtgaagc caggaggctc tctgaggctg 60
agctgcgcag cctccggctt caccttttct gactactata tgagctggat caggcaggca 120
ccaggcaagg gcctggagtg ggtgtcttac atcagctcct ctggcagcac aatctactat 180
gccgactccg tgaagggcag gttcaccatc tctcgcgata acgccaagaa tagcctgtat 240
ctgcagatga actccctgcg ggccgaggat acagccgtgt actattgcgc caaggtggac 300
ggcccccctt cctttgatat ctggggccag ggcacaatgg tgaccgtgag ctccggagga 360
ggaggatccg gcggaggagg ctctggcggc ggcggctcta gctatgtgct gacccagcca 420
ccatccgtgt ctgtggcacc tggacagaca gcaaggatca cctgtggagc aaacaatatc 480
ggcagcaagt ccgtgcactg gtaccagcag aagcctggcc aggccccaat gctggtggtg 540
tatgacgatg acgatcggcc cagcggcatc cctgagagat tttctggcag caactccggc 600
aataccgcca cactgaccat ctctggagtg gaggcaggcg acgaggcaga ttacttctgt 660
cacctgtggg accggagcag agatcactac gtgttcggca caggcaccaa gctgaccgtg 720
ctg                                                               723

<210> 61
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 VH Chain

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Val Asp Gly Pro Pro Ser Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 62
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-26 VL Chain

<400> 62
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Ala Asn Asn Ile Gly Ser Lys Ser Val
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Leu Val Val Tyr
        35                  40                  45              
Asp Asp Asp Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Phe Cys His Leu Trp Asp Arg Ser Arg Asp His
                85                  90                  95      
Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105             


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H1

<400> 63
Gly Tyr Ser Phe Thr Ser Tyr Trp
 1               5              


<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H1 (aa) - AbM numbering

<400> 64
Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly
 1               5                  10  


<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H1 (aa) - Chothia numbering

<400> 65
Gly Tyr Ser Phe Thr Ser Tyr
 1               5          


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H1 (aa) - Kabat numbering

<400> 66
Ser Tyr Trp Ile Gly
 1               5  


<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H2 (aa)

<400> 67
Ile Tyr Pro Gly Asp Ser Asp Thr
 1               5              


<210> 68
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H2 (aa) - AbM numbering

<400> 68
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg
 1               5                  10  


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H2 (aa) - Chothia numbering

<400> 69
Tyr Pro Gly Asp Ser Asp
 1               5      


<210> 70
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H2 (aa) - Kabat numbering

<400> 70
Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln
 1               5                  10                  15      
Gly
    


<210> 71
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H3 (aa)

<400> 71
Ala Arg Tyr Ser Gly Ser Phe Asp Asn
 1               5                  


<210> 72
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-H3 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 72
Tyr Ser Gly Ser Phe Asp Asn
 1               5          


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-L1 (aa)

<400> 73
Ser Ser Asn Ile Gly Ser His Ser
 1               5              


<210> 74
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-L1 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 74
Ser Gly Thr Ser Ser Asn Ile Gly Ser His Ser Val Asn
 1               5                  10              


<210> 75
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-L2 (aa)

<400> 75
Thr Asn Asn
 1          


<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-L2 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 76
Thr Asn Asn Gln Arg Pro Ser
 1               5          


<210> 77
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 CDR-L3 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 77
Ala Ala Trp Asp Gly Ser Leu Asn Gly Leu Val
 1               5                  10      


<210> 78
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 predicted splice acceptor site

<400> 78
ctggccatca gtggcctcca gtctgaggat gaggctgatt a                     41

<210> 79
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 predicted splice acceptor site

<400> 79
agatacagcc cgtccttcca aggccacgtc accatctcag c                     41

<210> 80
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 predicted splice acceptor site (O/SSE)

<400> 80
ctggctattt ctggactgca gagcgaggac gaggccgact a                     41

<210> 81
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 predicted splice acceptor site (O/SSE)

<400> 81
agatacagcc ctagctttca gggccacgtg accatcagcg c                     41

<210> 82
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 scFv

<400> 82
tcctatgagc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatg 60
tcttgttctg gaaccagctc caacatcgga agtcactctg taaactggta ccagcagctc 120
ccaggaacgg cccccaaact cctcatctat actaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggcctccag 240
tctgaggatg aggctgatta ttactgtgca gcatgggatg gcagcctgaa tggtctggta 300
ttcggcggag ggaccaagct gaccgtccta ggttctagag gtggtggtgg tagcggcggc 360
ggcggctctg gtggtggtgg atccctcgag atggccgagg tgcagctggt gcagtctgga 420
gcagaggtga aaaagcccgg ggagtctctg aagatctcct gtaagggttc tggatacagc 480
tttaccagct actggatcgg ctgggtgcgc cagatgcccg ggaaaggcct ggagtggatg 540
gggatcatct atcctggtga ctctgatacc agatacagcc cgtccttcca aggccacgtc 600
accatctcag ctgacaagtc catcagcact gcctacctgc agtggagcag cctgaaggcc 660
tcggacaccg ccatgtatta ctgtgcgcgc tactctggtt ctttcgataa ctggggtcaa 720
ggtactctgg tgaccgtctc ctca                                        744

<210> 83
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 scFv

<400> 83
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Met Ser Cys Ser Gly Thr Ser Ser Asn Ile Gly Ser His
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu
                85                  90                  95      
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser
            100                 105                 110         
Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125             
Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
    130                 135                 140                 
Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser
145                 150                 155                 160 
Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly
                165                 170                 175     
Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr
            180                 185                 190         
Ser Pro Ser Phe Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile
        195                 200                 205             
Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala
    210                 215                 220                 
Met Tyr Tyr Cys Ala Arg Tyr Ser Gly Ser Phe Asp Asn Trp Gly Gln
225                 230                 235                 240 
Gly Thr Leu Val Thr Val Ser Ser
                245             


<210> 84
<211> 744
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 scFv (nt) (O/SSE)

<400> 84
agctatgagc tgacacagcc tccaagcgcc tctggcacac ctggacagcg agtgacaatg 60
agctgtagcg gcaccagcag caacatcggc agccacagcg tgaactggta tcagcagctg 120
cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc 180
gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatttc tggactgcag 240
agcgaggacg aggccgacta ttattgtgcc gcctgggacg gctctctgaa cggccttgtt 300
tttggcggag gcaccaagct gacagtgctg ggatctagag gtggcggagg atctggcggc 360
ggaggaagcg gaggcggcgg atctcttgaa atggctgaag tgcagctggt gcagtctggc 420
gccgaagtga agaagcctgg cgagagcctg aagatcagct gcaaaggcag cggctacagc 480
ttcaccagct actggatcgg ctgggtccga cagatgcctg gcaaaggcct tgagtggatg 540
ggcatcatct accccggcga cagcgacacc agatacagcc ctagctttca gggccacgtg 600
accatcagcg ccgacaagtc tatcagcacc gcctacctgc agtggtccag cctgaaggcc 660
tctgacaccg ccatgtacta ctgcgccaga tactctggca gcttcgacaa ttggggccag 720
ggcacactgg tcaccgtgtc cagc                                        744

<210> 85
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 VH chain

<400> 85
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Ser Gly Ser Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 86
<211> 350
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 VH chain

<400> 86
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc 60
tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg 120
cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac 180
agcccgtcct tccaaggcca cgtcaccatc tcagctgaca agtccatcag cactgcctac 240
ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gcgctactct 300
ggttctttcg ataactgggg tcaaggtact ctggtgaccg tctcctcagc            350

<210> 87
<211> 348
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 VH chain (nt) (O/SSE)

<400> 87
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaagc ctggcgagag cctgaagatc 60
agctgcaaag gcagcggcta cagcttcacc agctactgga tcggctgggt ccgacagatg 120
cctggcaaag gccttgagtg gatgggcatc atctaccccg gcgacagcga caccagatac 180
agccctagct ttcagggcca cgtgaccatc agcgccgaca agtctatcag caccgcctac 240
ctgcagtggt ccagcctgaa ggcctctgac accgccatgt actactgcgc cagatactct 300
ggcagcttcg acaattgggg ccagggcaca ctggtcaccg tgtccagc              348

<210> 88
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-52 VL chain

<400> 88
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Met Ser Cys Ser Gly Thr Ser Ser Asn Ile Gly Ser His
            20                  25                  30          
Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu
                85                  90                  95      
Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 89
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 VL chain

<400> 89
tcctatgagc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatg 60
tcttgttctg gaaccagctc caacatcgga agtcactctg taaactggta ccagcagctc 120
ccaggaacgg cccccaaact cctcatctat actaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tggcctccag 240
tctgaggatg aggctgatta ttactgtgca gcatgggatg gcagcctgaa tggtctggta 300
ttcggcggag ggaccaagct gaccgtccta ggt                              333

<210> 90
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-52 VL chain (nt) (O/SSE)

<400> 90
agctatgagc tgacacagcc tccaagcgcc tctggcacac ctggacagcg agtgacaatg 60
agctgtagcg gcaccagcag caacatcggc agccacagcg tgaactggta tcagcagctg 120
cctggcacag cccctaaact gctgatctac accaacaacc agcggcctag cggcgtgccc 180
gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatttc tggactgcag 240
agcgaggacg aggccgacta ttattgtgcc gcctgggacg gctctctgaa cggccttgtt 300
tttggcggag gcaccaagct gacagtgctg gga                              333

<210> 91
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-52-scFV-mFc BCMA binding epitope 1

<400> 91
Gln Asn Glu Tyr Phe
 1               5  


<210> 92
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-52-scFV-mFc BCMA binding epitope 2

<400> 92
Cys Ile Pro Cys Gln Leu
 1               5      


<210> 93
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-52-scFV-mFc BCMA binding epitope 3

<400> 93
Cys Gln Arg Tyr Cys
 1               5  


<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H1 (aa)

<400> 94
Gly Tyr Thr Phe Ile Asp Tyr Tyr
 1               5              


<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H1 (aa) - AbM numbering

<400> 95
Gly Tyr Thr Phe Ile Asp Tyr Tyr Val Tyr
 1               5                  10  


<210> 96
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H1 (aa) - Chothia numbering

<400> 96
Gly Tyr Thr Phe Ile Asp Tyr
 1               5          


<210> 97
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H1 (aa) - Kabat numbering

<400> 97
Asp Tyr Tyr Val Tyr
 1               5  


<210> 98
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H2 (aa)

<400> 98
Ile Asn Pro Asn Ser Gly Gly Thr
 1               5              


<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H2 (aa) - AbM numbering

<400> 99
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn
 1               5                  10  


<210> 100
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H2 (aa) - Chothia numbering

<400> 100
Asn Pro Asn Ser Gly Gly
 1               5      


<210> 101
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H2 (aa) - Kabat numbering

<400> 101
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Gly
    


<210> 102
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H3 (aa)

<400> 102
Ala Arg Ser Gln Arg Asp Gly Tyr Met Asp Tyr
 1               5                  10      


<210> 103
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-H3 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 103
Ser Gln Arg Asp Gly Tyr Met Asp Tyr
 1               5                  


<210> 104
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-L1 (aa)

<400> 104
Ile Ser Cys Thr Gly Thr Ser Ser Asp
 1               5                  


<210> 105
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-L1 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 105
Thr Gly Thr Ser Ser Asp Val Gly
 1               5              


<210> 106
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-L2 (aa)

<400> 106
Glu Asp Ser
 1          


<210> 107
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-L2 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 107
Glu Asp Ser Lys Arg Pro Ser
 1               5          


<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 CDR-L3 (aa) - Kabat, Chothia, and AbM
      numbering

<400> 108
Ser Ser Asn Thr Arg Ser Ser Thr Leu Val
 1               5                  10  


<210> 109
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 predicted splice acceptor site

<400> 109
gccctcaggg gtttctaatc gcttctctgg ctccaagtct g                     41

<210> 110
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 predicted splice acceptor site

<400> 110
cgaggctgat tattactgca gctcaaatac aagaagcagc a                     41

<210> 111
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 predicted splice acceptor site (O/SSE)

<400> 111
cgaggccgat tactactgca gcagcaacac ccggtccagc a                     41

<210> 112
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 predicted splice acceptor site (O/SSE)

<400> 112
gcccagcggc gtgtccaata gattcagcgg cagcaagagc g                     41

<210> 113
<211> 732
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 scFv

<400> 113
caatctgccc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcgccatc 60
tcctgcactg gaaccagcag tgacgttggt tggtatcaac agcacccagg caaagccccc 120
aaactcatga tttatgagga cagtaagcgg ccctcagggg tttctaatcg cttctctggc 180
tccaagtctg gcaacacggc ctccctgacc atctctgggc tccaggctga ggacgaggct 240
gattattact gcagctcaaa tacaagaagc agcactttgg tgttcggcgg agggaccaag 300
ctgaccgtcc taggttctag aggtggtggt ggtagcggcg gcggcggctc tggtggtggt 360
ggatccctcg agatggccga agtgcagctg gtgcagtctg gggctgagat gaagaagcct 420
ggggcctcac tgaagctctc ctgcaaggct tctggataca ccttcatcga ctactatgta 480
tactggatgc gacaggcccc tggacaaggg cttgagtcca tgggatggat caaccctaac 540
agtggtggca caaactatgc acagaagttt cagggcaggg tcaccatgac cagggacacg 600
tccatcagca cagcctacat ggagctgagc aggctgagat ctgacgacac cgccatgtat 660
tactgtgcgc gctcccagcg tgacggttac atggattact ggggtcaagg tactctggtg 720
accgtctcct ca                                                     732

<210> 114
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 scFv

<400> 114
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Ala Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Trp Tyr
            20                  25                  30          
Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser
        35                  40                  45              
Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly
    50                  55                  60                  
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala
65                  70                  75                  80  
Asp Tyr Tyr Cys Ser Ser Asn Thr Arg Ser Ser Thr Leu Val Phe Gly
                85                  90                  95      
Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Arg Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Glu Val
        115                 120                 125             
Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala Ser Leu
    130                 135                 140                 
Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Tyr Tyr Val
145                 150                 155                 160 
Tyr Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Ser Met Gly Trp
                165                 170                 175     
Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly
            180                 185                 190         
Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu
        195                 200                 205             
Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys Ala Arg
    210                 215                 220                 
Ser Gln Arg Asp Gly Tyr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ser
                


<210> 115
<211> 732
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 scFv (nt) (O/SSE)

<400> 115
cagtctgccc tgacacagcc tgccagcgtt agtgctagtc ccggacagtc tatcgccatc 60
agctgtaccg gcaccagctc tgacgttggc tggtatcagc agcaccctgg caaggcccct 120
aagctgatga tctacgagga cagcaagagg cccagcggcg tgtccaatag attcagcggc 180
agcaagagcg gcaacaccgc cagcctgaca attagcggac tgcaggccga ggacgaggcc 240
gattactact gcagcagcaa cacccggtcc agcacactgg tttttggcgg aggcaccaag 300
ctgacagtgc tgggatctag aggtggcgga ggatctggcg gcggaggaag cggaggcggc 360
ggatctcttg aaatggctga agtgcagctg gtgcagtctg gcgccgagat gaagaaacct 420
ggcgcctctc tgaagctgag ctgcaaggcc agcggctaca ccttcatcga ctactacgtg 480
tactggatgc ggcaggcccc tggacaggga ctcgaatcta tgggctggat caaccccaat 540
agcggcggca ccaattacgc ccagaaattc cagggcagag tgaccatgac cagagacacc 600
agcatcagca ccgcctacat ggaactgagc cggctgagat ccgacgacac cgccatgtac 660
tactgcgcca gatctcagcg cgacggctac atggattatt ggggccaggg aaccctggtc 720
accgtgtcca gc                                                     732

<210> 116
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 VH chain

<400> 116
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Met Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp Tyr
            20                  25                  30          
Tyr Val Tyr Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Ser Met
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Gln Arg Asp Gly Tyr Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 117
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 VH chain

<400> 117
gaagtgcagc tggtgcagtc tggggctgag atgaagaagc ctggggcctc actgaagctc 60
tcctgcaagg cttctggata caccttcatc gactactatg tatactggat gcgacaggcc 120
cctggacaag ggcttgagtc catgggatgg atcaacccta acagtggtgg cacaaactat 180
gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac 240
atggagctga gcaggctgag atctgacgac accgccatgt attactgtgc gcgctcccag 300
cgtgacggtt acatggatta ctggggtcaa ggtactctgg tgaccgtctc ctca       354

<210> 118
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 VH chain (nt) (O/SSE)

<400> 118
gaagtgcagc tggtgcagtc tggcgccgag atgaagaaac ctggcgcctc tctgaagctg 60
agctgcaagg ccagcggcta caccttcatc gactactacg tgtactggat gcggcaggcc 120
cctggacagg gactcgaatc tatgggctgg atcaacccca atagcggcgg caccaattac 180
gcccagaaat tccagggcag agtgaccatg accagagaca ccagcatcag caccgcctac 240
atggaactga gccggctgag atccgacgac accgccatgt actactgcgc cagatctcag 300
cgcgacggct acatggatta ttggggccag ggaaccctgg tcaccgtgtc cagc       354

<210> 119
<211> 105
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-55 VL chain

<400> 119
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln
 1               5                  10                  15      
Ser Ile Ala Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Trp Tyr
            20                  25                  30          
Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Asp Ser
        35                  40                  45              
Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly
    50                  55                  60                  
Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala
65                  70                  75                  80  
Asp Tyr Tyr Cys Ser Ser Asn Thr Arg Ser Ser Thr Leu Val Phe Gly
                85                  90                  95      
Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105 


<210> 120
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 VL chain

<400> 120
caatctgccc tgactcagcc tgcctccgtg tctgcgtctc ctggacagtc gatcgccatc 60
tcctgcactg gaaccagcag tgacgttggt tggtatcaac agcacccagg caaagccccc 120
aaactcatga tttatgagga cagtaagcgg ccctcagggg tttctaatcg cttctctggc 180
tccaagtctg gcaacacggc ctccctgacc atctctgggc tccaggctga ggacgaggct 240
gattattact gcagctcaaa tacaagaagc agcactttgg tgttcggcgg agggaccaag 300
ctgaccgtcc ta                                                     312

<210> 121
<211> 312
<212> DNA
<213> Artificial Sequence

<220> 
<223> BCMA-55 VL chain (nt) (O/SSE)

<400> 121
cagtctgccc tgacacagcc tgccagcgtt agtgctagtc ccggacagtc tatcgccatc 60
agctgtaccg gcaccagctc tgacgttggc tggtatcagc agcaccctgg caaggcccct 120
aagctgatga tctacgagga cagcaagagg cccagcggcg tgtccaatag attcagcggc 180
agcaagagcg gcaacaccgc cagcctgaca attagcggac tgcaggccga ggacgaggcc 240
gattactact gcagcagcaa cacccggtcc agcacactgg tttttggcgg aggcaccaag 300
ctgacagtgc tg                                                     312

<210> 122
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-55-scFv-mFc BCMA binding epitope 1

<400> 122
Met Leu Met Ala Gly
 1               5  


<210> 123
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-55-scFv-mFc BCMA binding epitope 2

<400> 123
Tyr Phe Asp Ser Leu Leu
 1               5      


<210> 124
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA-55-scFv-mFc BCMA binding epitope 3

<400> 124
Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu
 1               5                  10      


<210> 125
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C1 VH Chain

<400> 125
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe
    50                  55                  60                  
Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
            100                 105                 110         
Val Thr Val Ser Ser
        115         


<210> 126
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C1 VH-VL scFv

<400> 126
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met
        35                  40                  45              
Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe
    50                  55                  60                  
Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
            100                 105                 110         
Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala
    130                 135                 140                 
Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
145                 150                 155                 160 
Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro
                165                 170                 175     
Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr
            180                 185                 190         
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr
        195                 200                 205             
Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys
    210                 215                 220                 
Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu
225                 230                 235                 240 
Glu Ile Lys
            


<210> 127
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C1 VL Chain

<400> 127
Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly
 1               5                  10                  15      
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu
            20                  25                  30          
Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65                  70                  75                  80  
Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110     


<210> 128
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C1 VL-VH scFv

<400> 128
Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly
 1               5                  10                  15      
Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu
            20                  25                  30          
Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
        35                  40                  45              
Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp
65                  70                  75                  80  
Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg
                85                  90                  95      
Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile
        115                 120                 125             
Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr Val
    130                 135                 140                 
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Ser Ile
145                 150                 155                 160 
Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp
                165                 170                 175     
Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe Arg Gly
            180                 185                 190         
Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln
        195                 200                 205             
Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Leu
    210                 215                 220                 
Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr
225                 230                 235                 240 
Val Ser Ser
            


<210> 129
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C2  VH-VL scFv

<400> 129
Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
        35                  40                  45              
Ala Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser
    130                 135                 140                 
His Arg Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys
145                 150                 155                 160 
Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ser Trp Tyr Gln Gln Lys
                165                 170                 175     
Pro Gly Gln Ser Pro Lys Leu Leu Ile Phe Ser Ala Ser Tyr Arg Tyr
            180                 185                 190         
Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Ala Asp Phe
        195                 200                 205             
Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr
    210                 215                 220                 
Cys Gln Gln His Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys
225                 230                 235                 240 
Leu Asp Ile Lys
                


<210> 130
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C2  VL-VH scFv

<400> 130
Asp Val Val Met Thr Gln Ser His Arg Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys Gly Gly Gly Gly Ser
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Gln Leu Val Gln
        115                 120                 125             
Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu Thr Val Lys Leu Ser Cys
    130                 135                 140                 
Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Gly Met Asn Trp Val Lys
145                 150                 155                 160 
Gln Ala Pro Gly Lys Gly Phe Lys Trp Met Ala Trp Ile Asn Thr Tyr
                165                 170                 175     
Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe
            180                 185                 190         
Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr Leu Gln Ile Asn Asn Leu
        195                 200                 205             
Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Glu Ile Tyr
    210                 215                 220                 
Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
225                 230                 235                 240 
Thr Val Ser Ala
                


<210> 131
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C2 VH Chain

<400> 131
Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu
 1               5                  10                  15      
Thr Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met
        35                  40                  45              
Ala Trp Ile Asn Thr Tyr Thr Gly Glu Ser Tyr Phe Ala Asp Asp Phe
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Thr Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Thr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Glu Ile Tyr Tyr Gly Tyr Asp Gly Gly Phe Ala Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala
        115                 120         


<210> 132
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> BCMA-C2 VL Chain

<400> 132
Asp Val Val Met Thr Gln Ser His Arg Phe Met Ser Thr Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
            20                  25                  30          
Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45              
Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys
            100                 105         


<210> 133
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> BCMA epitope

<400> 133
Gln Asn Glu Tyr Phe Asp Ser Leu Leu
 1               5                  


<210> 134
<211> 39
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 ectodomain spacer

<400> 134
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro
        35                  


<210> 135
<211> 117
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28 ectodomain spacer

<400> 135
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc 60
catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc    117

<210> 136
<211> 41
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 endo

<400> 136
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      


<210> 137
<211> 123
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28 endo

<400> 137
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc 60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc 120
tcc                                                               123

<210> 138
<211> 28
<212> PRT
<213> Homo sapiens

<220> 
<223> CD28 transmembrane domain

<400> 138
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
 1               5                  10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25              


<210> 139
<211> 84
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28 transmembrane domain

<400> 139
atgttttggg tgctggtcgt ggtcggaggg gtgctggcct gttacagcct gctggtgaca 60
gtcgctttca tcatcttctg ggtg                                        84

<210> 140
<211> 84
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28 transmembrane domain

<400> 140
atgttctggg tgctcgtggt cgttggcgga gtgctggcct gttacagcct gctggttacc 60
gtggccttca tcatcttttg ggtc                                        84

<210> 141
<211> 41
<212> DNA
<213> Homo sapiens

<220> 
<223> CD28TM predicted splice acceptor site

<400> 141
aggggtgctg gcctgttaca gcctgctggt gacagtcgct t                     41

<210> 142
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD33 signal peptide

<400> 142
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala
 1               5                  10                  15      


<210> 143
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<223> CD3-zeta derived intracellular signaling domain

<400> 143
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 144
<211> 336
<212> DNA
<213> Homo sapiens

<220> 
<223> CD3-zeta derived intracellular signaling domain

<400> 144
agagtcaagt tttccaggtc cgccgacgct ccagcctacc agcaggggca gaaccagctg 60
tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc 120
cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac 180
gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg 240
aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc 300
tacgacgccc tgcacatgca ggccctgccc ccaagg                           336

<210> 145
<211> 336
<212> DNA
<213> Homo sapiens

<220> 
<223> CD3-zeta derived intracellular signaling domain

<400> 145
agagtgaagt tcagcagatc cgccgacgct ccagcctatc agcagggcca aaaccagctg 60
tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggataa gcggagaggc 120
agagatcctg aaatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat 180
gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc 240
agaagaggca agggacacga tggactgtac cagggcctga gcaccgccac caaggatacc 300
tatgacgcac tgcacatgca ggccctgcca cctaga                           336

<210> 146
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 alpha signal peptide

<400> 146
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala
        


<210> 147
<211> 183
<212> PRT
<213> Homo sapiens

<220> 
<223> Cynomolgus BCMA (GenBank No. EHH60172.1)

<400> 147
Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser
 1               5                  10                  15      
Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro
            20                  25                  30          
Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val
        35                  40                  45              
Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile
    50                  55                  60                  
Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser
65                  70                  75                  80  
Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu
                85                  90                  95      
Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile
            100                 105                 110         
Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu
        115                 120                 125             
Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro
    130                 135                 140                 
Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr
145                 150                 155                 160 
Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile
                165                 170                 175     
Glu Lys Ser Ile Ser Ala Arg
            180             


<210> 148
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A peptide

<400> 148
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser
 1               5                  10                  15      
Asn Pro Gly Pro
            20  


<210> 149
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> E2A peptide

<400> 149
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15      
Val Glu Ser Asn Pro Gly Pro
            20              


<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> EF1a/HTLV promoter forward primer

<400> 150
ctttttcgca acgggtttgc                                             20

<210> 151
<211> 544
<212> DNA
<213> Artificial Sequence

<220> 
<223> EF1alpha promoter with HTLV1 enhancer

<400> 151
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 60
agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa 120
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 180
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 240
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc 300
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg 360
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc 420
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac 480
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc 540
ctac                                                              544

<210> 152
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A peptide

<400> 152
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val
 1               5                  10                  15      
Glu Ser Asn Pro Gly Pro
            20          


<210> 153
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> F2A peptide

<400> 153
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15      
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25  


<210> 154
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> GMCSFR alpha chain signal peptide

<400> 154
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro
            20          


<210> 155
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> GMCSFR alpha chain signal peptide

<400> 155
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atccca                                                            66

<210> 156
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge-CH2-CH3 spacer

<400> 156
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 


<210> 157
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hinge-CH3 spacer

<400> 157
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115                 


<210> 158
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> human BCMA epitope (residues 17-27)

<400> 158
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg
 1               5                  10      


<210> 159
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> human BCMA epitope (residues 21-27)

<400> 159
Cys Ile Pro Cys Gln Leu Arg
 1               5          


<210> 160
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> human BCMA epitope (residues 30-39)

<400> 160
Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg
 1               5                  10  


<210> 161
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> human BCMA epitope (residues 44-50)

<400> 161
Ser Val Thr Asn Ser Val Lys
 1               5          


<210> 162
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> human BCMA epitope (residues 8-15)

<400> 162
Cys Ser Gln Asn Glu Tyr Phe
 1               5          


<210> 163
<211> 135
<212> PRT
<213> Homo sapiens

<220> 
<223> Human BCMA Variant (GenBank No. ABN42510.1)

<400> 163
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser
 1               5                  10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Arg Ser Gly Leu Leu
        35                  40                  45              
Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu Ile
    50                  55                  60                  
Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu
65                  70                  75                  80  
Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro
                85                  90                  95      
Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr
            100                 105                 110         
Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu Ile
        115                 120                 125             
Glu Lys Ser Ile Ser Ala Arg
    130                 135 


<210> 164
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> Human BCMA (GenBank No. BAB60895.1)

<400> 164
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser
 1               5                  10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser
        35                  40                  45              
Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu
    50                  55                  60                  
Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile
65                  70                  75                  80  
Ser Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu
                85                  90                  95      
Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu
            100                 105                 110         
Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys
        115                 120                 125             
Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe
    130                 135                 140                 
Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys
145                 150                 155                 160 
Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu
                165                 170                 175     
Ile Glu Lys Ser Ile Ser Ala Arg
            180                 


<210> 165
<211> 184
<212> PRT
<213> Homo sapiens

<220> 
<223> Human BCMA (NCBI No. NP_001183.2)

<400> 165
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser
 1               5                  10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser
        35                  40                  45              
Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu
    50                  55                  60                  
Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile
65                  70                  75                  80  
Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu
                85                  90                  95      
Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu
            100                 105                 110         
Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys
        115                 120                 125             
Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe
    130                 135                 140                 
Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys
145                 150                 155                 160 
Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu
                165                 170                 175     
Ile Glu Lys Ser Ile Ser Ala Arg
            180                 


<210> 166
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal peptide

<400> 166
Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser
 1               5                  10                  15      
Gly Ala Tyr Gly
            20  


<210> 167
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal sequence

<400> 167
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctccgg agcatacgga 60


<210> 168
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal sequence

<400> 168
atggtgctgc agacacaggt gttcatcagc ctgctgctgt ggatctccgg agcatacgga 60


<210> 169
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal sequence

<400> 169
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctacggc 60


<210> 170
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal sequence

<400> 170
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctctgg cgcctatgga 60


<210> 171
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<223> human IgG -kappa signal sequence

<400> 171
atggtgctgc agacacaggt gttcatctcc ctgctgctgt ggatctctgg agcatacgga 60


<210> 172
<211> 326
<212> PRT
<213> Homo sapiens

<220> 
<223> Human IgG2 Fc (Uniprot P01859)

<400> 172
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 173
<211> 327
<212> PRT
<213> Homo sapiens

<220> 
<223> Human IgG4 Fc (Uniprot P01861)

<400> 173
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 174
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified IgG4 hinge- IgG2/IgG4 CH2- IgG4 CH3
      spacer

<400> 174
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Leu Gly Lys
225             


<210> 175
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> Modified IgG4 hinge- IgG2/IgG4 CH2- IgG4 CH3
      spacer

<400> 175
gaatctaagt acggaccgcc ctgccctccc tgccctgctc ctcctgtggc tggaccaagc 60
gtgttcctgt ttccacctaa gcctaaagat accctgatga tttcccgcac acctgaagtg 120
acttgcgtgg tcgtggacgt gagccaggag gatccagaag tgcagttcaa ctggtacgtg 180
gacggcgtgg aagtccacaa tgctaagact aaaccccgag aggaacagtt tcagtcaact 240
taccgggtcg tgagcgtgct gaccgtcctg catcaggatt ggctgaacgg gaaggagtat 300
aagtgcaaag tgtctaataa gggactgcct agctccatcg agaaaacaat tagtaaggca 360
aaagggcagc ctcgagaacc acaggtgtat accctgcccc ctagccagga ggaaatgacc 420
aagaaccagg tgtccctgac atgtctggtc aaaggcttct atccaagtga catcgccgtg 480
gagtgggaat caaatgggca gcccgagaac aattacaaga ccacaccacc cgtgctggac 540
tctgatggaa gtttctttct gtattccagg ctgaccgtgg ataaatctcg ctggcaggag 600
ggcaacgtgt tctcttgcag tgtcatgcac gaagccctgc acaatcatta tacacagaag 660
tcactgagcc tgtccctggg caaa                                        684

<210> 176
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 176
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr
 1               5                  10                  15      
Lys Gly
        


<210> 177
<211> 399
<212> DNA
<213> Artificial Sequence

<220> 
<223> MND promoter

<400> 177
tttatttagt ctccagaaaa aggggggaat gaaagacccc acctgtaggt ttggcaagct 60
aggatcaagg ttaggaacag agagacagca gaatatgggc caaacaggat atctgtggta 120
agcagttcct gccccggctc agggccaaga acagttggaa cagcagaata tgggccaaac 180
aggatatctg tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggtccccag 240
atgcggtccc gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag 300
gacctgaaat gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc tcgcttctgt 360
tcgcgcgctt ctgctccccg agctcaataa aagagccca                        399

<210> 178
<211> 554
<212> DNA
<213> Artificial Sequence

<220> 
<223> modified EF1 alpha promoter

<400> 178
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg 60
agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa 120
actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt 180
atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac 240
agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc 300
gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg 360
cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc 420
cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac 480
tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc 540
ctacggctag cgcc                                                   554

<210> 179
<211> 185
<212> PRT
<213> Unknown

<220> 
<223> Mouse BCMA (NCBI No. NP_035738.1)

<400> 179
Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His
 1               5                  10                  15      
Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys
            20                  25                  30          
Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr
        35                  40                  45              
Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala
    50                  55                  60                  
Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu
65                  70                  75                  80  
Lys Asp Glu Pro Gln Ser Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu
                85                  90                  95      
Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg
            100                 105                 110         
Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu
        115                 120                 125             
Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro
    130                 135                 140                 
Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr
145                 150                 155                 160 
Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met
                165                 170                 175     
Gly Met Glu Lys Pro Thr His Thr Arg
            180                 185 


<210> 180
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 180
cagtttcttc ctgtatagta gactcaccgt ggataaatca a                     41

<210> 181
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 181
gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg c                     41

<210> 182
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 182
cggagtgctg gcctgttaca gcctgctggt taccgtggcc t                     41

<210> 183
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 183
gctgagagtg aagttcagca gatccgccga cgctccagcc t                     41

<210> 184
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 184
acacctccac tggatcccca agagctggat atcctgaaaa c                     41

<210> 185
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 185
accggattcc tcctgatcca agcctggcca gagaacagaa c                     41

<210> 186
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 186
acggccagtt tagcctggct gtggtgtctc tgaacatcac c                     41

<210> 187
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 187
aagtttcttt ctgtattcca gactgaccgt ggataaatct c                     41

<210> 188
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice acceptor site

<400> 188
cgccttgtcc tccttgtccc gctcctcctg ttgccggacc t                     41

<210> 189
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 189
agtctaaata cggac                                                  15

<210> 190
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 190
tcaactggta tgtgg                                                  15

<210> 191
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 191
accatctcca aggcc                                                  15

<210> 192
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 192
gccccaggtt tacac                                                  15

<210> 193
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 193
tcagcagatc cgccg                                                  15

<210> 194
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 194
ctcctgtgtg aactc                                                  15

<210> 195
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 195
tcggaaagtg tgcaa                                                  15

<210> 196
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 196
cagcacggcc agttt                                                  15

<210> 197
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 197
aaccggggcg agaac                                                  15

<210> 198
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site

<400> 198
ctggaaggcg agccc                                                  15

<210> 199
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Optimized splice donor site (last 4 nt outside of
      coding region)

<400> 199
tgttcatgtg agcgg                                                  15

<210> 200
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> optimized SSE modified IgG4 hinge- IgG2/IgG4 CH2-
      IgG4 CH3 spacer

<400> 200
gagtctaaat acggaccgcc ttgtcctcct tgtcccgctc ctcctgttgc cggaccttcc 60
gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg 120
acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ctggtatgtg 180
gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc 240
tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac 300
aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc 360
aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc 420
aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg 480
gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac 540
agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag 600
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa 660
agcctgagcc tgtctctggg caag                                        684

<210> 201
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A peptide

<400> 201
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn
 1               5                  10                  15      
Pro Gly Pro
            


<210> 202
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> P2A peptide

<400> 202
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15      
Glu Glu Asn Pro Gly Pro
            20          


<210> 203
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> predicted splice acceptor site

<400> 203
cgccttgtcc tccttgtcca gctcctcctg ttgccggacc t                     41

<210> 204
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> predicted splice acceptor site

<400> 204
cagtttcttc ctgtatagta gactcaccgt ggataaatca a                     41

<210> 205
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> predicted splice acceptor site

<400> 205
accggattcc tcctgattca ggcctggcca gagaacagaa c                     41

<210> 206
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 206
cgtctaggta agttt                                                  15

<210> 207
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 207
gaccaaggtg accgt                                                  15

<210> 208
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 208
tgcactggta ccagc                                                  15

<210> 209
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 209
taaactggta ccagc                                                  15

<210> 210
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 210
atctcctgta agggt                                                  15

<210> 211
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 211
ggtcaaggta ctctg                                                  15

<210> 212
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 212
gaggacagta agcgg                                                  15

<210> 213
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 213
ggtcaaggta ctctg                                                  15

<210> 214
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 214
tgcctccgtg tctgc                                                  15

<210> 215
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 215
caccaaggtg accgt                                                  15

<210> 216
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 216
tgaactggta tcagc                                                  15

<210> 217
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 217
atctcttgaa atggt                                                  15

<210> 218
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 218
ggccagggca cactg                                                  15

<210> 219
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 219
gaggacagca agagg                                                  15

<210> 220
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 220
ggccagggaa ccctg                                                  15

<210> 221
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 221
tgccagcgtt agtgc                                                  15

<210> 222
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 222
aatctaagta cggac                                                  15

<210> 223
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 223
tcaactggta cgtgg                                                  15

<210> 224
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 224
acaattagta aggca                                                  15

<210> 225
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 225
accacaggtg tatac                                                  15

<210> 226
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 226
tttccaggtc cgccg                                                  15

<210> 227
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 227
ctgctctgtg agtta                                                  15

<210> 228
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 228
acgcaaagtg tgtaa                                                  15

<210> 229
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 229
caacatggtc agttt                                                  15

<210> 230
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 230
aacagaggtg aaaac                                                  15

<210> 231
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Predicted splice donor site

<400> 231
ctggagggtg agcca                                                  15

<210> 232
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter predicted splice acceptor site

<400> 232
tggctccgcc tttttcccga gggtggggga gaaccgtata t                     41

<210> 233
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter predicted splice acceptor site

<400> 233
tgaactgcgt ccgccgtcta ggtaagttta aagctcaggt c                     41

<210> 234
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> promoter predicted splice acceptor site

<400> 234
ttctgttctg cgccgttaca gatccaagct gtgaccggcg c                     41

<210> 235
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer just 5' of WPRE

<400> 235
gatatcgaat tcctgcagcc                                             20

<210> 236
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> Spacer - codon optimized

<400> 236
gagtctaaat acggaccgcc ttgtcctcct tgtccagctc ctcctgttgc cggaccttcc 60
gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg 120
acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ttggtacgtg 180
gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc 240
tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac 300
aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc 360
aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc 420
aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg 480
gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac 540
agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag 600
ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa 660
agcctgagcc tgtctctggg caaa                                        684

<210> 237
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Spacer (IgG4hinge)

<400> 237
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 238
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Spacer (IgG4hinge)

<400> 238
gaatctaagt acggaccgcc ctgcccccct tgccct                           36

<210> 239
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> spacer predicted splice acceptor site

<400> 239
aagtttcttt ctgtattcca ggctgaccgt ggataaatct c                     41

<210> 240
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> spacer predicted splice acceptor site

<400> 240
gggcaacgtg ttctcttgca gtgtcatgca cgaagccctg c                     41

<210> 241
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 241
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
 1               5                  10                  15      
Gly Pro
        


<210> 242
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 242
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15      
Glu Asn Pro Gly Pro
            20      


<210> 243
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 243
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp
 1               5                  10                  15      
Val Glu Glu Asn Pro Gly Pro Arg
            20                  


<210> 244
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 244
ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat 60
cccggcccta gg                                                     72

<210> 245
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A peptide

<400> 245
cttgaaggtg gtggcgaagg cagaggcagc ctgcttacat gcggagatgt ggaagagaac 60
cccggaccta ga                                                     72

<210> 246
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> truncated EGFR (tEGFR) sequence

<400> 246
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         


<210> 247
<211> 1074
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated EGFR (tEGFR) sequence

<400> 247
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata 120
aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc 180
ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa 240
ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct 300
gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag 360
caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc 420
tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat 480
gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata 540
agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc 600
cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga 660
ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag 720
aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc 780
acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc 840
gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca 900
gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca 960
ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg 1020
ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga       1074

<210> 248
<211> 1074
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated EGFR (tEGFR) sequence (nt) (O/SSE)

<400> 248
atgctgctcc tcgtgacaag cctgctcctg tgtgaactcc ctcatccagc ttttctgctc 60
attcctcgga aagtgtgcaa cggcatcggc atcggagagt tcaaggacag cctgagcatc 120
aatgccacca acatcaagca cttcaagaat tgcaccagca tcagcggcga cctgcacatt 180
ctgcctgtgg cctttagagg cgacagcttc acccacacac ctccactgga tccccaagag 240
ctggatatcc tgaaaaccgt gaaagagatt accggattcc tcctgatcca agcctggcca 300
gagaacagaa ccgatctgca cgccttcgag aacctcgaga tcatcagagg ccggaccaaa 360
cagcacggcc agtttagcct ggctgtggtg tctctgaaca tcaccagtct gggcctgaga 420
agcctgaaag aaatctccga cggcgacgtg atcatctccg gaaacaagaa cctgtgctac 480
gccaacacca tcaactggaa gaagctgttc ggcacctccg gccagaaaac aaagatcatc 540
tctaaccggg gcgagaacag ctgcaaggcc accggacaag tttgtcacgc cctgtgtagc 600
cctgaaggct gttggggacc cgaacctaga gactgtgtgt cctgccggaa tgtgtcccgg 660
ggcagagaat gtgtggataa gtgcaacctg ctggaaggcg agccccgcga gtttgtggaa 720
aacagcgagt gcatccagtg tcaccccgag tgtctgcccc aggccatgaa cattacatgc 780
accggcagag gccccgacaa ctgtattcag tgcgcccact acatcgacgg ccctcactgc 840
gtgaaaacat gtccagctgg cgtgatggga gagaacaaca ccctcgtgtg gaagtatgcc 900
gacgccggac atgtgtgcca cctgtgtcac cctaattgca cctacggctg taccggacct 960
ggcctggaag gatgccctac aaacggccct aagatcccca gcattgccac cggaatggtt 1020
ggagccctgc tgcttctgtt ggtggtggcc ctcggaatcg gcctgttcat gtga       1074

<210> 249
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated marker predicted splice acceptor site

<400> 249
actcctcctc tggatccaca ggaactggat attctgaaaa c                     41

<210> 250
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated marker predicted splice acceptor site

<400> 250
acagggtttt tgctgattca ggcttggcct gaaaacagga c                     41

<210> 251
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated marker predicted splice acceptor site

<400> 251
atggtcagtt ttctcttgca gtcgtcagcc tgaacataac a                     41

<210> 252
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> truncated marker predicted splice donor site

<400> 252
tcttcatgtg agcgg                                                  15

<210> 253
<211> 589
<212> DNA
<213> Artificial Sequence

<220> 
<223> Woodchuck Hepatitis Virus (WHP)
      Posttranscriptional Regulatory Element (WPRE)

<400> 253
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct 60
ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt 120
atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg 180
tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact 240
ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct 300
attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg 360
ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc 420
gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc 480
aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt 540
cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc             589

<210> 254
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> predicted splice site

<400> 254
tcaattggta cgtgg                                                  15

<210> 255
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 255
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Leu Glu Met Ala
            20      


<210> 256
<211> 159
<212> PRT
<213> Streptomyces avidinii

<220> 
<223> Streptavidin (UniProt No. P22629)

<400> 256
Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly
 1               5                  10                  15      
Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr
            20                  25                  30          
Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser Ala Val Gly
        35                  40                  45              
Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro
    50                  55                  60                  
Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys
65                  70                  75                  80  
Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr
                85                  90                  95      
Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser
            100                 105                 110         
Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp
        115                 120                 125             
Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys
    130                 135                 140                 
Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln
145                 150                 155                 


<210> 257
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Minimal streptavidin

<400> 257
Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe
 1               5                  10                  15      
Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu Ser
            20                  25                  30          
Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp
        35                  40                  45              
Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val
    50                  55                  60                  
Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser
65                  70                  75                  80  
Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu
                85                  90                  95      
Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val
            100                 105                 110         
Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125     


<210> 258
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptavidin-binding peptide

<400> 258
His Pro Gln Phe
 1              


<210> 259
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptavidin Binding peptide

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa is selected from Gln, Asp, and Met

<400> 259
His Pro Xaa
 1          


<210> 260
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptavidin Binding peptide

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa is Trp, Lys or Arg

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa is any amino acid

<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa is Gly or Glu

<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa is Gly, Lys or Arg

<400> 260
Xaa Xaa His Pro Gln Phe Xaa Xaa
 1               5              


<210> 261
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptavidin Binding peptide

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa is any amino acid

<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa is Gly or Glu

<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa is Gly, Lys or Arg

<400> 261
Trp Xaa His Pro Gln Phe Xaa Xaa
 1               5              


<210> 262
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Streptavidin Binding peptide, Strep-tag

<400> 262
Trp Arg His Pro Gln Phe Gly Gly
 1               5              


<210> 263
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Strep-tag II

<400> 263
Trp Ser His Pro Gln Phe Glu Lys
 1               5              


<210> 264
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Sequential modules of streptavidin-binding peptide

<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa is any amino acid

<220> 
<221> REPEAT         
<222> (9)...(9)
<223> Xaa is repeated 8 or 12 times

<400> 264
Trp Ser His Pro Gln Phe Glu Lys Xaa Trp Ser His Pro Gln Phe Glu
 1               5                  10                  15      
Lys
    


<210> 265
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Sequential modules of streptavidin-binding peptide

<220> 
<221> REPEAT         
<222> (9)...(12)
<223> GlyGlyGlySer is repeated 2 or 3 times

<400> 265
Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Trp Ser His Pro
 1               5                  10                  15      
Gln Phe Glu Lys
            20  


<210> 266
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Twin-Strep-tag

<400> 266
Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      
Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys
            20                  25              


<210> 267
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Twin-Strep-tag

<400> 267
Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      
Trp Ser His Pro Gln Phe Glu Lys
            20                  


<210> 268
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Twin-Strep-tag

<400> 268
Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser
 1               5                  10                  15      
Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys
            20                  25              


<210> 269
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Twin-Strep-tag

<400> 269
Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys
            20                  25                  30  


<210> 270
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Twin-Strep-tag

<400> 270
Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Ser Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys
            20                  25                  30  


<210> 271
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400> 271
Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly
 1               5                  10                  15      
Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr
            20                  25                  30          
Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr Ala Arg Gly
        35                  40                  45              
Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro
    50                  55                  60                  
Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys
65                  70                  75                  80  
Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr
                85                  90                  95      
Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser
            100                 105                 110         
Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp
        115                 120                 125             
Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys
    130                 135                 140                 
Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln
145                 150                 155                 


<210> 272
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400> 272
Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe
 1               5                  10                  15      
Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr
            20                  25                  30          
Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp
        35                  40                  45              
Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val
    50                  55                  60                  
Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser
65                  70                  75                  80  
Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu
                85                  90                  95      
Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val
            100                 105                 110         
Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125     


<210> 273
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Val44-Thr45-Ala46-Arg47

<400> 273
Met Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr
 1               5                  10                  15      
Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val
            20                  25                  30          
Thr Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr
        35                  40                  45              
Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr
    50                  55                  60                  
Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp
65                  70                  75                  80  
Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp
                85                  90                  95      
Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu
            100                 105                 110         
Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125         


<210> 274
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400> 274
Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly
 1               5                  10                  15      
Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr
            20                  25                  30          
Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile Gly Ala Arg Gly
        35                  40                  45              
Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro
    50                  55                  60                  
Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys
65                  70                  75                  80  
Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr
                85                  90                  95      
Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser
            100                 105                 110         
Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val Gly His Asp
        115                 120                 125             
Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser Ile Asp Ala Ala Lys
    130                 135                 140                 
Lys Ala Gly Val Asn Asn Gly Asn Pro Leu Asp Ala Val Gln Gln
145                 150                 155                 


<210> 275
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400> 275
Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe
 1               5                  10                  15      
Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile Gly
            20                  25                  30          
Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp
        35                  40                  45              
Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val
    50                  55                  60                  
Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser
65                  70                  75                  80  
Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu
                85                  90                  95      
Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu Val
            100                 105                 110         
Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125     


<210> 276
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Ile44-Gly45-Ala-46-Arg47

<400> 276
Met Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr
 1               5                  10                  15      
Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Ile
            20                  25                  30          
Gly Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr
        35                  40                  45              
Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr
    50                  55                  60                  
Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp
65                  70                  75                  80  
Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp
                85                  90                  95      
Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu
            100                 105                 110         
Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125         


<210> 277
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Val44-Thr45-Ala46-Arg47 and
      Glu117, Gly120, Try121 (mutein m1-9)

<400> 277
Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe
 1               5                  10                  15      
Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr
            20                  25                  30          
Ala Arg Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp
        35                  40                  45              
Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val
    50                  55                  60                  
Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser
65                  70                  75                  80  
Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu
                85                  90                  95      
Leu Thr Ser Gly Thr Thr Glu Glu Asn Ala Gly Tyr Ser Thr Leu Val
            100                 105                 110         
Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125     


<210> 278
<211> 139
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mutein Streptavidin Val44-Thr45-Ala46-Arg47 and
      Glu117, Gly120, Try121 (mutein m1-9)

<400> 278
Asp Pro Ser Lys Asp Ser Lys Ala Gln Val Ser Ala Ala Glu Ala Gly
 1               5                  10                  15      
Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr Phe Ile Val Thr
            20                  25                  30          
Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Val Thr Ala Arg Gly
        35                  40                  45              
Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr Asp Ser Ala Pro
    50                  55                  60                  
Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr Val Ala Trp Lys
65                  70                  75                  80  
Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp Ser Gly Gln Tyr
                85                  90                  95      
Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp Leu Leu Thr Ser
            100                 105                 110         
Gly Thr Thr Glu Glu Asn Ala Gly Tyr Ser Thr Leu Val Gly His Asp
        115                 120                 125             
Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
    130                 135                 


<210> 279
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Minimal streptavidin

<400> 279
Met Glu Ala Gly Ile Thr Gly Thr Trp Tyr Asn Gln Leu Gly Ser Thr
 1               5                  10                  15      
Phe Ile Val Thr Ala Gly Ala Asp Gly Ala Leu Thr Gly Thr Tyr Glu
            20                  25                  30          
Ser Ala Val Gly Asn Ala Glu Ser Arg Tyr Val Leu Thr Gly Arg Tyr
        35                  40                  45              
Asp Ser Ala Pro Ala Thr Asp Gly Ser Gly Thr Ala Leu Gly Trp Thr
    50                  55                  60                  
Val Ala Trp Lys Asn Asn Tyr Arg Asn Ala His Ser Ala Thr Thr Trp
65                  70                  75                  80  
Ser Gly Gln Tyr Val Gly Gly Ala Glu Ala Arg Ile Asn Thr Gln Trp
                85                  90                  95      
Leu Leu Thr Ser Gly Thr Thr Glu Ala Asn Ala Trp Lys Ser Thr Leu
            100                 105                 110         
Val Gly His Asp Thr Phe Thr Lys Val Lys Pro Ser Ala Ala Ser
        115                 120                 125         


<210> 280
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variable Heavy chain of anti-CD3 antibody OKT3

<400> 280
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 281
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variable Light chain of anti-CD3 antibody OKT3

<400> 281
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr
        35                  40                  45              
Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr
                85                  90                  95      
Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
            100                 105     


<210> 282
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variable Heavy chain of anti-CD28 antibody CD28.3

<400> 282
Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Arg
 1               5                  10                  15      
Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Ile Ile His
            20                  25                  30          
Trp Ile Lys Leu Arg Ser Gly Gln Gly Leu Glu Trp Ile Gly Trp Phe
        35                  40                  45              
Tyr Pro Gly Ser Asn Asp Ile Gln Tyr Asn Ala Lys Phe Lys Gly Lys
    50                  55                  60                  
Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Glu Leu
65                  70                  75                  80  
Thr Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Arg
                85                  90                  95      
Asp Asp Phe Ser Gly Tyr Asp Ala Leu Pro Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val
        115     


<210> 283
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Variable Light chain of anti-CD28 antibody CD28.3

<400> 283
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Thr Asn Glu Asn Ile Tyr Ser Asn
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Thr His Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Leu Gln Ser
65                  70                  75                  80  
Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Cys
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             

