                         SEQUENCE LISTING

<110>  Tenaya Therapeutics, Inc.
 
<120>  GENE THERAPY VECTORS FOR TREATING HEART DISEASE

<130>  TENA-015/02WO 334682-2115

<150>  62/976,160
<151>  2020-02-13

<150>  63/047,633
<151>  2020-07-02

<160>  201   

<170>  PatentIn version 3.5

<210>  1
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  1
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      480

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      540

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      600


<210>  2
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  2
gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct       60

tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac      120

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      180

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      240

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      300

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      360

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      420

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      480

agactgagca gacgcctcca                                                  500


<210>  3
<211>  400
<212>  DNA
<213>  Homo sapiens

<400>  3
gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc       60

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      120

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      180

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      240

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      300

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      360

gcctcaccca gtccccgctg agactgagca gacgcctcca                            400


<210>  4
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  4
gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg       60

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      120

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      180

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      240

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      300


<210>  5
<211>  590
<212>  DNA
<213>  Homo sapiens

<400>  5
agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg cctaaggctg       60

ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt      120

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag      180

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      240

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      300

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      360

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      420

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      480

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      540

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 590


<210>  6
<211>  580
<212>  DNA
<213>  Homo sapiens

<400>  6
tgcagatgtc ctcactgggg ctggcagagc cggcaacctg cctaaggctg ctcagtccat       60

taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac      120

ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag      180

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      240

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      300

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      360

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      420

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      480

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      540

gcctcaccca gtccccgctg agactgagca gacgcctcca                            580


<210>  7
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  7
ctcactgggg ctggcagagc cggcaacctg cctaaggctg ctcagtccat taggagccag       60

tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg      120

ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct      180

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      240

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      300

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      360

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      420

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      480

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      540

gtccccgctg agactgagca gacgcctcca                                       570


<210>  8
<211>  560
<212>  DNA
<213>  Homo sapiens

<400>  8
ctggcagagc cggcaacctg cctaaggctg ctcagtccat taggagccag tagcctggaa       60

gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct      120

tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac      180

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      240

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      300

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      360

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      420

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      480

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      540

agactgagca gacgcctcca                                                  560


<210>  9
<211>  550
<212>  DNA
<213>  Homo sapiens

<400>  9
cggcaacctg cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta       60

cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc      120

tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca      180

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      240

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      300

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      360

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      420

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      480

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      540

gacgcctcca                                                             550


<210>  10
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  10
cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat       60

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      120

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      180

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      240

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      300

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      360

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      420

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      480

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      540


<210>  11
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  11
ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt       60

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag      120

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      180

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      240

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      300

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      360

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      420

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      480

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 530


<210>  12
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  12
taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac       60

ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag      120

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      180

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      240

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      300

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      360

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      420

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      480

gcctcaccca gtccccgctg agactgagca gacgcctcca                            520


<210>  13
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  13
tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg       60

ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct      120

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      180

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      240

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      300

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      360

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      420

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      480

gtccccgctg agactgagca gacgcctcca                                       510


<210>  14
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  14
cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc       60

tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca      120

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      180

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      240

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      300

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      360

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      420

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      480

gacgcctcca                                                             490


<210>  15
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  15
cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag       60

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      120

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      180

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      240

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      300

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      360

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      420

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      480


<210>  16
<211>  470
<212>  DNA
<213>  Homo sapiens

<400>  16
ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag       60

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      120

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      180

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      240

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      300

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      360

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      420

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 470


<210>  17
<211>  460
<212>  DNA
<213>  Homo sapiens

<400>  17
ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag       60

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      120

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      180

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      240

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      300

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      360

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      420

gcctcaccca gtccccgctg agactgagca gacgcctcca                            460


<210>  18
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  18
ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct       60

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      120

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      180

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      240

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      300

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      360

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      420

gtccccgctg agactgagca gacgcctcca                                       450


<210>  19
<211>  440
<212>  DNA
<213>  Homo sapiens

<400>  19
tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac       60

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      120

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      180

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      240

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      300

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      360

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      420

agactgagca gacgcctcca                                                  440


<210>  20
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  20
tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca       60

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      120

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      180

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      240

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      300

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      360

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      420

gacgcctcca                                                             430


<210>  21
<211>  420
<212>  DNA
<213>  Homo sapiens

<400>  21
acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc       60

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      120

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      180

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      240

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      300

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      360

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      420


<210>  22
<211>  410
<212>  DNA
<213>  Homo sapiens

<400>  22
tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg       60

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      120

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      180

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      240

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      300

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      360

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 410


<210>  23
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  23
gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat       60

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      120

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      180

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      240

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      300

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      360

gtccccgctg agactgagca gacgcctcca                                       390


<210>  24
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  24
cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc       60

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      120

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      180

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      240

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      300

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      360

agactgagca gacgcctcca                                                  380


<210>  25
<211>  370
<212>  DNA
<213>  Homo sapiens

<400>  25
gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca       60

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      120

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      180

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      240

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      300

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      360

gacgcctcca                                                             370


<210>  26
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  26
ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat       60

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      120

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      180

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      240

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      300

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      360


<210>  27
<211>  350
<212>  DNA
<213>  Homo sapiens

<400>  27
gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac       60

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      120

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      180

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      240

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      300

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 350


<210>  28
<211>  340
<212>  DNA
<213>  Homo sapiens

<400>  28
tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc       60

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      120

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      180

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      240

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      300

gcctcaccca gtccccgctg agactgagca gacgcctcca                            340


<210>  29
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  29
caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc       60

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      120

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      180

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      240

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      300

gtccccgctg agactgagca gacgcctcca                                       330


<210>  30
<211>  320
<212>  DNA
<213>  Homo sapiens

<400>  30
aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa       60

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      120

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      180

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      240

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      300

agactgagca gacgcctcca                                                  320


<210>  31
<211>  310
<212>  DNA
<213>  Homo sapiens

<400>  31
gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct       60

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      120

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      180

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      240

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      300

gacgcctcca                                                             310


<210>  32
<211>  290
<212>  DNA
<213>  Homo sapiens

<400>  32
tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat       60

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      120

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      180

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      240

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 290


<210>  33
<211>  280
<212>  DNA
<213>  Homo sapiens

<400>  33
atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat       60

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      120

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      180

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      240

gcctcaccca gtccccgctg agactgagca gacgcctcca                            280


<210>  34
<211>  270
<212>  DNA
<213>  Homo sapiens

<400>  34
tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt       60

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      120

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      180

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      240

gtccccgctg agactgagca gacgcctcca                                       270


<210>  35
<211>  260
<212>  DNA
<213>  Homo sapiens

<400>  35
tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct       60

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      120

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      180

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      240

agactgagca gacgcctcca                                                  260


<210>  36
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  36
gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt       60

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      120

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      180

catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca      240

gacgcctcca                                                             250


<210>  37
<211>  240
<212>  DNA
<213>  Homo sapiens

<400>  37
aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc       60

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      120

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      180

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      240


<210>  38
<211>  230
<212>  DNA
<213>  Homo sapiens

<400>  38
gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata       60

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      120

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      180

tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca                 230


<210>  39
<211>  220
<212>  DNA
<213>  Homo sapiens

<400>  39
ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca       60

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      120

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      180

gcctcaccca gtccccgctg agactgagca gacgcctcca                            220


<210>  40
<211>  210
<212>  DNA
<213>  Homo sapiens

<400>  40
acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc       60

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      120

gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca      180

gtccccgctg agactgagca gacgcctcca                                       210


<210>  41
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  41
gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat       60

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      120

ccccagccca catgcctgct taaagccctc tccatcctct gcctcaccca gtccccgctg      180

agactgagca gacgcctcca                                                  200


<210>  42
<211>  550
<212>  DNA
<213>  Homo sapiens

<400>  42
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      480

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      540

taaagccctc                                                             550


<210>  43
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  43
agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg cctaaggctg       60

ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt      120

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag      180

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      240

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      300

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      360

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      420

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      480

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      540


<210>  44
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  44
tgcagatgtc ctcactgggg ctggcagagc cggcaacctg cctaaggctg ctcagtccat       60

taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac      120

ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag      180

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      240

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      300

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      360

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      420

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      480

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 530


<210>  45
<211>  520
<212>  DNA
<213>  Homo sapiens

<400>  45
ctcactgggg ctggcagagc cggcaacctg cctaaggctg ctcagtccat taggagccag       60

tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg      120

ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct      180

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      240

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      300

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      360

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      420

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      480

gctcaccagg ccccagccca catgcctgct taaagccctc                            520


<210>  46
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  46
ctggcagagc cggcaacctg cctaaggctg ctcagtccat taggagccag tagcctggaa       60

gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct      120

tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac      180

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      240

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      300

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      360

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      420

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      480

ccccagccca catgcctgct taaagccctc                                       510


<210>  47
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  47
cggcaacctg cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta       60

cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc      120

tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca      180

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      240

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      300

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      360

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      420

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      480

catgcctgct taaagccctc                                                  500


<210>  48
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  48
cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat       60

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      120

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      180

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      240

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      300

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      360

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      420

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      480

taaagccctc                                                             490


<210>  49
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  49
ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt       60

ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag      120

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      180

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      240

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      300

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      360

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      420

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      480


<210>  50
<211>  470
<212>  DNA
<213>  Homo sapiens

<400>  50
taggagccag tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac       60

ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag      120

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      180

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      240

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      300

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      360

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      420

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 470


<210>  51
<211>  460
<212>  DNA
<213>  Homo sapiens

<400>  51
tagcctggaa gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg       60

ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct      120

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      180

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      240

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      300

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      360

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      420

gctcaccagg ccccagccca catgcctgct taaagccctc                            460


<210>  52
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  52
gatgtcttta cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct       60

tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac      120

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      180

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      240

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      300

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      360

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      420

ccccagccca catgcctgct taaagccctc                                       450


<210>  53
<211>  440
<212>  DNA
<213>  Homo sapiens

<400>  53
cccccagcat cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc       60

tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca      120

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      180

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      240

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      300

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      360

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      420

catgcctgct taaagccctc                                                  440


<210>  54
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  54
cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag       60

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      120

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      180

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      240

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      300

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      360

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      420

taaagccctc                                                             430


<210>  55
<211>  420
<212>  DNA
<213>  Homo sapiens

<400>  55
ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag       60

tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg      120

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      180

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      240

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      300

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      360

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      420


<210>  56
<211>  410
<212>  DNA
<213>  Homo sapiens

<400>  56
ataactcttg ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag       60

gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc      120

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      180

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      240

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      300

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      360

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 410


<210>  57
<211>  400
<212>  DNA
<213>  Homo sapiens

<400>  57
ccctctgcct tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct       60

gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat      120

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      180

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      240

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      300

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      360

gctcaccagg ccccagccca catgcctgct taaagccctc                            400


<210>  58
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  58
tccaagattc tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac       60

cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc      120

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      180

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      240

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      300

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      360

ccccagccca catgcctgct taaagccctc                                       390


<210>  59
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  59
tggtgctgag acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca       60

gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca      120

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      180

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      240

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      300

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      360

catgcctgct taaagccctc                                                  380


<210>  60
<211>  370
<212>  DNA
<213>  Homo sapiens

<400>  60
acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc       60

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      120

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      180

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      240

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      300

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      360

taaagccctc                                                             370


<210>  61
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  61
tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg       60

gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac      120

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      180

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      240

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      300

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      360


<210>  62
<211>  350
<212>  DNA
<213>  Homo sapiens

<400>  62
gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc       60

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      120

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      180

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      240

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      300

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 350


<210>  63
<211>  340
<212>  DNA
<213>  Homo sapiens

<400>  63
gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat       60

caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc      120

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      180

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      240

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      300

gctcaccagg ccccagccca catgcctgct taaagccctc                            340


<210>  64
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  64
cctgctccca gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc       60

aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa      120

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      180

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      240

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      300

ccccagccca catgcctgct taaagccctc                                       330


<210>  65
<211>  320
<212>  DNA
<213>  Homo sapiens

<400>  65
gctggccctc ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca       60

gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct      120

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      180

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      240

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      300

catgcctgct taaagccctc                                                  320


<210>  66
<211>  310
<212>  DNA
<213>  Homo sapiens

<400>  66
ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat       60

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      120

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      180

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      240

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      300

taaagccctc                                                             310


<210>  67
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  67
gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac       60

tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat      120

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      180

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      240

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      300


<210>  68
<211>  290
<212>  DNA
<213>  Homo sapiens

<400>  68
tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc       60

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      120

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      180

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      240

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 290


<210>  69
<211>  280
<212>  DNA
<213>  Homo sapiens

<400>  69
caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc       60

tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt      120

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      180

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      240

gctcaccagg ccccagccca catgcctgct taaagccctc                            280


<210>  70
<211>  270
<212>  DNA
<213>  Homo sapiens

<400>  70
aagagggaca gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa       60

tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct      120

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      180

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      240

ccccagccca catgcctgct taaagccctc                                       270


<210>  71
<211>  260
<212>  DNA
<213>  Homo sapiens

<400>  71
gctggtttat gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct       60

gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt      120

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      180

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      240

catgcctgct taaagccctc                                                  260


<210>  72
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  72
gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg       60

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      120

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      180

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      240

taaagccctc                                                             250


<210>  73
<211>  240
<212>  DNA
<213>  Homo sapiens

<400>  73
tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat       60

gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata      120

gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca      180

ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc      240


<210>  74
<211>  230
<212>  DNA
<213>  Homo sapiens

<400>  74
atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat       60

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      120

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      180

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc                 230


<210>  75
<211>  220
<212>  DNA
<213>  Homo sapiens

<400>  75
tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt       60

acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc      120

ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg      180

gctcaccagg ccccagccca catgcctgct taaagccctc                            220


<210>  76
<211>  210
<212>  DNA
<213>  Homo sapiens

<400>  76
tagcttatct gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct       60

gtagccttgt ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat      120

ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg      180

ccccagccca catgcctgct taaagccctc                                       210


<210>  77
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  77
gagcagctgg aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt       60

ccctggcacc tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc      120

cacccgtccc ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca      180

catgcctgct taaagccctc                                                  200


<210>  78
<211>  550
<212>  DNA
<213>  Homo sapiens

<400>  78
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      480

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      540

taaagccctc                                                             550


<210>  79
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  79
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      480

ctgtcgcaca ttcctccctc                                                  500


<210>  80
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  80
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc                                       450


<210>  81
<211>  400
<212>  DNA
<213>  Homo sapiens

<400>  81
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct                            400


<210>  82
<211>  350
<212>  DNA
<213>  Homo sapiens

<400>  82
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct                 350


<210>  83
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  83
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300


<210>  84
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  84
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg                                                             250


<210>  85
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  85
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag                                                  200


<210>  86
<211>  3825
<212>  DNA
<213>  Homo sapiens

<400>  86
atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa       60

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      120

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      180

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      240

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      300

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      360

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      420

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      480

ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg cgtggccggc      540

gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt ggacctgagc      600

agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag caaggtctat      660

ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta ccgctgtgag      720

gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca cgaggccatg      780

ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc tggaggtggt      840

cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc actgctgaaa      900

aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc agaggaggac      960

gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc cttccagtac     1020

ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg cgatgagaag     1080

aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa aggccacaag     1140

atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct caagaatggc     1200

caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc caagcgtacc     1260

ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt ggtgggtggc     1320

gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgctcatcac gcgccccttg     1380

gaggaccagc tggtgatggt ggggcagcgg gtggagtttg agtgtgaagt atcggaggag     1440

ggggcgcaag tcaaatggct gaaggacggg gtggagctga cccgggagga gaccttcaaa     1500

taccggttca agaaggacgg gcagagacac cacctgatca tcaacgaggc catgctggag     1560

gacgcggggc actatgcact gtgcactagc gggggccagg cgctggctga gctcattgtg     1620

caggaaaaga agctggaggt gtaccagagc atcgcagacc tgatggtggg cgcaaaggac     1680

caggcggtgt tcaaatgtga ggtctcagat gagaatgttc ggggtgtgtg gctgaagaat     1740

gggaaggagc tggtgcccga cagccgcata aaggtgtccc acatcgggcg ggtccacaaa     1800

ctgaccattg acgacgtcac acctgccgac gaggctgact acagctttgt gcccgagggc     1860

ttcgcctgca acctgtcagc caagctccac ttcatggagg tcaagattga cttcgtaccc     1920

aggcaggaac ctcccaagat ccacctggac tgcccaggcc gcataccaga caccattgtg     1980

gttgtagctg gaaataagct acgtctggac gtccctatct ctggggaccc cgctcccact     2040

gtgatctggc agaaggctat cacgcagggg aataaggccc cagccaggcc agccccagat     2100

gccccagagg acacaggtga cagcgatgag tgggtgtttg acaagaagct gctgtgtgag     2160

accgagggcc gggtccgcgt ggagaccacc aaggaccgca gcatcttcac ggtcgagggg     2220

gcagagaagg aagatgaggg cgtctacacg gtcacagtga agaaccctgt gggcgaggac     2280

caggtcaacc tcacagtcaa ggtcatcgac gtgccagacg cacctgcggc ccccaagatc     2340

agcaacgtgg gagaggactc ctgcacagta cagtgggagc cgcctgccta cgatggcggg     2400

cagcccatcc tgggctacat cctggagcgc aagaagaaga agagctaccg gtggatgcgg     2460

ctgaacttcg acctgattca ggagctgagt catgaagcgc ggcgcatgat cgagggcgtg     2520

gtgtacgaga tgcgcgtcta cgcggtcaac gccatcggca tgtccaggcc cagccctgcc     2580

tcccagccct tcatgcctat cggtcccccc agcgaaccca cccacctggc agtagaggac     2640

gtctctgaca ccacggtctc cctcaagtgg cggcccccag agcgcgtggg agcaggaggc     2700

ctggatggct acagcgtgga gtactgccca gagggctgct cagagtgggt ggctgccctg     2760

caggggctga cagagcacac atcgatactg gtgaaggacc tgcccacggg ggcccggctg     2820

cttttccgag tgcgggcaca caatatggca gggcctggag cccctgttac caccacggag     2880

ccggtgacag tgcaggagat cctgcaacgg ccacggcttc agctgcccag gcacctgcgc     2940

cagaccattc agaagaaggt cggggagcct gtgaaccttc tcatcccttt ccagggcaag     3000

ccccggcctc aggtgacctg gaccaaagag gggcagcccc tggcaggcga ggaggtgagc     3060

atccgcaaca gccccacaga caccatcctg ttcatccggg ccgctcgccg cgtgcattca     3120

ggcacttacc aggtgacggt gcgcattgag aacatggagg acaaggccac gctggtgctg     3180

caggttgttg acaagccaag tcctccccag gatctccggg tgactgacgc ctggggtctt     3240

aatgtggctc tggagtggaa gccaccccag gatgtcggca acacggaact ctgggggtac     3300

acagtgcaga aagccgacaa gaagaccatg gagtggttca ccgtcttgga gcattaccgc     3360

cgcacccact gcgtggtgcc agagctcatc attggcaatg gctactactt ccgcgtcttc     3420

agccagaata tggttggctt tagtgacaga gcggccacca ccaaggagcc cgtctttatc     3480

cccagaccag gcatcaccta tgagccaccc aactataagg ccctggactt ctccgaggcc     3540

ccaagcttca cccagcccct ggtgaaccgc tcggtcatcg cgggctacac tgctatgctc     3600

tgctgtgctg tccggggtag ccccaagccc aagatttcct ggttcaagaa tggcctggac     3660

ctgggagaag acgcccgctt ccgcatgttc agcaagcagg gagtgttgac tctggagatt     3720

agaaagccct gcccctttga cgggggcatc tatgtctgca gggccaccaa cttacagggc     3780

gaggcacggt gtgagtgccg cctggaggtg cgagtgcctc agtaa                     3825


<210>  87
<211>  3546
<212>  DNA
<213>  Homo sapiens

<400>  87
atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa       60

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      120

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      180

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      240

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      300

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      360

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      420

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      480

ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg cgtggccggc      540

gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt ggacctgagc      600

agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag caaggtctat      660

ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta ccgctgtgag      720

gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca cgaggccatg      780

ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc tggaggtggt      840

cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc actgctgaaa      900

aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc agaggaggac      960

gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc cttccagtac     1020

ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg cgatgagaag     1080

aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa aggccacaag     1140

atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct caagaatggc     1200

caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc caagcgtacc     1260

ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt ggtgggtggc     1320

gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgtaccagag catcgcagac     1380

ctgatggtgg gcgcaaagga ccaggcggtg ttcaaatgtg aggtctcaga tgagaatgtt     1440

cggggtgtgt ggctgaagaa tgggaaggag ctggtgcccg acagccgcat aaaggtgtcc     1500

cacatcgggc gggtccacaa actgaccatt gacgacgtca cacctgccga cgaggctgac     1560

tacagctttg tgcccgaggg cttcgcctgc aacctgtcag ccaagctcca cttcatggag     1620

gtcaagattg acttcgtacc caggcaggaa cctcccaaga tccacctgga ctgcccaggc     1680

cgcataccag acaccattgt ggttgtagct ggaaataagc tacgtctgga cgtccctatc     1740

tctggggacc ccgctcccac tgtgatctgg cagaaggcta tcacgcaggg gaataaggcc     1800

ccagccaggc cagccccaga tgccccagag gacacaggtg acagcgatga gtgggtgttt     1860

gacaagaagc tgctgtgtga gaccgagggc cgggtccgcg tggagaccac caaggaccgc     1920

agcatcttca cggtcgaggg ggcagagaag gaagatgagg gcgtctacac ggtcacagtg     1980

aagaaccctg tgggcgagga ccaggtcaac ctcacagtca aggtcatcga cgtgccagac     2040

gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag     2100

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag     2160

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg     2220

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc     2280

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc     2340

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca     2400

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc     2460

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac     2520

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga     2580

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tcctgcaacg gccacggctt     2640

cagctgccca ggcacctgcg ccagaccatt cagaagaagg tcggggagcc tgtgaacctt     2700

ctcatccctt tccagggcaa gccccggcct caggtgacct ggaccaaaga ggggcagccc     2760

ctggcaggcg aggaggtgag catccgcaac agccccacag acaccatcct gttcatccgg     2820

gccgctcgcc gcgtgcattc aggcacttac caggtgacgg tgcgcattga gaacatggag     2880

gacaaggcca cgctggtgct gcaggttgtt gacaagccaa gtcctcccca ggatctccgg     2940

gtgactgacg cctggggtct taatgtggct ctggagtgga agccacccca ggatgtcggc     3000

aacacggaac tctgggggta cacagtgcag aaagccgaca agaagaccat ggagtggttc     3060

accgtcttgg agcattaccg ccgcacccac tgcgtggtgc cagagctcat cattggcaat     3120

ggctactact tccgcgtctt cagccagaat atggttggct ttagtgacag agcggccacc     3180

accaaggagc ccgtctttat ccccagacca ggcatcacct atgagccacc caactataag     3240

gccctggact tctccgaggc cccaagcttc acccagcccc tggtgaaccg ctcggtcatc     3300

gcgggctaca ctgctatgct ctgctgtgct gtccggggta gccccaagcc caagatttcc     3360

tggttcaaga atggcctgga cctgggagaa gacgcccgct tccgcatgtt cagcaagcag     3420

ggagtgttga ctctggagat tagaaagccc tgcccctttg acgggggcat ctatgtctgc     3480

agggccacca acttacaggg cgaggcacgg tgtgagtgcc gcctggaggt gcgagtgcct     3540

cagtaa                                                                3546


<210>  88
<211>  3534
<212>  DNA
<213>  Homo sapiens

<400>  88
atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa       60

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      120

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      180

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      240

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      300

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      360

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      420

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      480

ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg cgtggccggc      540

gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt ggacctgagc      600

agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag caaggtctat      660

ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta ccgctgtgag      720

gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca cgaggccatg      780

ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc tggaggtggt      840

cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc actgctgaaa      900

aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc agaggaggac      960

gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc cttccagtac     1020

ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg cgatgagaag     1080

aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa aggccacaag     1140

atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct caagaatggc     1200

caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc caagcgtacc     1260

ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt ggtgggtggc     1320

gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgctcatcac gcgccccttg     1380

gaggaccagc tggtgatggt ggggcagcgg gtggagtttg agtgtgaagt atcggaggag     1440

ggggcgcaag tcaaatggct gaaggacggg gtggagctga cccgggagga gaccttcaaa     1500

taccggttca agaaggacgg gcagagacac cacctgatca tcaacgaggc catgctggag     1560

gacgcggggc actatgcact gtgcactagc gggggccagg cgctggctga gctcattgtg     1620

caggaaaaga agctggagcc tcccaagatc cacctggact gcccaggccg cataccagac     1680

accattgtgg ttgtagctgg aaataagcta cgtctggacg tccctatctc tggggacccc     1740

gctcccactg tgatctggca gaaggctatc acgcagggga ataaggcccc agccaggcca     1800

gccccagatg ccccagagga cacaggtgac agcgatgagt gggtgtttga caagaagctg     1860

ctgtgtgaga ccgagggccg ggtccgcgtg gagaccacca aggaccgcag catcttcacg     1920

gtcgaggggg cagagaagga agatgagggc gtctacacgg tcacagtgaa gaaccctgtg     1980

ggcgaggacc aggtcaacct cacagtcaag gtcatcgacg tgccagacgc acctgcggcc     2040

cccaagatca gcaacgtggg agaggactcc tgcacagtac agtgggagcc gcctgcctac     2100

gatggcgggc agcccatcct gggctacatc ctggagcgca agaagaagaa gagctaccgg     2160

tggatgcggc tgaacttcga cctgattcag gagctgagtc atgaagcgcg gcgcatgatc     2220

gagggcgtgg tgtacgagat gcgcgtctac gcggtcaacg ccatcggcat gtccaggccc     2280

agccctgcct cccagccctt catgcctatc ggtcccccca gcgaacccac ccacctggca     2340

gtagaggacg tctctgacac cacggtctcc ctcaagtggc ggcccccaga gcgcgtggga     2400

gcaggaggcc tggatggcta cagcgtggag tactgcccag agggctgctc agagtgggtg     2460

gctgccctgc aggggctgac agagcacaca tcgatactgg tgaaggacct gcccacgggg     2520

gcccggctgc ttttccgagt gcgggcacac aatatggcag ggcctggagc ccctgttacc     2580

accacggagc cggtgacagt gcaggagatc ctgcaacggc cacggcttca gctgcccagg     2640

cacctgcgcc agaccattca gaagaaggtc ggggagcctg tgaaccttct catccctttc     2700

cagggcaagc cccggcctca ggtgacctgg accaaagagg ggcagcccct ggcaggcgag     2760

gaggtgagca tccgcaacag ccccacagac accatcctgt tcatccgggc cgctcgccgc     2820

gtgcattcag gcacttacca ggtgacggtg cgcattgaga acatggagga caaggccacg     2880

ctggtgctgc aggttgttga caagccaagt cctccccagg atctccgggt gactgacgcc     2940

tggggtctta atgtggctct ggagtggaag ccaccccagg atgtcggcaa cacggaactc     3000

tgggggtaca cagtgcagaa agccgacaag aagaccatgg agtggttcac cgtcttggag     3060

cattaccgcc gcacccactg cgtggtgcca gagctcatca ttggcaatgg ctactacttc     3120

cgcgtcttca gccagaatat ggttggcttt agtgacagag cggccaccac caaggagccc     3180

gtctttatcc ccagaccagg catcacctat gagccaccca actataaggc cctggacttc     3240

tccgaggccc caagcttcac ccagcccctg gtgaaccgct cggtcatcgc gggctacact     3300

gctatgctct gctgtgctgt ccggggtagc cccaagccca agatttcctg gttcaagaat     3360

ggcctggacc tgggagaaga cgcccgcttc cgcatgttca gcaagcaggg agtgttgact     3420

ctggagatta gaaagccctg cccctttgac gggggcatct atgtctgcag ggccaccaac     3480

ttacagggcg aggcacggtg tgagtgccgc ctggaggtgc gagtgcctca gtaa           3534


<210>  89
<211>  3546
<212>  DNA
<213>  Homo sapiens

<400>  89
atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa       60

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      120

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      180

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      240

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      300

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      360

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      420

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      480

ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg cgtggccggc      540

gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt ggacctgagc      600

agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag caaggtctat      660

ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta ccgctgtgag      720

gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca cgaggccatg      780

ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc tggaggtggt      840

cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc actgctgaaa      900

aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc agaggaggac      960

gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc cttccagtac     1020

ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg cgatgagaag     1080

aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa aggccacaag     1140

atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct caagaatggc     1200

caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc caagcgtacc     1260

ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt ggtgggtggc     1320

gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgctcatcac gcgccccttg     1380

gaggaccagc tggtgatggt ggggcagcgg gtggagtttg agtgtgaagt atcggaggag     1440

ggggcgcaag tcaaatggct gaaggacggg gtggagctga cccgggagga gaccttcaaa     1500

taccggttca agaaggacgg gcagagacac cacctgatca tcaacgaggc catgctggag     1560

gacgcggggc actatgcact gtgcactagc gggggccagg cgctggctga gctcattgtg     1620

caggaaaaga agctggagcc caggcaggaa cctcccaaga tccacctgga ctgcccaggc     1680

cgcataccag acaccattgt ggttgtagct ggaaataagc tacgtctgga cgtccctatc     1740

tctggggacc ccgctcccac tgtgatctgg cagaaggcta tcacgcaggg gaataaggcc     1800

ccagccaggc cagccccaga tgccccagag gacacaggtg acagcgatga gtgggtgttt     1860

gacaagaagc tgctgtgtga gaccgagggc cgggtccgcg tggagaccac caaggaccgc     1920

agcatcttca cggtcgaggg ggcagagaag gaagatgagg gcgtctacac ggtcacagtg     1980

aagaaccctg tgggcgagga ccaggtcaac ctcacagtca aggtcatcga cgtgccagac     2040

gcacctgcgg cccccaagat cagcaacgtg ggagaggact cctgcacagt acagtgggag     2100

ccgcctgcct acgatggcgg gcagcccatc ctgggctaca tcctggagcg caagaagaag     2160

aagagctacc ggtggatgcg gctgaacttc gacctgattc aggagctgag tcatgaagcg     2220

cggcgcatga tcgagggcgt ggtgtacgag atgcgcgtct acgcggtcaa cgccatcggc     2280

atgtccaggc ccagccctgc ctcccagccc ttcatgccta tcggtccccc cagcgaaccc     2340

acccacctgg cagtagagga cgtctctgac accacggtct ccctcaagtg gcggccccca     2400

gagcgcgtgg gagcaggagg cctggatggc tacagcgtgg agtactgccc agagggctgc     2460

tcagagtggg tggctgccct gcaggggctg acagagcaca catcgatact ggtgaaggac     2520

ctgcccacgg gggcccggct gcttttccga gtgcgggcac acaatatggc agggcctgga     2580

gcccctgtta ccaccacgga gccggtgaca gtgcaggaga tcctgcaacg gccacggctt     2640

cagctgccca ggcacctgcg ccagaccatt cagaagaagg tcggggagcc tgtgaacctt     2700

ctcatccctt tccagggcaa gccccggcct caggtgacct ggaccaaaga ggggcagccc     2760

ctggcaggcg aggaggtgag catccgcaac agccccacag acaccatcct gttcatccgg     2820

gccgctcgcc gcgtgcattc aggcacttac caggtgacgg tgcgcattga gaacatggag     2880

gacaaggcca cgctggtgct gcaggttgtt gacaagccaa gtcctcccca ggatctccgg     2940

gtgactgacg cctggggtct taatgtggct ctggagtgga agccacccca ggatgtcggc     3000

aacacggaac tctgggggta cacagtgcag aaagccgaca agaagaccat ggagtggttc     3060

accgtcttgg agcattaccg ccgcacccac tgcgtggtgc cagagctcat cattggcaat     3120

ggctactact tccgcgtctt cagccagaat atggttggct ttagtgacag agcggccacc     3180

accaaggagc ccgtctttat ccccagacca ggcatcacct atgagccacc caactataag     3240

gccctggact tctccgaggc cccaagcttc acccagcccc tggtgaaccg ctcggtcatc     3300

gcgggctaca ctgctatgct ctgctgtgct gtccggggta gccccaagcc caagatttcc     3360

tggttcaaga atggcctgga cctgggagaa gacgcccgct tccgcatgtt cagcaagcag     3420

ggagtgttga ctctggagat tagaaagccc tgcccctttg acgggggcat ctatgtctgc     3480

agggccacca acttacaggg cgaggcacgg tgtgagtgcc gcctggaggt gcgagtgcct     3540

cagtaa                                                                3546


<210>  90
<211>  1156
<212>  DNA
<213>  Homo sapiens

<400>  90
agtccccgct gagactgagc agacgcctcc aggatctgtc ggcagctgct gttctgaggg       60

agagcagaga ccatgtctga catagaagag gtggtggaag agtacgagga ggaggagcag      120

gaagaagcag ctgttgaaga agaggaggac tggagagagg acgaagacga gcaggaggag      180

gcagcggaag aggatgctga agcagaggct gagaccgagg agaccagggc agaagaagat      240

gaagaagaag aggaagcaaa ggaggctgaa gatggcccaa tggaggagtc caaaccaaag      300

cccaggtcgt tcatgcccaa cttggtgcct cccaagatcc ccgatggaga gagagtggac      360

tttgatgaca tccaccggaa gcgcatggag aaggacctga atgagttgca ggcgctgatc      420

gaggctcact ttgagaacag gaagaaagag gaggaggagc tcgtttctct caaagacagg      480

atcgagagac gtcgggcaga gcgggccgag cagcagcgca tccggaatga gcgggagaag      540

gagcggcaga accgcctggc tgaagagagg gctcgacgag aggaggagga gaacaggagg      600

aaggctgagg atgaggcccg gaagaagaag gctttgtcca acatgatgca ttttgggggt      660

tacatccaga agacagagcg gaaaagtggg aagaggcaga ctgagcggga aaagaagaag      720

aagattctgg ctgagaggag gaaggtgctg gccattgacc acctgaatga agatcagctg      780

agggagaagg ccaaggagct gtggcagagc atctataact tggaggcaga gaagttcgac      840

ctgcaggaga agttcaagca gcagaaatat gagatcaatg ttctccgaaa caggatcaac      900

gataaccaga aagtctccaa gacccgcggg aaggctaaag tcaccgggcg ctggaaatag      960

agcctggcct ccttcaccaa agatctgctc ctcgctcgca cctgcctccg gcctgcactc     1020

ccccagttcc cgggccctcc tgggcacccc aggcagctcc tgtttggaaa tggggagctg     1080

gcctaggtgg gagccaccac tcctgcctgc ccccacaccc actccacacc agtaataaaa     1140

agccaccaca cactga                                                     1156


<210>  91
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 promoter

<400>  91
gttgccttct gccccccaac cctgctccca gctggccctc ccaggcctgg gttgctggcc       60

tctgctttat caggattctc aagagggaca gctggtttat gttgcatgac tgttccctgc      120

atatctgctc tggttttaaa tagcttatct gagcagctgg aggaccacat gggcttatat      180

ggcgtggggt acatgttcct gtagccttgt ccctggcacc tgccaaaata gcagccaaca      240

ccccccaccc ccaccgccat ccccctgccc cacccgtccc ctgtcgcaca ttcctccctc      300

cgcagggctg gctcaccagg ccccagccca catgcctgct taaagccctc tccatcctct      360

gcctcaccca gtccccgctg agactgagca gacgcctcca                            400


<210>  92
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 polyA signal

<400>  92
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  93
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 5' segment

<400>  93
tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct aggaagatcg       60

gaattcgccc ttaagttgcc ttctgccccc caaccctgct cccagctggc cctcccaggc      120

ctgggttgct ggcctctgct ttatcaggat tctcaagagg gacagctggt ttatgttgca      180

tgactgttcc ctgcatatct gctctggttt taaatagctt atctgagcag ctggaggacc      240

acatgggctt atatggcgtg gggtacatgt tcctgtagcc ttgtccctgg cacctgccaa      300

aatagcagcc aacacccccc acccccaccg ccatccccct gccccacccg tcccctgtcg      360

cacattcctc cctccgcagg gctggctcac caggccccag cccacatgcc tgcttaaagc      420

cctctccatc ctctgcctca cccagtcccc gctgagactg agcagacgcc tccagccacc      480


<210>  94
<211>  148
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 3' segment

<400>  94
agcttaataa aagatcttta ttttcattag atctgtgtgt tggttttttg tgtgctgggg       60

actcgagtta agggcgaatt cccgataagg atcttcctag agcatggcta cgtagataag      120

tagcatggcg ggttaatcat taactaca                                         148


<210>  95
<211>  4453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 with MYBPC3 no ITR

<400>  95
tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct aggaagatcg       60

gaattcgccc ttaagttgcc ttctgccccc caaccctgct cccagctggc cctcccaggc      120

ctgggttgct ggcctctgct ttatcaggat tctcaagagg gacagctggt ttatgttgca      180

tgactgttcc ctgcatatct gctctggttt taaatagctt atctgagcag ctggaggacc      240

acatgggctt atatggcgtg gggtacatgt tcctgtagcc ttgtccctgg cacctgccaa      300

aatagcagcc aacacccccc acccccaccg ccatccccct gccccacccg tcccctgtcg      360

cacattcctc cctccgcagg gctggctcac caggccccag cccacatgcc tgcttaaagc      420

cctctccatc ctctgcctca cccagtcccc gctgagactg agcagacgcc tccagccacc      480

atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg gtcagtggaa      540

gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg agtgaaggtg      600

cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct ggccacagag      660

ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg atcttacgca      720

gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc agagaaggca      780

gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc tggagaagcc      840

ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc aagctcagca      900

gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt cgtgatgcgg      960

ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg cgtggccggc     1020

gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt ggacctgagc     1080

agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag caaggtctat     1140

ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta ccgctgtgag     1200

gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca cgaggccatg     1260

ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc tggaggtggt     1320

cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc actgctgaaa     1380

aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc agaggaggac     1440

gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc cttccagtac     1500

ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg cgatgagaag     1560

aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa aggccacaag     1620

atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct caagaatggc     1680

caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc caagcgtacc     1740

ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt ggtgggtggc     1800

gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgctcatcac gcgccccttg     1860

gaggaccagc tggtgatggt ggggcagcgg gtggagtttg agtgtgaagt atcggaggag     1920

ggggcgcaag tcaaatggct gaaggacggg gtggagctga cccgggagga gaccttcaaa     1980

taccggttca agaaggacgg gcagagacac cacctgatca tcaacgaggc catgctggag     2040

gacgcggggc actatgcact gtgcactagc gggggccagg cgctggctga gctcattgtg     2100

caggaaaaga agctggaggt gtaccagagc atcgcagacc tgatggtggg cgcaaaggac     2160

caggcggtgt tcaaatgtga ggtctcagat gagaatgttc ggggtgtgtg gctgaagaat     2220

gggaaggagc tggtgcccga cagccgcata aaggtgtccc acatcgggcg ggtccacaaa     2280

ctgaccattg acgacgtcac acctgccgac gaggctgact acagctttgt gcccgagggc     2340

ttcgcctgca acctgtcagc caagctccac ttcatggagg tcaagattga cttcgtaccc     2400

aggcaggaac ctcccaagat ccacctggac tgcccaggcc gcataccaga caccattgtg     2460

gttgtagctg gaaataagct acgtctggac gtccctatct ctggggaccc cgctcccact     2520

gtgatctggc agaaggctat cacgcagggg aataaggccc cagccaggcc agccccagat     2580

gccccagagg acacaggtga cagcgatgag tgggtgtttg acaagaagct gctgtgtgag     2640

accgagggcc gggtccgcgt ggagaccacc aaggaccgca gcatcttcac ggtcgagggg     2700

gcagagaagg aagatgaggg cgtctacacg gtcacagtga agaaccctgt gggcgaggac     2760

caggtcaacc tcacagtcaa ggtcatcgac gtgccagacg cacctgcggc ccccaagatc     2820

agcaacgtgg gagaggactc ctgcacagta cagtgggagc cgcctgccta cgatggcggg     2880

cagcccatcc tgggctacat cctggagcgc aagaagaaga agagctaccg gtggatgcgg     2940

ctgaacttcg acctgattca ggagctgagt catgaagcgc ggcgcatgat cgagggcgtg     3000

gtgtacgaga tgcgcgtcta cgcggtcaac gccatcggca tgtccaggcc cagccctgcc     3060

tcccagccct tcatgcctat cggtcccccc agcgaaccca cccacctggc agtagaggac     3120

gtctctgaca ccacggtctc cctcaagtgg cggcccccag agcgcgtggg agcaggaggc     3180

ctggatggct acagcgtgga gtactgccca gagggctgct cagagtgggt ggctgccctg     3240

caggggctga cagagcacac atcgatactg gtgaaggacc tgcccacggg ggcccggctg     3300

cttttccgag tgcgggcaca caatatggca gggcctggag cccctgttac caccacggag     3360

ccggtgacag tgcaggagat cctgcaacgg ccacggcttc agctgcccag gcacctgcgc     3420

cagaccattc agaagaaggt cggggagcct gtgaaccttc tcatcccttt ccagggcaag     3480

ccccggcctc aggtgacctg gaccaaagag gggcagcccc tggcaggcga ggaggtgagc     3540

atccgcaaca gccccacaga caccatcctg ttcatccggg ccgctcgccg cgtgcattca     3600

ggcacttacc aggtgacggt gcgcattgag aacatggagg acaaggccac gctggtgctg     3660

caggttgttg acaagccaag tcctccccag gatctccggg tgactgacgc ctggggtctt     3720

aatgtggctc tggagtggaa gccaccccag gatgtcggca acacggaact ctgggggtac     3780

acagtgcaga aagccgacaa gaagaccatg gagtggttca ccgtcttgga gcattaccgc     3840

cgcacccact gcgtggtgcc agagctcatc attggcaatg gctactactt ccgcgtcttc     3900

agccagaata tggttggctt tagtgacaga gcggccacca ccaaggagcc cgtctttatc     3960

cccagaccag gcatcaccta tgagccaccc aactataagg ccctggactt ctccgaggcc     4020

ccaagcttca cccagcccct ggtgaaccgc tcggtcatcg cgggctacac tgctatgctc     4080

tgctgtgctg tccggggtag ccccaagccc aagatttcct ggttcaagaa tggcctggac     4140

ctgggagaag acgcccgctt ccgcatgttc agcaagcagg gagtgttgac tctggagatt     4200

agaaagccct gcccctttga cgggggcatc tatgtctgca gggccaccaa cttacagggc     4260

gaggcacggt gtgagtgccg cctggaggtg cgagtgcctc agtaaagctt aataaaagat     4320

ctttattttc attagatctg tgtgttggtt ttttgtgtgc tggggactcg agttaagggc     4380

gaattcccga taaggatctt cctagagcat ggctacgtag ataagtagca tggcgggtta     4440

atcattaact aca                                                        4453


<210>  96
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' ITR

<400>  96
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  97
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' ITR

<400>  97
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  98
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard0 viral genome

<400>  98
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagtcatg gagaagaccc accttgcaga tgtcctcact      240

ggggctggca gagccggcaa cctgcccaag gctgctcagt ccattaggag ccagtagcct      300

ggaagatgtc tttaccccca gcatcagttc aagtggagca gcacataact cttgccctct      360

gccttccaag attctggtgc tgagacttat ggagtgtctt ggaggttgcc ttctgccccc      420

caaccctgct cccagctggc cctcccaggc ctgggttgct ggcctctgct ttatcaggat      480

tctcaagagg gacagctggt ttatgttgca tgactgttcc ctgcatatct gctctggttt      540

taaatagctt atctgagcag ctggaggacc acatgggctt atatggcgtg gggtacatgt      600

tcctgtagcc ttgtccctgg cacctgccaa aatagcagcc aacacccccc acccccaccg      660

ccatccccct gccccacccg tcccctgtcg cacattcctc cctccgcagg gctggctcac      720

caggccccag cccacatgcc tgcttaaagc cctctccatc ctctgcctca cccagtcccc      780

gctgagactg agcagacgcc tccagccacc aagcttaata aaagatcttt attttcatta      840

gatctgtgtg ttggtttttt gtgtgctggg gactcgagtt aagggcgaat tcccgataag      900

gatcttccta gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa      960

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     1020

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     1080

agcgcgcag                                                             1089


<210>  99
<211>  830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard0 expression cassette

<400>  99
tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct aggaagatcg       60

gaattcgccc ttaagtcatg gagaagaccc accttgcaga tgtcctcact ggggctggca      120

gagccggcaa cctgcccaag gctgctcagt ccattaggag ccagtagcct ggaagatgtc      180

tttaccccca gcatcagttc aagtggagca gcacataact cttgccctct gccttccaag      240

attctggtgc tgagacttat ggagtgtctt ggaggttgcc ttctgccccc caaccctgct      300

cccagctggc cctcccaggc ctgggttgct ggcctctgct ttatcaggat tctcaagagg      360

gacagctggt ttatgttgca tgactgttcc ctgcatatct gctctggttt taaatagctt      420

atctgagcag ctggaggacc acatgggctt atatggcgtg gggtacatgt tcctgtagcc      480

ttgtccctgg cacctgccaa aatagcagcc aacacccccc acccccaccg ccatccccct      540

gccccacccg tcccctgtcg cacattcctc cctccgcagg gctggctcac caggccccag      600

cccacatgcc tgcttaaagc cctctccatc ctctgcctca cccagtcccc gctgagactg      660

agcagacgcc tccagccacc aagcttaata aaagatcttt attttcatta gatctgtgtg      720

ttggtttttt gtgtgctggg gactcgagtt aagggcgaat tcccgataag gatcttccta      780

gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa                 830


<210>  100
<211>  889
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 viral genome

<400>  100
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagttgcc ttctgccccc caaccctgct cccagctggc      240

cctcccaggc ctgggttgct ggcctctgct ttatcaggat tctcaagagg gacagctggt      300

ttatgttgca tgactgttcc ctgcatatct gctctggttt taaatagctt atctgagcag      360

ctggaggacc acatgggctt atatggcgtg gggtacatgt tcctgtagcc ttgtccctgg      420

cacctgccaa aatagcagcc aacacccccc acccccaccg ccatccccct gccccacccg      480

tcccctgtcg cacattcctc cctccgcagg gctggctcac caggccccag cccacatgcc      540

tgcttaaagc cctctccatc ctctgcctca cccagtcccc gctgagactg agcagacgcc      600

tccagccacc aagcttaata aaagatcttt attttcatta gatctgtgtg ttggtttttt      660

gtgtgctggg gactcgagtt aagggcgaat tcccgataag gatcttccta gagcatggct      720

acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt      780

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc      840

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                  889


<210>  101
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 expression cassette

<400>  101
tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct aggaagatcg       60

gaattcgccc ttaagttgcc ttctgccccc caaccctgct cccagctggc cctcccaggc      120

ctgggttgct ggcctctgct ttatcaggat tctcaagagg gacagctggt ttatgttgca      180

tgactgttcc ctgcatatct gctctggttt taaatagctt atctgagcag ctggaggacc      240

acatgggctt atatggcgtg gggtacatgt tcctgtagcc ttgtccctgg cacctgccaa      300

aatagcagcc aacacccccc acccccaccg ccatccccct gccccacccg tcccctgtcg      360

cacattcctc cctccgcagg gctggctcac caggccccag cccacatgcc tgcttaaagc      420

cctctccatc ctctgcctca cccagtcccc gctgagactg agcagacgcc tccagccacc      480

aagcttaata aaagatcttt attttcatta gatctgtgtg ttggtttttt gtgtgctggg      540

gactcgagtt aagggcgaat tcccgataag gatcttccta gagcatggct acgtagataa      600

gtagcatggc gggttaatca ttaactaca                                        629


<210>  102
<211>  4713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCard1 viral genome with MYBPC3

<400>  102
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagttgcc ttctgccccc caaccctgct cccagctggc      240

cctcccaggc ctgggttgct ggcctctgct ttatcaggat tctcaagagg gacagctggt      300

ttatgttgca tgactgttcc ctgcatatct gctctggttt taaatagctt atctgagcag      360

ctggaggacc acatgggctt atatggcgtg gggtacatgt tcctgtagcc ttgtccctgg      420

cacctgccaa aatagcagcc aacacccccc acccccaccg ccatccccct gccccacccg      480

tcccctgtcg cacattcctc cctccgcagg gctggctcac caggccccag cccacatgcc      540

tgcttaaagc cctctccatc ctctgcctca cccagtcccc gctgagactg agcagacgcc      600

tccagccacc atgcctgagc cggggaagaa gccagtctca gcttttagca agaagccacg      660

gtcagtggaa gtggccgcag gcagccctgc cgtgttcgag gccgagacag agcgggcagg      720

agtgaaggtg cgctggcagc gcggaggcag tgacatcagc gccagcaaca agtacggcct      780

ggccacagag ggcacacggc atacgctgac agtgcgggaa gtgggccctg ccgaccaggg      840

atcttacgca gtcattgctg gctcctccaa ggtcaagttc gacctcaagg tcatagaggc      900

agagaaggca gagcccatgc tggcccctgc ccctgcccct gctgaggcca ctggagcccc      960

tggagaagcc ccggccccag ccgctgagct gggagaaagt gccccaagtc ccaaagggtc     1020

aagctcagca gctctcaatg gtcctacccc tggagccccc gatgacccca ttggcctctt     1080

cgtgatgcgg ccacaggatg gcgaggtgac cgtgggtggc agcatcacct tctcagcccg     1140

cgtggccggc gccagcctcc tgaagccgcc tgtggtcaag tggttcaagg gcaaatgggt     1200

ggacctgagc agcaaggtgg gccagcacct gcagctgcac gacagctacg accgcgccag     1260

caaggtctat ctgttcgagc tgcacatcac cgatgcccag cctgccttca ctggcagcta     1320

ccgctgtgag gtgtccacca aggacaaatt tgactgctcc aacttcaatc tcactgtcca     1380

cgaggccatg ggcaccggag acctggacct cctatcagcc ttccgccgca cgagcctggc     1440

tggaggtggt cggcggatca gtgatagcca tgaggacact gggattctgg acttcagctc     1500

actgctgaaa aagagagaca gtttccggac cccgagggac tcgaagctgg aggcaccagc     1560

agaggaggac gtgtgggaga tcctacggca ggcaccccca tctgagtacg agcgcatcgc     1620

cttccagtac ggcgtcactg acctgcgcgg catgctaaag aggctcaagg gcatgaggcg     1680

cgatgagaag aagagcacag cctttcagaa gaagctggag ccggcctacc aggtgagcaa     1740

aggccacaag atccggctga ccgtggaact ggctgaccat gacgctgagg tcaaatggct     1800

caagaatggc caggagatcc agatgagcgg cagcaagtac atctttgagt ccatcggtgc     1860

caagcgtacc ctgaccatca gccagtgctc attggcggac gacgcagcct accagtgcgt     1920

ggtgggtggc gagaagtgta gcacggagct ctttgtgaaa gagccccctg tgctcatcac     1980

gcgccccttg gaggaccagc tggtgatggt ggggcagcgg gtggagtttg agtgtgaagt     2040

atcggaggag ggggcgcaag tcaaatggct gaaggacggg gtggagctga cccgggagga     2100

gaccttcaaa taccggttca agaaggacgg gcagagacac cacctgatca tcaacgaggc     2160

catgctggag gacgcggggc actatgcact gtgcactagc gggggccagg cgctggctga     2220

gctcattgtg caggaaaaga agctggaggt gtaccagagc atcgcagacc tgatggtggg     2280

cgcaaaggac caggcggtgt tcaaatgtga ggtctcagat gagaatgttc ggggtgtgtg     2340

gctgaagaat gggaaggagc tggtgcccga cagccgcata aaggtgtccc acatcgggcg     2400

ggtccacaaa ctgaccattg acgacgtcac acctgccgac gaggctgact acagctttgt     2460

gcccgagggc ttcgcctgca acctgtcagc caagctccac ttcatggagg tcaagattga     2520

cttcgtaccc aggcaggaac ctcccaagat ccacctggac tgcccaggcc gcataccaga     2580

caccattgtg gttgtagctg gaaataagct acgtctggac gtccctatct ctggggaccc     2640

cgctcccact gtgatctggc agaaggctat cacgcagggg aataaggccc cagccaggcc     2700

agccccagat gccccagagg acacaggtga cagcgatgag tgggtgtttg acaagaagct     2760

gctgtgtgag accgagggcc gggtccgcgt ggagaccacc aaggaccgca gcatcttcac     2820

ggtcgagggg gcagagaagg aagatgaggg cgtctacacg gtcacagtga agaaccctgt     2880

gggcgaggac caggtcaacc tcacagtcaa ggtcatcgac gtgccagacg cacctgcggc     2940

ccccaagatc agcaacgtgg gagaggactc ctgcacagta cagtgggagc cgcctgccta     3000

cgatggcggg cagcccatcc tgggctacat cctggagcgc aagaagaaga agagctaccg     3060

gtggatgcgg ctgaacttcg acctgattca ggagctgagt catgaagcgc ggcgcatgat     3120

cgagggcgtg gtgtacgaga tgcgcgtcta cgcggtcaac gccatcggca tgtccaggcc     3180

cagccctgcc tcccagccct tcatgcctat cggtcccccc agcgaaccca cccacctggc     3240

agtagaggac gtctctgaca ccacggtctc cctcaagtgg cggcccccag agcgcgtggg     3300

agcaggaggc ctggatggct acagcgtgga gtactgccca gagggctgct cagagtgggt     3360

ggctgccctg caggggctga cagagcacac atcgatactg gtgaaggacc tgcccacggg     3420

ggcccggctg cttttccgag tgcgggcaca caatatggca gggcctggag cccctgttac     3480

caccacggag ccggtgacag tgcaggagat cctgcaacgg ccacggcttc agctgcccag     3540

gcacctgcgc cagaccattc agaagaaggt cggggagcct gtgaaccttc tcatcccttt     3600

ccagggcaag ccccggcctc aggtgacctg gaccaaagag gggcagcccc tggcaggcga     3660

ggaggtgagc atccgcaaca gccccacaga caccatcctg ttcatccggg ccgctcgccg     3720

cgtgcattca ggcacttacc aggtgacggt gcgcattgag aacatggagg acaaggccac     3780

gctggtgctg caggttgttg acaagccaag tcctccccag gatctccggg tgactgacgc     3840

ctggggtctt aatgtggctc tggagtggaa gccaccccag gatgtcggca acacggaact     3900

ctgggggtac acagtgcaga aagccgacaa gaagaccatg gagtggttca ccgtcttgga     3960

gcattaccgc cgcacccact gcgtggtgcc agagctcatc attggcaatg gctactactt     4020

ccgcgtcttc agccagaata tggttggctt tagtgacaga gcggccacca ccaaggagcc     4080

cgtctttatc cccagaccag gcatcaccta tgagccaccc aactataagg ccctggactt     4140

ctccgaggcc ccaagcttca cccagcccct ggtgaaccgc tcggtcatcg cgggctacac     4200

tgctatgctc tgctgtgctg tccggggtag ccccaagccc aagatttcct ggttcaagaa     4260

tggcctggac ctgggagaag acgcccgctt ccgcatgttc agcaagcagg gagtgttgac     4320

tctggagatt agaaagccct gcccctttga cgggggcatc tatgtctgca gggccaccaa     4380

cttacagggc gaggcacggt gtgagtgccg cctggaggtg cgagtgcctc agtaaagctt     4440

aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtgc tggggactcg     4500

agttaagggc gaattcccga taaggatctt cctagagcat ggctacgtag ataagtagca     4560

tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct     4620

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     4680

ccgggcggcc tcagtgagcg agcgagcgcg cag                                  4713


<210>  103
<211>  1274
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly Ala Lys Asp 
545                 550                 555                 560 


Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val Arg Gly Val 
                565                 570                 575     


Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg Ile Lys Val 
            580                 585                 590         


Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp Val Thr Pro 
        595                 600                 605             


Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe Ala Cys Asn 
    610                 615                 620                 


Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp Phe Val Pro 
625                 630                 635                 640 


Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro 
                645                 650                 655     


Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro 
            660                 665                 670         


Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr 
        675                 680                 685             


Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp 
    690                 695                 700                 


Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu 
705                 710                 715                 720 


Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe 
                725                 730                 735     


Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr 
            740                 745                 750         


Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val 
        755                 760                 765             


Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly 
    770                 775                 780                 


Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly 
785                 790                 795                 800 


Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr 
                805                 810                 815     


Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu 
            820                 825                 830         


Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala 
        835                 840                 845             


Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe 
    850                 855                 860                 


Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp 
865                 870                 875                 880 


Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val 
                885                 890                 895     


Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly 
            900                 905                 910         


Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser 
        915                 920                 925             


Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val 
    930                 935                 940                 


Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu 
945                 950                 955                 960 


Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro 
                965                 970                 975     


Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn 
            980                 985                 990         


Leu Leu Ile Pro Phe Gln Gly Lys  Pro Arg Pro Gln Val  Thr Trp Thr 
        995                 1000                 1005             


Lys Glu  Gly Gln Pro Leu Ala  Gly Glu Glu Val Ser  Ile Arg Asn 
    1010                 1015                 1020             


Ser Pro  Thr Asp Thr Ile Leu  Phe Ile Arg Ala Ala  Arg Arg Val 
    1025                 1030                 1035             


His Ser  Gly Thr Tyr Gln Val  Thr Val Arg Ile Glu  Asn Met Glu 
    1040                 1045                 1050             


Asp Lys  Ala Thr Leu Val Leu  Gln Val Val Asp Lys  Pro Ser Pro 
    1055                 1060                 1065             


Pro Gln  Asp Leu Arg Val Thr  Asp Ala Trp Gly Leu  Asn Val Ala 
    1070                 1075                 1080             


Leu Glu  Trp Lys Pro Pro Gln  Asp Val Gly Asn Thr  Glu Leu Trp 
    1085                 1090                 1095             


Gly Tyr  Thr Val Gln Lys Ala  Asp Lys Lys Thr Met  Glu Trp Phe 
    1100                 1105                 1110             


Thr Val  Leu Glu His Tyr Arg  Arg Thr His Cys Val  Val Pro Glu 
    1115                 1120                 1125             


Leu Ile  Ile Gly Asn Gly Tyr  Tyr Phe Arg Val Phe  Ser Gln Asn 
    1130                 1135                 1140             


Met Val  Gly Phe Ser Asp Arg  Ala Ala Thr Thr Lys  Glu Pro Val 
    1145                 1150                 1155             


Phe Ile  Pro Arg Pro Gly Ile  Thr Tyr Glu Pro Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Ala Leu  Asp Phe Ser Glu Ala  Pro Ser Phe Thr Gln  Pro Leu Val 
    1175                 1180                 1185             


Asn Arg  Ser Val Ile Ala Gly  Tyr Thr Ala Met Leu  Cys Cys Ala 
    1190                 1195                 1200             


Val Arg  Gly Ser Pro Lys Pro  Lys Ile Ser Trp Phe  Lys Asn Gly 
    1205                 1210                 1215             


Leu Asp  Leu Gly Glu Asp Ala  Arg Phe Arg Met Phe  Ser Lys Gln 
    1220                 1225                 1230             


Gly Val  Leu Thr Leu Glu Ile  Arg Lys Pro Cys Pro  Phe Asp Gly 
    1235                 1240                 1245             


Gly Ile  Tyr Val Cys Arg Ala  Thr Asn Leu Gln Gly  Glu Ala Arg 
    1250                 1255                 1260             


Cys Glu  Cys Arg Leu Glu Val  Arg Val Pro Gln 
    1265                 1270                 


<210>  104
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Tyr Gln Ser Ile Ala Asp Leu Met Val Gly 
    450                 455                 460                 


Ala Lys Asp Gln Ala Val Phe Lys Cys Glu Val Ser Asp Glu Asn Val 
465                 470                 475                 480 


Arg Gly Val Trp Leu Lys Asn Gly Lys Glu Leu Val Pro Asp Ser Arg 
                485                 490                 495     


Ile Lys Val Ser His Ile Gly Arg Val His Lys Leu Thr Ile Asp Asp 
            500                 505                 510         


Val Thr Pro Ala Asp Glu Ala Asp Tyr Ser Phe Val Pro Glu Gly Phe 
        515                 520                 525             


Ala Cys Asn Leu Ser Ala Lys Leu His Phe Met Glu Val Lys Ile Asp 
    530                 535                 540                 


Phe Val Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly 
545                 550                 555                 560 


Arg Ile Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu 
                565                 570                 575     


Asp Val Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys 
            580                 585                 590         


Ala Ile Thr Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala 
        595                 600                 605             


Pro Glu Asp Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu 
    610                 615                 620                 


Leu Cys Glu Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg 
625                 630                 635                 640 


Ser Ile Phe Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr 
                645                 650                 655     


Thr Val Thr Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr 
            660                 665                 670         


Val Lys Val Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser 
        675                 680                 685             


Asn Val Gly Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr 
    690                 695                 700                 


Asp Gly Gly Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Ser Tyr Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu 
                725                 730                 735     


Ser His Glu Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg 
            740                 745                 750         


Val Tyr Ala Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser 
        755                 760                 765             


Gln Pro Phe Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala 
    770                 775                 780                 


Val Glu Asp Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro 
785                 790                 795                 800 


Glu Arg Val Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys 
                805                 810                 815     


Pro Glu Gly Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu 
            820                 825                 830         


His Thr Ser Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu 
        835                 840                 845             


Phe Arg Val Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr 
    850                 855                 860                 


Thr Thr Glu Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu 
865                 870                 875                 880 


Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu 
                885                 890                 895     


Pro Val Asn Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg Pro Gln Val 
            900                 905                 910         


Thr Trp Thr Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu Val Ser Ile 
        915                 920                 925             


Arg Asn Ser Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala Ala Arg Arg 
    930                 935                 940                 


Val His Ser Gly Thr Tyr Gln Val Thr Val Arg Ile Glu Asn Met Glu 
945                 950                 955                 960 


Asp Lys Ala Thr Leu Val Leu Gln Val Val Asp Lys Pro Ser Pro Pro 
                965                 970                 975     


Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val Ala Leu Glu 
            980                 985                 990         


Trp Lys Pro Pro Gln Asp Val Gly  Asn Thr Glu Leu Trp  Gly Tyr Thr 
        995                 1000                 1005             


Val Gln  Lys Ala Asp Lys Lys  Thr Met Glu Trp Phe  Thr Val Leu 
    1010                 1015                 1020             


Glu His  Tyr Arg Arg Thr His  Cys Val Val Pro Glu  Leu Ile Ile 
    1025                 1030                 1035             


Gly Asn  Gly Tyr Tyr Phe Arg  Val Phe Ser Gln Asn  Met Val Gly 
    1040                 1045                 1050             


Phe Ser  Asp Arg Ala Ala Thr  Thr Lys Glu Pro Val  Phe Ile Pro 
    1055                 1060                 1065             


Arg Pro  Gly Ile Thr Tyr Glu  Pro Pro Asn Tyr Lys  Ala Leu Asp 
    1070                 1075                 1080             


Phe Ser  Glu Ala Pro Ser Phe  Thr Gln Pro Leu Val  Asn Arg Ser 
    1085                 1090                 1095             


Val Ile  Ala Gly Tyr Thr Ala  Met Leu Cys Cys Ala  Val Arg Gly 
    1100                 1105                 1110             


Ser Pro  Lys Pro Lys Ile Ser  Trp Phe Lys Asn Gly  Leu Asp Leu 
    1115                 1120                 1125             


Gly Glu  Asp Ala Arg Phe Arg  Met Phe Ser Lys Gln  Gly Val Leu 
    1130                 1135                 1140             


Thr Leu  Glu Ile Arg Lys Pro  Cys Pro Phe Asp Gly  Gly Ile Tyr 
    1145                 1150                 1155             


Val Cys  Arg Ala Thr Asn Leu  Gln Gly Glu Ala Arg  Cys Glu Cys 
    1160                 1165                 1170             


Arg Leu  Glu Val Arg Val Pro  Gln 
    1175                 1180     


<210>  105
<211>  1177
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly Arg Ile Pro Asp 
545                 550                 555                 560 


Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu Asp Val Pro Ile 
                565                 570                 575     


Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys Ala Ile Thr Gln 
            580                 585                 590         


Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala Pro Glu Asp Thr 
        595                 600                 605             


Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu Leu Cys Glu Thr 
    610                 615                 620                 


Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg Ser Ile Phe Thr 
625                 630                 635                 640 


Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr Thr Val Thr Val 
                645                 650                 655     


Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr Val Lys Val Ile 
            660                 665                 670         


Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser Asn Val Gly Glu 
        675                 680                 685             


Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr Asp Gly Gly Gln 
    690                 695                 700                 


Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys Lys Ser Tyr Arg 
705                 710                 715                 720 


Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu Ser His Glu Ala 
                725                 730                 735     


Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg Val Tyr Ala Val 
            740                 745                 750         


Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser Gln Pro Phe Met 
        755                 760                 765             


Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala Val Glu Asp Val 
    770                 775                 780                 


Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro Glu Arg Val Gly 
785                 790                 795                 800 


Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys Pro Glu Gly Cys 
                805                 810                 815     


Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu His Thr Ser Ile 
            820                 825                 830         


Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu Phe Arg Val Arg 
        835                 840                 845             


Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr Thr Thr Glu Pro 
    850                 855                 860                 


Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu Gln Leu Pro Arg 
865                 870                 875                 880 


His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu Pro Val Asn Leu 
                885                 890                 895     


Leu Ile Pro Phe Gln Gly Lys Pro Arg Pro Gln Val Thr Trp Thr Lys 
            900                 905                 910         


Glu Gly Gln Pro Leu Ala Gly Glu Glu Val Ser Ile Arg Asn Ser Pro 
        915                 920                 925             


Thr Asp Thr Ile Leu Phe Ile Arg Ala Ala Arg Arg Val His Ser Gly 
    930                 935                 940                 


Thr Tyr Gln Val Thr Val Arg Ile Glu Asn Met Glu Asp Lys Ala Thr 
945                 950                 955                 960 


Leu Val Leu Gln Val Val Asp Lys Pro Ser Pro Pro Gln Asp Leu Arg 
                965                 970                 975     


Val Thr Asp Ala Trp Gly Leu Asn Val Ala Leu Glu Trp Lys Pro Pro 
            980                 985                 990         


Gln Asp Val Gly Asn Thr Glu Leu  Trp Gly Tyr Thr Val  Gln Lys Ala 
        995                 1000                 1005             


Asp Lys  Lys Thr Met Glu Trp  Phe Thr Val Leu Glu  His Tyr Arg 
    1010                 1015                 1020             


Arg Thr  His Cys Val Val Pro  Glu Leu Ile Ile Gly  Asn Gly Tyr 
    1025                 1030                 1035             


Tyr Phe  Arg Val Phe Ser Gln  Asn Met Val Gly Phe  Ser Asp Arg 
    1040                 1045                 1050             


Ala Ala  Thr Thr Lys Glu Pro  Val Phe Ile Pro Arg  Pro Gly Ile 
    1055                 1060                 1065             


Thr Tyr  Glu Pro Pro Asn Tyr  Lys Ala Leu Asp Phe  Ser Glu Ala 
    1070                 1075                 1080             


Pro Ser  Phe Thr Gln Pro Leu  Val Asn Arg Ser Val  Ile Ala Gly 
    1085                 1090                 1095             


Tyr Thr  Ala Met Leu Cys Cys  Ala Val Arg Gly Ser  Pro Lys Pro 
    1100                 1105                 1110             


Lys Ile  Ser Trp Phe Lys Asn  Gly Leu Asp Leu Gly  Glu Asp Ala 
    1115                 1120                 1125             


Arg Phe  Arg Met Phe Ser Lys  Gln Gly Val Leu Thr  Leu Glu Ile 
    1130                 1135                 1140             


Arg Lys  Pro Cys Pro Phe Asp  Gly Gly Ile Tyr Val  Cys Arg Ala 
    1145                 1150                 1155             


Thr Asn  Leu Gln Gly Glu Ala  Arg Cys Glu Cys Arg  Leu Glu Val 
    1160                 1165                 1170             


Arg Val  Pro Gln 
    1175         


<210>  106
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Pro Glu Pro Gly Lys Lys Pro Val Ser Ala Phe Ser Lys Lys Pro 
1               5                   10                  15      


Arg Ser Val Glu Val Ala Ala Gly Ser Pro Ala Val Phe Glu Ala Glu 
            20                  25                  30          


Thr Glu Arg Ala Gly Val Lys Val Arg Trp Gln Arg Gly Gly Ser Asp 
        35                  40                  45              


Ile Ser Ala Ser Asn Lys Tyr Gly Leu Ala Thr Glu Gly Thr Arg His 
    50                  55                  60                  


Thr Leu Thr Val Arg Glu Val Gly Pro Ala Asp Gln Gly Ser Tyr Ala 
65                  70                  75                  80  


Val Ile Ala Gly Ser Ser Lys Val Lys Phe Asp Leu Lys Val Ile Glu 
                85                  90                  95      


Ala Glu Lys Ala Glu Pro Met Leu Ala Pro Ala Pro Ala Pro Ala Glu 
            100                 105                 110         


Ala Thr Gly Ala Pro Gly Glu Ala Pro Ala Pro Ala Ala Glu Leu Gly 
        115                 120                 125             


Glu Ser Ala Pro Ser Pro Lys Gly Ser Ser Ser Ala Ala Leu Asn Gly 
    130                 135                 140                 


Pro Thr Pro Gly Ala Pro Asp Asp Pro Ile Gly Leu Phe Val Met Arg 
145                 150                 155                 160 


Pro Gln Asp Gly Glu Val Thr Val Gly Gly Ser Ile Thr Phe Ser Ala 
                165                 170                 175     


Arg Val Ala Gly Ala Ser Leu Leu Lys Pro Pro Val Val Lys Trp Phe 
            180                 185                 190         


Lys Gly Lys Trp Val Asp Leu Ser Ser Lys Val Gly Gln His Leu Gln 
        195                 200                 205             


Leu His Asp Ser Tyr Asp Arg Ala Ser Lys Val Tyr Leu Phe Glu Leu 
    210                 215                 220                 


His Ile Thr Asp Ala Gln Pro Ala Phe Thr Gly Ser Tyr Arg Cys Glu 
225                 230                 235                 240 


Val Ser Thr Lys Asp Lys Phe Asp Cys Ser Asn Phe Asn Leu Thr Val 
                245                 250                 255     


His Glu Ala Met Gly Thr Gly Asp Leu Asp Leu Leu Ser Ala Phe Arg 
            260                 265                 270         


Arg Thr Ser Leu Ala Gly Gly Gly Arg Arg Ile Ser Asp Ser His Glu 
        275                 280                 285             


Asp Thr Gly Ile Leu Asp Phe Ser Ser Leu Leu Lys Lys Arg Asp Ser 
    290                 295                 300                 


Phe Arg Thr Pro Arg Asp Ser Lys Leu Glu Ala Pro Ala Glu Glu Asp 
305                 310                 315                 320 


Val Trp Glu Ile Leu Arg Gln Ala Pro Pro Ser Glu Tyr Glu Arg Ile 
                325                 330                 335     


Ala Phe Gln Tyr Gly Val Thr Asp Leu Arg Gly Met Leu Lys Arg Leu 
            340                 345                 350         


Lys Gly Met Arg Arg Asp Glu Lys Lys Ser Thr Ala Phe Gln Lys Lys 
        355                 360                 365             


Leu Glu Pro Ala Tyr Gln Val Ser Lys Gly His Lys Ile Arg Leu Thr 
    370                 375                 380                 


Val Glu Leu Ala Asp His Asp Ala Glu Val Lys Trp Leu Lys Asn Gly 
385                 390                 395                 400 


Gln Glu Ile Gln Met Ser Gly Ser Lys Tyr Ile Phe Glu Ser Ile Gly 
                405                 410                 415     


Ala Lys Arg Thr Leu Thr Ile Ser Gln Cys Ser Leu Ala Asp Asp Ala 
            420                 425                 430         


Ala Tyr Gln Cys Val Val Gly Gly Glu Lys Cys Ser Thr Glu Leu Phe 
        435                 440                 445             


Val Lys Glu Pro Pro Val Leu Ile Thr Arg Pro Leu Glu Asp Gln Leu 
    450                 455                 460                 


Val Met Val Gly Gln Arg Val Glu Phe Glu Cys Glu Val Ser Glu Glu 
465                 470                 475                 480 


Gly Ala Gln Val Lys Trp Leu Lys Asp Gly Val Glu Leu Thr Arg Glu 
                485                 490                 495     


Glu Thr Phe Lys Tyr Arg Phe Lys Lys Asp Gly Gln Arg His His Leu 
            500                 505                 510         


Ile Ile Asn Glu Ala Met Leu Glu Asp Ala Gly His Tyr Ala Leu Cys 
        515                 520                 525             


Thr Ser Gly Gly Gln Ala Leu Ala Glu Leu Ile Val Gln Glu Lys Lys 
    530                 535                 540                 


Leu Glu Pro Arg Gln Glu Pro Pro Lys Ile His Leu Asp Cys Pro Gly 
545                 550                 555                 560 


Arg Ile Pro Asp Thr Ile Val Val Val Ala Gly Asn Lys Leu Arg Leu 
                565                 570                 575     


Asp Val Pro Ile Ser Gly Asp Pro Ala Pro Thr Val Ile Trp Gln Lys 
            580                 585                 590         


Ala Ile Thr Gln Gly Asn Lys Ala Pro Ala Arg Pro Ala Pro Asp Ala 
        595                 600                 605             


Pro Glu Asp Thr Gly Asp Ser Asp Glu Trp Val Phe Asp Lys Lys Leu 
    610                 615                 620                 


Leu Cys Glu Thr Glu Gly Arg Val Arg Val Glu Thr Thr Lys Asp Arg 
625                 630                 635                 640 


Ser Ile Phe Thr Val Glu Gly Ala Glu Lys Glu Asp Glu Gly Val Tyr 
                645                 650                 655     


Thr Val Thr Val Lys Asn Pro Val Gly Glu Asp Gln Val Asn Leu Thr 
            660                 665                 670         


Val Lys Val Ile Asp Val Pro Asp Ala Pro Ala Ala Pro Lys Ile Ser 
        675                 680                 685             


Asn Val Gly Glu Asp Ser Cys Thr Val Gln Trp Glu Pro Pro Ala Tyr 
    690                 695                 700                 


Asp Gly Gly Gln Pro Ile Leu Gly Tyr Ile Leu Glu Arg Lys Lys Lys 
705                 710                 715                 720 


Lys Ser Tyr Arg Trp Met Arg Leu Asn Phe Asp Leu Ile Gln Glu Leu 
                725                 730                 735     


Ser His Glu Ala Arg Arg Met Ile Glu Gly Val Val Tyr Glu Met Arg 
            740                 745                 750         


Val Tyr Ala Val Asn Ala Ile Gly Met Ser Arg Pro Ser Pro Ala Ser 
        755                 760                 765             


Gln Pro Phe Met Pro Ile Gly Pro Pro Ser Glu Pro Thr His Leu Ala 
    770                 775                 780                 


Val Glu Asp Val Ser Asp Thr Thr Val Ser Leu Lys Trp Arg Pro Pro 
785                 790                 795                 800 


Glu Arg Val Gly Ala Gly Gly Leu Asp Gly Tyr Ser Val Glu Tyr Cys 
                805                 810                 815     


Pro Glu Gly Cys Ser Glu Trp Val Ala Ala Leu Gln Gly Leu Thr Glu 
            820                 825                 830         


His Thr Ser Ile Leu Val Lys Asp Leu Pro Thr Gly Ala Arg Leu Leu 
        835                 840                 845             


Phe Arg Val Arg Ala His Asn Met Ala Gly Pro Gly Ala Pro Val Thr 
    850                 855                 860                 


Thr Thr Glu Pro Val Thr Val Gln Glu Ile Leu Gln Arg Pro Arg Leu 
865                 870                 875                 880 


Gln Leu Pro Arg His Leu Arg Gln Thr Ile Gln Lys Lys Val Gly Glu 
                885                 890                 895     


Pro Val Asn Leu Leu Ile Pro Phe Gln Gly Lys Pro Arg Pro Gln Val 
            900                 905                 910         


Thr Trp Thr Lys Glu Gly Gln Pro Leu Ala Gly Glu Glu Val Ser Ile 
        915                 920                 925             


Arg Asn Ser Pro Thr Asp Thr Ile Leu Phe Ile Arg Ala Ala Arg Arg 
    930                 935                 940                 


Val His Ser Gly Thr Tyr Gln Val Thr Val Arg Ile Glu Asn Met Glu 
945                 950                 955                 960 


Asp Lys Ala Thr Leu Val Leu Gln Val Val Asp Lys Pro Ser Pro Pro 
                965                 970                 975     


Gln Asp Leu Arg Val Thr Asp Ala Trp Gly Leu Asn Val Ala Leu Glu 
            980                 985                 990         


Trp Lys Pro Pro Gln Asp Val Gly  Asn Thr Glu Leu Trp  Gly Tyr Thr 
        995                 1000                 1005             


Val Gln  Lys Ala Asp Lys Lys  Thr Met Glu Trp Phe  Thr Val Leu 
    1010                 1015                 1020             


Glu His  Tyr Arg Arg Thr His  Cys Val Val Pro Glu  Leu Ile Ile 
    1025                 1030                 1035             


Gly Asn  Gly Tyr Tyr Phe Arg  Val Phe Ser Gln Asn  Met Val Gly 
    1040                 1045                 1050             


Phe Ser  Asp Arg Ala Ala Thr  Thr Lys Glu Pro Val  Phe Ile Pro 
    1055                 1060                 1065             


Arg Pro  Gly Ile Thr Tyr Glu  Pro Pro Asn Tyr Lys  Ala Leu Asp 
    1070                 1075                 1080             


Phe Ser  Glu Ala Pro Ser Phe  Thr Gln Pro Leu Val  Asn Arg Ser 
    1085                 1090                 1095             


Val Ile  Ala Gly Tyr Thr Ala  Met Leu Cys Cys Ala  Val Arg Gly 
    1100                 1105                 1110             


Ser Pro  Lys Pro Lys Ile Ser  Trp Phe Lys Asn Gly  Leu Asp Leu 
    1115                 1120                 1125             


Gly Glu  Asp Ala Arg Phe Arg  Met Phe Ser Lys Gln  Gly Val Leu 
    1130                 1135                 1140             


Thr Leu  Glu Ile Arg Lys Pro  Cys Pro Phe Asp Gly  Gly Ile Tyr 
    1145                 1150                 1155             


Val Cys  Arg Ala Thr Asn Leu  Gln Gly Glu Ala Arg  Cys Glu Cys 
    1160                 1165                 1170             


Arg Leu  Glu Val Arg Val Pro  Gln 
    1175                 1180     


<210>  107
<211>  3480
<212>  DNA
<213>  Homo sapiens

<400>  107
atgccggtgc ggaggggcca cgtcgcgccg cagaacacct tcctggacac catcatccgc       60

aagtttgagg gccagagccg taagttcatc atcgccaacg ctcgggtgga gaactgcgcc      120

gtcatctact gcaacgacgg cttctgcgag ctgtgcggct actcgcgggc cgaggtgatg      180

cagcgaccct gcacctgcga cttcctgcac gggccgcgca cgcagcgccg cgctgccgcg      240

cagatcgcgc aggcactgct gggcgccgag gagcgcaaag tggaaatcgc cttctaccgg      300

aaagatggga gctgcttcct atgtctggtg gatgtggtgc ccgtgaagaa cgaggatggg      360

gctgtcatca tgttcatcct caatttcgag gtggtgatgg agaaggacat ggtggggtcc      420

ccggctcatg acaccaacca ccggggcccc cccaccagct ggctggcccc aggccgcgcc      480

aagaccttcc gcctgaagct gcccgcgctg ctggcgctga cggcccggga gtcgtcggtg      540

cggtcgggcg gcgcgggcgg cgcgggcgcc ccgggggccg tggtggtgga cgtggacctg      600

acgcccgcgg cacccagcag cgagtcgctg gccctggacg aagtgacagc catggacaac      660

cacgtggcag ggctcgggcc cgcggaggag cggcgtgcgc tggtgggtcc cggctctccg      720

ccccgcagcg cgcccggcca gctcccatcg ccccgggcgc acagcctcaa ccccgacgcc      780

tcgggctcca gctgcagcct ggcccggacg cgctcccgag aaagctgcgc cagcgtgcgc      840

cgcgcctcgt cggccgacga catcgaggcc atgcgcgccg gggtgctgcc cccgccaccg      900

cgccacgcca gcaccggggc catgcaccca ctgcgcagcg gcttgctcaa ctccacctcg      960

gactccgacc tcgtgcgcta ccgcaccatt agcaagattc cccaaatcac cctcaacttt     1020

gtggacctca agggcgaccc cttcttggct tcgcccacca gtgaccgtga gatcatagca     1080

cctaagataa aggagcgaac ccacaatgtc actgagaagg tcacccaggt cctgtccctg     1140

ggcgccgacg tgctgcctga gtacaagctg caggcaccgc gcatccaccg ctggaccatc     1200

ctgcattaca gccccttcaa ggccgtgtgg gactggctca tcctgctgct ggtcatctac     1260

acggctgtct tcacacccta ctcggctgcc ttcctgctga aggagacgga agaaggcccg     1320

cctgctaccg agtgtggcta cgcctgccag ccgctggctg tggtggacct catcgtggac     1380

atcatgttca ttgtggacat cctcatcaac ttccgcacca cctacgtcaa tgccaacgag     1440

gaggtggtca gccaccccgg ccgcatcgcc gtccactact tcaagggctg gttcctcatc     1500

gacatggtgg ccgccatccc cttcgacctg ctcatcttcg gctctggctc tgaggagctg     1560

atcgggctgc tgaagactgc gcggctgctg cggctggtgc gcgtggcgcg gaagctggat     1620

cgctactcag agtacggcgc ggccgtgctg ttcttgctca tgtgcacctt tgcgctcatc     1680

gcgcactggc tagcctgcat ctggtacgcc atcggcaaca tggagcagcc acacatggac     1740

tcacgcatcg gctggctgca caacctgggc gaccagatag gcaaacccta caacagcagc     1800

ggcctgggcg gcccctccat caaggacaag tatgtgacgg cgctctactt caccttcagc     1860

agcctcacca gtgtgggctt cggcaacgtc tctcccaaca ccaactcaga gaagatcttc     1920

tccatctgcg tcatgctcat tggctccctc atgtatgcta gcatcttcgg caacgtgtcg     1980

gccatcatcc agcggctgta ctcgggcaca gcccgctacc acacacagat gctgcgggtg     2040

cgggagttca tccgcttcca ccagatcccc aatcccctgc gccagcgcct cgaggagtac     2100

ttccagcacg cctggtccta caccaacggc atcgacatga acgcggtgct gaagggcttc     2160

cctgagtgcc tgcaggctga catctgcctg cacctgaacc gctcactgct gcagcactgc     2220

aaacccttcc gaggggccac caagggctgc cttcgggccc tggccatgaa gttcaagacc     2280

acacatgcac cgccagggga cacactggtg catgctgggg acctgctcac cgccctgtac     2340

ttcatctccc ggggctccat cgagatcctg cggggcgacg tcgtcgtggc catcctgggg     2400

aagaatgaca tctttgggga gcctctgaac ctgtatgcaa ggcctggcaa gtcgaacggg     2460

gatgtgcggg ccctcaccta ctgtgaccta cacaagatcc atcgggacga cctgctggag     2520

gtgctggaca tgtaccctga gttctccgac cacttctggt ccagcctgga gatcaccttc     2580

aacctgcgag ataccaacat gatcccgggc tcccccggca gtacggagtt agagggtggc     2640

ttcagtcggc aacgcaagcg caagttgtcc ttccgcaggc gcacggacaa ggacacggag     2700

cagccagggg aggtgtcggc cttggggccg ggccgggcgg gggcagggcc gagtagccgg     2760

ggccggccgg gggggccgtg gggggagagc ccgtccagtg gcccctccag ccctgagagc     2820

agtgaggatg agggcccagg ccgcagctcc agccccctcc gcctggtgcc cttctccagc     2880

cccaggcccc ccggagagcc gccgggtggg gagcccctga tggaggactg cgagaagagc     2940

agcgacactt gcaaccccct gtcaggcgcc ttctcaggag tgtccaacat tttcagcttc     3000

tggggggaca gtcggggccg ccagtaccag gagctccctc gatgccccgc ccccaccccc     3060

agcctcctca acatccccct ctccagcccg ggtcggcggc cccggggcga cgtggagagc     3120

aggctggatg ccctccagcg ccagctcaac aggctggaga cccggctgag tgcagacatg     3180

gccactgtcc tgcagctgct acagaggcag atgacgctgg tcccgcccgc ctacagtgct     3240

gtgaccaccc cggggcctgg ccccacttcc acatccccgc tgttgcccgt cagccccctc     3300

cccaccctca ccttggactc gctttctcag gtttcccagt tcatggcgtg tgaggagctg     3360

cccccggggg ccccagagct tccccaagaa ggccccacac gacgcctctc cctaccgggc     3420

cagctggggg ccctcacctc ccagcccctg cacagacacg gctcggaccc gggcagttag     3480


<210>  108
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  109
<211>  3645
<212>  DNA
<213>  Homo sapiens

<400>  109
atggtggtgc cggagaagga gcagagctgg atccccaaga tcttcaagaa gaagacctgc       60

acgacgttca tagttgactc cacagatccg ggagggacct tgtgccagtg tgggcgcccc      120

cggaccgccc accccgcagt ggccatggag gatgccttcg gggcagccgt ggtgaccgtg      180

tgggacagcg atgcacacac cacggagaag cccaccgatg cctacggaga gctggacttc      240

acgggggccg gccgcaagca cagcaatttc ctccggctct ctgaccgaac ggatccagct      300

gcagtttata gtctggtcac acgcacatgg ggcttccgtg ccccgaacct ggtggtgtca      360

gtgctggggg gatcgggggg ccccgtcctc cagacctggc tgcaggacct gctgcgtcgt      420

gggctggtgc gggctgccca gagcacagga gcctggattg tcactggggg tctgcacacg      480

ggcatcggcc ggcatgttgg tgtggctgta cgggaccatc agatggccag cactgggggc      540

accaaggtgg tggccatggg tgtggccccc tggggtgtgg tccggaatag agacaccctc      600

atcaacccca agggctcgtt ccctgcgagg taccggtggc gcggtgaccc ggaggacggg      660

gtccagtttc ccctggacta caactactcg gccttcttcc tggtggacga cggcacacac      720

ggctgcctgg ggggcgagaa ccgcttccgc ttgcgcctgg agtcctacat ctcacagcag      780

aagacgggcg tgggagggac tggaattgac atccctgtcc tgctcctcct gattgatggt      840

gatgagaaga tgttgacgcg aatagagaac gccacccagg ctcagctccc atgtctcctc      900

gtggctggct cagggggagc tgcggactgc ctggcggaga ccctggaaga cactctggcc      960

ccagggagtg ggggagccag gcaaggcgaa gcccgagatc gaatcaggcg tttctttccc     1020

aaaggggacc ttgaggtcct gcaggcccag gtggagagga ttatgacccg gaaggagctc     1080

ctgacagtct attcttctga ggatgggtct gaggaattcg agaccatagt tttgaaggcc     1140

cttgtgaagg cctgtgggag ctcggaggcc tcagcctacc tggatgagct gcgtttggct     1200

gtggcttgga accgcgtgga cattgcccag agtgaactct ttcgggggga catccaatgg     1260

cggtccttcc atctcgaagc ttccctcatg gacgccctgc tgaatgaccg gcctgagttc     1320

gtgcgcttgc tcatttccca cggcctcagc ctgggccact tcctgacccc gatgcgcctg     1380

gcccaactct acagcgcggc gccctccaac tcgctcatcc gcaacctttt ggaccaggcg     1440

tcccacagcg caggcaccaa agccccagcc ctaaaagggg gagctgcgga gctccggccc     1500

cctgacgtgg ggcatgtgct gaggatgctg ctggggaaga tgtgcgcgcc gaggtacccc     1560

tccgggggcg cctgggaccc tcacccaggc cagggcttcg gggagagcat gtatctgctc     1620

tcggacaagg ccacctcgcc gctctcgctg gatgctggcc tcgggcaggc cccctggagc     1680

gacctgcttc tttgggcact gttgctgaac agggcacaga tggccatgta cttctgggag     1740

atgggttcca atgcagtttc ctcagctctt ggggcctgtt tgctgctccg ggtgatggca     1800

cgcctggagc ctgacgctga ggaggcagca cggaggaaag acctggcgtt caagtttgag     1860

gggatgggcg ttgacctctt tggcgagtgc tatcgcagca gtgaggtgag ggctgcccgc     1920

ctcctcctcc gtcgctgccc gctctggggg gatgccactt gcctccagct ggccatgcaa     1980

gctgacgccc gtgccttctt tgcccaggat ggggtacagt ctctgctgac acagaagtgg     2040

tggggagata tggccagcac tacacccatc tgggccctgg ttctcgcctt cttttgccct     2100

ccactcatct acacccgcct catcaccttc aggaaatcag aagaggagcc cacacgggag     2160

gagctagagt ttgacatgga tagtgtcatt aatggggaag ggcctgtcgg gacggcggac     2220

ccagccgaga agacgccgct gggggtcccg cgccagtcgg gccgtccggg ttgctgcggg     2280

ggccgctgcg gggggcgccg gtgcctacgc cgctggttcc acttctgggg cgcgccggtg     2340

accatcttca tgggcaacgt ggtcagctac ctgctgttcc tgctgctttt ctcgcgggtg     2400

ctgctcgtgg atttccagcc ggcgccgccc ggctccctgg agctgctgct ctatttctgg     2460

gctttcacgc tgctgtgcga ggaactgcgc cagggcctga gcggaggcgg gggcagcctc     2520

gccagcgggg gccccgggcc tggccatgcc tcactgagcc agcgcctgcg cctctacctc     2580

gccgacagct ggaaccagtg cgacctagtg gctctcacct gcttcctcct gggcgtgggc     2640

tgccggctga ccccgggttt gtaccacctg ggccgcactg tcctctgcat cgacttcatg     2700

gttttcacgg tgcggctgct tcacatcttc acggtcaaca aacagctggg gcccaagatc     2760

gtcatcgtga gcaagatgat gaaggacgtg ttcttcttcc tcttcttcct cggcgtgtgg     2820

ctggtagcct atggcgtggc cacggagggg ctcctgaggc cacgggacag tgacttccca     2880

agtatcctgc gccgcgtctt ctaccgtccc tacctgcaga tcttcgggca gattccccag     2940

gaggacatgg acgtggccct catggagcac agcaactgct cgtcggagcc cggcttctgg     3000

gcacaccctc ctggggccca ggcgggcacc tgcgtctccc agtatgccaa ctggctggtg     3060

gtgctgctcc tcgtcatctt cctgctcgtg gccaacatcc tgctggtcaa cttgctcatt     3120

gccatgttca gttacacatt cggcaaagta cagggcaaca gcgatctcta ctggaaggcg     3180

cagcgttacc gcctcatccg ggaattccac tctcggcccg cgctggcccc gccctttatc     3240

gtcatctccc acttgcgcct cctgctcagg caattgtgca ggcgaccccg gagcccccag     3300

ccgtcctccc cggccctcga gcatttccgg gtttaccttt ctaaggaagc cgagcggaag     3360

ctgctaacgt gggaatcggt gcataaggag aactttctgc tggcacgcgc tagggacaag     3420

cgggagagcg actccgagcg tctgaagcgc acgtcccaga aggtggactt ggcactgaaa     3480

cagctgggac acatccgcga gtacgaacag cgcctgaaag tgctggagcg ggaggtccag     3540

cagtgtagcc gcgtcctggg gtgggtggcc gaggccctga gccgctctgc cttgctgccc     3600

ccaggtgggc cgccaccccc tgacctgcct gggtccaaag actga                     3645


<210>  110
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Val Val Pro Glu Lys Glu Gln Ser Trp Ile Pro Lys Ile Phe Lys 
1               5                   10                  15      


Lys Lys Thr Cys Thr Thr Phe Ile Val Asp Ser Thr Asp Pro Gly Gly 
            20                  25                  30          


Thr Leu Cys Gln Cys Gly Arg Pro Arg Thr Ala His Pro Ala Val Ala 
        35                  40                  45              


Met Glu Asp Ala Phe Gly Ala Ala Val Val Thr Val Trp Asp Ser Asp 
    50                  55                  60                  


Ala His Thr Thr Glu Lys Pro Thr Asp Ala Tyr Gly Glu Leu Asp Phe 
65                  70                  75                  80  


Thr Gly Ala Gly Arg Lys His Ser Asn Phe Leu Arg Leu Ser Asp Arg 
                85                  90                  95      


Thr Asp Pro Ala Ala Val Tyr Ser Leu Val Thr Arg Thr Trp Gly Phe 
            100                 105                 110         


Arg Ala Pro Asn Leu Val Val Ser Val Leu Gly Gly Ser Gly Gly Pro 
        115                 120                 125             


Val Leu Gln Thr Trp Leu Gln Asp Leu Leu Arg Arg Gly Leu Val Arg 
    130                 135                 140                 


Ala Ala Gln Ser Thr Gly Ala Trp Ile Val Thr Gly Gly Leu His Thr 
145                 150                 155                 160 


Gly Ile Gly Arg His Val Gly Val Ala Val Arg Asp His Gln Met Ala 
                165                 170                 175     


Ser Thr Gly Gly Thr Lys Val Val Ala Met Gly Val Ala Pro Trp Gly 
            180                 185                 190         


Val Val Arg Asn Arg Asp Thr Leu Ile Asn Pro Lys Gly Ser Phe Pro 
        195                 200                 205             


Ala Arg Tyr Arg Trp Arg Gly Asp Pro Glu Asp Gly Val Gln Phe Pro 
    210                 215                 220                 


Leu Asp Tyr Asn Tyr Ser Ala Phe Phe Leu Val Asp Asp Gly Thr His 
225                 230                 235                 240 


Gly Cys Leu Gly Gly Glu Asn Arg Phe Arg Leu Arg Leu Glu Ser Tyr 
                245                 250                 255     


Ile Ser Gln Gln Lys Thr Gly Val Gly Gly Thr Gly Ile Asp Ile Pro 
            260                 265                 270         


Val Leu Leu Leu Leu Ile Asp Gly Asp Glu Lys Met Leu Thr Arg Ile 
        275                 280                 285             


Glu Asn Ala Thr Gln Ala Gln Leu Pro Cys Leu Leu Val Ala Gly Ser 
    290                 295                 300                 


Gly Gly Ala Ala Asp Cys Leu Ala Glu Thr Leu Glu Asp Thr Leu Ala 
305                 310                 315                 320 


Pro Gly Ser Gly Gly Ala Arg Gln Gly Glu Ala Arg Asp Arg Ile Arg 
                325                 330                 335     


Arg Phe Phe Pro Lys Gly Asp Leu Glu Val Leu Gln Ala Gln Val Glu 
            340                 345                 350         


Arg Ile Met Thr Arg Lys Glu Leu Leu Thr Val Tyr Ser Ser Glu Asp 
        355                 360                 365             


Gly Ser Glu Glu Phe Glu Thr Ile Val Leu Lys Ala Leu Val Lys Ala 
    370                 375                 380                 


Cys Gly Ser Ser Glu Ala Ser Ala Tyr Leu Asp Glu Leu Arg Leu Ala 
385                 390                 395                 400 


Val Ala Trp Asn Arg Val Asp Ile Ala Gln Ser Glu Leu Phe Arg Gly 
                405                 410                 415     


Asp Ile Gln Trp Arg Ser Phe His Leu Glu Ala Ser Leu Met Asp Ala 
            420                 425                 430         


Leu Leu Asn Asp Arg Pro Glu Phe Val Arg Leu Leu Ile Ser His Gly 
        435                 440                 445             


Leu Ser Leu Gly His Phe Leu Thr Pro Met Arg Leu Ala Gln Leu Tyr 
    450                 455                 460                 


Ser Ala Ala Pro Ser Asn Ser Leu Ile Arg Asn Leu Leu Asp Gln Ala 
465                 470                 475                 480 


Ser His Ser Ala Gly Thr Lys Ala Pro Ala Leu Lys Gly Gly Ala Ala 
                485                 490                 495     


Glu Leu Arg Pro Pro Asp Val Gly His Val Leu Arg Met Leu Leu Gly 
            500                 505                 510         


Lys Met Cys Ala Pro Arg Tyr Pro Ser Gly Gly Ala Trp Asp Pro His 
        515                 520                 525             


Pro Gly Gln Gly Phe Gly Glu Ser Met Tyr Leu Leu Ser Asp Lys Ala 
    530                 535                 540                 


Thr Ser Pro Leu Ser Leu Asp Ala Gly Leu Gly Gln Ala Pro Trp Ser 
545                 550                 555                 560 


Asp Leu Leu Leu Trp Ala Leu Leu Leu Asn Arg Ala Gln Met Ala Met 
                565                 570                 575     


Tyr Phe Trp Glu Met Gly Ser Asn Ala Val Ser Ser Ala Leu Gly Ala 
            580                 585                 590         


Cys Leu Leu Leu Arg Val Met Ala Arg Leu Glu Pro Asp Ala Glu Glu 
        595                 600                 605             


Ala Ala Arg Arg Lys Asp Leu Ala Phe Lys Phe Glu Gly Met Gly Val 
    610                 615                 620                 


Asp Leu Phe Gly Glu Cys Tyr Arg Ser Ser Glu Val Arg Ala Ala Arg 
625                 630                 635                 640 


Leu Leu Leu Arg Arg Cys Pro Leu Trp Gly Asp Ala Thr Cys Leu Gln 
                645                 650                 655     


Leu Ala Met Gln Ala Asp Ala Arg Ala Phe Phe Ala Gln Asp Gly Val 
            660                 665                 670         


Gln Ser Leu Leu Thr Gln Lys Trp Trp Gly Asp Met Ala Ser Thr Thr 
        675                 680                 685             


Pro Ile Trp Ala Leu Val Leu Ala Phe Phe Cys Pro Pro Leu Ile Tyr 
    690                 695                 700                 


Thr Arg Leu Ile Thr Phe Arg Lys Ser Glu Glu Glu Pro Thr Arg Glu 
705                 710                 715                 720 


Glu Leu Glu Phe Asp Met Asp Ser Val Ile Asn Gly Glu Gly Pro Val 
                725                 730                 735     


Gly Thr Ala Asp Pro Ala Glu Lys Thr Pro Leu Gly Val Pro Arg Gln 
            740                 745                 750         


Ser Gly Arg Pro Gly Cys Cys Gly Gly Arg Cys Gly Gly Arg Arg Cys 
        755                 760                 765             


Leu Arg Arg Trp Phe His Phe Trp Gly Ala Pro Val Thr Ile Phe Met 
    770                 775                 780                 


Gly Asn Val Val Ser Tyr Leu Leu Phe Leu Leu Leu Phe Ser Arg Val 
785                 790                 795                 800 


Leu Leu Val Asp Phe Gln Pro Ala Pro Pro Gly Ser Leu Glu Leu Leu 
                805                 810                 815     


Leu Tyr Phe Trp Ala Phe Thr Leu Leu Cys Glu Glu Leu Arg Gln Gly 
            820                 825                 830         


Leu Ser Gly Gly Gly Gly Ser Leu Ala Ser Gly Gly Pro Gly Pro Gly 
        835                 840                 845             


His Ala Ser Leu Ser Gln Arg Leu Arg Leu Tyr Leu Ala Asp Ser Trp 
    850                 855                 860                 


Asn Gln Cys Asp Leu Val Ala Leu Thr Cys Phe Leu Leu Gly Val Gly 
865                 870                 875                 880 


Cys Arg Leu Thr Pro Gly Leu Tyr His Leu Gly Arg Thr Val Leu Cys 
                885                 890                 895     


Ile Asp Phe Met Val Phe Thr Val Arg Leu Leu His Ile Phe Thr Val 
            900                 905                 910         


Asn Lys Gln Leu Gly Pro Lys Ile Val Ile Val Ser Lys Met Met Lys 
        915                 920                 925             


Asp Val Phe Phe Phe Leu Phe Phe Leu Gly Val Trp Leu Val Ala Tyr 
    930                 935                 940                 


Gly Val Ala Thr Glu Gly Leu Leu Arg Pro Arg Asp Ser Asp Phe Pro 
945                 950                 955                 960 


Ser Ile Leu Arg Arg Val Phe Tyr Arg Pro Tyr Leu Gln Ile Phe Gly 
                965                 970                 975     


Gln Ile Pro Gln Glu Asp Met Asp Val Ala Leu Met Glu His Ser Asn 
            980                 985                 990         


Cys Ser Ser Glu Pro Gly Phe Trp  Ala His Pro Pro Gly  Ala Gln Ala 
        995                 1000                 1005             


Gly Thr  Cys Val Ser Gln Tyr  Ala Asn Trp Leu Val  Val Leu Leu 
    1010                 1015                 1020             


Leu Val  Ile Phe Leu Leu Val  Ala Asn Ile Leu Leu  Val Asn Leu 
    1025                 1030                 1035             


Leu Ile  Ala Met Phe Ser Tyr  Thr Phe Gly Lys Val  Gln Gly Asn 
    1040                 1045                 1050             


Ser Asp  Leu Tyr Trp Lys Ala  Gln Arg Tyr Arg Leu  Ile Arg Glu 
    1055                 1060                 1065             


Phe His  Ser Arg Pro Ala Leu  Ala Pro Pro Phe Ile  Val Ile Ser 
    1070                 1075                 1080             


His Leu  Arg Leu Leu Leu Arg  Gln Leu Cys Arg Arg  Pro Arg Ser 
    1085                 1090                 1095             


Pro Gln  Pro Ser Ser Pro Ala  Leu Glu His Phe Arg  Val Tyr Leu 
    1100                 1105                 1110             


Ser Lys  Glu Ala Glu Arg Lys  Leu Leu Thr Trp Glu  Ser Val His 
    1115                 1120                 1125             


Lys Glu  Asn Phe Leu Leu Ala  Arg Ala Arg Asp Lys  Arg Glu Ser 
    1130                 1135                 1140             


Asp Ser  Glu Arg Leu Lys Arg  Thr Ser Gln Lys Val  Asp Leu Ala 
    1145                 1150                 1155             


Leu Lys  Gln Leu Gly His Ile  Arg Glu Tyr Glu Gln  Arg Leu Lys 
    1160                 1165                 1170             


Val Leu  Glu Arg Glu Val Gln  Gln Cys Ser Arg Val  Leu Gly Trp 
    1175                 1180                 1185             


Val Ala  Glu Ala Leu Ser Arg  Ser Ala Leu Leu Pro  Pro Gly Gly 
    1190                 1195                 1200             


Pro Pro  Pro Pro Asp Leu Pro  Gly Ser Lys Asp 
    1205                 1210                 


<210>  111
<211>  3357
<212>  DNA
<213>  Homo sapiens

<400>  111
atggcgcgga gcccgggacg cgcgtacgcc ctgctgcttc tcctgatctg ctttaacgtt       60

ggaagtggac ttcacttaca ggtcttaagc acaagaaatg aaaataagct gcttcctaaa      120

catcctcatt tagtgcggca aaagcgcgcc tggatcaccg cccccgtggc tcttcgggag      180

ggagaggatc tgtccaagaa gaatccaatt gccaagatac attctgatct tgcagaagaa      240

agaggactca aaattactta caaatacact ggaaaaggga ttacagagcc accttttggt      300

atatttgtct ttaacaaaga tactggagaa ctgaatgtta ccagcattct tgatcgagaa      360

gaaacaccat tttttctgct aacaggttac gctttggatg caagaggaaa caatgtagag      420

aaacccttag agctacgcat taaggttctt gatatcaatg acaacgaacc agtgttcaca      480

caggatgtct ttgttgggtc tgttgaagag ttgagtgcag cacatactct tgtgatgaaa      540

atcaatgcaa cagatgcaga tgagcccaat accctgaatt cgaaaatttc ctatagaatc      600

gtatctctgg agcctgctta tcctccagtg ttctacctaa ataaagatac aggagagatt      660

tatacaacca gtgttacctt ggacagagag gaacacagca gctacacttt gacagtagaa      720

gcaagagatg gcaatggaga agttacagac aaacctgtaa aacaagctca agttcagatt      780

cgtattttgg atgtcaatga caatatacct gtagtagaaa ataaagtgct tgaagggatg      840

gttgaagaaa atcaagtcaa cgtagaagtt acgcgcataa aagtgttcga tgcagatgaa      900

ataggttctg ataattggct ggcaaatttt acatttgcat caggaaatga aggaggttat      960

ttccacatag aaacagatgc tcaaactaac gaaggaattg tgacccttat taaggaagta     1020

gattatgaag aaatgaagaa tcttgacttc agtgttattg tcgctaataa agcagctttt     1080

cacaagtcga ttaggagtaa atacaagcct acacccattc ccatcaaggt caaagtgaaa     1140

aatgtgaaag aaggcattca ttttaaaagc agcgtcatct caatttatgt tagcgagagc     1200

atggatagat caagcaaagg ccaaataatt ggaaattttc aagcttttga tgaggacact     1260

ggactaccag cccatgcaag atatgtaaaa ttagaagata gagataattg gatctctgtg     1320

gattctgtca catctgaaat taaacttgca aaacttcctg attttgaatc tagatatgtt     1380

caaaatggca catacactgt aaagattgtg gccatatcag aagattatcc tagaaaaacc     1440

atcactggca cagtccttat caatgttgaa gacatcaacg acaactgtcc cacactgata     1500

gagcctgtgc agacaatctg tcacgatgca gagtatgtga atgttactgc agaggacctg     1560

gatggacacc caaacagtgg ccctttcagt ttctccgtca ttgacaaacc acctggcatg     1620

gcagaaaaat ggaaaatagc acgccaagaa agtaccagtg tgctgctgca acaaagtgag     1680

aaaaagcttg ggagaagtga aattcagttc ctgatttcag acaatcaggg ttttagttgt     1740

cctgaaaagc aggtccttac actcacagtt tgtgagtgtc tgcatggcag cggctgcagg     1800

gaagcacagc atgactccta tgtgggcctg ggacccgcag caattgcgct catgattttg     1860

gcctttctgc tcctgctatt ggtaccactt ttactgctga tgtgccattg cggaaagggc     1920

gccaaaggct ttacccccat acctggcacc atagagatgc tgcatccttg gaataatgaa     1980

ggagcaccac ctgaagacaa ggtggtgcca tcatttctgc cagtggatca agggggcagt     2040

ctagtaggaa gaaatggagt aggaggtatg gccaaggaag ccacgatgaa aggaagtagc     2100

tctgcttcca ttgtcaaagg gcaacatgag atgtccgaga tggatggaag gtgggaagaa     2160

cacagaagcc tgctttctgg tagagctacc cagtttacag gggccacagg cgctatcatg     2220

accactgaaa ccacgaagac cgcaagggcc acaggggctt ccagagacat ggccggagct     2280

caggcagctg ctgttgcact gaacgaagaa ttcttaagaa attatttcac tgataaagcg     2340

gcctcttaca ctgaggaaga tgaaaatcac acagccaaag attgccttct ggtttattct     2400

caggaagaaa ctgaatcgct gaatgcttct attggttgtt gcagttttat tgaaggagag     2460

ctagatgacc gcttcttaga tgatttggga cttaaattca agacactagc tgaagtttgc     2520

ctgggtcaaa aaatagatat aaataaggaa attgagcaga gacaaaaacc tgccacagaa     2580

acaagtatga acacagcttc acattcactc tgtgagcaaa ctatggttaa ttcagagaat     2640

acctactcct ctggcagtag cttcccagtt ccaaaatctt tgcaagaagc caatgcagag     2700

aaagtaactc aggaaatagt cactgaaaga tctgtgtctt ctaggcaggc gcaaaaggta     2760

gctacacctc ttcctgaccc aatggcttct agaaatgtga tagcaacaga aacttcctat     2820

gtcacagggt ccactatgcc accaaccact gtgatcctgg gtcctagcca gccacagagc     2880

cttattgtga cagagagggt gtatgctcca gcttctacct tggtagatca gccttatgct     2940

aatgaaggta cagttgtggt cactgaaaga gtaatacagc ctcatggggg tggatcgaat     3000

cctctggaag gcactcagca tcttcaagat gtaccttacg tcatggtgag ggaaagagag     3060

agcttccttg cccccagctc aggtgtgcag cctactctgg ccatgcctaa tatagcagta     3120

ggacagaatg tgacagtgac agaaagagtt ctagcacctg cttccactct gcaatccagt     3180

taccagattc ccactgaaaa ttctatgacg gctaggaaca ccacggtgtc tggagctgga     3240

gtccctggcc ctctgccaga ttttggttta gaggaatctg gtcattctaa ttctaccata     3300

accacatctt ccaccagagt taccaagcat agcactgtac agcattctta ctcctaa        3357


<210>  112
<211>  1118
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


<210>  113
<211>  2994
<212>  DNA
<213>  Homo sapiens

<400>  113
atggagaacg cgcacaccaa gacggtggag gaggtgctgg gccacttcgg cgtcaacgag       60

agtacggggc tgagcctgga acaggtcaag aagcttaagg agagatgggg ctccaacgag      120

ttaccggctg aagaaggaaa aaccttgctg gaacttgtga ttgagcagtt tgaagacttg      180

ctagttagga ttttattact ggcagcatgt atatcttttg ttttggcttg gtttgaagaa      240

ggtgaagaaa caattacagc ctttgtagaa ccttttgtaa ttttactcat attagtagcc      300

aatgcaattg tgggtgtatg gcaggaaaga aatgctgaaa atgccatcga agcccttaag      360

gaatatgagc ctgaaatggg caaagtgtat cgacaggaca gaaagagtgt gcagcggatt      420

aaagctaaag acatagttcc tggtgatatt gtagaaattg ctgttggtga caaagttcct      480

gctgatataa ggttaacttc catcaaatct accacactaa gagttgacca gtcaattctc      540

acaggtgaat ctgtctctgt catcaagcac actgatcccg tccctgaccc acgagctgtc      600

aaccaagata aaaagaacat gctgttttct ggtacaaaca ttgctgctgg gaaagctatg      660

ggagtggtgg tagcaactgg agttaacacc gaaattggca agatccggga tgaaatggtg      720

gcaacagaac aggagagaac accccttcag caaaaactag atgaatttgg ggaacagctt      780

tccaaagtca tctcccttat ttgcattgca gtctggatca taaatattgg gcacttcaat      840

gacccggttc atggagggtc ctggatcaga ggtgctattt actactttaa aattgcagtg      900

gccctggctg tagcagccat tcctgaaggt ctgcctgcag tcatcaccac ctgcctggct      960

cttggaactc gcagaatggc aaagaaaaat gccattgttc gaagcctccc gtctgtggaa     1020

acccttggtt gtacttctgt tatctgctca gacaagactg gtacacttac aacaaaccag     1080

atgtcagtct gcaggatgtt cattctggac agagtggaag gtgatacttg ttcccttaat     1140

gagtttacca taactggatc aacttatgca cctattggag aagtgcataa agatgataaa     1200

ccagtgaatt gtcaccagta tgatggtctg gtagaattag caacaatttg tgctctttgt     1260

aatgactctg ctttggatta caatgaggca aagggtgtgt atgaaaaagt tggagaagct     1320

acagagactg ctctcacttg cctagtagag aagatgaatg tatttgatac cgaattgaag     1380

ggtctttcta aaatagaacg tgcaaatgcc tgcaactcag tcattaaaca gctgatgaaa     1440

aaggaattca ctctagagtt ttcacgtgac agaaagtcaa tgtcggttta ctgtacacca     1500

aataaaccaa gcaggacatc aatgagcaag atgtttgtga agggtgctcc tgaaggtgtc     1560

attgacaggt gcacccacat tcgagttgga agtactaagg ttcctatgac ctctggagtc     1620

aaacagaaga tcatgtctgt cattcgagag tggggtagtg gcagcgacac actgcgatgc     1680

ctggccctgg ccactcatga caacccactg agaagagaag aaatgcacct tgaggactct     1740

gccaacttta ttaaatatga gaccaatctg accttcgttg gctgcgtggg catgctggat     1800

cctccgagaa tcgaggtggc ctcctccgtg aagctgtgcc ggcaagcagg catccgggtc     1860

atcatgatca ctggggacaa caagggcact gctgtggcca tctgtcgccg catcggcatc     1920

ttcgggcagg atgaggacgt gacgtcaaaa gctttcacag gccgggagtt tgatgaactc     1980

aacccctccg cccagcgaga cgcctgcctg aacgcccgct gttttgctcg agttgaaccc     2040

tcccacaagt ctaaaatcgt agaatttctt cagtcttttg atgagattac agctatgact     2100

ggcgatggcg tgaacgatgc tcctgctctg aagaaagccg agattggcat tgctatgggc     2160

tctggcactg cggtggctaa aaccgcctct gagatggtcc tggcggatga caacttctcc     2220

accattgtgg ctgccgttga ggaggggcgg gcaatctaca acaacatgaa acagttcatc     2280

cgctacctca tctcgtccaa cgtcggggaa gttgtctgta ttttcctgac agcagccctt     2340

ggatttcccg aggctttgat tcctgttcag ctgctctggg tcaatctggt gacagatggc     2400

ctgcctgcca ctgcactggg gttcaaccct cctgatctgg acatcatgaa taaacctccc     2460

cggaacccaa aggaaccatt gatcagcggg tggctctttt tccgttactt ggctattggc     2520

tgttacgtcg gcgctgctac cgtgggtgct gctgcatggt ggttcattgc tgctgacggt     2580

ggtccaagag tgtccttcta ccagctgagt catttcctac agtgtaaaga ggacaacccg     2640

gactttgaag gcgtggattg tgcaatcttt gaatccccat acccgatgac aatggcgctc     2700

tctgttctag taactataga aatgtgtaac gccctcaaca gcttgtccga aaaccagtcc     2760

ttgctgagga tgcccccctg ggagaacatc tggctcgtgg gctccatctg cctgtccatg     2820

tcactccact tcctgatcct ctatgtcgaa cccttgccac tcatcttcca gatcacaccg     2880

ctgaacgtga cccagtggct gatggtgctg aaaatctcct tgcccgtgat tctcatggat     2940

gagacgctca agtttgtggc ccgcaactac ctggaacctg caatactgga gtaa           2994


<210>  114
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Glu Asn Ala His Thr Lys Thr Val Glu Glu Val Leu Gly His Phe 
1               5                   10                  15      


Gly Val Asn Glu Ser Thr Gly Leu Ser Leu Glu Gln Val Lys Lys Leu 
            20                  25                  30          


Lys Glu Arg Trp Gly Ser Asn Glu Leu Pro Ala Glu Glu Gly Lys Thr 
        35                  40                  45              


Leu Leu Glu Leu Val Ile Glu Gln Phe Glu Asp Leu Leu Val Arg Ile 
    50                  55                  60                  


Leu Leu Leu Ala Ala Cys Ile Ser Phe Val Leu Ala Trp Phe Glu Glu 
65                  70                  75                  80  


Gly Glu Glu Thr Ile Thr Ala Phe Val Glu Pro Phe Val Ile Leu Leu 
                85                  90                  95      


Ile Leu Val Ala Asn Ala Ile Val Gly Val Trp Gln Glu Arg Asn Ala 
            100                 105                 110         


Glu Asn Ala Ile Glu Ala Leu Lys Glu Tyr Glu Pro Glu Met Gly Lys 
        115                 120                 125             


Val Tyr Arg Gln Asp Arg Lys Ser Val Gln Arg Ile Lys Ala Lys Asp 
    130                 135                 140                 


Ile Val Pro Gly Asp Ile Val Glu Ile Ala Val Gly Asp Lys Val Pro 
145                 150                 155                 160 


Ala Asp Ile Arg Leu Thr Ser Ile Lys Ser Thr Thr Leu Arg Val Asp 
                165                 170                 175     


Gln Ser Ile Leu Thr Gly Glu Ser Val Ser Val Ile Lys His Thr Asp 
            180                 185                 190         


Pro Val Pro Asp Pro Arg Ala Val Asn Gln Asp Lys Lys Asn Met Leu 
        195                 200                 205             


Phe Ser Gly Thr Asn Ile Ala Ala Gly Lys Ala Met Gly Val Val Val 
    210                 215                 220                 


Ala Thr Gly Val Asn Thr Glu Ile Gly Lys Ile Arg Asp Glu Met Val 
225                 230                 235                 240 


Ala Thr Glu Gln Glu Arg Thr Pro Leu Gln Gln Lys Leu Asp Glu Phe 
                245                 250                 255     


Gly Glu Gln Leu Ser Lys Val Ile Ser Leu Ile Cys Ile Ala Val Trp 
            260                 265                 270         


Ile Ile Asn Ile Gly His Phe Asn Asp Pro Val His Gly Gly Ser Trp 
        275                 280                 285             


Ile Arg Gly Ala Ile Tyr Tyr Phe Lys Ile Ala Val Ala Leu Ala Val 
    290                 295                 300                 


Ala Ala Ile Pro Glu Gly Leu Pro Ala Val Ile Thr Thr Cys Leu Ala 
305                 310                 315                 320 


Leu Gly Thr Arg Arg Met Ala Lys Lys Asn Ala Ile Val Arg Ser Leu 
                325                 330                 335     


Pro Ser Val Glu Thr Leu Gly Cys Thr Ser Val Ile Cys Ser Asp Lys 
            340                 345                 350         


Thr Gly Thr Leu Thr Thr Asn Gln Met Ser Val Cys Arg Met Phe Ile 
        355                 360                 365             


Leu Asp Arg Val Glu Gly Asp Thr Cys Ser Leu Asn Glu Phe Thr Ile 
    370                 375                 380                 


Thr Gly Ser Thr Tyr Ala Pro Ile Gly Glu Val His Lys Asp Asp Lys 
385                 390                 395                 400 


Pro Val Asn Cys His Gln Tyr Asp Gly Leu Val Glu Leu Ala Thr Ile 
                405                 410                 415     


Cys Ala Leu Cys Asn Asp Ser Ala Leu Asp Tyr Asn Glu Ala Lys Gly 
            420                 425                 430         


Val Tyr Glu Lys Val Gly Glu Ala Thr Glu Thr Ala Leu Thr Cys Leu 
        435                 440                 445             


Val Glu Lys Met Asn Val Phe Asp Thr Glu Leu Lys Gly Leu Ser Lys 
    450                 455                 460                 


Ile Glu Arg Ala Asn Ala Cys Asn Ser Val Ile Lys Gln Leu Met Lys 
465                 470                 475                 480 


Lys Glu Phe Thr Leu Glu Phe Ser Arg Asp Arg Lys Ser Met Ser Val 
                485                 490                 495     


Tyr Cys Thr Pro Asn Lys Pro Ser Arg Thr Ser Met Ser Lys Met Phe 
            500                 505                 510         


Val Lys Gly Ala Pro Glu Gly Val Ile Asp Arg Cys Thr His Ile Arg 
        515                 520                 525             


Val Gly Ser Thr Lys Val Pro Met Thr Ser Gly Val Lys Gln Lys Ile 
    530                 535                 540                 


Met Ser Val Ile Arg Glu Trp Gly Ser Gly Ser Asp Thr Leu Arg Cys 
545                 550                 555                 560 


Leu Ala Leu Ala Thr His Asp Asn Pro Leu Arg Arg Glu Glu Met His 
                565                 570                 575     


Leu Glu Asp Ser Ala Asn Phe Ile Lys Tyr Glu Thr Asn Leu Thr Phe 
            580                 585                 590         


Val Gly Cys Val Gly Met Leu Asp Pro Pro Arg Ile Glu Val Ala Ser 
        595                 600                 605             


Ser Val Lys Leu Cys Arg Gln Ala Gly Ile Arg Val Ile Met Ile Thr 
    610                 615                 620                 


Gly Asp Asn Lys Gly Thr Ala Val Ala Ile Cys Arg Arg Ile Gly Ile 
625                 630                 635                 640 


Phe Gly Gln Asp Glu Asp Val Thr Ser Lys Ala Phe Thr Gly Arg Glu 
                645                 650                 655     


Phe Asp Glu Leu Asn Pro Ser Ala Gln Arg Asp Ala Cys Leu Asn Ala 
            660                 665                 670         


Arg Cys Phe Ala Arg Val Glu Pro Ser His Lys Ser Lys Ile Val Glu 
        675                 680                 685             


Phe Leu Gln Ser Phe Asp Glu Ile Thr Ala Met Thr Gly Asp Gly Val 
    690                 695                 700                 


Asn Asp Ala Pro Ala Leu Lys Lys Ala Glu Ile Gly Ile Ala Met Gly 
705                 710                 715                 720 


Ser Gly Thr Ala Val Ala Lys Thr Ala Ser Glu Met Val Leu Ala Asp 
                725                 730                 735     


Asp Asn Phe Ser Thr Ile Val Ala Ala Val Glu Glu Gly Arg Ala Ile 
            740                 745                 750         


Tyr Asn Asn Met Lys Gln Phe Ile Arg Tyr Leu Ile Ser Ser Asn Val 
        755                 760                 765             


Gly Glu Val Val Cys Ile Phe Leu Thr Ala Ala Leu Gly Phe Pro Glu 
    770                 775                 780                 


Ala Leu Ile Pro Val Gln Leu Leu Trp Val Asn Leu Val Thr Asp Gly 
785                 790                 795                 800 


Leu Pro Ala Thr Ala Leu Gly Phe Asn Pro Pro Asp Leu Asp Ile Met 
                805                 810                 815     


Asn Lys Pro Pro Arg Asn Pro Lys Glu Pro Leu Ile Ser Gly Trp Leu 
            820                 825                 830         


Phe Phe Arg Tyr Leu Ala Ile Gly Cys Tyr Val Gly Ala Ala Thr Val 
        835                 840                 845             


Gly Ala Ala Ala Trp Trp Phe Ile Ala Ala Asp Gly Gly Pro Arg Val 
    850                 855                 860                 


Ser Phe Tyr Gln Leu Ser His Phe Leu Gln Cys Lys Glu Asp Asn Pro 
865                 870                 875                 880 


Asp Phe Glu Gly Val Asp Cys Ala Ile Phe Glu Ser Pro Tyr Pro Met 
                885                 890                 895     


Thr Met Ala Leu Ser Val Leu Val Thr Ile Glu Met Cys Asn Ala Leu 
            900                 905                 910         


Asn Ser Leu Ser Glu Asn Gln Ser Leu Leu Arg Met Pro Pro Trp Glu 
        915                 920                 925             


Asn Ile Trp Leu Val Gly Ser Ile Cys Leu Ser Met Ser Leu His Phe 
    930                 935                 940                 


Leu Ile Leu Tyr Val Glu Pro Leu Pro Leu Ile Phe Gln Ile Thr Pro 
945                 950                 955                 960 


Leu Asn Val Thr Gln Trp Leu Met Val Leu Lys Ile Ser Leu Pro Val 
                965                 970                 975     


Ile Leu Met Asp Glu Thr Leu Lys Phe Val Ala Arg Asn Tyr Leu Glu 
            980                 985                 990         


Pro Ala Ile Leu Glu 
        995         


<210>  115
<211>  6666
<212>  DNA
<213>  Homo sapiens

<400>  115
atggtcaatg agaatacgag gatgtacatt ccagaggaaa accaccaagg ttccaactat       60

gggagcccac gccccgccca tgccaacatg aatgccaatg cggcagcggg gctggcccct      120

gagcacatcc ccaccccggg ggctgccctg tcgtggcagg cggccatcga cgcagcccgg      180

caggctaagc tgatgggcag cgctggcaat gcgaccatct ccacagtcag ctccacgcag      240

cggaagcggc agcaatatgg gaaacccaag aagcagggca gcaccacggc cacacgcccg      300

ccccgagccc tgctctgcct gaccctgaag aaccccatcc ggagggcctg catcagcatt      360

gtcgaatgga aaccatttga aataattatt ttactgacta tttttgccaa ttgtgtggcc      420

ttagcgatct atattccctt tccagaagat gattccaacg ccaccaattc caacctggaa      480

cgagtggaat atctctttct cataattttt acggtggaag cgtttttaaa agtaatcgcc      540

tatggactcc tctttcaccc caatgcctac ctccgcaacg gctggaacct actagatttt      600

ataattgtgg ttgtggggct ttttagtgca attttagaac aagcaaccaa agcagatggg      660

gcaaacgctc tcggagggaa aggggccgga tttgatgtga aggcgctgag ggccttccgc      720

gtgctgcgcc ccctgcggct ggtgtccgga gtcccaagtc tccaggtggt cctgaattcc      780

atcatcaagg ccatggtccc cctgctgcac atcgccctgc ttgtgctgtt tgtcatcatc      840

atctacgcca tcatcggctt ggagctcttc atggggaaga tgcacaagac ctgctacaac      900

caggagggca tagcagatgt tccagcagaa gatgaccctt ccccttgtgc gctggaaacg      960

ggccacgggc ggcagtgcca gaacggcacg gtgtgcaagc ccggctggga tggtcccaag     1020

cacggcatca ccaactttga caactttgcc ttcgccatgc tcacggtgtt ccagtgcatc     1080

accatggagg gctggacgga cgtgctgtac tgggtcaatg atgccgtagg aagggactgg     1140

ccctggatct attttgttac actaatcatc atagggtcat tttttgtact taacttggtt     1200

ctcggtgtgc ttagcggaga gttttccaaa gagagggaga aggccaaggc ccggggagat     1260

ttccagaagc tgcgggagaa gcagcagcta gaagaggatc tcaaaggcta cctggattgg     1320

atcactcagg ccgaagacat cgatcctgag aatgaggacg aaggcatgga tgaggagaag     1380

ccccgaaaca tgagcatgcc caccagtgag accgagtccg tcaacaccga aaacgtggct     1440

ggaggtgaca tcgagggaga aaactgcggg gccaggctgg cccaccggat ctccaagtca     1500

aagttcagcc gctactggcg ccggtggaat cggttctgca gaaggaagtg ccgcgccgca     1560

gtcaagtcta atgtcttcta ctggctggtg attttcctgg tgttcctcaa cacgctcacc     1620

attgcctctg agcactacaa ccagcccaac tggctcacag aagtccaaga cacggcaaac     1680

aaggccctgc tggccctgtt cacggcagag atgctcctga agatgtacag cctgggcctg     1740

caggcctact tcgtgtccct cttcaaccgc tttgactgct tcgtcgtgtg tggcggcatc     1800

ctggagacca tcctggtgga gaccaagatc atgtccccac tgggcatctc cgtgctcaga     1860

tgcgtccggc tgctgaggat tttcaagatc acgaggtact ggaactcctt gagcaacctg     1920

gtggcatcct tgctgaactc tgtgcgctcc atcgcctccc tgctccttct cctcttcctc     1980

ttcatcatca tcttctccct cctggggatg cagctctttg gaggaaagtt caactttgat     2040

gagatgcaga cccggaggag cacattcgat aacttccccc agtccctcct cactgtgttt     2100

cagatcctga ccggggagga ctggaattcg gtgatgtatg atgggatcat ggcttatggc     2160

ggcccctctt ttccagggat gttagtctgt atttacttca tcatcctctt catctgtgga     2220

aactatatcc tactgaatgt gttcttggcc attgctgtgg acaacctggc tgatgctgag     2280

agcctcacat ctgcccaaaa ggaggaggaa gaggagaagg agagaaagaa gctggccagg     2340

actgccagcc cagagaagaa acaagagttg gtggagaagc cggcagtggg ggaatccaag     2400

gaggagaaga ttgagctgaa atccatcacg gctgacggag agtctccacc cgccaccaag     2460

atcaacatgg atgacctcca gcccaatgaa aatgaggata agagccccta ccccaaccca     2520

gaaactacag gagaagagga tgaggaggag ccagagatgc ctgtcggccc tcgcccacga     2580

ccactctctg agcttcacct taaggaaaag gcagtgccca tgccagaagc cagcgcgttt     2640

ttcatcttca gctctaacaa caggtttcgc ctccagtgcc accgcattgt caatgacacg     2700

atcttcacca acctgatcct cttcttcatt ctgctcagca gcatttccct ggctgctgag     2760

gacccggtcc agcacacctc cttcaggaac catattctgt tttattttga tattgttttt     2820

accaccattt tcaccattga aattgctctg aagatcctag gcaatgcaga ctatgtcttc     2880

actagtatct ttacattaga aattatcctt aagatgactg cttatggggc tttcttgcac     2940

aagggttctt tctgccggaa ctacttcaac atcctggacc tgctggtggt cagcgtgtcc     3000

ctcatctcct ttggcatcca gtccagtgca atcaatgtcg tgaagatctt gcgagtcctg     3060

cgagtactca ggcccctgag ggccatcaac agggccaagg ggctaaagca tgtggttcag     3120

tgtgtgtttg tcgccatccg gaccatcggg aacatcgtga ttgtcaccac cctgctgcag     3180

ttcatgtttg cctgcatcgg ggtccagctc ttcaagggaa agctgtacac ctgttcagac     3240

agttccaagc agacagaggc ggaatgcaag ggcaactaca tcacgtacaa agacggggag     3300

gttgaccacc ccatcatcca accccgcagc tgggagaaca gcaagtttga ctttgacaat     3360

gttctggcag ccatgatggc cctcttcacc gtctccacct tcgaagggtg gccagagctg     3420

ctgtaccgct ccatcgactc ccacacggaa gacaagggcc ccatctacaa ctaccgtgtg     3480

gagatctcca tcttcttcat catctacatc atcatcatcg ccttcttcat gatgaacatc     3540

ttcgtgggct tcgtcatcgt cacctttcag gagcaggggg agcaggagta caagaactgt     3600

gagctggaca agaaccagcg acagtgcgtg gaatacgccc tcaaggcccg gcccctgcgg     3660

aggtacatcc ccaagaacca gcaccagtac aaagtgtggt acgtggtcaa ctccacctac     3720

ttcgagtacc tgatgttcgt cctcatcctg ctcaacacca tctgcctggc catgcagcac     3780

tacggccaga gctgcctgtt caaaatcgcc atgaacatcc tcaacatgct cttcactggc     3840

ctcttcaccg tggagatgat cctgaagctc attgccttca aacccaaggg ttactttagt     3900

gatccctgga atgtttttga cttcctcatc gtaattggca gcataattga cgtcattctc     3960

agtgagacta atcactattt ctgtgatgca tggaatacat ttgacgcctt gattgttgtg     4020

ggtagcattg ttgatatagc aatcaccgag gtaaacccag ctgaacatac ccaatgctct     4080

ccctctatga acgcagagga aaactcccgc atctccatca ccttcttccg cctgttccgg     4140

gtcatgcgtc tggtgaagct gctgagccgt ggggagggca tccggacgct gctgtggacc     4200

ttcatcaagt ccttccaggc cctgccctat gtggccctcc tgatcgtgat gctgttcttc     4260

atctacgcgg tgatcgggat gcaggtgttt gggaaaattg ccctgaatga taccacagag     4320

atcaaccgga acaacaactt tcagaccttc ccccaggccg tgctgctcct cttcaggtgt     4380

gccaccgggg aggcctggca ggacatcatg ctggcctgca tgccaggcaa gaagtgtgcc     4440

ccagagtccg agcccagcaa cagcacggag ggtgaaacac cctgtggtag cagctttgct     4500

gtcttctact tcatcagctt ctacatgctc tgtgccttcc tgatcatcaa cctctttgta     4560

gctgtcatca tggacaactt tgactacctg acaagggact ggtccatcct tggtccccac     4620

cacctggatg agtttaaaag aatctgggca gagtatgacc ctgaagccaa gggtcgtatc     4680

aaacacctgg atgtggtgac cctcctccgg cggattcagc cgccactagg ttttgggaag     4740

ctgtgccctc accgcgtggc ttgcaaacgc ctggtctcca tgaacatgcc tctgaacagc     4800

gacgggacag tcatgttcaa tgccaccctg tttgccctgg tcaggacggc cctgaggatc     4860

aaaacagaag ggaacctaga acaagccaat gaggagctgc gggcgatcat caagaagatc     4920

tggaagcgga ccagcatgaa gctgctggac caggtggtgc cccctgcagg tgatgatgag     4980

gtcaccgttg gcaagttcta cgccacgttc ctgatccagg agtacttccg gaagttcaag     5040

aagcgcaaag agcagggcct tgtgggcaag ccctcccaga ggaacgcgct gtctctgcag     5100

gctggcttgc gcacactgca tgacatcggg cctgagatcc gacgggccat ctctggagat     5160

ctcaccgctg aggaggagct ggacaaggcc atgaaggagg ctgtgtccgc tgcttctgaa     5220

gatgacatct tcaggagggc cggtggcctg ttcggcaacc acgtcagcta ctaccaaagc     5280

gacggccgga gcgccttccc ccagaccttc accactcagc gcccgctgca catcaacaag     5340

gcgggcagca gccagggcga cactgagtcg ccatcccacg agaagctggt ggactccacc     5400

ttcaccccga gcagctactc gtccaccggc tccaacgcca acatcaacaa cgccaacaac     5460

accgccctgg gtcgcctccc tcgccccgcc ggctacccca gcacggtcag cactgtggag     5520

ggccacgggc cccccttgtc ccctgccatc cgggtgcagg aggtggcgtg gaagctcagc     5580

tccaacaggg aaaggcacgt tccgatgtgt gaggatctgg agctcaggag ggattcaggc     5640

tcagcaggga ctcaggctca ctgccttctg ctcaggagag caaacccctc taggtgccac     5700

tcccgggaga gccaggcagc catggcgggt caggaggaga cgtctcagga tgagacctat     5760

gaagtgaaga tgaaccatga cacggaggcc tgcagtgagc ccagcctgct ctccacagag     5820

atgctctcct accaggatga cgaaaatcgg caactgacgc tcccagagga ggacaagagg     5880

gacatccggc aatctccgaa gaggggtttc ctccgctctg cctcactagg tcgaagggcc     5940

tccttccacc tggaatgtct gaagcgacag aaggaccgag ggggagacat ctctcagaag     6000

acagtcctgc ccttgcatct ggttcatcat caggcattgg cagtggcagg cctgagcccc     6060

ctcctccaga gaagccattc ccctgcctca ttccctaggc cttttgccac cccaccagcc     6120

acacctggca gccgaggctg gcccccacag cccgtcccca ccctgcggct tgagggggtc     6180

gagtccagtg agaaactcaa cagcagcttc ccatccatcc actgcggctc ctgggctgag     6240

accacccccg gtggcggggg cagcagcgcc gcccggagag tccggcccgt ctccctcatg     6300

gtgcccagcc aggctggggc cccagggagg cagttccacg gcagtgccag cagcctggtg     6360

gaagcggtct tgatttcaga aggactgggg cagtttgctc aagatcccaa gttcatcgag     6420

gtcaccaccc aggagctggc cgacgcctgc gacatgacca tagaggagat ggagagcgcg     6480

gccgacaaca tcctcagcgg gggcgcccca cagagcccca atggcgccct cttacccttt     6540

gtgaactgca gggacgcggg gcaggaccga gccgggggcg aagaggacgc gggctgtgtg     6600

cgcgcgcggg gtcgaccgag tgaggaggag ctccaggaca gcagggtcta cgtcagcagc     6660

ctgtag                                                                6666


<210>  116
<211>  2221
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Thr Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu 
    1385                 1390                 1395             


Trp Thr  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Thr Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Thr Glu  Gly Glu Thr Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Thr  Val Ser Thr Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Glu Arg  His Val Pro Met Cys  Glu Asp Leu Glu Leu  Arg Arg Asp 
    1865                 1870                 1875             


Ser Gly  Ser Ala Gly Thr Gln  Ala His Cys Leu Leu  Leu Arg Arg 
    1880                 1885                 1890             


Ala Asn  Pro Ser Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1895                 1900                 1905             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1910                 1915                 1920             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1925                 1930                 1935             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1940                 1945                 1950             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1955                 1960                 1965             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1970                 1975                 1980             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1985                 1990                 1995             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    2000                 2005                 2010             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    2015                 2020                 2025             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    2030                 2035                 2040             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    2045                 2050                 2055             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    2060                 2065                 2070             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2090                 2095                 2100             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2105                 2110                 2115             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2120                 2125                 2130             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2135                 2140                 2145             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2150                 2155                 2160             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2165                 2170                 2175             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2180                 2185                 2190             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2195                 2200                 2205             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2210                 2215                 2220     


<210>  117
<211>  1869
<212>  DNA
<213>  Homo sapiens

<400>  117
atgagggaac agctcaaagg ccacgagact caaacaactt gctgggacca tcccaaaatg       60

acagagctct accagtcttt agctgacctg aataatgtca gattctcagc ttataggact      120

gccatgaaac tccgaagact gcagaaggcc ctttgcttgg atctcttgag cctgtcagct      180

gcatgtgatg ccttggacca gcacaacctc aagcaaaatg accagcccat ggatatcctg      240

cagattatta attgtttgac cactatttat gaccgcctgg agcaagagca caacaatttg      300

gtcaacgtcc ctctctgcgt ggatatgtgt ctgaactggc tgctgaatgt ttatgatacg      360

ggacgaacag ggaggatccg tgtcctgtct tttaaaactg gcatcatttc cctgtgtaaa      420

gcacatttgg aagacaagta cagatacctt ttcaagcaag tggcaagttc aacaggattt      480

tgtgaccagc gcaggctggg cctccttctg catgattcta tccaaattcc aagacagttg      540

ggtgaagttg catcctttgg gggcagtaac attgagccaa gtgtccggag ctgcttccaa      600

tttgctaata ataagccaga gatcgaagcg gccctcttcc tagactggat gagactggaa      660

ccccagtcca tggtgtggct gcccgtcctg cacagagtgg ctgctgcaga aactgccaag      720

catcaggcca aatgtaacat ctgcaaagag tgtccaatca ttggattcag gtacaggagt      780

ctaaagcact ttaattatga catctgccaa agctgctttt tttctggtcg agttgcaaaa      840

ggccataaaa tgcactatcc catggtggaa tattgcactc cgactacatc aggagaagat      900

gttcgagact ttgccaaggt actaaaaaac aaatttcgaa ccaaaaggta ttttgcgaag      960

catccccgaa tgggctacct gccagtgcag actgtcttag agggggacaa catggaaacg     1020

cctgcctcgt cccctcagct ttcacacgat gatactcatt cacgcattga acattatgct     1080

agcaggctag cagaaatgga aaacagcaat ggatcttatc taaatgatag catctctcct     1140

aatgagagca tagatgatga acatttgtta atccagcatt actgccaaag tttgaaccag     1200

gactcccccc tgagccagcc tcgtagtcct gcccagatct tgatttcctt agagagtgag     1260

gaaagagggg agctagagag aatcctagca gatcttgagg aagaaaacag gaatctgcaa     1320

gcagaatatg accgtctaaa gcagcagcac gaacataaag gcctgtcccc actgccgtcc     1380

cctcctgaaa tgatgcccac ctctccccag agtccccggg atgctgagct cattgctgag     1440

gccaagctac tgcgtcaaca caaaggccgc ctggaagcca ggatgcaaat cctggaagac     1500

cacaataaac agctggagtc acagttacac aggctaaggc agctgctgga gcaaccccag     1560

gcagaggcca aagtgaatgg cacaacggtg tcctctcctt ctacctctct acagaggtcc     1620

gacagcagtc agcctatgct gctccgagtg gttggcagtc aaacttcgga ctccatgggt     1680

gaggaagatc ttctcagtcc tccccaggac acaagcacag ggttagagga ggtgatggag     1740

caactcaaca actccttccc tagttcaaga ggacacaatg taggaagtct tttccacatg     1800

gcagatgatt tgggcagagc gatggagtcc ttagtatcag tcatgacaga tgaagaagga     1860

gcagaataa                                                             1869


<210>  118
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Arg Glu Gln Leu Lys Gly His Glu Thr Gln Thr Thr Cys Trp Asp 
1               5                   10                  15      


His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn 
            20                  25                  30          


Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln 
        35                  40                  45              


Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala 
    50                  55                  60                  


Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile Leu 
65                  70                  75                  80  


Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln Glu 
                85                  90                  95      


His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu Asn 
            100                 105                 110         


Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg Val 
        115                 120                 125             


Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu Glu 
    130                 135                 140                 


Asp Lys Tyr Arg Tyr Leu Phe Lys Gln Val Ala Ser Ser Thr Gly Phe 
145                 150                 155                 160 


Cys Asp Gln Arg Arg Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile 
                165                 170                 175     


Pro Arg Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu 
            180                 185                 190         


Pro Ser Val Arg Ser Cys Phe Gln Phe Ala Asn Asn Lys Pro Glu Ile 
        195                 200                 205             


Glu Ala Ala Leu Phe Leu Asp Trp Met Arg Leu Glu Pro Gln Ser Met 
    210                 215                 220                 


Val Trp Leu Pro Val Leu His Arg Val Ala Ala Ala Glu Thr Ala Lys 
225                 230                 235                 240 


His Gln Ala Lys Cys Asn Ile Cys Lys Glu Cys Pro Ile Ile Gly Phe 
                245                 250                 255     


Arg Tyr Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys 
            260                 265                 270         


Phe Phe Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met 
        275                 280                 285             


Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe 
    290                 295                 300                 


Ala Lys Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys 
305                 310                 315                 320 


His Pro Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp 
                325                 330                 335     


Asn Met Glu Thr Pro Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr 
            340                 345                 350         


His Ser Arg Ile Glu His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn 
        355                 360                 365             


Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile 
    370                 375                 380                 


Asp Asp Glu His Leu Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln 
385                 390                 395                 400 


Asp Ser Pro Leu Ser Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser 
                405                 410                 415     


Leu Glu Ser Glu Glu Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu 
            420                 425                 430         


Glu Glu Glu Asn Arg Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln 
        435                 440                 445             


Gln His Glu His Lys Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met 
    450                 455                 460                 


Met Pro Thr Ser Pro Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu 
465                 470                 475                 480 


Ala Lys Leu Leu Arg Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln 
                485                 490                 495     


Ile Leu Glu Asp His Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu 
            500                 505                 510         


Arg Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr 
        515                 520                 525             


Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln 
    530                 535                 540                 


Pro Met Leu Leu Arg Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly 
545                 550                 555                 560 


Glu Glu Asp Leu Leu Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu 
                565                 570                 575     


Glu Val Met Glu Gln Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly His 
            580                 585                 590         


Asn Val Gly Ser Leu Phe His Met Ala Asp Asp Leu Gly Arg Ala Met 
        595                 600                 605             


Glu Ser Leu Val Ser Val Met Thr Asp Glu Glu Gly Ala Glu 
    610                 615                 620         


<210>  119
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  119
atgggagggc atttttggcc cccagaacct tacacggtgt ttatgtgggg aagcccctgg       60

gaagcagaca gtcctagggt gaagctgaga ggcagagaga aggggagaca gacagagggt      120

ggggctttcc cccttgtctc cagtgccctt tctggtgacc ctcggttctt ttcccccacc      180

acccccccag cggagcccat cgtggtgagg cttaaggagg tccgactgca gagggacgac      240

ttcgagattc tgaaggtgat cggacgcggg gcgttcagcg aggtagcggt agtgaagatg      300

aagcagacgg gccaggtgta tgccatgaag atcatgaaca agtgggacat gctgaagagg      360

ggcgaggtgt cgtgcttccg tgaggagagg gacgtgttgg tgaatgggga ccggcggtgg      420

atcacgcagc tgcacttcgc cttccaggat gagaactacc tgtacctggt catggagtat      480

tacgtgggcg gggacctgct gacactgctg agcaagtttg gggagcggat tccggccgag      540

atggcgcgct tctacctggc ggagattgtc atggccatag actcggtgca ccggcttggc      600

tacgtgcaca gggacatcaa acccgacaac atcctgctgg accgctgtgg ccacatccgc      660

ctggccgact tcggctcttg cctcaagctg cgggcagatg gaacggtgcg gtcgctggtg      720

gctgtgggca ccccagacta cctgtccccc gagatcctgc aggctgtggg cggtgggcct      780

gggacaggca gctacgggcc cgagtgtgac tggtgggcgc tgggtgtatt cgcctatgaa      840

atgttctatg ggcagacgcc cttctacgcg gattccacgg cggagaccta tggcaagatc      900

gtccactaca aggagcacct ctctctgccg ctggtggacg aaggggtccc tgaggaggct      960

cgagacttca ttcagcggtt gctgtgtccc ccggagacac ggctgggccg gggtggagca     1020

ggcgacttcc ggacacatcc cttcttcttt ggcctcgact gggatggtct ccgggacagc     1080

gtgcccccct ttacaccgga tttcgaaggt gccaccgaca catgcaactt cgacttggtg     1140

gaggacgggc tcactgccat ggtgagcggg ggcggggaga cactgtcgga cattcgggaa     1200

ggtgcgccgc taggggtcca cctgcctttt gtgggctact cctactcctg catggccctc     1260

agggacagtg aggtcccagg ccccacaccc atggaactgg aggccgagca gctgcttgag     1320

ccacacgtgc aagcgcccag cctggagccc tcggtgtccc cacaggatga aacagctgaa     1380

gtggcagttc cagcggctgt ccctgcggca gaggctgagg ccgaggtgac gctgcgggag     1440

ctccaggaag ccctggagga ggaggtgctc acccggcaga gcctgagccg ggagatggag     1500

gccatccgca cggacaacca gaacttcgcc agtcaactac gcgaggcaga ggctcggaac     1560

cgggacctag aggcacacgt ccggcagttg caggagcgga tggagttgct gcaggcagag     1620

ggagccacag ctgtcacggg ggtccccagt ccccgggcca cggatccacc ttcccatcta     1680

gatggccccc cggccgtggc tgtgggccag tgcccgctgg tggggccagg ccccatgcac     1740

cgccgccacc tgctgctccc tgccagggtc cctaggcctg gcctatcgga ggcgctttcc     1800

ctgctcctgt tcgccgttgt tctgtctcgt gccgccgccc tgggctgcat tgggttggtg     1860

gcccacgccg gccaactcac cgcagtctgg cgccgcccag gagccgcccg cgctccctga     1920


<210>  120
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Gly Gly His Phe Trp Pro Pro Glu Pro Tyr Thr Val Phe Met Trp 
1               5                   10                  15      


Gly Ser Pro Trp Glu Ala Asp Ser Pro Arg Val Lys Leu Arg Gly Arg 
            20                  25                  30          


Glu Lys Gly Arg Gln Thr Glu Gly Gly Ala Phe Pro Leu Val Ser Ser 
        35                  40                  45              


Ala Leu Ser Gly Asp Pro Arg Phe Phe Ser Pro Thr Thr Pro Pro Ala 
    50                  55                  60                  


Glu Pro Ile Val Val Arg Leu Lys Glu Val Arg Leu Gln Arg Asp Asp 
65                  70                  75                  80  


Phe Glu Ile Leu Lys Val Ile Gly Arg Gly Ala Phe Ser Glu Val Ala 
                85                  90                  95      


Val Val Lys Met Lys Gln Thr Gly Gln Val Tyr Ala Met Lys Ile Met 
            100                 105                 110         


Asn Lys Trp Asp Met Leu Lys Arg Gly Glu Val Ser Cys Phe Arg Glu 
        115                 120                 125             


Glu Arg Asp Val Leu Val Asn Gly Asp Arg Arg Trp Ile Thr Gln Leu 
    130                 135                 140                 


His Phe Ala Phe Gln Asp Glu Asn Tyr Leu Tyr Leu Val Met Glu Tyr 
145                 150                 155                 160 


Tyr Val Gly Gly Asp Leu Leu Thr Leu Leu Ser Lys Phe Gly Glu Arg 
                165                 170                 175     


Ile Pro Ala Glu Met Ala Arg Phe Tyr Leu Ala Glu Ile Val Met Ala 
            180                 185                 190         


Ile Asp Ser Val His Arg Leu Gly Tyr Val His Arg Asp Ile Lys Pro 
        195                 200                 205             


Asp Asn Ile Leu Leu Asp Arg Cys Gly His Ile Arg Leu Ala Asp Phe 
    210                 215                 220                 


Gly Ser Cys Leu Lys Leu Arg Ala Asp Gly Thr Val Arg Ser Leu Val 
225                 230                 235                 240 


Ala Val Gly Thr Pro Asp Tyr Leu Ser Pro Glu Ile Leu Gln Ala Val 
                245                 250                 255     


Gly Gly Gly Pro Gly Thr Gly Ser Tyr Gly Pro Glu Cys Asp Trp Trp 
            260                 265                 270         


Ala Leu Gly Val Phe Ala Tyr Glu Met Phe Tyr Gly Gln Thr Pro Phe 
        275                 280                 285             


Tyr Ala Asp Ser Thr Ala Glu Thr Tyr Gly Lys Ile Val His Tyr Lys 
    290                 295                 300                 


Glu His Leu Ser Leu Pro Leu Val Asp Glu Gly Val Pro Glu Glu Ala 
305                 310                 315                 320 


Arg Asp Phe Ile Gln Arg Leu Leu Cys Pro Pro Glu Thr Arg Leu Gly 
                325                 330                 335     


Arg Gly Gly Ala Gly Asp Phe Arg Thr His Pro Phe Phe Phe Gly Leu 
            340                 345                 350         


Asp Trp Asp Gly Leu Arg Asp Ser Val Pro Pro Phe Thr Pro Asp Phe 
        355                 360                 365             


Glu Gly Ala Thr Asp Thr Cys Asn Phe Asp Leu Val Glu Asp Gly Leu 
    370                 375                 380                 


Thr Ala Met Val Ser Gly Gly Gly Glu Thr Leu Ser Asp Ile Arg Glu 
385                 390                 395                 400 


Gly Ala Pro Leu Gly Val His Leu Pro Phe Val Gly Tyr Ser Tyr Ser 
                405                 410                 415     


Cys Met Ala Leu Arg Asp Ser Glu Val Pro Gly Pro Thr Pro Met Glu 
            420                 425                 430         


Leu Glu Ala Glu Gln Leu Leu Glu Pro His Val Gln Ala Pro Ser Leu 
        435                 440                 445             


Glu Pro Ser Val Ser Pro Gln Asp Glu Thr Ala Glu Val Ala Val Pro 
    450                 455                 460                 


Ala Ala Val Pro Ala Ala Glu Ala Glu Ala Glu Val Thr Leu Arg Glu 
465                 470                 475                 480 


Leu Gln Glu Ala Leu Glu Glu Glu Val Leu Thr Arg Gln Ser Leu Ser 
                485                 490                 495     


Arg Glu Met Glu Ala Ile Arg Thr Asp Asn Gln Asn Phe Ala Ser Gln 
            500                 505                 510         


Leu Arg Glu Ala Glu Ala Arg Asn Arg Asp Leu Glu Ala His Val Arg 
        515                 520                 525             


Gln Leu Gln Glu Arg Met Glu Leu Leu Gln Ala Glu Gly Ala Thr Ala 
    530                 535                 540                 


Val Thr Gly Val Pro Ser Pro Arg Ala Thr Asp Pro Pro Ser His Leu 
545                 550                 555                 560 


Asp Gly Pro Pro Ala Val Ala Val Gly Gln Cys Pro Leu Val Gly Pro 
                565                 570                 575     


Gly Pro Met His Arg Arg His Leu Leu Leu Pro Ala Arg Val Pro Arg 
            580                 585                 590         


Pro Gly Leu Ser Glu Ala Leu Ser Leu Leu Leu Phe Ala Val Val Leu 
        595                 600                 605             


Ser Arg Ala Ala Ala Leu Gly Cys Ile Gly Leu Val Ala His Ala Gly 
    610                 615                 620                 


Gln Leu Thr Ala Val Trp Arg Arg Pro Gly Ala Ala Arg Ala Pro 
625                 630                 635                 


<210>  121
<211>  7740
<212>  DNA
<213>  Homo sapiens

<400>  121
atggccgagg cggtgaagcc ccagcgccgg gccaaggcca aggccagccg gactaaaaca       60

aaggaaaaga agaagtatga aactcctcag agggaagagt ccagtgaagt ctcccttcca      120

aaaacctcca gagagcagga aatcccttct ctagcctgtg aattcaaagg agaccatctg      180

aaggtggtaa ctgattccca gctccaggat gatgccagtg gacaaaatga gagtgaaatg      240

tttgatgtac cactcacctc cttaactata agcaatgaag agtccctgac gtgtaacaca      300

gagcccccaa aggaaggggg agaggccaga ccctgtgtgg gggacagtgc agtcactcca      360

aaggtccacc ctggagacaa tgttggaact aaagtagaaa cccccaagaa cttcacagag      420

gtagaggaaa atatgtcggt acaaggtgga ctttcagaaa gtgcacccca atctaatttt      480

tcttatactc agccagcaat ggaaaatata caagtcagag aaactcagaa tagtaaagaa      540

gacaaacaag gcctggtttg ttcttcagag gtgccacaga atgttggctt gcagagttct      600

tgcccagcca aacatggttt tcagacacct agagtgaaga aactgtatcc ccagttgcca      660

gctgaaattg ctggagaagc accagctttg gtggcagtga aacccttgct tcgcagtgag      720

cgactctacc cagaactccc gtctcaactg gaactagtac catttactaa agaacagcta      780

aaaatcttgg agcctggttc atggctggaa aatgttgagt catatttaga agaatttgac      840

agcatggctc atcaagacag gcatgaattt tatgagttgc ttttgaacta ctcacgatgt      900

aggaagcaac tgctgctggc tgaagctgag ctgcttactc tgacatctga ttgccaaaat      960

gctaaaagtc ggctgtggca gtttaaggag gaacaaatgt ctgtacaggg tatctgtgca     1020

gatcaagtga aagttttcag ctatcatcgc taccaaagag tagaaatgaa tgaaaatgca     1080

ctggtggagc taaagaagct attcgatgcc aaatctgagc acctccacca gaccctggcc     1140

cttcattctt atacttctgt gctctcaaga ttgcaagtgg agtcttacat ctatgcattg     1200

ctcagtagtt cagctgttct gagatcttca gcaattcacc agcaaggccg agcgtctaag     1260

cagacagaaa gcattccctc tgatctgtgt caactaaagg aatgcattag tgtcttattc     1320

atgttcacca ggagagttaa tgaagatact cagtttcatg atgatattct tctctggctg     1380

cagaaattgg tatccgtgct acaaagagtt ggctgtcctg gagatcacct cttccttcta     1440

aaccatattc ttcgatgccc cgctggtgtt agtaaatggg ctgttccttt tatccagatc     1500

aaagtgttgc ataacccatc aggggtcttt cattttatgc aatcccttgc cctgctgatg     1560

tctcctgtca aaaatcgagc tgagtttatg tgccacatga agcccagcga gcggaagcca     1620

tcctcctcag ggcctgggtc tgggacttgg acgctagtag acgaaggagg agaagaggat     1680

gaagaccctg agaccagttg gattctcctt aatgaagatg atttggttac cattttagca     1740

cagttcccct ttcatgaact ctttcagcat cttcttgggt ttaaagcaaa aggtgattat     1800

ttacctgaaa caacaagacc tcaagagatg atgaaaattt ttgcctttgc caactcacta     1860

gtggaacttc tggctgtggg gttagaaacc tttaatagag cacgctatag gcagtttgtg     1920

aagcgaattg gttatatgat caggatgact cttggttatg taagtgacca ttgggcacag     1980

tatgtgagcc ataaccaagg ctcaggattg gcccaacagc cctactctat ggagaaacta     2040

caggttgaat ttgatgaact gtttttgagg gctgtcctac atgtgctgaa ggccaaaaga     2100

cttggcattt ggctgtttat gtccgagatg ccctttggga ctctgtctgt gcaaatgctg     2160

tggaagctct tctacctcat gcaccaggtg gagagcgaga acctgcagca gctctcctcc     2220

tccctgcagc ccgcccagtg caagcagcag ctccaagacc cagaacattt taccaacttt     2280

gagaagtgtc tttcttctat gaatagctca gaagagattt gccttctgac tacctttgct     2340

cagatggctc aggccagaag aaccaatgtg gacgaagact tcataaaaat tattgttctg     2400

gagatatatg aggtatctta tgtcaccttg tctaccagag agactttttc aaaggttggt     2460

cgagagcttt tagggactat cacagctgtt caccctgaga taatttccgt ccttctggat     2520

agagttcaag agaccattga ccaggttgga atggtttctc tatacttgtt taaagaactg     2580

cctttgtatc tttggcaacc ttctgcatct gagatagcgg tgattcggga ttggttattg     2640

aattacaacc tgacagtggt gaagaataaa ctggcctgtg ttattcttga aggactgaat     2700

tggggatttg ctaaacaggc tacccttcat ctggatcaag cagtccatgc tgaagtggct     2760

ttaatggttc ttgaagctta tcagaagtac cttgcacaga agccatatgc tgggattctc     2820

tctgaaagta tgaagcaggt ttcatatttg gccagtattg ttcgatatgg agagacaccc     2880

gagacctcat ttaaccaatg ggcctggaat ttaatcttga ggctaaaact gcacaaaaac     2940

gattatggaa tacagccgaa ttgtccagct gttcccttct ccgtcactgt gcctgacatg     3000

acagagtcac ccacgtttca tcctctcttg aaggctgtga aagcgggcat gcccattggc     3060

tgttatctag ccttatctat gacagctgtg ggccacagca ttgagaagtt ctgtgcagaa     3120

ggcatcccac tattgggaat tctggtccag tcaagacatt tgagaacagt ggttcatgtc     3180

ctggataaga ttctgccttt attttaccct tgccagtatt accttctgaa gaatgagcag     3240

tttttatcgc atctcctctt gttcctacac ttggacagcg gtgtccctca gggtgtcaca     3300

caacaggtca cccacaaggt ggcacagcac ctgacaggag ccagccatgg ggacaacgtg     3360

aagcttctca acagcatgat ccaggcacac atatctgtaa gcactcagcc caatgaagtg     3420

ggccccgttg ctgtgttgga gttctgggtt caggctctca taagccagca tctctggtac     3480

cgagaacaac ctatcctctt cctcatggac cacttgtgta aagcagcttt tcagctgatg     3540

caggaagact gcatacagaa attactctac caacaacata agaatgcctt gggttaccac     3600

tgtgaccgga gtctgctctc atctttggta agctggattg tggcaggcaa catcactcct     3660

tcctttgtgg agggcttggc cacgcccact caggtctggt ttgcctggac agtgctcaac     3720

atggaatcca tctttgaaga ggactcccag ctccggagag ttattgaagg ggaattggtg     3780

ataaactctg ctttcacccc tgaccaagct ctgaagaaag cccagaccca gctgaagctc     3840

cccatcgtgc catccctcca gaggctgctg atttatcgct gggcccacca ggctctggtc     3900

acaccttctg atcaccccct cctgccactc atttggcaga agttcttcct tctgtatctt     3960

caccgtccgg gaccacagta tgggttaccc atagatggtt gtattggaag aaggtttttt     4020

caaagtcctg ctcatatcaa tttgttgaaa gaaatgaaga gacgtttgac cgaggtggct     4080

gacttccacc atgctgcaag caaggccctc cgtgttccag cagagggcag tgaagggctg     4140

ccagagagcc actctggcac ccctggttac ctgacttcac cagaactgca caaggagctg     4200

gtgaggctct tcaatgtata tatattatgg ctagaagatg agaattttca aaaaggagat     4260

acctatatcc cttctctacc aaagcattat gatattcaca ggctagcaaa agtgatgcag     4320

aatcagcagg atctgtggat ggagtatttg aacatggagc gcatctatca tgagtttcag     4380

gagactgttg gtctgtggac acaggccaag cttgagtccc attccacacc ctgcagtttg     4440

tccgtgcagc tggacttcac tgatcctttg ctggctaaag aaagggtttt aagtaacttg     4500

cggaagcatg aggctcccca gcctcccctt gctctgcacc cgacgaagcc tcctgtgcca     4560

gttatttcct ctgctgtgct attgagtcag aaggacgcca cccagctggt gtgcacagac     4620

ctgaatctgt tgcaacagca ggccagaacc gcagctcttc gggaatctca gcaggttgct     4680

ctggatggtg agctgttaga cacaatgcca aagcagtatg tgaatcgtga agaacagacc     4740

acactacatt tggagtgcag aggcagcagc ggtaagaaat gccaaggagc cgcagttgtc     4800

acggttcagt ttgaaggcat gcataagaat gaagccataa gccaacagct tcatgtttta     4860

cggaaggaag tgaagcagtt gcaagcagaa gctgctaaac caccatcact taatattgtg     4920

gaagctgctg tacatgcaga aaacttgatc acggccttag tgaatgccta caagttgcag     4980

cctacacctg ggattcagaa agttggcatt agccttttct ttactattgt ggattacgtc     5040

agcgatgaga cgcagcgtca tcccccaaca aggcagttct ttacttcatg tattgagatc     5100

ttgggacagg tatttatcag tggcattaaa tcagagtgca gaaaagtact tgaaaccatt     5160

ctgaagaaca gcaggctctg ctccctgctg tctcctttct tcactcccaa tgctgcacct     5220

gcagagttca tacagctgta tgagcaagtg gtgaagtttc taagtgagga caacagtgat     5280

atgattttca tgctgctaac caagttcgat cttaaacaat ggttaagcgc cactaaacct     5340

cctctgtctg atcgtaccag gcttctggag tccattcact tggcacttac tgcctggggc     5400

cttgaaccag atgaggatat tttgatgcca tttaatcttt tctgtaagca ctggacttat     5460

cttcttctct accagtttcc tgaccagtac agtgacattc tcaggctgct tatgcaaagc     5520

tccgcggagc agcttctgag ccccgagtgt tggaaggcca ctctgagagc cctgggctgc     5580

tgcgccccca gctgccagca gggggcagcg tccaccgagg gcgccgtgct tcccagctct     5640

tctgatgctc tcttgtcaga caagcaggta atggagacta tacagtggct ttcagacttt     5700

ttttataagc ttcggttatc caagatggac tttaaaagct ttggtttatt ctcaaaatgg     5760

agtccttata tggctgatgt gaagacattc ttgggctacc ttgtgaaaag gctgattgac     5820

ttagaaatga cctgtttggc ccaagaccca actgccagca ggaaaacagt gctgaaatcc     5880

ctacattcag taatcattca gctctttaag ccatggatcc tggttttaga ggacaacgaa     5940

agcagccaac agcggcatta cccctggcta gagagtgata ctgtggtggc ctcaagcatt     6000

gtgcagctgt tcactgactg tattgactca ctgcatgaga gttttaaaga taagctgttg     6060

ccaggtgatg caggagccct ttggttgcac ctgatgcatt attgtgaagc atgtacagca     6120

cccaaaatgc cagagttcat tctgtacgct ttccatagca cgtaccggaa actgccatgg     6180

aaggacctgc accctgacca gatgctcatg gaggccttct tcaaagtgga acgaggaagc     6240

cccaagagct gtttcttatt tttggggtct gtactctgtg aagtcaactg ggttagtgtg     6300

ctctctgatg cctggaattc cagtccccac ccagaaaccc gcagcatgat tgtctgcctc     6360

cttttcatga tgattttatt ggcaaaggaa gttcaactgg tagaccaaac agattcacct     6420

ttacttagtc tccttggaca gacaagctca ctttcatggc atcttgtgga tattgtgtcg     6480

taccagagtg tgctaagtta tttcagcagc cattacccgc cgtccatcat cctggcaaaa     6540

gaatcttatg ctgaattaat catgaagctc ctaaaagtgt ctgcgggcct ttctattcct     6600

actgacagcc agaagcatct tgatgcagtt ccaaaatgcc aagcttttac tcatcagatg     6660

gttcaattcc tcagcaccct ggaacaaaat ggaaaaatca ccttagcagt cctagaacag     6720

gaaatgtcta agctcttaga cgatatcatt gtctttaacc cgcccgacat ggacagccag     6780

acccgccaca tggccctcag cagcctcttt atggaagtcc tgatgatgat gaacaacgcg     6840

actattccaa cagcagagtt ccttcggggc agtatccgga cctggattgg ccaaaaaatg     6900

catgggctgg tggtgctgcc ccttttaaca gcagcctgcc agagcctggc gtccgtccgc     6960

cacatggctg agactacaga agcctgcatc actgcctact tcaaagaaag ccctctcaat     7020

cagaattcag gatggggacc cattctggta tcccttcagg ttcccgagct caccatggaa     7080

gagttcctgc aggagtgcct caccttgggc agttacttga ctctttacgt ctacttgctt     7140

cagtgtttaa acagcgaaca gactttaagg aatgaaatga aagtgctgct catcttaagc     7200

aagtggctgg aacaggtgta cccaagctcc gtggaggaag aggcaaagct gtttttgtgg     7260

tggcaccaag tccttcagct ctccctcatt cagacagagc agaatgactc cgtcctgaca     7320

gaatctgtca ttcgaattct gctcttggtt cagagcaggc agaacctcgt ggctgaggag     7380

agactcagct ctgggatcct gggggcaatt gggtttggcc ggaagtcgcc tttgtctaac     7440

aggttccgag tggttgcccg aagcatggct gccttccttt cagttcaggt tcctatggaa     7500

gatcagatcc gtttgaggcc tggctctgaa ttacatctga cccccaaagc tcagcaggct     7560

ctgaatgctc ttgaatccat ggcatcaagt aagcagtatg ttgaatacca ggatcaaata     7620

ttgcaagcca cccaatttat aaggcatcct ggccattgcc ttcaagatgg gaaaagcttc     7680

ttggctcttc tcgttaactg tctgtatcca gaagtgcatt atttggacca catacgatag     7740


<210>  122
<211>  2579
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ala Glu Ala Val Lys Pro Gln Arg Arg Ala Lys Ala Lys Ala Ser 
1               5                   10                  15      


Arg Thr Lys Thr Lys Glu Lys Lys Lys Tyr Glu Thr Pro Gln Arg Glu 
            20                  25                  30          


Glu Ser Ser Glu Val Ser Leu Pro Lys Thr Ser Arg Glu Gln Glu Ile 
        35                  40                  45              


Pro Ser Leu Ala Cys Glu Phe Lys Gly Asp His Leu Lys Val Val Thr 
    50                  55                  60                  


Asp Ser Gln Leu Gln Asp Asp Ala Ser Gly Gln Asn Glu Ser Glu Met 
65                  70                  75                  80  


Phe Asp Val Pro Leu Thr Ser Leu Thr Ile Ser Asn Glu Glu Ser Leu 
                85                  90                  95      


Thr Cys Asn Thr Glu Pro Pro Lys Glu Gly Gly Glu Ala Arg Pro Cys 
            100                 105                 110         


Val Gly Asp Ser Ala Val Thr Pro Lys Val His Pro Gly Asp Asn Val 
        115                 120                 125             


Gly Thr Lys Val Glu Thr Pro Lys Asn Phe Thr Glu Val Glu Glu Asn 
    130                 135                 140                 


Met Ser Val Gln Gly Gly Leu Ser Glu Ser Ala Pro Gln Ser Asn Phe 
145                 150                 155                 160 


Ser Tyr Thr Gln Pro Ala Met Glu Asn Ile Gln Val Arg Glu Thr Gln 
                165                 170                 175     


Asn Ser Lys Glu Asp Lys Gln Gly Leu Val Cys Ser Ser Glu Val Pro 
            180                 185                 190         


Gln Asn Val Gly Leu Gln Ser Ser Cys Pro Ala Lys His Gly Phe Gln 
        195                 200                 205             


Thr Pro Arg Val Lys Lys Leu Tyr Pro Gln Leu Pro Ala Glu Ile Ala 
    210                 215                 220                 


Gly Glu Ala Pro Ala Leu Val Ala Val Lys Pro Leu Leu Arg Ser Glu 
225                 230                 235                 240 


Arg Leu Tyr Pro Glu Leu Pro Ser Gln Leu Glu Leu Val Pro Phe Thr 
                245                 250                 255     


Lys Glu Gln Leu Lys Ile Leu Glu Pro Gly Ser Trp Leu Glu Asn Val 
            260                 265                 270         


Glu Ser Tyr Leu Glu Glu Phe Asp Ser Met Ala His Gln Asp Arg His 
        275                 280                 285             


Glu Phe Tyr Glu Leu Leu Leu Asn Tyr Ser Arg Cys Arg Lys Gln Leu 
    290                 295                 300                 


Leu Leu Ala Glu Ala Glu Leu Leu Thr Leu Thr Ser Asp Cys Gln Asn 
305                 310                 315                 320 


Ala Lys Ser Arg Leu Trp Gln Phe Lys Glu Glu Gln Met Ser Val Gln 
                325                 330                 335     


Gly Ile Cys Ala Asp Gln Val Lys Val Phe Ser Tyr His Arg Tyr Gln 
            340                 345                 350         


Arg Val Glu Met Asn Glu Asn Ala Leu Val Glu Leu Lys Lys Leu Phe 
        355                 360                 365             


Asp Ala Lys Ser Glu His Leu His Gln Thr Leu Ala Leu His Ser Tyr 
    370                 375                 380                 


Thr Ser Val Leu Ser Arg Leu Gln Val Glu Ser Tyr Ile Tyr Ala Leu 
385                 390                 395                 400 


Leu Ser Ser Ser Ala Val Leu Arg Ser Ser Ala Ile His Gln Gln Gly 
                405                 410                 415     


Arg Ala Ser Lys Gln Thr Glu Ser Ile Pro Ser Asp Leu Cys Gln Leu 
            420                 425                 430         


Lys Glu Cys Ile Ser Val Leu Phe Met Phe Thr Arg Arg Val Asn Glu 
        435                 440                 445             


Asp Thr Gln Phe His Asp Asp Ile Leu Leu Trp Leu Gln Lys Leu Val 
    450                 455                 460                 


Ser Val Leu Gln Arg Val Gly Cys Pro Gly Asp His Leu Phe Leu Leu 
465                 470                 475                 480 


Asn His Ile Leu Arg Cys Pro Ala Gly Val Ser Lys Trp Ala Val Pro 
                485                 490                 495     


Phe Ile Gln Ile Lys Val Leu His Asn Pro Ser Gly Val Phe His Phe 
            500                 505                 510         


Met Gln Ser Leu Ala Leu Leu Met Ser Pro Val Lys Asn Arg Ala Glu 
        515                 520                 525             


Phe Met Cys His Met Lys Pro Ser Glu Arg Lys Pro Ser Ser Ser Gly 
    530                 535                 540                 


Pro Gly Ser Gly Thr Trp Thr Leu Val Asp Glu Gly Gly Glu Glu Asp 
545                 550                 555                 560 


Glu Asp Pro Glu Thr Ser Trp Ile Leu Leu Asn Glu Asp Asp Leu Val 
                565                 570                 575     


Thr Ile Leu Ala Gln Phe Pro Phe His Glu Leu Phe Gln His Leu Leu 
            580                 585                 590         


Gly Phe Lys Ala Lys Gly Asp Tyr Leu Pro Glu Thr Thr Arg Pro Gln 
        595                 600                 605             


Glu Met Met Lys Ile Phe Ala Phe Ala Asn Ser Leu Val Glu Leu Leu 
    610                 615                 620                 


Ala Val Gly Leu Glu Thr Phe Asn Arg Ala Arg Tyr Arg Gln Phe Val 
625                 630                 635                 640 


Lys Arg Ile Gly Tyr Met Ile Arg Met Thr Leu Gly Tyr Val Ser Asp 
                645                 650                 655     


His Trp Ala Gln Tyr Val Ser His Asn Gln Gly Ser Gly Leu Ala Gln 
            660                 665                 670         


Gln Pro Tyr Ser Met Glu Lys Leu Gln Val Glu Phe Asp Glu Leu Phe 
        675                 680                 685             


Leu Arg Ala Val Leu His Val Leu Lys Ala Lys Arg Leu Gly Ile Trp 
    690                 695                 700                 


Leu Phe Met Ser Glu Met Pro Phe Gly Thr Leu Ser Val Gln Met Leu 
705                 710                 715                 720 


Trp Lys Leu Phe Tyr Leu Met His Gln Val Glu Ser Glu Asn Leu Gln 
                725                 730                 735     


Gln Leu Ser Ser Ser Leu Gln Pro Ala Gln Cys Lys Gln Gln Leu Gln 
            740                 745                 750         


Asp Pro Glu His Phe Thr Asn Phe Glu Lys Cys Leu Ser Ser Met Asn 
        755                 760                 765             


Ser Ser Glu Glu Ile Cys Leu Leu Thr Thr Phe Ala Gln Met Ala Gln 
    770                 775                 780                 


Ala Arg Arg Thr Asn Val Asp Glu Asp Phe Ile Lys Ile Ile Val Leu 
785                 790                 795                 800 


Glu Ile Tyr Glu Val Ser Tyr Val Thr Leu Ser Thr Arg Glu Thr Phe 
                805                 810                 815     


Ser Lys Val Gly Arg Glu Leu Leu Gly Thr Ile Thr Ala Val His Pro 
            820                 825                 830         


Glu Ile Ile Ser Val Leu Leu Asp Arg Val Gln Glu Thr Ile Asp Gln 
        835                 840                 845             


Val Gly Met Val Ser Leu Tyr Leu Phe Lys Glu Leu Pro Leu Tyr Leu 
    850                 855                 860                 


Trp Gln Pro Ser Ala Ser Glu Ile Ala Val Ile Arg Asp Trp Leu Leu 
865                 870                 875                 880 


Asn Tyr Asn Leu Thr Val Val Lys Asn Lys Leu Ala Cys Val Ile Leu 
                885                 890                 895     


Glu Gly Leu Asn Trp Gly Phe Ala Lys Gln Ala Thr Leu His Leu Asp 
            900                 905                 910         


Gln Ala Val His Ala Glu Val Ala Leu Met Val Leu Glu Ala Tyr Gln 
        915                 920                 925             


Lys Tyr Leu Ala Gln Lys Pro Tyr Ala Gly Ile Leu Ser Glu Ser Met 
    930                 935                 940                 


Lys Gln Val Ser Tyr Leu Ala Ser Ile Val Arg Tyr Gly Glu Thr Pro 
945                 950                 955                 960 


Glu Thr Ser Phe Asn Gln Trp Ala Trp Asn Leu Ile Leu Arg Leu Lys 
                965                 970                 975     


Leu His Lys Asn Asp Tyr Gly Ile Gln Pro Asn Cys Pro Ala Val Pro 
            980                 985                 990         


Phe Ser Val Thr Val Pro Asp Met  Thr Glu Ser Pro Thr  Phe His Pro 
        995                 1000                 1005             


Leu Leu  Lys Ala Val Lys Ala  Gly Met Pro Ile Gly  Cys Tyr Leu 
    1010                 1015                 1020             


Ala Leu  Ser Met Thr Ala Val  Gly His Ser Ile Glu  Lys Phe Cys 
    1025                 1030                 1035             


Ala Glu  Gly Ile Pro Leu Leu  Gly Ile Leu Val Gln  Ser Arg His 
    1040                 1045                 1050             


Leu Arg  Thr Val Val His Val  Leu Asp Lys Ile Leu  Pro Leu Phe 
    1055                 1060                 1065             


Tyr Pro  Cys Gln Tyr Tyr Leu  Leu Lys Asn Glu Gln  Phe Leu Ser 
    1070                 1075                 1080             


His Leu  Leu Leu Phe Leu His  Leu Asp Ser Gly Val  Pro Gln Gly 
    1085                 1090                 1095             


Val Thr  Gln Gln Val Thr His  Lys Val Ala Gln His  Leu Thr Gly 
    1100                 1105                 1110             


Ala Ser  His Gly Asp Asn Val  Lys Leu Leu Asn Ser  Met Ile Gln 
    1115                 1120                 1125             


Ala His  Ile Ser Val Ser Thr  Gln Pro Asn Glu Val  Gly Pro Val 
    1130                 1135                 1140             


Ala Val  Leu Glu Phe Trp Val  Gln Ala Leu Ile Ser  Gln His Leu 
    1145                 1150                 1155             


Trp Tyr  Arg Glu Gln Pro Ile  Leu Phe Leu Met Asp  His Leu Cys 
    1160                 1165                 1170             


Lys Ala  Ala Phe Gln Leu Met  Gln Glu Asp Cys Ile  Gln Lys Leu 
    1175                 1180                 1185             


Leu Tyr  Gln Gln His Lys Asn  Ala Leu Gly Tyr His  Cys Asp Arg 
    1190                 1195                 1200             


Ser Leu  Leu Ser Ser Leu Val  Ser Trp Ile Val Ala  Gly Asn Ile 
    1205                 1210                 1215             


Thr Pro  Ser Phe Val Glu Gly  Leu Ala Thr Pro Thr  Gln Val Trp 
    1220                 1225                 1230             


Phe Ala  Trp Thr Val Leu Asn  Met Glu Ser Ile Phe  Glu Glu Asp 
    1235                 1240                 1245             


Ser Gln  Leu Arg Arg Val Ile  Glu Gly Glu Leu Val  Ile Asn Ser 
    1250                 1255                 1260             


Ala Phe  Thr Pro Asp Gln Ala  Leu Lys Lys Ala Gln  Thr Gln Leu 
    1265                 1270                 1275             


Lys Leu  Pro Ile Val Pro Ser  Leu Gln Arg Leu Leu  Ile Tyr Arg 
    1280                 1285                 1290             


Trp Ala  His Gln Ala Leu Val  Thr Pro Ser Asp His  Pro Leu Leu 
    1295                 1300                 1305             


Pro Leu  Ile Trp Gln Lys Phe  Phe Leu Leu Tyr Leu  His Arg Pro 
    1310                 1315                 1320             


Gly Pro  Gln Tyr Gly Leu Pro  Ile Asp Gly Cys Ile  Gly Arg Arg 
    1325                 1330                 1335             


Phe Phe  Gln Ser Pro Ala His  Ile Asn Leu Leu Lys  Glu Met Lys 
    1340                 1345                 1350             


Arg Arg  Leu Thr Glu Val Ala  Asp Phe His His Ala  Ala Ser Lys 
    1355                 1360                 1365             


Ala Leu  Arg Val Pro Ala Glu  Gly Ser Glu Gly Leu  Pro Glu Ser 
    1370                 1375                 1380             


His Ser  Gly Thr Pro Gly Tyr  Leu Thr Ser Pro Glu  Leu His Lys 
    1385                 1390                 1395             


Glu Leu  Val Arg Leu Phe Asn  Val Tyr Ile Leu Trp  Leu Glu Asp 
    1400                 1405                 1410             


Glu Asn  Phe Gln Lys Gly Asp  Thr Tyr Ile Pro Ser  Leu Pro Lys 
    1415                 1420                 1425             


His Tyr  Asp Ile His Arg Leu  Ala Lys Val Met Gln  Asn Gln Gln 
    1430                 1435                 1440             


Asp Leu  Trp Met Glu Tyr Leu  Asn Met Glu Arg Ile  Tyr His Glu 
    1445                 1450                 1455             


Phe Gln  Glu Thr Val Gly Leu  Trp Thr Gln Ala Lys  Leu Glu Ser 
    1460                 1465                 1470             


His Ser  Thr Pro Cys Ser Leu  Ser Val Gln Leu Asp  Phe Thr Asp 
    1475                 1480                 1485             


Pro Leu  Leu Ala Lys Glu Arg  Val Leu Ser Asn Leu  Arg Lys His 
    1490                 1495                 1500             


Glu Ala  Pro Gln Pro Pro Leu  Ala Leu His Pro Thr  Lys Pro Pro 
    1505                 1510                 1515             


Val Pro  Val Ile Ser Ser Ala  Val Leu Leu Ser Gln  Lys Asp Ala 
    1520                 1525                 1530             


Thr Gln  Leu Val Cys Thr Asp  Leu Asn Leu Leu Gln  Gln Gln Ala 
    1535                 1540                 1545             


Arg Thr  Ala Ala Leu Arg Glu  Ser Gln Gln Val Ala  Leu Asp Gly 
    1550                 1555                 1560             


Glu Leu  Leu Asp Thr Met Pro  Lys Gln Tyr Val Asn  Arg Glu Glu 
    1565                 1570                 1575             


Gln Thr  Thr Leu His Leu Glu  Cys Arg Gly Ser Ser  Gly Lys Lys 
    1580                 1585                 1590             


Cys Gln  Gly Ala Ala Val Val  Thr Val Gln Phe Glu  Gly Met His 
    1595                 1600                 1605             


Lys Asn  Glu Ala Ile Ser Gln  Gln Leu His Val Leu  Arg Lys Glu 
    1610                 1615                 1620             


Val Lys  Gln Leu Gln Ala Glu  Ala Ala Lys Pro Pro  Ser Leu Asn 
    1625                 1630                 1635             


Ile Val  Glu Ala Ala Val His  Ala Glu Asn Leu Ile  Thr Ala Leu 
    1640                 1645                 1650             


Val Asn  Ala Tyr Lys Leu Gln  Pro Thr Pro Gly Ile  Gln Lys Val 
    1655                 1660                 1665             


Gly Ile  Ser Leu Phe Phe Thr  Ile Val Asp Tyr Val  Ser Asp Glu 
    1670                 1675                 1680             


Thr Gln  Arg His Pro Pro Thr  Arg Gln Phe Phe Thr  Ser Cys Ile 
    1685                 1690                 1695             


Glu Ile  Leu Gly Gln Val Phe  Ile Ser Gly Ile Lys  Ser Glu Cys 
    1700                 1705                 1710             


Arg Lys  Val Leu Glu Thr Ile  Leu Lys Asn Ser Arg  Leu Cys Ser 
    1715                 1720                 1725             


Leu Leu  Ser Pro Phe Phe Thr  Pro Asn Ala Ala Pro  Ala Glu Phe 
    1730                 1735                 1740             


Ile Gln  Leu Tyr Glu Gln Val  Val Lys Phe Leu Ser  Glu Asp Asn 
    1745                 1750                 1755             


Ser Asp  Met Ile Phe Met Leu  Leu Thr Lys Phe Asp  Leu Lys Gln 
    1760                 1765                 1770             


Trp Leu  Ser Ala Thr Lys Pro  Pro Leu Ser Asp Arg  Thr Arg Leu 
    1775                 1780                 1785             


Leu Glu  Ser Ile His Leu Ala  Leu Thr Ala Trp Gly  Leu Glu Pro 
    1790                 1795                 1800             


Asp Glu  Asp Ile Leu Met Pro  Phe Asn Leu Phe Cys  Lys His Trp 
    1805                 1810                 1815             


Thr Tyr  Leu Leu Leu Tyr Gln  Phe Pro Asp Gln Tyr  Ser Asp Ile 
    1820                 1825                 1830             


Leu Arg  Leu Leu Met Gln Ser  Ser Ala Glu Gln Leu  Leu Ser Pro 
    1835                 1840                 1845             


Glu Cys  Trp Lys Ala Thr Leu  Arg Ala Leu Gly Cys  Cys Ala Pro 
    1850                 1855                 1860             


Ser Cys  Gln Gln Gly Ala Ala  Ser Thr Glu Gly Ala  Val Leu Pro 
    1865                 1870                 1875             


Ser Ser  Ser Asp Ala Leu Leu  Ser Asp Lys Gln Val  Met Glu Thr 
    1880                 1885                 1890             


Ile Gln  Trp Leu Ser Asp Phe  Phe Tyr Lys Leu Arg  Leu Ser Lys 
    1895                 1900                 1905             


Met Asp  Phe Lys Ser Phe Gly  Leu Phe Ser Lys Trp  Ser Pro Tyr 
    1910                 1915                 1920             


Met Ala  Asp Val Lys Thr Phe  Leu Gly Tyr Leu Val  Lys Arg Leu 
    1925                 1930                 1935             


Ile Asp  Leu Glu Met Thr Cys  Leu Ala Gln Asp Pro  Thr Ala Ser 
    1940                 1945                 1950             


Arg Lys  Thr Val Leu Lys Ser  Leu His Ser Val Ile  Ile Gln Leu 
    1955                 1960                 1965             


Phe Lys  Pro Trp Ile Leu Val  Leu Glu Asp Asn Glu  Ser Ser Gln 
    1970                 1975                 1980             


Gln Arg  His Tyr Pro Trp Leu  Glu Ser Asp Thr Val  Val Ala Ser 
    1985                 1990                 1995             


Ser Ile  Val Gln Leu Phe Thr  Asp Cys Ile Asp Ser  Leu His Glu 
    2000                 2005                 2010             


Ser Phe  Lys Asp Lys Leu Leu  Pro Gly Asp Ala Gly  Ala Leu Trp 
    2015                 2020                 2025             


Leu His  Leu Met His Tyr Cys  Glu Ala Cys Thr Ala  Pro Lys Met 
    2030                 2035                 2040             


Pro Glu  Phe Ile Leu Tyr Ala  Phe His Ser Thr Tyr  Arg Lys Leu 
    2045                 2050                 2055             


Pro Trp  Lys Asp Leu His Pro  Asp Gln Met Leu Met  Glu Ala Phe 
    2060                 2065                 2070             


Phe Lys  Val Glu Arg Gly Ser  Pro Lys Ser Cys Phe  Leu Phe Leu 
    2075                 2080                 2085             


Gly Ser  Val Leu Cys Glu Val  Asn Trp Val Ser Val  Leu Ser Asp 
    2090                 2095                 2100             


Ala Trp  Asn Ser Ser Pro His  Pro Glu Thr Arg Ser  Met Ile Val 
    2105                 2110                 2115             


Cys Leu  Leu Phe Met Met Ile  Leu Leu Ala Lys Glu  Val Gln Leu 
    2120                 2125                 2130             


Val Asp  Gln Thr Asp Ser Pro  Leu Leu Ser Leu Leu  Gly Gln Thr 
    2135                 2140                 2145             


Ser Ser  Leu Ser Trp His Leu  Val Asp Ile Val Ser  Tyr Gln Ser 
    2150                 2155                 2160             


Val Leu  Ser Tyr Phe Ser Ser  His Tyr Pro Pro Ser  Ile Ile Leu 
    2165                 2170                 2175             


Ala Lys  Glu Ser Tyr Ala Glu  Leu Ile Met Lys Leu  Leu Lys Val 
    2180                 2185                 2190             


Ser Ala  Gly Leu Ser Ile Pro  Thr Asp Ser Gln Lys  His Leu Asp 
    2195                 2200                 2205             


Ala Val  Pro Lys Cys Gln Ala  Phe Thr His Gln Met  Val Gln Phe 
    2210                 2215                 2220             


Leu Ser  Thr Leu Glu Gln Asn  Gly Lys Ile Thr Leu  Ala Val Leu 
    2225                 2230                 2235             


Glu Gln  Glu Met Ser Lys Leu  Leu Asp Asp Ile Ile  Val Phe Asn 
    2240                 2245                 2250             


Pro Pro  Asp Met Asp Ser Gln  Thr Arg His Met Ala  Leu Ser Ser 
    2255                 2260                 2265             


Leu Phe  Met Glu Val Leu Met  Met Met Asn Asn Ala  Thr Ile Pro 
    2270                 2275                 2280             


Thr Ala  Glu Phe Leu Arg Gly  Ser Ile Arg Thr Trp  Ile Gly Gln 
    2285                 2290                 2295             


Lys Met  His Gly Leu Val Val  Leu Pro Leu Leu Thr  Ala Ala Cys 
    2300                 2305                 2310             


Gln Ser  Leu Ala Ser Val Arg  His Met Ala Glu Thr  Thr Glu Ala 
    2315                 2320                 2325             


Cys Ile  Thr Ala Tyr Phe Lys  Glu Ser Pro Leu Asn  Gln Asn Ser 
    2330                 2335                 2340             


Gly Trp  Gly Pro Ile Leu Val  Ser Leu Gln Val Pro  Glu Leu Thr 
    2345                 2350                 2355             


Met Glu  Glu Phe Leu Gln Glu  Cys Leu Thr Leu Gly  Ser Tyr Leu 
    2360                 2365                 2370             


Thr Leu  Tyr Val Tyr Leu Leu  Gln Cys Leu Asn Ser  Glu Gln Thr 
    2375                 2380                 2385             


Leu Arg  Asn Glu Met Lys Val  Leu Leu Ile Leu Ser  Lys Trp Leu 
    2390                 2395                 2400             


Glu Gln  Val Tyr Pro Ser Ser  Val Glu Glu Glu Ala  Lys Leu Phe 
    2405                 2410                 2415             


Leu Trp  Trp His Gln Val Leu  Gln Leu Ser Leu Ile  Gln Thr Glu 
    2420                 2425                 2430             


Gln Asn  Asp Ser Val Leu Thr  Glu Ser Val Ile Arg  Ile Leu Leu 
    2435                 2440                 2445             


Leu Val  Gln Ser Arg Gln Asn  Leu Val Ala Glu Glu  Arg Leu Ser 
    2450                 2455                 2460             


Ser Gly  Ile Leu Gly Ala Ile  Gly Phe Gly Arg Lys  Ser Pro Leu 
    2465                 2470                 2475             


Ser Asn  Arg Phe Arg Val Val  Ala Arg Ser Met Ala  Ala Phe Leu 
    2480                 2485                 2490             


Ser Val  Gln Val Pro Met Glu  Asp Gln Ile Arg Leu  Arg Pro Gly 
    2495                 2500                 2505             


Ser Glu  Leu His Leu Thr Pro  Lys Ala Gln Gln Ala  Leu Asn Ala 
    2510                 2515                 2520             


Leu Glu  Ser Met Ala Ser Ser  Lys Gln Tyr Val Glu  Tyr Gln Asp 
    2525                 2530                 2535             


Gln Ile  Leu Gln Ala Thr Gln  Phe Ile Arg His Pro  Gly His Cys 
    2540                 2545                 2550             


Leu Gln  Asp Gly Lys Ser Phe  Leu Ala Leu Leu Val  Asn Cys Leu 
    2555                 2560                 2565             


Tyr Pro  Glu Val His Tyr Leu  Asp His Ile Arg 
    2570                 2575                 


<210>  123
<211>  2979
<212>  DNA
<213>  Homo sapiens

<400>  123
atggcccgcg gcggggcggc ctgcaagagc gacgcgcggc tgctgctggg gcgggacgcg       60

ctgcggccgg cgcccgccct gctggccccc gccgtgctgc tgggcgccgc gctcggcctc      120

ggcctcggcc tttggcttgg ctgccgcgcg ggccgccagc gcacgcgaca ccagaaagac      180

gacactcaaa atctgctcaa gaatttggag tctaatgcgc agaccccctc ggaaactggc      240

tccccatcaa ggaggaggaa gagagaagtg cagatgtcga aggacaagga agctgttgat      300

gaatgtgagc cgccttccaa cagcaatatc acagcattcg ccctgaaggc caaagtcatc      360

taccccatca atcagaagtt ccggcctctg gccgatggct cctccaaccc gtctctgcat      420

gaaaacttaa agcaggctgt tttgccacac cagccggtag aggcctctcc ttccagcagt      480

ctggggagcc tgagccaggg tgagaaggac gactgcagct cctcatccag cgtccactcg      540

gccaccagcg atgacaggtt tctcagccgc accttcctcc gggtgaacgc cttccctgaa      600

gtgctggcct gcgagagtgt agacgttgac ctgtgtatct acagccttca cttaaaagac      660

ctgctgcatt tggacacggc actgaggcag gaaaagcata tgatgtttat tcagattttt      720

aaaatgtgcc tccttgacct tcttcctaaa aagaagtcag atgatgaact ataccagaag      780

atcctttcaa aacaagaaaa agatttggag gaactagaaa agggacttca ggtcaaactg      840

tcaaacacag aaatgtcggg ggctggtgac tctgagtaca tcaccctggc tgatgtggaa      900

aagaaggaga gagaatactc tgaacagcta atcgataata tggaagcttt ctggaaacag      960

atggcaaata tccagcactt tcttgtggac cagtttaagt gttccagctc caaagcccga     1020

cagctgatga tgactctgac ggaaagaatg attgcagccg aagggctatt gtgcgattct     1080

caggagctgc aggctctgga cgccctggag aggacgatgg ggcgggcgca catggcaaaa     1140

gtgattgagt ttctgaagct gcaagtccag gaggagacca ggtgccggct ggctgccatc     1200

tcccacggcc tggagctgct ggctggtgag gggaagctgt ccgggcggca gaaggaggag     1260

ctgctcacgc agcagcacaa ggccttctgg caggaggcag agcgcttcag ccgggagttt     1320

gtccagcgag gcaaagacct ggtcacggcg tctctggctc accaggtgga gggaacggca     1380

aaactcacgc tggcccaaga ggaggaacag agaagcttcc tggctgaggc ccagccgact     1440

gctgacccgg aaaagtttct cgaggctttt catgaggtcc tggagaggca gaggctgatg     1500

cagtgtgacc tggaggaaga ggagaatgtc agagccaccg aggctgtggt tgcactctgc     1560

caggagctgt acttcagcac cgtggacact ttccagaagt tcgtggatgc cctgttcctt     1620

cagacgctcc ctggcatgac tggcctcccc ccggaagagt gtgactactt gaggcaggaa     1680

gtccaggaga acgctgcctg gcagctgggg aagtcaaatc gcttccggag gcagcagtgg     1740

aaactcttcc aggagctcct agagcaagac cagcaggtgt ggatggagga gtgtgcgctg     1800

tccagcgtgc tgcagacaca cctgcgggag gaccacgagg gcaccatccg cggcgtcttg     1860

ggccgactgg gcggcctcac tgaagagtcc acgcggtgtg tcctgcaggg gcatgacctg     1920

ctgttgcgct cagccctccg gaggctggca ctccgcggca acgccctggc caccctgacg     1980

cagatgcggc tatcggggaa gaagcacctc ctgcaggagc tgcgggaaca gcgtgcactg     2040

gagcaggggt cctcccagtg cctggacgag catcagtggc agctgctcag ggccctggag     2100

gcgcgtgtgc tggaggaggc cagccggcta gaggaggaag cacagcagac acggctgcag     2160

ctccagcagc ggctcctggc cgaggcccag gaggtggggc agcttctgca gcagcacatg     2220

gagtgcgcca ttgggcaggc gctgctggtg catgcacgga atgcagccac caagagccgg     2280

gccaaggaca gggatgactt caagaggaca ctgatggagg cggcagtgga gagcgtctac     2340

gtgaccagcg ctggtgtcag ccgcctggtg caggcgtatt accagcaaat cggaaggatc     2400

atggaggacc acgaggagag aaaactgcag cacctgaaga ccctgcaggg tgagaggatg     2460

gaaaattaca aactgcggaa aaagcaagaa ctcagcaacc cttcgtcggg cagcaggacg     2520

gcaggtggcg ctcatgagac ctcccaggcg gtccaccaga ggatgctgtc ccagcagaag     2580

aggttcctgg cccagttccc agtgcaccag cagatgcgtc tgcacgccca gcagcagcag     2640

gcaggagtca tggaccttct ggaagcccag ctggagaccc agctacagga agctgaacag     2700

aacttcatct ccgagctggc agccttggcc cgagtgcccc ttgctgaaag caaactgttg     2760

cctgctaagc gtgggctgct agagaagccc ctaaggacta aaaggaagaa gcccctgccc     2820

caggaaagag gggacctggg ggtgcccaac aatgaggacc ttgcctccgg ggaccagacc     2880

tcaggctcac tcagcagcaa aaggctgagt cagcaagaaa gtgaagctgg ggacagtggg     2940

aactcaaaga agatgctaaa gagaagaagc aacttgtag                            2979


<210>  124
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Arg Gly Gly Ala Ala Cys Lys Ser Asp Ala Arg Leu Leu Leu 
1               5                   10                  15      


Gly Arg Asp Ala Leu Arg Pro Ala Pro Ala Leu Leu Ala Pro Ala Val 
            20                  25                  30          


Leu Leu Gly Ala Ala Leu Gly Leu Gly Leu Gly Leu Trp Leu Gly Cys 
        35                  40                  45              


Arg Ala Gly Arg Gln Arg Thr Arg His Gln Lys Asp Asp Thr Gln Asn 
    50                  55                  60                  


Leu Leu Lys Asn Leu Glu Ser Asn Ala Gln Thr Pro Ser Glu Thr Gly 
65                  70                  75                  80  


Ser Pro Ser Arg Arg Arg Lys Arg Glu Val Gln Met Ser Lys Asp Lys 
                85                  90                  95      


Glu Ala Val Asp Glu Cys Glu Pro Pro Ser Asn Ser Asn Ile Thr Ala 
            100                 105                 110         


Phe Ala Leu Lys Ala Lys Val Ile Tyr Pro Ile Asn Gln Lys Phe Arg 
        115                 120                 125             


Pro Leu Ala Asp Gly Ser Ser Asn Pro Ser Leu His Glu Asn Leu Lys 
    130                 135                 140                 


Gln Ala Val Leu Pro His Gln Pro Val Glu Ala Ser Pro Ser Ser Ser 
145                 150                 155                 160 


Leu Gly Ser Leu Ser Gln Gly Glu Lys Asp Asp Cys Ser Ser Ser Ser 
                165                 170                 175     


Ser Val His Ser Ala Thr Ser Asp Asp Arg Phe Leu Ser Arg Thr Phe 
            180                 185                 190         


Leu Arg Val Asn Ala Phe Pro Glu Val Leu Ala Cys Glu Ser Val Asp 
        195                 200                 205             


Val Asp Leu Cys Ile Tyr Ser Leu His Leu Lys Asp Leu Leu His Leu 
    210                 215                 220                 


Asp Thr Ala Leu Arg Gln Glu Lys His Met Met Phe Ile Gln Ile Phe 
225                 230                 235                 240 


Lys Met Cys Leu Leu Asp Leu Leu Pro Lys Lys Lys Ser Asp Asp Glu 
                245                 250                 255     


Leu Tyr Gln Lys Ile Leu Ser Lys Gln Glu Lys Asp Leu Glu Glu Leu 
            260                 265                 270         


Glu Lys Gly Leu Gln Val Lys Leu Ser Asn Thr Glu Met Ser Gly Ala 
        275                 280                 285             


Gly Asp Ser Glu Tyr Ile Thr Leu Ala Asp Val Glu Lys Lys Glu Arg 
    290                 295                 300                 


Glu Tyr Ser Glu Gln Leu Ile Asp Asn Met Glu Ala Phe Trp Lys Gln 
305                 310                 315                 320 


Met Ala Asn Ile Gln His Phe Leu Val Asp Gln Phe Lys Cys Ser Ser 
                325                 330                 335     


Ser Lys Ala Arg Gln Leu Met Met Thr Leu Thr Glu Arg Met Ile Ala 
            340                 345                 350         


Ala Glu Gly Leu Leu Cys Asp Ser Gln Glu Leu Gln Ala Leu Asp Ala 
        355                 360                 365             


Leu Glu Arg Thr Met Gly Arg Ala His Met Ala Lys Val Ile Glu Phe 
    370                 375                 380                 


Leu Lys Leu Gln Val Gln Glu Glu Thr Arg Cys Arg Leu Ala Ala Ile 
385                 390                 395                 400 


Ser His Gly Leu Glu Leu Leu Ala Gly Glu Gly Lys Leu Ser Gly Arg 
                405                 410                 415     


Gln Lys Glu Glu Leu Leu Thr Gln Gln His Lys Ala Phe Trp Gln Glu 
            420                 425                 430         


Ala Glu Arg Phe Ser Arg Glu Phe Val Gln Arg Gly Lys Asp Leu Val 
        435                 440                 445             


Thr Ala Ser Leu Ala His Gln Val Glu Gly Thr Ala Lys Leu Thr Leu 
    450                 455                 460                 


Ala Gln Glu Glu Glu Gln Arg Ser Phe Leu Ala Glu Ala Gln Pro Thr 
465                 470                 475                 480 


Ala Asp Pro Glu Lys Phe Leu Glu Ala Phe His Glu Val Leu Glu Arg 
                485                 490                 495     


Gln Arg Leu Met Gln Cys Asp Leu Glu Glu Glu Glu Asn Val Arg Ala 
            500                 505                 510         


Thr Glu Ala Val Val Ala Leu Cys Gln Glu Leu Tyr Phe Ser Thr Val 
        515                 520                 525             


Asp Thr Phe Gln Lys Phe Val Asp Ala Leu Phe Leu Gln Thr Leu Pro 
    530                 535                 540                 


Gly Met Thr Gly Leu Pro Pro Glu Glu Cys Asp Tyr Leu Arg Gln Glu 
545                 550                 555                 560 


Val Gln Glu Asn Ala Ala Trp Gln Leu Gly Lys Ser Asn Arg Phe Arg 
                565                 570                 575     


Arg Gln Gln Trp Lys Leu Phe Gln Glu Leu Leu Glu Gln Asp Gln Gln 
            580                 585                 590         


Val Trp Met Glu Glu Cys Ala Leu Ser Ser Val Leu Gln Thr His Leu 
        595                 600                 605             


Arg Glu Asp His Glu Gly Thr Ile Arg Gly Val Leu Gly Arg Leu Gly 
    610                 615                 620                 


Gly Leu Thr Glu Glu Ser Thr Arg Cys Val Leu Gln Gly His Asp Leu 
625                 630                 635                 640 


Leu Leu Arg Ser Ala Leu Arg Arg Leu Ala Leu Arg Gly Asn Ala Leu 
                645                 650                 655     


Ala Thr Leu Thr Gln Met Arg Leu Ser Gly Lys Lys His Leu Leu Gln 
            660                 665                 670         


Glu Leu Arg Glu Gln Arg Ala Leu Glu Gln Gly Ser Ser Gln Cys Leu 
        675                 680                 685             


Asp Glu His Gln Trp Gln Leu Leu Arg Ala Leu Glu Ala Arg Val Leu 
    690                 695                 700                 


Glu Glu Ala Ser Arg Leu Glu Glu Glu Ala Gln Gln Thr Arg Leu Gln 
705                 710                 715                 720 


Leu Gln Gln Arg Leu Leu Ala Glu Ala Gln Glu Val Gly Gln Leu Leu 
                725                 730                 735     


Gln Gln His Met Glu Cys Ala Ile Gly Gln Ala Leu Leu Val His Ala 
            740                 745                 750         


Arg Asn Ala Ala Thr Lys Ser Arg Ala Lys Asp Arg Asp Asp Phe Lys 
        755                 760                 765             


Arg Thr Leu Met Glu Ala Ala Val Glu Ser Val Tyr Val Thr Ser Ala 
    770                 775                 780                 


Gly Val Ser Arg Leu Val Gln Ala Tyr Tyr Gln Gln Ile Gly Arg Ile 
785                 790                 795                 800 


Met Glu Asp His Glu Glu Arg Lys Leu Gln His Leu Lys Thr Leu Gln 
                805                 810                 815     


Gly Glu Arg Met Glu Asn Tyr Lys Leu Arg Lys Lys Gln Glu Leu Ser 
            820                 825                 830         


Asn Pro Ser Ser Gly Ser Arg Thr Ala Gly Gly Ala His Glu Thr Ser 
        835                 840                 845             


Gln Ala Val His Gln Arg Met Leu Ser Gln Gln Lys Arg Phe Leu Ala 
    850                 855                 860                 


Gln Phe Pro Val His Gln Gln Met Arg Leu His Ala Gln Gln Gln Gln 
865                 870                 875                 880 


Ala Gly Val Met Asp Leu Leu Glu Ala Gln Leu Glu Thr Gln Leu Gln 
                885                 890                 895     


Glu Ala Glu Gln Asn Phe Ile Ser Glu Leu Ala Ala Leu Ala Arg Val 
            900                 905                 910         


Pro Leu Ala Glu Ser Lys Leu Leu Pro Ala Lys Arg Gly Leu Leu Glu 
        915                 920                 925             


Lys Pro Leu Arg Thr Lys Arg Lys Lys Pro Leu Pro Gln Glu Arg Gly 
    930                 935                 940                 


Asp Leu Gly Val Pro Asn Asn Glu Asp Leu Ala Ser Gly Asp Gln Thr 
945                 950                 955                 960 


Ser Gly Ser Leu Ser Ser Lys Arg Leu Ser Gln Gln Glu Ser Glu Ala 
                965                 970                 975     


Gly Asp Ser Gly Asn Ser Lys Lys Met Leu Lys Arg Arg Ser Asn Leu 
            980                 985                 990         


<210>  125
<211>  3687
<212>  DNA
<213>  Homo sapiens

<400>  125
atgatttggc ccaaagtgga atgctgtcac tttaagactg cagtggaagc accacttgga       60

atgaaattgg acaagaaaat ggaagtcttc atcccactct caacttctgc agcctctagt      120

gggccatggg ctcattcctt atttgctttt ataccctcct ggcctaagaa gaacttattt      180

aaaagagagt ctcctataac acaccgcctg tatggggaca tttcaagaga agttcaaggg      240

acttctgaaa atggagtaat ttttcagaaa tgtgcactgg tgtctgggtc gagtgaagca      300

cagacagccc gcatatggct gcttgttaac aacaccaaga caacctcgtc agccaacctc      360

tcggagctgc tcttgctgga cagcattgct ggtctcacca tttgggactc tgtgggaaac      420

aggacctcgg aaggattcca ggcttttagc aagaagtttc tgcaagtggg agatgccttt      480

gctgtcagct acgcagccac gctccaggct ggagacctcg ggaacgggga gagcctcaag      540

cttcctgccc aactcacctt tcagagctcg tcacggaaca gaacacagct gaaagtgctt      600

ttttccataa cagcagaaga aaacgtaacg gttctgccgc accacggcct ccacgcagca      660

gggttcttca ttgccttcct cctctccctt gtgctgacct gggctgccct cttcctcatg      720

gttcgctatc agtgtctgaa gggaaacatg ctcaccagac atcgggtttg gcagtatgag      780

agcaagctgg aacccttgcc gttcacctca gctgatggcg tgaatgagga cctttccctt      840

aacgaccaaa tgatagacat tctgtcttcc gaggaccctg ggagcatgct tcaagcctta      900

gaagagttgg agattgcaac cctgaatcgg gcagatgcag atctggaggc ttgtcgaaca      960

caaatcagca aggatatcat tgcccttctg ctgaaaaatc tcaccagcag tggccacctc     1020

tcaccccaag tagagagaaa aatgagtgct gttttcaaaa agcagtttct attgctggaa     1080

aatgaaatac aagaggagta cgatcggaag atggtggcat tgacagctga atgtgacctg     1140

gaaacaagaa agaagatgga aaaccagtac cagagagaga tgatggcaat ggaggaagca     1200

gaagagttgc tgaaacgtgc tggtgagagg tctgctgtag agtgcagcaa ccttctgcgg     1260

accctccatg gcctggaaca ggagcacttg aggaagtctc tcgctttgca acaagaagaa     1320

gactttgcca aagctcacag acagctggct gttttccaga gaaatgaact gcacagtatc     1380

ttttttaccc agataaaaag tgctattttc aaaggggaat tgaaaccaga ggcagctaaa     1440

atgctgctgc aaaattattc taaaatacag gagaatgtag aagagttaat ggactttttc     1500

caggctagta agaggtatca tctaagtaaa agatttggcc acagggaata tctggtccag     1560

aacctccagt catcagagac ccgtgtgcag ggccttctga gcaccgctgc agcccagctg     1620

actcacctca ttcagaagca cgagagagca gggtacctgg atgaagacca aatggaaatg     1680

ctattggagc gggctcagac agaagtcttt tcaatcaagc agaagttgga caatgactta     1740

aagcaggaaa agaaaaagct ccaccaaaaa ttaataacta agagaagacg agagttgcta     1800

caaaagcaca gggagcagcg tagggagcag gcgtccgtcg gcgaggcctt ccgaacggtt     1860

gaggatgccg gccagtacct gcaccagaag aggagcctga tggaggagca cggtgccacc     1920

ctggaggagc tgcaggagcg tctggaccag gccgccctgg acgatctcag gaccctgacc     1980

ctttcgctgt ttgaaaaggc caccgacgag ctgcggcgcc tgcagaactc agccatgacc     2040

caggagctgc tcaagcgtgg ggtgccctgg ctcttcctgc agcagatcct ggaggagcac     2100

ggcaaggaga tggctgcacg ggccgagcag ctggaggggg aggagaggga cagggaccag     2160

gagggtgtcc agagcgtgag gcagagactg aaggatgacg ctcctgaggc cgtgacagag     2220

gagcaggcag agctgcgacg ctgggagcac ctgatcttca tgaagctctg ctcctcagtc     2280

ttctccctgt ctgaagagga gctgctcagg atgaggcagg aggtccatgg ctgctttgct     2340

cagatggaca ggagcttggc cctccccaag atccgggccc gagttctgct gcagcaattt     2400

cagactgcgt ggcgagaagc agagttcgtg aagctggacc aggccgtggc tgcccctgag     2460

ctgcagcaac agtccaaggt gagaaagtca cggtccaaga gtaaaagcaa gggagagctt     2520

ctgaagaagt gcatcgaaga caaaattcac ctctgtgagg aacaggcctc tgaagacctg     2580

gtggaaaagg ttcgaggtga attgctgcgg gagagagtgc agcggatgga ggcacaggag     2640

ggaggctttg cacagtcgct tgttgctctg cagttccaga aggcgtcccg ggtgaccgag     2700

actctgtcgg cctacaccgc cctcctcagc atccaggact tgctcctgga agagctgagt     2760

gcatctgaga tgctgaccaa gtcggcctgc acacagatcc tggagtcgca cagccgggag     2820

ctccaggagt tggagaggaa gctggaggac cagctggtgc agcaggaggc agcccagcag     2880

cagcaggccc tggcgagctg gcagcagtgg gtggccgatg ggcccgggat tctgaacgaa     2940

cctggggagg tggattctga aaggcaggtc tctactgtcc tgcaccaagc cctgagcaag     3000

agccagacat tactggagca acatcagcag tgtttgagag aggaacaaca gaacagtgtc     3060

gtgctagaag acttgttgga aaacatggag gcagacacct ttgcaaccct gtgcagccag     3120

gagctgagac tggcatcgta cctggcgagg atggccatgg tgcccggggc cacgcttcgc     3180

cggctcctga gtgtggtact gcccacagcc tcacagcctc agctgctggc cctgctggat     3240

tcggccaccg agagacatgt ggaccacgca gctgagagcg atggcggagc ggagcaggcc     3300

gacgtgggca ggcggaggaa acaccagagc tggtggcaag ccttagatgg caaactgcga     3360

ggagatctga taagcagagg attagaaaag atgctgtggg cccgcaagag aaagcagagc     3420

atattaaaga agacatgtct ccctctcaga gagaggatga tattctctgg aaaaggaagt     3480

tggccacacc tgtcactgga gcccattggc gaactggccc ctgtacccat tgtaggggca     3540

gaaaccattg atctattaaa cacaggagag aagctcttta tattcagaaa tccaaaggag     3600

ccagagatct cactgcacgt tcctcccagg aaaaagaaga actttttgaa tgccaaaaag     3660

gccatgaggg ccttgggcat ggactag                                         3687


<210>  126
<211>  1228
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ile Trp Pro Lys Val Glu Cys Cys His Phe Lys Thr Ala Val Glu 
1               5                   10                  15      


Ala Pro Leu Gly Met Lys Leu Asp Lys Lys Met Glu Val Phe Ile Pro 
            20                  25                  30          


Leu Ser Thr Ser Ala Ala Ser Ser Gly Pro Trp Ala His Ser Leu Phe 
        35                  40                  45              


Ala Phe Ile Pro Ser Trp Pro Lys Lys Asn Leu Phe Lys Arg Glu Ser 
    50                  55                  60                  


Pro Ile Thr His Arg Leu Tyr Gly Asp Ile Ser Arg Glu Val Gln Gly 
65                  70                  75                  80  


Thr Ser Glu Asn Gly Val Ile Phe Gln Lys Cys Ala Leu Val Ser Gly 
                85                  90                  95      


Ser Ser Glu Ala Gln Thr Ala Arg Ile Trp Leu Leu Val Asn Asn Thr 
            100                 105                 110         


Lys Thr Thr Ser Ser Ala Asn Leu Ser Glu Leu Leu Leu Leu Asp Ser 
        115                 120                 125             


Ile Ala Gly Leu Thr Ile Trp Asp Ser Val Gly Asn Arg Thr Ser Glu 
    130                 135                 140                 


Gly Phe Gln Ala Phe Ser Lys Lys Phe Leu Gln Val Gly Asp Ala Phe 
145                 150                 155                 160 


Ala Val Ser Tyr Ala Ala Thr Leu Gln Ala Gly Asp Leu Gly Asn Gly 
                165                 170                 175     


Glu Ser Leu Lys Leu Pro Ala Gln Leu Thr Phe Gln Ser Ser Ser Arg 
            180                 185                 190         


Asn Arg Thr Gln Leu Lys Val Leu Phe Ser Ile Thr Ala Glu Glu Asn 
        195                 200                 205             


Val Thr Val Leu Pro His His Gly Leu His Ala Ala Gly Phe Phe Ile 
    210                 215                 220                 


Ala Phe Leu Leu Ser Leu Val Leu Thr Trp Ala Ala Leu Phe Leu Met 
225                 230                 235                 240 


Val Arg Tyr Gln Cys Leu Lys Gly Asn Met Leu Thr Arg His Arg Val 
                245                 250                 255     


Trp Gln Tyr Glu Ser Lys Leu Glu Pro Leu Pro Phe Thr Ser Ala Asp 
            260                 265                 270         


Gly Val Asn Glu Asp Leu Ser Leu Asn Asp Gln Met Ile Asp Ile Leu 
        275                 280                 285             


Ser Ser Glu Asp Pro Gly Ser Met Leu Gln Ala Leu Glu Glu Leu Glu 
    290                 295                 300                 


Ile Ala Thr Leu Asn Arg Ala Asp Ala Asp Leu Glu Ala Cys Arg Thr 
305                 310                 315                 320 


Gln Ile Ser Lys Asp Ile Ile Ala Leu Leu Leu Lys Asn Leu Thr Ser 
                325                 330                 335     


Ser Gly His Leu Ser Pro Gln Val Glu Arg Lys Met Ser Ala Val Phe 
            340                 345                 350         


Lys Lys Gln Phe Leu Leu Leu Glu Asn Glu Ile Gln Glu Glu Tyr Asp 
        355                 360                 365             


Arg Lys Met Val Ala Leu Thr Ala Glu Cys Asp Leu Glu Thr Arg Lys 
    370                 375                 380                 


Lys Met Glu Asn Gln Tyr Gln Arg Glu Met Met Ala Met Glu Glu Ala 
385                 390                 395                 400 


Glu Glu Leu Leu Lys Arg Ala Gly Glu Arg Ser Ala Val Glu Cys Ser 
                405                 410                 415     


Asn Leu Leu Arg Thr Leu His Gly Leu Glu Gln Glu His Leu Arg Lys 
            420                 425                 430         


Ser Leu Ala Leu Gln Gln Glu Glu Asp Phe Ala Lys Ala His Arg Gln 
        435                 440                 445             


Leu Ala Val Phe Gln Arg Asn Glu Leu His Ser Ile Phe Phe Thr Gln 
    450                 455                 460                 


Ile Lys Ser Ala Ile Phe Lys Gly Glu Leu Lys Pro Glu Ala Ala Lys 
465                 470                 475                 480 


Met Leu Leu Gln Asn Tyr Ser Lys Ile Gln Glu Asn Val Glu Glu Leu 
                485                 490                 495     


Met Asp Phe Phe Gln Ala Ser Lys Arg Tyr His Leu Ser Lys Arg Phe 
            500                 505                 510         


Gly His Arg Glu Tyr Leu Val Gln Asn Leu Gln Ser Ser Glu Thr Arg 
        515                 520                 525             


Val Gln Gly Leu Leu Ser Thr Ala Ala Ala Gln Leu Thr His Leu Ile 
    530                 535                 540                 


Gln Lys His Glu Arg Ala Gly Tyr Leu Asp Glu Asp Gln Met Glu Met 
545                 550                 555                 560 


Leu Leu Glu Arg Ala Gln Thr Glu Val Phe Ser Ile Lys Gln Lys Leu 
                565                 570                 575     


Asp Asn Asp Leu Lys Gln Glu Lys Lys Lys Leu His Gln Lys Leu Ile 
            580                 585                 590         


Thr Lys Arg Arg Arg Glu Leu Leu Gln Lys His Arg Glu Gln Arg Arg 
        595                 600                 605             


Glu Gln Ala Ser Val Gly Glu Ala Phe Arg Thr Val Glu Asp Ala Gly 
    610                 615                 620                 


Gln Tyr Leu His Gln Lys Arg Ser Leu Met Glu Glu His Gly Ala Thr 
625                 630                 635                 640 


Leu Glu Glu Leu Gln Glu Arg Leu Asp Gln Ala Ala Leu Asp Asp Leu 
                645                 650                 655     


Arg Thr Leu Thr Leu Ser Leu Phe Glu Lys Ala Thr Asp Glu Leu Arg 
            660                 665                 670         


Arg Leu Gln Asn Ser Ala Met Thr Gln Glu Leu Leu Lys Arg Gly Val 
        675                 680                 685             


Pro Trp Leu Phe Leu Gln Gln Ile Leu Glu Glu His Gly Lys Glu Met 
    690                 695                 700                 


Ala Ala Arg Ala Glu Gln Leu Glu Gly Glu Glu Arg Asp Arg Asp Gln 
705                 710                 715                 720 


Glu Gly Val Gln Ser Val Arg Gln Arg Leu Lys Asp Asp Ala Pro Glu 
                725                 730                 735     


Ala Val Thr Glu Glu Gln Ala Glu Leu Arg Arg Trp Glu His Leu Ile 
            740                 745                 750         


Phe Met Lys Leu Cys Ser Ser Val Phe Ser Leu Ser Glu Glu Glu Leu 
        755                 760                 765             


Leu Arg Met Arg Gln Glu Val His Gly Cys Phe Ala Gln Met Asp Arg 
    770                 775                 780                 


Ser Leu Ala Leu Pro Lys Ile Arg Ala Arg Val Leu Leu Gln Gln Phe 
785                 790                 795                 800 


Gln Thr Ala Trp Arg Glu Ala Glu Phe Val Lys Leu Asp Gln Ala Val 
                805                 810                 815     


Ala Ala Pro Glu Leu Gln Gln Gln Ser Lys Val Arg Lys Ser Arg Ser 
            820                 825                 830         


Lys Ser Lys Ser Lys Gly Glu Leu Leu Lys Lys Cys Ile Glu Asp Lys 
        835                 840                 845             


Ile His Leu Cys Glu Glu Gln Ala Ser Glu Asp Leu Val Glu Lys Val 
    850                 855                 860                 


Arg Gly Glu Leu Leu Arg Glu Arg Val Gln Arg Met Glu Ala Gln Glu 
865                 870                 875                 880 


Gly Gly Phe Ala Gln Ser Leu Val Ala Leu Gln Phe Gln Lys Ala Ser 
                885                 890                 895     


Arg Val Thr Glu Thr Leu Ser Ala Tyr Thr Ala Leu Leu Ser Ile Gln 
            900                 905                 910         


Asp Leu Leu Leu Glu Glu Leu Ser Ala Ser Glu Met Leu Thr Lys Ser 
        915                 920                 925             


Ala Cys Thr Gln Ile Leu Glu Ser His Ser Arg Glu Leu Gln Glu Leu 
    930                 935                 940                 


Glu Arg Lys Leu Glu Asp Gln Leu Val Gln Gln Glu Ala Ala Gln Gln 
945                 950                 955                 960 


Gln Gln Ala Leu Ala Ser Trp Gln Gln Trp Val Ala Asp Gly Pro Gly 
                965                 970                 975     


Ile Leu Asn Glu Pro Gly Glu Val Asp Ser Glu Arg Gln Val Ser Thr 
            980                 985                 990         


Val Leu His Gln Ala Leu Ser Lys  Ser Gln Thr Leu Leu  Glu Gln His 
        995                 1000                 1005             


Gln Gln  Cys Leu Arg Glu Glu  Gln Gln Asn Ser Val  Val Leu Glu 
    1010                 1015                 1020             


Asp Leu  Leu Glu Asn Met Glu  Ala Asp Thr Phe Ala  Thr Leu Cys 
    1025                 1030                 1035             


Ser Gln  Glu Leu Arg Leu Ala  Ser Tyr Leu Ala Arg  Met Ala Met 
    1040                 1045                 1050             


Val Pro  Gly Ala Thr Leu Arg  Arg Leu Leu Ser Val  Val Leu Pro 
    1055                 1060                 1065             


Thr Ala  Ser Gln Pro Gln Leu  Leu Ala Leu Leu Asp  Ser Ala Thr 
    1070                 1075                 1080             


Glu Arg  His Val Asp His Ala  Ala Glu Ser Asp Gly  Gly Ala Glu 
    1085                 1090                 1095             


Gln Ala  Asp Val Gly Arg Arg  Arg Lys His Gln Ser  Trp Trp Gln 
    1100                 1105                 1110             


Ala Leu  Asp Gly Lys Leu Arg  Gly Asp Leu Ile Ser  Arg Gly Leu 
    1115                 1120                 1125             


Glu Lys  Met Leu Trp Ala Arg  Lys Arg Lys Gln Ser  Ile Leu Lys 
    1130                 1135                 1140             


Lys Thr  Cys Leu Pro Leu Arg  Glu Arg Met Ile Phe  Ser Gly Lys 
    1145                 1150                 1155             


Gly Ser  Trp Pro His Leu Ser  Leu Glu Pro Ile Gly  Glu Leu Ala 
    1160                 1165                 1170             


Pro Val  Pro Ile Val Gly Ala  Glu Thr Ile Asp Leu  Leu Asn Thr 
    1175                 1180                 1185             


Gly Glu  Lys Leu Phe Ile Phe  Arg Asn Pro Lys Glu  Pro Glu Ile 
    1190                 1195                 1200             


Ser Leu  His Val Pro Pro Arg  Lys Lys Lys Asn Phe  Leu Asn Ala 
    1205                 1210                 1215             


Lys Lys  Ala Met Arg Ala Leu  Gly Met Asp 
    1220                 1225             


<210>  127
<211>  8616
<212>  DNA
<213>  Homo sapiens

<400>  127
atgcgtcgag ggcgtctgct ggagatcgcc ctgggattta ccgtgctttt agcgtcctac       60

acgagccatg gggcggacgc caatttggag gctgggaacg tgaaggaaac cagagccagt      120

cgggccaaga gaagaggcgg tggaggacac gacgcgctta aaggacccaa tgtctgtgga      180

tcacgttata atgcttactg ttgccctgga tggaaaacct tacctggcgg aaatcagtgt      240

attgtcccca tttgccggca ttcctgtggg gatggatttt gttcgaggcc aaatatgtgc      300

acttgcccat ctggtcagat agctccttcc tgtggctcca gatccataca acactgcaat      360

attcgctgta tgaatggagg tagctgcagt gacgatcact gtctatgcca gaaaggatac      420

atagggactc actgtggaca acctgtttgt gaaagtggct gtctcaatgg aggaaggtgt      480

gtggccccaa atcgatgtgc atgcacttac ggatttactg gaccccagtg tgaaagagat      540

tacaggacag gcccatgttt tactgtgatc agcaaccaga tgtgccaggg acaactcagc      600

gggattgtct gcacaaaaac gctctgctgt gccacagtcg gccgagcctg gggccacccc      660

tgtgagatgt gtcctgccca gcctcacccc tgccgccgtg gcttcattcc aaatatccgc      720

acgggagctt gtcaagatgt ggatgaatgc caggccatcc ccgggctctg tcagggagga      780

aattgcatta atactgttgg gtcttttgag tgcaaatgcc ctgctggaca caaacttaat      840

gaagtgtcac aaaaatgtga agatattgat gaatgcagca ccattcctgg aatctgtgaa      900

gggggtgaat gtacaaacac agtcagcagt tacttttgca aatgtccccc tggtttttac      960

acctctccag atggtaccag atgcatagat gttcgcccag gatactgtta cacagctctg     1020

acaaacgggc gctgctctaa ccagctgcca cagtccataa ccaaaatgca gtgctgctgt     1080

gatgccggcc gatgctggtc tccaggggtc actgtcgccc ctgagatgtg tcccatcaga     1140

gcaaccgagg atttcaacaa gctgtgctct gttcctatgg taattcctgg gagaccagaa     1200

tatcctcccc caccccttgg ccccattcct ccagttctcc ctgttcctcc tggctttcct     1260

cctggacctc aaattccggt ccctcgacca ccagtggaat atctgtatcc atctcgggag     1320

ccaccaaggg tgctgccagt aaacgttact gattactgcc agttggtccg ctatctctgt     1380

caaaatggac gctgcattcc aactcctggg agttaccggt gtgagtgcaa caaagggttc     1440

cagctggacc tccgtgggga gtgtattgat gttgatgaat gtgagaaaaa cccctgtgct     1500

ggtggtgagt gtattaacaa ccagggttcg tacacctgtc agtgccgagc tggatatcag     1560

agcacactca cgcggacaga atgccgagac attgatgagt gtttacagaa tggccggatc     1620

tgcaataatg gacgctgcat caacacagat ggcagttttc attgcgtgtg taatgcgggc     1680

tttcatgtta cacgagatgg gaagaactgt gaagatatgg atgaatgcag cataaggaac     1740

atgtgcctta atggaatgtg tatcaatgaa gatggcagtt ttaaatgtat ttgcaaacct     1800

ggattccagc tggcatcaga tggacgttat tgcaaagaca ttaacgagtg tgaaacccct     1860

gggatctgca tgaatgggcg ttgcgtcaac actgatggct cctacagatg tgaatgcttc     1920

cctggactgg ctgtgggtct ggatggccgt gtgtgtgttg acacacacat gcggagcaca     1980

tgctatggtg gatacaagag aggccagtgt atcaaacctt tgtttggtgc tgtcactaaa     2040

tctgaatgct gttgcgccag cactgagtat gcatttgggg aaccttgcca gccgtgtcct     2100

gcacagaatt cagcggaata tcaggcactc tgcagcagtg ggccaggaat gacgtcagca     2160

ggcagtgata taaatgaatg tgcactagat cctgatattt gcccaaatgg aatctgtgaa     2220

aaccttcgtg ggacctataa atgtatatgc aattcaggat atgaagtgga ttcaactggg     2280

aaaaactgcg ttgatattaa tgaatgtgta ctgaacagtc tcctttgtga caatggacaa     2340

tgtagaaata ctcctggaag ttttgtctgt acctgcccca agggatttat ctacaaacct     2400

gatctaaaaa catgtgaaga cattgatgaa tgcgaatcaa gtccttgcat taatggagtc     2460

tgcaagaaca gcccaggctc ttttatttgt gaatgttctt ctgaaagtac tttggatcca     2520

acaaaaacca tctgcataga aaccatcaag ggcacttgct ggcagactgt cattgatggg     2580

cgatgtgaga tcaacatcaa tggagccacc ttaaagtccc agtgctgctc ctccctcggt     2640

gctgcgtggg gaagcccgtg caccctatgc caagttgatc ccatatgtgg taaagggtac     2700

tcaagaatta aaggaacaca atgtgaagat atagatgaat gtgaagtgtt cccaggagtg     2760

tgtaaaaatg gcctgtgtgt taacactagg gggtcattca agtgtcagtg tcccagtgga     2820

atgactttgg atgccacagg aaggatctgt cttgatatcc gcctggaaac ctgcttcctg     2880

aggtacgagg acgaggagtg caccctgcct attgctggcc gccaccgcat ggacgcctgc     2940

tgctgctccg tcggggcagc ctggggtact gaggaatgcg aggagtgtcc catgagaaat     3000

actcctgagt acgaggagct gtgtccgaga ggacccggat ttgccacaaa agaaattaca     3060

aatggaaagc ctttcttcaa agatatcaat gagtgcaaga tgatacccag cctctgcacc     3120

cacggcaagt gcagaaacac cattggcagc tttaagtgca ggtgtgacag cggctttgct     3180

cttgattctg aagaaaggaa ctgcacagac attgacgaat gccgcatatc tcctgacctc     3240

tgtggcagag gccagtgtgt gaacacccct ggggactttg aatgcaagtg tgacgaaggc     3300

tatgaaagtg gattcatgat gatgaagaac tgcatggata ttgatgagtg tcagagagat     3360

cctctcctat gccgaggtgg tgtttgccat aacacagagg gaagttaccg ctgtgaatgc     3420

ccgcctggcc atcagctgtc ccccaacatc tccgcgtgta tcgacatcaa tgaatgtgag     3480

ctgagtgcac acctgtgccc caatggccgt tgcgtgaacc tcatagggaa gtatcagtgt     3540

gcctgcaacc ctggctacca ttcaactccc gataggctat tttgtgttga cattgatgaa     3600

tgcagcataa tgaatggtgg ttgtgaaacc ttctgcacaa actctgaagg cagctatgaa     3660

tgtagctgtc agccgggatt tgcactaatg cctgaccaga gatcatgcac cgacatcgat     3720

gagtgtgaag ataatcccaa tatctgtgat ggtggtcagt gcacaaatat ccctggagag     3780

tacaggtgct tgtgttatga tggattcatg gcatctgaag acatgaagac ttgtgtagat     3840

gtcaatgagt gtgacctgaa tccaaatatc tgcctaagtg ggacctgtga aaacacgaaa     3900

ggctcattta tctgccactg tgatatgggc tactccggca aaaaaggaaa aactggctgt     3960

acagacatca atgaatgtga aattggagca cacaactgtg gcaaacatgc tgtatgtacc     4020

aatacagcag gaagcttcaa atgtagctgc agtcccgggt ggattggaga tggcattaag     4080

tgcactgatc tggacgaatg ttccaatgga acccatatgt gcagccagca tgcagactgc     4140

aagaatacca tgggatctta ccgctgtctg tgcaaggaag gatacacagg tgatggcttc     4200

acttgtacag accttgatga gtgctctgag aacctgaatc tctgtggcaa tggccagtgc     4260

ctcaatgcac caggaggata ccgctgtgaa tgcgacatgg gcttcgtgcc cagtgctgac     4320

gggaaagcct gtgaagatat tgatgagtgc tcccttccga acatctgtgt ctttggaact     4380

tgccacaacc tccctggcct gttccgctgt gagtgtgaga taggctacga actggacaga     4440

agcggcggga actgcacaga tgtgaatgaa tgcctggatc caaccacgtg catcagtggg     4500

aactgtgtca acactccagg cagctatatc tgtgactgcc cacctgattt tgaactgaac     4560

ccaactcgag ttggctgtgt tgatacccgc tctggaaatt gctatttgga tattcgacct     4620

cgaggagaca atggagatac agcctgcagc aatgaaattg gagttggtgt ttccaaagct     4680

tcctgctgct gttctctggg taaagcctgg ggtactcctt gtgagatgtg tcctgctgtg     4740

aacacatccg agtacaaaat tctttgtcct ggaggggaag gtttccgacc aaatcctatc     4800

accgttatat tggaagatat tgatgagtgc caggagctac cagggctgtg ccaaggagga     4860

aaatgtatca acacctttgg gagtttccag tgccgctgtc caaccggcta ctacctgaat     4920

gaagatacac gagtgtgtga tgatgtgaat gaatgtgaga ctcctggaat ctgtggtcca     4980

gggacatgtt acaacaccgt tggcaactac acctgtatct gtcctccaga ctacatgcaa     5040

gtgaatgggg gaaataattg catggatatg agaagaagtt tgtgctacag aaactactat     5100

gctgacaacc agacctgtga tggagaattg ttattcaaca tgaccaagaa gatgtgctgc     5160

tgttcctaca acattggccg ggcgtggaac aagccctgtg aacagtgtcc catcccaagt     5220

acagatgagt ttgctacact ctgtggaagt caaaggccag gctttgtcat cgacatttat     5280

accggtttac ccgttgatat tgatgagtgc cgggagatcc caggggtctg tgaaaatgga     5340

gtgtgtatca acatggttgg cagcttccga tgtgaatgtc cagtgggatt cttctataat     5400

gacaagttgt tggtttgtga agatattgac gagtgtcaga acggcccagt gtgccagcgc     5460

aacgccgaat gcatcaacac tgcaggcagc taccgctgtg actgtaagcc cggctaccgc     5520

ttcacctcca caggacagtg caatgatcgt aatgaatgtc aagaaatccc caatatatgc     5580

agtcatgggc agtgcattga cacagttgga agcttttatt gcctttgcca cactggtttt     5640

aaaacaaatg atgaccaaac catgtgcttg gacataaatg aatgtgaaag agatgcctgt     5700

gggaatggaa cttgccggaa cacaattggt tccttcaact gccgctgcaa tcatggtttc     5760

atcctttctc acaacaatga ctgtatagat gttgatgaat gtgcaagtgg aaatgggaat     5820

ctttgcagaa atggccaatg cattaataca gtggggtctt tccagtgcca gtgcaatgaa     5880

ggctatgagg tggctccaga tgggaggacc tgtgtggata tcaatgaatg tcttctagaa     5940

cccagaaaat gtgcaccagg tacctgtcaa aacttggatg ggtcctacag atgcatttgc     6000

ccacctggat acagtcttca aaatgagaag tgtgaagata ttgatgagtg tgtcgaagag     6060

ccagaaattt gtgccctggg cacatgcagt aacactgaag gcagcttcaa atgtctgtgt     6120

ccagaagggt tttccttgtc ctccagtgga agaaggtgcc aagatttgcg aatgagctac     6180

tgttatgcga agtttgaagg aggaaagtgt tcatcaccca aatccagaaa tcactccaag     6240

caggaatgct gctgtgcctt gaagggagaa ggctggggag acccctgcga gctctgcccc     6300

acggaacctg atgaggcctt ccgccagata tgtccttatg gaagtgggat catcgtggga     6360

cctgatgatt cagcagttga tatggacgaa tgcaaagaac ccgatgtctg taaacatgga     6420

cagtgcatca atacagatgg ttcctatcgc tgcgagtgtc cctttggtta tattctagca     6480

gggaatgaat gtgtagatac tgatgaatgt tctgttggca atccttgtgg aaatggaacc     6540

tgcaagaatg tgattggagg ttttgaatgc acctgcgagg agggatttga gcccggtcca     6600

atgatgacat gtgaagatat aaatgaatgt gcccagaatc ctctgctctg tgccttccga     6660

tgtgtgaaca cttatgggtc atatgaatgc aaatgtcccg tgggatatgt gctcagagaa     6720

gaccgtagga tgtgcaaaga tgaggatgag tgtgaagagg gaaaacatga ctgtactgaa     6780

aaacaaatgg aatgcaagaa cctcattggc acatatatgt gcatctgtgg acccgggtat     6840

cagcggagac ctgatggaga aggctgtgta gatgagaatg aatgtcagac gaagccaggg     6900

atctgtgaga atgggcgctg cctcaacacc cgtgggagct acacctgtga gtgtaatgat     6960

gggtttaccg ccagccccaa ccaggacgag tgccttgaca atcgggaagg gtactgcttc     7020

acagaggtgc tacaaaacat gtgtcagatc ggctccagca acaggaaccc cgtcaccaaa     7080

tcggaatgct gctgtgacgg agggagaggc tggggtcccc actgtgagat ctgccctttc     7140

caggggactg tggctttcaa gaaactctgt ccccatggcc gaggattcat gaccaatgga     7200

gcagatatcg atgaatgcaa ggttattcac gatgtttgcc gaaatgggga atgtgtcaat     7260

gacagaggat catatcattg catttgtaaa actgggtaca ctccagatat aactgggact     7320

tcctgtgtag atctgaacga gtgcaaccag gctcccaaac cctgcaattt tatctgcaaa     7380

aacacagaag ggagttacca gtgttcatgc ccgaaaggct acattctgca agaggatgga     7440

aggagctgca aagatcttga tgagtgtgca accaagcaac acaactgcca gttcctatgt     7500

gttaacacca ttggcggctt cacatgcaaa tgtcctcccg gatttaccca acaccatacg     7560

tcctgcattg ataacaatga atgcacctct gacatcaatc tgtgcgggtc taagggcatt     7620

tgccagaaca ctcctggaag cttcacctgt gaatgccagc ggggattctc acttgatcag     7680

accggctcca gctgtgaaga cgtggacgag tgtgagggta accaccgctg ccagcatggc     7740

tgccagaaca tcattggggg ctacaggtgc agctgccccc agggctacct ccagcactac     7800

cagtggaacc agtgtgttga tgaaaacgaa tgcctcagcg ctcacatctg cggaggagcc     7860

tcctgtcaca acaccctggg gagctacaag tgcatgtgtc ccgccggctt ccagtatgaa     7920

cagttcagtg gaggatgcca agacatcaat gaatgtggct ctgcgcaggc cccctgcagc     7980

tatggctgtt ccaataccga gggcggttac ctgtgtggct gtccacctgg ttacttccgc     8040

ataggccaag ggcactgtgt ttctggaatg ggcatgggcc gaggaaaccc agagccacct     8100

gtcagtggtg aaatggatga caattcactc tccccagagg cttgttacga gtgtaagatc     8160

aatggctacc ccaaacgggg caggaaacgg agaagcacaa acgaaactga tgcctccaat     8220

atcgaggatc agtctgagac agaagccaat gtgagtcttg caagttggga tgttgagaag     8280

acagccatct ttgctttcaa tatttcccac gtcagtaaca aggttcgaat cctagaactc     8340

cttccagctc ttacaactct gacgaatcac aacagatact tgatcgaatc tggaaatgaa     8400

gatggcttct ttaaaatcaa ccaaaaggaa gggatcagct acctccactt cacaaagaag     8460

aagccagtgg ctggaaccta ttcattacaa atcagtagta ctccacttta taaaaagaaa     8520

gaacttaacc aactagaaga caaatatgac aaagactacc tcagtggtga actgggtgat     8580

aatctgaaga tgaaaatcca ggttttgctt cattaa                               8616


<210>  128
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Tyr Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  129
<211>  8520
<212>  DNA
<213>  Homo sapiens

<400>  129
atggccgcgc acaggccggt ggaatgggtc caggccgtgg tcagccgctt cgacgagcag       60

cttccaataa aaacaggaca gcagaacaca cataccaaag tcagtactga gcacaacaag      120

gaatgtctaa tcaatatttc caaatacaag ttttctttgg ttataagcgg cctcactact      180

attttaaaga atgttaacaa tatgagaata tttggagaag ctgctgaaaa aaatttatat      240

ctctctcagt tgattatatt ggatacactg gaaaaatgtc ttgctgggca accaaaggac      300

acaatgagat tagatgaaac gatgctggtc aaacagttgc tgccagaaat ctgccatttt      360

cttcacacct gtcgtgaagg aaaccagcat gcagctgaac ttcggaattc tgcctctggg      420

gttttatttt ctctcagctg caacaacttc aatgcagtct ttagtcgcat ttctaccagg      480

ttacaggaat taactgtttg ttcagaagac aatgttgatg ttcatgatat agaattgtta      540

cagtatatca atgtggattg tgcaaaatta aaacgactcc tgaaggaaac agcatttaaa      600

tttaaagccc taaagaaggt tgcgcagtta gcagttataa atagcctgga aaaggcattt      660

tggaactggg tagaaaatta tccagatgaa tttacaaaac tataccagat cccacagact      720

gatatggctg aatgtgcaga aaagctattt gacttggtgg atggttttgc tgaaagcacc      780

aaacgtaaag cagcagtttg gccactacaa atcattctcc ttatcttgtg tccagaaata      840

atccaggata tatccaaaga cgtggttgat gaaaacaaca tgaataagaa gttatttctg      900

gacagtctac gaaaagctct tgctggccat ggaggaagta ggcagctgac agaaagtgct      960

gcaattgcct gtgtcaaact gtgtaaagca agtacttaca tcaattggga agataactct     1020

gtcattttcc tacttgttca gtccatggtg gttgatctta agaacctgct ttttaatcca     1080

agtaagccat tctcaagagg cagtcagcct gcagatgtgg atctaatgat tgactgcctt     1140

gtttcttgct ttcgtataag ccctcacaac aaccaacact ttaagatctg cctggctcag     1200

aattcacctt ctacatttca ctatgtgctg gtaaattcac tccatcgaat catcaccaat     1260

tccgcattgg attggtggcc taagattgat gctgtgtatt gtcactcggt tgaacttcga     1320

aatatgtttg gtgaaacact tcataaagca gtgcaaggtt gtggagcaca cccagcaata     1380

cgaatggcac cgagtcttac atttaaagaa aaagtaacaa gccttaaatt taaagaaaaa     1440

cctacagacc tggagacaag aagctataag tatcttctct tgtccatggt gaaactaatt     1500

catgcagatc caaagctctt gctttgtaat ccaagaaaac aggggcccga aacccaaggc     1560

agtacagcag aattaattac agggctcgtc caactggtcc ctcagtcaca catgccagag     1620

attgctcagg aagcaatgga ggctctgctg gttcttcatc agttagatag cattgatttg     1680

tggaatcctg atgctcctgt agaaacattt tgggagatta gctcacaaat gcttttttac     1740

atctgcaaga aattaactag tcatcaaatg cttagtagca cagaaattct caagtggttg     1800

cgggaaatat tgatctgcag gaataaattt cttcttaaaa ataagcaggc agatagaagt     1860

tcctgtcact ttctcctttt ttacggggta ggatgtgata ttccttctag tggaaatacc     1920

agtcaaatgt ccatggatca tgaagaatta ctacgtactc ctggagcctc tctccggaag     1980

ggaaaaggga actcctctat ggatagtgca gcaggatgca gcggaacccc cccgatttgc     2040

cgacaagccc agaccaaact agaagtggcc ctgtacatgt ttctgtggaa ccctgacact     2100

gaagctgttc tggttgccat gtcctgtttc cgccacctct gtgaggaagc agatatccgg     2160

tgtggggtgg atgaagtgtc agtgcataac ctcttgccca actataacac attcatggag     2220

tttgcctctg tcagcaatat gatgtcaaca ggaagagcag cacttcagaa aagagtgatg     2280

gcactgctga ggcgcattga gcatcccact gcaggaaaca ctgaggcttg ggaagataca     2340

catgcaaaat gggaacaagc aacaaagcta atccttaact atccaaaagc caaaatggaa     2400

gatggccagg ctgctgaaag ccttcacaag accattgtta agaggcgaat gtcccatgtg     2460

agtggaggag gatccataga tttgtctgac acagactccc tacaggaatg gatcaacatg     2520

actggcttcc tttgtgccct tgggggagtg tgcctccagc agagaagcaa ttctggcctg     2580

gcaacctata gcccacccat gggtccagtc agtgaacgta agggttctat gatttcagtg     2640

atgtcttcag agggaaacgc agatacacct gtcagcaaat ttatggatcg gctgttgtcc     2700

ttaatggtgt gtaaccatga gaaagtggga cttcaaatac ggaccaatgt taaggatctg     2760

gtgggtctag aattgagtcc tgctctgtat ccaatgctat ttaacaaatt gaagaatacc     2820

atcagcaagt tttttgactc ccaaggacag gttttattga ctgataccaa tactcaattt     2880

gtagaacaaa ccatagctat aatgaagaac ttgctagata atcatactga aggcagctct     2940

gaacatctag ggcaagctag cattgaaaca atgatgttaa atctggtcag gtatgttcgt     3000

gtgcttggga atatggtcca tgcaattcaa ataaaaacga aactgtgtca attagttgaa     3060

gtaatgatgg caaggagaga tgacctctca ttttgccaag agatgaaatt taggaataag     3120

atggtagaat acctgacaga ctgggttatg ggaacatcaa accaagcagc agatgatgat     3180

gtaaaatgtc ttacaagaga tttggaccag gcaagcatgg aagcagtagt ttcacttcta     3240

gctggtctcc ctctgcagcc tgaagaagga gatggtgtgg aattgatgga agccaaatca     3300

cagttatttc ttaaatactt cacattattt atgaaccttt tgaatgactg cagtgaagtt     3360

gaagatgaaa gtgcgcaaac aggtggcagg aaacgtggca tgtctcggag gctggcatca     3420

ctgaggcact gtacggtcct tgcaatgtca aacttactca atgccaacgt agacagtggt     3480

ctcatgcact ccataggctt aggttaccac aaggatctcc agacaagagc tacatttatg     3540

gaagttctga caaaaatcct tcaacaaggc acagaatttg acacacttgc agaaacagta     3600

ttggctgatc ggtttgagag attggtggaa ctggtcacaa tgatgggtga tcaaggagaa     3660

ctccctatag cgatggctct ggccaatgtg gttccttgtt ctcagtggga tgaactagct     3720

cgagttctgg ttactctgtt tgattctcgg catttactct accaactgct ctggaacatg     3780

ttttctaaag aagtagaatt ggcagactcc atgcagactc tcttccgagg caacagcttg     3840

gccagtaaaa taatgacatt ctgtttcaag gtatatggtg ctacctatct acaaaaactc     3900

ctggatcctt tattacgaat tgtgatcaca tcctctgatt ggcaacatgt tagctttgaa     3960

gtggatccta ccaggttaga accatcagag agccttgagg aaaaccagcg gaacctcctt     4020

cagatgactg aaaagttctt ccatgccatc atcagttcct cctcagaatt cccccctcaa     4080

cttcgaagtg tgtgccactg tttataccag gcaacttgcc actccctact gaataaagct     4140

acagtaaaag aaaaaaagga aaacaaaaaa tcagtggtta gccagcgttt ccctcagaac     4200

agcatcggtg cagtaggaag tgccatgttc ctcagattta tcaatcctgc cattgtctca     4260

ccgtatgaag cagggatttt agataaaaag ccaccaccta gaatcgaaag gggcttgaag     4320

ttaatgtcaa agatacttca gagtattgcc aatcatgttc tcttcacaaa agaagaacat     4380

atgcggcctt tcaatgattt tgtgaaaagc aactttgatg cagcacgcag gtttttcctt     4440

gatatagcat ctgattgtcc tacaagtgat gcagtaaatc atagtctttc cttcataagt     4500

gacggcaatg tgcttgcttt acatcgtcta ctctggaaca atcaggagaa aattgggcag     4560

tatctttcca gcaacaggga tcataaagct gttggaagac gaccttttga taagatggca     4620

acacttcttg catacctggg tcctccagag cacaaacctg tggcagatac acactggtcc     4680

agccttaacc ttaccagttc aaagtttgag gaatttatga ctaggcatca ggtacatgaa     4740

aaagaagaat tcaaggcttt gaaaacgtta agtattttct accaagctgg gacttccaaa     4800

gctgggaatc ctatttttta ttatgttgca cggaggttca aaactggtca aatcaatggt     4860

gatttgctga tataccatgt cttactgact ttaaagccat attatgcaaa gccatatgaa     4920

attgtagtgg accttaccca taccgggcct agcaatcgct ttaaaacaga ctttctctct     4980

aagtggtttg ttgtttttcc tggctttgct tacgacaacg tctccgcagt ctatatctat     5040

aactgtaact cctgggtcag ggagtacacc aagtatcatg agcggctgct gactggcctc     5100

aaaggtagca aaaggcttgt tttcatagac tgtcctggga aactggctga gcacatagag     5160

catgaacaac agaaactacc tgctgccacc ttggctttag aagaggacct gaaggtattc     5220

cacaatgctc tcaagctagc tcacaaagac accaaagttt ccattaaagt tggttctact     5280

gctgtccaag taacttcagc agagcgaaca aaagtcctag ggcaatcagt ctttctaaat     5340

gacatttatt atgcttcgga aattgaagaa atctgcctag tagatgagaa ccagttcacc     5400

ttaaccattg caaaccaggg cacgccgctc accttcatgc accaggagtg tgaagccatt     5460

gtccagtcta tcattcatat ccggacccgc tgggaactgt cacagcccga ctctatcccc     5520

caacacacca agattcggcc aaaagatgtc cctgggacac tgctcaatat cgcattactt     5580

aatttaggca gttctgaccc gagtttacgg tcagctgcct ataatcttct gtgtgcctta     5640

acttgtacct ttaatttaaa aatcgagggc cagttactag agacatcagg tttatgtatc     5700

cctgccaaca acaccctctt tattgtctct attagtaaga cactggcagc caatgagcca     5760

cacctcacgt tagaattttt ggaagagtgt atttctggat ttagcaaatc tagtattgaa     5820

ttgaaacacc tttgtttgga atacatgact ccatggctgt caaatctagt tcgtttttgc     5880

aagcataatg atgatgccaa acgacaaaga gttactgcta ttcttgacaa gctgataaca     5940

atgaccatca atgaaaaaca gatgtaccca tctattcaag caaaaatatg gggaagcctt     6000

gggcagatta cagatctgct tgatgttgta ctagacagtt tcatcaaaac cagtgcaaca     6060

ggtggcttgg gatcaataaa agctgaggtg atggcagata ctgctgtagc tttggcttct     6120

ggaaatgtga aattggtttc aagcaaggtt attggaagga tgtgcaaaat aattgacaag     6180

acatgcttat ctccaactcc tactttagaa caacatctta tgtgggatga tattgctatt     6240

ttagcacgct acatgctgat gctgtccttc aacaattccc ttgatgtggc agctcatctt     6300

ccctacctct tccacgttgt tactttctta gtagccacag gtccgctctc ccttagagct     6360

tccacacatg gactggtcat taatatcatt cactctctgt gtacttgttc acagcttcat     6420

tttagtgaag agaccaagca agttttgaga ctcagtctga cagagttctc attacccaaa     6480

ttttacttgc tgtttggcat tagcaaagtc aagtcagctg ctgtcattgc cttccgttcc     6540

agttaccggg acaggtcatt ctctcctggc tcctatgaga gagagacttt tgctttgaca     6600

tccttggaaa cagtcacaga agctttgttg gagatcatgg aggcatgcat gagagatatt     6660

ccaacgtgca agtggctgga ccagtggaca gaactagctc aaagatttgc attccaatat     6720

aatccatccc tgcaaccaag agctcttgtt gtctttgggt gtattagcaa acgagtgtct     6780

catgggcaga taaagcagat aatccgtatt cttagcaagg cacttgagag ttgcttaaaa     6840

ggacctgaca cttacaacag tcaagttctg atagaagcta cagtaatagc actaaccaaa     6900

ttacagccac ttcttaataa ggactcgcct ctgcacaaag ccctcttttg ggtagctgtg     6960

gctgtgctgc agcttgatga ggtcaacttg tattcagcag gtaccgcact tcttgaacaa     7020

aacctgcata ctttagatag tctccgtata ttcaatgaca agagtccaga ggaagtattt     7080

atggcaatcc ggaatcctct ggagtggcac tgcaagcaaa tggatcattt tgttggactc     7140

aatttcaact ctaactttaa ctttgcattg gttggacacc ttttaaaagg gtacaggcat     7200

ccttcacctg ctattgttgc aagaacagtc agaattttac atacactact aactctggtt     7260

aacaaacaca gaaattgtga caaatttgaa gtgaatacac agagcgtggc ctacttagca     7320

gctttactta cagtgtctga agaagttcga agtcgctgca gcctaaaaca tagaaagtca     7380

cttcttctta ctgatatttc aatggaaaat gttcctatgg atacatatcc cattcatcat     7440

ggtgaccctt cctataggac actaaaggag actcagccat ggtcctctcc caaaggttct     7500

gaaggatacc ttgcagccac ctatccaact gtcggccaga ccagtccccg agccaggaaa     7560

tccatgagcc tggacatggg gcaaccttct caggccaaca ctaagaagtt gcttggaaca     7620

aggaaaagtt ttgatcactt gatatcagac acaaaggctc ctaaaaggca agaaatggaa     7680

tcagggatca caacaccccc caaaatgagg agagtagcag aaactgatta tgaaatggaa     7740

actcagagga tttcctcatc acaacagcac ccacatttac gtaaagtttc agtgtctgaa     7800

tcaaatgttc tcttggatga agaagtactt actgatccga agatccaggc gctgcttctt     7860

actgttctag ctacactggt aaaatatacc acagatgagt ttgatcaacg aattctttat     7920

gaatacttag cagaggccag tgttgtgttt cccaaagtct ttcctgttgt gcataatttg     7980

ttggactcta agatcaacac cctgttatca ttgtgccaag atccaaattt gttaaatcca     8040

atccatggaa ttgtgcagag tgtggtgtac catgaagaat ccccaccaca ataccaaaca     8100

tcttacctgc aaagttttgg ttttaatggc ttgtggcggt ttgcaggacc gttttcaaag     8160

caaacacaaa ttccagacta tgctgagctt attgttaagt ttcttgatgc cttgattgac     8220

acgtacctgc ctggaattga tgaagaaacc agtgaagaat ccctcctgac tcccacatct     8280

ccttaccctc ctgcactgca gagccagctt agtatcactg ccaaccttaa cctttctaat     8340

tccatgacct cacttgcaac ttcccagcat tccccaggaa tcgacaagga gaacgttgaa     8400

ctctccccta ccactggcca ctgtaacagt ggacgaactc gccacggatc cgcaagccaa     8460

gtgcagaagc aaagaagcgc tggcagtttc aaacgtaata gcattaagaa gatcgtgtga     8520


<210>  130
<211>  2839
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210>  131
<211>  6051
<212>  DNA
<213>  Homo sapiens

<400>  131
atggcaaact tcctattacc tcggggcacc agcagcttcc gcaggttcac acgggagtcc       60

ctggcagcca tcgagaagcg catggcagag aagcaagccc gcggctcaac caccttgcag      120

gagagccgag aggggctgcc cgaggaggag gctccccggc cccagctgga cctgcaggcc      180

tccaaaaagc tgccagatct ctatggcaat ccaccccaag agctcatcgg agagcccctg      240

gaggacctgg accccttcta tagcacccaa aagactttca tcgtactgaa taaaggcaag      300

accatcttcc ggttcagtgc caccaacgcc ttgtatgtcc tcagtccctt ccaccccatc      360

cggagagcgg ctgtgaagat tctggttcac tcgctcttca acatgctcat catgtgcacc      420

atcctcacca actgcgtgtt catggcccag cacgaccctc caccctggac caagtatgtc      480

gagtacacct tcaccgccat ttacaccttt gagtctctgg tcaagattct ggctcgaggc      540

ttctgcctgc acgcgttcac tttccttcgg gacccatgga actggctgga ctttagtgtg      600

attatcatgg catacacaac tgaatttgtg gacctgggca atgtctcagc cttacgcacc      660

ttccgagtcc tccgggccct gaaaactata tcagtcattt cagggctgaa gaccatcgtg      720

ggggccctga tccagtctgt gaagaagctg gctgatgtga tggtcctcac agtcttctgc      780

ctcagcgtct ttgccctcat cggcctgcag ctcttcatgg gcaacctaag gcacaagtgc      840

gtgcgcaact tcacagcgct caacggcacc aacggctccg tggaggccga cggcttggtc      900

tgggaatccc tggaccttta cctcagtgat ccagaaaatt acctgctcaa gaacggcacc      960

tctgatgtgt tactgtgtgg gaacagctct gacgctggga catgtccgga gggctaccgg     1020

tgcctaaagg caggcgagaa ccccgaccac ggctacacca gcttcgattc ctttgcctgg     1080

gcctttcttg cactcttccg cctgatgacg caggactgct gggagcgcct ctatcagcag     1140

accctcaggt ccgcagggaa gatctacatg atcttcttca tgcttgtcat cttcctgggg     1200

tccttctacc tggtgaacct gatcctggcc gtggtcgcaa tggcctatga ggagcaaaac     1260

caagccacca tcgctgagac cgaggagaag gaaaagcgct tccaggaggc catggaaatg     1320

ctcaagaaag aacacgaggc cctcaccatc aggggtgtgg ataccgtgtc ccgtagctcc     1380

ttggagatgt cccctttggc cccagtaaac agccatgaga gaagaagcaa gaggagaaaa     1440

cggatgtctt caggaactga ggagtgtggg gaggacaggc tccccaagtc tgactcagaa     1500

gatggtccca gagcaatgaa tcatctcagc ctcacccgtg gcctcagcag gacttctatg     1560

aagccacgtt ccagccgcgg gagcattttc acctttcgca ggcgagacct gggttctgaa     1620

gcagattttg cagatgatga aaacagcaca gcgggggaga gcgagagcca ccacacatca     1680

ctgctggtgc cctggcccct gcgccggacc agtgcccagg gacagcccag tcccggaacc     1740

tcggctcctg gccacgccct ccatggcaaa aagaacagca ctgtggactg caatggggtg     1800

gtctcattac tgggggcagg cgacccagag gccacatccc caggaagcca cctcctccgc     1860

cctgtgatgc tagagcaccc gccagacacg accacgccat cggaggagcc aggcgggccc     1920

cagatgctga cctcccaggc tccgtgtgta gatggcttcg aggagccagg agcacggcag     1980

cgggccctca gcgcagtcag cgtcctcacc agcgcactgg aagagttaga ggagtctcgc     2040

cacaagtgtc caccatgctg gaaccgtctc gcccagcgct acctgatctg ggagtgctgc     2100

ccgctgtgga tgtccatcaa gcagggagtg aagttggtgg tcatggaccc gtttactgac     2160

ctcaccatca ctatgtgcat cgtactcaac acactcttca tggcgctgga gcactacaac     2220

atgacaagtg aattcgagga gatgctgcag gtcggaaacc tggtcttcac agggattttc     2280

acagcagaga tgaccttcaa gatcattgcc ctcgacccct actactactt ccaacagggc     2340

tggaacatct tcgacagcat catcgtcatc cttagcctca tggagctggg cctgtcccgc     2400

atgagcaact tgtcggtgct gcgctccttc cgcctgctgc gggtcttcaa gctggccaaa     2460

tcatggccca ccctgaacac actcatcaag atcatcggga actcagtggg ggcactgggg     2520

aacctgacac tggtgctagc catcatcgtg ttcatctttg ctgtggtggg catgcagctc     2580

tttggcaaga actactcgga gctgagggac agcgactcag gcctgctgcc tcgctggcac     2640

atgatggact tctttcatgc cttcctcatc atcttccgca tcctctgtgg agagtggatc     2700

gagaccatgt gggactgcat ggaggtgtcg gggcagtcat tatgcctgct ggtcttcttg     2760

cttgttatgg tcattggcaa ccttgtggtc ctgaatctct tcctggcctt gctgctcagc     2820

tccttcagtg cagacaacct cacagcccct gatgaggaca gagagatgaa caacctccag     2880

ctggccctgg cccgcatcca gaggggcctg cgctttgtca agcggaccac ctgggatttc     2940

tgctgtggtc tcctgcggca gcggcctcag aagcccgcag cccttgccgc ccagggccag     3000

ctgcccagct gcattgccac cccctactcc ccgccacccc cagagacgga gaaggtgcct     3060

cccacccgca aggaaacacg gtttgaggaa ggcgagcaac caggccaggg cacccccggg     3120

gatccagagc ccgtgtgtgt gcccatcgct gtggccgagt cagacacaga tgaccaagaa     3180

gaagatgagg agaacagcct gggcacggag gaggagtcca gcaagcagca ggaatcccag     3240

cctgtgtccg gtggcccaga ggcccctccg gattccagga cctggagcca ggtgtcagcg     3300

actgcctcct ctgaggccga ggccagtgca tctcaggccg actggcggca gcagtggaaa     3360

gcggaacccc aggccccagg gtgcggtgag accccagagg acagttgctc cgagggcagc     3420

acagcagaca tgaccaacac cgctgagctc ctggagcaga tccctgacct cggccaggat     3480

gtcaaggacc cagaggactg cttcactgaa ggctgtgtcc ggcgctgtcc ctgctgtgcg     3540

gtggacacca cacaggcccc agggaaggtc tggtggcggt tgcgcaagac ctgctaccac     3600

atcgtggagc acagctggtt cgagacattc atcatcttca tgatcctact cagcagtgga     3660

gcgctggcct tcgaggacat ctacctagag gagcggaaga ccatcaaggt tctgcttgag     3720

tatgccgaca agatgttcac atatgtcttc gtgctggaga tgctgctcaa gtgggtggcc     3780

tacggcttca agaagtactt caccaatgcc tggtgctggc tcgacttcct catcgtagac     3840

gtctctctgg tcagcctggt ggccaacacc ctgggctttg ccgagatggg ccccatcaag     3900

tcactgcgga cgctgcgtgc actccgtcct ctgagagctc tgtcacgatt tgagggcatg     3960

agggtggtgg tcaatgccct ggtgggcgcc atcccgtcca tcatgaacgt cctcctcgtc     4020

tgcctcatct tctggctcat cttcagcatc atgggcgtga acctctttgc ggggaagttt     4080

gggaggtgca tcaaccagac agagggagac ttgcctttga actacaccat cgtgaacaac     4140

aagagccagt gtgagtcctt gaacttgacc ggagaattgt actggaccaa ggtgaaagtc     4200

aactttgaca acgtgggggc cgggtacctg gcccttctgc aggtggcaac atttaaaggc     4260

tggatggaca ttatgtatgc agctgtggac tccagggggt atgaagagca gcctcagtgg     4320

gaatacaacc tctacatgta catctatttt gtcattttca tcatctttgg gtctttcttc     4380

accctgaacc tctttattgg tgtcatcatt gacaacttca accaacagaa gaaaaagtta     4440

gggggccagg acatcttcat gacagaggag cagaagaagt actacaatgc catgaagaag     4500

ctgggctcca agaagcccca gaagcccatc ccacggcccc tgaacaagta ccagggcttc     4560

atattcgaca ttgtgaccaa gcaggccttt gacgtcacca tcatgtttct gatctgcttg     4620

aatatggtga ccatgatggt ggagacagat gaccaaagtc ctgagaaaat caacatcttg     4680

gccaagatca acctgctctt tgtggccatc ttcacaggcg agtgtattgt caagctggct     4740

gccctgcgcc actactactt caccaacagc tggaatatct tcgacttcgt ggttgtcatc     4800

ctctccatcg tgggcactgt gctctcggac atcatccaga agtacttctt ctccccgacg     4860

ctcttccgag tcatccgcct ggcccgaata ggccgcatcc tcagactgat ccgaggggcc     4920

aaggggatcc gcacgctgct ctttgccctc atgatgtccc tgcctgccct cttcaacatc     4980

gggctgctgc tcttcctcgt catgttcatc tactccatct ttggcatggc caacttcgct     5040

tatgtcaagt gggaggctgg catcgacgac atgttcaact tccagacctt cgccaacagc     5100

atgctgtgcc tcttccagat caccacgtcg gccggctggg atggcctcct cagccccatc     5160

ctcaacactg ggccgcccta ctgcgacccc actctgccca acagcaatgg ctctcggggg     5220

gactgcggga gcccagccgt gggcatcctc ttcttcacca cctacatcat catctccttc     5280

ctcatcgtgg tcaacatgta cattgccatc atcctggaga acttcagcgt ggccacggag     5340

gagagcaccg agcccctgag tgaggacgac ttcgatatgt tctatgagat ctgggagaaa     5400

tttgacccag aggccactca gtttattgag tattcggtcc tgtctgactt tgccgatgcc     5460

ctgtctgagc cactccgtat cgccaagccc aaccagataa gcctcatcaa catggacctg     5520

cccatggtga gtggggaccg catccattgc atggacattc tctttgcctt caccaaaagg     5580

gtcctggggg agtctgggga gatggacgcc ctgaagatcc agatggagga gaagttcatg     5640

gcagccaacc catccaagat ctcctacgag cccatcacca ccacactccg gcgcaagcac     5700

gaagaggtgt cggccatggt tatccagaga gccttccgca ggcacctgct gcaacgctct     5760

ttgaagcatg cctccttcct cttccgtcag caggcgggca gcggcctctc cgaagaggat     5820

gcccctgagc gagagggcct catcgcctac gtgatgagtg agaacttctc ccgacccctt     5880

ggcccaccct ccagctcctc catctcctcc acttccttcc caccctccta tgacagtgtc     5940

actagagcca ccagcgataa cctccaggtg cgggggtctg actacagcca cagtgaagat     6000

ctcgccgact tccccccttc tccggacagg gaccgtgagt ccatcgtgtg a              6051


<210>  132
<211>  2016
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210>  133
<211>  4002
<212>  DNA
<213>  Homo sapiens

<400>  133
atgcaggcgc agcagctgcc ctacgagttt ttcagcgaag agaacgcgcc caagtggcgg       60

ggactactgg tgcctgcgct gaaaaaggtc caggggcaag ttcatcctac tctcgagtct      120

aatgatgatg ctcttcagta tgttgaagaa ttaattttgc aattattaaa tatgctatgc      180

caagctcagc cccgaagtgc ttcagatgta gaggaacgtg ttcaaaaaag tttccctcat      240

ccaattgata aatgggcaat agctgatgcc caatcagcta ttgaaaagag gaagcgaaga      300

aaccctttat ctctcccagt agaaaaaatt catcctttat taaaggaggt cctaggttat      360

aaaattgacc accaggtttc tgtttacata gtagcagtct tagaatacat ttctgcagac      420

attttaaagc tggttgggaa ttatgtaaga aatatacggc attatgaaat tacaaaacaa      480

gatattaaag tggcaatgtg tgctgacaag gtattgatgg atatgtttca tcaagatgta      540

gaagatatta atatattatc tttaactgac gaagagcctt ccacctcagg agaacaaact      600

tactatgatt tggtaaaagc atttatggca gaaattcgac aatatataag ggaactaaat      660

ctaattataa aagtttttag agagcccttt gtctccaatt caaaattgtt ttcagctaat      720

gatgtagaaa atatatttag tcgcatagta gatatacatg aacttagtgt aaagttactg      780

ggccatatag aagatacagt agaaatgaca gatgaaggca gtccccatcc actagtagga      840

agctgctttg aagacttagc agaggaactg gcatttgatc catatgaatc gtatgctcga      900

gatattttgc gacctggttt tcatgatcgt ttccttagtc agttatcaaa gcctggggca      960

gcactttatt tgcagtcaat aggcgaaggt ttcaaagaag ctgttcaata tgttttaccc     1020

aggctgcttc tggcccctgt ttaccactgt ctccattact ttgaactttt gaagcagtta     1080

gaagaaaaaa gtgaagatca agaagacaag gaatgtttaa aacaagcaat aacagctttg     1140

cttaatgttc agagtggtat ggaaaaaata tgttctaaaa gtcttgcaaa acgaagactg     1200

agtgaatctg catgtcggtt ttatagtcag caaatgaagg ggaaacaact agcaatcaag     1260

aagatgaacg agattcagaa gaatattgat ggttgggagg gaaaagacat tggacagtgt     1320

tgtaatgaat ttataatgga aggaactctt acacgtgtag gagccaaaca tgagagacac     1380

atatttctct ttgatggctt aatgatttgc tgtaaatcaa atcatgggca gccaagactt     1440

cctggtgcta gcaatgcaga atatcgtctt aaagaaaagt tttttatgcg aaaggtacaa     1500

attaatgata aagatgacac caatgaatac aagcatgctt ttgaaataat tttaaaagat     1560

gaaaatagtg ttatattttc tgccaagtca gctgaagaga aaaacaattg gatggcagca     1620

ttgatatctt tacagtaccg gagtacactg gaaaggatgc ttgatgtaac aatgctacag     1680

gaagagaaag aggagcagat gaggctgcct agtgctgatg tttatagatt tgcagagcct     1740

gactctgaag agaatattat atttgaagag aacatgcagc ccaaggctgg aattccaatt     1800

atcaaagcag gaactgttat taaacttata gagaggctta cgtaccatat gtacgcagat     1860

cccaattttg ttcggacatt tcttacaaca tacagatcct tttgcaaacc tcaagaacta     1920

ctgagtctta taatagaaag gtttgaaatt ccagagcctg agccaacaga agctgatcgc     1980

atagctatag agaatggaga tcaacccttg agtgcagaac tgaaaagatt tagaaaagaa     2040

tatatacagc ctgtgcaact gcgagtatta aatgtatgtc ggcactgggt agagcaccac     2100

ttctatgatt ttgaaagaga tgcatatctt ttgcaacgaa tggaagaatt tattggaaca     2160

gtaagaggta aagcaatgaa aaaatgggtt gaatccatca ctaaaataat ccaaaggaaa     2220

aaaattgcaa gagacaatgg accaggtcat aatattacat ttcagagttc acctcccaca     2280

gttgagtggc atataagcag acctgggcac atagagactt ttgacctgct caccttacac     2340

ccaatagaaa ttgctcgaca actcacttta cttgaatcag atctataccg agctgtacag     2400

ccatcagaat tagttggaag tgtgtggaca aaagaagaca aagaaattaa ctctcctaat     2460

cttctgaaaa tgattcgaca taccaccaac ctcactctgt ggtttgagaa atgtattgta     2520

gaaactgaaa atttagaaga aagagtagct gtggtgagtc gaattattga gattctacaa     2580

gtctttcaag agttgaacaa ctttaatggt gtccttgagg ttgtcagtgc tatgaattca     2640

tcacctgttt acagactaga ccacacattt gagcaaatac caagtcgcca gaagaaaatt     2700

ttagaagaag ctcatgaatt gagtgaagat cactataaga aatatttggc aaaactcagg     2760

tctattaatc caccatgtgt gcctttcttt ggaatttatc tcactaatat cttgaaaaca     2820

gaagaaggca accctgaggt cctaaaaaga catggaaaag agcttataaa ctttagcaaa     2880

aggaggaaag tagcagaaat aacaggagag atccagcagt accaaaatca gccttactgt     2940

ttacgagtag aatcagatat caaaaggttc tttgaaaact tgaatccgat gggaaatagc     3000

atggagaagg aatttacaga ttatcttttc aacaaatccc tagaaataga accacgaaac     3060

cctaagcctc tcccaagatt tccaaaaaaa tatagctatc ccctaaaatc tcctggtgtt     3120

cgtccatcaa acccaagacc aggtaccatg aggcatccca cacctctgca gcaggagcca     3180

aggaaaatta gttatagtag gatccctgaa agtgaaacag aaagtacagc atctgcacca     3240

aattctccaa gaacaccgtt aacacctccg cctgcttctg gtgcttccag taccacagat     3300

gtttgcagtg tatttgattc cgatcattcg agcccttttc actcaagcaa tgataccgtc     3360

tttatccaag ttactctgcc ccatggccca agatctgctt ctgtatcatc tataagttta     3420

accaaaggca ctgatgaagt gcctgtccct cctcctgttc ctccacgaag acgaccagaa     3480

tctgccccag cagaatcttc accatctaag attatgtcta agcatttgga cagtccccca     3540

gccattcctc ctaggcaacc cacatcaaaa gcctattcac cacgatattc aatatcagac     3600

cggacctcta tctcagaccc tcctgaaagc cctcccttat taccaccacg agaacctgtg     3660

aggacacctg atgttttctc aagctcacca ctacatctcc aacctccccc tttgggcaaa     3720

aaaagtgacc atggcaatgc cttcttccca aacagccctt ccccctttac accacctcct     3780

cctcaaacac cttctcctca cggcacaaga aggcatctgc catcaccacc attgacacaa     3840

gaagtggacc ttcattccat tgctgggccg cctgttcctc cacgacaaag cacttctcaa     3900

catatcccta aactccctcc aaaaacttac aaaagggagc acacacaccc atccatgcac     3960

agagatggac caccactgtt ggagaatgcc cattcttcct ga                        4002


<210>  134
<211>  1333
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gln Ala Gln Gln Leu Pro Tyr Glu Phe Phe Ser Glu Glu Asn Ala 
1               5                   10                  15      


Pro Lys Trp Arg Gly Leu Leu Val Pro Ala Leu Lys Lys Val Gln Gly 
            20                  25                  30          


Gln Val His Pro Thr Leu Glu Ser Asn Asp Asp Ala Leu Gln Tyr Val 
        35                  40                  45              


Glu Glu Leu Ile Leu Gln Leu Leu Asn Met Leu Cys Gln Ala Gln Pro 
    50                  55                  60                  


Arg Ser Ala Ser Asp Val Glu Glu Arg Val Gln Lys Ser Phe Pro His 
65                  70                  75                  80  


Pro Ile Asp Lys Trp Ala Ile Ala Asp Ala Gln Ser Ala Ile Glu Lys 
                85                  90                  95      


Arg Lys Arg Arg Asn Pro Leu Ser Leu Pro Val Glu Lys Ile His Pro 
            100                 105                 110         


Leu Leu Lys Glu Val Leu Gly Tyr Lys Ile Asp His Gln Val Ser Val 
        115                 120                 125             


Tyr Ile Val Ala Val Leu Glu Tyr Ile Ser Ala Asp Ile Leu Lys Leu 
    130                 135                 140                 


Val Gly Asn Tyr Val Arg Asn Ile Arg His Tyr Glu Ile Thr Lys Gln 
145                 150                 155                 160 


Asp Ile Lys Val Ala Met Cys Ala Asp Lys Val Leu Met Asp Met Phe 
                165                 170                 175     


His Gln Asp Val Glu Asp Ile Asn Ile Leu Ser Leu Thr Asp Glu Glu 
            180                 185                 190         


Pro Ser Thr Ser Gly Glu Gln Thr Tyr Tyr Asp Leu Val Lys Ala Phe 
        195                 200                 205             


Met Ala Glu Ile Arg Gln Tyr Ile Arg Glu Leu Asn Leu Ile Ile Lys 
    210                 215                 220                 


Val Phe Arg Glu Pro Phe Val Ser Asn Ser Lys Leu Phe Ser Ala Asn 
225                 230                 235                 240 


Asp Val Glu Asn Ile Phe Ser Arg Ile Val Asp Ile His Glu Leu Ser 
                245                 250                 255     


Val Lys Leu Leu Gly His Ile Glu Asp Thr Val Glu Met Thr Asp Glu 
            260                 265                 270         


Gly Ser Pro His Pro Leu Val Gly Ser Cys Phe Glu Asp Leu Ala Glu 
        275                 280                 285             


Glu Leu Ala Phe Asp Pro Tyr Glu Ser Tyr Ala Arg Asp Ile Leu Arg 
    290                 295                 300                 


Pro Gly Phe His Asp Arg Phe Leu Ser Gln Leu Ser Lys Pro Gly Ala 
305                 310                 315                 320 


Ala Leu Tyr Leu Gln Ser Ile Gly Glu Gly Phe Lys Glu Ala Val Gln 
                325                 330                 335     


Tyr Val Leu Pro Arg Leu Leu Leu Ala Pro Val Tyr His Cys Leu His 
            340                 345                 350         


Tyr Phe Glu Leu Leu Lys Gln Leu Glu Glu Lys Ser Glu Asp Gln Glu 
        355                 360                 365             


Asp Lys Glu Cys Leu Lys Gln Ala Ile Thr Ala Leu Leu Asn Val Gln 
    370                 375                 380                 


Ser Gly Met Glu Lys Ile Cys Ser Lys Ser Leu Ala Lys Arg Arg Leu 
385                 390                 395                 400 


Ser Glu Ser Ala Cys Arg Phe Tyr Ser Gln Gln Met Lys Gly Lys Gln 
                405                 410                 415     


Leu Ala Ile Lys Lys Met Asn Glu Ile Gln Lys Asn Ile Asp Gly Trp 
            420                 425                 430         


Glu Gly Lys Asp Ile Gly Gln Cys Cys Asn Glu Phe Ile Met Glu Gly 
        435                 440                 445             


Thr Leu Thr Arg Val Gly Ala Lys His Glu Arg His Ile Phe Leu Phe 
    450                 455                 460                 


Asp Gly Leu Met Ile Cys Cys Lys Ser Asn His Gly Gln Pro Arg Leu 
465                 470                 475                 480 


Pro Gly Ala Ser Asn Ala Glu Tyr Arg Leu Lys Glu Lys Phe Phe Met 
                485                 490                 495     


Arg Lys Val Gln Ile Asn Asp Lys Asp Asp Thr Asn Glu Tyr Lys His 
            500                 505                 510         


Ala Phe Glu Ile Ile Leu Lys Asp Glu Asn Ser Val Ile Phe Ser Ala 
        515                 520                 525             


Lys Ser Ala Glu Glu Lys Asn Asn Trp Met Ala Ala Leu Ile Ser Leu 
    530                 535                 540                 


Gln Tyr Arg Ser Thr Leu Glu Arg Met Leu Asp Val Thr Met Leu Gln 
545                 550                 555                 560 


Glu Glu Lys Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg 
                565                 570                 575     


Phe Ala Glu Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met 
            580                 585                 590         


Gln Pro Lys Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys 
        595                 600                 605             


Leu Ile Glu Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val 
    610                 615                 620                 


Arg Thr Phe Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu 
625                 630                 635                 640 


Leu Ser Leu Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr 
                645                 650                 655     


Glu Ala Asp Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala 
            660                 665                 670         


Glu Leu Lys Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg 
        675                 680                 685             


Val Leu Asn Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe 
    690                 695                 700                 


Glu Arg Asp Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr 
705                 710                 715                 720 


Val Arg Gly Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile 
                725                 730                 735     


Ile Gln Arg Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile 
            740                 745                 750         


Thr Phe Gln Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro 
        755                 760                 765             


Gly His Ile Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile 
    770                 775                 780                 


Ala Arg Gln Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln 
785                 790                 795                 800 


Pro Ser Glu Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile 
                805                 810                 815     


Asn Ser Pro Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr 
            820                 825                 830         


Leu Trp Phe Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg 
        835                 840                 845             


Val Ala Val Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu 
    850                 855                 860                 


Leu Asn Asn Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser 
865                 870                 875                 880 


Ser Pro Val Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg 
                885                 890                 895     


Gln Lys Lys Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr 
            900                 905                 910         


Lys Lys Tyr Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro 
        915                 920                 925             


Phe Phe Gly Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn 
    930                 935                 940                 


Pro Glu Val Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys 
945                 950                 955                 960 


Arg Arg Lys Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn 
                965                 970                 975     


Gln Pro Tyr Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu 
            980                 985                 990         


Asn Leu Asn Pro Met Gly Asn Ser  Met Glu Lys Glu Phe  Thr Asp Tyr 
        995                 1000                 1005             


Leu Phe  Asn Lys Ser Leu Glu  Ile Glu Pro Arg Asn  Pro Lys Pro 
    1010                 1015                 1020             


Leu Pro  Arg Phe Pro Lys Lys  Tyr Ser Tyr Pro Leu  Lys Ser Pro 
    1025                 1030                 1035             


Gly Val  Arg Pro Ser Asn Pro  Arg Pro Gly Thr Met  Arg His Pro 
    1040                 1045                 1050             


Thr Pro  Leu Gln Gln Glu Pro  Arg Lys Ile Ser Tyr  Ser Arg Ile 
    1055                 1060                 1065             


Pro Glu  Ser Glu Thr Glu Ser  Thr Ala Ser Ala Pro  Asn Ser Pro 
    1070                 1075                 1080             


Arg Thr  Pro Leu Thr Pro Pro  Pro Ala Ser Gly Ala  Ser Ser Thr 
    1085                 1090                 1095             


Thr Asp  Val Cys Ser Val Phe  Asp Ser Asp His Ser  Ser Pro Phe 
    1100                 1105                 1110             


His Ser  Ser Asn Asp Thr Val  Phe Ile Gln Val Thr  Leu Pro His 
    1115                 1120                 1125             


Gly Pro  Arg Ser Ala Ser Val  Ser Ser Ile Ser Leu  Thr Lys Gly 
    1130                 1135                 1140             


Thr Asp  Glu Val Pro Val Pro  Pro Pro Val Pro Pro  Arg Arg Arg 
    1145                 1150                 1155             


Pro Glu  Ser Ala Pro Ala Glu  Ser Ser Pro Ser Lys  Ile Met Ser 
    1160                 1165                 1170             


Lys His  Leu Asp Ser Pro Pro  Ala Ile Pro Pro Arg  Gln Pro Thr 
    1175                 1180                 1185             


Ser Lys  Ala Tyr Ser Pro Arg  Tyr Ser Ile Ser Asp  Arg Thr Ser 
    1190                 1195                 1200             


Ile Ser  Asp Pro Pro Glu Ser  Pro Pro Leu Leu Pro  Pro Arg Glu 
    1205                 1210                 1215             


Pro Val  Arg Thr Pro Asp Val  Phe Ser Ser Ser Pro  Leu His Leu 
    1220                 1225                 1230             


Gln Pro  Pro Pro Leu Gly Lys  Lys Ser Asp His Gly  Asn Ala Phe 
    1235                 1240                 1245             


Phe Pro  Asn Ser Pro Ser Pro  Phe Thr Pro Pro Pro  Pro Gln Thr 
    1250                 1255                 1260             


Pro Ser  Pro His Gly Thr Arg  Arg His Leu Pro Ser  Pro Pro Leu 
    1265                 1270                 1275             


Thr Gln  Glu Val Asp Leu His  Ser Ile Ala Gly Pro  Pro Val Pro 
    1280                 1285                 1290             


Pro Arg  Gln Ser Thr Ser Gln  His Ile Pro Lys Leu  Pro Pro Lys 
    1295                 1300                 1305             


Thr Tyr  Lys Arg Glu His Thr  His Pro Ser Met His  Arg Asp Gly 
    1310                 1315                 1320             


Pro Pro  Leu Leu Glu Asn Ala  His Ser Ser 
    1325                 1330             


<210>  135
<211>  3186
<212>  DNA
<213>  Homo sapiens

<400>  135
atgccggggc cccggcgccc cgctggctcc cgcctgcgcc tgctcctgct cctgctgctg       60

ccgccgctgc tgctgctgct ccggggcagc cacgcgggca acctgacggt agccgtggta      120

ctgccgctgg ccaatacctc gtacccctgg tcgtgggcgc gcgtgggacc cgccgtggag      180

ctggccctgg cccaggtgaa ggcgcgcccc gacttgctgc cgggctggac ggtccgcacg      240

gtgctgggca gcagcgaaaa cgcgctgggc gtctgctccg acaccgcagc gcccctggcc      300

gcggtggacc tcaagtggga gcacaacccc gctgtgttcc tgggccccgg ctgcgtgtac      360

gccgccgccc cagtggggcg cttcaccgcg cactggcggg tcccgctgct gaccgccggc      420

gccccggcgc tgggcttcgg tgtcaaggac gagtatgcgc tgaccacccg cgcggggccc      480

agctacgcca agctggggga cttcgtggcg gcgctgcacc gacggctggg ctgggagcgc      540

caagcgctca tgctctacgc ctaccggccg ggtgacgaag agcactgctt cttcctcgtg      600

gaggggctgt tcatgcgggt ccgcgaccgc ctcaatatta cggtggacca cctggagttc      660

gccgaggacg acctcagcca ctacaccagg ctgctgcgga ccatgccgcg caaaggccga      720

gttatctaca tctgcagctc ccctgatgcc ttcagaaccc tcatgctcct ggccctggaa      780

gctggcttgt gtggggagga ctacgttttc ttccacctgg atatctttgg gcaaagcctg      840

caaggtggac agggccctgc tccccgcagg ccctgggaga gaggggatgg gcaggatgtc      900

agtgcccgcc aggcctttca ggctgccaaa atcattacat ataaagaccc agataatccc      960

gagtacttgg aattcctgaa gcagttaaaa cacctggcct atgagcagtt caacttcacc     1020

atggaggatg gcctggtgaa caccatccca gcatccttcc acgacgggct cctgctctat     1080

atccaggcag tgacggagac tctggcacat gggggaactg ttactgatgg ggagaacatc     1140

actcagcgga tgtggaaccg aagctttcaa ggtgtgacag gatacctgaa aattgatagc     1200

agtggcgatc gggaaacaga cttctccctc tgggatatgg atcccgagaa tggtgccttc     1260

agggttgtac tgaactacaa tgggacttcc caagagctgg tggctgtgtc ggggcgcaaa     1320

ctgaactggc ccctggggta ccctcctcct gacatcccca aatgtggctt tgacaacgaa     1380

gacccagcat gcaaccaaga tcacctttcc accctggagg tgctggcttt ggtgggcagc     1440

ctctccttgc tcggcattct gattgtctcc ttcttcatat acaggaagat gcagctggag     1500

aaggaactgg cctcggagct gtggcgggtg cgctgggagg acgttgagcc cagtagcctt     1560

gagaggcacc tgcggagtgc aggcagccgg ctgaccctga gcgggagagg ctccaattac     1620

ggctccctgc taaccacaga gggccagttc caagtctttg ccaagacagc atattataag     1680

ggcaacctcg tggctgtgaa acgtgtgaac cgtaaacgca ttgagctgac acgaaaagtc     1740

ctgtttgaac tgaagcatat gcgggatgtg cagaatgaac acctgaccag gtttgtggga     1800

gcctgcaccg acccccccaa tatctgcatc ctcacagagt actgtccccg tgggagcctg     1860

caggacattc tggagaatga gagcatcacc ctggactgga tgttccggta ctcactcacc     1920

aatgacatcg tcaagggcat gctgtttcta cacaatgggg ctatctgttc ccatgggaac     1980

ctcaagtcat ccaactgcgt ggtagatggg cgctttgtgc tcaagatcac cgactatggg     2040

ctggagagct tcagggacct ggacccagag caaggacaca ccgtttatgc caaaaagctg     2100

tggacggccc ctgagctcct gcgaatggct tcaccccctg tgcggggctc ccaggctggt     2160

gacgtataca gctttgggat catccttcag gagattgccc tgaggagtgg ggtcttccac     2220

gtggaaggtt tggacctgag ccccaaagag atcatcgagc gggtgactcg gggtgagcag     2280

ccccccttcc ggccctccct ggccctgcag agtcacctgg aggagttggg gctgctcatg     2340

cagcggtgct gggctgagga cccacaggag aggccaccat tccagcagat ccgcctgacg     2400

ttgcgcaaat ttaacaggga gaacagcagc aacatcctgg acaacctgct gtcccgcatg     2460

gagcagtacg cgaacaatct ggaggaactg gtggaggagc ggacccaggc atacctggag     2520

gagaagcgca aggctgaggc cctgctctac cagatcctgc ctcactcagt ggctgagcag     2580

ctgaagcgtg gggagacggt gcaggccgaa gcctttgaca gtgttaccat ctacttcagt     2640

gacattgtgg gtttcacagc gctgtcggcg gagagcacac ccatgcaggt ggtgaccctg     2700

ctcaatgacc tgtacacttg ctttgatgct gtcatagaca actttgatgt gtacaaggtg     2760

gagacaattg gcgatgccta catggtggtg tcagggctcc ctgtgcggaa cgggcggcta     2820

cacgcctgcg aggtagcccg catggccctg gcactgctgg atgctgtgcg ctccttccga     2880

atccgccacc ggccccagga gcagctgcgc ttgcgcattg gcatccacac aggacctgtg     2940

tgtgctggag tggtgggact gaagatgccc cgttactgtc tctttgggga tacagtcaac     3000

acagcctcaa gaatggagtc taatggggaa gccctgaaga tccacttgtc ttctgagacc     3060

aaggctgtcc tggaggagtt tggtggtttc gagctggagc ttcgagggga tgtagaaatg     3120

aagggcaaag gcaaggttcg gacctactgg ctccttgggg agagggggag tagcacccga     3180

ggctga                                                                3186


<210>  136
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Pro Gly Pro Arg Arg Pro Ala Gly Ser Arg Leu Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Leu Arg Gly Ser His Ala 
            20                  25                  30          


Gly Asn Leu Thr Val Ala Val Val Leu Pro Leu Ala Asn Thr Ser Tyr 
        35                  40                  45              


Pro Trp Ser Trp Ala Arg Val Gly Pro Ala Val Glu Leu Ala Leu Ala 
    50                  55                  60                  


Gln Val Lys Ala Arg Pro Asp Leu Leu Pro Gly Trp Thr Val Arg Thr 
65                  70                  75                  80  


Val Leu Gly Ser Ser Glu Asn Ala Leu Gly Val Cys Ser Asp Thr Ala 
                85                  90                  95      


Ala Pro Leu Ala Ala Val Asp Leu Lys Trp Glu His Asn Pro Ala Val 
            100                 105                 110         


Phe Leu Gly Pro Gly Cys Val Tyr Ala Ala Ala Pro Val Gly Arg Phe 
        115                 120                 125             


Thr Ala His Trp Arg Val Pro Leu Leu Thr Ala Gly Ala Pro Ala Leu 
    130                 135                 140                 


Gly Phe Gly Val Lys Asp Glu Tyr Ala Leu Thr Thr Arg Ala Gly Pro 
145                 150                 155                 160 


Ser Tyr Ala Lys Leu Gly Asp Phe Val Ala Ala Leu His Arg Arg Leu 
                165                 170                 175     


Gly Trp Glu Arg Gln Ala Leu Met Leu Tyr Ala Tyr Arg Pro Gly Asp 
            180                 185                 190         


Glu Glu His Cys Phe Phe Leu Val Glu Gly Leu Phe Met Arg Val Arg 
        195                 200                 205             


Asp Arg Leu Asn Ile Thr Val Asp His Leu Glu Phe Ala Glu Asp Asp 
    210                 215                 220                 


Leu Ser His Tyr Thr Arg Leu Leu Arg Thr Met Pro Arg Lys Gly Arg 
225                 230                 235                 240 


Val Ile Tyr Ile Cys Ser Ser Pro Asp Ala Phe Arg Thr Leu Met Leu 
                245                 250                 255     


Leu Ala Leu Glu Ala Gly Leu Cys Gly Glu Asp Tyr Val Phe Phe His 
            260                 265                 270         


Leu Asp Ile Phe Gly Gln Ser Leu Gln Gly Gly Gln Gly Pro Ala Pro 
        275                 280                 285             


Arg Arg Pro Trp Glu Arg Gly Asp Gly Gln Asp Val Ser Ala Arg Gln 
    290                 295                 300                 


Ala Phe Gln Ala Ala Lys Ile Ile Thr Tyr Lys Asp Pro Asp Asn Pro 
305                 310                 315                 320 


Glu Tyr Leu Glu Phe Leu Lys Gln Leu Lys His Leu Ala Tyr Glu Gln 
                325                 330                 335     


Phe Asn Phe Thr Met Glu Asp Gly Leu Val Asn Thr Ile Pro Ala Ser 
            340                 345                 350         


Phe His Asp Gly Leu Leu Leu Tyr Ile Gln Ala Val Thr Glu Thr Leu 
        355                 360                 365             


Ala His Gly Gly Thr Val Thr Asp Gly Glu Asn Ile Thr Gln Arg Met 
    370                 375                 380                 


Trp Asn Arg Ser Phe Gln Gly Val Thr Gly Tyr Leu Lys Ile Asp Ser 
385                 390                 395                 400 


Ser Gly Asp Arg Glu Thr Asp Phe Ser Leu Trp Asp Met Asp Pro Glu 
                405                 410                 415     


Asn Gly Ala Phe Arg Val Val Leu Asn Tyr Asn Gly Thr Ser Gln Glu 
            420                 425                 430         


Leu Val Ala Val Ser Gly Arg Lys Leu Asn Trp Pro Leu Gly Tyr Pro 
        435                 440                 445             


Pro Pro Asp Ile Pro Lys Cys Gly Phe Asp Asn Glu Asp Pro Ala Cys 
    450                 455                 460                 


Asn Gln Asp His Leu Ser Thr Leu Glu Val Leu Ala Leu Val Gly Ser 
465                 470                 475                 480 


Leu Ser Leu Leu Gly Ile Leu Ile Val Ser Phe Phe Ile Tyr Arg Lys 
                485                 490                 495     


Met Gln Leu Glu Lys Glu Leu Ala Ser Glu Leu Trp Arg Val Arg Trp 
            500                 505                 510         


Glu Asp Val Glu Pro Ser Ser Leu Glu Arg His Leu Arg Ser Ala Gly 
        515                 520                 525             


Ser Arg Leu Thr Leu Ser Gly Arg Gly Ser Asn Tyr Gly Ser Leu Leu 
    530                 535                 540                 


Thr Thr Glu Gly Gln Phe Gln Val Phe Ala Lys Thr Ala Tyr Tyr Lys 
545                 550                 555                 560 


Gly Asn Leu Val Ala Val Lys Arg Val Asn Arg Lys Arg Ile Glu Leu 
                565                 570                 575     


Thr Arg Lys Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Asn 
            580                 585                 590         


Glu His Leu Thr Arg Phe Val Gly Ala Cys Thr Asp Pro Pro Asn Ile 
        595                 600                 605             


Cys Ile Leu Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
    610                 615                 620                 


Glu Asn Glu Ser Ile Thr Leu Asp Trp Met Phe Arg Tyr Ser Leu Thr 
625                 630                 635                 640 


Asn Asp Ile Val Lys Gly Met Leu Phe Leu His Asn Gly Ala Ile Cys 
                645                 650                 655     


Ser His Gly Asn Leu Lys Ser Ser Asn Cys Val Val Asp Gly Arg Phe 
            660                 665                 670         


Val Leu Lys Ile Thr Asp Tyr Gly Leu Glu Ser Phe Arg Asp Leu Asp 
        675                 680                 685             


Pro Glu Gln Gly His Thr Val Tyr Ala Lys Lys Leu Trp Thr Ala Pro 
    690                 695                 700                 


Glu Leu Leu Arg Met Ala Ser Pro Pro Val Arg Gly Ser Gln Ala Gly 
705                 710                 715                 720 


Asp Val Tyr Ser Phe Gly Ile Ile Leu Gln Glu Ile Ala Leu Arg Ser 
                725                 730                 735     


Gly Val Phe His Val Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile Ile 
            740                 745                 750         


Glu Arg Val Thr Arg Gly Glu Gln Pro Pro Phe Arg Pro Ser Leu Ala 
        755                 760                 765             


Leu Gln Ser His Leu Glu Glu Leu Gly Leu Leu Met Gln Arg Cys Trp 
    770                 775                 780                 


Ala Glu Asp Pro Gln Glu Arg Pro Pro Phe Gln Gln Ile Arg Leu Thr 
785                 790                 795                 800 


Leu Arg Lys Phe Asn Arg Glu Asn Ser Ser Asn Ile Leu Asp Asn Leu 
                805                 810                 815     


Leu Ser Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Glu Leu Val Glu 
            820                 825                 830         


Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala Leu 
        835                 840                 845             


Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg Gly 
    850                 855                 860                 


Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe Ser 
865                 870                 875                 880 


Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met Gln 
                885                 890                 895     


Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Val Ile 
            900                 905                 910         


Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met 
        915                 920                 925             


Val Val Ser Gly Leu Pro Val Arg Asn Gly Arg Leu His Ala Cys Glu 
    930                 935                 940                 


Val Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Arg Ser Phe Arg 
945                 950                 955                 960 


Ile Arg His Arg Pro Gln Glu Gln Leu Arg Leu Arg Ile Gly Ile His 
                965                 970                 975     


Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg Tyr 
            980                 985                 990         


Cys Leu Phe Gly Asp Thr Val Asn  Thr Ala Ser Arg Met  Glu Ser Asn 
        995                 1000                 1005             


Gly Glu  Ala Leu Lys Ile His  Leu Ser Ser Glu Thr  Lys Ala Val 
    1010                 1015                 1020             


Leu Glu  Glu Phe Gly Gly Phe  Glu Leu Glu Leu Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Met  Lys Gly Lys Gly Lys  Val Arg Thr Tyr Trp  Leu Leu Gly 
    1040                 1045                 1050             


Glu Arg  Gly Ser Ser Thr Arg  Gly 
    1055                 1060     


<210>  137
<211>  3927
<212>  DNA
<213>  Homo sapiens

<400>  137
atgaagccgg cgacaggact ttgggtctgg gtgagccttc tcgtggcggc ggggaccgtc       60

cagcccagcg attctcagtc agtgtgtgca ggaacggaga ataaactgag ctctctctct      120

gacctggaac agcagtaccg agccttgcgc aagtactatg aaaactgtga ggttgtcatg      180

ggcaacctgg agataaccag cattgagcac aaccgggacc tctccttcct gcggtctgtt      240

cgagaagtca caggctacgt gttagtggct cttaatcagt ttcgttacct gcctctggag      300

aatttacgca ttattcgtgg gacaaaactt tatgaggatc gatatgcctt ggcaatattt      360

ttaaactaca gaaaagatgg aaactttgga cttcaagaac ttggattaaa gaacttgaca      420

gaaatcctaa atggtggagt ctatgtagac cagaacaaat tcctttgtta tgcagacacc      480

attcattggc aagatattgt tcggaaccca tggccttcca acttgactct tgtgtcaaca      540

aatggtagtt caggatgtgg acgttgccat aagtcctgta ctggccgttg ctggggaccc      600

acagaaaatc attgccagac tttgacaagg acggtgtgtg cagaacaatg tgacggcaga      660

tgctacggac cttacgtcag tgactgctgc catcgagaat gtgctggagg ctgctcagga      720

cctaaggaca cagactgctt tgcctgcatg aatttcaatg acagtggagc atgtgttact      780

cagtgtcccc aaacctttgt ctacaatcca accacctttc aactggagca caatttcaat      840

gcaaagtaca catatggagc attctgtgtc aagaaatgtc cacataactt tgtggtagat      900

tccagttctt gtgtgcgtgc ctgccctagt tccaagatgg aagtagaaga aaatgggatt      960

aaaatgtgta aaccttgcac tgacatttgc ccaaaagctt gtgatggcat tggcacagga     1020

tcattgatgt cagctcagac tgtggattcc agtaacattg acaaattcat aaactgtacc     1080

aagatcaatg ggaatttgat ctttctagtc actggtattc atggggaccc ttacaatgca     1140

attgaagcca tagacccaga gaaactgaac gtctttcgga cagtcagaga gataacaggt     1200

ttcctgaaca tacagtcatg gccaccaaac atgactgact tcagtgtttt ttctaacctg     1260

gtgaccattg gtggaagagt actctatagt ggcctgtcct tgcttatcct caagcaacag     1320

ggcatcacct ctctacagtt ccagtccctg aaggaaatca gcgcaggaaa catctatatt     1380

actgacaaca gcaacctgtg ttattatcat accattaact ggacaacact cttcagcaca     1440

atcaaccaga gaatagtaat ccgggacaac agaaaagctg aaaattgtac tgctgaagga     1500

atggtgtgca accatctgtg ttccagtgat ggctgttggg gacctgggcc agaccaatgt     1560

ctgtcgtgtc gccgcttcag tagaggaagg atctgcatag agtcttgtaa cctctatgat     1620

ggtgaatttc gggagtttga gaatggctcc atctgtgtgg agtgtgaccc ccagtgtgag     1680

aagatggaag atggcctcct cacatgccat ggaccgggtc ctgacaactg tacaaagtgc     1740

tctcatttta aagatggccc aaactgtgtg gaaaaatgtc cagatggctt acagggggca     1800

aacagtttca ttttcaagta tgctgatcca gatcgggagt gccacccatg ccatccaaac     1860

tgcacccaag ggtgtaacgg tcccactagt catgactgca tttactaccc atggacgggc     1920

cattccactt taccacaaca tgctagaact cccctgattg cagctggagt aattggtggg     1980

ctcttcattc tggtcattgt gggtctgaca tttgctgttt atgttagaag gaagagcatc     2040

aaaaagaaaa gagccttgag aagattcttg gaaacagagt tggtggaacc attaactccc     2100

agtggcacag cacccaatca agctcaactt cgtattttga aagaaactga gctgaagagg     2160

gtaaaagtcc ttggctcagg tgcttttgga acggtttata aaggtatttg ggtacctgaa     2220

ggagaaactg tgaagattcc tgtggctatt aagattctta atgagacaac tggtcccaag     2280

gcaaatgtgg agttcatgga tgaagctctg atcatggcaa gtatggatca tccacaccta     2340

gtccggttgc tgggtgtgtg tctgagccca accatccagc tggttactca acttatgccc     2400

catggctgcc tgttggagta tgtccacgag cacaaggata acattggatc acaactgctg     2460

cttaactggt gtgtccagat agctaaggga atgatgtacc tggaagaaag acgactcgtt     2520

catcgggatt tggcagcccg taatgtctta gtgaaatctc caaaccatgt gaaaatcaca     2580

gattttgggc tagccagact cttggaagga gatgaaaaag agtacaatgc tgatggagga     2640

aagatgccaa ttaaatggat ggctctggag tgtatacatt acaggaaatt cacccatcag     2700

agtgacgttt ggagctatgg agttactata tgggaactga tgacctttgg aggaaaaccc     2760

tatgatggaa ttccaacgcg agaaatccct gatttattag agaaaggaga acgtttgcct     2820

cagcctccca tctgcactat tgacgtttac atggtcatgg tcaaatgttg gatgattgat     2880

gctgacagta gacctaaatt taaggaactg gctgctgagt tttcaaggat ggctcgagac     2940

cctcaaagat acctagttat tcagggtgat gatcgtatga agcttcccag tccaaatgac     3000

agcaagttct ttcagaatct cttggatgaa gaggatttgg aagatatgat ggatgctgag     3060

gagtacttgg tccctcaggc tttcaacatc ccacctccca tctatacttc cagagcaaga     3120

attgactcga ataggagtga aattggacac agccctcctc ctgcctacac ccccatgtca     3180

ggaaaccagt ttgtataccg agatggaggt tttgctgctg aacaaggagt gtctgtgccc     3240

tacagagccc caactagcac aattccagaa gctcctgtgg cacagggtgc tactgctgag     3300

atttttgatg actcctgctg taatggcacc ctacgcaagc cagtggcacc ccatgtccaa     3360

gaggacagta gcacccagag gtacagtgct gaccccaccg tgtttgcccc agaacggagc     3420

ccacgaggag agctggatga ggaaggttac atgactccta tgcgagacaa acccaaacaa     3480

gaatacctga atccagtgga ggagaaccct tttgtttctc ggagaaaaaa tggagacctt     3540

caagcattgg ataatcccga atatcacaat gcatccaatg gtccacccaa ggccgaggat     3600

gagtatgtga atgagccact gtacctcaac acctttgcca acaccttggg aaaagctgag     3660

tacctgaaga acaacatact gtcaatgcca gagaaggcca agaaagcgtt tgacaaccct     3720

gactactgga accacagcct gccacctcgg agcacccttc agcacccaga ctacctgcag     3780

gagtacagca caaaatattt ttataaacag aatgggcgga tccggcctat tgtggcagag     3840

aatcctgaat acctctctga gttctccctg aagccaggca ctgtgctgcc gcctccacct     3900

tacagacacc ggaatactgt ggtgtaa                                         3927


<210>  138
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  139
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  139
atggacacca gaaataaggc ccagctcctt gtgctcctga ctcttctcag tgtgctcttc       60

tcacagactt cggcatggcc tctttacagg gcaccttctg ctctcaggtt gggtgacaga      120

ataccctttg agggagcaaa tgaacctgat caagtttcat taaaagaaga cattgacatg      180

ttgcaaaatg cattagctga aaatgacaca ccctattatg atgtatccag aaatgccagg      240

catgctgatg gagttttcac cagtgacttc agtaaactct tgggtcaact ttctgccaaa      300

aagtaccttg agtctcttat gggaaaacgt gttagtaaca tctcagaaga ccctgtacca      360

gtcaaacgtc actcagatgc agtcttcact gacaactata cccgccttag aaaacaaatg      420

gctgtaaaga aatatttgaa ctcaattctg aatggaaaga ggagcagtga gggagaatct      480

cccgactttc cagaagagtt agaaaaatga                                       510


<210>  140
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Asp Thr Arg Asn Lys Ala Gln Leu Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Val Leu Phe Ser Gln Thr Ser Ala Trp Pro Leu Tyr Arg Ala Pro 
            20                  25                  30          


Ser Ala Leu Arg Leu Gly Asp Arg Ile Pro Phe Glu Gly Ala Asn Glu 
        35                  40                  45              


Pro Asp Gln Val Ser Leu Lys Glu Asp Ile Asp Met Leu Gln Asn Ala 
    50                  55                  60                  


Leu Ala Glu Asn Asp Thr Pro Tyr Tyr Asp Val Ser Arg Asn Ala Arg 
65                  70                  75                  80  


His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
                85                  90                  95      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met Gly Lys Arg Val Ser 
            100                 105                 110         


Asn Ile Ser Glu Asp Pro Val Pro Val Lys Arg His Ser Asp Ala Val 
        115                 120                 125             


Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln Met Ala Val Lys Lys 
    130                 135                 140                 


Tyr Leu Asn Ser Ile Leu Asn Gly Lys Arg Ser Ser Glu Gly Glu Ser 
145                 150                 155                 160 


Pro Asp Phe Pro Glu Glu Leu Glu Lys 
                165                 


<210>  141
<211>  5808
<212>  DNA
<213>  Homo sapiens

<400>  141
atgggagatt cggagatggc agtctttggg gctgccgccc cctacctgcg caagtcagag       60

aaggagcggc tagaagcgca gaccaggcct tttgacctca agaaggatgt cttcgtgcct      120

gatgacaaac aggagtttgt caaggccaag atcgtgtctc gagagggtgg caaagtcact      180

gccgagactg agtatggcaa gacagtgacc gtgaaggagg accaggtgat gcagcagaac      240

ccacccaagt tcgacaaaat cgaggacatg gccatgctga ccttcctgca tgagcccgcg      300

gtgctctaca acctcaagga tcgctacggc tcctggatga tctacaccta ctcgggcctc      360

ttctgtgtca ccgtcaaccc ttacaagtgg ctgccggtgt acactcctga ggtggtggct      420

gcctaccggg gcaagaagag gagcgaggcc ccgccccaca tcttctccat ctccgacaac      480

gcctatcagt acatgctgac agacagagaa aaccagtcca tcctgatcac cggagaatcc      540

ggagcaggga agacagtcaa caccaagagg gtcatccagt actttgctgt tattgcagcc      600

attggggacc gcagcaagaa ggaccagagc ccgggcaagg gcaccctgga ggaccagatc      660

atccaggcca accctgctct ggaggccttt ggcaatgcca agaccgtccg gaacgacaac      720

tcctcccgct tcgggaaatt cattcgaatt cattttgggg caacaggaaa gttggcatct      780

gcagacatag agacctatct tctggaaaaa tccagagtta ttttccagct gaaagcagag      840

agagattatc acattttcta ccaaatcctg tctaacaaaa agcctgagct gctggacatg      900

ctgctgatca ccaacaaccc ctacgattat gcattcatct cccaaggaga gaccaccgtg      960

gcctccattg atgacgctga ggagctcatg gccactgata acgcttttga tgtgctgggc     1020

ttcacttcag aggagaaaaa ctccatgtat aagctgacag gcgccatcat gcactttgga     1080

aacatgaagt tcaagctgaa gcagcgggag gagcaggcgg agccagacgg cactgaagag     1140

gctgacaagt ctgcctacct catggggctg aactcagccg acctgctcaa ggggctgtgc     1200

caccctcggg tgaaagtggg caatgagtac gtcaccaagg ggcagaatgt ccagcaggtg     1260

atatatgcca ctggggcact ggccaaggca gtgtatgaga ggatgttcaa ctggatggtg     1320

acgcgcatca atgccaccct ggagaccaag cagccacgcc agtacttcat aggagtcctg     1380

gacatcgctg gcttcgagat cttcgatttc aacagctttg agcagctctg catcaacttc     1440

accaacgaga agctgcagca gttcttcaac caccacatgt ttgtgctgga gcaggaggag     1500

tacaagaagg agggcatcga gtggacattc attgactttg gcatggacct gcaggcctgc     1560

attgacctca tcgagaagcc catgggcatc atgtccatcc tggaagagga gtgcatgttc     1620

cccaaggcca ccgacatgac cttcaaggcc aagctgtttg acaaccacct gggcaaatcc     1680

gccaacttcc agaagccacg aaatatcaag gggaagcctg aagcccactt ctccctgatc     1740

cactatgccg gcatcgtgga ctacaacatc attggctggc tgcagaagaa caaggatcct     1800

ctcaatgaga ctgtcgtggg cttgtatcag aagtcttccc tcaagttgct cagcaccctg     1860

tttgccaact atgctggggc tgatgcgcct attgagaagg gcaaaggcaa ggccaagaaa     1920

ggctcgtcct ttcagactgt gtcagctctg cacagggaaa atctgaacaa gctgatgacc     1980

aacttgcgct ccacccatcc ccactttgta cgttgtatca tccctaatga gacaaagtct     2040

ccaggcgtga tggacaaccc cctggtcatg caccagctgc gctgcaatgg tgtgctggag     2100

ggcatccgca tctgcaggaa aggcttcccc aaccgcatcc tctacgggga cttccggcag     2160

aggtatcgca tcctgaaccc agcggccatc cctgagggac agttcattga tagcaggaag     2220

ggggcagaga agctgctcag ctccctggac attgatcaca accagtacaa gtttggccac     2280

accaaggtgt tcttcaaggc cgggctgctg gggctgctgg aggaaatgag ggacgagagg     2340

ctgagccgca tcatcacgcg tatccaggcc cagtcccgag gtgtgctcgc cagaatggag     2400

tacaaaaagc tgctggaacg tagagactcc ctgctggtaa tccagtggaa cattcgggcc     2460

ttcatggggg tcaagaattg gccctggatg aagctctact tcaagatcaa gccgctgctg     2520

aagagtgcag aaagagagaa ggagatggcc tccatgaagg aggagttcac acgcctcaaa     2580

gaggcgctag agaagtccga ggctcgccgc aaggagctgg aggagaagat ggtgtccctg     2640

ctgcaggaga agaatgacct gcagctccaa gtgcaggcgg aacaagacaa cctggcagat     2700

gctgaggagc gctgtgatca gctgatcaaa aacaagattc agctggaggc taaggtgaag     2760

gagatgaacg agaggctgga ggatgaggag gagatgaatg ctgagctcac tgccaagaag     2820

cgcaagttgg aagatgagtg ctcagagctc aaaagggaca tcgatgatct ggagctgaca     2880

ctggccaaag tggagaagga gaaacacgca acagagaaca aggtgaaaaa cctgacagag     2940

gagatggctg ggctggatga gatcattgcc aagctgacca aggagaagaa agctctgcaa     3000

gaggcccacc aacaggctct ggatgacctt caggccgagg aggacaaggt caacaccctg     3060

actaaggcca aagtcaagct ggagcagcaa gtggatgatc tggaaggatc cctggagcaa     3120

gagaagaagg tgcgcatgga cctggagcga gcgaagcgga agctggaggg cgacctgaag     3180

ctgacccagg agagcatcat ggacctggag aatgacaagc agcagctgga tgagcggctg     3240

aaaaaaaaag actttgagct gaatgctctc aacgcaagga ttgaggatga acaggccctc     3300

ggcagccagc tgcagaagaa gctcaaggag cttcaggcac gcatcgagga gctggaggag     3360

gagctggagt ccgagcgcac cgccagggct aaggtggaga agctgcgctc agacctgtct     3420

cgggagctgg aggagatcag cgagcggctg gaagaggccg gcggggccac gtccgtgcag     3480

atcgagatga acaagaagcg cgaggccgag ttccagaaga tgcggcggga cctggaggag     3540

gccacgctgc agcacgaggc cactgccgcg gccctgcgca agaagcacgc cgacagcgtg     3600

gccgagctgg gcgagcagat cgacaacctg cagcgggtga agcagaagct ggagaaggag     3660

aagagcgagt tcaagctgga gctggatgac gtcacctcca acatggagca gatcatcaag     3720

gccaaggcta acctggagaa gatgtgccgg accttggaag accagatgaa tgagcaccgg     3780

agcaaggcgg aggagaccca gcgttctgtc aacgacctca ccagccagcg ggccaagttg     3840

caaaccgaga atggtgagct gtcccggcag ctggatgaga aggaggcact gatctcccag     3900

ctgacccgag gcaagctcac ctacacccag cagctggagg acctcaagag gcagctggag     3960

gaggaggtta aggcgaagaa cgccctggcc cacgcactgc agtcggcccg gcatgactgc     4020

gacctgctgc gggagcagta cgaggaggag acggaggcca aggccgagct gcagcgcgtc     4080

ctttccaagg ccaactcgga ggtggcccag tggaggacca agtatgagac ggacgccatt     4140

cagcggactg aggagctcga ggaggccaag aagaagctgg cccagcggct gcaggaagct     4200

gaggaggccg tggaggctgt taatgccaag tgctcctcgc tggagaagac caagcaccgg     4260

ctacagaatg agatcgagga cttgatggtg gacgtagagc gctccaatgc tgctgctgca     4320

gccctggaca agaagcagag gaacttcgac aagatcctgg ccgagtggaa gcagaagtat     4380

gaggagtcgc agtcggagct ggagtcctcg cagaaggagg ctcgctccct cagcacagag     4440

ctcttcaaac tcaagaacgc ctatgaggag tccctggaac atctggagac cttcaagcgg     4500

gagaacaaaa acctgcagga ggagatctcc gacttgactg agcagttggg ttccagcgga     4560

aagactatcc atgagctgga gaaggtccga aagcagctgg aggccgagaa gatggagctg     4620

cagtcagccc tggaggaggc cgaggcctcc ctggagcacg aggagggcaa gatcctccgg     4680

gcccagctgg agttcaacca gatcaaggca gagatcgagc ggaagctggc agagaaggac     4740

gaggagatgg aacaggccaa gcgcaaccac ctgcgggtgg tggactcgct gcagacctcc     4800

ctggacgcag agacacgcag ccgcaacgag gccctgaggg tgaagaagaa gatggaagga     4860

gacctcaatg agatggagat ccagctcagc cacgccaacc gcatggccgc cgaggcccag     4920

aagcaagtca agagcctcca gagcttgttg aaggacaccc agattcagct ggacgatgca     4980

gtccgtgcca acgacgacct gaaggagaac atcgccatcg tggagcggcg caacaacctg     5040

ctgcaggctg agctggagga gttgcgtgcc gtggtggagc agacagagcg gtcccggaag     5100

ctggcggagc aggagctgat tgagactagt gagcgggtgc agctgctgca ttcccagaac     5160

accagcctca tcaaccagaa gaagaagatg gatgctgacc tgtcccagct ccagactgaa     5220

gtggaggagg cagtgcagga gtgcaggaat gctgaggaga aggccaagaa ggccatcacg     5280

gatgccgcca tgatggcaga ggagctgaag aaggagcagg acaccagcgc ccacctggag     5340

cgcatgaaga agaacatgga acagaccatt aaggacctgc agcaccggct ggacgaagcc     5400

gagcagatcg ccctcaaggg cggcaagaag cagctgcaga agctggaagc gcgggtgcgg     5460

gagctggaga atgagctgga ggccgagcag aagcgcaacg cagagtcggt gaagggcatg     5520

aggaagagcg agcggcgcat caaggagctc acctaccaga cggaggagga caggaaaaac     5580

ctgctgcggc tgcaggacct ggtagacaag ctgcagctaa aggtcaaggc ctacaagcgc     5640

caggccgagg aggcggagga gcaagccaac accaacctgt ccaagttccg caaggtgcag     5700

cacgagctgg atgaggcaga ggagcgggcg gacatcgccg agtcccaggt caacaagctg     5760

cgggccaaga gccgtgacat tggcacgaag ggcttgaatg aggagtag                  5808


<210>  142
<211>  1935
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gly Asp Ser Glu Met Ala Val Phe Gly Ala Ala Ala Pro Tyr Leu 
1               5                   10                  15      


Arg Lys Ser Glu Lys Glu Arg Leu Glu Ala Gln Thr Arg Pro Phe Asp 
            20                  25                  30          


Leu Lys Lys Asp Val Phe Val Pro Asp Asp Lys Gln Glu Phe Val Lys 
        35                  40                  45              


Ala Lys Ile Val Ser Arg Glu Gly Gly Lys Val Thr Ala Glu Thr Glu 
    50                  55                  60                  


Tyr Gly Lys Thr Val Thr Val Lys Glu Asp Gln Val Met Gln Gln Asn 
65                  70                  75                  80  


Pro Pro Lys Phe Asp Lys Ile Glu Asp Met Ala Met Leu Thr Phe Leu 
                85                  90                  95      


His Glu Pro Ala Val Leu Tyr Asn Leu Lys Asp Arg Tyr Gly Ser Trp 
            100                 105                 110         


Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Val Asn Pro Tyr 
        115                 120                 125             


Lys Trp Leu Pro Val Tyr Thr Pro Glu Val Val Ala Ala Tyr Arg Gly 
    130                 135                 140                 


Lys Lys Arg Ser Glu Ala Pro Pro His Ile Phe Ser Ile Ser Asp Asn 
145                 150                 155                 160 


Ala Tyr Gln Tyr Met Leu Thr Asp Arg Glu Asn Gln Ser Ile Leu Ile 
                165                 170                 175     


Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Thr Lys Arg Val Ile 
            180                 185                 190         


Gln Tyr Phe Ala Val Ile Ala Ala Ile Gly Asp Arg Ser Lys Lys Asp 
        195                 200                 205             


Gln Ser Pro Gly Lys Gly Thr Leu Glu Asp Gln Ile Ile Gln Ala Asn 
    210                 215                 220                 


Pro Ala Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn Asp Asn 
225                 230                 235                 240 


Ser Ser Arg Phe Gly Lys Phe Ile Arg Ile His Phe Gly Ala Thr Gly 
                245                 250                 255     


Lys Leu Ala Ser Ala Asp Ile Glu Thr Tyr Leu Leu Glu Lys Ser Arg 
            260                 265                 270         


Val Ile Phe Gln Leu Lys Ala Glu Arg Asp Tyr His Ile Phe Tyr Gln 
        275                 280                 285             


Ile Leu Ser Asn Lys Lys Pro Glu Leu Leu Asp Met Leu Leu Ile Thr 
    290                 295                 300                 


Asn Asn Pro Tyr Asp Tyr Ala Phe Ile Ser Gln Gly Glu Thr Thr Val 
305                 310                 315                 320 


Ala Ser Ile Asp Asp Ala Glu Glu Leu Met Ala Thr Asp Asn Ala Phe 
                325                 330                 335     


Asp Val Leu Gly Phe Thr Ser Glu Glu Lys Asn Ser Met Tyr Lys Leu 
            340                 345                 350         


Thr Gly Ala Ile Met His Phe Gly Asn Met Lys Phe Lys Leu Lys Gln 
        355                 360                 365             


Arg Glu Glu Gln Ala Glu Pro Asp Gly Thr Glu Glu Ala Asp Lys Ser 
    370                 375                 380                 


Ala Tyr Leu Met Gly Leu Asn Ser Ala Asp Leu Leu Lys Gly Leu Cys 
385                 390                 395                 400 


His Pro Arg Val Lys Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Asn 
                405                 410                 415     


Val Gln Gln Val Ile Tyr Ala Thr Gly Ala Leu Ala Lys Ala Val Tyr 
            420                 425                 430         


Glu Arg Met Phe Asn Trp Met Val Thr Arg Ile Asn Ala Thr Leu Glu 
        435                 440                 445             


Thr Lys Gln Pro Arg Gln Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly 
    450                 455                 460                 


Phe Glu Ile Phe Asp Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe 
465                 470                 475                 480 


Thr Asn Glu Lys Leu Gln Gln Phe Phe Asn His His Met Phe Val Leu 
                485                 490                 495     


Glu Gln Glu Glu Tyr Lys Lys Glu Gly Ile Glu Trp Thr Phe Ile Asp 
            500                 505                 510         


Phe Gly Met Asp Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met 
        515                 520                 525             


Gly Ile Met Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr 
    530                 535                 540                 


Asp Met Thr Phe Lys Ala Lys Leu Phe Asp Asn His Leu Gly Lys Ser 
545                 550                 555                 560 


Ala Asn Phe Gln Lys Pro Arg Asn Ile Lys Gly Lys Pro Glu Ala His 
                565                 570                 575     


Phe Ser Leu Ile His Tyr Ala Gly Ile Val Asp Tyr Asn Ile Ile Gly 
            580                 585                 590         


Trp Leu Gln Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Gly Leu 
        595                 600                 605             


Tyr Gln Lys Ser Ser Leu Lys Leu Leu Ser Thr Leu Phe Ala Asn Tyr 
    610                 615                 620                 


Ala Gly Ala Asp Ala Pro Ile Glu Lys Gly Lys Gly Lys Ala Lys Lys 
625                 630                 635                 640 


Gly Ser Ser Phe Gln Thr Val Ser Ala Leu His Arg Glu Asn Leu Asn 
                645                 650                 655     


Lys Leu Met Thr Asn Leu Arg Ser Thr His Pro His Phe Val Arg Cys 
            660                 665                 670         


Ile Ile Pro Asn Glu Thr Lys Ser Pro Gly Val Met Asp Asn Pro Leu 
        675                 680                 685             


Val Met His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg Ile 
    690                 695                 700                 


Cys Arg Lys Gly Phe Pro Asn Arg Ile Leu Tyr Gly Asp Phe Arg Gln 
705                 710                 715                 720 


Arg Tyr Arg Ile Leu Asn Pro Ala Ala Ile Pro Glu Gly Gln Phe Ile 
                725                 730                 735     


Asp Ser Arg Lys Gly Ala Glu Lys Leu Leu Ser Ser Leu Asp Ile Asp 
            740                 745                 750         


His Asn Gln Tyr Lys Phe Gly His Thr Lys Val Phe Phe Lys Ala Gly 
        755                 760                 765             


Leu Leu Gly Leu Leu Glu Glu Met Arg Asp Glu Arg Leu Ser Arg Ile 
    770                 775                 780                 


Ile Thr Arg Ile Gln Ala Gln Ser Arg Gly Val Leu Ala Arg Met Glu 
785                 790                 795                 800 


Tyr Lys Lys Leu Leu Glu Arg Arg Asp Ser Leu Leu Val Ile Gln Trp 
                805                 810                 815     


Asn Ile Arg Ala Phe Met Gly Val Lys Asn Trp Pro Trp Met Lys Leu 
            820                 825                 830         


Tyr Phe Lys Ile Lys Pro Leu Leu Lys Ser Ala Glu Arg Glu Lys Glu 
        835                 840                 845             


Met Ala Ser Met Lys Glu Glu Phe Thr Arg Leu Lys Glu Ala Leu Glu 
    850                 855                 860                 


Lys Ser Glu Ala Arg Arg Lys Glu Leu Glu Glu Lys Met Val Ser Leu 
865                 870                 875                 880 


Leu Gln Glu Lys Asn Asp Leu Gln Leu Gln Val Gln Ala Glu Gln Asp 
                885                 890                 895     


Asn Leu Ala Asp Ala Glu Glu Arg Cys Asp Gln Leu Ile Lys Asn Lys 
            900                 905                 910         


Ile Gln Leu Glu Ala Lys Val Lys Glu Met Asn Glu Arg Leu Glu Asp 
        915                 920                 925             


Glu Glu Glu Met Asn Ala Glu Leu Thr Ala Lys Lys Arg Lys Leu Glu 
    930                 935                 940                 


Asp Glu Cys Ser Glu Leu Lys Arg Asp Ile Asp Asp Leu Glu Leu Thr 
945                 950                 955                 960 


Leu Ala Lys Val Glu Lys Glu Lys His Ala Thr Glu Asn Lys Val Lys 
                965                 970                 975     


Asn Leu Thr Glu Glu Met Ala Gly Leu Asp Glu Ile Ile Ala Lys Leu 
            980                 985                 990         


Thr Lys Glu Lys Lys Ala Leu Gln  Glu Ala His Gln Gln  Ala Leu Asp 
        995                 1000                 1005             


Asp Leu  Gln Ala Glu Glu Asp  Lys Val Asn Thr Leu  Thr Lys Ala 
    1010                 1015                 1020             


Lys Val  Lys Leu Glu Gln Gln  Val Asp Asp Leu Glu  Gly Ser Leu 
    1025                 1030                 1035             


Glu Gln  Glu Lys Lys Val Arg  Met Asp Leu Glu Arg  Ala Lys Arg 
    1040                 1045                 1050             


Lys Leu  Glu Gly Asp Leu Lys  Leu Thr Gln Glu Ser  Ile Met Asp 
    1055                 1060                 1065             


Leu Glu  Asn Asp Lys Gln Gln  Leu Asp Glu Arg Leu  Lys Lys Lys 
    1070                 1075                 1080             


Asp Phe  Glu Leu Asn Ala Leu  Asn Ala Arg Ile Glu  Asp Glu Gln 
    1085                 1090                 1095             


Ala Leu  Gly Ser Gln Leu Gln  Lys Lys Leu Lys Glu  Leu Gln Ala 
    1100                 1105                 1110             


Arg Ile  Glu Glu Leu Glu Glu  Glu Leu Glu Ser Glu  Arg Thr Ala 
    1115                 1120                 1125             


Arg Ala  Lys Val Glu Lys Leu  Arg Ser Asp Leu Ser  Arg Glu Leu 
    1130                 1135                 1140             


Glu Glu  Ile Ser Glu Arg Leu  Glu Glu Ala Gly Gly  Ala Thr Ser 
    1145                 1150                 1155             


Val Gln  Ile Glu Met Asn Lys  Lys Arg Glu Ala Glu  Phe Gln Lys 
    1160                 1165                 1170             


Met Arg  Arg Asp Leu Glu Glu  Ala Thr Leu Gln His  Glu Ala Thr 
    1175                 1180                 1185             


Ala Ala  Ala Leu Arg Lys Lys  His Ala Asp Ser Val  Ala Glu Leu 
    1190                 1195                 1200             


Gly Glu  Gln Ile Asp Asn Leu  Gln Arg Val Lys Gln  Lys Leu Glu 
    1205                 1210                 1215             


Lys Glu  Lys Ser Glu Phe Lys  Leu Glu Leu Asp Asp  Val Thr Ser 
    1220                 1225                 1230             


Asn Met  Glu Gln Ile Ile Lys  Ala Lys Ala Asn Leu  Glu Lys Met 
    1235                 1240                 1245             


Cys Arg  Thr Leu Glu Asp Gln  Met Asn Glu His Arg  Ser Lys Ala 
    1250                 1255                 1260             


Glu Glu  Thr Gln Arg Ser Val  Asn Asp Leu Thr Ser  Gln Arg Ala 
    1265                 1270                 1275             


Lys Leu  Gln Thr Glu Asn Gly  Glu Leu Ser Arg Gln  Leu Asp Glu 
    1280                 1285                 1290             


Lys Glu  Ala Leu Ile Ser Gln  Leu Thr Arg Gly Lys  Leu Thr Tyr 
    1295                 1300                 1305             


Thr Gln  Gln Leu Glu Asp Leu  Lys Arg Gln Leu Glu  Glu Glu Val 
    1310                 1315                 1320             


Lys Ala  Lys Asn Ala Leu Ala  His Ala Leu Gln Ser  Ala Arg His 
    1325                 1330                 1335             


Asp Cys  Asp Leu Leu Arg Glu  Gln Tyr Glu Glu Glu  Thr Glu Ala 
    1340                 1345                 1350             


Lys Ala  Glu Leu Gln Arg Val  Leu Ser Lys Ala Asn  Ser Glu Val 
    1355                 1360                 1365             


Ala Gln  Trp Arg Thr Lys Tyr  Glu Thr Asp Ala Ile  Gln Arg Thr 
    1370                 1375                 1380             


Glu Glu  Leu Glu Glu Ala Lys  Lys Lys Leu Ala Gln  Arg Leu Gln 
    1385                 1390                 1395             


Glu Ala  Glu Glu Ala Val Glu  Ala Val Asn Ala Lys  Cys Ser Ser 
    1400                 1405                 1410             


Leu Glu  Lys Thr Lys His Arg  Leu Gln Asn Glu Ile  Glu Asp Leu 
    1415                 1420                 1425             


Met Val  Asp Val Glu Arg Ser  Asn Ala Ala Ala Ala  Ala Leu Asp 
    1430                 1435                 1440             


Lys Lys  Gln Arg Asn Phe Asp  Lys Ile Leu Ala Glu  Trp Lys Gln 
    1445                 1450                 1455             


Lys Tyr  Glu Glu Ser Gln Ser  Glu Leu Glu Ser Ser  Gln Lys Glu 
    1460                 1465                 1470             


Ala Arg  Ser Leu Ser Thr Glu  Leu Phe Lys Leu Lys  Asn Ala Tyr 
    1475                 1480                 1485             


Glu Glu  Ser Leu Glu His Leu  Glu Thr Phe Lys Arg  Glu Asn Lys 
    1490                 1495                 1500             


Asn Leu  Gln Glu Glu Ile Ser  Asp Leu Thr Glu Gln  Leu Gly Ser 
    1505                 1510                 1515             


Ser Gly  Lys Thr Ile His Glu  Leu Glu Lys Val Arg  Lys Gln Leu 
    1520                 1525                 1530             


Glu Ala  Glu Lys Met Glu Leu  Gln Ser Ala Leu Glu  Glu Ala Glu 
    1535                 1540                 1545             


Ala Ser  Leu Glu His Glu Glu  Gly Lys Ile Leu Arg  Ala Gln Leu 
    1550                 1555                 1560             


Glu Phe  Asn Gln Ile Lys Ala  Glu Ile Glu Arg Lys  Leu Ala Glu 
    1565                 1570                 1575             


Lys Asp  Glu Glu Met Glu Gln  Ala Lys Arg Asn His  Leu Arg Val 
    1580                 1585                 1590             


Val Asp  Ser Leu Gln Thr Ser  Leu Asp Ala Glu Thr  Arg Ser Arg 
    1595                 1600                 1605             


Asn Glu  Ala Leu Arg Val Lys  Lys Lys Met Glu Gly  Asp Leu Asn 
    1610                 1615                 1620             


Glu Met  Glu Ile Gln Leu Ser  His Ala Asn Arg Met  Ala Ala Glu 
    1625                 1630                 1635             


Ala Gln  Lys Gln Val Lys Ser  Leu Gln Ser Leu Leu  Lys Asp Thr 
    1640                 1645                 1650             


Gln Ile  Gln Leu Asp Asp Ala  Val Arg Ala Asn Asp  Asp Leu Lys 
    1655                 1660                 1665             


Glu Asn  Ile Ala Ile Val Glu  Arg Arg Asn Asn Leu  Leu Gln Ala 
    1670                 1675                 1680             


Glu Leu  Glu Glu Leu Arg Ala  Val Val Glu Gln Thr  Glu Arg Ser 
    1685                 1690                 1695             


Arg Lys  Leu Ala Glu Gln Glu  Leu Ile Glu Thr Ser  Glu Arg Val 
    1700                 1705                 1710             


Gln Leu  Leu His Ser Gln Asn  Thr Ser Leu Ile Asn  Gln Lys Lys 
    1715                 1720                 1725             


Lys Met  Asp Ala Asp Leu Ser  Gln Leu Gln Thr Glu  Val Glu Glu 
    1730                 1735                 1740             


Ala Val  Gln Glu Cys Arg Asn  Ala Glu Glu Lys Ala  Lys Lys Ala 
    1745                 1750                 1755             


Ile Thr  Asp Ala Ala Met Met  Ala Glu Glu Leu Lys  Lys Glu Gln 
    1760                 1765                 1770             


Asp Thr  Ser Ala His Leu Glu  Arg Met Lys Lys Asn  Met Glu Gln 
    1775                 1780                 1785             


Thr Ile  Lys Asp Leu Gln His  Arg Leu Asp Glu Ala  Glu Gln Ile 
    1790                 1795                 1800             


Ala Leu  Lys Gly Gly Lys Lys  Gln Leu Gln Lys Leu  Glu Ala Arg 
    1805                 1810                 1815             


Val Arg  Glu Leu Glu Asn Glu  Leu Glu Ala Glu Gln  Lys Arg Asn 
    1820                 1825                 1830             


Ala Glu  Ser Val Lys Gly Met  Arg Lys Ser Glu Arg  Arg Ile Lys 
    1835                 1840                 1845             


Glu Leu  Thr Tyr Gln Thr Glu  Glu Asp Arg Lys Asn  Leu Leu Arg 
    1850                 1855                 1860             


Leu Gln  Asp Leu Val Asp Lys  Leu Gln Leu Lys Val  Lys Ala Tyr 
    1865                 1870                 1875             


Lys Arg  Gln Ala Glu Glu Ala  Glu Glu Gln Ala Asn  Thr Asn Leu 
    1880                 1885                 1890             


Ser Lys  Phe Arg Lys Val Gln  His Glu Leu Asp Glu  Ala Glu Glu 
    1895                 1900                 1905             


Arg Ala  Asp Ile Ala Glu Ser  Gln Val Asn Lys Leu  Arg Ala Lys 
    1910                 1915                 1920             


Ser Arg  Asp Ile Gly Thr Lys  Gly Leu Asn Glu Glu  
    1925                 1930                 1935 


<210>  143
<211>  736
<212>  PRT
<213>  Dependoparvovirus Adeno-associated virus serotype 9

<400>  143

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  144
<211>  724
<212>  PRT
<213>  Dependoparvovirus Adeno-associated virus serotype 5

<400>  144

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  145
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  145

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Ser Gln Val Asn Gly Arg Pro Arg Asp Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  146
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  146

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  147
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  147

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Asn Val Ser Tyr Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  148
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  148

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Met Val Asn Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  149
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  149

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  150
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  150

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Asn Val Gly Thr Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  151
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  151

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Asn Val Ser Tyr Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  152
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  152

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Leu Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  153
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  153

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Gln Asp Ala Ser Leu Leu Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  154
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  154

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Gly Met Ser Phe Thr Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  155
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  155

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  156
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  156

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Gln Asp Ala Ser Leu Leu Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  157
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  157

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Gly Met Ser Phe Thr Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  158
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  158

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Leu Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  159
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  159

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 
    690                 695                 700                 


Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Pro Leu 
                725     


<210>  160
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  160

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val 
    690                 695                 700                 


Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Asn Leu 
                725 


<210>  161
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  161

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val 
305                 310                 315                 320 


Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys 
            340                 345                 350         


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
    370                 375                 380                 


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
385                 390                 395                 400 


Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala 
                405                 410                 415     


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
            420                 425                 430         


Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln 
        435                 440                 445             


Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly 
    450                 455                 460                 


Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr 
465                 470                 475                 480 


Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser 
                485                 490                 495     


Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala 
            500                 505                 510         


Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly 
        515                 520                 525             


Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala 
    530                 535                 540                 


Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro 
545                 550                 555                 560 


Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala 
                565                 570                 575     


Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro 
            580                 585                 590         


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met 
    610                 615                 620                 


Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu 
                645                 650                 655     


Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
            660                 665                 670         


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val 
    690                 695                 700                 


Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Asn Leu 
                725 


<210>  162
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  162

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  163
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  163

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn 
    690                 695                 700                 


Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu 
705                 710                 715                 720 


Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  164
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  164

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Phe 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  165
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  165

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Gln Trp 
    210                 215                 220                 


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  166
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  166

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Gln Trp 
    210                 215                 220                 


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala 
    690                 695                 700                 


Pro Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Pro Leu 
                725     


<210>  167
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  167

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val 
            660                 665                 670         


Glu Met Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  168
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  168

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  169
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  169

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  170
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  170

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asp Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Lys Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu Trp Glu Leu Lys 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn 
    690                 695                 700                 


Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu 
705                 710                 715                 720 


Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  171
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  171

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr 
    690                 695                 700                 


Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr 
705                 710                 715                 720 


Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735 


<210>  172
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  172

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  173
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  173

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  174
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  174

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
    210                 215                 220                 


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  175
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  175

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp 
    210                 215                 220                 


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
225                 230                 235                 240 


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly 
                245                 250                 255     


Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn 
    290                 295                 300                 


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly 
305                 310                 315                 320 


Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly 
            340                 345                 350         


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
    370                 375                 380                 


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
385                 390                 395                 400 


Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
                405                 410                 415     


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            420                 425                 430         


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        435                 440                 445             


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    450                 455                 460                 


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
465                 470                 475                 480 


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                485                 490                 495     


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            500                 505                 510         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        515                 520                 525             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    530                 535                 540                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
545                 550                 555                 560 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                565                 570                 575     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            580                 585                 590         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    610                 615                 620                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys 
                645                 650                 655     


Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
            660                 665                 670         


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
        675                 680                 685             


Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala 
    690                 695                 700                 


Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
705                 710                 715                 720 


Tyr Leu Thr Arg Asn Leu 
                725     


<210>  176
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  176

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  177
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  177

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  178
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  178

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  179
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  179

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  180
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  180

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  181
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  181

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  182
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  182

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Asn Asn Tyr 
    690                 695                 700                 


Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp Ser Thr Gly Glu Tyr 
705                 710                 715                 720 


Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735 


<210>  183
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  183

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  184
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  184

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  185
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  185

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Asn Val Ser Tyr Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  186
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  186

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Leu Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  187
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  187

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  188
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  188

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro 
    50                  55                  60                  


Val Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn 
65                  70                  75                  80  


Glu Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Leu Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  189
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  189

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  190
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  190

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  191
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  191

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Asn Val Ser Tyr Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  192
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  192

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Leu 
                485                 490                 495     


Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  193
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  193

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Gly Tyr His Lys Ser Gly Ala Ala Gln Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn 
                485                 490                 495     


Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  194
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  194

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys 
145                 150                 155                 160 


Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly 
                165                 170                 175     


Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala 
            180                 185                 190         


Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala 
        195                 200                 205             


Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser 
    210                 215                 220                 


Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr 
225                 230                 235                 240 


Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr 
                245                 250                 255     


Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe 
                405                 410                 415     


Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys 
        435                 440                 445             


Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val 
    450                 455                 460                 


Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly 
465                 470                 475                 480 


Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Leu 
                485                 490                 495     


Asn Ser Met Leu Ile Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn Gly 
            500                 505                 510         


Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys Glu 
        515                 520                 525             


Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile Thr 
545                 550                 555                 560 


Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr 
                565                 570                 575     


Gly Gln Val Ala Thr Asn His Gln Ala Asn Tyr Gly Gln Ala Gln Thr 
            580                 585                 590         


Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp 
                645                 650                 655     


Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Lys Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  195
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  195

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Gly Tyr His Lys Ser Gly 
        435                 440                 445             


Ala Ala Gln Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  196
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  196

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  197
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  197

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Gly Tyr His Lys Ser Gly 
        435                 440                 445             


Ala Ala Gln Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Asn Val Ser Tyr Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  198
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  198

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Leu Asn Ser Met Leu Ile Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  199
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  199

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Gly Tyr His Lys Ser Gly 
        435                 440                 445             


Ala Ala Gln Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ala Asn Tyr Gly Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  200
<211>  727
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant AAV Capsid Protein

<400>  200

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Glu Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln 
    210                 215                 220                 


Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
225                 230                 235                 240 


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser 
                245                 250                 255     


Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp 
            260                 265                 270         


Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp 
        275                 280                 285             


Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu 
    290                 295                 300                 


Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn 
305                 310                 315                 320 


Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe 
                325                 330                 335     


Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu 
            340                 345                 350         


Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr 
        355                 360                 365             


Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser 
    370                 375                 380                 


Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser 
                405                 410                 415     


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn 
        435                 440                 445             


Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val 
    450                 455                 460                 


Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val 
465                 470                 475                 480 


Ser Thr Thr Val Thr Gln Asn Leu Asn Ser Met Leu Ile Trp Pro Gly 
                485                 490                 495     


Ala Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly 
            500                 505                 510         


Pro Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu 
        515                 520                 525             


Ser Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val 
    530                 535                 540                 


Asp Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr 
545                 550                 555                 560 


Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln 
                565                 570                 575     


Ala Asn Tyr Gly Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
            580                 585                 590         


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
        595                 600                 605             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    610                 615                 620                 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
625                 630                 635                 640 


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
                645                 650                 655     


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
            660                 665                 670         


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
        675                 680                 685             


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
    690                 695                 700                 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
705                 710                 715                 720 


Arg Tyr Leu Thr Arg Asn Leu 
                725         


<210>  201
<211>  5393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rAAV vector

<400>  201
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattctcag tccattagga gccagtagcc tggaagatgt ctttaccccc      240

agcatcagtt caagtggagc agcacataac tcttgccctc tgccttccaa gattctggtg      300

ctgagactta tggagtgtct tggaggttgc cttctgcccc ccaaccctgc tcccagctgg      360

ccctcccagg cctgggttgc tggcctctgc tttatcagga ttctcaagag ggacagctgg      420

tttatgttgc atgactgttc cctgcatatc tgctctggtt ttaaatagct tatctgagca      480

gctggaggac cacatgggct tatatggcgt ggggtacatg ttcctgtagc cttgtccctg      540

gcacctgcca aaatagcagc caacaccccc cacccccacc gccatccccc tgccccaccc      600

gtcccctgtc gcacattcct ccctccgcag ggctggctca ccaggcccca gcccacatgc      660

ctgcttaaag ccctctccat cctctgcctc acccagtccc cgctgagact gagcagacgc      720

ctccaggatc tgtcggcaga agctttattg cggtagttta tcacagttaa attgctaacg      780

cagtcagtgc ttctgacaca acagtctcga acttaagctg cagaagttgg tcgtgaggca      840

ctgggcaggt aagtatcaag gttacaagac aggtttaagg agaccaatag aaactgggct      900

tgtcgagaca gagaagactc ttgcgtttct gataggcacc tattggtctt actgacatcc      960

actttgcctt tctctccaca ggtgtccact cccagttcaa ttacagctct taaggctaga     1020

gtacttaata cgactcacta taggctagcc tcgagatgga ttacaaggat gacgacgata     1080

agcctggtgt gactgttctc aagatgccgg agccagggaa gaaaccagtg tcagccttca     1140

acaagaagcc aaggtcagcg gaggtgaccg ctggcagtgc tgccgtgttc gaggctgaga     1200

cggagcggtc aggcgtgaag gtgcggtggc agcgggatgg cagcgacatc accgccaatg     1260

acaagtatgg tttggcagca gagggcaagc gacacacact gacagtgcgg gatgcgagcc     1320

ctgatgacca gggttcctac gcggtcattg caggctcctc aaaggtcaag tttgacctca     1380

aggtcacaga gccagcccct ccagagaagg cagaatctga agttgctcca ggagccccca     1440

aagaagtccc tgctccagcc actgagttgg aagaaagtgt ctcaagtcct gaagggtcag     1500

tctcggtaac ccaggatggc tcagctgcag agcatcaggg agcccctgat gaccctattg     1560

gcctctttct gatgcgacca caggatggtg aggtgaccgt gggcggcagc attgtcttct     1620

cagcccgagt ggctggggcc agcctcctga aaccgcctgt ggtcaagtgg ttcaagggca     1680

agtgggtgga cctgagcagc aaagtgggcc agcacctgca gctgcatgac agctatgaca     1740

gagccagcaa ggtctacttg tttgagttgc acatcacaga tgctcagacc acttctgctg     1800

ggggctaccg ctgtgaggtg tctaccaagg acaaatttga cagctgtaac ttcaacctca     1860

ctgtccatga ggccattggt tctggagacc tggacctcag atcagctttc cgacgcacga     1920

gcctggcggg agcaggtcgg agaaccagtg acagccatga agatgctggg actctggact     1980

ttagttccct gctgaagaag agagacagtt tccggaggga ctcaaagctg gaggcacctg     2040

ctgaagaaga cgtgtgggag atcctgagac aggcaccgcc gtcagaatat gagcgcatcg     2100

ccttccagca cggagtcaca gaccttcgag gcatgctgaa gaggctcaag ggcatgaagc     2160

aggatgaaaa gaagagcaca gcctttcaga agaagctgga gcctgcctac caggtaaaca     2220

agggccacaa gattcggctt actgtggaac tggctgatcc ggacgccgaa gtcaagtggc     2280

ttaagaatgg acaggagatc cagatgagtg gcagcaagta catcttcgag tccgtcggtg     2340

ccaagcgcac cctgaccatc agccagtgct cactggctga cgacgcagcc taccagtgtg     2400

tggtgggggg cgagaagtgc agcacggagc tctttgtcaa agagcccccg gtgctgatca     2460

ctcggtccct ggaagaccag ctggtgatgg tgggtcagcg ggtggagttt gagtgtgagg     2520

tctcagaaga aggggcccaa gtcaaatggc tgaaggatgg ggttgagctg acacgtgagg     2580

agaccttcaa ataccggttc aagaaagatg ggcggaaaca ccacttgatc atcaatgaag     2640

caaccctgga ggatgcagga cactatgcag tacgcacaag tggaggccag tcactggctg     2700

agctcattgt gcaagagaag aagttggagg tataccaaag catcgcggac ctggcagtgg     2760

gagccaagga ccaggctgtg tttaagtgtg aggtttcaga tgagaatgta cgcggcgtgt     2820

ggctgaagaa tgggaaggaa ctggtgcctg acaaccgcat aaaggtgtcc catataggcc     2880

gggtccacaa actgaccatt gacgatgtca cacctgctga tgaggctgac tacagctttg     2940

tccctgaagg gtttgcctgc aacctgtctg ccaagctcca cttcatggag gtcaagattg     3000

actttgtgcc taggcaggaa cctcccaaga tccacttgga ttgtcccggc agcacaccag     3060

acaccattgt ggttgttgct gggaacaagt tacgcctgga tgtccctatt tctggagacc     3120

ctgctcccac tgtggtctgg cagaagactg taacacaggg gaagaaggcc tcaactgggc     3180

cacaccctga tgccccagaa gatgctggtg ctgatgagga gtgggtgttt gataagaagc     3240

tgttgtgtga gactgagggc cgggtccggg tggagaccac caaagaccgc agcgtcttta     3300

cagtcgaagg ggcagagaag gaagatgaag gtgtctacac agtcacagta aagaaccccg     3360

tgggcgagga ccaggtcaac ctcacagtca aggtcatcga tgtcccagat gctcctgcgg     3420

cccctaagat cagcaacgtg ggcgaggact cctgcactgt gcagtgggaa ccgcctgcct     3480

atgatggcgg gcagccggtc ctgggataca tcctggagcg caagaagaaa aagagctaca     3540

ggtggatgag gctcaacttt gatctgctgc gggagctgag ccacgaggcg aggcgcatga     3600

tcgagggtgt agcctatgag atgcgagtct acgcagtcaa tgccgtggga atgtccaggc     3660

ccagccctgc ctctcagccc ttcatgccta ttgggccccc tggcgaacca acccacttgg     3720

ctgtggagga tgtgtcagac accactgtct cactcaagtg gcggccccca gagcgcgtgg     3780

gggccggtgg cctggacgga tacagcgtgg agtactgcca ggagggatgc tccgagtgga     3840

cacctgctct gcaggggctg acagagcgca catcgatgct ggtgaaggac ctacccactg     3900

gggcacggct gctgttccga gtacgggcac acaatgtggc aggtcctgga ggccctatcg     3960

tcaccaagga gcctgtgaca gtgcaggaga tactgcaacg accacggctc caactgccca     4020

gacacctgcg ccagaccatc cagaagaaag ttggggagcc tgtgaacctc ctcatccctt     4080

tccagggcaa accccggcct caggtgacct ggaccaaaga ggggcagccc ctggcaggtg     4140

aggaggtgag catccggaac agccccacag acacgatctt gttcatccga gctgcccgcc     4200

gcacccactc gggcacctac caggtgacag ttcgcattga gaacatggag gacaaggcaa     4260

cgctgatcct gcagattgtg gacaagccaa gtcctcccca ggatatccgg atcgttgaga     4320

cttggggttt caatgtggct ctggagtgga agccacccca agatgatggc aatacagaga     4380

tctggggtta tactgtacag aaagctgaca agaagaccat ggagtggttc acggttttgg     4440

aacactaccg acgcactcac tgtgtggtat cagagcttat cattggcaat ggctactact     4500

tccgggtctt cagccataac atggtgggtt ccagtgacaa agctgccgcc accaaggagc     4560

cagtctttat tccaagacca ggcatcacat atgagccacc caaatacaag gccctggact     4620

tctctgaggc cccaagcttc acccagccct tggcaaatcg ctccatcatt gcaggctata     4680

atgccatcct ctgctgtgct gtccgaggta gtcctaagcc caagatttcc tggttcaaga     4740

atggcctgga tctgggagaa gatgctcgct tccgcatgtt ctgcaagcag ggagtattga     4800

ccctggagat caggaaaccc tgcccctatg atggtggtgt ctatgtctgc agggccacca     4860

acttgcaggg cgaggcacag tgtgagtgcc gcctggaggt gcgagttcct cagtgaccag     4920

ggatccgtcg acgcggccgc ttccctttag tgagggttaa tgcttcgagc agacatgata     4980

agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa atgctttatt     5040

tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa taaacaagtt     5100

aacaacaaca attgcattca ttttatgttt caggttcagg gggagatgtg ggaggttttt     5160

taaagcaagt aaaacctcta caaatgtggt aaattcccga ttaggatctt cctagagcat     5220

ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg     5280

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc     5340

gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            5393


