                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
 
<120>  METHODS AND COMPOSITIONS FOR IDENTIFYING CASTRATION RESISTANT 
       NEUROENDOCRINE PROSTATE CANCER

<130>  DFS-29225

<140>  PCT/US2021/017056
<141>  2021-02-08

<150>  US 62/975,009
<151>  2020-02-11

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  2
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  2
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg     1200

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1260

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1320

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1380

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1440

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1500

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1560

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1620

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1680

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1740

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1800

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1860

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1920

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     1980

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2040

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2100

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2160

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2220

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2280

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2340

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2400

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2460

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2520

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2580

tctgaggggt g                                                          2591


<210>  3
<211>  2588
<212>  DNA
<213>  Homo sapiens

<400>  3
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggccagac      180

tgccttccgg gtcactgcca tggaggagcc gcagtcagat cctagcgtcg agccccctct      240

gagtcaggaa acattttcag acctatggaa actacttcct gaaaacaacg ttctgtcccc      300

cttgccgtcc caagcaatgg atgatttgat gctgtccccg gacgatattg aacaatggtt      360

cactgaagac ccaggtccag atgaagctcc cagaatgcca gaggctgctc cccccgtggc      420

ccctgcacca gcagctccta caccggcggc ccctgcacca gccccctcct ggcccctgtc      480

atcttctgtc ccttcccaga aaacctacca gggcagctac ggtttccgtc tgggcttctt      540

gcattctggg acagccaagt ctgtgacttg cacgtactcc cctgccctca acaagatgtt      600

ttgccaactg gccaagacct gccctgtgca gctgtgggtt gattccacac ccccgcccgg      660

cacccgcgtc cgcgccatgg ccatctacaa gcagtcacag cacatgacgg aggttgtgag      720

gcgctgcccc caccatgagc gctgctcaga tagcgatggt ctggcccctc ctcagcatct      780

tatccgagtg gaaggaaatt tgcgtgtgga gtatttggat gacagaaaca cttttcgaca      840

tagtgtggtg gtgccctatg agccgcctga ggttggctct gactgtacca ccatccacta      900

caactacatg tgtaacagtt cctgcatggg cggcatgaac cggaggccca tcctcaccat      960

catcacactg gaagactcca gtggtaatct actgggacgg aacagctttg aggtgcgtgt     1020

ttgtgcctgt cctgggagag accggcgcac agaggaagag aatctccgca agaaagggga     1080

gcctcaccac gagctgcccc cagggagcac taagcgagca ctgcccaaca acaccagctc     1140

ctctccccag ccaaagaaga aaccactgga tggagaatat ttcacccttc agatccgtgg     1200

gcgtgagcgc ttcgagatgt tccgagagct gaatgaggcc ttggaactca aggatgccca     1260

ggctgggaag gagccagggg ggagcagggc tcactccagc cacctgaagt ccaaaaaggg     1320

tcagtctacc tcccgccata aaaaactcat gttcaagaca gaagggcctg actcagactg     1380

acattctcca cttcttgttc cccactgaca gcctcccacc cccatctctc cctcccctgc     1440

cattttgggt tttgggtctt tgaacccttg cttgcaatag gtgtgcgtca gaagcaccca     1500

ggacttccat ttgctttgtc ccggggctcc actgaacaag ttggcctgca ctggtgtttt     1560

gttgtgggga ggaggatggg gagtaggaca taccagctta gattttaagg tttttactgt     1620

gagggatgtt tgggagatgt aagaaatgtt cttgcagtta agggttagtt tacaatcagc     1680

cacattctag gtaggggccc acttcaccgt actaaccagg gaagctgtcc ctcactgttg     1740

aattttctct aacttcaagg cccatatctg tgaaatgctg gcatttgcac ctacctcaca     1800

gagtgcattg tgagggttaa tgaaataatg tacatctggc cttgaaacca ccttttatta     1860

catggggtct agaacttgac ccccttgagg gtgcttgttc cctctccctg ttggtcggtg     1920

ggttggtagt ttctacagtt gggcagctgg ttaggtagag ggagttgtca agtctctgct     1980

ggcccagcca aaccctgtct gacaacctct tggtgaacct tagtacctaa aaggaaatct     2040

caccccatcc cacaccctgg aggatttcat ctcttgtata tgatgatctg gatccaccaa     2100

gacttgtttt atgctcaggg tcaatttctt ttttcttttt tttttttttt tttctttttc     2160

tttgagactg ggtctcgctt tgttgcccag gctggagtgg agtggcgtga tcttggctta     2220

ctgcagcctt tgcctccccg gctcgagcag tcctgcctca gcctccggag tagctgggac     2280

cacaggttca tgccaccatg gccagccaac ttttgcatgt tttgtagaga tggggtctca     2340

cagtgttgcc caggctggtc tcaaactcct gggctcaggc gatccacctg tctcagcctc     2400

ccagagtgct gggattacaa ttgtgagcca ccacgtccag ctggaagggt caacatcttt     2460

tacattctgc aagcacatct gcattttcac cccacccttc ccctccttct ccctttttat     2520

atcccatttt tatatcgatc tcttatttta caataaaact ttgctgccac ctgtgtgtct     2580

gaggggtg                                                              2588


<210>  4
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  5
<211>  2724
<212>  DNA
<213>  Homo sapiens

<400>  5
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcaggacca     1200

gaccagcttt caaaaagaaa attgttaaag agagcatgaa aatggttcta tgactttgcc     1260

tgatacagat gctacttgac ttacgatggt gttacttcct gataaactcg tcgtaagttg     1320

aaaatattat ccgtgggcgt gagcgcttcg agatgttccg agagctgaat gaggccttgg     1380

aactcaagga tgcccaggct gggaaggagc caggggggag cagggctcac tccagccacc     1440

tgaagtccaa aaagggtcag tctacctccc gccataaaaa actcatgttc aagacagaag     1500

ggcctgactc agactgacat tctccacttc ttgttcccca ctgacagcct cccaccccca     1560

tctctccctc ccctgccatt ttgggttttg ggtctttgaa cccttgcttg caataggtgt     1620

gcgtcagaag cacccaggac ttccatttgc tttgtcccgg ggctccactg aacaagttgg     1680

cctgcactgg tgttttgttg tggggaggag gatggggagt aggacatacc agcttagatt     1740

ttaaggtttt tactgtgagg gatgtttggg agatgtaaga aatgttcttg cagttaaggg     1800

ttagtttaca atcagccaca ttctaggtag gggcccactt caccgtacta accagggaag     1860

ctgtccctca ctgttgaatt ttctctaact tcaaggccca tatctgtgaa atgctggcat     1920

ttgcacctac ctcacagagt gcattgtgag ggttaatgaa ataatgtaca tctggccttg     1980

aaaccacctt ttattacatg gggtctagaa cttgaccccc ttgagggtgc ttgttccctc     2040

tccctgttgg tcggtgggtt ggtagtttct acagttgggc agctggttag gtagagggag     2100

ttgtcaagtc tctgctggcc cagccaaacc ctgtctgaca acctcttggt gaaccttagt     2160

acctaaaagg aaatctcacc ccatcccaca ccctggagga tttcatctct tgtatatgat     2220

gatctggatc caccaagact tgttttatgc tcagggtcaa tttctttttt cttttttttt     2280

tttttttttc tttttctttg agactgggtc tcgctttgtt gcccaggctg gagtggagtg     2340

gcgtgatctt ggcttactgc agcctttgcc tccccggctc gagcagtcct gcctcagcct     2400

ccggagtagc tgggaccaca ggttcatgcc accatggcca gccaactttt gcatgttttg     2460

tagagatggg gtctcacagt gttgcccagg ctggtctcaa actcctgggc tcaggcgatc     2520

cacctgtctc agcctcccag agtgctggga ttacaattgt gagccaccac gtccagctgg     2580

aagggtcaac atcttttaca ttctgcaagc acatctgcat tttcacccca cccttcccct     2640

ccttctccct ttttatatcc catttttata tcgatctctt attttacaat aaaactttgc     2700

tgccacctgt gtgtctgagg ggtg                                            2724


<210>  6
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  7
<211>  2651
<212>  DNA
<213>  Homo sapiens

<400>  7
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatgct     1200

acttgactta cgatggtgtt acttcctgat aaactcgtcg taagttgaaa atattatccg     1260

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1320

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1380

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1440

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1500

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1560

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1620

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1680

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1740

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1800

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1860

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1920

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1980

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     2040

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2100

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2160

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2220

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2280

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2340

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2400

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2460

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2520

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2580

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2640

tctgaggggt g                                                          2651


<210>  8
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  9
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  9
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcagatccg tgggcgtgag cgcttcgaga      900

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag      960

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc     1020

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg     1080

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt     1140

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt     1200

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat     1260

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga     1320

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg     1380

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca     1440

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt     1500

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt     1560

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca     1620

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg     1680

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc     1740

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca     1800

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg     1860

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     1920

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     1980

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2040

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2100

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2160

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2220

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g              2271


<210>  10
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  11
<211>  2404
<212>  DNA
<213>  Homo sapiens

<400>  11
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcaggacca gaccagcttt caaaaagaaa      900

attgttaaag agagcatgaa aatggttcta tgactttgcc tgatacagat gctacttgac      960

ttacgatggt gttacttcct gataaactcg tcgtaagttg aaaatattat ccgtgggcgt     1020

gagcgcttcg agatgttccg agagctgaat gaggccttgg aactcaagga tgcccaggct     1080

gggaaggagc caggggggag cagggctcac tccagccacc tgaagtccaa aaagggtcag     1140

tctacctccc gccataaaaa actcatgttc aagacagaag ggcctgactc agactgacat     1200

tctccacttc ttgttcccca ctgacagcct cccaccccca tctctccctc ccctgccatt     1260

ttgggttttg ggtctttgaa cccttgcttg caataggtgt gcgtcagaag cacccaggac     1320

ttccatttgc tttgtcccgg ggctccactg aacaagttgg cctgcactgg tgttttgttg     1380

tggggaggag gatggggagt aggacatacc agcttagatt ttaaggtttt tactgtgagg     1440

gatgtttggg agatgtaaga aatgttcttg cagttaaggg ttagtttaca atcagccaca     1500

ttctaggtag gggcccactt caccgtacta accagggaag ctgtccctca ctgttgaatt     1560

ttctctaact tcaaggccca tatctgtgaa atgctggcat ttgcacctac ctcacagagt     1620

gcattgtgag ggttaatgaa ataatgtaca tctggccttg aaaccacctt ttattacatg     1680

gggtctagaa cttgaccccc ttgagggtgc ttgttccctc tccctgttgg tcggtgggtt     1740

ggtagtttct acagttgggc agctggttag gtagagggag ttgtcaagtc tctgctggcc     1800

cagccaaacc ctgtctgaca acctcttggt gaaccttagt acctaaaagg aaatctcacc     1860

ccatcccaca ccctggagga tttcatctct tgtatatgat gatctggatc caccaagact     1920

tgttttatgc tcagggtcaa tttctttttt cttttttttt tttttttttc tttttctttg     1980

agactgggtc tcgctttgtt gcccaggctg gagtggagtg gcgtgatctt ggcttactgc     2040

agcctttgcc tccccggctc gagcagtcct gcctcagcct ccggagtagc tgggaccaca     2100

ggttcatgcc accatggcca gccaactttt gcatgttttg tagagatggg gtctcacagt     2160

gttgcccagg ctggtctcaa actcctgggc tcaggcgatc cacctgtctc agcctcccag     2220

agtgctggga ttacaattgt gagccaccac gtccagctgg aagggtcaac atcttttaca     2280

ttctgcaagc acatctgcat tttcacccca cccttcccct ccttctccct ttttatatcc     2340

catttttata tcgatctctt attttacaat aaaactttgc tgccacctgt gtgtctgagg     2400

ggtg                                                                  2404


<210>  12
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  13
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  13
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcagatgct acttgactta cgatggtgtt      900

acttcctgat aaactcgtcg taagttgaaa atattatccg tgggcgtgag cgcttcgaga      960

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag     1020

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc     1080

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg     1140

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt     1200

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt     1260

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat     1320

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga     1380

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg     1440

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca     1500

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt     1560

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt     1620

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca     1680

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg     1740

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc     1800

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca     1860

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg     1920

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     1980

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     2040

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2100

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2160

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2220

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2280

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g              2331


<210>  14
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  15
<211>  2708
<212>  DNA
<213>  Homo sapiens

<400>  15
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactgtga gtggatccat tggaagggca      300

ggcccaccac ccccacccca accccagccc cctagcagag acctgtggga agcgaaaatt      360

ccatgggact gactttctgc tcttgtcttt cagacttcct gaaaacaacg ttctgtcccc      420

cttgccgtcc caagcaatgg atgatttgat gctgtccccg gacgatattg aacaatggtt      480

cactgaagac ccaggtccag atgaagctcc cagaatgcca gaggctgctc cccccgtggc      540

ccctgcacca gcagctccta caccggcggc ccctgcacca gccccctcct ggcccctgtc      600

atcttctgtc ccttcccaga aaacctacca gggcagctac ggtttccgtc tgggcttctt      660

gcattctggg acagccaagt ctgtgacttg cacgtactcc cctgccctca acaagatgtt      720

ttgccaactg gccaagacct gccctgtgca gctgtgggtt gattccacac ccccgcccgg      780

cacccgcgtc cgcgccatgg ccatctacaa gcagtcacag cacatgacgg aggttgtgag      840

gcgctgcccc caccatgagc gctgctcaga tagcgatggt ctggcccctc ctcagcatct      900

tatccgagtg gaaggaaatt tgcgtgtgga gtatttggat gacagaaaca cttttcgaca      960

tagtgtggtg gtgccctatg agccgcctga ggttggctct gactgtacca ccatccacta     1020

caactacatg tgtaacagtt cctgcatggg cggcatgaac cggaggccca tcctcaccat     1080

catcacactg gaagactcca gtggtaatct actgggacgg aacagctttg aggtgcgtgt     1140

ttgtgcctgt cctgggagag accggcgcac agaggaagag aatctccgca agaaagggga     1200

gcctcaccac gagctgcccc cagggagcac taagcgagca ctgcccaaca acaccagctc     1260

ctctccccag ccaaagaaga aaccactgga tggagaatat ttcacccttc agatccgtgg     1320

gcgtgagcgc ttcgagatgt tccgagagct gaatgaggcc ttggaactca aggatgccca     1380

ggctgggaag gagccagggg ggagcagggc tcactccagc cacctgaagt ccaaaaaggg     1440

tcagtctacc tcccgccata aaaaactcat gttcaagaca gaagggcctg actcagactg     1500

acattctcca cttcttgttc cccactgaca gcctcccacc cccatctctc cctcccctgc     1560

cattttgggt tttgggtctt tgaacccttg cttgcaatag gtgtgcgtca gaagcaccca     1620

ggacttccat ttgctttgtc ccggggctcc actgaacaag ttggcctgca ctggtgtttt     1680

gttgtgggga ggaggatggg gagtaggaca taccagctta gattttaagg tttttactgt     1740

gagggatgtt tgggagatgt aagaaatgtt cttgcagtta agggttagtt tacaatcagc     1800

cacattctag gtaggggccc acttcaccgt actaaccagg gaagctgtcc ctcactgttg     1860

aattttctct aacttcaagg cccatatctg tgaaatgctg gcatttgcac ctacctcaca     1920

gagtgcattg tgagggttaa tgaaataatg tacatctggc cttgaaacca ccttttatta     1980

catggggtct agaacttgac ccccttgagg gtgcttgttc cctctccctg ttggtcggtg     2040

ggttggtagt ttctacagtt gggcagctgg ttaggtagag ggagttgtca agtctctgct     2100

ggcccagcca aaccctgtct gacaacctct tggtgaacct tagtacctaa aaggaaatct     2160

caccccatcc cacaccctgg aggatttcat ctcttgtata tgatgatctg gatccaccaa     2220

gacttgtttt atgctcaggg tcaatttctt ttttcttttt tttttttttt tttctttttc     2280

tttgagactg ggtctcgctt tgttgcccag gctggagtgg agtggcgtga tcttggctta     2340

ctgcagcctt tgcctccccg gctcgagcag tcctgcctca gcctccggag tagctgggac     2400

cacaggttca tgccaccatg gccagccaac ttttgcatgt tttgtagaga tggggtctca     2460

cagtgttgcc caggctggtc tcaaactcct gggctcaggc gatccacctg tctcagcctc     2520

ccagagtgct gggattacaa ttgtgagcca ccacgtccag ctggaagggt caacatcttt     2580

tacattctgc aagcacatct gcattttcac cccacccttc ccctccttct ccctttttat     2640

atcccatttt tatatcgatc tcttatttta caataaaact ttgctgccac ctgtgtgtct     2700

gaggggtg                                                              2708


<210>  16
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  16
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg     1200

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1260

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1320

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1380

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1440

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1500

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1560

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1620

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1680

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1740

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1800

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1860

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1920

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     1980

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2040

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2100

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2160

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2220

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2280

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2340

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2400

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2460

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2520

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2580

tctgaggggt g                                                          2591


<210>  17
<211>  2588
<212>  DNA
<213>  Homo sapiens

<400>  17
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggccagac      180

tgccttccgg gtcactgcca tggaggagcc gcagtcagat cctagcgtcg agccccctct      240

gagtcaggaa acattttcag acctatggaa actacttcct gaaaacaacg ttctgtcccc      300

cttgccgtcc caagcaatgg atgatttgat gctgtccccg gacgatattg aacaatggtt      360

cactgaagac ccaggtccag atgaagctcc cagaatgcca gaggctgctc cccccgtggc      420

ccctgcacca gcagctccta caccggcggc ccctgcacca gccccctcct ggcccctgtc      480

atcttctgtc ccttcccaga aaacctacca gggcagctac ggtttccgtc tgggcttctt      540

gcattctggg acagccaagt ctgtgacttg cacgtactcc cctgccctca acaagatgtt      600

ttgccaactg gccaagacct gccctgtgca gctgtgggtt gattccacac ccccgcccgg      660

cacccgcgtc cgcgccatgg ccatctacaa gcagtcacag cacatgacgg aggttgtgag      720

gcgctgcccc caccatgagc gctgctcaga tagcgatggt ctggcccctc ctcagcatct      780

tatccgagtg gaaggaaatt tgcgtgtgga gtatttggat gacagaaaca cttttcgaca      840

tagtgtggtg gtgccctatg agccgcctga ggttggctct gactgtacca ccatccacta      900

caactacatg tgtaacagtt cctgcatggg cggcatgaac cggaggccca tcctcaccat      960

catcacactg gaagactcca gtggtaatct actgggacgg aacagctttg aggtgcgtgt     1020

ttgtgcctgt cctgggagag accggcgcac agaggaagag aatctccgca agaaagggga     1080

gcctcaccac gagctgcccc cagggagcac taagcgagca ctgcccaaca acaccagctc     1140

ctctccccag ccaaagaaga aaccactgga tggagaatat ttcacccttc agatccgtgg     1200

gcgtgagcgc ttcgagatgt tccgagagct gaatgaggcc ttggaactca aggatgccca     1260

ggctgggaag gagccagggg ggagcagggc tcactccagc cacctgaagt ccaaaaaggg     1320

tcagtctacc tcccgccata aaaaactcat gttcaagaca gaagggcctg actcagactg     1380

acattctcca cttcttgttc cccactgaca gcctcccacc cccatctctc cctcccctgc     1440

cattttgggt tttgggtctt tgaacccttg cttgcaatag gtgtgcgtca gaagcaccca     1500

ggacttccat ttgctttgtc ccggggctcc actgaacaag ttggcctgca ctggtgtttt     1560

gttgtgggga ggaggatggg gagtaggaca taccagctta gattttaagg tttttactgt     1620

gagggatgtt tgggagatgt aagaaatgtt cttgcagtta agggttagtt tacaatcagc     1680

cacattctag gtaggggccc acttcaccgt actaaccagg gaagctgtcc ctcactgttg     1740

aattttctct aacttcaagg cccatatctg tgaaatgctg gcatttgcac ctacctcaca     1800

gagtgcattg tgagggttaa tgaaataatg tacatctggc cttgaaacca ccttttatta     1860

catggggtct agaacttgac ccccttgagg gtgcttgttc cctctccctg ttggtcggtg     1920

ggttggtagt ttctacagtt gggcagctgg ttaggtagag ggagttgtca agtctctgct     1980

ggcccagcca aaccctgtct gacaacctct tggtgaacct tagtacctaa aaggaaatct     2040

caccccatcc cacaccctgg aggatttcat ctcttgtata tgatgatctg gatccaccaa     2100

gacttgtttt atgctcaggg tcaatttctt ttttcttttt tttttttttt tttctttttc     2160

tttgagactg ggtctcgctt tgttgcccag gctggagtgg agtggcgtga tcttggctta     2220

ctgcagcctt tgcctccccg gctcgagcag tcctgcctca gcctccggag tagctgggac     2280

cacaggttca tgccaccatg gccagccaac ttttgcatgt tttgtagaga tggggtctca     2340

cagtgttgcc caggctggtc tcaaactcct gggctcaggc gatccacctg tctcagcctc     2400

ccagagtgct gggattacaa ttgtgagcca ccacgtccag ctggaagggt caacatcttt     2460

tacattctgc aagcacatct gcattttcac cccacccttc ccctccttct ccctttttat     2520

atcccatttt tatatcgatc tcttatttta caataaaact ttgctgccac ctgtgtgtct     2580

gaggggtg                                                              2588


<210>  18
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  19
<211>  2651
<212>  DNA
<213>  Homo sapiens

<400>  19
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatgct     1200

acttgactta cgatggtgtt acttcctgat aaactcgtcg taagttgaaa atattatccg     1260

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1320

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1380

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1440

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1500

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1560

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1620

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1680

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1740

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1800

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1860

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1920

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1980

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     2040

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2100

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2160

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2220

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2280

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2340

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2400

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2460

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2520

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2580

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2640

tctgaggggt g                                                          2651


<210>  20
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  21
<211>  2724
<212>  DNA
<213>  Homo sapiens

<400>  21
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcaggacca     1200

gaccagcttt caaaaagaaa attgttaaag agagcatgaa aatggttcta tgactttgcc     1260

tgatacagat gctacttgac ttacgatggt gttacttcct gataaactcg tcgtaagttg     1320

aaaatattat ccgtgggcgt gagcgcttcg agatgttccg agagctgaat gaggccttgg     1380

aactcaagga tgcccaggct gggaaggagc caggggggag cagggctcac tccagccacc     1440

tgaagtccaa aaagggtcag tctacctccc gccataaaaa actcatgttc aagacagaag     1500

ggcctgactc agactgacat tctccacttc ttgttcccca ctgacagcct cccaccccca     1560

tctctccctc ccctgccatt ttgggttttg ggtctttgaa cccttgcttg caataggtgt     1620

gcgtcagaag cacccaggac ttccatttgc tttgtcccgg ggctccactg aacaagttgg     1680

cctgcactgg tgttttgttg tggggaggag gatggggagt aggacatacc agcttagatt     1740

ttaaggtttt tactgtgagg gatgtttggg agatgtaaga aatgttcttg cagttaaggg     1800

ttagtttaca atcagccaca ttctaggtag gggcccactt caccgtacta accagggaag     1860

ctgtccctca ctgttgaatt ttctctaact tcaaggccca tatctgtgaa atgctggcat     1920

ttgcacctac ctcacagagt gcattgtgag ggttaatgaa ataatgtaca tctggccttg     1980

aaaccacctt ttattacatg gggtctagaa cttgaccccc ttgagggtgc ttgttccctc     2040

tccctgttgg tcggtgggtt ggtagtttct acagttgggc agctggttag gtagagggag     2100

ttgtcaagtc tctgctggcc cagccaaacc ctgtctgaca acctcttggt gaaccttagt     2160

acctaaaagg aaatctcacc ccatcccaca ccctggagga tttcatctct tgtatatgat     2220

gatctggatc caccaagact tgttttatgc tcagggtcaa tttctttttt cttttttttt     2280

tttttttttc tttttctttg agactgggtc tcgctttgtt gcccaggctg gagtggagtg     2340

gcgtgatctt ggcttactgc agcctttgcc tccccggctc gagcagtcct gcctcagcct     2400

ccggagtagc tgggaccaca ggttcatgcc accatggcca gccaactttt gcatgttttg     2460

tagagatggg gtctcacagt gttgcccagg ctggtctcaa actcctgggc tcaggcgatc     2520

cacctgtctc agcctcccag agtgctggga ttacaattgt gagccaccac gtccagctgg     2580

aagggtcaac atcttttaca ttctgcaagc acatctgcat tttcacccca cccttcccct     2640

ccttctccct ttttatatcc catttttata tcgatctctt attttacaat aaaactttgc     2700

tgccacctgt gtgtctgagg ggtg                                            2724


<210>  22
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
                165                 170                 175     


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
            180                 185                 190         


Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser 
        195                 200                 205             


His Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu 
    210                 215                 220                 


Met Phe Lys Thr Glu Gly Pro Asp Ser Asp 
225                 230                 


<210>  23
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  23
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcagatccg tgggcgtgag cgcttcgaga      900

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag      960

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc     1020

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg     1080

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt     1140

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt     1200

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat     1260

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga     1320

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg     1380

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca     1440

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt     1500

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt     1560

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca     1620

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg     1680

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc     1740

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca     1800

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg     1860

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     1920

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     1980

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2040

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2100

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2160

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2220

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g              2271


<210>  24
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser 
                165                 170                 175     


Phe Gln Lys Glu Asn Cys 
            180         


<210>  25
<211>  2404
<212>  DNA
<213>  Homo sapiens

<400>  25
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcaggacca gaccagcttt caaaaagaaa      900

attgttaaag agagcatgaa aatggttcta tgactttgcc tgatacagat gctacttgac      960

ttacgatggt gttacttcct gataaactcg tcgtaagttg aaaatattat ccgtgggcgt     1020

gagcgcttcg agatgttccg agagctgaat gaggccttgg aactcaagga tgcccaggct     1080

gggaaggagc caggggggag cagggctcac tccagccacc tgaagtccaa aaagggtcag     1140

tctacctccc gccataaaaa actcatgttc aagacagaag ggcctgactc agactgacat     1200

tctccacttc ttgttcccca ctgacagcct cccaccccca tctctccctc ccctgccatt     1260

ttgggttttg ggtctttgaa cccttgcttg caataggtgt gcgtcagaag cacccaggac     1320

ttccatttgc tttgtcccgg ggctccactg aacaagttgg cctgcactgg tgttttgttg     1380

tggggaggag gatggggagt aggacatacc agcttagatt ttaaggtttt tactgtgagg     1440

gatgtttggg agatgtaaga aatgttcttg cagttaaggg ttagtttaca atcagccaca     1500

ttctaggtag gggcccactt caccgtacta accagggaag ctgtccctca ctgttgaatt     1560

ttctctaact tcaaggccca tatctgtgaa atgctggcat ttgcacctac ctcacagagt     1620

gcattgtgag ggttaatgaa ataatgtaca tctggccttg aaaccacctt ttattacatg     1680

gggtctagaa cttgaccccc ttgagggtgc ttgttccctc tccctgttgg tcggtgggtt     1740

ggtagtttct acagttgggc agctggttag gtagagggag ttgtcaagtc tctgctggcc     1800

cagccaaacc ctgtctgaca acctcttggt gaaccttagt acctaaaagg aaatctcacc     1860

ccatcccaca ccctggagga tttcatctct tgtatatgat gatctggatc caccaagact     1920

tgttttatgc tcagggtcaa tttctttttt cttttttttt tttttttttc tttttctttg     1980

agactgggtc tcgctttgtt gcccaggctg gagtggagtg gcgtgatctt ggcttactgc     2040

agcctttgcc tccccggctc gagcagtcct gcctcagcct ccggagtagc tgggaccaca     2100

ggttcatgcc accatggcca gccaactttt gcatgttttg tagagatggg gtctcacagt     2160

gttgcccagg ctggtctcaa actcctgggc tcaggcgatc cacctgtctc agcctcccag     2220

agtgctggga ttacaattgt gagccaccac gtccagctgg aagggtcaac atcttttaca     2280

ttctgcaagc acatctgcat tttcacccca cccttcccct ccttctccct ttttatatcc     2340

catttttata tcgatctctt attttacaat aaaactttgc tgccacctgt gtgtctgagg     2400

ggtg                                                                  2404


<210>  26
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg 
1               5                   10                  15      


Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro 
            20                  25                  30          


Gln His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp 
        35                  40                  45              


Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
    50                  55                  60                  


Glu Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn 
65                  70                  75                  80  


Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
                85                  90                  95      


Thr Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu 
            100                 105                 110         


Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu 
        115                 120                 125             


Asn Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser 
    130                 135                 140                 


Thr Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp 
                165                 170                 175     


Leu Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            180                 185         


<210>  27
<211>  2331
<212>  DNA
<213>  Homo sapiens

<400>  27
tgaggccagg agatggaggc tgcagtgagc tgtgatcaca ccactgtgct ccagcctgag       60

tgacagagca agaccctatc tcaaaaaaaa aaaaaaaaaa gaaaagctcc tgaggtgtag      120

acgccaactc tctctagctc gctagtgggt tgcaggaggt gcttacgcat gtttgtttct      180

ttgctgccgt cttccagttg ctttatctgt tcacttgtgc cctgactttc aactctgtct      240

ccttcctctt cctacagtac tcccctgccc tcaacaagat gttttgccaa ctggccaaga      300

cctgccctgt gcagctgtgg gttgattcca cacccccgcc cggcacccgc gtccgcgcca      360

tggccatcta caagcagtca cagcacatga cggaggttgt gaggcgctgc ccccaccatg      420

agcgctgctc agatagcgat ggtctggccc ctcctcagca tcttatccga gtggaaggaa      480

atttgcgtgt ggagtatttg gatgacagaa acacttttcg acatagtgtg gtggtgccct      540

atgagccgcc tgaggttggc tctgactgta ccaccatcca ctacaactac atgtgtaaca      600

gttcctgcat gggcggcatg aaccggaggc ccatcctcac catcatcaca ctggaagact      660

ccagtggtaa tctactggga cggaacagct ttgaggtgcg tgtttgtgcc tgtcctggga      720

gagaccggcg cacagaggaa gagaatctcc gcaagaaagg ggagcctcac cacgagctgc      780

ccccagggag cactaagcga gcactgccca acaacaccag ctcctctccc cagccaaaga      840

agaaaccact ggatggagaa tatttcaccc ttcagatgct acttgactta cgatggtgtt      900

acttcctgat aaactcgtcg taagttgaaa atattatccg tgggcgtgag cgcttcgaga      960

tgttccgaga gctgaatgag gccttggaac tcaaggatgc ccaggctggg aaggagccag     1020

gggggagcag ggctcactcc agccacctga agtccaaaaa gggtcagtct acctcccgcc     1080

ataaaaaact catgttcaag acagaagggc ctgactcaga ctgacattct ccacttcttg     1140

ttccccactg acagcctccc acccccatct ctccctcccc tgccattttg ggttttgggt     1200

ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac ccaggacttc catttgcttt     1260

gtcccggggc tccactgaac aagttggcct gcactggtgt tttgttgtgg ggaggaggat     1320

ggggagtagg acataccagc ttagatttta aggtttttac tgtgagggat gtttgggaga     1380

tgtaagaaat gttcttgcag ttaagggtta gtttacaatc agccacattc taggtagggg     1440

cccacttcac cgtactaacc agggaagctg tccctcactg ttgaattttc tctaacttca     1500

aggcccatat ctgtgaaatg ctggcatttg cacctacctc acagagtgca ttgtgagggt     1560

taatgaaata atgtacatct ggccttgaaa ccacctttta ttacatgggg tctagaactt     1620

gacccccttg agggtgcttg ttccctctcc ctgttggtcg gtgggttggt agtttctaca     1680

gttgggcagc tggttaggta gagggagttg tcaagtctct gctggcccag ccaaaccctg     1740

tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa tctcacccca tcccacaccc     1800

tggaggattt catctcttgt atatgatgat ctggatccac caagacttgt tttatgctca     1860

gggtcaattt cttttttctt tttttttttt ttttttcttt ttctttgaga ctgggtctcg     1920

ctttgttgcc caggctggag tggagtggcg tgatcttggc ttactgcagc ctttgcctcc     1980

ccggctcgag cagtcctgcc tcagcctccg gagtagctgg gaccacaggt tcatgccacc     2040

atggccagcc aacttttgca tgttttgtag agatggggtc tcacagtgtt gcccaggctg     2100

gtctcaaact cctgggctca ggcgatccac ctgtctcagc ctcccagagt gctgggatta     2160

caattgtgag ccaccacgtc cagctggaag ggtcaacatc ttttacattc tgcaagcaca     2220

tctgcatttt caccccaccc ttcccctcct tctccctttt tatatcccat ttttatatcg     2280

atctcttatt ttacaataaa actttgctgc cacctgtgtg tctgaggggt g              2331


<210>  28
<211>  381
<212>  PRT
<213>  Mus musculus

<400>  28

Met Thr Ala Met Glu Glu Ser Gln Ser Asp Ile Ser Leu Glu Leu Pro 
1               5                   10                  15      


Leu Ser Gln Glu Thr Phe Ser Gly Leu Trp Lys Leu Leu Pro Pro Glu 
            20                  25                  30          


Asp Ile Leu Pro Ser Pro His Cys Met Asp Asp Leu Leu Leu Pro Gln 
        35                  40                  45              


Asp Val Glu Glu Phe Phe Glu Gly Pro Ser Glu Ala Leu Arg Val Ser 
    50                  55                  60                  


Gly Ala Pro Ala Ala Gln Asp Pro Val Thr Glu Thr Pro Gly Pro Val 
65                  70                  75                  80  


Ala Pro Ala Pro Ala Thr Pro Trp Pro Leu Ser Ser Phe Val Pro Ser 
                85                  90                  95      


Gln Lys Thr Tyr Gln Gly Asn Tyr Gly Phe His Leu Gly Phe Leu Gln 
            100                 105                 110         


Ser Gly Thr Ala Lys Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asn 
        115                 120                 125             


Lys Leu Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val 
    130                 135                 140                 


Ser Ala Thr Pro Pro Ala Gly Ser Arg Val Arg Ala Met Ala Ile Tyr 
145                 150                 155                 160 


Lys Lys Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His 
                165                 170                 175     


Glu Arg Cys Ser Asp Gly Asp Gly Leu Ala Pro Pro Gln His Leu Ile 
            180                 185                 190         


Arg Val Glu Gly Asn Leu Tyr Pro Glu Tyr Leu Glu Asp Arg Gln Thr 
        195                 200                 205             


Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Ala Gly Ser 
    210                 215                 220                 


Glu Tyr Thr Thr Ile His Tyr Lys Tyr Met Cys Asn Ser Ser Cys Met 
225                 230                 235                 240 


Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp 
                245                 250                 255     


Ser Ser Gly Asn Leu Leu Gly Arg Asp Ser Phe Glu Val Arg Val Cys 
            260                 265                 270         


Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Phe Arg Lys 
        275                 280                 285             


Lys Glu Val Leu Cys Pro Glu Leu Pro Pro Gly Ser Ala Lys Arg Ala 
    290                 295                 300                 


Leu Pro Thr Cys Thr Ser Ala Ser Pro Pro Gln Lys Lys Lys Pro Leu 
305                 310                 315                 320 


Asp Gly Glu Tyr Phe Thr Leu Lys Ile Arg Gly Arg Lys Arg Phe Glu 
                325                 330                 335     


Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala His Ala 
            340                 345                 350         


Thr Glu Glu Ser Gly Asp Ser Arg Ala His Ser Ser Leu Gln Pro Arg 
        355                 360                 365             


Ala Phe Gln Ala Leu Ile Lys Glu Glu Ser Pro Asn Cys 
    370                 375                 380     


<210>  29
<211>  1877
<212>  DNA
<213>  Mus musculus

<400>  29
tttcccctcc cacgtgctca ccctggctaa agttctgtag cttcagttca ttgggaccat       60

cctggctgta ggtagcgact acagttaggg ggcacctagc attcaggccc tcatcctcct      120

ccttcccagc agggtgtcac gcttctccga agactggatg actgccatgg aggagtcaca      180

gtcggatatc agcctcgagc tccctctgag ccaggagaca ttttcaggct tatggaaact      240

acttcctcca gaagatatcc tgccatcacc tcactgcatg gacgatctgt tgctgcccca      300

ggatgttgag gagttttttg aaggcccaag tgaagccctc cgagtgtcag gagctcctgc      360

agcacaggac cctgtcaccg agacccctgg gccagtggcc cctgccccag ccactccatg      420

gcccctgtca tcttttgtcc cttctcaaaa aacttaccag ggcaactatg gcttccacct      480

gggcttcctg cagtctggga cagccaagtc tgttatgtgc acgtactctc ctcccctcaa      540

taagctattc tgccagctgg cgaagacgtg ccctgtgcag ttgtgggtca gcgccacacc      600

tccagctggg agccgtgtcc gcgccatggc catctacaag aagtcacagc acatgacgga      660

ggtcgtgaga cgctgccccc accatgagcg ctgctccgat ggtgatggcc tggctcctcc      720

ccagcatctt atccgggtgg aaggaaattt gtatcccgag tatctggaag acaggcagac      780

ttttcgccac agcgtggtgg taccttatga gccacccgag gccggctctg agtataccac      840

catccactac aagtacatgt gtaatagctc ctgcatgggg ggcatgaacc gccgacctat      900

ccttaccatc atcacactgg aagactccag tgggaacctt ctgggacggg acagctttga      960

ggttcgtgtt tgtgcctgcc ctgggagaga ccgccgtaca gaagaagaaa atttccgcaa     1020

aaaggaagtc ctttgccctg aactgccccc agggagcgca aagagagcgc tgcccacctg     1080

cacaagcgcc tctcccccgc aaaagaaaaa accacttgat ggagagtatt tcaccctcaa     1140

gatccgcggg cgtaaacgct tcgagatgtt ccgggagctg aatgaggcct tagagttaaa     1200

ggatgcccat gctacagagg agtctggaga cagcagggct cactccagcc tccagcctag     1260

agccttccaa gccttgatca aggaggaaag cccaaactgc tagctcccat cacttcatcc     1320

ctcccctttt ctgtcttcct atagctacct gaagaccaag aagggccagt ctacttcccg     1380

ccataaaaaa acaatggtca agaaagtggg gcctgactca gactgactgc ctctgcatcc     1440

cgtccccatc accagcctcc ccctctcctt gctgtcttat gacttcaggg ctgagacaca     1500

atcctcccgg tcccttctgc tgcctttttt accttgtagc tagggctcag ccccctctct     1560

gagtagtggt tcctggccca agttggggaa taggttgata gttgtcaggt ctctgctggc     1620

ccagcgaaat tctatccagc cagttgttgg accctggcac ctacaatgaa atctcaccct     1680

accccacacc ctgtaagatt ctatcttggg ccctcatagg gtccatatcc tccagggcct     1740

actttccttc cattctgcaa agcctgtctg catttatcca ccccccaccc tgtctccctc     1800

tttttttttt ttttacccct ttttatatat caatttccta ttttacaata aaattttgtt     1860

atcacttaaa aaaaaaa                                                    1877


<210>  30
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  30

Met Thr Ala Met Glu Glu Ser Gln Ser Asp Ile Ser Leu Glu Leu Pro 
1               5                   10                  15      


Leu Ser Gln Glu Thr Phe Ser Gly Leu Trp Lys Leu Leu Pro Pro Glu 
            20                  25                  30          


Asp Ile Leu Pro Ser Pro His Cys Met Asp Asp Leu Leu Leu Pro Gln 
        35                  40                  45              


Asp Val Glu Glu Phe Phe Glu Gly Pro Ser Glu Ala Leu Arg Val Ser 
    50                  55                  60                  


Gly Ala Pro Ala Ala Gln Asp Pro Val Thr Glu Thr Pro Gly Pro Val 
65                  70                  75                  80  


Ala Pro Ala Pro Ala Thr Pro Trp Pro Leu Ser Ser Phe Val Pro Ser 
                85                  90                  95      


Gln Lys Thr Tyr Gln Gly Asn Tyr Gly Phe His Leu Gly Phe Leu Gln 
            100                 105                 110         


Ser Gly Thr Ala Lys Ser Val Met Cys Thr Tyr Ser Pro Pro Leu Asn 
        115                 120                 125             


Lys Leu Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val 
    130                 135                 140                 


Ser Ala Thr Pro Pro Ala Gly Ser Arg Val Arg Ala Met Ala Ile Tyr 
145                 150                 155                 160 


Lys Lys Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His 
                165                 170                 175     


Glu Arg Cys Ser Asp Gly Asp Gly Leu Ala Pro Pro Gln His Leu Ile 
            180                 185                 190         


Arg Val Glu Gly Asn Leu Tyr Pro Glu Tyr Leu Glu Asp Arg Gln Thr 
        195                 200                 205             


Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Ala Gly Ser 
    210                 215                 220                 


Glu Tyr Thr Thr Ile His Tyr Lys Tyr Met Cys Asn Ser Ser Cys Met 
225                 230                 235                 240 


Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp 
                245                 250                 255     


Ser Ser Gly Asn Leu Leu Gly Arg Asp Ser Phe Glu Val Arg Val Cys 
            260                 265                 270         


Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Phe Arg Lys 
        275                 280                 285             


Lys Glu Val Leu Cys Pro Glu Leu Pro Pro Gly Ser Ala Lys Arg Ala 
    290                 295                 300                 


Leu Pro Thr Cys Thr Ser Ala Ser Pro Pro Gln Lys Lys Lys Pro Leu 
305                 310                 315                 320 


Asp Gly Glu Tyr Phe Thr Leu Lys Ile Arg Gly Arg Lys Arg Phe Glu 
                325                 330                 335     


Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala His Ala 
            340                 345                 350         


Thr Glu Glu Ser Gly Asp Ser Arg Ala His Ser Ser Tyr Leu Lys Thr 
        355                 360                 365             


Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Thr Met Val Lys Lys 
    370                 375                 380                 


Val Gly Pro Asp Ser Asp 
385                 390 


<210>  31
<211>  1781
<212>  DNA
<213>  Mus musculus

<400>  31
tttcccctcc cacgtgctca ccctggctaa agttctgtag cttcagttca ttgggaccat       60

cctggctgta ggtagcgact acagttaggg ggcacctagc attcaggccc tcatcctcct      120

ccttcccagc agggtgtcac gcttctccga agactggatg actgccatgg aggagtcaca      180

gtcggatatc agcctcgagc tccctctgag ccaggagaca ttttcaggct tatggaaact      240

acttcctcca gaagatatcc tgccatcacc tcactgcatg gacgatctgt tgctgcccca      300

ggatgttgag gagttttttg aaggcccaag tgaagccctc cgagtgtcag gagctcctgc      360

agcacaggac cctgtcaccg agacccctgg gccagtggcc cctgccccag ccactccatg      420

gcccctgtca tcttttgtcc cttctcaaaa aacttaccag ggcaactatg gcttccacct      480

gggcttcctg cagtctggga cagccaagtc tgttatgtgc acgtactctc ctcccctcaa      540

taagctattc tgccagctgg cgaagacgtg ccctgtgcag ttgtgggtca gcgccacacc      600

tccagctggg agccgtgtcc gcgccatggc catctacaag aagtcacagc acatgacgga      660

ggtcgtgaga cgctgccccc accatgagcg ctgctccgat ggtgatggcc tggctcctcc      720

ccagcatctt atccgggtgg aaggaaattt gtatcccgag tatctggaag acaggcagac      780

ttttcgccac agcgtggtgg taccttatga gccacccgag gccggctctg agtataccac      840

catccactac aagtacatgt gtaatagctc ctgcatgggg ggcatgaacc gccgacctat      900

ccttaccatc atcacactgg aagactccag tgggaacctt ctgggacggg acagctttga      960

ggttcgtgtt tgtgcctgcc ctgggagaga ccgccgtaca gaagaagaaa atttccgcaa     1020

aaaggaagtc ctttgccctg aactgccccc agggagcgca aagagagcgc tgcccacctg     1080

cacaagcgcc tctcccccgc aaaagaaaaa accacttgat ggagagtatt tcaccctcaa     1140

gatccgcggg cgtaaacgct tcgagatgtt ccgggagctg aatgaggcct tagagttaaa     1200

ggatgcccat gctacagagg agtctggaga cagcagggct cactccagct acctgaagac     1260

caagaagggc cagtctactt cccgccataa aaaaacaatg gtcaagaaag tggggcctga     1320

ctcagactga ctgcctctgc atcccgtccc catcaccagc ctccccctct ccttgctgtc     1380

ttatgacttc agggctgaga cacaatcctc ccggtccctt ctgctgcctt ttttaccttg     1440

tagctagggc tcagccccct ctctgagtag tggttcctgg cccaagttgg ggaataggtt     1500

gatagttgtc aggtctctgc tggcccagcg aaattctatc cagccagttg ttggaccctg     1560

gcacctacaa tgaaatctca ccctacccca caccctgtaa gattctatct tgggccctca     1620

tagggtccat atcctccagg gcctactttc cttccattct gcaaagcctg tctgcattta     1680

tccacccccc accctgtctc cctctttttt ttttttttac ccctttttat atatcaattt     1740

cctattttac aataaaattt tgttatcact taaaaaaaaa a                         1781


<210>  32
<211>  928
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
        35                  40                  45              


Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
    50                  55                  60                  


Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
65                  70                  75                  80  


Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                85                  90                  95      


Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
            100                 105                 110         


Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
        115                 120                 125             


His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
    130                 135                 140                 


Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
145                 150                 155                 160 


Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                165                 170                 175     


Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
            180                 185                 190         


Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
        195                 200                 205             


Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
    210                 215                 220                 


Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
225                 230                 235                 240 


Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 
                245                 250                 255     


Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
            260                 265                 270         


Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
        275                 280                 285             


Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
    290                 295                 300                 


Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
305                 310                 315                 320 


Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                325                 330                 335     


Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
            340                 345                 350         


Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
        355                 360                 365             


Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
    370                 375                 380                 


Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
385                 390                 395                 400 


Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                405                 410                 415     


Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
            420                 425                 430         


Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
        435                 440                 445             


Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
    450                 455                 460                 


Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
465                 470                 475                 480 


Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                485                 490                 495     


Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
            500                 505                 510         


Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
        515                 520                 525             


Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
    530                 535                 540                 


Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
545                 550                 555                 560 


Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                565                 570                 575     


Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
            580                 585                 590         


Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
        595                 600                 605             


Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
    610                 615                 620                 


Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                645                 650                 655     


Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
            660                 665                 670         


His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
        675                 680                 685             


Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
    690                 695                 700                 


Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
705                 710                 715                 720 


Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                725                 730                 735     


Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
            740                 745                 750         


Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
        755                 760                 765             


Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
    770                 775                 780                 


Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
785                 790                 795                 800 


Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 
                805                 810                 815     


Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 
            820                 825                 830         


Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
        835                 840                 845             


Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
    850                 855                 860                 


Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
865                 870                 875                 880 


Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                885                 890                 895     


Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
            900                 905                 910         


Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
        915                 920                 925             


<210>  33
<211>  4772
<212>  DNA
<213>  Homo sapiens

<400>  33
gctcagttgc cgggcggggg agggcgcgtc cggtttttct caggggacgt tgaaattatt       60

tttgtaacgg gagtcgggag aggacggggc gtgccccgac gtgcgcgcgc gtcgtcctcc      120

ccggcgctcc tccacagctc gctggctccc gccgcggaaa ggcgtcatgc cgcccaaaac      180

cccccgaaaa acggccgcca ccgccgccgc tgccgccgcg gaacccccgg caccgccgcc      240

gccgccccct cctgaggagg acccagagca ggacagcggc ccggaggacc tgcctctcgt      300

caggcttgag tttgaagaaa cagaagaacc tgattttact gcattatgtc agaaattaaa      360

gataccagat catgtcagag agagagcttg gttaacttgg gagaaagttt catctgtgga      420

tggagtattg ggaggttata ttcaaaagaa aaaggaactg tggggaatct gtatctttat      480

tgcagcagtt gacctagatg agatgtcgtt cacttttact gagctacaga aaaacataga      540

aatcagtgtc cataaattct ttaacttact aaaagaaatt gataccagta ccaaagttga      600

taatgctatg tcaagactgt tgaagaagta tgatgtattg tttgcactct tcagcaaatt      660

ggaaaggaca tgtgaactta tatatttgac acaacccagc agttcgatat ctactgaaat      720

aaattctgca ttggtgctaa aagtttcttg gatcacattt ttattagcta aaggggaagt      780

attacaaatg gaagatgatc tggtgatttc atttcagtta atgctatgtg tccttgacta      840

ttttattaaa ctctcacctc ccatgttgct caaagaacca tataaaacag ctgttatacc      900

cattaatggt tcacctcgaa cacccaggcg aggtcagaac aggagtgcac ggatagcaaa      960

acaactagaa aatgatacaa gaattattga agttctctgt aaagaacatg aatgtaatat     1020

agatgaggtg aaaaatgttt atttcaaaaa ttttatacct tttatgaatt ctcttggact     1080

tgtaacatct aatggacttc cagaggttga aaatctttct aaacgatacg aagaaattta     1140

tcttaaaaat aaagatctag atgcaagatt atttttggat catgataaaa ctcttcagac     1200

tgattctata gacagttttg aaacacagag aacaccacga aaaagtaacc ttgatgaaga     1260

ggtgaatgta attcctccac acactccagt taggactgtt atgaacacta tccaacaatt     1320

aatgatgatt ttaaattcag caagtgatca accttcagaa aatctgattt cctattttaa     1380

caactgcaca gtgaatccaa aagaaagtat actgaaaaga gtgaaggata taggatacat     1440

ctttaaagag aaatttgcta aagctgtggg acagggttgt gtcgaaattg gatcacagcg     1500

atacaaactt ggagttcgct tgtattaccg agtaatggaa tccatgctta aatcagaaga     1560

agaacgatta tccattcaaa attttagcaa acttctgaat gacaacattt ttcatatgtc     1620

tttattggcg tgcgctcttg aggttgtaat ggccacatat agcagaagta catctcagaa     1680

tcttgattct ggaacagatt tgtctttccc atggattctg aatgtgctta atttaaaagc     1740

ctttgatttt tacaaagtga tcgaaagttt tatcaaagca gaaggcaact tgacaagaga     1800

aatgataaaa catttagaac gatgtgaaca tcgaatcatg gaatcccttg catggctctc     1860

agattcacct ttatttgatc ttattaaaca atcaaaggac cgagaaggac caactgatca     1920

ccttgaatct gcttgtcctc ttaatcttcc tctccagaat aatcacactg cagcagatat     1980

gtatctttct cctgtaagat ctccaaagaa aaaaggttca actacgcgtg taaattctac     2040

tgcaaatgca gagacacaag caacctcagc cttccagacc cagaagccat tgaaatctac     2100

ctctctttca ctgttttata aaaaagtgta tcggctagcc tatctccggc taaatacact     2160

ttgtgaacgc cttctgtctg agcacccaga attagaacat atcatctgga cccttttcca     2220

gcacaccctg cagaatgagt atgaactcat gagagacagg catttggacc aaattatgat     2280

gtgttccatg tatggcatat gcaaagtgaa gaatatagac cttaaattca aaatcattgt     2340

aacagcatac aaggatcttc ctcatgctgt tcaggagaca ttcaaacgtg ttttgatcaa     2400

agaagaggag tatgattcta ttatagtatt ctataactcg gtcttcatgc agagactgaa     2460

aacaaatatt ttgcagtatg cttccaccag gccccctacc ttgtcaccaa tacctcacat     2520

tcctcgaagc ccttacaagt ttcctagttc acccttacgg attcctggag ggaacatcta     2580

tatttcaccc ctgaagagtc catataaaat ttcagaaggt ctgccaacac caacaaaaat     2640

gactccaaga tcaagaatct tagtatcaat tggtgaatca ttcgggactt ctgagaagtt     2700

ccagaaaata aatcagatgg tatgtaacag cgaccgtgtg ctcaaaagaa gtgctgaagg     2760

aagcaaccct cctaaaccac tgaaaaaact acgctttgat attgaaggat cagatgaagc     2820

agatggaagt aaacatctcc caggagagtc caaatttcag cagaaactgg cagaaatgac     2880

ttctactcga acacgaatgc aaaagcagaa aatgaatgat agcatggata cctcaaacaa     2940

ggaagagaaa tgaggatctc aggaccttgg tggacactgt gtacacctct ggattcattg     3000

tctctcacag atgtgactgt ataactttcc caggttctgt ttatggccac atttaatatc     3060

ttcagctctt tttgtggata taaaatgtgc agatgcaatt gtttgggtga ttcctaagcc     3120

acttgaaatg ttagtcattg ttatttatac aagattgaaa atcttgtgta aatcctgcca     3180

tttaaaaagt tgtagcagat tgtttcctct tccaaagtaa aattgctgtg ctttatggat     3240

agtaagaatg gccctagagt gggagtcctg ataacccagg cctgtctgac tactttgcct     3300

tcttttgtag catataggtg atgtttgctc ttgtttttat taatttatat gtatattttt     3360

ttaatttaac atgaacaccc ttagaaaatg tgtcctatct atcttccaaa tgcaatttga     3420

ttgactgccc attcaccaaa attatcctga actcttctgc aaaaatggat attattagaa     3480

attagaaaaa aattactaat tttacacatt agattttatt ttactattgg aatctgatat     3540

actgtgtgct tgttttataa aattttgctt ttaattaaat aaaagctgga agcaaagtat     3600

aaccatatga tactatcata ctactgaaac agatttcata cctcagaatg taaaagaact     3660

tactgattat tttcttcatc caacttatgt ttttaaatga ggattattga tagtactctt     3720

ggtttttata ccattcagat cactgaattt ataaagtacc catctagtac ttgaaaaagt     3780

aaagtgttct gccagatctt aggtatagag gaccctaaca cagtatatcc caagtgcact     3840

ttctaatgtt tctgggtcct gaagaattaa gatacaaatt aattttactc cataaacaga     3900

ctgttaatta taggagcctt aatttttttt tcatagagat ttgtctaatt gcatctcaaa     3960

attattctgc cctccttaat ttgggaaggt ttgtgttttc tctggaatgg tacatgtctt     4020

ccatgtatct tttgaactgg caattgtcta tttatctttt atttttttaa gtcagtatgg     4080

tctaacactg gcatgttcaa agccacatta tttctagtcc aaaattacaa gtaatcaagg     4140

gtcattatgg gttaggcatt aatgtttcta tctgattttg tgcaaaagct tcaaattaaa     4200

acagctgcat tagaaaaaga ggcgcttctc ccctccccta cacctaaagg tgtatttaaa     4260

ctatcttgtg tgattaactt atttagagat gctgtaactt aaaatagggg atatttaagg     4320

tagcttcagc tagcttttag gaaaatcact ttgtctaact cagaattatt tttaaaaaga     4380

aatctggtct tgttagaaaa caaaatttta ttttgtgctc atttaagttt caaacttact     4440

attttgacag ttattttgat aacaatgaca ctagaaaact tgactccatt tcatcattgt     4500

ttctgcatga atatcataca aatcagttag tttttaggtc aagggcttac tatttctggg     4560

tcttttgcta ctaagttcac attagaatta gtgccagaat tttaggaact tcagagatcg     4620

tgtattgaga tttcttaaat aatgcttcag atattattgc tttattgctt ttttgtattg     4680

gttaaaactg tacatttaaa attgctatgt tactattttc tacaattaat agtttgtcta     4740

ttttaaaata aattagttgt taagagtctt aa                                   4772


<210>  34
<211>  921
<212>  PRT
<213>  Mus musculus

<400>  34

Met Pro Pro Lys Ala Pro Arg Arg Ala Ala Ala Ala Glu Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Arg Glu Asp Asp Pro Ala Gln Asp Ser Gly 
            20                  25                  30          


Pro Glu Glu Leu Pro Leu Ala Arg Leu Glu Phe Glu Glu Ile Glu Glu 
        35                  40                  45              


Pro Glu Phe Ile Ala Leu Cys Gln Lys Leu Lys Val Pro Asp His Val 
    50                  55                  60                  


Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys Val Ser Ser Val Asp Gly 
65                  70                  75                  80  


Ile Leu Glu Gly Tyr Ile Gln Lys Lys Lys Glu Leu Trp Gly Ile Cys 
                85                  90                  95      


Ile Phe Ile Ala Ala Val Asp Leu Asp Glu Met Pro Phe Thr Phe Thr 
            100                 105                 110         


Glu Leu Gln Lys Ser Ile Glu Thr Ser Val Tyr Lys Phe Phe Asp Leu 
        115                 120                 125             


Leu Lys Glu Ile Asp Thr Ser Thr Lys Val Asp Asn Ala Met Ser Arg 
    130                 135                 140                 


Leu Leu Lys Lys Tyr Asn Val Leu Cys Ala Leu Tyr Ser Lys Leu Glu 
145                 150                 155                 160 


Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln Pro Ser Ser Ala Leu Ser 
                165                 170                 175     


Thr Glu Ile Asn Ser Met Leu Val Leu Lys Ile Ser Trp Ile Thr Phe 
            180                 185                 190         


Leu Leu Ala Lys Gly Glu Val Leu Gln Met Glu Asp Asp Leu Val Ile 
        195                 200                 205             


Ser Phe Gln Leu Met Leu Cys Val Val Asp Tyr Phe Ile Lys Phe Ser 
    210                 215                 220                 


Pro Pro Ala Leu Leu Arg Glu Pro Tyr Lys Thr Ala Ala Ile Pro Ile 
225                 230                 235                 240 


Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly Gln Asn Arg Ser Ala Arg 
                245                 250                 255     


Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg Ile Ile Glu Val Leu Cys 
            260                 265                 270         


Lys Glu His Glu Cys Asn Ile Asp Glu Val Lys Asn Val Tyr Phe Lys 
        275                 280                 285             


Asn Phe Ile Pro Phe Ile Asn Ser Leu Gly Ile Val Ser Ser Asn Gly 
    290                 295                 300                 


Leu Pro Glu Val Glu Ser Leu Ser Lys Arg Tyr Glu Glu Val Tyr Leu 
305                 310                 315                 320 


Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe Leu Asp His Asp Lys Thr 
                325                 330                 335     


Leu Gln Thr Asp Pro Ile Asp Ser Phe Glu Thr Glu Arg Thr Pro Arg 
            340                 345                 350         


Lys Asn Asn Pro Asp Glu Glu Ala Asn Val Val Thr Pro His Thr Pro 
        355                 360                 365             


Val Arg Thr Val Met Asn Thr Ile Gln Gln Leu Met Val Ile Leu Asn 
    370                 375                 380                 


Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu Ile Ser Tyr Phe Asn Asn 
385                 390                 395                 400 


Cys Thr Val Asn Pro Lys Glu Asn Ile Leu Lys Arg Val Lys Asp Val 
                405                 410                 415     


Gly His Ile Phe Lys Glu Lys Phe Ala Asn Ala Val Gly Gln Gly Cys 
            420                 425                 430         


Val Asp Ile Gly Val Gln Arg Tyr Lys Leu Gly Val Arg Leu Tyr Tyr 
        435                 440                 445             


Arg Val Met Glu Ser Met Leu Lys Ser Glu Glu Glu Arg Leu Ser Ile 
    450                 455                 460                 


Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn Ile Phe His Met Ser Leu 
465                 470                 475                 480 


Leu Ala Cys Ala Leu Glu Val Val Met Ala Thr Tyr Ser Arg Ser Thr 
                485                 490                 495     


Leu Gln His Leu Asp Ser Gly Thr Asp Leu Ser Phe Pro Trp Ile Leu 
            500                 505                 510         


Asn Val Leu Asn Leu Lys Ala Phe Asp Phe Tyr Lys Val Ile Glu Ser 
        515                 520                 525             


Phe Ile Lys Val Glu Ala Asn Leu Thr Arg Glu Met Ile Lys His Leu 
    530                 535                 540                 


Glu Arg Cys Glu His Arg Ile Met Glu Ser Leu Ala Trp Leu Ser Asp 
545                 550                 555                 560 


Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser Lys Asp Gly Glu Gly Pro 
                565                 570                 575     


Asp Asn Leu Glu Pro Ala Cys Pro Leu Ser Leu Pro Leu Gln Gly Asn 
            580                 585                 590         


His Thr Ala Ala Asp Met Tyr Leu Ser Pro Leu Arg Ser Pro Lys Lys 
        595                 600                 605             


Arg Thr Ser Thr Thr Arg Val Asn Ser Ala Ala Asn Thr Glu Thr Gln 
    610                 615                 620                 


Ala Ala Ser Ala Phe His Thr Gln Lys Pro Leu Lys Ser Thr Ser Leu 
625                 630                 635                 640 


Ala Leu Phe Tyr Lys Lys Val Tyr Arg Leu Ala Tyr Leu Arg Leu Asn 
                645                 650                 655     


Thr Leu Cys Ala Arg Leu Leu Ser Asp His Pro Glu Leu Glu His Ile 
            660                 665                 670         


Ile Trp Thr Leu Phe Gln His Thr Leu Gln Asn Glu Tyr Glu Leu Met 
        675                 680                 685             


Arg Asp Arg His Leu Asp Gln Ile Met Met Cys Ser Met Tyr Gly Ile 
    690                 695                 700                 


Cys Lys Val Lys Asn Ile Asp Leu Lys Phe Lys Ile Ile Val Thr Ala 
705                 710                 715                 720 


Tyr Lys Asp Leu Pro His Ala Ala Gln Glu Thr Phe Lys Arg Val Leu 
                725                 730                 735     


Ile Arg Glu Glu Glu Phe Asp Ser Ile Ile Val Phe Tyr Asn Ser Val 
            740                 745                 750         


Phe Met Gln Arg Leu Lys Thr Asn Ile Leu Gln Tyr Ala Ser Thr Arg 
        755                 760                 765             


Pro Pro Thr Leu Ser Pro Ile Pro His Ile Pro Arg Ser Pro Tyr Lys 
    770                 775                 780                 


Phe Ser Ser Ser Pro Leu Arg Ile Pro Gly Gly Asn Ile Tyr Ile Ser 
785                 790                 795                 800 


Pro Leu Lys Ser Pro Tyr Lys Ile Ser Glu Gly Leu Pro Thr Pro Thr 
                805                 810                 815     


Lys Met Thr Pro Arg Ser Arg Ile Leu Val Ser Ile Gly Glu Ser Phe 
            820                 825                 830         


Gly Thr Ser Glu Lys Phe Gln Lys Ile Asn Gln Met Val Cys Asn Ser 
        835                 840                 845             


Asp Arg Val Leu Lys Arg Ser Ala Glu Gly Gly Asn Pro Pro Lys Pro 
    850                 855                 860                 


Leu Lys Lys Leu Arg Phe Asp Ile Glu Gly Ala Asp Glu Ala Asp Gly 
865                 870                 875                 880 


Ser Lys His Leu Pro Ala Glu Ser Lys Phe Gln Gln Lys Leu Ala Glu 
                885                 890                 895     


Met Thr Ser Thr Arg Thr Arg Met Gln Lys Gln Arg Met Asn Glu Ser 
            900                 905                 910         


Lys Asp Val Ser Asn Lys Glu Glu Lys 
        915                 920     


<210>  35
<211>  4673
<212>  DNA
<213>  Mus musculus

<400>  35
gttttcccgc ggttggcccg ggcgctcggt tgccgggcgc gtccggtttt cctcggggga       60

cgttcccatt atttttgtaa cgggagtcgg gtgaggacgg ggcgtgcccg gcgtgcgcgc      120

gcgcccgccc gcctccccgc gcgcctccct cggctgctcg cgccggcccg cgctgcgcgt      180

catgccgccc aaagccccgc gcagagccgc ggccgccgag cccccgccac cgccgccgcc      240

gccgcctcgg gaggacgacc ccgcgcagga cagcggcccc gaagagctgc ccctggccag      300

gcttgagttt gaagaaattg aagaacccga atttattgca ttatgtcaaa agttaaaggt      360

acccgatcat gtcagagaaa gagcttggct aacttgggag aaagtttcat ccgtggatgg      420

aatcctggaa ggatatattc aaaagaagaa ggaactctgg ggcatctgca tctttatcgc      480

agcagttgat ctagatgaga tgccattcac ttttactgag ctacagaaaa gcatagaaac      540

cagtgtctat aaattctttg acttattaaa agaaatcgat accagtacca aggttgataa      600

tgctatgtca agactattga agaagtataa tgtgttatgt gcactctaca gcaaattaga      660

acggacgtgt gaacttatat atttgacaca acccagcagt gcgttatcta ctgaaataaa      720

ttctatgttg gtgctaaaaa tttcttggat cactttttta ctagctaaag gagaagtatt      780

acagatggaa gatgacctgg taatctcatt tcagctaatg ttgtgtgtag ttgactattt      840

tattaagttc tcacctcctg cactactcag agagccatac aaaacagctg caatccccat      900

taatggttca cctcgaacac ccagaagagg tcagaacagg agcgctcgga tagcaaaaca      960

actagaaaat gatacgagga ttatcgaggt tctctgtaaa gaacacgagt gtaatataga     1020

tgaggtgaaa aatgtttatt tcaaaaattt tatccctttt ataaattcac ttggaattgt     1080

atcatctaat ggacttccag aggttgaaag tctttctaaa cgctatgaag aagtttatct     1140

taaaaacaaa gatttagatg caagactgtt tttggatcat gataaaacac ttcagactga     1200

tcctatagac agttttgaaa cagagagaac gccacgaaaa aacaaccctg atgaagaggc     1260

aaacgtggtt actccacaca ctccagttag gactgttatg aatactattc aacaattaat     1320

ggtgatttta aattctgcaa gtgatcagcc atcagaaaat ctgatttcct acttcaataa     1380

ttgcacagtg aatccaaaag aaaatatcct aaagagagta aaggatgttg ggcacatctt     1440

taaagagaag tttgctaacg ctgtgggcca gggctgtgtt gacatcggag tacagcgata     1500

taaacttgga gtccgattgt attaccgtgt gatggaatcc atgcttaaat cagaagaaga     1560

acgtttgtcc attcagaatt ttagcaaact cctaaatgac aacatctttc atatgtcttt     1620

actggcctgt gctcttgaag ttgtaatggc tacgtatagc agaagtacat tgcagcatct     1680

tgattctgga acagatttgt ccttcccgtg gattctgaac gtacttaatt taaaagcctt     1740

tgatttttac aaagtgattg aaagttttat caaagtggaa gccaacttga caagagaaat     1800

gataaaacat ttagaaagat gtgagcatcg aatcatggaa tcccttgcat ggctttcaga     1860

ttcaccttta tttgatctca ttaagcagtc caaggatgga gaaggacctg ataaccttga     1920

acctgcttgt cctctcagcc tgcctctcca gggtaaccat actgcagcag atatgtatct     1980

ttctcctcta agatctccaa agaaaagaac ttccactaca cgtgtaaatt ctgctgcaaa     2040

tacagagaca caagcagcct cagccttcca tactcagaag ccattgaaat ctacctccct     2100

tgccctgttt tacaaaaaag tgtaccgtct agcatatctc cgactaaata cactctgtgc     2160

acgccttctg tctgaccacc cagagctaga gcacatcatc tggactctgt ttcagcatac     2220

attgcaaaat gagtatgagc tcatgagaga ccgacatttg gaccagatta tgatgtgctc     2280

tatgtatggc atctgcaagg tgaagaacat cgacctcaag ttcaaaatca tcgtcactgc     2340

ctacaaggat cttcctcacg ctgcccagga gacctttaaa cgtgttttga tcagagaaga     2400

ggagtttgat tccattatag tattctataa ctccgttttc atgcagagac taaaaacaaa     2460

tattttacag tatgcctcca ccaggcctcc taccttgtca ccaatacctc acattcctcg     2520

aagcccttac aagttttcta gttcaccctt acggattcct ggaggtaaca tctatatatc     2580

acccctaaag agtccttata aaatttcaga aggtctgcca acacccacaa aaatgactcc     2640

gagatcaaga atcttggtct caattggtga atcatttggg acatctgaaa agttccagaa     2700

aataaaccag atggtgtgta atagtgacag agtgctcaaa agaagtgctg aaggcggcaa     2760

cccccccaaa ccactgaaaa agctgcgctt tgacatcgag ggagccgatg aagcagatgg     2820

gagtaaacat ctcccagcgg agtccaaatt ccaacagaaa ctggcagaaa tgacttccac     2880

tcgaacacga atgcaaaagc agagaatgaa tgagagcaag gatgtctcaa acaaggagga     2940

aaagtgagga cctcagggcc ctggaccctc agccctgggg acaccagact cctggctcat     3000

ggttgtgact agttcccagg ttctgctcat gttagagata taaaatgtgc aggtacaagc     3060

tgaatatttg tgtgggtgat tcgtaagcca cttcaatgtt gtaatcaatg gtagagaatt     3120

gatagcacac aggattgaga atcttgtgca gatcatgcca tttaaaatat gaaagcaagt     3180

tgtttgcatt tccaacatga gcctgctgcc ctcagaagtg agggcctctg caggggtcct     3240

gaccccctac atctggctga ctactttgcc tttcctcatg gcacatgtgt gatgtttgct     3300

cttggtttta ttaatttata tgtatttttt aatttaacgt gaataccctt agaaaatgtg     3360

tcttgtcttc caaatgcaag ttgattgact gtccacattc aaccaaatta tcttgaatct     3420

tctactgaaa cagattgtta caaactggga aaaagtacta atttctacac attggactat     3480

tttaatatta gaatctaatg tgccgtgtgt ttgtttcaca tattttactt ttgaaataca     3540

agcaaaaaaa gtataatcat atgatactgt cttactactg acacagattt catacctcag     3600

accctctaag aaccgattct tttattcacc caacacatgc tttgaactga agactattga     3660

taatactccg aggttgtttt tttctttcaa tcattcagat cactgaattt ataagtaccc     3720

atgtagtact tgaaagtcaa gtttggccac aactgtgctt aagaggaccc tagtacagta     3780

caacccaagt gcacttttta atgtttctgg gtcctgaaga atcaagatac aaattaattg     3840

tgatttacaa gcagactgtt aactatagaa gccttcagtt tttttccctc atagacgtgt     3900

ctaattacat ctcaacagtt tactctgttc ttctacatct ggggatgttt gtgttctctc     3960

tggaatggta catcttccag ggtcttttga acttgcagtt atctattttt taagccaatc     4020

tggtctaata actctggctt cttcaaagcc acaccatttc tagtccagct gtgcagaaac     4080

ttcagatgaa aacagctgca ttgaaaatag aggcactccc ttcacccccc acctaaaggt     4140

gtatttaaat tatcttgtgg gattaactta tttagagatg gtataattta aaatagggga     4200

tatttaaggt agcatcagct agcatttaag aaaatcactt tttctaaact ccatactttt     4260

tgaaaagaaa tctggtcttg ttaggaaaca aatttctatt ttgtcctcaa tttagtttca     4320

gttttactag tttgatagtt atctcaataa caaaagcaat agacagcttc ccccatttct     4380

tcattaagtt ttgcatgatc atcacacaga ttagttaggt tttaggtcaa gggcttacca     4440

tacttctagg tcttttgcta gtgagttcaa gttagaatta gtgacagaat cataggaatt     4500

ttcagagatc ctgcttcgag atttcttaaa gctgcagaca ctgcactatt ggttttgttt     4560

ttttgtaccg gttgaaacta tacattcaaa ttgctatgtt cctattttct ataatagttt     4620

gtctatttta aaataaacta gttgttcaga gccttaaaaa aaaaaaaaaa aaa            4673


<210>  36
<211>  956
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Thr Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955     


<210>  37
<211>  8730
<212>  DNA
<213>  Homo sapiens

<400>  37
gtgcggttcg gaggcggggc aggtgggggc gggcccaggt agcaggtttg gctgcgcggg       60

ggccgcgcgt cggagtttcc ccctttctag ggtgaggatg gttctacaca gccacccgga      120

gttccttagt tgaaaggtgc gccctgctgt gacagaatgt ggtaattgta atctttaaca      180

ttttcatgta aaacatattt cctgatcatc tttccattgt cttcatggaa aattgataaa      240

tatttgtgcc ttccaactct cgtcttggtt gaatgacttc atcttaatac aacatggaca      300

ccacgttgct gaaaacatgc tttgggactg ccactgaatt tatcttttgc ggttttatga      360

caaagttatt agtagtttcc cttttttgaa ttagtatttt gaagttaata tcacaatgag      420

ttcaggctta tggagccaag aaaaagtcac ttcaccctac tgggaagagc ggatttttta      480

cttgcttctt caagaatgca gcgttacaga caaacaaaca caaaagctcc ttaaagtacc      540

gaagggaagt ataggacagt atattcaaga tcgttctgtg gggcattcaa ggattccttc      600

tgcaaaaggc aagaaaaatc agattggatt aaaaattcta gagcaacctc atgcagttct      660

ctttgttgat gaaaaggatg ttgtagagat aaatgaaaag ttcacagagt tacttttggc      720

aattaccaat tgtgaggaga ggttcagcct gtttaaaaac agaaacagac taagtaaagg      780

cctccaaata gacgtgggct gtcctgtgaa agtacagctg agatctgggg aagaaaaatt      840

tcctggagtt gtacgcttca gaggacccct gttagcagag aggacagtct ccggaatatt      900

ctttggagtt gaattgctgg aagaaggtcg tggtcaaggt ttcactgacg gggtgtacca      960

agggaaacag ctttttcagt gtgatgaaga ttgtggcgtg tttgttgcat tggacaagct     1020

agaactcata gaagatgatg acactgcatt ggaaagtgat tacgcaggtc ctggggacac     1080

aatgcaggtc gaacttcctc ctttggaaat aaactccaga gtttctttga aggttggaga     1140

aacaatagaa tctggaacag ttatattctg tgatgttttg ccaggaaaag aaagcttagg     1200

atattttgtt ggtgtggaca tggataaccc tattggcaac tgggatggaa gatttgatgg     1260

agtgcagctt tgtagttttg cgtgtgttga aagtacaatt ctattgcaca tcaatgatat     1320

catcccagct ttatcagaga gtgtgacgca ggaaaggagg cctcccaaac ttgcctttat     1380

gtcaagaggt gttggggaca aaggttcatc cagtcataat aaaccaaagg ctacaggatc     1440

tacctcagac cctggaaata gaaacagatc tgaattattt tataccttaa atgggtcttc     1500

tgttgactca caaccacaat ccaaatcaaa aaatacatgg tacattgatg aagttgcaga     1560

agaccctgca aaatctctta cagagatatc tacagacttt gaccgttctt caccaccact     1620

ccagcctcct cctgtgaact cactgaccac cgagaacaga ttccactctt taccattcag     1680

tctcaccaag atgcccaata ccaatggaag tattggccac agtccacttt ctctgtcagc     1740

ccagtctgta atggaagagc taaacactgc acccgtccaa gagagtccac ccttggccat     1800

gcctcctggg aactcacatg gtctagaagt gggctcattg gctgaagtta aggagaaccc     1860

tcctttctat ggggtaatcc gttggatcgg tcagccacca ggactgaatg aagtgctcgc     1920

tggactggaa ctggaagatg agtgtgcagg ctgtacggat ggaaccttca gaggcactcg     1980

gtatttcacc tgtgccctga agaaggcgct gtttgtgaaa ctgaagagct gcaggcctga     2040

ctctaggttt gcatcattgc agccggtttc caatcagatt gagcgctgta actctttagc     2100

atttggaggc tacttaagtg aagtagtaga agaaaatact ccaccaaaaa tggaaaaaga     2160

aggcttggag ataatgattg ggaagaagaa aggcatccag ggtcattaca attcttgtta     2220

cttagactca accttattct gcttatttgc ttttagttct gttctggaca ctgtgttact     2280

tagacccaaa gaaaagaacg atgtagaata ttatagtgaa acccaagagc tactgaggac     2340

agaaattgtt aatcctctga gaatatatgg atatgtgtgt gccacaaaaa ttatgaaact     2400

gaggaaaata cttgaaaagg tggaggctgc atcaggattt acctctgaag aaaaagatcc     2460

tgaggaattc ttgaatattc tgtttcatca tattttaagg gtagaacctt tgctaaaaat     2520

aagatcagca ggtcaaaagg tacaagattg ttacttctat caaattttta tggaaaaaaa     2580

tgagaaagtt ggcgttccca caattcagca gttgttagaa tggtctttta tcaacagtaa     2640

cctgaaattt gcagaggcac catcatgtct gattattcag atgcctcgat ttggaaaaga     2700

ctttaaacta tttaaaaaaa tttttccttc tctggaatta aatataacag atttacttga     2760

agacactccc agacagtgcc ggatatgtgg agggcttgca atgtatgagt gtagagaatg     2820

ctacgacgat ccggacatct cagctggaaa aatcaagcag ttttgtaaaa cctgcaacac     2880

tcaagtccac cttcatccga agaggctgaa tcataaatat aacccagtgt cacttcccaa     2940

agacttaccc gactgggact ggagacacgg ctgcatccct tgccagaata tggagttatt     3000

tgctgttctc tgcatagaaa caagccacta tgttgctttt gtgaagtatg ggaaggacga     3060

ttctgcctgg ctcttctttg acagcatggc cgatcgggat ggtggtcaga atggcttcaa     3120

cattcctcaa gtcaccccat gcccagaagt aggagagtac ttgaagatgt ctctggaaga     3180

cctgcattcc ttggactcca ggagaatcca aggctgtgca cgaagactgc tttgtgatgc     3240

atatatgtgc atgtaccaga gtccaacaat gagtttgtac aaataactgg ggtcatcggg     3300

aaaggcaaag aaactgaagg cagagtccta acgttgcatc ttattcgagc tggcagttct     3360

gttcacgtcc attgccggca atggatgtct ttgtggtgat gatccttcag aaaaggatgc     3420

ctctgtttaa aaacaaattg cttttgtgtc cctgaagtat ttaataagaa gcattttgca     3480

ctctagaaag tatgtttgtg ttggtttttt aagaagtcta aatgaagtta ttaatacctg     3540

aagctttaag ttaagtgcat tgatcatatg atatttttgg aagcatacaa ttttaattgt     3600

ggaagtttaa agcctctttt agtccattga gaatgtaaat aaatgtgtct tctttatgga     3660

ccaaggatat gaaatcattt ttcttttgta gctaacggtt gccttgagga agaaataatt     3720

tggttttatt aagagtctac tctcaatcca gttattagag atgtactgag tttgatttgt     3780

taatcctttc tatatactgc tgatcttgca tgtctacaat ctgctcagtt tttctgtgtt     3840

tctgcaatag tggtcagaaa aatacttaaa ttcccttaat ggtgttgttt tctatttgtt     3900

ctggttttga gataaatgag tgattctgtc cccaaatgtc catttttgaa gtgattttcc     3960

tggaggatta gggtatttag cagttgaagc tcttcattca tagtagttac tgtcagctaa     4020

caggtttttt aaggctttta actattaata ttttatggaa tggggcaaag taaattgatg     4080

aaagaattgg agtgataata gtcctttaca aacatacagt ccataagaaa atgaatttgg     4140

catatagaat tattacaatt tcctgggaga gatggatatt taaacctcta ttattttaga     4200

caagactgtc tagaacttaa gtttgatctg tcagccagta ctcccattaa attcagtgta     4260

gtttcacttg atagaatcag atatgttatc gaaatgttag cagcagcttc atcctccttc     4320

tgattaaagt aagtagaaat gggatgtttt gtttaataac agccatagtg tgtgtttaga     4380

ccacagcgga tgttgtagac caggaccata gatgatacat gtcagtgctg tggaatgtgc     4440

attctctgag tgttgttttg tggtatcatt gtctttcctg aatgactttc taactgtgca     4500

gaaaggcaga aaagtcatca tatgtatatg tcatatgact ttataaaata tttaatgtga     4560

caaaaagtgg aaagaatctt tacaaaccct gcaattactt ttttaaaggc acttttactc     4620

tttggtttta tcattccatt ttgctaatat ttactagctt tataaattac agtaaggtac     4680

aaaaactcat cttgtaatat tttcattttt gaagtgaaaa agtacatata ttttgcacaa     4740

ggttttatac tgctaagtgc ttggttgggg tggtgagatg atgattagat caggggtgag     4800

gctgagagac tctgggttta gggctagccc tgcctccatc tcccttgggt aaaatgaagg     4860

gtgtggggta aaagatgcat aaggcctttt ctagctctga cagcctagaa gtccaatcac     4920

cctgtaataa atatgtgttg aatgaagaaa tgggtgaatg agcttgtcaa tgtgatttta     4980

aaaaattgac tacctggagg aatgattagg aatctaaatg aagccagccc tcggtatctg     5040

caggtttctc atccatggat tcaaccaact gcaaatggaa aatacgattt tttttaaaaa     5100

aaggatggtt acatccgtat tgaacatgta cagacttttt tcttgtcatt attctctgaa     5160

caatacaaga actctttatg tagcatttac atttattagg tattataagt aatctagaga     5220

ttatttaatt aaaatataca ggaggatgtg tgtcagttat atgcaaattc tgtaccattt     5280

tgtatcaggg aattgagcat cttcagatgt tggtatctgc agggatcctg gaaccaaacc     5340

cctgcagata ctaagggctg acgatctagg taagactgga tttaacagtt ggaaaaaaaa     5400

aaaaaaaagg agagagaaga cagttccttt cctgtagaaa ttaaaacaaa atacaaattg     5460

aggaagctct gctacccagg ctgtcatggt agagaacttg aagaagacct gtttggatgg     5520

acacctggtt tcaaaagtca ggtgtggaga ctgttaaatg ggagggcctc atccataaat     5580

gatttctggc aacgtcttct tcaggtggag cttgacgtct ttttaatgtt acttggggag     5640

ggagtgctca ttaagggatg ccagggccag ctctggtggt tcctggggag gctgcgtcct     5700

tccctgcttc tgcatgtcat gaggcagcag gaaggtttcc cctgcacctg tctgtcctgg     5760

ctccctctgg gtagccccct actgttctgt gcttcagcac agcctggttt gtcaagaggc     5820

acatagttgg ggctgggctg catggcacag gggcttatgt gcctgctggt tatttaattt     5880

tcagccttaa gttttcttta atattttcct gttggctatt taaaggtttt ggttatcttt     5940

tattccttat ctacaatcaa gatgacaatg taattgaatt atcttattta taacacggtt     6000

cgtgattcat gattcatgat tacaagtaga aaatatgtca tgttcctcac ctccaaataa     6060

atatgtgtgt gtctgtgtgt gtgtatatat gtatgtggcg gagagggaga gagtggggaa     6120

ggagagcagt gttatcatac atagagaggc taaatgtgtc ccatccctca ctgtcagctt     6180

tataaaggag tttgactcca tccacagaag aatgttttat aagactagga aaacacgttg     6240

aaaactagga taaacagcaa caaaaatcaa ctaaatatgt tgttactgtt gctaaggatt     6300

ttctccttag aataatttag gatttttaaa aatttctgtt tgccaaatgc tgtagataaa     6360

tggccagatt cttcctatcc ctaggattcc tttattattt tttttcacag attttgagaa     6420

caagggggag agatagtatg gaagattaag attccattaa tcttatagaa ctgtgttgtc     6480

acccaaattc ctgcttgttt gaacatggca tcttcataga ttcaggattc actaccctct     6540

atagctggat cttgaaaatt atctggccag ataattttgc atctgcttgg atgattgtag     6600

actgagatgt gagtggagga taaagtatta gacttttgct gagtaactgc caaccaagaa     6660

gtatttatcg gacacttact aggtgcctag gattgtatca gagggaatat gaaatgtgtc     6720

cctgccctac ctagttttaa cgacagaata tctattaaag gctacttagc tgaagggtaa     6780

gggtgacagg tctaggggaa gctttgggag gtggtgtgct gtgacagaaa aagtggcaga     6840

gtagggacga gagacctgca ttctagccct gtttctgtca cttgctctgt acacttagac     6900

aacagcttga cctcttgagc tttagtttcc tcctctgcat aatgagaggg ttagactact     6960

gaattgtatg ggaaaaaaat acaaattcct gggtcctagg ccatgcctgc tgaatccgac     7020

tgttcaggaa gaggcctagg aaatctgtga gggaatcccc aggggaatct cgtgaccagc     7080

caggtgtgaa atctgctaac tggaagatct caaagcttcc ttcacttttt gtgattttgt     7140

ggtcatgtaa cgttactgta ttattctacg taaatgtggg tacttggatg tttatcatac     7200

tgtttctctg tgtttacata ctaatttgtg taagaaatgc attttagtct gtgtacctca     7260

acctgctgtt tgtttcctag aggtgttagt agtctttaaa tacaagtaag acttaagagg     7320

atatttgatg ttatttacct ggatattttc ttcccctttt atttatttag aggaaattga     7380

gattctagga gccaaaaaaa tgaaaacaaa attctaaggc aaagttaaag aaaaaaatta     7440

cattatttct taccatttgc tactttataa tgaaaattta aaaattatat gggaagattt     7500

ttctctggga taacaaatcc ttgtcataaa gtaagaggtc tttttaaagt aggtaggcta     7560

taaggcctgt aatttaaaat aatactcctt tctctagggt ttggtgcaat tctccattaa     7620

tgaagataac atttgaattc cccaaagcag gtgaggagtc ggggaggaga aagcgatgtt     7680

aaaatgaaaa ctcactgcaa aagaggaggc agaggaagaa ggaatgtaaa ccccttaaag     7740

cagatgtgtg tggggcctta tgaagaccag gattctgcgg gtgtcagggg attgcccctc     7800

ttgacagaga ctagggtttt agactgaggc ttcctgcagg gtgttcgcat tgcccttctc     7860

cgttcccctt cagacctttc tggggagaag aggtgggagg aggggagaaa gactgttcat     7920

cttattctga atcctggagc agctgaaggt tttctcttga gtcaggatgc agtggtaatg     7980

cattaaccag caagtgtggc caaggataat gaaaaagtgg gaaaggaagg tcctcctcct     8040

ccctgattgt agcatccagc agtctctgta gccaggttac tcaagaacca catttgattt     8100

cctggccctt tgccttggca gtgatggcat ttttatttca ctgtgtttta aagtcttcat     8160

ttatttttat aacatgggtt agggagaagg gccacaaatg gagggattgt cctttcaagc     8220

accacagctt cagataaaat tagtactttc aaatattgtc cactttaact taaaaaattc     8280

tagagggatt atattggaga ctcaactgcc cttggtttta gtttataaaa tggcctagta     8340

ctgtggaatt ttaattttag aaagtcttag catcagatca taaacattca ttaaaagaac     8400

tcacatccca tctgaaactt cccaggggag ttgggattct tagtagattg gtagaaaggg     8460

gctcattttc tactgcattt cccatttttg gtatcttgtt cagcatgttt tatttttatt     8520

tcttgtctgc agaacatcct atatttatga gaacattctt taagaagacc accacataga     8580

ataccccttc ctatcagctc gctctgattt agccttaatt ttgttaaatt ttttagagat     8640

gaatgaagtg ctgctgtgga aagaaatgta catatactat ttctgtatca ttaaaattac     8700

atttttatgg ttcaaaaaaa aaaaaaaaaa                                      8730


<210>  38
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Thr 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp 
            500                 505                 510         


Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr 
                805                 810                 815     


Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950             


<210>  39
<211>  8531
<212>  DNA
<213>  Homo sapiens

<400>  39
aggtagcagg tttggctgcg cgggggccgc gcgtcggagt ttcccccttt ctagggtgag       60

gatggttcta cacagccacc cggagttcct tagttgaaag gtgcgccctg ctgtgacagc      120

atggacacca cgttgctgaa aacatgcttt gggactgcca ctgaatttat cttttgcggt      180

tttatgacaa agttattagt agtttccctt ttttgaatta gtattttgaa gttaatatca      240

caatgagttc aggcttatgg agccaagaaa aagtcacttc accctactgg gaagagcgga      300

ttttttactt gcttcttcaa gaatgcagcg ttacagacaa acaaacacaa aagctcctta      360

aagtaccgaa gggaagtata ggacagtata ttcaagatcg ttctgtgggg cattcaagga      420

ttccttctgc aaaaggcaag aaaaatcaga ttggattaaa aattctagag caacctcatg      480

cagttctctt tgttgatgaa aaggatgttg tagagataaa tgaaaagttc acagagttac      540

ttttggcaat taccaattgt gaggagaggt tcagcctgtt taaaaacaga aacagactaa      600

gtaaaggcct ccaaatagac gtgggctgtc ctgtgaaagt acagctgaga tctggggaag      660

aaaaatttcc tggagttgta cgcttcagag gacccctgtt agcagagagg acagtctccg      720

gaatattctt tggagttgaa ttgctggaag aaggtcgtgg tcaaggtttc actgacgggg      780

tgtaccaagg gaaacagctt tttcagtgtg atgaagattg tggcgtgttt gttgcattgg      840

acaagctaga actcatagaa gatgatgaca ctgcattgga aagtgattac gcaggtcctg      900

gggacacaat gcaggtcgaa cttcctcctt tggaaataaa ctccagagtt tctttgaagg      960

ttggagaaac aatagaatct ggaacagtta tattctgtga tgttttgcca ggaaaagaaa     1020

gcttaggata ttttgttggt gtggacatgg ataaccctat tggcaactgg gatggaagat     1080

ttgatggagt gcagctttgt agttttgcgt gtgttgaaag tacaattcta ttgcacatca     1140

atgatatcat cccagagagt gtgacgcagg aaaggaggcc tcccaaactt gcctttatgt     1200

caagaggtgt tggggacaaa ggttcatcca gtcataataa accaaaggct acaggatcta     1260

cctcagaccc tggaaataga aacagatctg aattatttta taccttaaat gggtcttctg     1320

ttgactcaca accacaatcc aaatcaaaaa atacatggta cattgatgaa gttgcagaag     1380

accctgcaaa atctcttaca gagatatcta cagactttga ccgttcttca ccaccactcc     1440

agcctcctcc tgtgaactca ctgaccaccg agaacagatt ccactcttta ccattcagtc     1500

tcaccaagat gcccaatacc aatggaagta ttggccacag tccactttct ctgtcagccc     1560

agtctgtaat ggaagagcta aacactgcac ccgtccaaga gagtccaccc ttggccatgc     1620

ctcctgggaa ctcacatggt ctagaagtgg gctcattggc tgaagttaag gagaaccctc     1680

ctttctatgg ggtaatccgt tggatcggtc agccaccagg actgaatgaa gtgctcgctg     1740

gactggaact ggaagatgag tgtgcaggct gtacggatgg aaccttcaga ggcactcggt     1800

atttcacctg tgccctgaag aaggcgctgt ttgtgaaact gaagagctgc aggcctgact     1860

ctaggtttgc atcattgcag ccggtttcca atcagattga gcgctgtaac tctttagcat     1920

ttggaggcta cttaagtgaa gtagtagaag aaaatactcc accaaaaatg gaaaaagaag     1980

gcttggagat aatgattggg aagaagaaag gcatccaggg tcattacaat tcttgttact     2040

tagactcaac cttattctgc ttatttgctt ttagttctgt tctggacact gtgttactta     2100

gacccaaaga aaagaacgat gtagaatatt atagtgaaac ccaagagcta ctgaggacag     2160

aaattgttaa tcctctgaga atatatggat atgtgtgtgc cacaaaaatt atgaaactga     2220

ggaaaatact tgaaaaggtg gaggctgcat caggatttac ctctgaagaa aaagatcctg     2280

aggaattctt gaatattctg tttcatcata ttttaagggt agaacctttg ctaaaaataa     2340

gatcagcagg tcaaaaggta caagattgtt acttctatca aatttttatg gaaaaaaatg     2400

agaaagttgg cgttcccaca attcagcagt tgttagaatg gtcttttatc aacagtaacc     2460

tgaaatttgc agaggcacca tcatgtctga ttattcagat gcctcgattt ggaaaagact     2520

ttaaactatt taaaaaaatt tttccttctc tggaattaaa tataacagat ttacttgaag     2580

acactcccag acagtgccgg atatgtggag ggcttgcaat gtatgagtgt agagaatgct     2640

acgacgatcc ggacatctca gctggaaaaa tcaagcagtt ttgtaaaacc tgcaacactc     2700

aagtccacct tcatccgaag aggctgaatc ataaatataa cccagtgtca cttcccaaag     2760

acttacccga ctgggactgg agacacggct gcatcccttg ccagaatatg gagttatttg     2820

ctgttctctg catagaaaca agccactatg ttgcttttgt gaagtatggg aaggacgatt     2880

ctgcctggct cttctttgac agcatggccg atcgggatgg tggtcagaat ggcttcaaca     2940

ttcctcaagt caccccatgc ccagaagtag gagagtactt gaagatgtct ctggaagacc     3000

tgcattcctt ggactccagg agaatccaag gctgtgcacg aagactgctt tgtgatgcat     3060

atatgtgcat gtaccagagt ccaacaatga gtttgtacaa ataactgggg tcatcgggaa     3120

aggcaaagaa actgaaggca gagtcctaac gttgcatctt attcgagctg gcagttctgt     3180

tcacgtccat tgccggcaat ggatgtcttt gtggtgatga tccttcagaa aaggatgcct     3240

ctgtttaaaa acaaattgct tttgtgtccc tgaagtattt aataagaagc attttgcact     3300

ctagaaagta tgtttgtgtt ggttttttaa gaagtctaaa tgaagttatt aatacctgaa     3360

gctttaagtt aagtgcattg atcatatgat atttttggaa gcatacaatt ttaattgtgg     3420

aagtttaaag cctcttttag tccattgaga atgtaaataa atgtgtcttc tttatggacc     3480

aaggatatga aatcattttt cttttgtagc taacggttgc cttgaggaag aaataatttg     3540

gttttattaa gagtctactc tcaatccagt tattagagat gtactgagtt tgatttgtta     3600

atcctttcta tatactgctg atcttgcatg tctacaatct gctcagtttt tctgtgtttc     3660

tgcaatagtg gtcagaaaaa tacttaaatt cccttaatgg tgttgttttc tatttgttct     3720

ggttttgaga taaatgagtg attctgtccc caaatgtcca tttttgaagt gattttcctg     3780

gaggattagg gtatttagca gttgaagctc ttcattcata gtagttactg tcagctaaca     3840

ggttttttaa ggcttttaac tattaatatt ttatggaatg gggcaaagta aattgatgaa     3900

agaattggag tgataatagt cctttacaaa catacagtcc ataagaaaat gaatttggca     3960

tatagaatta ttacaatttc ctgggagaga tggatattta aacctctatt attttagaca     4020

agactgtcta gaacttaagt ttgatctgtc agccagtact cccattaaat tcagtgtagt     4080

ttcacttgat agaatcagat atgttatcga aatgttagca gcagcttcat cctccttctg     4140

attaaagtaa gtagaaatgg gatgttttgt ttaataacag ccatagtgtg tgtttagacc     4200

acagcggatg ttgtagacca ggaccataga tgatacatgt cagtgctgtg gaatgtgcat     4260

tctctgagtg ttgttttgtg gtatcattgt ctttcctgaa tgactttcta actgtgcaga     4320

aaggcagaaa agtcatcata tgtatatgtc atatgacttt ataaaatatt taatgtgaca     4380

aaaagtggaa agaatcttta caaaccctgc aattactttt ttaaaggcac ttttactctt     4440

tggttttatc attccatttt gctaatattt actagcttta taaattacag taaggtacaa     4500

aaactcatct tgtaatattt tcatttttga agtgaaaaag tacatatatt ttgcacaagg     4560

ttttatactg ctaagtgctt ggttggggtg gtgagatgat gattagatca ggggtgaggc     4620

tgagagactc tgggtttagg gctagccctg cctccatctc ccttgggtaa aatgaagggt     4680

gtggggtaaa agatgcataa ggccttttct agctctgaca gcctagaagt ccaatcaccc     4740

tgtaataaat atgtgttgaa tgaagaaatg ggtgaatgag cttgtcaatg tgattttaaa     4800

aaattgacta cctggaggaa tgattaggaa tctaaatgaa gccagccctc ggtatctgca     4860

ggtttctcat ccatggattc aaccaactgc aaatggaaaa tacgattttt tttaaaaaaa     4920

ggatggttac atccgtattg aacatgtaca gacttttttc ttgtcattat tctctgaaca     4980

atacaagaac tctttatgta gcatttacat ttattaggta ttataagtaa tctagagatt     5040

atttaattaa aatatacagg aggatgtgtg tcagttatat gcaaattctg taccattttg     5100

tatcagggaa ttgagcatct tcagatgttg gtatctgcag ggatcctgga accaaacccc     5160

tgcagatact aagggctgac gatctaggta agactggatt taacagttgg aaaaaaaaaa     5220

aaaaaaggag agagaagaca gttcctttcc tgtagaaatt aaaacaaaat acaaattgag     5280

gaagctctgc tacccaggct gtcatggtag agaacttgaa gaagacctgt ttggatggac     5340

acctggtttc aaaagtcagg tgtggagact gttaaatggg agggcctcat ccataaatga     5400

tttctggcaa cgtcttcttc aggtggagct tgacgtcttt ttaatgttac ttggggaggg     5460

agtgctcatt aagggatgcc agggccagct ctggtggttc ctggggaggc tgcgtccttc     5520

cctgcttctg catgtcatga ggcagcagga aggtttcccc tgcacctgtc tgtcctggct     5580

ccctctgggt agccccctac tgttctgtgc ttcagcacag cctggtttgt caagaggcac     5640

atagttgggg ctgggctgca tggcacaggg gcttatgtgc ctgctggtta tttaattttc     5700

agccttaagt tttctttaat attttcctgt tggctattta aaggttttgg ttatctttta     5760

ttccttatct acaatcaaga tgacaatgta attgaattat cttatttata acacggttcg     5820

tgattcatga ttcatgatta caagtagaaa atatgtcatg ttcctcacct ccaaataaat     5880

atgtgtgtgt ctgtgtgtgt gtatatatgt atgtggcgga gagggagaga gtggggaagg     5940

agagcagtgt tatcatacat agagaggcta aatgtgtccc atccctcact gtcagcttta     6000

taaaggagtt tgactccatc cacagaagaa tgttttataa gactaggaaa acacgttgaa     6060

aactaggata aacagcaaca aaaatcaact aaatatgttg ttactgttgc taaggatttt     6120

ctccttagaa taatttagga tttttaaaaa tttctgtttg ccaaatgctg tagataaatg     6180

gccagattct tcctatccct aggattcctt tattattttt tttcacagat tttgagaaca     6240

agggggagag atagtatgga agattaagat tccattaatc ttatagaact gtgttgtcac     6300

ccaaattcct gcttgtttga acatggcatc ttcatagatt caggattcac taccctctat     6360

agctggatct tgaaaattat ctggccagat aattttgcat ctgcttggat gattgtagac     6420

tgagatgtga gtggaggata aagtattaga cttttgctga gtaactgcca accaagaagt     6480

atttatcgga cacttactag gtgcctagga ttgtatcaga gggaatatga aatgtgtccc     6540

tgccctacct agttttaacg acagaatatc tattaaaggc tacttagctg aagggtaagg     6600

gtgacaggtc taggggaagc tttgggaggt ggtgtgctgt gacagaaaaa gtggcagagt     6660

agggacgaga gacctgcatt ctagccctgt ttctgtcact tgctctgtac acttagacaa     6720

cagcttgacc tcttgagctt tagtttcctc ctctgcataa tgagagggtt agactactga     6780

attgtatggg aaaaaaatac aaattcctgg gtcctaggcc atgcctgctg aatccgactg     6840

ttcaggaaga ggcctaggaa atctgtgagg gaatccccag gggaatctcg tgaccagcca     6900

ggtgtgaaat ctgctaactg gaagatctca aagcttcctt cactttttgt gattttgtgg     6960

tcatgtaacg ttactgtatt attctacgta aatgtgggta cttggatgtt tatcatactg     7020

tttctctgtg tttacatact aatttgtgta agaaatgcat tttagtctgt gtacctcaac     7080

ctgctgtttg tttcctagag gtgttagtag tctttaaata caagtaagac ttaagaggat     7140

atttgatgtt atttacctgg atattttctt ccccttttat ttatttagag gaaattgaga     7200

ttctaggagc caaaaaaatg aaaacaaaat tctaaggcaa agttaaagaa aaaaattaca     7260

ttatttctta ccatttgcta ctttataatg aaaatttaaa aattatatgg gaagattttt     7320

ctctgggata acaaatcctt gtcataaagt aagaggtctt tttaaagtag gtaggctata     7380

aggcctgtaa tttaaaataa tactcctttc tctagggttt ggtgcaattc tccattaatg     7440

aagataacat ttgaattccc caaagcaggt gaggagtcgg ggaggagaaa gcgatgttaa     7500

aatgaaaact cactgcaaaa gaggaggcag aggaagaagg aatgtaaacc ccttaaagca     7560

gatgtgtgtg gggccttatg aagaccagga ttctgcgggt gtcaggggat tgcccctctt     7620

gacagagact agggttttag actgaggctt cctgcagggt gttcgcattg cccttctccg     7680

ttccccttca gacctttctg gggagaagag gtgggaggag gggagaaaga ctgttcatct     7740

tattctgaat cctggagcag ctgaaggttt tctcttgagt caggatgcag tggtaatgca     7800

ttaaccagca agtgtggcca aggataatga aaaagtggga aaggaaggtc ctcctcctcc     7860

ctgattgtag catccagcag tctctgtagc caggttactc aagaaccaca tttgatttcc     7920

tggccctttg ccttggcagt gatggcattt ttatttcact gtgttttaaa gtcttcattt     7980

atttttataa catgggttag ggagaagggc cacaaatgga gggattgtcc tttcaagcac     8040

cacagcttca gataaaatta gtactttcaa atattgtcca ctttaactta aaaaattcta     8100

gagggattat attggagact caactgccct tggttttagt ttataaaatg gcctagtact     8160

gtggaatttt aattttagaa agtcttagca tcagatcata aacattcatt aaaagaactc     8220

acatcccatc tgaaacttcc caggggagtt gggattctta gtagattggt agaaaggggc     8280

tcattttcta ctgcatttcc catttttggt atcttgttca gcatgtttta tttttatttc     8340

ttgtctgcag aacatcctat atttatgaga acattcttta agaagaccac cacatagaat     8400

accccttcct atcagctcgc tctgatttag ccttaatttt gttaaatttt ttagagatga     8460

atgaagtgct gctgtggaaa gaaatgtaca tatactattt ctgtatcatt aaaattacat     8520

ttttatggtt c                                                          8531


<210>  40
<211>  8623
<212>  DNA
<213>  Homo sapiens

<400>  40
aggtagcagg tttggctgcg cgggggccgc gcgtcggagg taaatactag ggcggtgggt       60

gtggggagcc ggggccggcc cgggacgcgg gctggggagc cggggcgagg ggcgacgccc      120

cgccgcccga gtttccccct ttctagggtg aggatggttc tacacagcca cccggagttc      180

cttagttgaa aggtgcgccc tgctgtgaca gcatggacac cacgttgctg aaaacatgct      240

ttgggactgc cactgaattt atcttttgcg gttttatgac aaagttatta gtagtttccc      300

ttttttgaat tagtattttg aagttaatat cacaatgagt tcaggcttat ggagccaaga      360

aaaagtcact tcaccctact gggaagagcg gattttttac ttgcttcttc aagaatgcag      420

cgttacagac aaacaaacac aaaagctcct taaagtaccg aagggaagta taggacagta      480

tattcaagat cgttctgtgg ggcattcaag gattccttct gcaaaaggca agaaaaatca      540

gattggatta aaaattctag agcaacctca tgcagttctc tttgttgatg aaaaggatgt      600

tgtagagata aatgaaaagt tcacagagtt acttttggca attaccaatt gtgaggagag      660

gttcagcctg tttaaaaaca gaaacagact aagtaaaggc ctccaaatag acgtgggctg      720

tcctgtgaaa gtacagctga gatctgggga agaaaaattt cctggagttg tacgcttcag      780

aggacccctg ttagcagaga ggacagtctc cggaatattc tttggagttg aattgctgga      840

agaaggtcgt ggtcaaggtt tcactgacgg ggtgtaccaa gggaaacagc tttttcagtg      900

tgatgaagat tgtggcgtgt ttgttgcatt ggacaagcta gaactcatag aagatgatga      960

cactgcattg gaaagtgatt acgcaggtcc tggggacaca atgcaggtcg aacttcctcc     1020

tttggaaata aactccagag tttctttgaa ggttggagaa acaatagaat ctggaacagt     1080

tatattctgt gatgttttgc caggaaaaga aagcttagga tattttgttg gtgtggacat     1140

ggataaccct attggcaact gggatggaag atttgatgga gtgcagcttt gtagttttgc     1200

gtgtgttgaa agtacaattc tattgcacat caatgatatc atcccagaga gtgtgacgca     1260

ggaaaggagg cctcccaaac ttgcctttat gtcaagaggt gttggggaca aaggttcatc     1320

cagtcataat aaaccaaagg ctacaggatc tacctcagac cctggaaata gaaacagatc     1380

tgaattattt tataccttaa atgggtcttc tgttgactca caaccacaat ccaaatcaaa     1440

aaatacatgg tacattgatg aagttgcaga agaccctgca aaatctctta cagagatatc     1500

tacagacttt gaccgttctt caccaccact ccagcctcct cctgtgaact cactgaccac     1560

cgagaacaga ttccactctt taccattcag tctcaccaag atgcccaata ccaatggaag     1620

tattggccac agtccacttt ctctgtcagc ccagtctgta atggaagagc taaacactgc     1680

acccgtccaa gagagtccac ccttggccat gcctcctggg aactcacatg gtctagaagt     1740

gggctcattg gctgaagtta aggagaaccc tcctttctat ggggtaatcc gttggatcgg     1800

tcagccacca ggactgaatg aagtgctcgc tggactggaa ctggaagatg agtgtgcagg     1860

ctgtacggat ggaaccttca gaggcactcg gtatttcacc tgtgccctga agaaggcgct     1920

gtttgtgaaa ctgaagagct gcaggcctga ctctaggttt gcatcattgc agccggtttc     1980

caatcagatt gagcgctgta actctttagc atttggaggc tacttaagtg aagtagtaga     2040

agaaaatact ccaccaaaaa tggaaaaaga aggcttggag ataatgattg ggaagaagaa     2100

aggcatccag ggtcattaca attcttgtta cttagactca accttattct gcttatttgc     2160

ttttagttct gttctggaca ctgtgttact tagacccaaa gaaaagaacg atgtagaata     2220

ttatagtgaa acccaagagc tactgaggac agaaattgtt aatcctctga gaatatatgg     2280

atatgtgtgt gccacaaaaa ttatgaaact gaggaaaata cttgaaaagg tggaggctgc     2340

atcaggattt acctctgaag aaaaagatcc tgaggaattc ttgaatattc tgtttcatca     2400

tattttaagg gtagaacctt tgctaaaaat aagatcagca ggtcaaaagg tacaagattg     2460

ttacttctat caaattttta tggaaaaaaa tgagaaagtt ggcgttccca caattcagca     2520

gttgttagaa tggtctttta tcaacagtaa cctgaaattt gcagaggcac catcatgtct     2580

gattattcag atgcctcgat ttggaaaaga ctttaaacta tttaaaaaaa tttttccttc     2640

tctggaatta aatataacag atttacttga agacactccc agacagtgcc ggatatgtgg     2700

agggcttgca atgtatgagt gtagagaatg ctacgacgat ccggacatct cagctggaaa     2760

aatcaagcag ttttgtaaaa cctgcaacac tcaagtccac cttcatccga agaggctgaa     2820

tcataaatat aacccagtgt cacttcccaa agacttaccc gactgggact ggagacacgg     2880

ctgcatccct tgccagaata tggagttatt tgctgttctc tgcatagaaa caagccacta     2940

tgttgctttt gtgaagtatg ggaaggacga ttctgcctgg ctcttctttg acagcatggc     3000

cgatcgggat ggtggtcaga atggcttcaa cattcctcaa gtcaccccat gcccagaagt     3060

aggagagtac ttgaagatgt ctctggaaga cctgcattcc ttggactcca ggagaatcca     3120

aggctgtgca cgaagactgc tttgtgatgc atatatgtgc atgtaccaga gtccaacaat     3180

gagtttgtac aaataactgg ggtcatcggg aaaggcaaag aaactgaagg cagagtccta     3240

acgttgcatc ttattcgagc tggcagttct gttcacgtcc attgccggca atggatgtct     3300

ttgtggtgat gatccttcag aaaaggatgc ctctgtttaa aaacaaattg cttttgtgtc     3360

cctgaagtat ttaataagaa gcattttgca ctctagaaag tatgtttgtg ttggtttttt     3420

aagaagtcta aatgaagtta ttaatacctg aagctttaag ttaagtgcat tgatcatatg     3480

atatttttgg aagcatacaa ttttaattgt ggaagtttaa agcctctttt agtccattga     3540

gaatgtaaat aaatgtgtct tctttatgga ccaaggatat gaaatcattt ttcttttgta     3600

gctaacggtt gccttgagga agaaataatt tggttttatt aagagtctac tctcaatcca     3660

gttattagag atgtactgag tttgatttgt taatcctttc tatatactgc tgatcttgca     3720

tgtctacaat ctgctcagtt tttctgtgtt tctgcaatag tggtcagaaa aatacttaaa     3780

ttcccttaat ggtgttgttt tctatttgtt ctggttttga gataaatgag tgattctgtc     3840

cccaaatgtc catttttgaa gtgattttcc tggaggatta gggtatttag cagttgaagc     3900

tcttcattca tagtagttac tgtcagctaa caggtttttt aaggctttta actattaata     3960

ttttatggaa tggggcaaag taaattgatg aaagaattgg agtgataata gtcctttaca     4020

aacatacagt ccataagaaa atgaatttgg catatagaat tattacaatt tcctgggaga     4080

gatggatatt taaacctcta ttattttaga caagactgtc tagaacttaa gtttgatctg     4140

tcagccagta ctcccattaa attcagtgta gtttcacttg atagaatcag atatgttatc     4200

gaaatgttag cagcagcttc atcctccttc tgattaaagt aagtagaaat gggatgtttt     4260

gtttaataac agccatagtg tgtgtttaga ccacagcgga tgttgtagac caggaccata     4320

gatgatacat gtcagtgctg tggaatgtgc attctctgag tgttgttttg tggtatcatt     4380

gtctttcctg aatgactttc taactgtgca gaaaggcaga aaagtcatca tatgtatatg     4440

tcatatgact ttataaaata tttaatgtga caaaaagtgg aaagaatctt tacaaaccct     4500

gcaattactt ttttaaaggc acttttactc tttggtttta tcattccatt ttgctaatat     4560

ttactagctt tataaattac agtaaggtac aaaaactcat cttgtaatat tttcattttt     4620

gaagtgaaaa agtacatata ttttgcacaa ggttttatac tgctaagtgc ttggttgggg     4680

tggtgagatg atgattagat caggggtgag gctgagagac tctgggttta gggctagccc     4740

tgcctccatc tcccttgggt aaaatgaagg gtgtggggta aaagatgcat aaggcctttt     4800

ctagctctga cagcctagaa gtccaatcac cctgtaataa atatgtgttg aatgaagaaa     4860

tgggtgaatg agcttgtcaa tgtgatttta aaaaattgac tacctggagg aatgattagg     4920

aatctaaatg aagccagccc tcggtatctg caggtttctc atccatggat tcaaccaact     4980

gcaaatggaa aatacgattt tttttaaaaa aaggatggtt acatccgtat tgaacatgta     5040

cagacttttt tcttgtcatt attctctgaa caatacaaga actctttatg tagcatttac     5100

atttattagg tattataagt aatctagaga ttatttaatt aaaatataca ggaggatgtg     5160

tgtcagttat atgcaaattc tgtaccattt tgtatcaggg aattgagcat cttcagatgt     5220

tggtatctgc agggatcctg gaaccaaacc cctgcagata ctaagggctg acgatctagg     5280

taagactgga tttaacagtt ggaaaaaaaa aaaaaaaagg agagagaaga cagttccttt     5340

cctgtagaaa ttaaaacaaa atacaaattg aggaagctct gctacccagg ctgtcatggt     5400

agagaacttg aagaagacct gtttggatgg acacctggtt tcaaaagtca ggtgtggaga     5460

ctgttaaatg ggagggcctc atccataaat gatttctggc aacgtcttct tcaggtggag     5520

cttgacgtct ttttaatgtt acttggggag ggagtgctca ttaagggatg ccagggccag     5580

ctctggtggt tcctggggag gctgcgtcct tccctgcttc tgcatgtcat gaggcagcag     5640

gaaggtttcc cctgcacctg tctgtcctgg ctccctctgg gtagccccct actgttctgt     5700

gcttcagcac agcctggttt gtcaagaggc acatagttgg ggctgggctg catggcacag     5760

gggcttatgt gcctgctggt tatttaattt tcagccttaa gttttcttta atattttcct     5820

gttggctatt taaaggtttt ggttatcttt tattccttat ctacaatcaa gatgacaatg     5880

taattgaatt atcttattta taacacggtt cgtgattcat gattcatgat tacaagtaga     5940

aaatatgtca tgttcctcac ctccaaataa atatgtgtgt gtctgtgtgt gtgtatatat     6000

gtatgtggcg gagagggaga gagtggggaa ggagagcagt gttatcatac atagagaggc     6060

taaatgtgtc ccatccctca ctgtcagctt tataaaggag tttgactcca tccacagaag     6120

aatgttttat aagactagga aaacacgttg aaaactagga taaacagcaa caaaaatcaa     6180

ctaaatatgt tgttactgtt gctaaggatt ttctccttag aataatttag gatttttaaa     6240

aatttctgtt tgccaaatgc tgtagataaa tggccagatt cttcctatcc ctaggattcc     6300

tttattattt tttttcacag attttgagaa caagggggag agatagtatg gaagattaag     6360

attccattaa tcttatagaa ctgtgttgtc acccaaattc ctgcttgttt gaacatggca     6420

tcttcataga ttcaggattc actaccctct atagctggat cttgaaaatt atctggccag     6480

ataattttgc atctgcttgg atgattgtag actgagatgt gagtggagga taaagtatta     6540

gacttttgct gagtaactgc caaccaagaa gtatttatcg gacacttact aggtgcctag     6600

gattgtatca gagggaatat gaaatgtgtc cctgccctac ctagttttaa cgacagaata     6660

tctattaaag gctacttagc tgaagggtaa gggtgacagg tctaggggaa gctttgggag     6720

gtggtgtgct gtgacagaaa aagtggcaga gtagggacga gagacctgca ttctagccct     6780

gtttctgtca cttgctctgt acacttagac aacagcttga cctcttgagc tttagtttcc     6840

tcctctgcat aatgagaggg ttagactact gaattgtatg ggaaaaaaat acaaattcct     6900

gggtcctagg ccatgcctgc tgaatccgac tgttcaggaa gaggcctagg aaatctgtga     6960

gggaatcccc aggggaatct cgtgaccagc caggtgtgaa atctgctaac tggaagatct     7020

caaagcttcc ttcacttttt gtgattttgt ggtcatgtaa cgttactgta ttattctacg     7080

taaatgtggg tacttggatg tttatcatac tgtttctctg tgtttacata ctaatttgtg     7140

taagaaatgc attttagtct gtgtacctca acctgctgtt tgtttcctag aggtgttagt     7200

agtctttaaa tacaagtaag acttaagagg atatttgatg ttatttacct ggatattttc     7260

ttcccctttt atttatttag aggaaattga gattctagga gccaaaaaaa tgaaaacaaa     7320

attctaaggc aaagttaaag aaaaaaatta cattatttct taccatttgc tactttataa     7380

tgaaaattta aaaattatat gggaagattt ttctctggga taacaaatcc ttgtcataaa     7440

gtaagaggtc tttttaaagt aggtaggcta taaggcctgt aatttaaaat aatactcctt     7500

tctctagggt ttggtgcaat tctccattaa tgaagataac atttgaattc cccaaagcag     7560

gtgaggagtc ggggaggaga aagcgatgtt aaaatgaaaa ctcactgcaa aagaggaggc     7620

agaggaagaa ggaatgtaaa ccccttaaag cagatgtgtg tggggcctta tgaagaccag     7680

gattctgcgg gtgtcagggg attgcccctc ttgacagaga ctagggtttt agactgaggc     7740

ttcctgcagg gtgttcgcat tgcccttctc cgttcccctt cagacctttc tggggagaag     7800

aggtgggagg aggggagaaa gactgttcat cttattctga atcctggagc agctgaaggt     7860

tttctcttga gtcaggatgc agtggtaatg cattaaccag caagtgtggc caaggataat     7920

gaaaaagtgg gaaaggaagg tcctcctcct ccctgattgt agcatccagc agtctctgta     7980

gccaggttac tcaagaacca catttgattt cctggccctt tgccttggca gtgatggcat     8040

ttttatttca ctgtgtttta aagtcttcat ttatttttat aacatgggtt agggagaagg     8100

gccacaaatg gagggattgt cctttcaagc accacagctt cagataaaat tagtactttc     8160

aaatattgtc cactttaact taaaaaattc tagagggatt atattggaga ctcaactgcc     8220

cttggtttta gtttataaaa tggcctagta ctgtggaatt ttaattttag aaagtcttag     8280

catcagatca taaacattca ttaaaagaac tcacatccca tctgaaactt cccaggggag     8340

ttgggattct tagtagattg gtagaaaggg gctcattttc tactgcattt cccatttttg     8400

gtatcttgtt cagcatgttt tatttttatt tcttgtctgc agaacatcct atatttatga     8460

gaacattctt taagaagacc accacataga ataccccttc ctatcagctc gctctgattt     8520

agccttaatt ttgttaaatt ttttagagat gaatgaagtg ctgctgtgga aagaaatgta     8580

catatactat ttctgtatca ttaaaattac atttttatgg ttc                       8623


<210>  41
<211>  955
<212>  PRT
<213>  Mus musculus

<400>  41

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Val Pro Ser Thr Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Leu Ser Leu 
            100                 105                 110         


Phe Arg Asn Arg Leu Arg Leu Ser Lys Gly Leu Gln Val Asp Val Gly 
        115                 120                 125             


Ser Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Asn Gly Leu Glu Ser Asp Phe Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Pro Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Ser Thr Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Ser Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Asp Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Val Thr Gly Ser Thr Ser Asp Pro Gly Ser Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Gln Ser 
        355                 360                 365             


Lys Ser Lys Asn Pro Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala 
    370                 375                 380                 


Lys Ser Leu Thr Glu Met Ser Ser Asp Phe Gly His Ser Ser Pro Pro 
385                 390                 395                 400 


Pro Gln Pro Pro Ser Met Asn Ser Leu Ser Ser Glu Asn Arg Phe His 
                405                 410                 415     


Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Met 
            420                 425                 430         


Ala His Ser Pro Leu Ser Leu Ser Val Gln Ser Val Met Gly Glu Leu 
        435                 440                 445             


Asn Ser Thr Pro Val Gln Glu Ser Pro Pro Leu Pro Ile Ser Ser Gly 
    450                 455                 460                 


Asn Ala His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn 
465                 470                 475                 480 


Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu 
                485                 490                 495     


Ser Asp Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys 
            500                 505                 510         


Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys 
        515                 520                 525             


Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe 
    530                 535                 540                 


Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu 
545                 550                 555                 560 


Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro 
                565                 570                 575     


Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly 
            580                 585                 590         


Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys 
        595                 600                 605             


Leu Phe Ala Phe Ser Ser Ala Leu Asp Thr Val Leu Leu Arg Pro Lys 
    610                 615                 620                 


Glu Lys Asn Asp Ile Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg 
625                 630                 635                 640 


Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr 
                645                 650                 655     


Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser 
            660                 665                 670         


Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu 
        675                 680                 685             


Phe His Asp Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala 
    690                 695                 700                 


Gly Gln Lys Val Gln Asp Cys Asn Phe Tyr Gln Ile Phe Met Glu Lys 
705                 710                 715                 720 


Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser 
                725                 730                 735     


Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile 
            740                 745                 750         


Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile 
        755                 760                 765             


Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro 
    770                 775                 780                 


Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu 
785                 790                 795                 800 


Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys 
                805                 810                 815     


Lys Thr Cys Ser Thr Gln Val His Leu His Pro Arg Arg Leu Asn His 
            820                 825                 830         


Ser Tyr His Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp 
        835                 840                 845             


Arg His Gly Cys Ile Pro Cys Gln Lys Met Glu Leu Phe Ala Val Leu 
    850                 855                 860                 


Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp 
865                 870                 875                 880 


Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly 
                885                 890                 895     


Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly 
            900                 905                 910         


Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg 
        915                 920                 925             


Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys 
    930                 935                 940                 


Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955 


<210>  42
<211>  8023
<212>  DNA
<213>  Mus musculus

<400>  42
agttcggagg cggggcaggt gggggcgggc ccaggtagca ggttcggctg cgcgggggcc       60

cgcgcgcctg aggcactttg aattgctgtc tttttacaac atggatgcca ggttgctaaa      120

atcttgcttt gggacttaca gcgagttcat ttttttggat tttatgacag atttactagt      180

ggctcctttt tgccagtcaa tgttctgaaa gttactgtca caatgagttc aggcctgtgg      240

agccaagaga aagttacttc accctactgg gaagaacgga ttttttatct gcttcttcaa      300

gaatgcagtg taacagacaa acaaactcag aagctgctga aagtacccaa agggagtata      360

ggacagtaca tccaagaccg ttctgtgggg cattcaagag ttccttccac aaaaggcaag      420

aaaaatcaga ttggattaaa aatcttggag caaccgcatg cagttctgtt tgttgatgaa      480

aaggatgttg tagaaataaa tgaaaaattc acagagttac tgttggcaat taccaactgt      540

gaggagaggc tcagcctatt tagaaacaga ctccgactaa gtaaaggcct ccaggtagac      600

gtgggcagtc ctgtgaaagt acagctgcga tctggggaag agaaatttcc aggagttgta      660

cgcttcagag gacctttatt agcggagagg acggtgtcgg ggattttctt tggagtagaa      720

ttattggaag aaggtcgtgg tcaaggtttc acggatgggg tatatcaagg gaagcagctt      780

ttccagtgtg atgaggactg tggcgtgttt gttgcattgg acaaactaga acttatagaa      840

gatgatgaca atggattgga aagtgatttt gcaggcccag gagatacaat gcaggttgaa      900

cctccccctt tggaaataaa ctccagagtt tctttgaagg ttggagaaag tacagaatct      960

ggaacagtaa tattctgtga tgttttacca ggaaaagaga gtctaggata ttttgttggt     1020

gtggacatgg ataaccctat tggcaactgg gatggaaggt ttgatggagt acagctctgt     1080

agttttgcaa gtgttgaaag tacaattctc ctgcacatca atgacatcat cccagcttta     1140

tcagatagcg tgacacagga aaggaggcct cccaaacttg cctttatgtc aagaggtgta     1200

ggtgacaaag gttcatctag tcataataaa ccaaaggtta caggatctac ctcagaccct     1260

ggaagtagaa acagatctga attattttat accttaaatg ggtcatctgt tgactcacaa     1320

caatccaagt ccaaaaatcc atggtacatt gatgaagttg cagaagaccc tgcaaagtca     1380

cttacagaga tgtcttcgga cttcggacat tcatctcctc caccgcagcc tccttccatg     1440

aactccttgt ctagcgagaa cagattccac tccttaccct tcagcctgac aaagatgccc     1500

aatactaatg gcagcatggc tcatagtcca ctctctctgt cagtgcagtc tgtgatgggg     1560

gagctgaaca gcacacctgt ccaggagagt ccacccttgc ccatctcttc tgggaatgca     1620

cacgggctag aggtgggctc actggctgaa gtaaaagaga accccccgtt ctatggggtt     1680

atccgttgga ttggccagcc accagggctc agtgacgtgc tagctggact ggaactggaa     1740

gatgaatgcg caggctgtac agatggaact ttcaggggca cgcggtattt cacgtgtgcc     1800

ctgaagaagg cactgtttgt gaaactgaag agctgcagac cggactctag gtttgcatcc     1860

ttgcagcctg tttccaatca aattgaaagg tgtaactctt tagcatttgg gggctattta     1920

agtgaagtag tagaagaaaa tactccacct aaaatggaaa aggaaggttt agagataatg     1980

attggaaaga agaaaggcat ccagggccat tacaattctt gttacttaga ctcaacttta     2040

ttctgcttat ttgcttttag ttctgccctg gacactgtgt tacttagacc caaagagaag     2100

aatgatatag agtattacag tgagactcag gagctactga ggacagagat agtcaatcct     2160

ctgagaatat atggatatgt gtgtgccaca aagattatga aactgaggaa aatacttgaa     2220

aaagttgagg ctgcatcagg ttttacctct gaagaaaaag atcctgaaga attcttaaat     2280

atcctgtttc atgatatttt aagggttgaa ccattgttaa aaataagatc agcaggtcaa     2340

aaagttcaag actgtaactt ctatcaaatt tttatggaaa aaaatgagaa agttggagta     2400

cccacaattc agcagttatt agaatggtct tttatcaaca gcaacctgaa atttgcagag     2460

gcaccatcat gcttgattat ccagatgcct cggtttggaa aagactttaa actatttaaa     2520

aaaatttttc cttccctgga attaaatata acagatttac ttgaagacac tcccaggcag     2580

tgccgcatct gtggaggact tgcgatgtac gagtgcaggg agtgctatga cgatccggac     2640

atctcagctg ggaagatcaa gcagttctgt aagacctgca gcactcaggt tcaccttcat     2700

cccaggaggt tgaatcattc ttatcatcca gtatcacttc ccaaagactt gcctgactgg     2760

gactggagac acggctgcat cccctgtcag aagatggagt tatttgctgt tctctgcata     2820

gaaacgagcc actatgttgc ttttgtgaag tatgggaagg atgactctgc ctggcttttc     2880

tttgacagca tggcggatcg agatggtggt cagaatggct tcaacattcc acaagtgacg     2940

ccctgcccag aagtgggaga gtacttgaag atgtctctgg aggacctgca ctctttggat     3000

tccagaagga ttcaaggctg tgcgcgcaga cttctttgcg atgcatacat gtgcatgtac     3060

cagagtccaa ccatgagcct gtacaaataa ccaggttatc cgcagtgggc agagacagca     3120

caaaccttag tgctgtgtct tcctccagct tgtggttctg tccggcaccc attgccggca     3180

atgggtgtct cttttgatga tggcccttca gcaaaggatt cctgtgtttc caaacaaatt     3240

gcttttgtgt tcctgaagta tttaataaga agcattttgc actctaggaa gtatgtttgt     3300

gttgattttt taagaagtct aaatggattt attaatatct gacactttaa gttaactgca     3360

ttgatgatac gatatttttg gaagcataca attttaattg tgacgtctaa aacctctttt     3420

agtccattga ggatgtaaat aaatatttct tcttatggac cagggatatg aaatcatttt     3480

ccttttgtag ctaatgattg ccttgagaaa gacataatat gattttatta agagtctgcc     3540

tttactccaa ttgttgaagg tgtgctgagt ttaattgtta attttcctat atagtgctga     3600

tttcctgcat gtctgtactt tgctgagttt ctgtgttcct gcagcagtgg tcagaacatg     3660

ctgaaattcc tttcatggtg ttatttttta tttgttctag ttttgagata aatgagtgac     3720

tctgtcataa aatgtccatt tttgatttgt tcttgaagaa ttagggtaca aaacaagtat     3780

cgtagtcata gtaacaactg ttactgaaca ggtcttctgt aggggctcct aagtatgaga     3840

caacatgcag tggtttctga aatgactgag cgataagtaa attatatatt ctttttttaa     3900

aagatttatt ttatttatat gagtacactg tagctgtctt cagacacacc agaagagggc     3960

atcagatctt attacagatg gttgtgagcc accatgtggt tgctgggaat tgaactcagg     4020

acctttggaa gggcagtcag tgctcttaac tgctgagcta tctctctagc cccaaattat     4080

atattcttat acagacccac agtccagaga aagtgaagct ggctcagagt tagcaccaac     4140

atttccctga aaaaatgtgt taggtgttta aaaatctcat cgtaaataaa ttattttatt     4200

tttagtttaa gtgaatttct cttaatttaa ataagactaa tatttttgtt tgactgaaga     4260

cccttgtact ctctggtgtc agtttggtgt cacttgaaac aatgacaacc acgtcagcat     4320

gttactgcaa tgtcagtgat ggtttcaaag gagaaaatgg atgtcatctt aggactgctt     4380

gtgtgtgtat agaccgtggt ggatgctgta gagtgcttgt tgtctgagtg ttgttttgtg     4440

gtatggctgt ctctctgaat aatgtcaacc ttacagaaag agaaggtgtt atatgtgtaa     4500

catatggctt tataaaagat ttaatgtcaa aagagtctat aaatattgct gttattttta     4560

aaggcacttt actccttggt tttattattc cattttgctg gcgtgtatta gctttatata     4620

aatcacaaca cacaaaactc gtccatcttg taatctttgt acttttgcaa tggaaaagtg     4680

tgtatactgt gcacagactt ttatatagct gagtgcctag actgggtgga gaggccatga     4740

gtagatagca gtaaagtcct ccagctatag gctagccttg tcttcatcat cctgggacag     4800

gtgagaacgg tgagcacagg tgagtctgag cttgcacact gaccagaatt cagtcaccct     4860

gtaataagta tgtatttaat gagtctgtta gtgtggtagt gtgattttga aaggtttaac     4920

taaggaatgg tgaggtcttt gtttataggc aagcctggct taacagtgaa ggggaggggg     4980

ctgagggaaa gctttttttt tttttaattt cagaaatgga agcaaaatcc atgtgcaaag     5040

agactagcta cttggctttc agagcagagg actcaaagct tgtttgcagt ggttctgaag     5100

ttggggtggc actttgtgag tgaggaggac catgtccaca ggcaatccct aagcaagatc     5160

gtctcgaaat tgcactgtgt tctttagcag tagtggctgg gtaggggcac acagcggaac     5220

acccacttgc agtggctggg gaggcctgag aagcacaggc cagcgggagc tctctcccat     5280

gccttcttgt ccctctggac agcccctcct cattccttgt cccagcagag cctggtttgc     5340

ccctggggca atagggttgg actgtgtggt gcagatagcc ctcgtgcctg tggattactt     5400

taattttgta atcttaggtt ttctgtacgg ttttcccatt gccttttaaa atattttgag     5460

tgtccttctc cttatcaaga tggtagtgta gtaggattgt tttactcaca acatggttta     5520

ggagccatag ctacaaatag gaaatataag aattctattt ctctactgtg aggcaaatct     5580

gtatatatgt atggagagtc aggaggatga acaagggaga ggaaaggggc ccaggcacat     5640

ttttaatcca aaagctacaa agtgtcgagc tcctcagggc cagcttcaca gagagtccag     5700

ctcagttcac aaagtatttt ctaagttggg gaaatgcatt gagaaacaga gcgagatatc     5760

tgtgtagtgc agctgtgggt ggttgctatg cattttatcc tcagagtagc ctggggtttt     5820

tattttatgt ttgccaagtg cttaggtaaa tggccgggct cctcttacct ctgacttctg     5880

gagcgtgtcc attctctggt tgactgaatg tggcattttc ataaatctag gagcagcagc     5940

cctcccaact gcaatttagt aagcaggtag ataagcttgc atctgtttgc atcttcctgc     6000

actgagttgg gagtgcaaaa ccccgtactt ggcctggtga gtaactgcca acaagtattt     6060

atgggtcatt tgctaggtgg ctagcatacg gcacggggct aatgagacct ggggcctgct     6120

ctcatatagc ttactgctca gtttctatac cagagcatcc gttggtgctt cttagcctag     6180

gcatgggtga caggcatgtc tggggaccac tttgggagac aacctagtgt aaccttattg     6240

caaaggacta agagacaaaa atcctgggtt ctttctccat cacttgctct gtagctgaat     6300

gaacaccacc tcgatttctt gagtttcagt gtcttgttct gtctgatgaa agggttggat     6360

atgtagttgg ataagcggta caaattgtta gggttccagg ccatgcctga tacatctgag     6420

tttttgctgg aggtaggaaa tttcaactca gaagctcatc cacagaaaac agtgaccagc     6480

agcaggtatg gagccataag gctggaaggc ttcaaagacc ccttcttctg ttactgttat     6540

ccacggcagt tattctgtgt aggtgtgaag gagtggctac tgactctgtg tggatcagcg     6600

tttacatatg acctgatggg agtgcatctg gtatgtgttc ctcccccctg tattgctgga     6660

gagattggca atcgtaggta tacacggaag tgtcgggatg ttcagtggcg cgcacttgga     6720

tgtttctttt cactttattt ctatagaaac aggttccagg agccagagaa gtaggggaaa     6780

aaatccctga gctcatctct ctctactact taataatgca aacatttaaa ttcttgggaa     6840

gattttcccg ccccactccc tacccccagt cacaggtcag aataggattt ccttcttaga     6900

gaaggtaggt catggggcct gcgattaaaa aaacaaaaac ataaaacaaa caaacaaaca     6960

aggtggcttt ccttggtctt tgtgattcca gctcttcacc agtgaaggaa ttctttagtt     7020

ccatagtgca gcctgggtgg gtggagaaga ggctgttata gtgggagcca gtgagcaaag     7080

agggttggag gaggcagagg acagggctca gggaaggcaa gcctgtggct ctgggcattg     7140

gccctcttgt caaaggtgtc agagcatggc ttcctgtgag gggctttccc ttgctcctgt     7200

gtgagaatct gtgcgttgtc ttactggatg ggggacctgg atggagatgt taggggagat     7260

agcttagtct tgttctaaac tctagacttg ctaaaaaggg ttctcttgag tccaaatgca     7320

gtgccagagg gtgagaagca gaattggcca gtagtgaaca gtggtattgt gggtgataag     7380

ccctttctgg tggccttaaa tagcagtgct agtccttgag tgccacaggg tcccctacct     7440

ccgtcctggc agtgctgatg ggtttgtttc agcatatttt ggttctcatt ctcatttagg     7500

gaaaagggct gttgatgaag ggattatcct cccaggcacc aggggcctca gcacagttcc     7560

ctgtgctttt aaacactgtt gactttcatt agttattcta aagggattta tattggagat     7620

acaactccct ttggtttcat attatgaaat agctttgtac tgtggaatgc taactctgga     7680

aagtctccct cataccagaa ccaaacattc atttctttta tatatatata tatattatct     7740

ccctggtact ctccagggag gtggttatta tcaagctgac ccaaaggagt gcagtatgtg     7800

ttctagttcc ttttctggta ccttgttcaa cattcttttt tcctgaagaa catccttttg     7860

tttatgaaaa cgtgaatagc atcatgtaaa acaatccctt gctatcagaa tgctccagtt     7920

tggccttaat tttgtaaacc ttggagagga gtggagcgcg gctgtgagaa gagatgtacc     7980

atgtactctt tctgtatcat taaagtgcag tttttatgct tct                       8023


<210>  43
<211>  952
<212>  PRT
<213>  Mus musculus

<400>  43

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Val Pro Ser Thr Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Leu Ser Leu 
            100                 105                 110         


Phe Arg Asn Arg Leu Arg Leu Ser Lys Gly Leu Gln Val Asp Val Gly 
        115                 120                 125             


Ser Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Asn Gly Leu Glu Ser Asp Phe Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Pro Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Ser Thr Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Ser Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Asp Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Val 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Ser Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Gln Ser Lys Ser Lys 
        355                 360                 365             


Asn Pro Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser Leu 
    370                 375                 380                 


Thr Glu Met Ser Ser Asp Phe Gly His Ser Ser Pro Pro Pro Gln Pro 
385                 390                 395                 400 


Pro Ser Met Asn Ser Leu Ser Ser Glu Asn Arg Phe His Ser Leu Pro 
                405                 410                 415     


Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Met Ala His Ser 
            420                 425                 430         


Pro Leu Ser Leu Ser Val Gln Ser Val Met Gly Glu Leu Asn Ser Thr 
        435                 440                 445             


Pro Val Gln Glu Ser Pro Pro Leu Pro Ile Ser Ser Gly Asn Ala His 
    450                 455                 460                 


Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro Phe 
465                 470                 475                 480 


Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Ser Asp Val 
                485                 490                 495     


Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp Gly 
            500                 505                 510         


Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala Leu 
        515                 520                 525             


Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser Leu 
    530                 535                 540                 


Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe Gly 
545                 550                 555                 560 


Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met Glu 
                565                 570                 575     


Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly 
            580                 585                 590         


His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala 
        595                 600                 605             


Phe Ser Ser Ala Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys Asn 
    610                 615                 620                 


Asp Ile Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile 
625                 630                 635                 640 


Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met 
                645                 650                 655     


Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Thr 
            660                 665                 670         


Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His Asp 
        675                 680                 685             


Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys 
    690                 695                 700                 


Val Gln Asp Cys Asn Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys 
705                 710                 715                 720 


Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn 
                725                 730                 735     


Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met 
            740                 745                 750         


Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser 
        755                 760                 765             


Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys 
    770                 775                 780                 


Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp 
785                 790                 795                 800 


Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys 
                805                 810                 815     


Ser Thr Gln Val His Leu His Pro Arg Arg Leu Asn His Ser Tyr His 
            820                 825                 830         


Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly 
        835                 840                 845             


Cys Ile Pro Cys Gln Lys Met Glu Leu Phe Ala Val Leu Cys Ile Glu 
    850                 855                 860                 


Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly 
                885                 890                 895     


Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu 
            900                 905                 910         


Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile Gln 
        915                 920                 925             


Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln 
    930                 935                 940                 


Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950         


<210>  44
<211>  8148
<212>  DNA
<213>  Mus musculus

<400>  44
agttcggagg cggggcaggt gggggcgggc ccaggtagca ggttcggctg cgcgggggcc       60

cgcgcgcctg agcagtgagc tcctatgtca tggattctga actggcttat aatatctggc      120

atggattcct tttagcagag caggcctcaa atccgataga gcatggttgc ttgatcccat      180

tgcagccctg ccactagtgg ctcctggcac tttgaattgc tgtcttttta caacatggat      240

gccaggttgc taaaatcttg ctttgggact tacagcgagt tcattttttt ggattttatg      300

acagatttac tagtggctcc tttttgccag tcaatgttct gaaagttact gtcacaatga      360

gttcaggcct gtggagccaa gagaaagtta cttcacccta ctgggaagaa cggatttttt      420

atctgcttct tcaagaatgc agtgtaacag acaaacaaac tcagaagctg ctgaaagtac      480

ccaaagggag tataggacag tacatccaag accgttctgt ggggcattca agagttcctt      540

ccacaaaagg caagaaaaat cagattggat taaaaatctt ggagcaaccg catgcagttc      600

tgtttgttga tgaaaaggat gttgtagaaa taaatgaaaa attcacagag ttactgttgg      660

caattaccaa ctgtgaggag aggctcagcc tatttagaaa cagactccga ctaagtaaag      720

gcctccaggt agacgtgggc agtcctgtga aagtacagct gcgatctggg gaagagaaat      780

ttccaggagt tgtacgcttc agaggacctt tattagcgga gaggacggtg tcggggattt      840

tctttggagt agaattattg gaagaaggtc gtggtcaagg tttcacggat ggggtatatc      900

aagggaagca gcttttccag tgtgatgagg actgtggcgt gtttgttgca ttggacaaac      960

tagaacttat agaagatgat gacaatggat tggaaagtga ttttgcaggc ccaggagata     1020

caatgcaggt tgaacctccc cctttggaaa taaactccag agtttctttg aaggttggag     1080

aaagtacaga atctggaaca gtaatattct gtgatgtttt accaggaaaa gagagtctag     1140

gatattttgt tggtgtggac atggataacc ctattggcaa ctgggatgga aggtttgatg     1200

gagtacagct ctgtagtttt gcaagtgttg aaagtacaat tctcctgcac atcaatgaca     1260

tcatcccaga tagcgtgaca caggaaagga ggcctcccaa acttgccttt atgtcaagag     1320

gtgtaggtga caaaggttca tctagtcata ataaaccaaa ggttacagga tctacctcag     1380

accctggaag tagaaacaga tctgaattat tttatacctt aaatgggtca tctgttgact     1440

cacaacaatc caagtccaaa aatccatggt acattgatga agttgcagaa gaccctgcaa     1500

agtcacttac agagatgtct tcggacttcg gacattcatc tcctccaccg cagcctcctt     1560

ccatgaactc cttgtctagc gagaacagat tccactcctt acccttcagc ctgacaaaga     1620

tgcccaatac taatggcagc atggctcata gtccactctc tctgtcagtg cagtctgtga     1680

tgggggagct gaacagcaca cctgtccagg agagtccacc cttgcccatc tcttctggga     1740

atgcacacgg gctagaggtg ggctcactgg ctgaagtaaa agagaacccc ccgttctatg     1800

gggttatccg ttggattggc cagccaccag ggctcagtga cgtgctagct ggactggaac     1860

tggaagatga atgcgcaggc tgtacagatg gaactttcag gggcacgcgg tatttcacgt     1920

gtgccctgaa gaaggcactg tttgtgaaac tgaagagctg cagaccggac tctaggtttg     1980

catccttgca gcctgtttcc aatcaaattg aaaggtgtaa ctctttagca tttgggggct     2040

atttaagtga agtagtagaa gaaaatactc cacctaaaat ggaaaaggaa ggtttagaga     2100

taatgattgg aaagaagaaa ggcatccagg gccattacaa ttcttgttac ttagactcaa     2160

ctttattctg cttatttgct tttagttctg ccctggacac tgtgttactt agacccaaag     2220

agaagaatga tatagagtat tacagtgaga ctcaggagct actgaggaca gagatagtca     2280

atcctctgag aatatatgga tatgtgtgtg ccacaaagat tatgaaactg aggaaaatac     2340

ttgaaaaagt tgaggctgca tcaggtttta cctctgaaga aaaagatcct gaagaattct     2400

taaatatcct gtttcatgat attttaaggg ttgaaccatt gttaaaaata agatcagcag     2460

gtcaaaaagt tcaagactgt aacttctatc aaatttttat ggaaaaaaat gagaaagttg     2520

gagtacccac aattcagcag ttattagaat ggtcttttat caacagcaac ctgaaatttg     2580

cagaggcacc atcatgcttg attatccaga tgcctcggtt tggaaaagac tttaaactat     2640

ttaaaaaaat ttttccttcc ctggaattaa atataacaga tttacttgaa gacactccca     2700

ggcagtgccg catctgtgga ggacttgcga tgtacgagtg cagggagtgc tatgacgatc     2760

cggacatctc agctgggaag atcaagcagt tctgtaagac ctgcagcact caggttcacc     2820

ttcatcccag gaggttgaat cattcttatc atccagtatc acttcccaaa gacttgcctg     2880

actgggactg gagacacggc tgcatcccct gtcagaagat ggagttattt gctgttctct     2940

gcatagaaac gagccactat gttgcttttg tgaagtatgg gaaggatgac tctgcctggc     3000

ttttctttga cagcatggcg gatcgagatg gtggtcagaa tggcttcaac attccacaag     3060

tgacgccctg cccagaagtg ggagagtact tgaagatgtc tctggaggac ctgcactctt     3120

tggattccag aaggattcaa ggctgtgcgc gcagacttct ttgcgatgca tacatgtgca     3180

tgtaccagag tccaaccatg agcctgtaca aataaccagg ttatccgcag tgggcagaga     3240

cagcacaaac cttagtgctg tgtcttcctc cagcttgtgg ttctgtccgg cacccattgc     3300

cggcaatggg tgtctctttt gatgatggcc cttcagcaaa ggattcctgt gtttccaaac     3360

aaattgcttt tgtgttcctg aagtatttaa taagaagcat tttgcactct aggaagtatg     3420

tttgtgttga ttttttaaga agtctaaatg gatttattaa tatctgacac tttaagttaa     3480

ctgcattgat gatacgatat ttttggaagc atacaatttt aattgtgacg tctaaaacct     3540

cttttagtcc attgaggatg taaataaata tttcttctta tggaccaggg atatgaaatc     3600

attttccttt tgtagctaat gattgccttg agaaagacat aatatgattt tattaagagt     3660

ctgcctttac tccaattgtt gaaggtgtgc tgagtttaat tgttaatttt cctatatagt     3720

gctgatttcc tgcatgtctg tactttgctg agtttctgtg ttcctgcagc agtggtcaga     3780

acatgctgaa attcctttca tggtgttatt ttttatttgt tctagttttg agataaatga     3840

gtgactctgt cataaaatgt ccatttttga tttgttcttg aagaattagg gtacaaaaca     3900

agtatcgtag tcatagtaac aactgttact gaacaggtct tctgtagggg ctcctaagta     3960

tgagacaaca tgcagtggtt tctgaaatga ctgagcgata agtaaattat atattctttt     4020

tttaaaagat ttattttatt tatatgagta cactgtagct gtcttcagac acaccagaag     4080

agggcatcag atcttattac agatggttgt gagccaccat gtggttgctg ggaattgaac     4140

tcaggacctt tggaagggca gtcagtgctc ttaactgctg agctatctct ctagccccaa     4200

attatatatt cttatacaga cccacagtcc agagaaagtg aagctggctc agagttagca     4260

ccaacatttc cctgaaaaaa tgtgttaggt gtttaaaaat ctcatcgtaa ataaattatt     4320

ttatttttag tttaagtgaa tttctcttaa tttaaataag actaatattt ttgtttgact     4380

gaagaccctt gtactctctg gtgtcagttt ggtgtcactt gaaacaatga caaccacgtc     4440

agcatgttac tgcaatgtca gtgatggttt caaaggagaa aatggatgtc atcttaggac     4500

tgcttgtgtg tgtatagacc gtggtggatg ctgtagagtg cttgttgtct gagtgttgtt     4560

ttgtggtatg gctgtctctc tgaataatgt caaccttaca gaaagagaag gtgttatatg     4620

tgtaacatat ggctttataa aagatttaat gtcaaaagag tctataaata ttgctgttat     4680

ttttaaaggc actttactcc ttggttttat tattccattt tgctggcgtg tattagcttt     4740

atataaatca caacacacaa aactcgtcca tcttgtaatc tttgtacttt tgcaatggaa     4800

aagtgtgtat actgtgcaca gacttttata tagctgagtg cctagactgg gtggagaggc     4860

catgagtaga tagcagtaaa gtcctccagc tataggctag ccttgtcttc atcatcctgg     4920

gacaggtgag aacggtgagc acaggtgagt ctgagcttgc acactgacca gaattcagtc     4980

accctgtaat aagtatgtat ttaatgagtc tgttagtgtg gtagtgtgat tttgaaaggt     5040

ttaactaagg aatggtgagg tctttgttta taggcaagcc tggcttaaca gtgaagggga     5100

gggggctgag ggaaagcttt tttttttttt aatttcagaa atggaagcaa aatccatgtg     5160

caaagagact agctacttgg ctttcagagc agaggactca aagcttgttt gcagtggttc     5220

tgaagttggg gtggcacttt gtgagtgagg aggaccatgt ccacaggcaa tccctaagca     5280

agatcgtctc gaaattgcac tgtgttcttt agcagtagtg gctgggtagg ggcacacagc     5340

ggaacaccca cttgcagtgg ctggggaggc ctgagaagca caggccagcg ggagctctct     5400

cccatgcctt cttgtccctc tggacagccc ctcctcattc cttgtcccag cagagcctgg     5460

tttgcccctg gggcaatagg gttggactgt gtggtgcaga tagccctcgt gcctgtggat     5520

tactttaatt ttgtaatctt aggttttctg tacggttttc ccattgcctt ttaaaatatt     5580

ttgagtgtcc ttctccttat caagatggta gtgtagtagg attgttttac tcacaacatg     5640

gtttaggagc catagctaca aataggaaat ataagaattc tatttctcta ctgtgaggca     5700

aatctgtata tatgtatgga gagtcaggag gatgaacaag ggagaggaaa ggggcccagg     5760

cacattttta atccaaaagc tacaaagtgt cgagctcctc agggccagct tcacagagag     5820

tccagctcag ttcacaaagt attttctaag ttggggaaat gcattgagaa acagagcgag     5880

atatctgtgt agtgcagctg tgggtggttg ctatgcattt tatcctcaga gtagcctggg     5940

gtttttattt tatgtttgcc aagtgcttag gtaaatggcc gggctcctct tacctctgac     6000

ttctggagcg tgtccattct ctggttgact gaatgtggca ttttcataaa tctaggagca     6060

gcagccctcc caactgcaat ttagtaagca ggtagataag cttgcatctg tttgcatctt     6120

cctgcactga gttgggagtg caaaaccccg tacttggcct ggtgagtaac tgccaacaag     6180

tatttatggg tcatttgcta ggtggctagc atacggcacg gggctaatga gacctggggc     6240

ctgctctcat atagcttact gctcagtttc tataccagag catccgttgg tgcttcttag     6300

cctaggcatg ggtgacaggc atgtctgggg accactttgg gagacaacct agtgtaacct     6360

tattgcaaag gactaagaga caaaaatcct gggttctttc tccatcactt gctctgtagc     6420

tgaatgaaca ccacctcgat ttcttgagtt tcagtgtctt gttctgtctg atgaaagggt     6480

tggatatgta gttggataag cggtacaaat tgttagggtt ccaggccatg cctgatacat     6540

ctgagttttt gctggaggta ggaaatttca actcagaagc tcatccacag aaaacagtga     6600

ccagcagcag gtatggagcc ataaggctgg aaggcttcaa agaccccttc ttctgttact     6660

gttatccacg gcagttattc tgtgtaggtg tgaaggagtg gctactgact ctgtgtggat     6720

cagcgtttac atatgacctg atgggagtgc atctggtatg tgttcctccc ccctgtattg     6780

ctggagagat tggcaatcgt aggtatacac ggaagtgtcg ggatgttcag tggcgcgcac     6840

ttggatgttt cttttcactt tatttctata gaaacaggtt ccaggagcca gagaagtagg     6900

ggaaaaaatc cctgagctca tctctctcta ctacttaata atgcaaacat ttaaattctt     6960

gggaagattt tcccgcccca ctccctaccc ccagtcacag gtcagaatag gatttccttc     7020

ttagagaagg taggtcatgg ggcctgcgat taaaaaaaca aaaacataaa acaaacaaac     7080

aaacaaggtg gctttccttg gtctttgtga ttccagctct tcaccagtga aggaattctt     7140

tagttccata gtgcagcctg ggtgggtgga gaagaggctg ttatagtggg agccagtgag     7200

caaagagggt tggaggaggc agaggacagg gctcagggaa ggcaagcctg tggctctggg     7260

cattggccct cttgtcaaag gtgtcagagc atggcttcct gtgaggggct ttcccttgct     7320

cctgtgtgag aatctgtgcg ttgtcttact ggatggggga cctggatgga gatgttaggg     7380

gagatagctt agtcttgttc taaactctag acttgctaaa aagggttctc ttgagtccaa     7440

atgcagtgcc agagggtgag aagcagaatt ggccagtagt gaacagtggt attgtgggtg     7500

ataagccctt tctggtggcc ttaaatagca gtgctagtcc ttgagtgcca cagggtcccc     7560

tacctccgtc ctggcagtgc tgatgggttt gtttcagcat attttggttc tcattctcat     7620

ttagggaaaa gggctgttga tgaagggatt atcctcccag gcaccagggg cctcagcaca     7680

gttccctgtg cttttaaaca ctgttgactt tcattagtta ttctaaaggg atttatattg     7740

gagatacaac tccctttggt ttcatattat gaaatagctt tgtactgtgg aatgctaact     7800

ctggaaagtc tccctcatac cagaaccaaa cattcatttc ttttatatat atatatatat     7860

tatctccctg gtactctcca gggaggtggt tattatcaag ctgacccaaa ggagtgcagt     7920

atgtgttcta gttccttttc tggtaccttg ttcaacattc ttttttcctg aagaacatcc     7980

ttttgtttat gaaaacgtga atagcatcat gtaaaacaat cccttgctat cagaatgctc     8040

cagtttggcc ttaattttgt aaaccttgga gaggagtgga gcgcggctgt gagaagagat     8100

gtaccatgta ctctttctgt atcattaaag tgcagttttt atgcttct                  8148


<210>  45
<211>  8014
<212>  DNA
<213>  Mus musculus

<400>  45
agttcggagg cggggcaggt gggggcgggc ccaggtagca ggttcggctg cgcgggggcc       60

cgcgcgcctg aggcactttg aattgctgtc tttttacaac atggatgcca ggttgctaaa      120

atcttgcttt gggacttaca gcgagttcat ttttttggat tttatgacag atttactagt      180

ggctcctttt tgccagtcaa tgttctgaaa gttactgtca caatgagttc aggcctgtgg      240

agccaagaga aagttacttc accctactgg gaagaacgga ttttttatct gcttcttcaa      300

gaatgcagtg taacagacaa acaaactcag aagctgctga aagtacccaa agggagtata      360

ggacagtaca tccaagaccg ttctgtgggg cattcaagag ttccttccac aaaaggcaag      420

aaaaatcaga ttggattaaa aatcttggag caaccgcatg cagttctgtt tgttgatgaa      480

aaggatgttg tagaaataaa tgaaaaattc acagagttac tgttggcaat taccaactgt      540

gaggagaggc tcagcctatt tagaaacaga ctccgactaa gtaaaggcct ccaggtagac      600

gtgggcagtc ctgtgaaagt acagctgcga tctggggaag agaaatttcc aggagttgta      660

cgcttcagag gacctttatt agcggagagg acggtgtcgg ggattttctt tggagtagaa      720

ttattggaag aaggtcgtgg tcaaggtttc acggatgggg tatatcaagg gaagcagctt      780

ttccagtgtg atgaggactg tggcgtgttt gttgcattgg acaaactaga acttatagaa      840

gatgatgaca atggattgga aagtgatttt gcaggcccag gagatacaat gcaggttgaa      900

cctccccctt tggaaataaa ctccagagtt tctttgaagg ttggagaaag tacagaatct      960

ggaacagtaa tattctgtga tgttttacca ggaaaagaga gtctaggata ttttgttggt     1020

gtggacatgg ataaccctat tggcaactgg gatggaaggt ttgatggagt acagctctgt     1080

agttttgcaa gtgttgaaag tacaattctc ctgcacatca atgacatcat cccagatagc     1140

gtgacacagg aaaggaggcc tcccaaactt gcctttatgt caagaggtgt aggtgacaaa     1200

ggttcatcta gtcataataa accaaaggtt acaggatcta cctcagaccc tggaagtaga     1260

aacagatctg aattatttta taccttaaat gggtcatctg ttgactcaca acaatccaag     1320

tccaaaaatc catggtacat tgatgaagtt gcagaagacc ctgcaaagtc acttacagag     1380

atgtcttcgg acttcggaca ttcatctcct ccaccgcagc ctccttccat gaactccttg     1440

tctagcgaga acagattcca ctccttaccc ttcagcctga caaagatgcc caatactaat     1500

ggcagcatgg ctcatagtcc actctctctg tcagtgcagt ctgtgatggg ggagctgaac     1560

agcacacctg tccaggagag tccacccttg cccatctctt ctgggaatgc acacgggcta     1620

gaggtgggct cactggctga agtaaaagag aaccccccgt tctatggggt tatccgttgg     1680

attggccagc caccagggct cagtgacgtg ctagctggac tggaactgga agatgaatgc     1740

gcaggctgta cagatggaac tttcaggggc acgcggtatt tcacgtgtgc cctgaagaag     1800

gcactgtttg tgaaactgaa gagctgcaga ccggactcta ggtttgcatc cttgcagcct     1860

gtttccaatc aaattgaaag gtgtaactct ttagcatttg ggggctattt aagtgaagta     1920

gtagaagaaa atactccacc taaaatggaa aaggaaggtt tagagataat gattggaaag     1980

aagaaaggca tccagggcca ttacaattct tgttacttag actcaacttt attctgctta     2040

tttgctttta gttctgccct ggacactgtg ttacttagac ccaaagagaa gaatgatata     2100

gagtattaca gtgagactca ggagctactg aggacagaga tagtcaatcc tctgagaata     2160

tatggatatg tgtgtgccac aaagattatg aaactgagga aaatacttga aaaagttgag     2220

gctgcatcag gttttacctc tgaagaaaaa gatcctgaag aattcttaaa tatcctgttt     2280

catgatattt taagggttga accattgtta aaaataagat cagcaggtca aaaagttcaa     2340

gactgtaact tctatcaaat ttttatggaa aaaaatgaga aagttggagt acccacaatt     2400

cagcagttat tagaatggtc ttttatcaac agcaacctga aatttgcaga ggcaccatca     2460

tgcttgatta tccagatgcc tcggtttgga aaagacttta aactatttaa aaaaattttt     2520

ccttccctgg aattaaatat aacagattta cttgaagaca ctcccaggca gtgccgcatc     2580

tgtggaggac ttgcgatgta cgagtgcagg gagtgctatg acgatccgga catctcagct     2640

gggaagatca agcagttctg taagacctgc agcactcagg ttcaccttca tcccaggagg     2700

ttgaatcatt cttatcatcc agtatcactt cccaaagact tgcctgactg ggactggaga     2760

cacggctgca tcccctgtca gaagatggag ttatttgctg ttctctgcat agaaacgagc     2820

cactatgttg cttttgtgaa gtatgggaag gatgactctg cctggctttt ctttgacagc     2880

atggcggatc gagatggtgg tcagaatggc ttcaacattc cacaagtgac gccctgccca     2940

gaagtgggag agtacttgaa gatgtctctg gaggacctgc actctttgga ttccagaagg     3000

attcaaggct gtgcgcgcag acttctttgc gatgcataca tgtgcatgta ccagagtcca     3060

accatgagcc tgtacaaata accaggttat ccgcagtggg cagagacagc acaaacctta     3120

gtgctgtgtc ttcctccagc ttgtggttct gtccggcacc cattgccggc aatgggtgtc     3180

tcttttgatg atggcccttc agcaaaggat tcctgtgttt ccaaacaaat tgcttttgtg     3240

ttcctgaagt atttaataag aagcattttg cactctagga agtatgtttg tgttgatttt     3300

ttaagaagtc taaatggatt tattaatatc tgacacttta agttaactgc attgatgata     3360

cgatattttt ggaagcatac aattttaatt gtgacgtcta aaacctcttt tagtccattg     3420

aggatgtaaa taaatatttc ttcttatgga ccagggatat gaaatcattt tccttttgta     3480

gctaatgatt gccttgagaa agacataata tgattttatt aagagtctgc ctttactcca     3540

attgttgaag gtgtgctgag tttaattgtt aattttccta tatagtgctg atttcctgca     3600

tgtctgtact ttgctgagtt tctgtgttcc tgcagcagtg gtcagaacat gctgaaattc     3660

ctttcatggt gttatttttt atttgttcta gttttgagat aaatgagtga ctctgtcata     3720

aaatgtccat ttttgatttg ttcttgaaga attagggtac aaaacaagta tcgtagtcat     3780

agtaacaact gttactgaac aggtcttctg taggggctcc taagtatgag acaacatgca     3840

gtggtttctg aaatgactga gcgataagta aattatatat tcttttttta aaagatttat     3900

tttatttata tgagtacact gtagctgtct tcagacacac cagaagaggg catcagatct     3960

tattacagat ggttgtgagc caccatgtgg ttgctgggaa ttgaactcag gacctttgga     4020

agggcagtca gtgctcttaa ctgctgagct atctctctag ccccaaatta tatattctta     4080

tacagaccca cagtccagag aaagtgaagc tggctcagag ttagcaccaa catttccctg     4140

aaaaaatgtg ttaggtgttt aaaaatctca tcgtaaataa attattttat ttttagttta     4200

agtgaatttc tcttaattta aataagacta atatttttgt ttgactgaag acccttgtac     4260

tctctggtgt cagtttggtg tcacttgaaa caatgacaac cacgtcagca tgttactgca     4320

atgtcagtga tggtttcaaa ggagaaaatg gatgtcatct taggactgct tgtgtgtgta     4380

tagaccgtgg tggatgctgt agagtgcttg ttgtctgagt gttgttttgt ggtatggctg     4440

tctctctgaa taatgtcaac cttacagaaa gagaaggtgt tatatgtgta acatatggct     4500

ttataaaaga tttaatgtca aaagagtcta taaatattgc tgttattttt aaaggcactt     4560

tactccttgg ttttattatt ccattttgct ggcgtgtatt agctttatat aaatcacaac     4620

acacaaaact cgtccatctt gtaatctttg tacttttgca atggaaaagt gtgtatactg     4680

tgcacagact tttatatagc tgagtgccta gactgggtgg agaggccatg agtagatagc     4740

agtaaagtcc tccagctata ggctagcctt gtcttcatca tcctgggaca ggtgagaacg     4800

gtgagcacag gtgagtctga gcttgcacac tgaccagaat tcagtcaccc tgtaataagt     4860

atgtatttaa tgagtctgtt agtgtggtag tgtgattttg aaaggtttaa ctaaggaatg     4920

gtgaggtctt tgtttatagg caagcctggc ttaacagtga aggggagggg gctgagggaa     4980

agcttttttt ttttttaatt tcagaaatgg aagcaaaatc catgtgcaaa gagactagct     5040

acttggcttt cagagcagag gactcaaagc ttgtttgcag tggttctgaa gttggggtgg     5100

cactttgtga gtgaggagga ccatgtccac aggcaatccc taagcaagat cgtctcgaaa     5160

ttgcactgtg ttctttagca gtagtggctg ggtaggggca cacagcggaa cacccacttg     5220

cagtggctgg ggaggcctga gaagcacagg ccagcgggag ctctctccca tgccttcttg     5280

tccctctgga cagcccctcc tcattccttg tcccagcaga gcctggtttg cccctggggc     5340

aatagggttg gactgtgtgg tgcagatagc cctcgtgcct gtggattact ttaattttgt     5400

aatcttaggt tttctgtacg gttttcccat tgccttttaa aatattttga gtgtccttct     5460

ccttatcaag atggtagtgt agtaggattg ttttactcac aacatggttt aggagccata     5520

gctacaaata ggaaatataa gaattctatt tctctactgt gaggcaaatc tgtatatatg     5580

tatggagagt caggaggatg aacaagggag aggaaagggg cccaggcaca tttttaatcc     5640

aaaagctaca aagtgtcgag ctcctcaggg ccagcttcac agagagtcca gctcagttca     5700

caaagtattt tctaagttgg ggaaatgcat tgagaaacag agcgagatat ctgtgtagtg     5760

cagctgtggg tggttgctat gcattttatc ctcagagtag cctggggttt ttattttatg     5820

tttgccaagt gcttaggtaa atggccgggc tcctcttacc tctgacttct ggagcgtgtc     5880

cattctctgg ttgactgaat gtggcatttt cataaatcta ggagcagcag ccctcccaac     5940

tgcaatttag taagcaggta gataagcttg catctgtttg catcttcctg cactgagttg     6000

ggagtgcaaa accccgtact tggcctggtg agtaactgcc aacaagtatt tatgggtcat     6060

ttgctaggtg gctagcatac ggcacggggc taatgagacc tggggcctgc tctcatatag     6120

cttactgctc agtttctata ccagagcatc cgttggtgct tcttagccta ggcatgggtg     6180

acaggcatgt ctggggacca ctttgggaga caacctagtg taaccttatt gcaaaggact     6240

aagagacaaa aatcctgggt tctttctcca tcacttgctc tgtagctgaa tgaacaccac     6300

ctcgatttct tgagtttcag tgtcttgttc tgtctgatga aagggttgga tatgtagttg     6360

gataagcggt acaaattgtt agggttccag gccatgcctg atacatctga gtttttgctg     6420

gaggtaggaa atttcaactc agaagctcat ccacagaaaa cagtgaccag cagcaggtat     6480

ggagccataa ggctggaagg cttcaaagac cccttcttct gttactgtta tccacggcag     6540

ttattctgtg taggtgtgaa ggagtggcta ctgactctgt gtggatcagc gtttacatat     6600

gacctgatgg gagtgcatct ggtatgtgtt cctcccccct gtattgctgg agagattggc     6660

aatcgtaggt atacacggaa gtgtcgggat gttcagtggc gcgcacttgg atgtttcttt     6720

tcactttatt tctatagaaa caggttccag gagccagaga agtaggggaa aaaatccctg     6780

agctcatctc tctctactac ttaataatgc aaacatttaa attcttggga agattttccc     6840

gccccactcc ctacccccag tcacaggtca gaataggatt tccttcttag agaaggtagg     6900

tcatggggcc tgcgattaaa aaaacaaaaa cataaaacaa acaaacaaac aaggtggctt     6960

tccttggtct ttgtgattcc agctcttcac cagtgaagga attctttagt tccatagtgc     7020

agcctgggtg ggtggagaag aggctgttat agtgggagcc agtgagcaaa gagggttgga     7080

ggaggcagag gacagggctc agggaaggca agcctgtggc tctgggcatt ggccctcttg     7140

tcaaaggtgt cagagcatgg cttcctgtga ggggctttcc cttgctcctg tgtgagaatc     7200

tgtgcgttgt cttactggat gggggacctg gatggagatg ttaggggaga tagcttagtc     7260

ttgttctaaa ctctagactt gctaaaaagg gttctcttga gtccaaatgc agtgccagag     7320

ggtgagaagc agaattggcc agtagtgaac agtggtattg tgggtgataa gccctttctg     7380

gtggccttaa atagcagtgc tagtccttga gtgccacagg gtcccctacc tccgtcctgg     7440

cagtgctgat gggtttgttt cagcatattt tggttctcat tctcatttag ggaaaagggc     7500

tgttgatgaa gggattatcc tcccaggcac caggggcctc agcacagttc cctgtgcttt     7560

taaacactgt tgactttcat tagttattct aaagggattt atattggaga tacaactccc     7620

tttggtttca tattatgaaa tagctttgta ctgtggaatg ctaactctgg aaagtctccc     7680

tcataccaga accaaacatt catttctttt atatatatat atatattatc tccctggtac     7740

tctccaggga ggtggttatt atcaagctga cccaaaggag tgcagtatgt gttctagttc     7800

cttttctggt accttgttca acattctttt ttcctgaaga acatcctttt gtttatgaaa     7860

acgtgaatag catcatgtaa aacaatccct tgctatcaga atgctccagt ttggccttaa     7920

ttttgtaaac cttggagagg agtggagcgc ggctgtgaga agagatgtac catgtactct     7980

ttctgtatca ttaaagtgca gtttttatgc ttct                                 8014


<210>  46
<211>  770
<212>  PRT
<213>  Mus musculus

<400>  46

Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Val Pro Ser Thr Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Leu Ser Leu 
            100                 105                 110         


Phe Arg Asn Arg Leu Arg Leu Ser Lys Gly Leu Gln Val Asp Val Gly 
        115                 120                 125             


Ser Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Asn Gly Leu Glu Ser Asp Phe Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Pro Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Ser Thr Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Ser Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Asp Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Val 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Ser Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Gln Ser Lys Ser Lys 
        355                 360                 365             


Asn Pro Trp Tyr Ile Asp Glu Ala Phe Gly Gly Tyr Leu Ser Glu Val 
    370                 375                 380                 


Val Glu Glu Asn Thr Pro Pro Lys Met Glu Lys Glu Gly Leu Glu Ile 
385                 390                 395                 400 


Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr 
                405                 410                 415     


Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Ala Leu Asp 
            420                 425                 430         


Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Ile Glu Tyr Tyr Ser 
        435                 440                 445             


Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile 
    450                 455                 460                 


Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu 
465                 470                 475                 480 


Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro 
                485                 490                 495     


Glu Glu Phe Leu Asn Ile Leu Phe His Asp Ile Leu Arg Val Glu Pro 
            500                 505                 510         


Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Asn Phe 
        515                 520                 525             


Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile 
    530                 535                 540                 


Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala 
545                 550                 555                 560 


Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp 
                565                 570                 575     


Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr 
            580                 585                 590         


Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu 
        595                 600                 605             


Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala 
    610                 615                 620                 


Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Ser Thr Gln Val His Leu 
625                 630                 635                 640 


His Pro Arg Arg Leu Asn His Ser Tyr His Pro Val Ser Leu Pro Lys 
                645                 650                 655     


Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Lys 
            660                 665                 670         


Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala 
        675                 680                 685             


Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser 
    690                 695                 700                 


Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val 
705                 710                 715                 720 


Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp 
                725                 730                 735     


Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu 
            740                 745                 750         


Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro Thr Met Ser Leu 
        755                 760                 765             


Tyr Lys 
    770 


<210>  47
<211>  7599
<212>  DNA
<213>  Mus musculus

<400>  47
agttcggagg cggggcaggt gggggcgggc ccaggtagca ggttcggctg cgcgggggcc       60

cgcgcgcctg agtgagctcc tatgtcatgg attctgaact ggcttataat atctggcatg      120

gattcctttt agcagagcag gcctcaaatc cgatagagca tggttgcttg atcccattgc      180

agccctgcca ctagtggctc ctggcacttt gaattgctgt ctttttacaa catggatgcc      240

aggttgctaa aatcttgctt tgggacttac agcgagttca tttttttgga ttttatgaca      300

gatttactag tggctccttt ttgccagtca atgttctgaa agttactgtc acaatgagtt      360

caggcctgtg gagccaagag aaagttactt caccctactg ggaagaacgg attttttatc      420

tgcttcttca agaatgcagt gtaacagaca aacaaactca gaagctgctg aaagtaccca      480

aagggagtat aggacagtac atccaagacc gttctgtggg gcattcaaga gttccttcca      540

caaaaggcaa gaaaaatcag attggattaa aaatcttgga gcaaccgcat gcagttctgt      600

ttgttgatga aaaggatgtt gtagaaataa atgaaaaatt cacagagtta ctgttggcaa      660

ttaccaactg tgaggagagg ctcagcctat ttagaaacag actccgacta agtaaaggcc      720

tccaggtaga cgtgggcagt cctgtgaaag tacagctgcg atctggggaa gagaaatttc      780

caggagttgt acgcttcaga ggacctttat tagcggagag gacggtgtcg gggattttct      840

ttggagtaga attattggaa gaaggtcgtg gtcaaggttt cacggatggg gtatatcaag      900

ggaagcagct tttccagtgt gatgaggact gtggcgtgtt tgttgcattg gacaaactag      960

aacttataga agatgatgac aatggattgg aaagtgattt tgcaggccca ggagatacaa     1020

tgcaggttga acctccccct ttggaaataa actccagagt ttctttgaag gttggagaaa     1080

gtacagaatc tggaacagta atattctgtg atgttttacc aggaaaagag agtctaggat     1140

attttgttgg tgtggacatg gataacccta ttggcaactg ggatggaagg tttgatggag     1200

tacagctctg tagttttgca agtgttgaaa gtacaattct cctgcacatc aatgacatca     1260

tcccagatag cgtgacacag gaaaggaggc ctcccaaact tgcctttatg tcaagaggtg     1320

taggtgacaa aggttcatct agtcataata aaccaaaggt tacaggatct acctcagacc     1380

ctggaagtag aaacagatct gaattatttt ataccttaaa tgggtcatct gttgactcac     1440

aacaatccaa gtccaaaaat ccatggtaca ttgatgaagc atttgggggc tatttaagtg     1500

aagtagtaga agaaaatact ccacctaaaa tggaaaagga aggtttagag ataatgattg     1560

gaaagaagaa aggcatccag ggccattaca attcttgtta cttagactca actttattct     1620

gcttatttgc ttttagttct gccctggaca ctgtgttact tagacccaaa gagaagaatg     1680

atatagagta ttacagtgag actcaggagc tactgaggac agagatagtc aatcctctga     1740

gaatatatgg atatgtgtgt gccacaaaga ttatgaaact gaggaaaata cttgaaaaag     1800

ttgaggctgc atcaggtttt acctctgaag aaaaagatcc tgaagaattc ttaaatatcc     1860

tgtttcatga tattttaagg gttgaaccat tgttaaaaat aagatcagca ggtcaaaaag     1920

ttcaagactg taacttctat caaattttta tggaaaaaaa tgagaaagtt ggagtaccca     1980

caattcagca gttattagaa tggtctttta tcaacagcaa cctgaaattt gcagaggcac     2040

catcatgctt gattatccag atgcctcggt ttggaaaaga ctttaaacta tttaaaaaaa     2100

tttttccttc cctggaatta aatataacag atttacttga agacactccc aggcagtgcc     2160

gcatctgtgg aggacttgcg atgtacgagt gcagggagtg ctatgacgat ccggacatct     2220

cagctgggaa gatcaagcag ttctgtaaga cctgcagcac tcaggttcac cttcatccca     2280

ggaggttgaa tcattcttat catccagtat cacttcccaa agacttgcct gactgggact     2340

ggagacacgg ctgcatcccc tgtcagaaga tggagttatt tgctgttctc tgcatagaaa     2400

cgagccacta tgttgctttt gtgaagtatg ggaaggatga ctctgcctgg cttttctttg     2460

acagcatggc ggatcgagat ggtggtcaga atggcttcaa cattccacaa gtgacgccct     2520

gcccagaagt gggagagtac ttgaagatgt ctctggagga cctgcactct ttggattcca     2580

gaaggattca aggctgtgcg cgcagacttc tttgcgatgc atacatgtgc atgtaccaga     2640

gtccaaccat gagcctgtac aaataaccag gttatccgca gtgggcagag acagcacaaa     2700

ccttagtgct gtgtcttcct ccagcttgtg gttctgtccg gcacccattg ccggcaatgg     2760

gtgtctcttt tgatgatggc ccttcagcaa aggattcctg tgtttccaaa caaattgctt     2820

ttgtgttcct gaagtattta ataagaagca ttttgcactc taggaagtat gtttgtgttg     2880

attttttaag aagtctaaat ggatttatta atatctgaca ctttaagtta actgcattga     2940

tgatacgata tttttggaag catacaattt taattgtgac gtctaaaacc tcttttagtc     3000

cattgaggat gtaaataaat atttcttctt atggaccagg gatatgaaat cattttcctt     3060

ttgtagctaa tgattgcctt gagaaagaca taatatgatt ttattaagag tctgccttta     3120

ctccaattgt tgaaggtgtg ctgagtttaa ttgttaattt tcctatatag tgctgatttc     3180

ctgcatgtct gtactttgct gagtttctgt gttcctgcag cagtggtcag aacatgctga     3240

aattcctttc atggtgttat tttttatttg ttctagtttt gagataaatg agtgactctg     3300

tcataaaatg tccatttttg atttgttctt gaagaattag ggtacaaaac aagtatcgta     3360

gtcatagtaa caactgttac tgaacaggtc ttctgtaggg gctcctaagt atgagacaac     3420

atgcagtggt ttctgaaatg actgagcgat aagtaaatta tatattcttt ttttaaaaga     3480

tttattttat ttatatgagt acactgtagc tgtcttcaga cacaccagaa gagggcatca     3540

gatcttatta cagatggttg tgagccacca tgtggttgct gggaattgaa ctcaggacct     3600

ttggaagggc agtcagtgct cttaactgct gagctatctc tctagcccca aattatatat     3660

tcttatacag acccacagtc cagagaaagt gaagctggct cagagttagc accaacattt     3720

ccctgaaaaa atgtgttagg tgtttaaaaa tctcatcgta aataaattat tttattttta     3780

gtttaagtga atttctctta atttaaataa gactaatatt tttgtttgac tgaagaccct     3840

tgtactctct ggtgtcagtt tggtgtcact tgaaacaatg acaaccacgt cagcatgtta     3900

ctgcaatgtc agtgatggtt tcaaaggaga aaatggatgt catcttagga ctgcttgtgt     3960

gtgtatagac cgtggtggat gctgtagagt gcttgttgtc tgagtgttgt tttgtggtat     4020

ggctgtctct ctgaataatg tcaaccttac agaaagagaa ggtgttatat gtgtaacata     4080

tggctttata aaagatttaa tgtcaaaaga gtctataaat attgctgtta tttttaaagg     4140

cactttactc cttggtttta ttattccatt ttgctggcgt gtattagctt tatataaatc     4200

acaacacaca aaactcgtcc atcttgtaat ctttgtactt ttgcaatgga aaagtgtgta     4260

tactgtgcac agacttttat atagctgagt gcctagactg ggtggagagg ccatgagtag     4320

atagcagtaa agtcctccag ctataggcta gccttgtctt catcatcctg ggacaggtga     4380

gaacggtgag cacaggtgag tctgagcttg cacactgacc agaattcagt caccctgtaa     4440

taagtatgta tttaatgagt ctgttagtgt ggtagtgtga ttttgaaagg tttaactaag     4500

gaatggtgag gtctttgttt ataggcaagc ctggcttaac agtgaagggg agggggctga     4560

gggaaagctt tttttttttt taatttcaga aatggaagca aaatccatgt gcaaagagac     4620

tagctacttg gctttcagag cagaggactc aaagcttgtt tgcagtggtt ctgaagttgg     4680

ggtggcactt tgtgagtgag gaggaccatg tccacaggca atccctaagc aagatcgtct     4740

cgaaattgca ctgtgttctt tagcagtagt ggctgggtag gggcacacag cggaacaccc     4800

acttgcagtg gctggggagg cctgagaagc acaggccagc gggagctctc tcccatgcct     4860

tcttgtccct ctggacagcc cctcctcatt ccttgtccca gcagagcctg gtttgcccct     4920

ggggcaatag ggttggactg tgtggtgcag atagccctcg tgcctgtgga ttactttaat     4980

tttgtaatct taggttttct gtacggtttt cccattgcct tttaaaatat tttgagtgtc     5040

cttctcctta tcaagatggt agtgtagtag gattgtttta ctcacaacat ggtttaggag     5100

ccatagctac aaataggaaa tataagaatt ctatttctct actgtgaggc aaatctgtat     5160

atatgtatgg agagtcagga ggatgaacaa gggagaggaa aggggcccag gcacattttt     5220

aatccaaaag ctacaaagtg tcgagctcct cagggccagc ttcacagaga gtccagctca     5280

gttcacaaag tattttctaa gttggggaaa tgcattgaga aacagagcga gatatctgtg     5340

tagtgcagct gtgggtggtt gctatgcatt ttatcctcag agtagcctgg ggtttttatt     5400

ttatgtttgc caagtgctta ggtaaatggc cgggctcctc ttacctctga cttctggagc     5460

gtgtccattc tctggttgac tgaatgtggc attttcataa atctaggagc agcagccctc     5520

ccaactgcaa tttagtaagc aggtagataa gcttgcatct gtttgcatct tcctgcactg     5580

agttgggagt gcaaaacccc gtacttggcc tggtgagtaa ctgccaacaa gtatttatgg     5640

gtcatttgct aggtggctag catacggcac ggggctaatg agacctgggg cctgctctca     5700

tatagcttac tgctcagttt ctataccaga gcatccgttg gtgcttctta gcctaggcat     5760

gggtgacagg catgtctggg gaccactttg ggagacaacc tagtgtaacc ttattgcaaa     5820

ggactaagag acaaaaatcc tgggttcttt ctccatcact tgctctgtag ctgaatgaac     5880

accacctcga tttcttgagt ttcagtgtct tgttctgtct gatgaaaggg ttggatatgt     5940

agttggataa gcggtacaaa ttgttagggt tccaggccat gcctgataca tctgagtttt     6000

tgctggaggt aggaaatttc aactcagaag ctcatccaca gaaaacagtg accagcagca     6060

ggtatggagc cataaggctg gaaggcttca aagacccctt cttctgttac tgttatccac     6120

ggcagttatt ctgtgtaggt gtgaaggagt ggctactgac tctgtgtgga tcagcgttta     6180

catatgacct gatgggagtg catctggtat gtgttcctcc cccctgtatt gctggagaga     6240

ttggcaatcg taggtataca cggaagtgtc gggatgttca gtggcgcgca cttggatgtt     6300

tcttttcact ttatttctat agaaacaggt tccaggagcc agagaagtag gggaaaaaat     6360

ccctgagctc atctctctct actacttaat aatgcaaaca tttaaattct tgggaagatt     6420

ttcccgcccc actccctacc cccagtcaca ggtcagaata ggatttcctt cttagagaag     6480

gtaggtcatg gggcctgcga ttaaaaaaac aaaaacataa aacaaacaaa caaacaaggt     6540

ggctttcctt ggtctttgtg attccagctc ttcaccagtg aaggaattct ttagttccat     6600

agtgcagcct gggtgggtgg agaagaggct gttatagtgg gagccagtga gcaaagaggg     6660

ttggaggagg cagaggacag ggctcaggga aggcaagcct gtggctctgg gcattggccc     6720

tcttgtcaaa ggtgtcagag catggcttcc tgtgaggggc tttcccttgc tcctgtgtga     6780

gaatctgtgc gttgtcttac tggatggggg acctggatgg agatgttagg ggagatagct     6840

tagtcttgtt ctaaactcta gacttgctaa aaagggttct cttgagtcca aatgcagtgc     6900

cagagggtga gaagcagaat tggccagtag tgaacagtgg tattgtgggt gataagccct     6960

ttctggtggc cttaaatagc agtgctagtc cttgagtgcc acagggtccc ctacctccgt     7020

cctggcagtg ctgatgggtt tgtttcagca tattttggtt ctcattctca tttagggaaa     7080

agggctgttg atgaagggat tatcctccca ggcaccaggg gcctcagcac agttccctgt     7140

gcttttaaac actgttgact ttcattagtt attctaaagg gatttatatt ggagatacaa     7200

ctccctttgg tttcatatta tgaaatagct ttgtactgtg gaatgctaac tctggaaagt     7260

ctccctcata ccagaaccaa acattcattt cttttatata tatatatata ttatctccct     7320

ggtactctcc agggaggtgg ttattatcaa gctgacccaa aggagtgcag tatgtgttct     7380

agttcctttt ctggtacctt gttcaacatt cttttttcct gaagaacatc cttttgttta     7440

tgaaaacgtg aatagcatca tgtaaaacaa tcccttgcta tcagaatgct ccagtttggc     7500

cttaattttg taaaccttgg agaggagtgg agcgcggctg tgagaagaga tgtaccatgt     7560

actctttctg tatcattaaa gtgcagtttt tatgcttct                            7599


<210>  48
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  49
<211>  10667
<212>  DNA
<213>  Homo sapiens

<400>  49
agcgccccct ccgagatccc ggggagccag cttgctggga gagcgggacg gtccggagca       60

agcccagagg cagaggaggc gacagaggga aaaagggccg agctagccgc tccagtgctg      120

tacaggagcc gaagggacgc accacgccag ccccagcccg gctccagcga cagccaacgc      180

ctcttgcagc gcggcggctt cgaagccgcc gcccggagct gccctttcct cttcggtgaa      240

gtttttaaaa gctgctaaag actcggagga agcaaggaaa gtgcctggta ggactgacgg      300

ctgcctttgt cctcctcctc tccaccccgc ctccccccac cctgccttcc ccccctcccc      360

cgtcttctct cccgcagctg cctcagtcgg ctactctcag ccaacccccc tcaccaccct      420

tctccccacc cgcccccccg cccccgtcgg cccagcgctg ccagcccgag tttgcagaga      480

ggtaactccc tttggctgcg agcgggcgag ctagctgcac attgcaaaga aggctcttag      540

gagccaggcg actggggagc ggcttcagca ctgcagccac gacccgcctg gttaggctgc      600

acgcggagag aaccctctgt tttcccccac tctctctcca cctcctcctg ccttccccac      660

cccgagtgcg gagccagaga tcaaaagatg aaaaggcagt caggtcttca gtagccaaaa      720

aacaaaacaa acaaaaacaa aaaagccgaa ataaaagaaa aagataataa ctcagttctt      780

atttgcacct acttcagtgg acactgaatt tggaaggtgg aggattttgt ttttttcttt      840

taagatctgg gcatcttttg aatctaccct tcaagtatta agagacagac tgtgagccta      900

gcagggcaga tcttgtccac cgtgtgtctt cttctgcacg agactttgag gctgtcagag      960

cgctttttgc gtggttgctc ccgcaagttt ccttctctgg agcttcccgc aggtgggcag     1020

ctagctgcag cgactaccgc atcatcacag cctgttgaac tcttctgagc aagagaaggg     1080

gaggcggggt aagggaagta ggtggaagat tcagccaagc tcaaggatgg aagtgcagtt     1140

agggctggga agggtctacc ctcggccgcc gtccaagacc taccgaggag ctttccagaa     1200

tctgttccag agcgtgcgcg aagtgatcca gaacccgggc cccaggcacc cagaggccgc     1260

gagcgcagca cctcccggcg ccagtttgct gctgctgcag cagcagcagc agcagcagca     1320

gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcaagaga ctagccccag     1380

gcagcagcag cagcagcagg gtgaggatgg ttctccccaa gcccatcgta gaggccccac     1440

aggctacctg gtcctggatg aggaacagca accttcacag ccgcagtcgg ccctggagtg     1500

ccaccccgag agaggttgcg tcccagagcc tggagccgcc gtggccgcca gcaaggggct     1560

gccgcagcag ctgccagcac ctccggacga ggatgactca gctgccccat ccacgttgtc     1620

cctgctgggc cccactttcc ccggcttaag cagctgctcc gctgacctta aagacatcct     1680

gagcgaggcc agcaccatgc aactccttca gcaacagcag caggaagcag tatccgaagg     1740

cagcagcagc gggagagcga gggaggcctc gggggctccc acttcctcca aggacaatta     1800

cttagggggc acttcgacca tttctgacaa cgccaaggag ttgtgtaagg cagtgtcggt     1860

gtccatgggc ctgggtgtgg aggcgttgga gcatctgagt ccaggggaac agcttcgggg     1920

ggattgcatg tacgccccac ttttgggagt tccacccgct gtgcgtccca ctccttgtgc     1980

cccattggcc gaatgcaaag gttctctgct agacgacagc gcaggcaaga gcactgaaga     2040

tactgctgag tattcccctt tcaagggagg ttacaccaaa gggctagaag gcgagagcct     2100

aggctgctct ggcagcgctg cagcagggag ctccgggaca cttgaactgc cgtctaccct     2160

gtctctctac aagtccggag cactggacga ggcagctgcg taccagagtc gcgactacta     2220

caactttcca ctggctctgg ccggaccgcc gccccctccg ccgcctcccc atccccacgc     2280

tcgcatcaag ctggagaacc cgctggacta cggcagcgcc tgggcggctg cggcggcgca     2340

gtgccgctat ggggacctgg cgagcctgca tggcgcgggt gcagcgggac ccggttctgg     2400

gtcaccctca gccgccgctt cctcatcctg gcacactctc ttcacagccg aagaaggcca     2460

gttgtatgga ccgtgtggtg gtggtggggg tggtggcggc ggcggcggcg gcggcggcgg     2520

cggcggcggc ggcggcggcg gcggcgaggc gggagctgta gccccctacg gctacactcg     2580

gccccctcag gggctggcgg gccaggaaag cgacttcacc gcacctgatg tgtggtaccc     2640

tggcggcatg gtgagcagag tgccctatcc cagtcccact tgtgtcaaaa gcgaaatggg     2700

cccctggatg gatagctact ccggacctta cggggacatg cgtttggaga ctgccaggga     2760

ccatgttttg cccattgact attactttcc accccagaag acctgcctga tctgtggaga     2820

tgaagcttct gggtgtcact atggagctct cacatgtgga agctgcaagg tcttcttcaa     2880

aagagccgct gaagggaaac agaagtacct gtgcgccagc agaaatgatt gcactattga     2940

taaattccga aggaaaaatt gtccatcttg tcgtcttcgg aaatgttatg aagcagggat     3000

gactctggga gcccggaagc tgaagaaact tggtaatctg aaactacagg aggaaggaga     3060

ggcttccagc accaccagcc ccactgagga gacaacccag aagctgacag tgtcacacat     3120

tgaaggctat gaatgtcagc ccatctttct gaatgtcctg gaagccattg agccaggtgt     3180

agtgtgtgct ggacacgaca acaaccagcc cgactccttt gcagccttgc tctctagcct     3240

caatgaactg ggagagagac agcttgtaca cgtggtcaag tgggccaagg ccttgcctgg     3300

cttccgcaac ttacacgtgg acgaccagat ggctgtcatt cagtactcct ggatggggct     3360

catggtgttt gccatgggct ggcgatcctt caccaatgtc aactccagga tgctctactt     3420

cgcccctgat ctggttttca atgagtaccg catgcacaag tcccggatgt acagccagtg     3480

tgtccgaatg aggcacctct ctcaagagtt tggatggctc caaatcaccc cccaggaatt     3540

cctgtgcatg aaagcactgc tactcttcag cattattcca gtggatgggc tgaaaaatca     3600

aaaattcttt gatgaacttc gaatgaacta catcaaggaa ctcgatcgta tcattgcatg     3660

caaaagaaaa aatcccacat cctgctcaag acgcttctac cagctcacca agctcctgga     3720

ctccgtgcag cctattgcga gagagctgca tcagttcact tttgacctgc taatcaagtc     3780

acacatggtg agcgtggact ttccggaaat gatggcagag atcatctctg tgcaagtgcc     3840

caagatcctt tctgggaaag tcaagcccat ctatttccac acccagtgaa gcattggaaa     3900

ccctatttcc ccaccccagc tcatgccccc tttcagatgt cttctgcctg ttataactct     3960

gcactactcc tctgcagtgc cttggggaat ttcctctatt gatgtacagt ctgtcatgaa     4020

catgttcctg aattctattt gctgggcttt ttttttctct ttctctcctt tctttttctt     4080

cttccctccc tatctaaccc tcccatggca ccttcagact ttgcttccca ttgtggctcc     4140

tatctgtgtt ttgaatggtg ttgtatgcct ttaaatctgt gatgatcctc atatggccca     4200

gtgtcaagtt gtgcttgttt acagcactac tctgtgccag ccacacaaac gtttacttat     4260

cttatgccac gggaagttta gagagctaag attatctggg gaaatcaaaa caaaaacaag     4320

caaacaaaaa aaaaaagcaa aaacaaaaca aaaaataagc caaaaaacct tgctagtgtt     4380

ttttcctcaa aaataaataa ataaataaat aaatacgtac atacatacac acatacatac     4440

aaacatatag aaatccccaa agaggccaat agtgacgaga aggtgaaaat tgcaggccca     4500

tggggagtta ctgatttttt catctcctcc ctccacggga gactttattt tctgccaatg     4560

gctattgcca ttagagggca gagtgacccc agagctgagt tgggcagggg ggtggacaga     4620

gaggagagga caaggagggc aatggagcat cagtacctgc ccacagcctt ggtccctggg     4680

ggctagactg ctcaactgtg gagcaattca ttatactgaa aatgtgcttg ttgttgaaaa     4740

tttgtctgca tgttaatgcc tcacccccaa acccttttct ctctcactct ctgcctccaa     4800

cttcagattg actttcaata gtttttctaa gacctttgaa ctgaatgttc tcttcagcca     4860

aaacttggcg acttccacag aaaagtctga ccactgagaa gaaggagagc agagatttaa     4920

ccctttgtaa ggccccattt ggatccaggt ctgctttctc atgtgtgagt cagggaggag     4980

ctggagccag aggagaagaa aatgatagct tggctgttct cctgcttagg acactgactg     5040

aatagttaaa ctctcactgc cactaccttt tccccacctt taaaagacct gaatgaagtt     5100

ttctgccaaa ctccgtgaag ccacaagcac cttatgtcct cccttcagtg ttttgtgggc     5160

ctgaatttca tcacactgca tttcagccat ggtcatcaag cctgtttgct tcttttgggc     5220

atgttcacag attctctgtt aagagccccc accaccaaga aggttagcag gccaacagct     5280

ctgacatcta tctgtagatg ccagtagtca caaagatttc ttaccaactc tcagatcgct     5340

ggagccctta gacaaactgg aaagaaggca tcaaagggat caggcaagct gggcgtcttg     5400

cccttgtccc ccagagatga taccctccca gcaagtggag aagttctcac ttccttcttt     5460

agagcagcta aaggggctac ccagatcagg gttgaagaga aaactcaatt accagggtgg     5520

gaagaatgaa ggcactagaa ccagaaaccc tgcaaatgct cttcttgtca cccagcatat     5580

ccacctgcag aagtcatgag aagagagaag gaacaaagag gagactctga ctactgaatt     5640

aaaatcttca gcggcaaagc ctaaagccag atggacacca tctggtgagt ttactcatca     5700

tcctcctctg ctgctgattc tgggctctga cattgcccat actcactcag attccccacc     5760

tttgttgctg cctcttagtc agagggaggc caaaccattg agactttcta cagaaccatg     5820

gcttctttcg gaaaggtctg gttggtgtgg ctccaatact ttgccaccca tgaactcagg     5880

gtgtgccctg ggacactggt tttatatagt cttttggcac acctgtgttc tgttgacttc     5940

gttcttcaag cccaagtgca agggaaaatg tccacctact ttctcatctt ggcctctgcc     6000

tccttactta gctcttaatc tcatctgttg aactcaagaa atcaagggcc agtcatcaag     6060

ctgcccattt taattgattc actctgtttg ttgagaggat agtttctgag tgacatgata     6120

tgatccacaa gggtttcctt ccctgatttc tgcattgata ttaatagcca aacgaacttc     6180

aaaacagctt taaataacaa gggagagggg aacctaagat gagtaatatg ccaatccaag     6240

actgctggag aaaactaaag ctgacaggtt ccctttttgg ggtgggatag acatgttctg     6300

gttttcttta ttattacaca atctggctca tgtacaggat cacttttagc tgttttaaac     6360

agaaaaaaat atccaccact cttttcagtt acactaggtt acattttaat aggtccttta     6420

catctgtttt ggaatgattt tcatcttttg tgatacacag attgaattat atcattttca     6480

tatctctcct tgtaaatact agaagctctc ctttacattt ctctatcaaa tttttcatct     6540

ttatgggttt cccaattgtg actcttgtct tcatgaatat atgtttttca tttgcaaaag     6600

ccaaaaatca gtgaaacagc agtgtaatta aaagcaacaa ctggattact ccaaatttcc     6660

aaatgacaaa actagggaaa aatagcctac acaagccttt aggcctactc tttctgtgct     6720

tgggtttgag tgaacaaagg agattttagc ttggctctgt tctcccatgg atgaaaggag     6780

gaggattttt tttttctttt ggccattgat gttctagcca atgtaattga cagaagtctc     6840

attttgcatg cgctctgctc tacaaacaga gttggtatgg ttggtatact gtactcacct     6900

gtgagggact ggccactcag acccacttag ctggtgagct agaagatgag gatcactcac     6960

tggaaaagtc acaaggacca tctccaaaca agttggcagt gctcgatgtg gacgaagagt     7020

gaggaagaga aaaagaagga gcaccaggga gaaggctccg tctgtgctgg gcagcagaca     7080

gctgccagga tcacgaactc tgtagtcaaa gaaaagagtc gtgtggcagt ttcagctctc     7140

gttcattggg cagctcgcct aggcccagcc tctgagctga catgggagtt gttggattct     7200

ttgtttcata gctttttcta tgccataggc aatattgttg ttcttggaaa gtttattatt     7260

tttttaactc ccttactctg agaaagggat attttgaagg actgtcatat atctttgaaa     7320

aaagaaaatc tgtaatacat atatttttat gtatgttcac tggcactaaa aaatatagag     7380

agcttcattc tgtcctttgg gtagttgctg aggtaattgt ccaggttgaa aaataatgtg     7440

ctgatgctag agtccctctc tgtccatact ctacttctaa atacatatag gcatacatag     7500

caagttttat ttgacttgta ctttaagaga aaatatgtcc accatccaca tgatgcacaa     7560

atgagctaac attgagcttc aagtagcttc taagtgtttg tttcattagg cacagcacag     7620

atgtggcctt tccccccttc tctcccttga tatctggcag ggcataaagg cccaggccac     7680

ttcctctgcc ccttcccagc cctgcaccaa agctgcattt caggagactc tctccagaca     7740

gcccagtaac tacccgagca tggcccctgc atagccctgg aaaaataaga ggctgactgt     7800

ctacgaatta tcttgtgcca gttgcccagg tgagagggca ctgggccaag ggagtggttt     7860

tcatgtttga cccactacaa ggggtcatgg gaatcaggaa tgccaaagca ccagatcaaa     7920

tccaaaactt aaagtcaaaa taagccattc agcatgttca gtttcttgga aaaggaagtt     7980

tctacccctg atgcctttgt aggcagatct gttctcacca ttaatctttt tgaaaatctt     8040

ttaaagcagt ttttaaaaag agagatgaaa gcatcacatt atataaccaa agattacatt     8100

gtacctgcta agataccaaa attcataagg gcaggggggg agcaagcatt agtgcctctt     8160

tgataagctg tccaaagaca gactaaagga ctctgctggt gactgactta taagagcttt     8220

gtgggttttt ttttccctaa taatatacat gtttagaaga attgaaaata atttcgggaa     8280

aatgggatta tgggtccttc actaagtgat tttataagca gaactggctt tccttttctc     8340

tagtagttgc tgagcaaatt gttgaagctc catcattgca tggttggaaa tggagctgtt     8400

cttagccact gtgtttgcta gtgcccatgt tagcttatct gaagatgtga aacccttgct     8460

gataagggag catttaaagt actagatttt gcactagagg gacagcaggc agaaatcctt     8520

atttctgccc actttggatg gcacaaaaag ttatctgcag ttgaaggcag aaagttgaaa     8580

tacattgtaa atgaatattt gtatccatgt ttcaaaattg aaatatatat atatatatat     8640

atatatatat atatatatat atagtgtgtg tgtgtgttct gatagcttta actttctctg     8700

catctttata tttggttcca gatcacacct gatgccatgt acttgtgaga gaggatgcag     8760

ttttgttttg gaagctctct cagaacaaac aagacacctg gattgatcag ttaactaaaa     8820

gttttctccc ctattgggtt tgacccacag gtcctgtgaa ggagcagagg gataaaaaga     8880

gtagaggaca tgatacattg tactttacta gttcaagaca gatgaatgtg gaaagcataa     8940

aaactcaatg gaactgactg agatttacca cagggaaggc ccaaacttgg ggccaaaagc     9000

ctacccaagt gattgaccag tggcccccta atgggacctg agctgttgga agaagagaac     9060

tgttccttgg tcttcaccat ccttgtgaga gaagggcagt ttcctgcatt ggaacctgga     9120

gcaagcgctc tatctttcac acaaattccc tcacctgaga ttgaggtgct cttgttactg     9180

ggtgtctgtg tgctgtaatt ctggttttgg atatgttctg taaagatttt gacaaatgaa     9240

aatgtgtttt tctctgttaa aacttgtcag agtactagaa gttgtatctc tgtaggtgca     9300

ggtccatttc tgcccacagg tagggtgttt ttctttgatt aagagattga cacttctgtt     9360

gcctaggacc tcccaactca accatttcta ggtgaaggca gaaaaatcca cattagttac     9420

tcctcttcag acatttcagc tgagataaca aatcttttgg aattttttca cccatagaaa     9480

gagtggtaga tatttgaatt tagcaggtgg agtttcatag taaaaacagc ttttgactca     9540

gctttgattt atcctcattt gatttggcca gaaagtaggt aatatgcatt gattggcttc     9600

tgattccaat tcagtatagc aaggtgctag gttttttcct ttccccacct gtctcttagc     9660

ctggggaatt aaatgagaag ccttagaatg ggtggccctt gtgacctgaa acacttccca     9720

cataagctac ttaacaagat tgtcatggag ctgcagattc cattgcccac caaagactag     9780

aacacacaca tatccataca ccaaaggaaa gacaattctg aaatgctgtt tctctggtgg     9840

ttccctctct ggctgctgcc tcacagtatg ggaacctgta ctctgcagag gtgacaggcc     9900

agatttgcat tatctcacaa ccttagccct tggtgctaac tgtcctacag tgaagtgcct     9960

ggggggttgt cctatcccat aagccacttg gatgctgaca gcagccacca tcagaatgac    10020

ccacgcaaaa aaaagaaaaa aaaaattaaa aagtcccctc acaacccagt gacacctttc    10080

tgctttcctc tagactggaa cattgattag ggagtgcctc agacatgaca ttcttgtgct    10140

gtccttggaa ttaatctggc agcaggaggg agcagactat gtaaacagag ataaaaatta    10200

attttcaata ttgaaggaaa aaagaaataa gaagagagag agaaagaaag catcacacaa    10260

agattttctt aaaagaaaca attttgcttg aaatctcttt agatggggct catttctcac    10320

ggtggcactt ggcctccact gggcagcagg accagctcca agcgctagtg ttctgttctc    10380

tttttgtaat cttggaatct tttgttgctc taaatacaat taaaaatggc agaaacttgt    10440

ttgttggact acatgtgtga ctttgggtct gtctctgcct ctgctttcag aaatgtcatc    10500

cattgtgtaa aatattggct tactggtctg ccagctaaaa cttggccaca tcccctgtta    10560

tggctgcagg atcgagttat tgttaacaaa gagacccaag aaaagctgct aatgtcctct    10620

tatcattgtt gttaatttgt taaaacataa agaaatctaa aatttca                  10667


<210>  50
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ile Leu Trp Leu His Ser Leu Glu Thr Ala Arg Asp His Val Leu 
1               5                   10                  15      


Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly 
            20                  25                  30          


Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys 
        35                  40                  45              


Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys 
    50                  55                  60                  


Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys 
65                  70                  75                  80  


Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly 
                85                  90                  95      


Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly 
            100                 105                 110         


Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr Gln Lys Leu 
        115                 120                 125             


Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn 
    130                 135                 140                 


Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn 
145                 150                 155                 160 


Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu 
                165                 170                 175     


Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro 
            180                 185                 190         


Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr 
        195                 200                 205             


Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr 
    210                 215                 220                 


Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn 
225                 230                 235                 240 


Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met 
                245                 250                 255     


Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu 
            260                 265                 270         


Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp 
        275                 280                 285             


Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile 
    290                 295                 300                 


Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser 
305                 310                 315                 320 


Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln 
                325                 330                 335     


Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys 
            340                 345                 350         


Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile 
        355                 360                 365             


Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr 
    370                 375                 380                 


Phe His Thr Gln 
385             


<210>  51
<211>  10257
<212>  DNA
<213>  Homo sapiens

<400>  51
gcggagagaa ccctctgttt tcccccactc tctctccacc tcctcctgcc ttccccaccc       60

cgagtgcgga gccagagatc aaaagatgaa aaggcagtca ggtcttcagt agccaaaaaa      120

caaaacaaac aaaaacaaaa aagccgaaat aaaagaaaaa gataataact cagttcttat      180

ttgcacctac ttcagtggac actgaatttg gaaggtggag gattttgttt ttttctttta      240

agatctgggc atcttttgaa tctacccttc aagtattaag agacagactg tgagcctagc      300

agggcagatc ttgtccaccg tgtgtcttct tctgcacgag actttgaggc tgtcagagcg      360

ctttttgcgt ggttgctccc gcaagtttcc ttctctggag cttcccgcag gtgggcagct      420

agctgcagcg actaccgcat catcacagcc tgttgaactc ttctgagcaa gagaagggga      480

ggcggggtaa gggaagtagg tggaagattc agccaagctc aaggatggaa gtgcagttag      540

ggctgggaag ggtctaccct cggccgccgt ccaagaccta ccgaggagct ttccagaatc      600

tgttccagag cgtgcgcgaa gtgatccaga acccgggccc caggcaccca gaggccgcga      660

gcgcagcacc tcccggcgcc agtttgctgc tgctgcagca gcagcagcag cagcagcagc      720

agcagcagca gcagcagcag cagcagcagc agcagcagca gcaagagact agccccaggc      780

agcagcagca gcagcagggt gaggatggtt ctccccaagc ccatcgtaga ggccccacag      840

gctacctggt cctggatgag gaacagcaac cttcacagcc gcagtcggcc ctggagtgcc      900

accccgagag aggttgcgtc ccagagcctg gagccgccgt ggccgccagc aaggggctgc      960

cgcagcagct gccagcacct ccggacgagg atgactcagc tgccccatcc acgttgtccc     1020

tgctgggccc cactttcccc ggcttaagca gctgctccgc tgaccttaaa gacatcctga     1080

gcgaggccag caccatgcaa ctccttcagc aacagcagca ggaagcagta tccgaaggca     1140

gcagcagcgg gagagcgagg gaggcctcgg gggctcccac ttcctccaag gacaattact     1200

tagggggcac ttcgaccatt tctgacaacg ccaaggagtt gtgtaaggca gtgtcggtgt     1260

ccatgggcct gggtgtggag gcgttggagc atctgagtcc aggggaacag cttcgggggg     1320

attgcatgta cgccccactt ttgggagttc cacccgctgt gcgtcccact ccttgtgccc     1380

cattggccga atgcaaaggt tctctgctag acgacagcgc aggcaagagc actgaagata     1440

ctgctgagta ttcccctttc aagggaggtt acaccaaagg gctagaaggc gagagcctag     1500

gctgctctgg cagcgctgca gcagggagct ccgggacact tgaactgccg tctaccctgt     1560

ctctctacaa gtccggagca ctggacgagg cagctgcgta ccagagtcgc gactactaca     1620

actttccact ggctctggcc ggaccgccgc cccctccgcc gcctccccat ccccacgctc     1680

gcatcaagct ggagaacccg ctggactacg gcagcgcctg ggcggctgcg gcggcgcagt     1740

gccgctatgg ggacctggcg agcctgcatg gcgcgggtgc agcgggaccc ggttctgggt     1800

caccctcagc cgccgcttcc tcatcctggc acactctctt cacagccgaa gaaggccagt     1860

tgtatggacc gtgtggtggt ggtgggggtg gtggcggcgg cggcggcggc ggcggcggcg     1920

gcggcggcgg cggcggcggc ggcgaggcgg gagctgtagc cccctacggc tacactcggc     1980

cccctcaggg gctggcgggc caggaaagcg acttcaccgc acctgatgtg tggtaccctg     2040

gcggcatggt gagcagagtg ccctatccca gtcccacttg tgtcaaaagc gaaatgggcc     2100

cctggatgga tagctactcc ggaccttacg gggacatgcg taggtgctgc gagcagagag     2160

ggattcctcg gaggtcatct gttccatctt cttgcctatg caaatgcctg cctgaagctg     2220

ctggaggctg gctttgtacc ggactttgta cagggaacca gggaaacgaa tgcagagtgc     2280

tcctgacatt gcctgtcact ttttcccatg atactctggc ttcacagttt ggagactgcc     2340

agggaccatg ttttgcccat tgactattac tttccacccc agaagacctg cctgatctgt     2400

ggagatgaag cttctgggtg tcactatgga gctctcacat gtggaagctg caaggtcttc     2460

ttcaaaagag ccgctgaagg gaaacagaag tacctgtgcg ccagcagaaa tgattgcact     2520

attgataaat tccgaaggaa aaattgtcca tcttgtcgtc ttcggaaatg ttatgaagca     2580

gggatgactc tgggagcccg gaagctgaag aaacttggta atctgaaact acaggaggaa     2640

ggagaggctt ccagcaccac cagccccact gaggagacaa cccagaagct gacagtgtca     2700

cacattgaag gctatgaatg tcagcccatc tttctgaatg tcctggaagc cattgagcca     2760

ggtgtagtgt gtgctggaca cgacaacaac cagcccgact cctttgcagc cttgctctct     2820

agcctcaatg aactgggaga gagacagctt gtacacgtgg tcaagtgggc caaggccttg     2880

cctggcttcc gcaacttaca cgtggacgac cagatggctg tcattcagta ctcctggatg     2940

gggctcatgg tgtttgccat gggctggcga tccttcacca atgtcaactc caggatgctc     3000

tacttcgccc ctgatctggt tttcaatgag taccgcatgc acaagtcccg gatgtacagc     3060

cagtgtgtcc gaatgaggca cctctctcaa gagtttggat ggctccaaat caccccccag     3120

gaattcctgt gcatgaaagc actgctactc ttcagcatta ttccagtgga tgggctgaaa     3180

aatcaaaaat tctttgatga acttcgaatg aactacatca aggaactcga tcgtatcatt     3240

gcatgcaaaa gaaaaaatcc cacatcctgc tcaagacgct tctaccagct caccaagctc     3300

ctggactccg tgcagcctat tgcgagagag ctgcatcagt tcacttttga cctgctaatc     3360

aagtcacaca tggtgagcgt ggactttccg gaaatgatgg cagagatcat ctctgtgcaa     3420

gtgcccaaga tcctttctgg gaaagtcaag cccatctatt tccacaccca gtgaagcatt     3480

ggaaacccta tttccccacc ccagctcatg ccccctttca gatgtcttct gcctgttata     3540

actctgcact actcctctgc agtgccttgg ggaatttcct ctattgatgt acagtctgtc     3600

atgaacatgt tcctgaattc tatttgctgg gctttttttt tctctttctc tcctttcttt     3660

ttcttcttcc ctccctatct aaccctccca tggcaccttc agactttgct tcccattgtg     3720

gctcctatct gtgttttgaa tggtgttgta tgcctttaaa tctgtgatga tcctcatatg     3780

gcccagtgtc aagttgtgct tgtttacagc actactctgt gccagccaca caaacgttta     3840

cttatcttat gccacgggaa gtttagagag ctaagattat ctggggaaat caaaacaaaa     3900

acaagcaaac aaaaaaaaaa agcaaaaaca aaacaaaaaa taagccaaaa aaccttgcta     3960

gtgttttttc ctcaaaaata aataaataaa taaataaata cgtacataca tacacacata     4020

catacaaaca tatagaaatc cccaaagagg ccaatagtga cgagaaggtg aaaattgcag     4080

gcccatgggg agttactgat tttttcatct cctccctcca cgggagactt tattttctgc     4140

caatggctat tgccattaga gggcagagtg accccagagc tgagttgggc aggggggtgg     4200

acagagagga gaggacaagg agggcaatgg agcatcagta cctgcccaca gccttggtcc     4260

ctgggggcta gactgctcaa ctgtggagca attcattata ctgaaaatgt gcttgttgtt     4320

gaaaatttgt ctgcatgtta atgcctcacc cccaaaccct tttctctctc actctctgcc     4380

tccaacttca gattgacttt caatagtttt tctaagacct ttgaactgaa tgttctcttc     4440

agccaaaact tggcgacttc cacagaaaag tctgaccact gagaagaagg agagcagaga     4500

tttaaccctt tgtaaggccc catttggatc caggtctgct ttctcatgtg tgagtcaggg     4560

aggagctgga gccagaggag aagaaaatga tagcttggct gttctcctgc ttaggacact     4620

gactgaatag ttaaactctc actgccacta ccttttcccc acctttaaaa gacctgaatg     4680

aagttttctg ccaaactccg tgaagccaca agcaccttat gtcctccctt cagtgttttg     4740

tgggcctgaa tttcatcaca ctgcatttca gccatggtca tcaagcctgt ttgcttcttt     4800

tgggcatgtt cacagattct ctgttaagag cccccaccac caagaaggtt agcaggccaa     4860

cagctctgac atctatctgt agatgccagt agtcacaaag atttcttacc aactctcaga     4920

tcgctggagc ccttagacaa actggaaaga aggcatcaaa gggatcaggc aagctgggcg     4980

tcttgccctt gtcccccaga gatgataccc tcccagcaag tggagaagtt ctcacttcct     5040

tctttagagc agctaaaggg gctacccaga tcagggttga agagaaaact caattaccag     5100

ggtgggaaga atgaaggcac tagaaccaga aaccctgcaa atgctcttct tgtcacccag     5160

catatccacc tgcagaagtc atgagaagag agaaggaaca aagaggagac tctgactact     5220

gaattaaaat cttcagcggc aaagcctaaa gccagatgga caccatctgg tgagtttact     5280

catcatcctc ctctgctgct gattctgggc tctgacattg cccatactca ctcagattcc     5340

ccacctttgt tgctgcctct tagtcagagg gaggccaaac cattgagact ttctacagaa     5400

ccatggcttc tttcggaaag gtctggttgg tgtggctcca atactttgcc acccatgaac     5460

tcagggtgtg ccctgggaca ctggttttat atagtctttt ggcacacctg tgttctgttg     5520

acttcgttct tcaagcccaa gtgcaaggga aaatgtccac ctactttctc atcttggcct     5580

ctgcctcctt acttagctct taatctcatc tgttgaactc aagaaatcaa gggccagtca     5640

tcaagctgcc cattttaatt gattcactct gtttgttgag aggatagttt ctgagtgaca     5700

tgatatgatc cacaagggtt tccttccctg atttctgcat tgatattaat agccaaacga     5760

acttcaaaac agctttaaat aacaagggag aggggaacct aagatgagta atatgccaat     5820

ccaagactgc tggagaaaac taaagctgac aggttccctt tttggggtgg gatagacatg     5880

ttctggtttt ctttattatt acacaatctg gctcatgtac aggatcactt ttagctgttt     5940

taaacagaaa aaaatatcca ccactctttt cagttacact aggttacatt ttaataggtc     6000

ctttacatct gttttggaat gattttcatc ttttgtgata cacagattga attatatcat     6060

tttcatatct ctccttgtaa atactagaag ctctccttta catttctcta tcaaattttt     6120

catctttatg ggtttcccaa ttgtgactct tgtcttcatg aatatatgtt tttcatttgc     6180

aaaagccaaa aatcagtgaa acagcagtgt aattaaaagc aacaactgga ttactccaaa     6240

tttccaaatg acaaaactag ggaaaaatag cctacacaag cctttaggcc tactctttct     6300

gtgcttgggt ttgagtgaac aaaggagatt ttagcttggc tctgttctcc catggatgaa     6360

aggaggagga tttttttttt cttttggcca ttgatgttct agccaatgta attgacagaa     6420

gtctcatttt gcatgcgctc tgctctacaa acagagttgg tatggttggt atactgtact     6480

cacctgtgag ggactggcca ctcagaccca cttagctggt gagctagaag atgaggatca     6540

ctcactggaa aagtcacaag gaccatctcc aaacaagttg gcagtgctcg atgtggacga     6600

agagtgagga agagaaaaag aaggagcacc agggagaagg ctccgtctgt gctgggcagc     6660

agacagctgc caggatcacg aactctgtag tcaaagaaaa gagtcgtgtg gcagtttcag     6720

ctctcgttca ttgggcagct cgcctaggcc cagcctctga gctgacatgg gagttgttgg     6780

attctttgtt tcatagcttt ttctatgcca taggcaatat tgttgttctt ggaaagttta     6840

ttattttttt aactccctta ctctgagaaa gggatatttt gaaggactgt catatatctt     6900

tgaaaaaaga aaatctgtaa tacatatatt tttatgtatg ttcactggca ctaaaaaata     6960

tagagagctt cattctgtcc tttgggtagt tgctgaggta attgtccagg ttgaaaaata     7020

atgtgctgat gctagagtcc ctctctgtcc atactctact tctaaataca tataggcata     7080

catagcaagt tttatttgac ttgtacttta agagaaaata tgtccaccat ccacatgatg     7140

cacaaatgag ctaacattga gcttcaagta gcttctaagt gtttgtttca ttaggcacag     7200

cacagatgtg gcctttcccc ccttctctcc cttgatatct ggcagggcat aaaggcccag     7260

gccacttcct ctgccccttc ccagccctgc accaaagctg catttcagga gactctctcc     7320

agacagccca gtaactaccc gagcatggcc cctgcatagc cctggaaaaa taagaggctg     7380

actgtctacg aattatcttg tgccagttgc ccaggtgaga gggcactggg ccaagggagt     7440

ggttttcatg tttgacccac tacaaggggt catgggaatc aggaatgcca aagcaccaga     7500

tcaaatccaa aacttaaagt caaaataagc cattcagcat gttcagtttc ttggaaaagg     7560

aagtttctac ccctgatgcc tttgtaggca gatctgttct caccattaat ctttttgaaa     7620

atcttttaaa gcagttttta aaaagagaga tgaaagcatc acattatata accaaagatt     7680

acattgtacc tgctaagata ccaaaattca taagggcagg gggggagcaa gcattagtgc     7740

ctctttgata agctgtccaa agacagacta aaggactctg ctggtgactg acttataaga     7800

gctttgtggg tttttttttc cctaataata tacatgttta gaagaattga aaataatttc     7860

gggaaaatgg gattatgggt ccttcactaa gtgattttat aagcagaact ggctttcctt     7920

ttctctagta gttgctgagc aaattgttga agctccatca ttgcatggtt ggaaatggag     7980

ctgttcttag ccactgtgtt tgctagtgcc catgttagct tatctgaaga tgtgaaaccc     8040

ttgctgataa gggagcattt aaagtactag attttgcact agagggacag caggcagaaa     8100

tccttatttc tgcccacttt ggatggcaca aaaagttatc tgcagttgaa ggcagaaagt     8160

tgaaatacat tgtaaatgaa tatttgtatc catgtttcaa aattgaaata tatatatata     8220

tatatatata tatatatata tatatatagt gtgtgtgtgt gttctgatag ctttaacttt     8280

ctctgcatct ttatatttgg ttccagatca cacctgatgc catgtacttg tgagagagga     8340

tgcagttttg ttttggaagc tctctcagaa caaacaagac acctggattg atcagttaac     8400

taaaagtttt ctcccctatt gggtttgacc cacaggtcct gtgaaggagc agagggataa     8460

aaagagtaga ggacatgata cattgtactt tactagttca agacagatga atgtggaaag     8520

cataaaaact caatggaact gactgagatt taccacaggg aaggcccaaa cttggggcca     8580

aaagcctacc caagtgattg accagtggcc ccctaatggg acctgagctg ttggaagaag     8640

agaactgttc cttggtcttc accatccttg tgagagaagg gcagtttcct gcattggaac     8700

ctggagcaag cgctctatct ttcacacaaa ttccctcacc tgagattgag gtgctcttgt     8760

tactgggtgt ctgtgtgctg taattctggt tttggatatg ttctgtaaag attttgacaa     8820

atgaaaatgt gtttttctct gttaaaactt gtcagagtac tagaagttgt atctctgtag     8880

gtgcaggtcc atttctgccc acaggtaggg tgtttttctt tgattaagag attgacactt     8940

ctgttgccta ggacctccca actcaaccat ttctaggtga aggcagaaaa atccacatta     9000

gttactcctc ttcagacatt tcagctgaga taacaaatct tttggaattt tttcacccat     9060

agaaagagtg gtagatattt gaatttagca ggtggagttt catagtaaaa acagcttttg     9120

actcagcttt gatttatcct catttgattt ggccagaaag taggtaatat gcattgattg     9180

gcttctgatt ccaattcagt atagcaaggt gctaggtttt ttcctttccc cacctgtctc     9240

ttagcctggg gaattaaatg agaagcctta gaatgggtgg cccttgtgac ctgaaacact     9300

tcccacataa gctacttaac aagattgtca tggagctgca gattccattg cccaccaaag     9360

actagaacac acacatatcc atacaccaaa ggaaagacaa ttctgaaatg ctgtttctct     9420

ggtggttccc tctctggctg ctgcctcaca gtatgggaac ctgtactctg cagaggtgac     9480

aggccagatt tgcattatct cacaacctta gcccttggtg ctaactgtcc tacagtgaag     9540

tgcctggggg gttgtcctat cccataagcc acttggatgc tgacagcagc caccatcaga     9600

atgacccacg caaaaaaaag aaaaaaaaaa ttaaaaagtc ccctcacaac ccagtgacac     9660

ctttctgctt tcctctagac tggaacattg attagggagt gcctcagaca tgacattctt     9720

gtgctgtcct tggaattaat ctggcagcag gagggagcag actatgtaaa cagagataaa     9780

aattaatttt caatattgaa ggaaaaaaga aataagaaga gagagagaaa gaaagcatca     9840

cacaaagatt ttcttaaaag aaacaatttt gcttgaaatc tctttagatg gggctcattt     9900

ctcacggtgg cacttggcct ccactgggca gcaggaccag ctccaagcgc tagtgttctg     9960

ttctcttttt gtaatcttgg aatcttttgt tgctctaaat acaattaaaa atggcagaaa    10020

cttgtttgtt ggactacatg tgtgactttg ggtctgtctc tgcctctgct ttcagaaatg    10080

tcatccattg tgtaaaatat tggcttactg gtctgccagc taaaacttgg ccacatcccc    10140

tgttatggct gcaggatcga gttattgtta acaaagagac ccaagaaaag ctgctaatgt    10200

cctcttatca ttgttgttaa tttgttaaaa cataaagaaa tctaaaattt caaaaaa       10257


<210>  52
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Glu Lys Phe Arg Val Gly Asn Cys Lys His Leu Lys 
625                 630                 635                 640 


Met Thr Arg Pro 
                


<210>  53
<211>  3812
<212>  DNA
<213>  Homo sapiens

<400>  53
gcggagagaa ccctctgttt tcccccactc tctctccacc tcctcctgcc ttccccaccc       60

cgagtgcgga gccagagatc aaaagatgaa aaggcagtca ggtcttcagt agccaaaaaa      120

caaaacaaac aaaaacaaaa aagccgaaat aaaagaaaaa gataataact cagttcttat      180

ttgcacctac ttcagtggac actgaatttg gaaggtggag gattttgttt ttttctttta      240

agatctgggc atcttttgaa tctacccttc aagtattaag agacagactg tgagcctagc      300

agggcagatc ttgtccaccg tgtgtcttct tctgcacgag actttgaggc tgtcagagcg      360

ctttttgcgt ggttgctccc gcaagtttcc ttctctggag cttcccgcag gtgggcagct      420

agctgcagcg actaccgcat catcacagcc tgttgaactc ttctgagcaa gagaagggga      480

ggcggggtaa gggaagtagg tggaagattc agccaagctc aaggatggaa gtgcagttag      540

ggctgggaag ggtctaccct cggccgccgt ccaagaccta ccgaggagct ttccagaatc      600

tgttccagag cgtgcgcgaa gtgatccaga acccgggccc caggcaccca gaggccgcga      660

gcgcagcacc tcccggcgcc agtttgctgc tgctgcagca gcagcagcag cagcagcagc      720

agcagcagca gcagcagcag cagcagcagc agcagcagca gcaagagact agccccaggc      780

agcagcagca gcagcagggt gaggatggtt ctccccaagc ccatcgtaga ggccccacag      840

gctacctggt cctggatgag gaacagcaac cttcacagcc gcagtcggcc ctggagtgcc      900

accccgagag aggttgcgtc ccagagcctg gagccgccgt ggccgccagc aaggggctgc      960

cgcagcagct gccagcacct ccggacgagg atgactcagc tgccccatcc acgttgtccc     1020

tgctgggccc cactttcccc ggcttaagca gctgctccgc tgaccttaaa gacatcctga     1080

gcgaggccag caccatgcaa ctccttcagc aacagcagca ggaagcagta tccgaaggca     1140

gcagcagcgg gagagcgagg gaggcctcgg gggctcccac ttcctccaag gacaattact     1200

tagggggcac ttcgaccatt tctgacaacg ccaaggagtt gtgtaaggca gtgtcggtgt     1260

ccatgggcct gggtgtggag gcgttggagc atctgagtcc aggggaacag cttcgggggg     1320

attgcatgta cgccccactt ttgggagttc cacccgctgt gcgtcccact ccttgtgccc     1380

cattggccga atgcaaaggt tctctgctag acgacagcgc aggcaagagc actgaagata     1440

ctgctgagta ttcccctttc aagggaggtt acaccaaagg gctagaaggc gagagcctag     1500

gctgctctgg cagcgctgca gcagggagct ccgggacact tgaactgccg tctaccctgt     1560

ctctctacaa gtccggagca ctggacgagg cagctgcgta ccagagtcgc gactactaca     1620

actttccact ggctctggcc ggaccgccgc cccctccgcc gcctccccat ccccacgctc     1680

gcatcaagct ggagaacccg ctggactacg gcagcgcctg ggcggctgcg gcggcgcagt     1740

gccgctatgg ggacctggcg agcctgcatg gcgcgggtgc agcgggaccc ggttctgggt     1800

caccctcagc cgccgcttcc tcatcctggc acactctctt cacagccgaa gaaggccagt     1860

tgtatggacc gtgtggtggt ggtgggggtg gtggcggcgg cggcggcggc ggcggcggcg     1920

gcggcggcgg cggcggcggc ggcgaggcgg gagctgtagc cccctacggc tacactcggc     1980

cccctcaggg gctggcgggc caggaaagcg acttcaccgc acctgatgtg tggtaccctg     2040

gcggcatggt gagcagagtg ccctatccca gtcccacttg tgtcaaaagc gaaatgggcc     2100

cctggatgga tagctactcc ggaccttacg gggacatgcg tttggagact gccagggacc     2160

atgttttgcc cattgactat tactttccac cccagaagac ctgcctgatc tgtggagatg     2220

aagcttctgg gtgtcactat ggagctctca catgtggaag ctgcaaggtc ttcttcaaaa     2280

gagccgctga agggaaacag aagtacctgt gcgccagcag aaatgattgc actattgata     2340

aattccgaag gaaaaattgt ccatcttgtc gtcttcggaa atgttatgaa gcagggatga     2400

ctctgggaga aaaattccgg gttggcaatt gcaagcatct caaaatgacc agaccctgaa     2460

gaaaggctga cttgcctcat tcaaaatgag ggctctagag ggctctagtg gatagtctgg     2520

agaaacctgg cgtctgaggc ttaggagctt aggtttttgc tcctcaacac agactttgac     2580

gttggggttg ggggctactc tcttgattgc tgactccctc cagcgggacc aatagtgttt     2640

tcctacctca cagggatgtt gtgaggacgg gctgtagaag taatagtggt taccattcat     2700

gtagttgtga gtatcatgat tattgtttcc tgtaatgtgg cttggcattg gcaaagtgct     2760

ttttgattgt tcttgatcac atatgatggg ggccaggcac tgactcaggc ggatgcagtg     2820

aagctctggc tcagtcgctt gcttttcgtg gtgtgctgcc aggaagaaac tttgctgatg     2880

ggactcaagg tgtcaccttg gacaagaagc aactgtgtct gtctgaggtt cctgtggcca     2940

tctttatttg tgtattaggc aattcgtatt tcccccttag gttctagcct tctggatccc     3000

agccagtgac ctagatctta gcctcaggcc ctgtcactga gctgaaggta gtagctgatc     3060

cacagaagtt cagtaaacaa ggaccagatt tctgcttctc caggagaaga agccagccaa     3120

cccctctctt caaacacact gagagactac agtccgactt tccctcttac atctagcctt     3180

actgtagcca cactccttga ttgctctctc acatcacatg cttctcttca tcagttgtaa     3240

gcctctcatt cttctcccaa gccagactca aatattgtat tgatgtcaaa gaagaatcac     3300

ttagagtttg gaatatcttg ttctctctct gctccatagc ttccatattg acaccagttt     3360

ctttctagtg gagaagtgga gtctgtgaag ccagggaaac acacatgtga gagtcagaag     3420

gactctccct gacttgcctg gggcctgtct ttcccacctt ctccagtctg tctaaacaca     3480

cacacacaca cacacacaca cacacacacg ctctctctct ctctcccccc ccaacacaca     3540

cacactctct ctctctctca cacacacaca catacacaca cacttctttc tctttcccct     3600

gactcagcaa cattctggag aaaagccaag gaaggacttc aggaggggag tttccccctt     3660

ctcagggcag aattttaatc tccagaccaa caagaagttc cctaatgtgg attgaaaggc     3720

taatgaggtt tatttttaac tactttctat ttgtttgaat gttgcatatt tctactagtg     3780

aaattttccc ttaataaagc cattaataca cc                                   3812


<210>  54
<211>  648
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Ala Val Val Val Ser Glu Arg Ile Leu Arg Val 
625                 630                 635                 640 


Phe Gly Val Ser Glu Trp Leu Pro 
                645             


<210>  55
<211>  2627
<212>  DNA
<213>  Homo sapiens

<400>  55
gcggagagaa ccctctgttt tcccccactc tctctccacc tcctcctgcc ttccccaccc       60

cgagtgcgga gccagagatc aaaagatgaa aaggcagtca ggtcttcagt agccaaaaaa      120

caaaacaaac aaaaacaaaa aagccgaaat aaaagaaaaa gataataact cagttcttat      180

ttgcacctac ttcagtggac actgaatttg gaaggtggag gattttgttt ttttctttta      240

agatctgggc atcttttgaa tctacccttc aagtattaag agacagactg tgagcctagc      300

agggcagatc ttgtccaccg tgtgtcttct tctgcacgag actttgaggc tgtcagagcg      360

ctttttgcgt ggttgctccc gcaagtttcc ttctctggag cttcccgcag gtgggcagct      420

agctgcagcg actaccgcat catcacagcc tgttgaactc ttctgagcaa gagaagggga      480

ggcggggtaa gggaagtagg tggaagattc agccaagctc aaggatggaa gtgcagttag      540

ggctgggaag ggtctaccct cggccgccgt ccaagaccta ccgaggagct ttccagaatc      600

tgttccagag cgtgcgcgaa gtgatccaga acccgggccc caggcaccca gaggccgcga      660

gcgcagcacc tcccggcgcc agtttgctgc tgctgcagca gcagcagcag cagcagcagc      720

agcagcagca gcagcagcag cagcagcagc agcagcagca gcaagagact agccccaggc      780

agcagcagca gcagcagggt gaggatggtt ctccccaagc ccatcgtaga ggccccacag      840

gctacctggt cctggatgag gaacagcaac cttcacagcc gcagtcggcc ctggagtgcc      900

accccgagag aggttgcgtc ccagagcctg gagccgccgt ggccgccagc aaggggctgc      960

cgcagcagct gccagcacct ccggacgagg atgactcagc tgccccatcc acgttgtccc     1020

tgctgggccc cactttcccc ggcttaagca gctgctccgc tgaccttaaa gacatcctga     1080

gcgaggccag caccatgcaa ctccttcagc aacagcagca ggaagcagta tccgaaggca     1140

gcagcagcgg gagagcgagg gaggcctcgg gggctcccac ttcctccaag gacaattact     1200

tagggggcac ttcgaccatt tctgacaacg ccaaggagtt gtgtaaggca gtgtcggtgt     1260

ccatgggcct gggtgtggag gcgttggagc atctgagtcc aggggaacag cttcgggggg     1320

attgcatgta cgccccactt ttgggagttc cacccgctgt gcgtcccact ccttgtgccc     1380

cattggccga atgcaaaggt tctctgctag acgacagcgc aggcaagagc actgaagata     1440

ctgctgagta ttcccctttc aagggaggtt acaccaaagg gctagaaggc gagagcctag     1500

gctgctctgg cagcgctgca gcagggagct ccgggacact tgaactgccg tctaccctgt     1560

ctctctacaa gtccggagca ctggacgagg cagctgcgta ccagagtcgc gactactaca     1620

actttccact ggctctggcc ggaccgccgc cccctccgcc gcctccccat ccccacgctc     1680

gcatcaagct ggagaacccg ctggactacg gcagcgcctg ggcggctgcg gcggcgcagt     1740

gccgctatgg ggacctggcg agcctgcatg gcgcgggtgc agcgggaccc ggttctgggt     1800

caccctcagc cgccgcttcc tcatcctggc acactctctt cacagccgaa gaaggccagt     1860

tgtatggacc gtgtggtggt ggtgggggtg gtggcggcgg cggcggcggc ggcggcggcg     1920

gcggcggcgg cggcggcggc ggcgaggcgg gagctgtagc cccctacggc tacactcggc     1980

cccctcaggg gctggcgggc caggaaagcg acttcaccgc acctgatgtg tggtaccctg     2040

gcggcatggt gagcagagtg ccctatccca gtcccacttg tgtcaaaagc gaaatgggcc     2100

cctggatgga tagctactcc ggaccttacg gggacatgcg tttggagact gccagggacc     2160

atgttttgcc cattgactat tactttccac cccagaagac ctgcctgatc tgtggagatg     2220

aagcttctgg gtgtcactat ggagctctca catgtggaag ctgcaaggtc ttcttcaaaa     2280

gagccgctga agggaaacag aagtacctgt gcgccagcag aaatgattgc actattgata     2340

aattccgaag gaaaaattgt ccatcttgtc gtcttcggaa atgttatgaa gcagggatga     2400

ctctgggagc agctgttgtt gtttctgaaa gaatcttgag ggtgtttgga gtctcagaat     2460

ggcttcctta aagactacct tcagactctc agctgctcat ccacaacaga gatcagcctt     2520

tctttgtaga tgattcattc ctggctgcat ttgaaaacca catattgtta attgcttgac     2580

gaatttaaat cccttgacta cttttcattt caaaaaaaaa aaaaaaa                   2627


<210>  56
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Asn Thr Arg Arg Lys 
    530                 535                 540                 


Arg Leu Trp Lys Leu Ile Ile Arg Ser Ile Asn Ser Cys Ile Cys Ser 
545                 550                 555                 560 


Pro Arg Glu Thr Glu Val Pro Val Arg Gln Gln Lys 
                565                 570         


<210>  57
<211>  3729
<212>  DNA
<213>  Homo sapiens

<400>  57
gcggagagaa ccctctgttt tcccccactc tctctccacc tcctcctgcc ttccccaccc       60

cgagtgcgga gccagagatc aaaagatgaa aaggcagtca ggtcttcagt agccaaaaaa      120

caaaacaaac aaaaacaaaa aagccgaaat aaaagaaaaa gataataact cagttcttat      180

ttgcacctac ttcagtggac actgaatttg gaaggtggag gattttgttt ttttctttta      240

agatctgggc atcttttgaa tctacccttc aagtattaag agacagactg tgagcctagc      300

agggcagatc ttgtccaccg tgtgtcttct tctgcacgag actttgaggc tgtcagagcg      360

ctttttgcgt ggttgctccc gcaagtttcc ttctctggag cttcccgcag gtgggcagct      420

agctgcagcg actaccgcat catcacagcc tgttgaactc ttctgagcaa gagaagggga      480

ggcggggtaa gggaagtagg tggaagattc agccaagctc aaggatggaa gtgcagttag      540

ggctgggaag ggtctaccct cggccgccgt ccaagaccta ccgaggagct ttccagaatc      600

tgttccagag cgtgcgcgaa gtgatccaga acccgggccc caggcaccca gaggccgcga      660

gcgcagcacc tcccggcgcc agtttgctgc tgctgcagca gcagcagcag cagcagcagc      720

agcagcagca gcagcagcag cagcagcagc agcagcagca gcaagagact agccccaggc      780

agcagcagca gcagcagggt gaggatggtt ctccccaagc ccatcgtaga ggccccacag      840

gctacctggt cctggatgag gaacagcaac cttcacagcc gcagtcggcc ctggagtgcc      900

accccgagag aggttgcgtc ccagagcctg gagccgccgt ggccgccagc aaggggctgc      960

cgcagcagct gccagcacct ccggacgagg atgactcagc tgccccatcc acgttgtccc     1020

tgctgggccc cactttcccc ggcttaagca gctgctccgc tgaccttaaa gacatcctga     1080

gcgaggccag caccatgcaa ctccttcagc aacagcagca ggaagcagta tccgaaggca     1140

gcagcagcgg gagagcgagg gaggcctcgg gggctcccac ttcctccaag gacaattact     1200

tagggggcac ttcgaccatt tctgacaacg ccaaggagtt gtgtaaggca gtgtcggtgt     1260

ccatgggcct gggtgtggag gcgttggagc atctgagtcc aggggaacag cttcgggggg     1320

attgcatgta cgccccactt ttgggagttc cacccgctgt gcgtcccact ccttgtgccc     1380

cattggccga atgcaaaggt tctctgctag acgacagcgc aggcaagagc actgaagata     1440

ctgctgagta ttcccctttc aagggaggtt acaccaaagg gctagaaggc gagagcctag     1500

gctgctctgg cagcgctgca gcagggagct ccgggacact tgaactgccg tctaccctgt     1560

ctctctacaa gtccggagca ctggacgagg cagctgcgta ccagagtcgc gactactaca     1620

actttccact ggctctggcc ggaccgccgc cccctccgcc gcctccccat ccccacgctc     1680

gcatcaagct ggagaacccg ctggactacg gcagcgcctg ggcggctgcg gcggcgcagt     1740

gccgctatgg ggacctggcg agcctgcatg gcgcgggtgc agcgggaccc ggttctgggt     1800

caccctcagc cgccgcttcc tcatcctggc acactctctt cacagccgaa gaaggccagt     1860

tgtatggacc gtgtggtggt ggtgggggtg gtggcggcgg cggcggcggc ggcggcggcg     1920

gcggcggcgg cggcggcggc ggcgaggcgg gagctgtagc cccctacggc tacactcggc     1980

cccctcaggg gctggcgggc caggaaagcg acttcaccgc acctgatgtg tggtaccctg     2040

gcggcatggt gagcagagtg ccctatccca gtcccacttg tgtcaaaagc gaaatgggcc     2100

cctggatgga tagctactcc ggaccttacg gggacatgcg aaatacccga agaaagagac     2160

tctggaaact cattatcagg tctatcaact cttgtatttg ttctcccagg gaaacagaag     2220

tacctgtgcg ccagcagaaa tgattgcact attgataaat tccgaaggaa aaattgtcca     2280

tcttgtcgtc ttcggaaatg ttatgaagca gggatgactc tgggagaaaa attccgggtt     2340

ggcaattgca agcatctcaa aatgaccaga ccctgaagaa aggctgactt gcctcattca     2400

aaatgagggc tctagagggc tctagtggat agtctggaga aacctggcgt ctgaggctta     2460

ggagcttagg tttttgctcc tcaacacaga ctttgacgtt ggggttgggg gctactctct     2520

tgattgctga ctccctccag cgggaccaat agtgttttcc tacctcacag ggatgttgtg     2580

aggacgggct gtagaagtaa tagtggttac cattcatgta gttgtgagta tcatgattat     2640

tgtttcctgt aatgtggctt ggcattggca aagtgctttt tgattgttct tgatcacata     2700

tgatgggggc caggcactga ctcaggcgga tgcagtgaag ctctggctca gtcgcttgct     2760

tttcgtggtg tgctgccagg aagaaacttt gctgatggga ctcaaggtgt caccttggac     2820

aagaagcaac tgtgtctgtc tgaggttcct gtggccatct ttatttgtgt attaggcaat     2880

tcgtatttcc cccttaggtt ctagccttct ggatcccagc cagtgaccta gatcttagcc     2940

tcaggccctg tcactgagct gaaggtagta gctgatccac agaagttcag taaacaagga     3000

ccagatttct gcttctccag gagaagaagc cagccaaccc ctctcttcaa acacactgag     3060

agactacagt ccgactttcc ctcttacatc tagccttact gtagccacac tccttgattg     3120

ctctctcaca tcacatgctt ctcttcatca gttgtaagcc tctcattctt ctcccaagcc     3180

agactcaaat attgtattga tgtcaaagaa gaatcactta gagtttggaa tatcttgttc     3240

tctctctgct ccatagcttc catattgaca ccagtttctt tctagtggag aagtggagtc     3300

tgtgaagcca gggaaacaca catgtgagag tcagaaggac tctccctgac ttgcctgggg     3360

cctgtctttc ccaccttctc cagtctgtct aaacacacac acacacacac acacacacac     3420

acacacgctc tctctctctc tcccccccca acacacacac actctctctc tctctcacac     3480

acacacacat acacacacac ttctttctct ttcccctgac tcagcaacat tctggagaaa     3540

agccaaggaa ggacttcagg aggggagttt cccccttctc agggcagaat tttaatctcc     3600

agaccaacaa gaagttccct aatgtggatt gaaaggctaa tgaggtttat ttttaactac     3660

tttctatttg tttgaatgtt gcatatttct actagtgaaa ttttccctta ataaagccat     3720

taatacacc                                                             3729


<210>  58
<211>  899
<212>  PRT
<213>  Mus musculus

<400>  58

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Ala Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Asn Ile Ala 
        35                  40                  45              


Pro Pro Gly Ala Cys Leu Gln Gln Arg Gln Glu Thr Ser Pro Arg Arg 
    50                  55                  60                  


Arg Arg Arg Gln Gln His Thr Glu Asp Gly Ser Pro Gln Ala His Ile 
65                  70                  75                  80  


Arg Gly Pro Thr Gly Tyr Leu Ala Leu Glu Glu Glu Gln Gln Pro Ser 
                85                  90                  95      


Gln Gln Gln Ala Ala Ser Glu Gly His Pro Glu Ser Ser Cys Leu Pro 
            100                 105                 110         


Glu Pro Gly Ala Ala Thr Ala Pro Gly Lys Gly Leu Pro Gln Gln Pro 
        115                 120                 125             


Pro Ala Pro Pro Asp Gln Asp Asp Ser Ala Ala Pro Ser Thr Leu Ser 
    130                 135                 140                 


Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser Ala Asp Ile 
145                 150                 155                 160 


Lys Asp Ile Leu Asn Glu Ala Gly Thr Met Gln Leu Leu Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln His Gln Gln Gln His Gln Gln His Gln Gln Gln 
            180                 185                 190         


Gln Glu Val Ile Ser Glu Gly Ser Ser Ala Arg Ala Arg Glu Ala Thr 
        195                 200                 205             


Gly Ala Pro Ser Ser Ser Lys Asp Ser Tyr Leu Gly Gly Asn Ser Thr 
    210                 215                 220                 


Ile Ser Asp Ser Ala Lys Glu Leu Cys Lys Ala Val Ser Val Ser Met 
225                 230                 235                 240 


Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser Pro Gly Glu Gln Leu 
                245                 250                 255     


Arg Gly Asp Cys Met Tyr Ala Ser Leu Leu Gly Gly Pro Pro Ala Val 
            260                 265                 270         


Arg Pro Thr Pro Cys Ala Pro Leu Pro Glu Cys Lys Gly Leu Pro Leu 
        275                 280                 285             


Asp Glu Gly Pro Gly Lys Ser Thr Glu Glu Thr Ala Glu Tyr Ser Ser 
    290                 295                 300                 


Phe Lys Gly Gly Tyr Ala Lys Gly Leu Glu Gly Glu Ser Leu Gly Cys 
305                 310                 315                 320 


Ser Gly Ser Ser Glu Ala Gly Ser Ser Gly Thr Leu Glu Ile Pro Ser 
                325                 330                 335     


Ser Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp Glu Ala Ala Ala Tyr 
            340                 345                 350         


Gln Asn Arg Asp Tyr Tyr Asn Phe Pro Leu Ala Leu Ser Gly Pro Pro 
        355                 360                 365             


His Pro Pro Pro Pro Thr His Pro His Ala Arg Ile Lys Leu Glu Asn 
    370                 375                 380                 


Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala Ala Ala Gln Cys Arg 
385                 390                 395                 400 


Tyr Gly Asp Leu Gly Ser Leu His Gly Gly Ser Val Ala Gly Pro Ser 
                405                 410                 415     


Thr Gly Ser Pro Pro Ala Thr Thr Ser Ser Ser Trp His Thr Leu Phe 
            420                 425                 430         


Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Gly Gly Gly Gly Gly Ser 
        435                 440                 445             


Ser Ser Pro Ser Asp Ala Gly Pro Val Ala Pro Tyr Gly Tyr Thr Arg 
    450                 455                 460                 


Pro Pro Gln Gly Leu Thr Ser Gln Glu Ser Asp Tyr Ser Ala Ser Glu 
465                 470                 475                 480 


Val Trp Tyr Pro Gly Gly Val Val Asn Arg Val Pro Tyr Pro Ser Pro 
                485                 490                 495     


Asn Cys Val Lys Ser Glu Met Gly Pro Trp Met Glu Asn Tyr Ser Gly 
            500                 505                 510         


Pro Tyr Gly Asp Met Arg Leu Asp Ser Thr Arg Asp His Val Leu Pro 
        515                 520                 525             


Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu Ile Cys Gly Asp 
    530                 535                 540                 


Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys Gly Ser Cys Lys 
545                 550                 555                 560 


Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys Tyr Leu Cys Ala 
                565                 570                 575     


Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg Lys Asn Cys Pro 
            580                 585                 590         


Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala 
        595                 600                 605             


Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu 
    610                 615                 620                 


Asn Ser Asn Ala Gly Ser Pro Thr Glu Asp Pro Ser Gln Lys Met Thr 
625                 630                 635                 640 


Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val 
                645                 650                 655     


Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly His Asp Asn Asn 
            660                 665                 670         


Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly 
        675                 680                 685             


Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala Leu Pro Gly 
    690                 695                 700                 


Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile Gln Tyr Ser 
705                 710                 715                 720 


Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser Phe Thr Asn 
                725                 730                 735     


Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu 
            740                 745                 750         


Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val Arg Met Arg 
        755                 760                 765             


His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe 
    770                 775                 780                 


Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly 
785                 790                 795                 800 


Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys 
                805                 810                 815     


Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys 
            820                 825                 830         


Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser Val Gln Pro 
        835                 840                 845             


Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser 
    850                 855                 860                 


His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu Ile Ile Ser 
865                 870                 875                 880 


Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe 
                885                 890                 895     


His Thr Gln 
            


<210>  59
<211>  10063
<212>  DNA
<213>  Mus musculus

<400>  59
cagcgccccc tcggagatcc ctaggagcca gcctgctggg agaaccagag ggtccggagc       60

aaacctggag gctgagaggg catcagaggg gaaaagactg agctagccac tccagtgcca      120

tacagaagct taagggacgc accacgccag ccccagccca gcgacagcca acgcctgttg      180

cagagcggcg gcttcgaagc cgccgcccag gagctgccct ttcctcttcg gtgaagtttc      240

taaaagctgc gggagactca gaggaagcaa ggaaagtgtc cggtaggact acggctgcct      300

ttgtcctctt cccctctacc cttaccccct cctgggtccc ctctccagga gctgactagg      360

caggctttct ggccaaccct ctcccctaca cccccagctc tgccagccag tttgcacaga      420

ggtaaactcc ctttggctga gagtagggga gcttgttgca cattgcaagg aaggcttttg      480

ggagcccaga gactgaggag caacagcacg cccaggagag tccctggttc caggttctcg      540

cccctgcacc tcctcctgcc cgcccctcac cctgtgtgtg gtgttagaaa tgaaaagatg      600

aaaaggcagc tagggtttca gtagtcgaaa gcaaaacaaa agctaaaaga aaacaaaaag      660

aaaatagccc agttcttatt tgcacctgct tcagtggact ttgaatttgg aaggcagagg      720

atttcccctt ttccctcccg tcaaggtttg agcatctttt aatctgttct tcaagtattt      780

agagacaaac tgtgtaagta gcagggcaga tcctgtcttg cgcgtgcctt cctttactgg      840

agactttgag gttatctggg cactcccccc acccaccccc cctcctgcaa gttttcttcc      900

ccggagcttc ccgcaggtgg gcagctagct gcagatacta catcatcagt caggagaact      960

cttcagagca agagacgagg aggcaggata agggaattcg gtggaagcta cagacaagct     1020

caaggatgga ggtgcagtta gggctgggaa gggtctaccc acggccccca tccaagacct     1080

atcgaggagc gttccagaat ctgttccaga gcgtgcgcga agcgatccag aacccgggcc     1140

ccaggcaccc tgaggccgct aacatagcac ctcccggcgc ctgtttacag cagaggcagg     1200

agactagccc ccggcggcgg cggcggcagc agcacactga ggatggttct cctcaagccc     1260

acatcagagg ccccacaggc tacctggccc tggaggagga acagcagcct tcacagcagc     1320

aggcagcctc cgagggccac cctgagagca gctgcctccc cgagcctggg gcggccaccg     1380

ctcctggcaa ggggctgccg cagcagccac cagctcctcc agatcaggat gactcagctg     1440

ccccatccac gttgtccctg ctgggcccca ctttcccagg cttaagcagc tgctccgccg     1500

acattaaaga cattttgaac gaggccggca ccatgcaact tcttcagcag cagcaacaac     1560

agcagcagca ccaacagcag caccaacagc accaacagca gcaggaggta atctccgaag     1620

gcagcagcgc aagagccagg gaggccacgg gggctccctc ttcctccaag gatagttacc     1680

tagggggcaa ttcaaccata tctgacagtg ccaaggagtt gtgtaaagca gtgtctgtgt     1740

ccatgggatt gggtgtggaa gcattggaac atctgagtcc aggggaacag cttcggggag     1800

actgcatgta cgcgtcgctc ctgggaggtc cacccgcggt gcgtcccact ccttgtgcgc     1860

cgctgcccga atgcaaaggt cttcccctgg acgaaggccc aggcaaaagc actgaagaga     1920

ctgctgagta ttcctctttc aagggaggtt acgccaaagg attggaaggt gagagcttgg     1980

ggtgctctgg cagcagtgaa gcaggtagct ctgggacact tgagatcccg tcctctctgt     2040

ctctgtataa atctggagca ctagacgagg cagcagcata ccagaatcgc gactactaca     2100

actttccgct ggctctgtcc gggccgccgc accccccgcc ccctacccat ccacacgccc     2160

gtatcaagct ggagaaccca ttggactacg gcagcgcctg ggctgcggcg gcagcgcaat     2220

gccgctatgg ggacttgggt agtctacatg gagggagtgt agccgggccc agcactggat     2280

cgcccccagc caccacctct tcttcctggc atactctctt cacagctgaa gaaggccaat     2340

tatatgggcc aggaggcggg ggcggcagca gcagcccaag cgatgccggg cctgtagccc     2400

cctatggcta cactcggccc cctcaggggc tgacaagcca ggagagtgac tactctgcct     2460

ccgaagtgtg gtatcctggt ggagttgtga acagagtacc ctatcccagt cccaattgtg     2520

tcaaaagtga aatgggacct tggatggaga actactccgg accttatggg gacatgcgtt     2580

tggacagtac cagggaccat gttttaccca tcgactatta ctttccaccc cagaagacct     2640

gcctgatctg tggagatgaa gcttctggct gtcactacgg agctctcact tgtggcagct     2700

gcaaggtctt cttcaaaaga gccgctgaag ggaaacagaa gtatctatgt gccagcagaa     2760

acgattgtac cattgataaa tttcggagga aaaattgccc atcttgtcgt ctccggaaat     2820

gttatgaagc agggatgact ctgggagctc gtaagctgaa gaaacttgga aatctaaaac     2880

tacaggagga aggagaaaac tccaatgctg gcagccccac tgaggaccca tcccagaaga     2940

tgactgtatc acacattgaa ggctatgaat gtcagcctat ctttcttaac gtcctggaag     3000

ccattgagcc aggagtggtg tgtgccggac atgacaacaa ccaaccagat tcctttgctg     3060

ccttgttatc tagcctcaat gagcttggag agaggcagct tgtgcatgtg gtcaagtggg     3120

ccaaggcctt gcctggcttc cgcaacttgc atgtggatga ccagatggcg gtcattcagt     3180

attcctggat gggactgatg gtatttgcca tgggttggcg gtccttcact aatgtcaact     3240

ccaggatgct ctactttgca cctgacttgg ttttcaatga gtaccgcatg cacaagtctc     3300

ggatgtacag ccagtgtgtg aggatgaggc acctgtctca agagtttgga tggctccaaa     3360

taacccccca ggaattcctg tgcatgaaag cactgctgct cttcagcatt attccagtgg     3420

atgggctgaa aaatcaaaaa ttctttgatg aacttcgaat gaactacatc aaggaactcg     3480

atcgcatcat tgcatgcaaa agaaagaatc ccacatcctg ctcaaggcgc ttctaccagc     3540

tcaccaagct cctggattct gtgcagccta ttgcaagaga gctgcatcag ttcacttttg     3600

acctgctaat caagtcccat atggtgagcg tggactttcc tgaaatgatg gcagagatca     3660

tctctgtgca agtgcccaag atcctttctg ggaaagtcaa gcccatctat ttccacacac     3720

agtgaagatt tggaaaccct aatacccaaa acccaccttg ttccctttcc agatgtcttc     3780

tgcctgttat ataactctgc actacttctc tgcagtgcct tgggggaaat tcctctactg     3840

atgtacagtc tgtcgtgaac aggttcctca gttctatttc ctgggcttct ccttcttttt     3900

ttttcttctt ccctccctct ttcaccctcc catggcacat tttgaatctg ctgcgtattg     3960

tggctcctgc ctttgttttg atttctgttg tatttctttg aatctgtgat gatcctcttg     4020

tggcccagtg tcaattgtgc ttgtttatag cactgtgctg tgtgccaacc aagcaaatgt     4080

ttactcacct tatgccatgg caaatttaga gagctataag tatctggaga agaaacaaac     4140

agagagaata aaaagcaaaa acaaaaccaa aaaataaaaa aaacacaaac aaaaaacaaa     4200

accaacaaac aaaacatgct aggtttgttt cttcgtggta tacaaataaa cacataggat     4260

tcccaaagaa gccgacagtg actagaagaa agtaaaaaat tacaaatcca cgaggagtca     4320

ctgtttttgt tcatcctgtt tctctgtggg aaacttcagt tgttgttaat ggctattgcc     4380

attaaagagc aggttgaccc caaagcttta ctgatagggt agagagaaaa gaggacaagg     4440

agggcagatg gataaccatt acctccccac agcctttgtc cctgagtcct agagtgctca     4500

gttgcagtgt agttccttgt actgaaatgt gcttcttgtt tgaaaacttg tctgcatgtg     4560

aatgcctctt ccttccaatc cttttctctc ttaacctctg cttccaccct caattgactt     4620

tcaatagctt ttctcagagc tttgtactat atgctctctt tagccaaaac ttggccactt     4680

tcactgaagt tatgtcagtg agaagaaagt ggaaaggtct gactctttgg aaggctctat     4740

tcagatttat gttcatattt ccatgtgtga gccatagcgg agctttgtga ctggagtcag     4800

aggaaaagga agtgatggct tagccattct cccattagag atagtgaatg atgatgccat     4860

agtgcaatca tcctttcctc tgcttttaaa ggacctagag accccatgca gccacattct     4920

ccctgcacaa gtcttcagtg ttcagtggcc ctgaacttca ccaaaatgca tttaagccaa     4980

ggtggtaaag cttgtacact tctttggacg tgtttgtaga cactgctaag atctccctct     5040

caccaccacc acaaaggcta gcaggccagc agccacagca tctatgttta gatgttaata     5100

gcataaaaga catctcactc aatgtctttc atcaacagta aatttctgga gcccttagaa     5160

aaattggaaa gaaagcatca aagggaccag acaaaatggg catcttgccc ttgtcctcca     5220

gagacaatat attcctccca agtggagaaa tgtcaatttc ctcctcagaa caattaaagg     5280

ggctacccag accatggtgg aagagaaaac taagtaaccc agctgagaaa aatgaagaca     5340

ctagaaccag aaagcacagg actttttcct ttccatccag catacccatt ggcagaaata     5400

atggaaggaa aagagaaggc cagaagaaaa tacagactgc tgaagtcttc agaggcaaag     5460

tctaaagcca gatgaatacc atctggctag atgggcatca gtttgctcat cctcctctat     5520

tgccattgct gggctgactt tggccaaagt tacttcgaat ctccaccata gttgtcccct     5580

ctcagtcaga gggtgcagga ccactgaaac attctatcca ccgtgactct cattggacag     5640

atctggccgg tgtggctaca aatagactgc acccataaac tcagggcaag ccctgggtca     5700

ctggtttcat gtagtctgtt gacagccttc tttactgtgg actctgttcc tcaaccttga     5760

gtgcaggagg aatgcacatc tacttttgcc tttgtatcat tcctcctcac tcagctcttc     5820

acctccctgc agaccttaag aaatcagggg ccagctgcca agctgactct tttggttggt     5880

actatgttaa ctgaaaaggt gatttccgaa ggacaggttt tcttccctga tttctttgtt     5940

gctattaata gcaaaaacaa acttgcaaaa caacttcttt aacaaggaag ggaggatata     6000

tacaatgggt gatatggtaa tccaaccctg cttgacaaaa actgaagctg acaggttaca     6060

tttaaaaaca aaacaaaaca aaacgggaca gtttctgatt tgctttgtga caacaccatc     6120

tggcttatgt acaggagctc tcttagctgt tccttaaaca gaaaaaaaat cattactcct     6180

tttagttaaa tttggttaca ttttaatagt ttctttacat ctattctgaa gcaatttttg     6240

tcttctgtgg tacatggatt ttattataac attctaatat ttgtctttgt aaatactaga     6300

gactctttga tccatttctc taggaagttt ttcatcttat ggagttctga atcatgactt     6360

ttatctttat gaatgtatat gctttttact tgcaaaagcc aaaaagagtg aaacagcagt     6420

gcaattaaag caacaccaac taaactccaa atttccaagt gacaatatta gagaaaaaca     6480

gcatacacat ggctttatgc ctactgcttc tgcggtgggg tttgggtgcg caatggaaac     6540

tgtagcttgg ctgtgttctc ccacacaagt gaagaagaga ttggtttttg cttttttgga     6600

ttttgtgttt cttttctgtt ttgttttgtt ttgttttgtt ttgctttgct ttctttggcc     6660

atcaatgttc caactaatat gattggcgga gcacgtgctc tgctcagtag agtgaatgtt     6720

gctggtgcac tatgctcacc tgtgaacggc tggccatttc tccattcata tggttaagat     6780

ggaagatgag gatcacttac cagagaagtc aaggtgatca tctccaaaga ggtttacagt     6840

gcttggtagg aatggaaaat gaggacaaga aaaagaggag aaccatggag aaggcccaac     6900

tgggcaggac agcagccagc tgccaaagtc acgaactctg ggattcaaga agagtcgtgt     6960

agtgctttca actctcatcc gcaggcagct cactgtgtgt ggactctgag ctgacacggg     7020

agttggcttc tttgttccat agattttcta tgccacaggc aatattattg ttcttggaaa     7080

gttcattatt tttttaaatt accttactct cagaaaggga tttttttgaa ggattctgtc     7140

atatatcttt ggaaaacaga aaatcagtaa tatgtatatt tttatgtatg ttcactggca     7200

ctaaaaaaaa aaaaaaaaag aaaagaaaaa aaagagaaaa aaaaaagctt cactctgtcc     7260

tttgggtagt tgctgaggtt aattgtccag gttgagaaat gtgcttctgc taacatcctt     7320

ctctgtccac actctatttc taagtacata taggcatata taggaagata tattcaacac     7380

actttaagaa aaaagtatgt ccaccatcca catgataacc acaatgatac tccacaaatt     7440

acatgacttt aagcttcaag caacttctaa ctgattcatt catttatagc cttgccctct     7500

tctttccctt aaatttggcc cagcacaaag acccaagcca cccttatacc tccctaagac     7560

ttaagccagc accagacttc agaaggtttt ctgaagacaa ctgacttgct atccctgcat     7620

gaccctagca tggtcctgca aacacaagag actaattata attctcctcc actaattgcc     7680

tgggtcacag gtcattgggc caaggccatg attcttatgc ttacgaacca ctaatgctaa     7740

cctactagat taaatcctga actgaaagtt aaaagaagcc atttagcatg tgaaacttct     7800

tggagtaaga agtttctgtc ccggctgcct ttgcaaacag gtttgctttc accacttatc     7860

tccttgaaaa tctttgaagg cctttttttt ttaagtagaa aaggagatga aagcattata     7920

ttatgtaacc aaagattata ttgtatctaa gataccaaat tttttaaggg cagggaagga     7980

gcaagcatta gtgcctcttt ggtaaattat ccaaagacag actgaaggac ttttctgatg     8040

attgacttag aagactttgt ggggaggggt tgtctcacaa tatacatatt tagaagtgtt     8100

gagaataatt tggggggaaa tgggattata gtgtccttca ctaactgatt ttataagcag     8160

aactagcttt cctttttttt ttttttaaag tagttacaaa gcaaattctt aaagctccat     8220

ctttgcatgg ttagaaatgg agctggtctt ggccactgtg tttactagtg cccatgttag     8280

cttatttgaa gatgtgaagc ccttgataag aaggggtaca tttaaaggat tagatttttg     8340

cactagaagg agggcaggca gaaaccctca tttctgccca gtttggacag cacaaaaagt     8400

tctctgcagt ttaaggcaga aagttgaaat atattgtaaa tgagtatttg tatccatgtt     8460

tcaaaactga attctatata tagatgtaat gtgttctgat agctttacct ttctctgcac     8520

ctttatattt ggttccaggt catatctgat gccatgtact tgtaagagag gttgcagtta     8580

catttttgga tgctctctca gaatggataa gacacctgga ttgatcagat aactgagatc     8640

tcttcccttc ttgggcctgg tgttgaggcc ttgcaaaggg gtggaagagg aaagggtagg     8700

gtacatgatg tattgcactt tactagctta agacggatga atgtggaaag ggtggtgaaa     8760

tttcattgaa aatgcctagg aattgcaata gggagaaatc cagatgtggg gccaggtgcc     8820

cacccaaagg actggccagc agcctcttca tgggatctga ggcattggga aaaggaaggc     8880

tatttccttg gttttcacca tccttgttag agaagggcag ttgcctggtc ttgggaacct     8940

ggagcaaacg ctccttctgt cacatcaatt ctttcccctg caattgaggt gctcttgcta     9000

ctgggtgtcc gtgtgctcta attctggttc tggatatgtt ctgtaaagat tttgataatt     9060

gctaatgtat ttttctctgt taaaaatttg ttagtgtgtt agaagtcata tctctgtagg     9120

tacagatcct ttgctaccca tgagtagagg gatttttttt cttcaattaa gagtttgacc     9180

ctggggtctg ttgcccagag cccatccaga aaaaaaaatc cacatttgtc acaatttttc     9240

tgaaatttca gtcaaggtaa cagatcgctg ggagttctct ttaccccccc aaaaaagcag     9300

ataattgaat ttagcaggtg gtgttttaga gcaaaaaaca aaacagcctt tgacccagct     9360

ttaatatgac ccaatttaat ctggccagga agcaggtaat gtgtattaat tggcttccaa     9420

tcctggttga gtgtagcaag gttctacttt gtttcctagt tccttttgtt acatggcctt     9480

tcacagaaag gattgactgg gtttgcagta tatcttatgg ccttagcacc tattgctaac     9540

tgtcctgaag ggaattgcct atggggttgt cctataagcc acttctatca ttaaaagcag     9600

ccaccaatgg aatctcccag gtttgaaaaa aaaaaaaaaa aacagatggt cctttaccat     9660

tcattgacac acatccctgc tttcctgtag acagattgac tggacattga ttagggaata     9720

catggcaaat gacatgctta cactaccctg gagattaatt tggcagtagg agggaataga     9780

caatgtaacc aagaatgtaa tgtaattctt atagagataa gaattaaatc tggatgtgga     9840

gagagcaaag agagaaagca ttcaattttt ttttcaaaag aaaccaattt attttgcttg     9900

aaacttcttt cgctggggct tcagttctca cagcggctct tggtctccac tgggcagcag     9960

gaccagcccc aagcgctagt gttctgttct ctttttgtaa tcttggaatc ttttgttgct    10020

ctaaatacaa ttaaaaatgg cagaaacttg tttgttggaa tac                      10063