                         SEQUENCE LISTING

<110>  Aulos Bioscience, Inc
       AMIT, Inbar
       LEVIN, Itay
       NIMROD, Guy
       FISCHMAN, Sharon
       BARAK FUCHS, Reut
       STRAJBL, Marek
       WYANT, Timothy
       ZHENIN, Michael
       BLUVSHTEIN YERMOLAEV, Olga
       SASSON, Yehezkel
       GROSSMAN, Noam
       LEVITIN, Natalia
       OFRAN, Yanay
 
<120>  ENGINEERED ANTI-IL-2 ANTIBODIES

<130>  P-593094-PC

<150>  62/977,292
<151>  2020-02-16

<150>  63/139,315
<151>  2021-01-20

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.021

<400>  1
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gataacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgttctctg      300

gattccacct atatttaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact accagagccc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  2
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.022

<400>  2
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gattacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgttctctg      300

gattccacct ggatttaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact acattacccc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  3
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.023

<400>  3
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gattacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgtcagctg      300

gattccacct atatttaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact acattacccc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  4
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.030

<400>  4
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gattacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgttctctg      300

gattccacct atgactaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact acatttcgcc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  5
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.035

<400>  5
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gattacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgttctctg      300

gattccacct ataactaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact ggattagccc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of JES6.1

<400>  6

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Tyr Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of JES6.1

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Ser Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of JES6.1RMC

<400>  8

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Tyr Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of JES6.1RMC

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Ser Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.021

<400>  10

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Asn 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Tyr Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.021

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Gln Ser Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.022

<400>  12

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Trp Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.022

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.023

<400>  14

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Leu Asp Ser Thr Tyr Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.023

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.030

<400>  16

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Tyr Asp Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.030

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Ser Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.035

<400>  18

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.035

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Trp Ile Ser Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.038

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Ser 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Tyr Pro Ile Asp Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.038

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Asn 
            20                  25                  30          


Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Val Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.043

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Val Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Pro Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.043

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Asn 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Val Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  24
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.053

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Pro Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.053

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Asn 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  26
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.054

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Asp 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Trp Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.054

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Arg 
            20                  25                  30          


Gly Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


Ser Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  28
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.002

<400>  28
gagattcagc tgcagcagag cggtccagaa ctgcgtcgtc caggctcctc cgttaaactg       60

agctgcaaag cctctggtta taacatcacc gattacctga ttcattgggt tcgtcaccgt      120

ccagaacacg gtctggaatg gatcggctgg attgatccag aggacggtga aacccgttac      180

gcccaaaaat tccagtctaa agcaaccctg actgccgaca ctagctccaa cgccgcttac      240

atgcagctga gcagcctgac ccctgaggat accgccacct atttctgcgc acgttctctg      300

gattccaccc cgatttaccc attcgcatac tggggccaag gcacccttgt caccgtttcc      360

tccggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga cattgttatg      420

actcagtccc cattctccct ggccgtttct gagggtgaaa tggtaaccat taactgcaaa      480

tcatcccagt ccctgctgcg gtctggcaac cagaaaaact atctggcctg gtaccagcag      540

aaaccaggtc agtccccaaa actgctgatc tactacgcat ctactggcca gtctggtgtc      600

ccagaccgtt tcattggctc tggctctggt accgatttca ccctgaccat cagcgatgtt      660

caagctgaag acctggccga ttactattgt ctgcagcact acattacgcc accaactttc      720

ggtgcaggca ccaaactgga actgaaa                                          747


<210>  29
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.002

<400>  29

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg His Arg Pro Glu His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Pro Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.002

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Phe Ser Leu Ala Val Ser Glu Gly 
1               5                   10                  15      


Glu Met Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asp Val Gln Ala Glu Asp Leu Ala Asp Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  31
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.014

<400>  31
caggtccaac tggtgcagtc cggtgccgaa gttaaaaaac ctgggtcttc cgttaaagtt       60

tcttgcaaag cctctggcta cagcatcacc gattatctga ttcactgggt ccgtcaggct      120

ccaggtcaag gtctggaatg gatgggttgg atcgatccag aagacggtga aaccaactat      180

gcccagaaat tccagggtcg tgtaaccctg accgccgaca cctccacctc taccgcctac      240

atggagttaa gtagcctgcg ttcagaggat accgcagtgt actactgcgc tcgttcactg      300

gactccaccc caatctaccc attcgcatac tggggtcagg gcaccctggt aaccgttagt      360

agcggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga catcgtgatg      420

acccagtctc ctgactcctt ggccgtctct ctgggcgaac gtgcaactat caactgcaaa      480

tccagccaga gcttactgcg ttctggtaat cagaaaaact accttgcatg gtatcagcag      540

aaaccaggtc agccaccaaa attactgatc tattatgcat ctaccggtca aagcggtgtc      600

ccagatcgtt tcagcggttc cggctccggt actgacttca ccctgaccat ctcttccctt      660

caggccgaag atgtggccgt gtattactgc ctgcagcact acatcacccc acctactttc      720

ggtgctggta ctaaagttga aatcaaa                                          747


<210>  32
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.038

<400>  32
caggtccaac tggtgcagtc cggtgccgaa gttaaaaaac ctgggtcttc cgttaaagtt       60

tcttgcaaag cctctggcta cagcatcacc gattctctga ttcactgggt ccgtcaggct      120

ccaggtcaag gtctggaatg gatgggttgg atcgatccag aagacggtga aattaactat      180

gcccagaaat tccagggtcg tgtaaccctg accgccgaca cctccacctc taccgcctac      240

atggagttaa gtagcctgcg ttcagaggat accgcagtgt actactgcgc tcgttcactg      300

gactcctacc caatcgatcc attcgcatac tggggtcagg gcaccctggt aaccgttagt      360

agcggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga catcgtgatg      420

acccagtctc ctgactcctt ggccgtctct ctgggcgaac gtgcaactat caactgcaaa      480

tccagccaga gcttactgcg taatggtaat cagcaaaact accttgcatg gtatcagcag      540

aaaccaggtc agccaccaaa attactgatc tattatgcat ctaccggtca aagcggtgtc      600

ccagatcgtt tcagcggttc cggctccggt actgacttca ccctgaccat ctcttccctt      660

caggccgaag atgtggccgt gtattactgc cagcagcact acgtcacccc acctactttc      720

ggtgctggta ctaaagttga aatcaaa                                          747


<210>  33
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.043

<400>  33
caggtccaac tggtgcagtc cggtgccgaa gttaaaaaac ctgggtcttc cgttaaagtt       60

tcttgcaaag cctctggcta cagcatcacc gattatctga ttcactgggt ccgtcaggct      120

ccaggtcaag gtctggaatg gatgggttgg atcgatccag aagacggtgt gaccgcctat      180

gcccagaaat tccagggtcg tgtaaccctg accgccgaca cctccacctc taccgcctac      240

atggagttaa gtagcctgcg ttcagaggat accgcagtgt actactgcgc tcgttcactg      300

gactacgacc caatctaccc attcgcatac tggggtcagg gcaccctggt aaccgttagt      360

agcggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga catcgtgatg      420

acccagtctc ctgactcctt ggccgtctct ctgggcgaac gtgcaactat caactgcaaa      480

tccagccaga gcttactgcg taacggtaat cagaaaaact atcttgcatg gtatcagcag      540

aaaccaggtc agccaccaaa attactgatc tattatgcat ctaccggtca aagcggtgtc      600

ccagatcgtt tcagcggttc cggctccggt actgacttca ccctgaccat ctcttccctt      660

caggccgaag atgtggccgt gtattactgc cagcagcact acgtcacccc acctactttc      720

ggtgctggta ctaaagttga aatcaaa                                          747


<210>  34
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.053


<220>
<221>  misc_feature
<222>  (726)..(726)
<223>  n is a, c, g, or t

<400>  34
caggtccaac tggtgcagtc cggtgccgaa gttaaaaaac ctgggtcttc cgttaaagtt       60

tcttgcaaag cctctggcta cagcatcacc gattatctga ttcactgggt ccgtcaggct      120

ccaggtcaag gtctggaatg gatgggttgg atcgatccag aagacggtga aactaactat      180

gcccagaaat tccagggtcg tgtaaccctg accgccgaca cctccacctc taccgcctac      240

atggagttaa gtagcctgcg ttcagaggat accgcagtgt actactgcgc tcgttcactg      300

gactacgacc caatctaccc attcgcatac tggggtcagg gcaccctggt aaccgttagt      360

agcggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga catcgtgatg      420

acccagtctc ctgactcctt ggccgtctct ctgggcgaac gtgcaactat caactgcaaa      480

tccagccaga gcttactgcg taacggtaat cagaaaaact accttgcatg gtatcagcag      540

aaaccaggtc agccaccaaa attactgatc tattatgcat ctaccggtca aagcggtgtc      600

ccagatcgtt tcagcggttc cggctccggt actgacttca ccctgaccat ctcttccctt      660

caggccgaag atgtggccgt gtattactgc cagcagcact acattacccc acctactttc      720

ggtgcnggta ctaaagttga aatcaaa                                          747


<210>  35
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv clone 17.054

<400>  35
caggtccaac tggtgcagtc cggtgccgaa gttaaaaaac ctgggtcttc cgttaaagtt       60

tcttgcaaag cctctggcta cagcatcacc gatgacctga ttcactgggt ccgtcaggct      120

ccaggtcaag gtctggaatg gatgggttgg atcgatccag aagacggtga aaccaactat      180

gcccagaaat tccagggtcg tgtaaccctg accgccgaca cctccacctc taccgcctac      240

atggagttaa gtagcctgcg ttcagaggat accgcagtgt actactgcgc tcgttcactg      300

gactccacct ggatctaccc attcgcatac tggggtcagg gcaccctggt aaccgttagt      360

agcggcggtg gtggtagcgg aggcggagga tcaggtggag gcggcagtga catcgtgatg      420

acccagtctc ctgactcctt ggccgtctct ctgggcgaac gtgcaactat caactgcaaa      480

tccagccaga gcttactgcg tcgcggtaat cagaaaaacc accttgcatg gtatcagcag      540

aaaccaggtc agccaccaaa attactgatc tatgacgcat ctaccggtca aagcggtgtc      600

ccagatcgtt tcagcggttc cggctccggt actgacttca ccctgaccat ctcttccctt      660

caggccgaag atgtggccgt gtattactgc ctgcagagct acatcacccc acctactttc      720

ggtgctggta ctaaagttga aatcaaa                                          747


<210>  36
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region of clone 17.014

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Pro Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region of clone 17.014

<400>  37

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


His Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 H- CDR1

<400>  38

Gly Tyr Ser Ile Thr Asp Tyr Leu 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 H- CDR2

<400>  39

Ile Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 H- CDR3

<400>  40

Ala Arg Ser Leu Asp Ser Thr Pro Ile Tyr Pro Phe Ala Tyr 
1               5                   10                  


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 L- CDR1

<400>  41

Gln Ser Leu Leu Arg Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  42
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 L- CDR2

<400>  42

Tyr Ala Ser 
1           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.014 L- CDR3

<400>  43

Leu Gln His Tyr Ile Thr Pro Pro Thr 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 H- CDR1

<400>  44

Gly Tyr Ser Ile Thr Asp Ser Leu 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 H- CDR2

<400>  45

Ile Asp Pro Glu Asp Gly Glu Ile 
1               5               


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 H- CDR3

<400>  46

Ala Arg Ser Leu Asp Ser Tyr Pro Ile Asp Pro Phe Ala Tyr 
1               5                   10                  


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 L- CDR1

<400>  47

Gln Ser Leu Leu Arg Asn Gly Asn Gln Gln Asn Tyr 
1               5                   10          


<210>  48
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 L- CDR2

<400>  48

Tyr Ala Ser 
1           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.038 L- CDR3

<400>  49

Gln Gln His Tyr Val Thr Pro Pro Thr 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 H- CDR1

<400>  50

Gly Tyr Ser Ile Thr Asp Tyr Leu 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 H- CDR2

<400>  51

Ile Asp Pro Glu Asp Gly Val Thr 
1               5               


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 H- CDR3

<400>  52

Ala Arg Ser Leu Asp Tyr Asp Pro Ile Tyr Pro Phe Ala Tyr 
1               5                   10                  


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 L- CDR1

<400>  53

Gln Ser Leu Leu Arg Asn Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  54
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 L- CDR2

<400>  54

Tyr Ala Ser 
1           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.043 L- CDR3

<400>  55

Gln Gln His Tyr Val Thr Pro Pro Thr 
1               5                   


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 H- CDR1

<400>  56

Gly Tyr Ser Ile Thr Asp Tyr Leu 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 H- CDR2

<400>  57

Ile Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 H- CDR3

<400>  58

Ala Arg Ser Leu Asp Tyr Asp Pro Ile Tyr Pro Phe Ala Tyr 
1               5                   10                  


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 L- CDR1

<400>  59

Gln Ser Leu Leu Arg Asn Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  60
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 L- CDR2

<400>  60

Tyr Ala Ser 
1           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.053 L- CDR3

<400>  61

Gln Gln His Tyr Ile Thr Pro Pro Thr 
1               5                   


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 H- CDR1

<400>  62

Gly Tyr Ser Ile Thr Asp Asp Leu 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 H- CDR2

<400>  63

Ile Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 H- CDR3

<400>  64

Ala Arg Ser Leu Asp Ser Thr Trp Ile Tyr Pro Phe Ala Tyr 
1               5                   10                  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 L- CDR1

<400>  65

Gln Ser Leu Leu Arg Arg Gly Asn Gln Lys Asn His 
1               5                   10          


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 L- CDR2

<400>  66

Asp Ala Ser 
1           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17.054 L- CDR3

<400>  67

Leu Gln Ser Tyr Ile Thr Pro Pro Thr 
1               5                   


<210>  68
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.066 heavy Chain LALA

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Ser 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Tyr Pro Ile Asp Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  69
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.066 Light Chain

<400>  69

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Asn 
            20                  25                  30          


Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Val Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  70
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.067 heavy Chain LALA

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Tyr 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Val Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Tyr Asp Pro Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  71
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.067 Light Chain

<400>  71

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Asn 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Val Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  72
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.069 heavy Chain LALA

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Asp 
            20                  25                  30          


Leu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asp Ser Thr Trp Ile Tyr Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  73
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BDG17.069 Light Chain

<400>  73

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Arg Arg 
            20                  25                  30          


Gly Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Gly Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


Ser Tyr Ile Thr Pro Pro Thr Phe Gly Ala Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


