                         SEQUENCE LISTING

<110>  Adaptimmune Ltd
 
<120>  Method of treatment of cancer or tumour"

<130>  PC10113

<150>  US62/976,493
<151>  2020-02-14

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  1

Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  2
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  2

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  3
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  3

Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly 
1               5                   10                  15      


Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln 
        35                  40                  45              


Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe 
    50                  55                  60                  


Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly 
                85                  90                  95      


Gly Glu Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp 
        


<210>  4
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  4

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  5
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  5

Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly 
1               5                   10                  15      


Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln 
        35                  40                  45              


Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe 
    50                  55                  60                  


Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly 
                85                  90                  95      


Gly Glu Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp 
        


<210>  6
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  6

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ala 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  7
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  7

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Ser 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  8
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  8

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Val Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  9
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  9

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ala 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Val Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  10
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  10

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  11
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  11

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Tyr Ser Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  12
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  12

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Ser 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  13
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  13

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ala 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  14
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  14

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Val Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  15
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  15

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Asn Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  16
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  16

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Phe Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  17
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  17

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Tyr Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  18
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  18

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Tyr Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Ser 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  19
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  19

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Tyr Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Asp Ser Gly 
                85                  90                  95      


Val Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  20
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  20

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Tyr Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  21
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  21

Cys Ala Ala Ala Ala Ala Gly Ala Ala Gly Thr Thr Gly Ala Gly Cys 
1               5                   10                  15      


Ala Gly Ala Ala Thr Thr Cys Thr Gly Gly Ala Cys Cys Cys Cys Thr 
            20                  25                  30          


Cys Ala Gly Thr Gly Thr Thr Cys Cys Ala Gly Ala Gly Gly Gly Ala 
        35                  40                  45              


Gly Cys Cys Ala Thr Thr Gly Cys Cys Thr Cys Thr Cys Thr Cys Ala 
    50                  55                  60                  


Ala Cys Thr Gly Cys Ala Cys Thr Thr Ala Cys Ala Gly Thr Gly Ala 
65                  70                  75                  80  


Cys Cys Gly Ala Gly Gly Thr Thr Cys Cys Cys Ala Gly Thr Cys Cys 
                85                  90                  95      


Thr Thr Cys Thr Thr Cys Thr Gly Gly Thr Ala Cys Ala Gly Ala Cys 
            100                 105                 110         


Ala Ala Thr Ala Thr Thr Cys Thr Gly Gly Gly Ala Ala Ala Ala Gly 
        115                 120                 125             


Cys Cys Cys Thr Gly Ala Gly Thr Thr Gly Ala Thr Ala Ala Thr Gly 
    130                 135                 140                 


Thr Cys Cys Ala Thr Ala Thr Ala Cys Thr Cys Cys Ala Ala Thr Gly 
145                 150                 155                 160 


Gly Thr Gly Ala Cys Ala Ala Ala Gly Ala Ala Gly Ala Thr Gly Gly 
                165                 170                 175     


Ala Ala Gly Gly Thr Thr Thr Ala Cys Ala Gly Cys Ala Cys Ala Gly 
            180                 185                 190         


Cys Thr Cys Ala Ala Thr Ala Ala Ala Gly Cys Cys Ala Gly Cys Cys 
        195                 200                 205             


Ala Gly Thr Ala Thr Gly Thr Thr Thr Cys Thr Cys Thr Gly Cys Thr 
    210                 215                 220                 


Cys Ala Thr Cys Ala Gly Ala Gly Ala Cys Thr Cys Cys Cys Ala Gly 
225                 230                 235                 240 


Cys Cys Cys Ala Gly Thr Gly Ala Thr Thr Cys Ala Gly Cys Cys Ala 
                245                 250                 255     


Cys Cys Thr Ala Cys Cys Thr Cys Thr Gly Thr Gly Cys Cys Gly Thr 
            260                 265                 270         


Gly Ala Ala Thr Ala Gly Thr Gly Ala Thr Thr Cys Cys Gly Gly Gly 
        275                 280                 285             


Thr Ala Thr Gly Cys Ala Cys Thr Cys Ala Ala Cys Thr Thr Cys Gly 
    290                 295                 300                 


Gly Cys Ala Ala Ala Gly Gly Cys Ala Cys Cys Thr Cys Gly Cys Thr 
305                 310                 315                 320 


Gly Thr Thr Gly Gly Thr Cys Ala Cys Ala Cys Cys Cys Cys Ala Thr 
                325                 330                 335     


Ala Thr Cys Cys Ala Gly Ala Ala Cys Cys Cys Thr Gly Ala Cys Cys 
            340                 345                 350         


Cys Thr Gly Cys Cys Gly Thr Gly Thr Ala Cys Cys Ala Gly Cys Thr 
        355                 360                 365             


Gly Ala Gly Ala Gly Ala Cys Thr Cys Thr Ala Ala Gly Thr Cys Gly 
    370                 375                 380                 


Ala Gly Thr Gly Ala Cys Ala Ala Gly Thr Cys Thr Gly Thr Cys Thr 
385                 390                 395                 400 


Gly Cys Cys Thr Ala Thr Thr Cys Ala Cys Cys Gly Ala Thr Thr Thr 
                405                 410                 415     


Thr Gly Ala Thr Thr Cys Thr Cys Ala Ala Ala Cys Ala Ala Ala Thr 
            420                 425                 430         


Gly Thr Gly Thr Cys Ala Cys Ala Ala Ala Gly Thr Ala Ala Gly Gly 
        435                 440                 445             


Ala Thr Thr Cys Thr Gly Ala Thr Gly Thr Gly Thr Ala Thr Ala Thr 
    450                 455                 460                 


Cys Ala Cys Ala Gly Ala Cys Ala Ala Ala Thr Gly Thr Gly Thr Gly 
465                 470                 475                 480 


Cys Thr Ala Gly Ala Cys Ala Thr Gly Ala Gly Gly Thr Cys Thr Ala 
                485                 490                 495     


Thr Gly Gly Ala Cys Thr Thr Cys Ala Ala Gly Ala Gly Cys Ala Ala 
            500                 505                 510         


Cys Ala Gly Thr Gly Cys Thr Gly Thr Gly Gly Cys Cys Thr Gly Gly 
        515                 520                 525             


Ala Gly Cys Ala Ala Cys Ala Ala Ala Thr Cys Thr Gly Ala Cys Thr 
    530                 535                 540                 


Thr Thr Gly Cys Ala Thr Gly Thr Gly Cys Ala Ala Ala Cys Gly Cys 
545                 550                 555                 560 


Cys Thr Thr Cys Ala Ala Cys Ala Ala Cys Ala Gly Cys Ala Thr Thr 
                565                 570                 575     


Ala Thr Thr Cys Cys Ala Gly Ala Ala Gly Ala Cys Ala Cys Cys Thr 
            580                 585                 590         


Thr Cys Thr Thr Cys Cys Cys Cys Ala Gly Cys Cys Cys Ala Gly Ala 
        595                 600                 605             


Ala Ala Gly Thr Thr Cys Cys 
    610                 615 


<210>  22
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  22
gattctggag tcacacaaac cccaaagcac ctgatcacag caactggaca gcgagtgacg       60

ctgagatgct cccctaggtc tggagacctc tctgtgtact ggtaccaaca gagcctggac      120

cagggcctcc agttcctcat tcagtattat aatggagaag agagagcaaa aggaaacatt      180

cttgaacgat tctccgcaca acagttccct gacttgcact ctgaactaaa cctgagctct      240

ctggagctgg gggactcagc tttgtatttc tgtgccagca gcctcggggg ggaatctgag      300

cagtacttcg ggccgggcac caggctcacg gtcacagagg acctgaaaaa cgtgttccca      360

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      420

ctggtgtgcc tggccaccgg tttctacccc gaccacgtgg agctgagctg gtgggtgaat      480

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      540

ctcaatgact ccagatacgc tctgagcagc cgcctgaggg tctcggccac cttctggcag      600

gacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      660

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga      720

gcagac                                                                 726


<210>  23
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  23
gctagccgcc accatgatga agtccctgcg ggtgctgctg gtcatcctgt ggctgcagct       60

gtcctgggtc tggtcccagc agaaagaggt ggagcagaac agcggccctc tgagcgtgcc      120

cgagggcgct atcgccagcc tgaactgcac ctacagcgac agaggcagcc agagcttctt      180

ctggtacaga cagtacagcg gcaagagccc cgagctgatc atgagcatct acagcaacgg      240

cgacaaagag gacggccggt tcaccgccca gctgaacaag gccagccagt acgtgtccct      300

gctgatccgg gacagccagc ccagcgacag cgccacctac ctgtgcgccg tgaacagcga      360

ctccggctac gccctgaact tcggcaaggg caccagcctg ctggtgacac cccacattca      420

gaaccccgac cccgccgtgt accagctgcg ggacagcaag agcagcgaca agagcgtgtg      480

cctgttcacc gacttcgaca gccagaccaa cgtgtcccag agcaaggaca gcgacgtgta      540

catcaccgac aagaccgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt      600

ggcctggtcc aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcatcatccc      660

cgaggacaca tttttcccaa gccccgagag cagctgcgac gtcaaactgg tggagaagtc      720

cttcgagaca gacaccaacc tgaacttcca gaacctgagc gtgatcggct tcagaatcct      780

gctgctgaag gtggccggct tcaatctgct gatgaccctg cggctgtggt ccagcggcag      840

cagagccaag agaagcggat ccggcgccac caacttcagc ctgctgaagc aggccggcga      900

cgtggaggaa aaccctggcc ctaggatggg cttccggctg ctgtgctgcg tggccttctg      960

cctgctggga gccggccctg tggatagcgg cgtgacccag acccccaagc acctgatcac     1020

cgccaccggc cagagagtga ccctgcgctg cagccctaga agcggcgacc tgtccgtgta     1080

ctggtatcag cagagcctgg accagggact gcagttcctc atccagtact acaacggcga     1140

ggaacgggcc aagggcaaca tcctggaaag attcagcgcc cagcagttcc ccgacctgca     1200

cagcgagctg aacctgagca gcctggaact gggcgactcc gccctgtact tctgcgccag     1260

cagcctgggc ggcgagagcg aacagtactt cggccctggc acccggctga cggtaaccga     1320

ggacctgaag aacgtgttcc ccccagaggt ggccgtgttc gagccctctg aggccgagat     1380

cagccacacc cagaaagcca ccctggtctg cctggccacc ggcttctacc ccgaccacgt     1440

ggaactgtct tggtgggtga acggcaaaga ggtgcacagc ggcgtcagca ccgaccctca     1500

gcccctgaaa gagcagcccg ccctgaacga cagccggtac tgcctgagca gcagactgcg     1560

ggtgtccgcc accttctggc agaacccccg gaaccacttc agatgccagg tgcagttcta     1620

cggcctgagc gagaacgacg agtggaccca ggaccgggcc aagcctgtga cccagatcgt     1680

gtctgccgaa gcatgggggc gcgccgattg cggcttcaca agcgagagct accagcaggg     1740

cgtgctgagc gccaccatcc tgtacgagat cctgctgggc aaggccaccc tgtacgccgt     1800

gctggtgtcc gctctggtgc tgatggccat ggtgaaacgg aaggacagcc ggggctaata     1860

agtcgac                                                               1867


<210>  24
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  24

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys 
    50                  55                  60                  


Ser Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu 
                85                  90                  95      


Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Val Asn Ser Asp Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser 
        115                 120                 125             


Leu Leu Val Thr Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
        275                 280                 285             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg 
    290                 295                 300                 


Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
305                 310                 315                 320 


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
                325                 330                 335     


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
            340                 345                 350         


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
        355                 360                 365             


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
    370                 375                 380                 


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
385                 390                 395                 400 


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
                405                 410                 415     


Ser Leu Gly Gly Glu Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
            420                 425                 430         


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
        435                 440                 445             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    450                 455                 460                 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
465                 470                 475                 480 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
                485                 490                 495     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
            500                 505                 510         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
        515                 520                 525             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    530                 535                 540                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
545                 550                 555                 560 


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
                565                 570                 575     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            580                 585                 590         


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
        595                 600                 605             


Arg Lys Asp Ser Arg Gly 
    610                 


<210>  25
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  25
gaattccata tgcaaaaaga agttgaacaa aattctggac ccctc                       45


<210>  26
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  26
ttgtcagtcg acttagagtc tctcagctgg tacacg                                 36


<210>  27
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  27
gaattccata tggattctgg agttacacaa accccaaagc acctg                       45


<210>  28
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  28
tagaaaccgg tggccaggca caccagtgtg gc                                     32


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  29

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  30

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  31

Ala Val Asn Ser Asp Ser Gly Tyr Ala Leu Asn Phe 
1               5                   10          


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  32

Ser Gly Asp Leu Ser 
1               5   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  33

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  34

Ala Ser Ser Leu Gly Gly Glu Ser Glu Gln Tyr 
1               5                   10      


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  35

Asp Arg Gly Ser Gln Ala 
1               5       


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  36

Ala Val Asn Ser Asp Ser Ser Tyr Ala Leu Asn Phe 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  37

Ala Val Asn Ser Asp Ser Gly Val Ala Leu Asn Phe 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  38

Ala Val Asn Ser Gln Ser Gly Tyr Ala Leu Asn Phe 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  39

Ala Val Asn Ser Gln Ser Gly Tyr Ser Leu Asn Phe 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  40

Ala Val Asn Ser Gln Asn Gly Tyr Ala Leu Asn Phe 
1               5                   10          


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  41

Asp Arg Gly Ser Phe Ser 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  42

Asp Arg Gly Ser Tyr Ser 
1               5       


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  43

Ala Val Asn Ser Gln Ser Ser Tyr Ala Leu Asn Phe 
1               5                   10          


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Leu Leu Ser Asn Pro Thr Ser Gly 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Leu Leu Ser Asn Pro Thr Ser Gly 
1               5                   


<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Ser Asn Ser Ile Met 
1               5       


<210>  47
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  48
<211>  745
<212>  DNA
<213>  Homo sapiens

<400>  48
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag      120

ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg      180

cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg      240

gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc      300

accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac      360

tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      480

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      540

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      600

gttatcaccc tttactgcaa ccacaggaac cgaagacgtg tttgcaaatg tccccggcct      660

gtggtcaaat cgggagacaa gcccagcctt tcggcgagat acgtcggttc aagagctaaa      720

agaagtggta gtggtgcccc tgtga                                            745


<210>  49
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  49

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ala 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ser Gln Ser Gly 
                85                  90                  95      


Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205 


<210>  50
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  50

Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly 
1               5                   10                  15      


Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln 
        35                  40                  45              


Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe 
    50                  55                  60                  


Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly 
                85                  90                  95      


Gly Glu Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
            100                 105                 110         


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp 
        


<210>  51
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Lys Trp Val Glu Ser Ile Phe Leu Ile Phe Leu Leu Asn Phe Thr 
1               5                   10                  15      


Glu Ser Arg Thr Leu His Arg Asn Glu Tyr Gly Ile Ala Ser Ile Leu 
            20                  25                  30          


Asp Ser Tyr Gln Cys Thr Ala Glu Ile Ser Leu Ala Asp Leu Ala Thr 
        35                  40                  45              


Ile Phe Phe Ala Gln Phe Val Gln Glu Ala Thr Tyr Lys Glu Val Ser 
    50                  55                  60                  


Lys Met Val Lys Asp Ala Leu Thr Ala Ile Glu Lys Pro Thr Gly Asp 
65                  70                  75                  80  


Glu Gln Ser Ser Gly Cys Leu Glu Asn Gln Leu Pro Ala Phe Leu Glu 
                85                  90                  95      


Glu Leu Cys His Glu Lys Glu Ile Leu Glu Lys Tyr Gly His Ser Asp 
            100                 105                 110         


Cys Cys Ser Gln Ser Glu Glu Gly Arg His Asn Cys Phe Leu Ala His 
        115                 120                 125             


Lys Lys Pro Thr Pro Ala Ser Ile Pro Leu Phe Gln Val Pro Glu Pro 
    130                 135                 140                 


Val Thr Ser Cys Glu Ala Tyr Glu Glu Asp Arg Glu Thr Phe Met Asn 
145                 150                 155                 160 


Lys Phe Ile Tyr Glu Ile Ala Arg Arg His Pro Phe Leu Tyr Ala Pro 
                165                 170                 175     


Thr Ile Leu Leu Trp Ala Ala Arg Tyr Asp Lys Ile Ile Pro Ser Cys 
            180                 185                 190         


Cys Lys Ala Glu Asn Ala Val Glu Cys Phe Gln Thr Lys Ala Ala Thr 
        195                 200                 205             


Val Thr Lys Glu Leu Arg Glu Ser Ser Leu Leu Asn Gln His Ala Cys 
    210                 215                 220                 


Ala Val Met Lys Asn Phe Gly Thr Arg Thr Phe Gln Ala Ile Thr Val 
225                 230                 235                 240 


Thr Lys Leu Ser Gln Lys Phe Thr Lys Val Asn Phe Thr Glu Ile Gln 
                245                 250                 255     


Lys Leu Val Leu Asp Val Ala His Val His Glu His Cys Cys Arg Gly 
            260                 265                 270         


Asp Val Leu Asp Cys Leu Gln Asp Gly Glu Lys Ile Met Ser Tyr Ile 
        275                 280                 285             


Cys Ser Gln Gln Asp Thr Leu Ser Asn Lys Ile Thr Glu Cys Cys Lys 
    290                 295                 300                 


Leu Thr Thr Leu Glu Arg Gly Gln Cys Ile Ile His Ala Glu Asn Asp 
305                 310                 315                 320 


Glu Lys Pro Glu Gly Leu Ser Pro Asn Leu Asn Arg Phe Leu Gly Asp 
                325                 330                 335     


Arg Asp Phe Asn Gln Phe Ser Ser Gly Glu Lys Asn Ile Phe Leu Ala 
            340                 345                 350         


Ser Phe Val His Glu Tyr Ser Arg Arg His Pro Gln Leu Ala Val Ser 
        355                 360                 365             


Val Ile Leu Arg Val Ala Lys Gly Tyr Gln Glu Leu Leu Glu Lys Cys 
    370                 375                 380                 


Phe Gln Thr Glu Asn Pro Leu Glu Cys Gln Asp Lys Gly Glu Glu Glu 
385                 390                 395                 400 


Leu Gln Lys Tyr Ile Gln Glu Ser Gln Ala Leu Ala Lys Arg Ser Cys 
                405                 410                 415     


Gly Leu Phe Gln Lys Leu Gly Glu Tyr Tyr Leu Gln Asn Ala Phe Leu 
            420                 425                 430         


Val Ala Tyr Thr Lys Lys Ala Pro Gln Leu Thr Ser Ser Glu Leu Met 
        435                 440                 445             


Ala Ile Thr Arg Lys Met Ala Ala Thr Ala Ala Thr Cys Cys Gln Leu 
    450                 455                 460                 


Ser Glu Asp Lys Leu Leu Ala Cys Gly Glu Gly Ala Ala Asp Ile Ile 
465                 470                 475                 480 


Ile Gly His Leu Cys Ile Arg His Glu Met Thr Pro Val Asn Pro Gly 
                485                 490                 495     


Val Gly Gln Cys Cys Thr Ser Ser Tyr Ala Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ser Leu Val Val Asp Glu Thr Tyr Val Pro Pro Ala Phe Ser Asp 
        515                 520                 525             


Asp Lys Phe Ile Phe His Lys Asp Leu Cys Gln Ala Gln Gly Val Ala 
    530                 535                 540                 


Leu Gln Thr Met Lys Gln Glu Phe Leu Ile Asn Leu Val Lys Gln Lys 
545                 550                 555                 560 


Pro Gln Ile Thr Glu Glu Gln Leu Glu Ala Val Ile Ala Asp Phe Ser 
                565                 570                 575     


Gly Leu Leu Glu Lys Cys Cys Gln Gly Gln Glu Gln Glu Val Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Gln Lys Leu Ile Ser Lys Thr Arg Ala Ala Leu Gly 
        595                 600                 605             


Val 
    


