                         SEQUENCE LISTING

<110>  ETH Zurich
 
<120>  NANOPARTICLES ENCAPSULATING SMALL MOLECULES

<130>  P5798PC00

<150>  EP20157250.0
<151>  2020-02-13

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (58)..(58)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (66)..(66)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (92)..(92)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  At least 3 of the X amino acids at positions 11, 39, 66, 103,, 
       130, and 163  are independently of each other a positively 
       charged amino acid.

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  Any amino acid

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  Any amino acid

<400>  1

Met Xaa Gln Ala Ile Gly Ile Leu Glu Leu Xaa Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Xaa Val Xaa Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Xaa Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Xaa Ala Ile Xaa Xaa Ala Ile Xaa Thr Gly Thr Xaa Gln Ala 
    50                  55                  60                  


Gly Xaa Leu Leu Val Asp Ser Leu Val Leu Ala Xaa Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Xaa Gly Xaa Asn Xaa Val Xaa Xaa Xaa Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Xaa Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Xaa Ala Val Xaa Gly Ser Xaa Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Xaa Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Xaa Leu Val Tyr Ala Ser Leu Ile Pro Xaa Pro His Xaa Ala 
                165                 170                 175     


Met Trp Xaa Gln Met Val Xaa Gly Xaa Glu 
            180                 185     


<210>  2
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  3
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu Gly Ser 
            180                 185             


<210>  4
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Cys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  5
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Cys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr Leu Pro Met 
        195                 200                 205             


Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala 
    210                 215                 220                 


Ser Ala Arg Ile Asn Val 
225                 230 


<210>  6
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  7
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  8
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  9
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  10
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  11
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His 
            180                 185                 190     


<210>  12
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  13
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  14
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  15
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  16
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Leu Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17

Glu Phe Pro Pro Glu Val Glu Glu Gln Asp Asp Gly Thr Leu Pro Met 
1               5                   10                  15      


Ser Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala 
            20                  25                  30          


Ser Ala Arg Ile Asn Val 
        35              


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  18
ttaattaaag acttcaagcg g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19
gcttgaagtc tttaattaat t                                                 21


<210>  20
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His 
            180                 185                 


<210>  21
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  21

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


His His His 
        195 


<210>  22
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  22

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Cys Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


<210>  23
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  23

Met Gly Ala Arg Ala Ser Gly Ser Gly Ser Ser Gln Ala Ile Gly Ile 
1               5                   10                  15      


Leu Glu Leu Arg Ser Ile Ala Ala Gly Met Glu Leu Gly Asp Ala Met 
            20                  25                  30          


Leu Lys Ser Ala Asn Val Asp Leu Leu Val Ser Lys Thr Ile Ser Arg 
        35                  40                  45              


Gly Lys Phe Leu Leu Met Leu Gly Gly Asp Ile Gly Ala Ile Gln Gln 
    50                  55                  60                  


Ala Ile Glu Thr Gly Thr Ser Gln Ala Gly Arg Leu Leu Val Asp Ser 
65                  70                  75                  80  


Leu Val Leu Ala Asn Ile His Pro Ser Val Leu Pro Ala Ile Ser Gly 
                85                  90                  95      


Leu Asn Ser Val Asp Lys Arg Gln Ala Ile Gly Ile Leu Glu Thr Arg 
            100                 105                 110         


Ser Val Ala Ala Cys Ile Ser Ala Ala Asp Arg Ala Val Lys Gly Ser 
        115                 120                 125             


Asn Val Thr Leu Val Arg Val His Met Ala Arg Gly Ile Gly Gly Lys 
    130                 135                 140                 


Cys Tyr Met Val Val Ala Gly Asp Val Ser Asp Val Ala Leu Ala Val 
145                 150                 155                 160 


Thr Val Ala Ser Ser Ser Ala Gly Ala Tyr Gly Arg Leu Val Tyr Ala 
                165                 170                 175     


Ser Leu Ile Pro Arg Pro His Glu Ala Met Trp Arg Gln Met Val Glu 
            180                 185                 190         


Gly Leu Glu His His His His His His 
        195                 200     


<210>  24
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  24

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly 
        195                 200                 205             


Glu Ser Ser Thr Ala Pro Gly Lys Leu Val Gln Ser Pro Lys Gly Lys 
    210                 215                 220                 


Ala 
225 


<210>  25
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  25

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Gly Ser Gly Ser Gly Gly Val Asp Asn Lys Phe Asn Lys Glu 
        195                 200                 205             


Met Arg Asn Ala Tyr Trp Glu Ile Ala Leu Leu Pro Asn Leu Asn Asn 
    210                 215                 220                 


Gln Gln Lys Arg Ala Phe Ile Arg Ser Leu Tyr Asp Asp Pro Ser Gln 
225                 230                 235                 240 


Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala 
                245                 250                 255     


Pro Lys 
        


<210>  26
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Gly Ser Gly Ser Gly Gly Val Asp Asn Lys Phe Asn Lys Glu 
        195                 200                 205             


Met Trp Ala Ala Trp Glu Glu Ile Arg Asn Leu Pro Asn Leu Asn Gly 
    210                 215                 220                 


Trp Gln Met Thr Ala Phe Ile Ala Ser Leu Val Asp Asp Pro Ser Gln 
225                 230                 235                 240 


Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala 
                245                 250                 255     


Pro Lys 
        


<210>  27
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Arg Ser Ile Ala Ala Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Arg Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Arg Leu Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Arg Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Arg Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Arg Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Ser Asp Val Ala Leu Ala Val Thr Val Ala Ser Ser Ser Ala Gly Ala 
145                 150                 155                 160 


Tyr Gly Arg Leu Val Tyr Ala Ser Leu Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly Leu Glu His His His His His His 
            180                 185                 190         


Glu Phe Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser 
        195                 200                 205             


Phe Ser Ile Ile His Thr Pro Ile Leu Pro Leu 
    210                 215                 


