               SEQUENCE LISTING

<110> JANSSEN PHARMACEUTICA NV

<120> FGFR TYROSINE KINASE INHIBITORS AND ANTI-PD1 AGENTS FOR THE TREATMENT OF UROTHELIAL CARCINOMA

<130> PRD4068WOPCT1

<150> US63/083316
<151> 2020-09-25
<150> US63/078736
<151> 2020-09-15
<150> US63/078205
<151> 2020-09-14
<150> US63/055187
<151> 2020-07-22
<150> US63/025817
<151> 2020-05-15
<150> US62/975526
<151> 2020-02-12

<160> 49

<170> BiSSAP 1.3.6

<210> 1
<211> 268
<212> DNA
<213> Homo sapiens


<400> 1
tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg     60

tacacgctgg acgtgctgga gtgctccccg caccggccca tcctgcaggc ggggctgccg    120

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac    180

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg    240

gacggcacac cctacgttac cgtgctca                                       268


<210> 2
<211> 378
<212> DNA
<213> Homo sapiens


<400> 2
gaccgcggca actacacctg cgtcgtggag aacaagtttg gcagcatccg gcagacgtac      60

acgctggacg tgctgggtga gggccctggg gcggcgcggg ggtgggggcg gcagtggcgg     120

tggtggtgag ggagggggtg gcccctgagc gtcatctgcc cccacagagc gctgcccgca     180

ccggcccatc ctgcaggcgg ggctgccggc caaccagacg gcggtgctgg gcagcgacgt     240

ggagttccac tgcaaggtgt acagtgacgc acagccccac atccagtggc tcaagcacgt     300

ggaggtgaat ggcagcaagg tgggcccgga cggcacaccc tacgttaccg tgctcaaggt     360

gggccaccgt gtgcacgt                                                   378


<210> 3
<211> 234
<212> DNA
<213> Homo sapiens


<400> 3
gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag     60

gaggagctgg tggaggctga cgaggcgtgc agtgtgtatg caggcatcct cagctacggg    120

gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc    180

ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccg          234


<210> 4
<211> 301
<212> DNA
<213> Homo sapiens


<400> 4
ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg     60

gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag    120

gaggagctgg tggaggctga cgaggcgggc agtgtgtgtg caggcatcct cagctacggg    180

gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc    240

ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag    300

c                                                                    301


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 5
gacctggacc gtgtccttac c                                              21


<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 6
cttccccagt tccaggttct t                                              21


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 7
aggacctgga ccgtgtcctt                                                20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> synthetic primer

<400> 8
tataggtccg gtggacaggg                                                20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 9
ctggaccgtg tccttaccgt                                                20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 10
gcagcccagg attgaactgt                                                20


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 11
tggatcgaat tctcactctc aca                                            23


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 12
gccaagcaat ctgcgtattt g                                              21


<210> 13
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 13
gctcttcaat acagccctga tca                                            23


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 14
acttggatcg aattctcact ctca                                           24


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 15
tggatcgaat tctcactctc aca                                            23


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 16
gcaaagcctg aattttcttg aataa                                          25


<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 17
gcatccggca gacgtaca                                                  18


<210> 18
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 18
ccccgcctgc aggat                                                     15


<210> 19
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 19
gcatccggca gacgtaca                                                  18


<210> 20
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 20
ccccgcctgc aggat                                                     15


<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 21
aggagctggt ggaggctga                                                 19


<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 22
ccgtagctga ggatgcctg                                                 19


<210> 23
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 23
ctggtggagg ctgacgag                                                  18


<210> 24
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 24
agcccacccc gtagct                                                    16


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 25
gtcgtggaga acaagtttgg c                                              21


<210> 26
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 26
gtctggttgg ccggcag                                                   17


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 27
gtcgtggaga acaagtttgg c                                              21


<210> 28
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 28
gtctggttgg ccggcag                                                   17


<210> 29
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> synthetic primer

<400> 29
aggagctggt ggaggctga                                                 19


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 30
ccgtagctga ggatgcctg                                                 19


<210> 31
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 31
gacgaggcgg gcagtg                                                    16


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic primer

<400> 32
gaagaagccc accccgtag                                                 19


<210> 33
<211> 2850
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic polynucleotide

<400> 33
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc      60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc     120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc     180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg     240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc     300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac     360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag     420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac     480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc     540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc     600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc     660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg     720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg     780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac     840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg     900

gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag     960

ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg    1020

gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag    1080

gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg    1140

gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc    1200

ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag    1260

cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc    1320

gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct    1380

gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag    1440

ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc    1500

aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg    1560

gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac    1620

ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag    1680

ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac    1740

acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag    1800

gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc    1860

cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg    1920

gacgtgcaca acctcgacta ctacaagaag acgaccaacg gccggctgcc cgtgaagtgg    1980

atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt    2040

ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg    2100

gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca    2160

cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc    2220

ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgtaaag    2280

gcgacacagg aggagaaccg ggagctgagg agcaggtgtg aggagctcca cgggaagaac    2340

ctggaactgg ggaagatcat ggacaggttc gaagaggttg tgtaccaggc catggaggaa    2400

gttcagaagc agaaggaact ttccaaagct gaaatccaga aagttctaaa agaaaaagac    2460

caacttacca cagatctgaa ctccatggag aagtccttct ccgacctctt caagcgtttt    2520

gagaaacaga aagaggtgat cgagggctac cgcaagaacg aagagtcact gaagaagtgc    2580

gtggaggatt acctggcaag gatcacccag gagggccaga ggtaccaagc cctgaaggcc    2640

cacgcggagg agaagctgca gctggcaaac gaggagatcg cccaggtccg gagcaaggcc    2700

caggcggaag cgttggccct ccaggccagc ctgaggaagg agcagatgcg catccagtcg    2760

ctggagaaga cagtggagca gaagactaaa gagaacgagg agctgaccag gatctgcgac    2820

gacctcatct ccaagatgga gaagatctga                                     2850


<210> 34
<211> 2955
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic polynucleotide

<400> 34
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc      60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc     120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc     180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg     240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc     300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac     360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag     420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac     480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc     540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc     600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc     660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg     720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg     780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac     840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg     900

gacggcacac cctacgttac cgtgctcaag acggcgggcg ctaacaccac cgacaaggag     960

ctagaggttc tctccttgca caacgtcacc tttgaggacg ccggggagta cacctgcctg    1020

gcgggcaatt ctattgggtt ttctcatcac tctgcgtggc tggtggtgct gccagccgag    1080

gaggagctgg tggaggctga cgaggcgggc agtgtgtatg caggcatcct cagctacggg    1140

gtgggcttct tcctgttcat cctggtggtg gcggctgtga cgctctgccg cctgcgcagc    1200

ccccccaaga aaggcctggg ctcccccacc gtgcacaaga tctcccgctt cccgctcaag    1260

cgacaggtgt ccctggagtc caacgcgtcc atgagctcca acacaccact ggtgcgcatc    1320

gcaaggctgt cctcagggga gggccccacg ctggccaatg tctccgagct cgagctgcct    1380

gccgacccca aatgggagct gtctcgggcc cggctgaccc tgggcaagcc ccttggggag    1440

ggctgcttcg gccaggtggt catggcggag gccatcggca ttgacaagga ccgggccgcc    1500

aagcctgtca ccgtagccgt gaagatgctg aaagacgatg ccactgacaa ggacctgtcg    1560

gacctggtgt ctgagatgga gatgatgaag atgatcggga aacacaaaaa catcatcaac    1620

ctgctgggcg cctgcacgca gggcgggccc ctgtacgtgc tggtggagta cgcggccaag    1680

ggtaacctgc gggagtttct gcgggcgcgg cggcccccgg gcctggacta ctccttcgac    1740

acctgcaagc cgcccgagga gcagctcacc ttcaaggacc tggtgtcctg tgcctaccag    1800

gtggcccggg gcatggagta cttggcctcc cagaagtgca tccacaggga cctggctgcc    1860

cgcaatgtgc tggtgaccga ggacaacgtg atgaagatcg cagacttcgg gctggcccgg    1920

gacgtgcaca acctcgacta ctacaagaag acgaccaacg gccggctgcc cgtgaagtgg    1980

atggcgcctg aggccttgtt tgaccgagtc tacactcacc agagtgacgt ctggtccttt    2040

ggggtcctgc tctgggagat cttcacgctg gggggctccc cgtaccccgg catccctgtg    2100

gaggagctct tcaagctgct gaaggagggc caccgcatgg acaagcccgc caactgcaca    2160

cacgacctgt acatgatcat gcgggagtgc tggcatgccg cgccctccca gaggcccacc    2220

ttcaagcagc tggtggagga cctggaccgt gtccttaccg tgacgtccac cgacgtgcca    2280

ggcccacccc caggtgttcc cgcgcctggg ggcccacccc tgtccaccgg acctatagtg    2340

gacctgctcc agtacagcca gaaggacctg gatgcagtgg taaaggcgac acaggaggag    2400

aaccgggagc tgaggagcag gtgtgaggag ctccacggga agaacctgga actggggaag    2460

atcatggaca ggttcgaaga ggttgtgtac caggccatgg aggaagttca gaagcagaag    2520

gaactttcca aagctgaaat ccagaaagtt ctaaaagaaa aagaccaact taccacagat    2580

ctgaactcca tggagaagtc cttctccgac ctcttcaagc gttttgagaa acagaaagag    2640

gtgatcgagg gctaccgcaa gaacgaagag tcactgaaga agtgcgtgga ggattacctg    2700

gcaaggatca cccaggaggg ccagaggtac caagccctga aggcccacgc ggaggagaag    2760

ctgcagctgg caaacgagga gatcgcccag gtccggagca aggcccaggc ggaagcgttg    2820

gccctccagg ccagcctgag gaaggagcag atgcgcatcc agtcgctgga gaagacagtg    2880

gagcagaaga ctaaagagaa cgaggagctg accaggatct gcgacgacct catctccaag    2940

atggagaaga tctga                                                     2955


<210> 35
<211> 3765
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic polynucleotide

<400> 35
atgggcgccc ctgcctgcgc cctcgcgctc tgcgtggccg tggccatcgt ggccggcgcc       60

tcctcggagt ccttggggac ggagcagcgc gtcgtggggc gagcggcaga agtcccgggc      120

ccagagcccg gccagcagga gcagttggtc ttcggcagcg gggatgctgt ggagctgagc      180

tgtcccccgc ccgggggtgg tcccatgggg cccactgtct gggtcaagga tggcacaggg      240

ctggtgccct cggagcgtgt cctggtgggg ccccagcggc tgcaggtgct gaatgcctcc      300

cacgaggact ccggggccta cagctgccgg cagcggctca cgcagcgcgt actgtgccac      360

ttcagtgtgc gggtgacaga cgctccatcc tcgggagatg acgaagacgg ggaggacgag      420

gctgaggaca caggtgtgga cacaggggcc ccttactgga cacggcccga gcggatggac      480

aagaagctgc tggccgtgcc ggccgccaac accgtccgct tccgctgccc agccgctggc      540

aaccccactc cctccatctc ctggctgaag aacggcaggg agttccgcgg cgagcaccgc      600

attggaggca tcaagctgcg gcatcagcag tggagcctgg tcatggaaag cgtggtgccc      660

tcggaccgcg gcaactacac ctgcgtcgtg gagaacaagt ttggcagcat ccggcagacg      720

tacacgctgg acgtgctgga gcgctccccg caccggccca tcctgcaggc ggggctgccg      780

gccaaccaga cggcggtgct gggcagcgac gtggagttcc actgcaaggt gtacagtgac      840

gcacagcccc acatccagtg gctcaagcac gtggaggtga atggcagcaa ggtgggcccg      900

gacggcacac cctacgttac cgtgctcaag tcctggatca gtgagagtgt ggaggccgac      960

gtgcgcctcc gcctggccaa tgtgtcggag cgggacgggg gcgagtacct ctgtcgagcc     1020

accaatttca taggcgtggc cgagaaggcc ttttggctga gcgttcacgg gccccgagca     1080

gccgaggagg agctggtgga ggctgacgag gcgggcagtg tgtatgcagg catcctcagc     1140

tacggggtgg gcttcttcct gttcatcctg gtggtggcgg ctgtgacgct ctgccgcctg     1200

cgcagccccc ccaagaaagg cctgggctcc cccaccgtgc acaagatctc ccgcttcccg     1260

ctcaagcgac aggtgtccct ggagtccaac gcgtccatga gctccaacac accactggtg     1320

cgcatcgcaa ggctgtcctc aggggagggc cccacgctgg ccaatgtctc cgagctcgag     1380

ctgcctgccg accccaaatg ggagctgtct cgggcccggc tgaccctggg caagcccctt     1440

ggggagggct gcttcggcca ggtggtcatg gcggaggcca tcggcattga caaggaccgg     1500

gccgccaagc ctgtcaccgt agccgtgaag atgctgaaag acgatgccac tgacaaggac     1560

ctgtcggacc tggtgtctga gatggagatg atgaagatga tcgggaaaca caaaaacatc     1620

atcaacctgc tgggcgcctg cacgcagggc gggcccctgt acgtgctggt ggagtacgcg     1680

gccaagggta acctgcggga gtttctgcgg gcgcggcggc ccccgggcct ggactactcc     1740

ttcgacacct gcaagccgcc cgaggagcag ctcaccttca aggacctggt gtcctgtgcc     1800

taccaggtgg cccggggcat ggagtacttg gcctcccaga agtgcatcca cagggacctg     1860

gctgcccgca atgtgctggt gaccgaggac aacgtgatga agatcgcaga cttcgggctg     1920

gcccgggacg tgcacaacct cgactactac aagaagacga ccaacggccg gctgcccgtg     1980

aagtggatgg cgcctgaggc cttgtttgac cgagtctaca ctcaccagag tgacgtctgg     2040

tcctttgggg tcctgctctg ggagatcttc acgctggggg gctccccgta ccccggcatc     2100

cctgtggagg agctcttcaa gctgctgaag gagggccacc gcatggacaa gcccgccaac     2160

tgcacacacg acctgtacat gatcatgcgg gagtgctggc atgccgcgcc ctcccagagg     2220

cccaccttca agcagctggt ggaggacctg gaccgtgtcc ttaccgtgac gtccaccgac     2280

aatgttatgg aacagttcaa tcctgggctg cgaaatttaa taaacctggg gaaaaattat     2340

gagaaagctg taaacgctat gatcctggca ggaaaagcct actacgatgg agtggccaag     2400

atcggtgaga ttgccactgg gtcccccgtg tcaactgaac tgggacatgt cctcatagag     2460

atttcaagta cccacaagaa actcaacgag agtcttgatg aaaattttaa aaaattccac     2520

aaagagatta tccatgagct ggagaagaag atagaacttg acgtgaaata tatgaacgca     2580

actctaaaaa gataccaaac agaacacaag aataaattag agtctttgga gaaatcccaa     2640

gctgagttga agaagatcag aaggaaaagc caaggaagcc gaaacgcact caaatatgaa     2700

cacaaagaaa ttgagtatgt ggagaccgtt acttctcgtc agagtgaaat ccagaaattc     2760

attgcagatg gttgcaaaga ggctctgctt gaagagaaga ggcgcttctg ctttctggtt     2820

gataagcact gtggctttgc aaaccacata cattattatc acttacagtc tgcagaacta     2880

ctgaattcca agctgcctcg gtggcaggag acctgtgttg atgccatcaa agtgccagag     2940

aaaatcatga atatgatcga agaaataaag accccagcct ctacccccgt gtctggaact     3000

cctcaggctt cacccatgat cgagagaagc aatgtggtta ggaaagatta cgacaccctt     3060

tctaaatgct caccaaagat gccccccgct ccttcaggca gagcatatac cagtcccttg     3120

atcgatatgt ttaataaccc agccacggct gccccgaatt cacaaagggt aaataattca     3180

acaggtactt ccgaagatcc cagtttacag cgatcagttt cggttgcaac gggactgaac     3240

atgatgaaga agcagaaagt gaagaccatc ttcccgcaca ctgcgggctc caacaagacc     3300

ttactcagct ttgcacaggg agatgtcatc acgctgctca tccccgagga gaaggatggc     3360

tggctctatg gagaacacga cgtgtccaag gcgaggggtt ggttcccgtc gtcgtacacg     3420

aagttgctgg aagaaaatga gacagaagca gtgaccgtgc ccacgccaag ccccacacca     3480

gtgagaagca tcagcaccgt gaacttgtct gagaatagca gtgttgtcat ccccccaccc     3540

gactacttgg aatgcttgtc catgggggca gctgccgaca ggagagcaga ttcggccagg     3600

acgacatcca cctttaaggc cccagcgtcc aagcccgaga ccgcggctcc taacgatgcc     3660

aacgggactg caaagccgcc ttttctcagc ggagaaaacc cctttgccac tgtgaaactc     3720

cgcccgactg tgacgaatga tcgctcggca cccatcattc gatga                     3765


<210> 36
<211> 4989
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic polynucleotide

<400> 36
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg       60

gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc      120

aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg      180

cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg      240

cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga      300

gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc      360

atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg      420

gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa      480

aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca      540

gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag      600

gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt      660

gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg agaatgaata cgggtccatc      720

aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc      780

ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt      840

tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa      900

tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg      960

gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat     1020

acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg     1080

ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt     1140

tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg     1200

aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa     1260

cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc     1320

aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg     1380

gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag     1440

ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca     1500

gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa     1560

gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg     1620

attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc     1680

tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg     1740

ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc     1800

aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa     1860

aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg     1920

aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc     1980

accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac     2040

actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg     2100

ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac     2160

agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg     2220

catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt     2280

ctcactctca caaccaatga gatcatggag gaaacaaata cgcagattgc ttggccatca     2340

aaactgaaga tcggagccaa atccaagaaa gatccccata ttaaggtttc tggaaagaaa     2400

gaagatgtta aagaagccaa ggaaatgatc atgtctgtct tagacacaaa aagcaatcga     2460

gtcacactga agatggatgt ttcacataca gaacattcac atgtaatcgg caaaggtggc     2520

aacaatatta aaaaagtgat ggaagaaacc ggatgccata tccactttcc agattccaac     2580

aggaataacc aagcagaaaa aagcaaccag gtatctatag cgggacaacc agcaggagta     2640

gaatctgccc gagttagaat tcgggagctg cttcctttgg tgctgatgtt tgagctacca     2700

attgctggaa ttcttcaacc ggttcctgat cctaattccc cctctattca gcatatatca     2760

caaacgtaca atatttcagt atcatttaaa cagcgttccc gaatgtatgg tgctactgtc     2820

atagtacgag ggtctcagaa taacactagt gctgtgaagg aaggaactgc catgctgtta     2880

gaacatcttg ctgggagctt agcatcagct attcctgtga gcacacaact agatattgca     2940

gctcaacatc atctctttat gatgggtcga aatgggagca acatcaaaca tatcatgcag     3000

agaacaggtg ctcagatcca ctttcctgat cccagtaatc cacaaaagaa atctaccgtc     3060

tacctccagg gcaccattga gtctgtctgt cttgcaaggc aatatctcat gggttgtctt     3120

cctcttgtgt tgatgtttga tatgaaggaa gaaattgaag tagatccaca attcattgcg     3180

cagttgatgg aacagcttga tgtcttcatc agtattaaac caaagcccaa acagccaagc     3240

aagtctgtga ttgtgaaaag tgttgagcga aatgccttaa atatgtatga agcaaggaaa     3300

tgtctcctcg gacttgaaag cagtggggtt accatagcaa ccagtccatc cccagcatcc     3360

tgccctgccg gcctggcatg tcccagcctg gatatcttag cttcagcagg ccttggactc     3420

actggactag gtcttttggg acccaccacc ttatctctga acacttcaac aaccccaaac     3480

tcactcttga atgctcttaa tagctcagtc agtcctttgc aaagtccaag ttctggtaca     3540

cccagcccca cattatgggc acccccactt gctaatactt caagtgccac aggtttttct     3600

gctataccac accttatgat tccatctact gcccaagcca cattaactaa tattttgttg     3660

tctggagtgc ccacctatgg gcacacagct ccatctcccc ctcctggctt gactcctgtt     3720

gatgtccata tcaacagtat gcagaccgaa ggcaaaaaaa tctctgctgc tttaaatgga     3780

catgcacagt ctccagatat aaaatatggt gcaatatcca cttcatcact tggagaaaaa     3840

gtgctgagtg caaatcacgg ggatccgtcc atccagacaa gtgggtctga gcagacatct     3900

cccaaatcaa gccccactga aggttgtaat gatgcttttg ttgaagtagg catgcctcga     3960

agtccttccc attctgggaa tgctggtgac ttgaaacaga tgatgtgtcc ctccaaggtt     4020

tcctgtgcca aaaggcagac agtggaacta ttgcaaggca cgaaaaactc acacttacac     4080

agcactgaca ggttgctctc agaccctgaa ctgagtgcta ccgaaagccc tttggctgac     4140

aagaaggctc cagggagtga gcgcgctgca gagagggcag cagctgccca gcaaaactcc     4200

gaaagggccc accttgctcc acggtcatca tatgtcaaca tgcaggcatt tgactatgaa     4260

cagaagaagc tattagccac caaagctatg ttaaagaaac cagtggtgac ggaggtcaga     4320

acgcccacaa atacctggag tggcctgggt ttttctaaat ccatgccagc tgaaactatc     4380

aaggagttga gaagggccaa tcatgtgtcc tataagccca caatgacaac cacttatgag     4440

ggctcatcca tgtccctttc acggtccaac agtcgtgagc acttgggagg tggaagcgaa     4500

tctgataact ggagagaccg aaatggaatt ggacctggaa gtcatagtga atttgcagct     4560

tctattggca gccctaagcg taaacaaaac aaatcaacgg aacactatct cagcagtagc     4620

aattacatgg actgcatttc ctcgctgaca ggaagcaatg gctgtaactt aaatagctct     4680

ttcaaaggtt ctgacctccc tgagctcttc agcaaactgg gcctgggcaa atacacagat     4740

gttttccagc aacaagagat cgatcttcag acattcctca ctctcacaga tcaggatctg     4800

aaggagctgg gaataactac ttttggtgcc aggaggaaaa tgctgcttgc aatttcagaa     4860

ctaaataaaa accgaagaaa gctttttgaa tcgccaaatg cacgcacctc tttcctggaa     4920

ggtggagcga gtggaaggct accccgtcag tatcactcag acattgctag tgtcagtggc     4980

cgctggtag                                                             4989


<210> 37
<211> 3213
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic polynucleotide

<400> 37
atggtcagct ggggtcgttt catctgcctg gtcgtggtca ccatggcaac cttgtccctg       60

gcccggccct ccttcagttt agttgaggat accacattag agccagaaga gccaccaacc      120

aaataccaaa tctctcaacc agaagtgtac gtggctgcgc caggggagtc gctagaggtg      180

cgctgcctgt tgaaagatgc cgccgtgatc agttggacta aggatggggt gcacttgggg      240

cccaacaata ggacagtgct tattggggag tacttgcaga taaagggcgc cacgcctaga      300

gactccggcc tctatgcttg tactgccagt aggactgtag acagtgaaac ttggtacttc      360

atggtgaatg tcacagatgc catctcatcc ggagatgatg aggatgacac cgatggtgcg      420

gaagattttg tcagtgagaa cagtaacaac aagagagcac catactggac caacacagaa      480

aagatggaaa agcggctcca tgctgtgcct gcggccaaca ctgtcaagtt tcgctgccca      540

gccgggggga acccaatgcc aaccatgcgg tggctgaaaa acgggaagga gtttaagcag      600

gagcatcgca ttggaggcta caaggtacga aaccagcact ggagcctcat tatggaaagt      660

gtggtcccat ctgacaaggg aaattatacc tgtgtagtgg agaatgaata cgggtccatc      720

aatcacacgt accacctgga tgttgtggag cgatcgcctc accggcccat cctccaagcc      780

ggactgccgg caaatgcctc cacagtggtc ggaggagacg tagagtttgt ctgcaaggtt      840

tacagtgatg cccagcccca catccagtgg atcaagcacg tggaaaagaa cggcagtaaa      900

tacgggcccg acgggctgcc ctacctcaag gttctcaagg ccgccggtgt taacaccacg      960

gacaaagaga ttgaggttct ctatattcgg aatgtaactt ttgaggacgc tggggaatat     1020

acgtgcttgg cgggtaattc tattgggata tcctttcact ctgcatggtt gacagttctg     1080

ccagcgcctg gaagagaaaa ggagattaca gcttccccag actacctgga gatagccatt     1140

tactgcatag gggtcttctt aatcgcctgt atggtggtaa cagtcatcct gtgccgaatg     1200

aagaacacga ccaagaagcc agacttcagc agccagccgg ctgtgcacaa gctgaccaaa     1260

cgtatccccc tgcggagaca ggtaacagtt tcggctgagt ccagctcctc catgaactcc     1320

aacaccccgc tggtgaggat aacaacacgc ctctcttcaa cggcagacac ccccatgctg     1380

gcaggggtct ccgagtatga acttccagag gacccaaaat gggagtttcc aagagataag     1440

ctgacactgg gcaagcccct gggagaaggt tgctttgggc aagtggtcat ggcggaagca     1500

gtgggaattg acaaagacaa gcccaaggag gcggtcaccg tggccgtgaa gatgttgaaa     1560

gatgatgcca cagagaaaga cctttctgat ctggtgtcag agatggagat gatgaagatg     1620

attgggaaac acaagaatat cataaatctt cttggagcct gcacacagga tgggcctctc     1680

tatgtcatag ttgagtatgc ctctaaaggc aacctccgag aatacctccg agcccggagg     1740

ccacccggga tggagtactc ctatgacatt aaccgtgttc ctgaggagca gatgaccttc     1800

aaggacttgg tgtcatgcac ctaccagctg gccagaggca tggagtactt ggcttcccaa     1860

aaatgtattc atcgagattt agcagccaga aatgttttgg taacagaaaa caatgtgatg     1920

aaaatagcag actttggact cgccagagat atcaacaata tagactatta caaaaagacc     1980

accaatgggc ggcttccagt caagtggatg gctccagaag ccctgtttga tagagtatac     2040

actcatcaga gtgatgtctg gtccttcggg gtgttaatgt gggagatctt cactttaggg     2100

ggctcgccct acccagggat tcccgtggag gaacttttta agctgctgaa ggaaggacac     2160

agaatggata agccagccaa ctgcaccaac gaactgtaca tgatgatgag ggactgttgg     2220

catgcagtgc cctcccagag accaacgttc aagcagttgg tagaagactt ggatcgaatt     2280

ctcactctca caaccaatga gatggcagat gatcagggct gtattgaaga gcagggggtt     2340

gaggattcag caaatgaaga ttcagtggat gctaagccag accggtcctc gtttgtaccg     2400

tccctcttca gtaagaagaa gaaaaatgtc accatgcgat ccatcaagac cacccgggac     2460

cgagtgccta catatcagta caacatgaat tttgaaaagc tgggcaaatg catcataata     2520

aacaacaaga actttgataa agtgacaggt atgggcgttc gaaacggaac agacaaagat     2580

gccgaggcgc tcttcaagtg cttccgaagc ctgggttttg acgtgattgt ctataatgac     2640

tgctcttgtg ccaagatgca agatctgctt aaaaaagctt ctgaagagga ccatacaaat     2700

gccgcctgct tcgcctgcat cctcttaagc catggagaag aaaatgtaat ttatgggaaa     2760

gatggtgtca caccaataaa ggatttgaca gcccacttta ggggggatag atgcaaaacc     2820

cttttagaga aacccaaact cttcttcatt caggcttgcc gagggaccga gcttgatgat     2880

ggcatccagg ccgactcggg gcccatcaat gacacagatg ctaatcctcg atacaagatc     2940

ccagtggaag ctgacttcct cttcgcctat tccacggttc caggctatta ctcgtggagg     3000

agcccaggaa gaggctcctg gtttgtgcaa gccctctgct ccatcctgga ggagcacgga     3060

aaagacctgg aaatcatgca gatcctcacc agggtgaatg acagagttgc caggcacttt     3120

gagtctcagt ctgatgaccc acacttccat gagaagaagc agatcccctg tgtggtctcc     3180

atgctcacca aggaactcta cttcagtcaa tag                                  3213


<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Synthetic oligonucleotide

<400> 38
tttttttttt tttttttttt tttt                                           24


<210> 39
<211> 268
<212> PRT
<213> Homo sapiens


<400> 39
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      
Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          
Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              
Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  
Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  
Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      
Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         
Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             
Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 
Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 
Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     
Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         
Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             
Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 
Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 
Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     
Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             

<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> antibody HCDR1

<400> 40
Ser Tyr Ala Ile Ser 
1               5   

<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody HCDR2

<400> 41
Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 42
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody HDR3

<400> 42
Pro Gly Leu Ala Ala Ala Tyr Asp Thr Gly Ser Leu Asp Tyr 
1               5                   10                  

<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody LCDR1

<400> 43
Arg Ala Ser Gln Ser Val Arg Ser Tyr Leu Ala 
1               5                   10      

<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody LCDR2

<400> 44
Asp Ala Ser Asn Arg Ala Thr 
1               5           

<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody LCDR3

<400> 45
Gln Gln Arg Asn Tyr Trp Pro Leu Thr 
1               5                   

<210> 46
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody VH

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Gly Leu Ala Ala Ala Tyr Asp Thr Gly Ser Leu Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 47
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody VL

<400> 47
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Tyr Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 48
<211> 450
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody HC

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Gly Leu Ala Ala Ala Tyr Asp Thr Gly Ser Leu Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             
Gly Lys 
    450 

<210> 49
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody LC

<400> 49
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Asn Tyr Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

