                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  NUCLEIC ACID VACCINE AGAINST THE SARS-CoV-2 CORONAVIRUS

<130>  BCT210051 QT

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  3822
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens


<220>
<221>  CDS
<222>  (1)..(3822)

<400>  1
atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag tgt gtg         48
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val           
1               5                   10                  15                

aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac agc ttt         96
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe           
            20                  25                  30                    

acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc gtg ctg        144
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu           
        35                  40                  45                        

cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg acc tgg        192
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp           
    50                  55                  60                            

ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga ttc gac        240
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp           
65                  70                  75                  80            

aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc acc gag        288
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu           
                85                  90                  95                

aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg gac agc        336
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser           
            100                 105                 110                   

aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg gtc atc        384
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile           
        115                 120                 125                       

aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc gtc tac        432
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr           
    130                 135                 140                           

tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg gtg tac        480
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr           
145                 150                 155                 160           

agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct ttc ctg        528
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu           
                165                 170                 175               

atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc gag ttc        576
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe           
            180                 185                 190                   

gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag cac acc        624
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr           
        195                 200                 205                       

cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct ctg gaa        672
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu           
    210                 215                 220                           

ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt cag aca        720
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr           
225                 230                 235                 240           

ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc        768
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser           
                245                 250                 255               

gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct        816
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro           
            260                 265                 270                   

aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc        864
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala           
        275                 280                 285                       

gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag        912
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys           
    290                 295                 300                           

tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg        960
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val           
305                 310                 315                 320           

cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc       1008
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys           
                325                 330                 335               

ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc       1056
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala           
            340                 345                 350                   

tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg       1104
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu           
        355                 360                 365                       

tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct       1152
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro           
    370                 375                 380                           

acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc       1200
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe           
385                 390                 395                 400           

gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc       1248
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly           
                405                 410                 415               

aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt       1296
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys           
            420                 425                 430                   

gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac       1344
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn           
        435                 440                 445                       

tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc       1392
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe           
    450                 455                 460                           

gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt       1440
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys           
465                 470                 475                 480           

aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc       1488
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly           
                485                 490                 495               

ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg       1536
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val           
            500                 505                 510                   

ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag       1584
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys           
        515                 520                 525                       

aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac       1632
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn           
    530                 535                 540                           

ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg       1680
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu           
545                 550                 555                 560           

cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac gcc gtt       1728
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val           
                565                 570                 575               

aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc       1776
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe           
            580                 585                 590                   

ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg       1824
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val           
        595                 600                 605                       

gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg gcc att       1872
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile           
    610                 615                 620                           

cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc       1920
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser           
625                 630                 635                 640           

aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg       1968
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val           
                645                 650                 655               

aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc       2016
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala           
            660                 665                 670                   

agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct gtg gcc       2064
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala           
        675                 680                 685                       

agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag aac agc       2112
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser           
    690                 695                 700                           

gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc acc atc       2160
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile           
705                 710                 715                 720           

agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg       2208
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val           
                725                 730                 735               

gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg       2256
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu           
            740                 745                 750                   

ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca       2304
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr           
        755                 760                 765                       

ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa       2352
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln           
    770                 775                 780                           

gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc       2400
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe           
785                 790                 795                 800           

aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc       2448
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser           
                805                 810                 815               

ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc       2496
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly           
            820                 825                 830                   

ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat       2544
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp           
        835                 840                 845                       

ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg       2592
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu           
    850                 855                 860                           

ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc       2640
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly           
865                 870                 875                 880           

aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc       2688
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile           
                885                 890                 895               

ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc       2736
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr           
            900                 905                 910                   

cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac       2784
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn           
        915                 920                 925                       

agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc       2832
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala           
    930                 935                 940                           

ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac       2880
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn           
945                 950                 955                 960           

acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg       2928
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val           
                965                 970                 975               

ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag gtg cag       2976
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln           
            980                 985                 990                   

atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc tac gtt     3024
Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val         
        995                 1000                 1005                     

acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct gcc aat        3069
Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn            
    1010                 1015                 1020                        

ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag agc aag        3114
Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys            
    1025                 1030                 1035                        

aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc ttc cct        3159
Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro            
    1040                 1045                 1050                        

cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca tac gtg        3204
Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val            
    1055                 1060                 1065                        

ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc tgc cac        3249
Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His            
    1070                 1075                 1080                        

gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg tcc aac        3294
Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn            
    1085                 1090                 1095                        

ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag ccc cag        3339
Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln            
    1100                 1105                 1110                        

atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc gac gtc        3384
Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val            
    1115                 1120                 1125                        

gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg cag ccc        3429
Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro            
    1130                 1135                 1140                        

gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt aag aac        3474
Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn            
    1145                 1150                 1155                        

cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga atc aat        3519
His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn            
    1160                 1165                 1170                        

gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg aac gag        3564
Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu            
    1175                 1180                 1185                        

gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa gaa ctg        3609
Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu            
    1190                 1195                 1200                        

ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc tgg ctg        3654
Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu            
    1205                 1210                 1215                        

ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca atc atg        3699
Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met            
    1220                 1225                 1230                        

ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc tgt tgt        3744
Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys            
    1235                 1240                 1245                        

agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct gag ccc        3789
Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro            
    1250                 1255                 1260                        

gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                         3822
Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                                 
    1265                 1270                                             


<210>  2
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  585
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for  RBD


<220>
<221>  CDS
<222>  (1)..(585)

<400>  3
aat atc acc aat ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga         48
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg           
1               5                   10                  15                

ttc gcc tct gtg tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg         96
Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val           
            20                  25                  30                    

gcc gac tac tcc gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag        144
Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys           
        35                  40                  45                        

tgc tac ggc gtg tcc cct acc aag ctg aac gac ctg tgc ttc aca aac        192
Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn           
    50                  55                  60                            

gtg tac gcc gac agc ttc gtg atc cgg gga gat gaa gtg cgg cag att        240
Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile           
65                  70                  75                  80            

gcc cct gga cag aca ggc aag atc gcc gac tac aac tac aag ctg ccc        288
Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro           
                85                  90                  95                

gac gac ttc acc ggc tgt gtg att gcc tgg aac agc aac aac ctg gac        336
Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp           
            100                 105                 110                   

tcc aaa gtc ggc ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag        384
Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys           
        115                 120                 125                       

tcc aat ctg aag ccc ttc gag cgg gac atc tcc acc gag atc tat cag        432
Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln           
    130                 135                 140                           

gcc ggc agc acc cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc        480
Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe           
145                 150                 155                 160           

cca ctg cag tcc tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag        528
Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln           
                165                 170                 175               

ccc tac aga gtg gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc        576
Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala           
            180                 185                 190                   

aca gtg tga                                                            585
Thr Val                                                                   
                                                                          


<210>  4
<211>  194
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
        35                  40                  45              


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
    50                  55                  60                  


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
65                  70                  75                  80  


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
                85                  90                  95      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
            100                 105                 110         


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
        115                 120                 125             


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
    130                 135                 140                 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
145                 150                 155                 160 


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
                165                 170                 175     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
            180                 185                 190         


Thr Val 
        


<210>  5
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (2019-nCoV signal peptide)

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu 
        


<210>  6
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (CD5 signal peptide)

<400>  6

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu 
            20                  25      


<210>  7
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (IL2 signal peptide)

<400>  7

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn 
            


<210>  8
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (PADRE epitope)

<400>  8

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  9
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (linker)

<400>  9

Ser Gly Ser Gly 
1               


<210>  10
<211>  3828
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz


<220>
<221>  CDS
<222>  (7)..(3828)

<400>  10
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

cac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                 3828
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                         
            1265                 1270                                     


<210>  11
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  12
<211>  3882
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_with_nonnatural pan 
       DR epitope (PADRE)


<220>
<221>  CDS
<222>  (7)..(3882)

<400>  12
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

cac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tct gga  agc        3834
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Ser Gly  Ser            
            1265                 1270                 1275                

ggc gcc aag ttt  gtg gct gcc tgg aca  ctg aaa gcc gcc gct  tga        3879
Gly Ala Lys Phe  Val Ala Ala Trp Thr  Leu Lys Ala Ala Ala                 
            1280                 1285                 1290                

tga                                                                   3882


<210>  13
<211>  1290
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Ser Gly  Ser Gly Ala 
    1265                 1270                 1275             


Lys Phe  Val Ala Ala Trp Thr  Leu Lys Ala Ala Ala  
    1280                 1285                 1290 


<210>  14
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for Antigen_2a_nCovRDB_SPnCov_OPT_koz


<220>
<221>  CDS
<222>  (7)..(651)

<400>  14
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac ctg        432
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu           
            130                 135                 140                   

tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg gaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu           
    160                 165                 170                           

ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

aat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tga                                    651
Leu Leu His Ala Pro Ala Thr Val                                           
            210                                                           


<210>  15
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val 
    210                 


<210>  16
<211>  705
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_2a_nCovRDB_SPnCov_OPT_koz_withPADRE


<220>
<221>  CDS
<222>  (7)..(705)

<400>  16
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac ctg        432
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu           
            130                 135                 140                   

tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg gaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu           
    160                 165                 170                           

ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

aat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tct gga agc ggc gcc aag ttt gtg        672
Leu Leu His Ala Pro Ala Thr Val Ser Gly Ser Gly Ala Lys Phe Val           
            210                 215                 220                   

gct gcc tgg aca ctg aaa gcc gcc gct tga tga                            705
Ala Ala Trp Thr Leu Lys Ala Ala Ala                                       
        225                 230                                           


<210>  17
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
                165                 170                 175     


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val Ser Gly Ser Gly Ala Lys Phe Val Ala Ala 
    210                 215                 220                 


Trp Thr Leu Lys Ala Ala Ala 
225                 230     


<210>  18
<211>  675
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for Antigen_2b_nCovRDB_SP-CD5_OPT_koz


<220>
<221>  CDS
<222>  (7)..(675)

<400>  18
gccacc atg ccc atg ggg tct ctg caa ccg ctg gcc acc ttg tac ctg          48
       Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu            
       1               5                   10                             

ctg ggg atg ctg gtc gct tcc tgc ctc gga cgg ctg gtc gct aat atc         96
Leu Gly Met Leu Val Ala Ser Cys Leu Gly Arg Leu Val Ala Asn Ile           
15                  20                  25                  30            

acc aat ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc        144
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala           
                35                  40                  45                

tct gtg tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac        192
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp           
            50                  55                  60                    

tac tcc gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac        240
Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr           
        65                  70                  75                        

ggc gtg tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac        288
Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr           
    80                  85                  90                            

gcc gac agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct        336
Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro           
95                  100                 105                 110           

gga cag aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac        384
Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp           
                115                 120                 125               

ttc acc ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa        432
Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys           
            130                 135                 140                   

gtc ggc ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat        480
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn           
        145                 150                 155                       

ctg aag ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc        528
Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly           
    160                 165                 170                           

agc acc cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg        576
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu           
175                 180                 185                 190           

cag tcc tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac        624
Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr           
                195                 200                 205               

aga gtg gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg        672
Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val           
            210                 215                 220                   

tga                                                                    675


<210>  19
<211>  222
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Val Ala Asn Ile Thr Asn 
            20                  25                  30          


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
        35                  40                  45              


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
    50                  55                  60                  


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
65                  70                  75                  80  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
                85                  90                  95      


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
            100                 105                 110         


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
        115                 120                 125             


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
    130                 135                 140                 


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
145                 150                 155                 160 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
                165                 170                 175     


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
            180                 185                 190         


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
        195                 200                 205             


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
    210                 215                 220         


<210>  20
<211>  729
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_2b_nCovRDB_SP-CD5_OPT_koz_withPADRE


<220>
<221>  CDS
<222>  (7)..(729)

<400>  20
gccacc atg ccc atg ggg tct ctg caa ccg ctg gcc acc ttg tac ctg          48
       Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu            
       1               5                   10                             

ctg ggg atg ctg gtc gct tcc tgc ctc gga cgg ctg gtc gct aat atc         96
Leu Gly Met Leu Val Ala Ser Cys Leu Gly Arg Leu Val Ala Asn Ile           
15                  20                  25                  30            

acc aat ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc        144
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala           
                35                  40                  45                

tct gtg tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac        192
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp           
            50                  55                  60                    

tac tcc gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac        240
Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr           
        65                  70                  75                        

ggc gtg tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac        288
Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr           
    80                  85                  90                            

gcc gac agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct        336
Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro           
95                  100                 105                 110           

gga cag aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac        384
Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp           
                115                 120                 125               

ttc acc ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa        432
Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys           
            130                 135                 140                   

gtc ggc ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat        480
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn           
        145                 150                 155                       

ctg aag ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc        528
Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly           
    160                 165                 170                           

agc acc cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg        576
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu           
175                 180                 185                 190           

cag tcc tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac        624
Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr           
                195                 200                 205               

aga gtg gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg        672
Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val           
            210                 215                 220                   

tct gga agc ggc gcc aag ttt gtg gct gcc tgg aca ctg aaa gcc gcc        720
Ser Gly Ser Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala           
        225                 230                 235                       

gct tga tga                                                            729
Ala                                                                       
                                                                          


<210>  21
<211>  239
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Val Ala Asn Ile Thr Asn 
            20                  25                  30          


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
        35                  40                  45              


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
    50                  55                  60                  


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
65                  70                  75                  80  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
                85                  90                  95      


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
            100                 105                 110         


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
        115                 120                 125             


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
    130                 135                 140                 


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
145                 150                 155                 160 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
                165                 170                 175     


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
            180                 185                 190         


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
        195                 200                 205             


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Ser Gly 
    210                 215                 220                 


Ser Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
225                 230                 235                 


<210>  22
<211>  654
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for Antigen_2c_nCovRDB_SP-IL2_OPT_koz


<220>
<221>  CDS
<222>  (7)..(654)

<400>  22
gccacc atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt          48
       Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu            
       1               5                   10                             

gca ctt gtc aca aac agt gca aat atc acc aat ctg tgc ccc ttc ggc         96
Ala Leu Val Thr Asn Ser Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly           
15                  20                  25                  30            

gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg        144
Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg           
                35                  40                  45                

aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc        192
Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser           
            50                  55                  60                    

gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg        240
Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu           
        65                  70                  75                        

aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg atc cgg        288
Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg           
    80                  85                  90                            

gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag atc gcc        336
Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala           
95                  100                 105                 110           

gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc        384
Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala           
                115                 120                 125               

tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac        432
Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr           
            130                 135                 140                   

ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac        480
Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp           
        145                 150                 155                       

atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg        528
Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val           
    160                 165                 170                           

gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc        576
Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro           
175                 180                 185                 190           

aca aat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc        624
Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe           
                195                 200                 205               

gaa ctg ctg cat gcc cct gcc aca gtg tga                                654
Glu Leu Leu His Ala Pro Ala Thr Val                                       
            210                 215                                       


<210>  23
<211>  215
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
            20                  25                  30          


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
        35                  40                  45              


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
    50                  55                  60                  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
65                  70                  75                  80  


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
                85                  90                  95      


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
            100                 105                 110         


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
        115                 120                 125             


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
    130                 135                 140                 


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
145                 150                 155                 160 


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
                165                 170                 175     


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
            180                 185                 190         


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
        195                 200                 205             


Leu His Ala Pro Ala Thr Val 
    210                 215 


<210>  24
<211>  708
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide  for 
       Antigen_2c_nCovRDB_SP-IL2_OPT_kozwithPADRE


<220>
<221>  CDS
<222>  (7)..(708)

<400>  24
gccacc atg tac agg atg caa ctc ctg tct tgc att gca cta agt ctt          48
       Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu            
       1               5                   10                             

gca ctt gtc aca aac agt gca aat atc acc aat ctg tgc ccc ttc ggc         96
Ala Leu Val Thr Asn Ser Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly           
15                  20                  25                  30            

gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg        144
Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg           
                35                  40                  45                

aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc        192
Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser           
            50                  55                  60                    

gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg        240
Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu           
        65                  70                  75                        

aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg atc cgg        288
Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg           
    80                  85                  90                            

gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag atc gcc        336
Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala           
95                  100                 105                 110           

gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc        384
Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala           
                115                 120                 125               

tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac        432
Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr           
            130                 135                 140                   

ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac        480
Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp           
        145                 150                 155                       

atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg        528
Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val           
    160                 165                 170                           

gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc        576
Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro           
175                 180                 185                 190           

aca aat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc        624
Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe           
                195                 200                 205               

gaa ctg ctg cat gcc cct gcc aca gtg tct gga agc ggc gcc aag ttt        672
Glu Leu Leu His Ala Pro Ala Thr Val Ser Gly Ser Gly Ala Lys Phe           
            210                 215                 220                   

gtg gct gcc tgg aca ctg aaa gcc gcc gct tga tga                        708
Val Ala Ala Trp Thr Leu Lys Ala Ala Ala                                   
        225                 230                                           


<210>  25
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
            20                  25                  30          


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
        35                  40                  45              


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
    50                  55                  60                  


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
65                  70                  75                  80  


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
                85                  90                  95      


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
            100                 105                 110         


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
        115                 120                 125             


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
    130                 135                 140                 


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
145                 150                 155                 160 


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
                165                 170                 175     


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
            180                 185                 190         


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
        195                 200                 205             


Leu His Ala Pro Ala Thr Val Ser Gly Ser Gly Ala Lys Phe Val Ala 
    210                 215                 220                 


Ala Trp Thr Leu Lys Ala Ala Ala 
225                 230         


<210>  26
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  ynthetic polynucleotide for padre_seq_OPT_nt


<220>
<221>  CDS
<222>  (1)..(51)

<400>  26
tct gga agc ggc gcc aag ttt gtg gct gcc tgg aca ctg aaa gcc gcc         48
Ser Gly Ser Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala           
1               5                   10                  15                

gct                                                                     51
Ala                                                                       
                                                                          


<210>  27
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  27

Ser Gly Ser Gly Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala 
1               5                   10                  15      


Ala 
    


<210>  28
<211>  1196
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (6acd.1.A)

<400>  28

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         


Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 


Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         


Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             


Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 


Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 


Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         


Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             


Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 


Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     


Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             


Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 


Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     


Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         


Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             


Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     


Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         


Gln Leu Ile Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
        995                 1000                 1005             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1010                 1015                 1020             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1025                 1030                 1035             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1040                 1045                 1050             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1055                 1060                 1065             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1070                 1075                 1080             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1085                 1090                 1095             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1100                 1105                 1110             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1115                 1120                 1125             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1130                 1135                 1140             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1145                 1150                 1155             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1160                 1165                 1170             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1175                 1180                 1185             


Glu Gln  Tyr Ile Lys Trp Pro  Trp 
    1190                 1195     


<210>  29
<211>  3828
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding 
       antigen_XXX_nCov_Spike_full_opt_h.sapiens_koz_deltaFurin


<220>
<221>  CDS
<222>  (7)..(3828)

<400>  29
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

cac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc gga agc gcc agc tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                 3828
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                         
            1265                 1270                                     


<210>  30
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  31
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding 
       antigen_2a_nCovRDB_SPnCov_OPT_koz_Var1


<220>
<221>  CDS
<222>  (7)..(651)

<400>  31
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gta tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac ctg        432
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu           
            130                 135                 140                   

tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg aaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys           
    160                 165                 170                           

ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tga                                    651
Leu Leu His Ala Pro Ala Thr Val                                           
            210                                                           


<210>  32
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val 
    210                 


<210>  33
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding 
       antigen_2a_nCovRDB_SPnCov_OPT_koz_Var2


<220>
<221>  CDS
<222>  (7)..(651)

<400>  33
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac ctg        432
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu           
            130                 135                 140                   

tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac ggc gtg aaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys           
    160                 165                 170                           

ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tga                                    651
Leu Leu His Ala Pro Ala Thr Val                                           
            210                                                           


<210>  34
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val 
    210                 


<210>  35
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide encoding 
       antigen_2a_nCovRDB_SPnCov_OPT_koz_Var3


<220>
<221>  CDS
<222>  (7)..(651)

<400>  35
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gta tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aag aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac ctg        432
Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu           
            130                 135                 140                   

ttc cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Phe Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc aac acc cct tgt aac ggc gtg aaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Asn Thr Pro Cys Asn Gly Val Lys           
    160                 165                 170                           

ggc ttc aac tgc tac tcc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tga                                    651
Leu Leu His Ala Pro Ala Thr Val                                           
            210                                                           


<210>  36
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Phe Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Asn Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     


Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val 
    210                 


<210>  37
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide coding for 
       Antigen_2a_nCovRDB_SPnCov_OPT_koz_Var4


<220>
<221>  CDS
<222>  (7)..(651)

<400>  37
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg gtc gct aat atc acc aat ctg tgc ccc ttc ggc gag         96
Cys Val Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu           
15                  20                  25                  30            

gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg aac cgg aag        144
Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys           
                35                  40                  45                

cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac aac tcc gcc        192
Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala           
            50                  55                  60                    

agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc aag ctg aac        240
Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn           
        65                  70                  75                        

gac ctg tgc ttc aca aac gta tac gcc gac agc ttc gtg atc cgg gga        288
Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly           
    80                  85                  90                            

gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat atc gcc gac        336
Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp           
95                  100                 105                 110           

tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg att gcc tgg        384
Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp           
                115                 120                 125               

aac agc aag aac ctg gac tcc aaa gtc ggc ggc aac tac aat tac cgg        432
Asn Ser Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg           
            130                 135                 140                   

tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag cgg gac atc        480
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile           
        145                 150                 155                       

tcc acc gag atc tat cag gcc ggc aac acc cct tgt aac ggc gtg aaa        528
Ser Thr Glu Ile Tyr Gln Ala Gly Asn Thr Pro Cys Asn Gly Val Lys           
    160                 165                 170                           

ggc ttc aac tgc tac tcc cca ctg cag tcc tac ggc ttt cag ccc aca        576
Gly Phe Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr           
175                 180                 185                 190           

tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg agc ttc gaa        624
Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu           
                195                 200                 205               

ctg ctg cat gcc cct gcc aca gtg tga                                    651
Leu Leu His Ala Pro Ala Thr Val                                           
            210                                                           


<210>  38
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Val Ala Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            20                  25                  30          


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
        35                  40                  45              


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
    50                  55                  60                  


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
65                  70                  75                  80  


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
                85                  90                  95      


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
            100                 105                 110         


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
        115                 120                 125             


Lys Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg 
    130                 135                 140                 


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
145                 150                 155                 160 


Glu Ile Tyr Gln Ala Gly Asn Thr Pro Cys Asn Gly Val Lys Gly Phe 
                165                 170                 175     


Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr Gly 
            180                 185                 190         


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
        195                 200                 205             


His Ala Pro Ala Thr Val 
    210                 


<210>  39
<211>  3771
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3771)

<400>  39
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

cac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc tga                                  3771
Cys Cys Ser Cys  Gly Ser Cys Cys                                          
            1250                                                          


<210>  40
<211>  1254
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys 
    1250                 


<210>  41
<211>  3828
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_2P


<220>
<221>  CDS
<222>  (7)..(3828)

<400>  41
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc aag atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca aat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag gac gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

cac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac ccg ccg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc acc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  gtc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                 3828
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                         
            1265                 1270                                     


<210>  42
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  42

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  43
<211>  3819
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_UK


<220>
<221>  CDS
<222>  (7)..(3819)

<400>  43
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc tcc ggc acc aat ggc acc aag aga ttc gac        240
Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp           
        65                  70                  75                        

aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc acc gag        288
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu           
    80                  85                  90                            

aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg gac agc        336
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser           
95                  100                 105                 110           

aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg gtc atc        384
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile           
                115                 120                 125               

aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc gtc tac        432
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr           
            130                 135                 140                   

cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg gtg tac agc        480
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser           
        145                 150                 155                       

agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct ttc ctg atg        528
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met           
    160                 165                 170                           

gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc gag ttc gtg        576
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val           
175                 180                 185                 190           

ttc aag aac atc gac ggc tac ttc aag atc tac agc aag cac acc cct        624
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro           
                195                 200                 205               

atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct ctg gaa ccc        672
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro           
            210                 215                 220                   

ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt cag aca ctg        720
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu           
        225                 230                 235                       

ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gac gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc cac aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gcc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc atc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg gcc aga ctg gac aag gtg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc cac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc aag ttc gac gag  gac gat tct gag ccc  gtg        3789
Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val            
            1250                 1255                 1260                

ctg aag ggc gtg  aaa ctg cac tac acc  tga                             3819
Leu Lys Gly Val  Lys Leu His Tyr Thr                                      
            1265                 1270                                     


<210>  44
<211>  1270
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  45
<211>  3762
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_UK_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3762)

<400>  45
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc tcc ggc acc aat ggc acc aag aga ttc gac        240
Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp           
        65                  70                  75                        

aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc acc gag        288
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu           
    80                  85                  90                            

aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg gac agc        336
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser           
95                  100                 105                 110           

aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg gtc atc        384
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile           
                115                 120                 125               

aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc gtc tac        432
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr           
            130                 135                 140                   

cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg gtg tac agc        480
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser           
        145                 150                 155                       

agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct ttc ctg atg        528
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met           
    160                 165                 170                           

gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc gag ttc gtg        576
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val           
175                 180                 185                 190           

ttc aag aac atc gac ggc tac ttc aag atc tac agc aag cac acc cct        624
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro           
                195                 200                 205               

atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct ctg gaa ccc        672
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro           
            210                 215                 220                   

ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt cag aca ctg        720
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu           
        225                 230                 235                       

ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gac gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc cac aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gcc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc atc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg gcc aga ctg gac aag gtg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc cac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc tga                                              3762
Cys Gly Ser Cys  Cys                                                      
            1250                                                          


<210>  46
<211>  1251
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys 
    1250     


<210>  47
<211>  3819
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_UK_2P


<220>
<221>  CDS
<222>  (7)..(3819)

<400>  47
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc tcc ggc acc aat ggc acc aag aga ttc gac        240
Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp           
        65                  70                  75                        

aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc acc gag        288
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu           
    80                  85                  90                            

aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg gac agc        336
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser           
95                  100                 105                 110           

aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg gtc atc        384
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile           
                115                 120                 125               

aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc gtc tac        432
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr           
            130                 135                 140                   

cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg gtg tac agc        480
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser           
        145                 150                 155                       

agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct ttc ctg atg        528
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met           
    160                 165                 170                           

gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc gag ttc gtg        576
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val           
175                 180                 185                 190           

ttc aag aac atc gac ggc tac ttc aag atc tac agc aag cac acc cct        624
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro           
                195                 200                 205               

atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct ctg gaa ccc        672
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro           
            210                 215                 220                   

ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt cag aca ctg        720
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu           
        225                 230                 235                       

ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gac gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc cac aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gcc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc atc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg gcc aga ctg gac ccg ccg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc cac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc aag ttc gac gag  gac gat tct gag ccc  gtg        3789
Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val            
            1250                 1255                 1260                

ctg aag ggc gtg  aaa ctg cac tac acc  tga                             3819
Leu Lys Gly Val  Lys Leu His Tyr Thr                                      
            1265                 1270                                     


<210>  48
<211>  1270
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  49
<211>  3762
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_UK_2P_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3762)

<400>  49
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ctg acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc tcc ggc acc aat ggc acc aag aga ttc gac        240
Thr Trp Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp           
        65                  70                  75                        

aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc acc gag        288
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu           
    80                  85                  90                            

aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg gac agc        336
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser           
95                  100                 105                 110           

aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg gtc atc        384
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile           
                115                 120                 125               

aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc gtc tac        432
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr           
            130                 135                 140                   

cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg gtg tac agc        480
His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser           
        145                 150                 155                       

agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct ttc ctg atg        528
Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met           
    160                 165                 170                           

gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc gag ttc gtg        576
Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val           
175                 180                 185                 190           

ttc aag aac atc gac ggc tac ttc aag atc tac agc aag cac acc cct        624
Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro           
                195                 200                 205               

atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct ctg gaa ccc        672
Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro           
            210                 215                 220                   

ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt cag aca ctg        720
Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu           
        225                 230                 235                       

ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aag       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg gaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gac gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc cac aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gcc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc atc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg gcc aga ctg gac ccg ccg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc cac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc tga                                              3762
Cys Gly Ser Cys  Cys                                                      
            1250                                                          


<210>  50
<211>  1251
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys 
    1250     


<210>  51
<211>  3819
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthtic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_SA


<220>
<221>  CDS
<222>  (7)..(3819)

<400>  51
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gcc aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg ggt ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag acc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc ccc aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gtc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc gac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc aag ttc gac gag  gac gat tct gag ccc  gtg        3789
Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val            
            1250                 1255                 1260                

ctg aag ggc gtg  aaa ctg cac tac acc  tga                             3819
Leu Lys Gly Val  Lys Leu His Tyr Thr                                      
            1265                 1270                                     


<210>  52
<211>  1270
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  53
<211>  3762
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_SA_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3762)

<400>  53
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gcc aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg ggt ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag acc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc ccc aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gtc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc gac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc tga                                              3762
Cys Gly Ser Cys  Cys                                                      
            1250                                                          


<210>  54
<211>  1251
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys 
    1250     


<210>  55
<211>  3819
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_SA_2P


<220>
<221>  CDS
<222>  (7)..(3819)

<400>  55
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gcc aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg ggt ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag acc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc ccc aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gtc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg agc aga ctg gac ccg ccg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc gac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc aag ttc gac gag  gac gat tct gag ccc  gtg        3789
Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val            
            1250                 1255                 1260                

ctg aag ggc gtg  aaa ctg cac tac acc  tga                             3819
Leu Lys Gly Val  Lys Leu His Tyr Thr                                      
            1265                 1270                                     


<210>  56
<211>  1270
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  57
<211>  3762
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_SA_2P_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3762)

<400>  57
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc acc aga aca cag ctg cct cca gcc tac acc aac         96
Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gcc aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac gac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg cgc        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg ggt ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag acc ctg cac aga agc tac ctg aca cct ggc gat agc agc agc gga        768
Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly           
    240                 245                 250                           

tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg cag cct aga        816
Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg           
255                 260                 265                 270           

acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc gac gcc gtg        864
Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val           
                275                 280                 285               

gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc ctg aag tcc        912
Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser           
            290                 295                 300                   

ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc cgg gtg cag        960
Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln           
        305                 310                 315                       

ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat ctg tgc ccc       1008
Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro           
    320                 325                 330                           

ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg tac gcc tgg       1056
Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp           
335                 340                 345                 350           

aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc gtg ctg tac       1104
Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr           
                355                 360                 365               

aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg tcc cct acc       1152
Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr           
            370                 375                 380                   

aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac agc ttc gtg       1200
Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val           
        385                 390                 395                       

atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag aca ggc aat       1248
Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn           
    400                 405                 410                           

atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc ggc tgt gtg       1296
Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val           
415                 420                 425                 430           

att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc ggc aac tac       1344
Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr           
                435                 440                 445               

aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag ccc ttc gag       1392
Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu           
            450                 455                 460                   

cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc cct tgt aac       1440
Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn           
        465                 470                 475                       

ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc tac ggc ttt       1488
Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe           
    480                 485                 490                           

cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg gtg gtg ctg       1536
Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu           
495                 500                 505                 510           

agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc cct aag aaa       1584
Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys           
                515                 520                 525               

agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac ttc aac ggc       1632
Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly           
            530                 535                 540                   

ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag ttc ctg cca       1680
Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro           
        545                 550                 555                       

ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac gcc gtt aga       1728
Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg           
    560                 565                 570                           

gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc agc ttc ggc       1776
Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly           
575                 580                 585                 590           

gga gtg tct gtg atc acc cct ggc acc aac acc agc aat cag gtg gca       1824
Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala           
                595                 600                 605               

gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg gcc att cac       1872
Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His           
            610                 615                 620                   

gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc ggc agc aat       1920
Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn           
        625                 630                 635                       

gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag cac gtg aac       1968
Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn           
    640                 645                 650                           

aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc tgt gcc agc       2016
Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser           
655                 660                 665                 670           

tac cag aca cag aca aac agc ccc aga cgg gcc aga tct gtg gcc agc       2064
Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser           
                675                 680                 685               

cag agc atc att gcc tac aca atg tct ctg ggc gtc gag aac agc gtg       2112
Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val           
            690                 695                 700                   

gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc acc atc agc       2160
Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser           
        705                 710                 715                       

gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc agc gtg gac       2208
Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp           
    720                 725                 730                           

tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc aac ctg ctg       2256
Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu           
735                 740                 745                 750           

ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc ctg aca ggg       2304
Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly           
                755                 760                 765               

atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc gcc caa gtg       2352
Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val           
            770                 775                 780                   

aag cag atc tac aag acc cct cct atc aag gac ttc ggc ggc ttc aat       2400
Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn           
        785                 790                 795                       

ttc agc cag att ctg ccc gat cct agc aag ccc agc aag cgg agc ttc       2448
Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe           
    800                 805                 810                           

atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac gcc ggc ttc       2496
Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe           
815                 820                 825                 830           

atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc agg gat ctg       2544
Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu           
                835                 840                 845               

att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct cct ctg ctg       2592
Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu           
            850                 855                 860                   

acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg gcc ggc aca       2640
Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr           
        865                 870                 875                       

atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg cag atc ccc       2688
Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro           
    880                 885                 890                           

ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga gtg acc cag       2736
Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln           
895                 900                 905                 910           

aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag ttc aac agc       2784
Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser           
                915                 920                 925               

gcc atc ggc aag atc cag gac agc ctg agc agc aca gca agc gcc ctg       2832
Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu           
            930                 935                 940                   

gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca ctg aac acc       2880
Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr           
        945                 950                 955                       

ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc tct gtg ctg       2928
Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu           
    960                 965                 970                           

aac gat atc ctg agc aga ctg gac ccg ccg gaa gcc gag gtg cag atc       2976
Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile           
975                 980                 985                 990           

gac aga ctg atc acc gga agg ctg cag tcc  ctg cag acc tac gtt  acc     3024
Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr         
                995                 1000                 1005             

cag cag ctg atc  aga gcc gcc gag att  aga gcc tct gcc aat  ctg        3069
Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu            
            1010                 1015                 1020                

gcc gcc acc aag  atg tct gag tgt gtg  ctg ggc cag agc aag  aga        3114
Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg            
            1025                 1030                 1035                

gtg gac ttt tgc  ggc aag ggc tac cac  ctg atg agc ttc cct  cag        3159
Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln            
            1040                 1045                 1050                

tct gcc cct cac  ggc gtg gtg ttt ctg  cac gtg aca tac gtg  ccc        3204
Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro            
            1055                 1060                 1065                

gct caa gag aag  aat ttc acc acc gct  cca gcc atc tgc cac  gac        3249
Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp            
            1070                 1075                 1080                

ggc aaa gcc cac  ttt cct aga gaa ggc  gtg ttc gtg tcc aac  ggc        3294
Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly            
            1085                 1090                 1095                

acc cat tgg ttc  gtg acc cag cgg aac  ttc tac gag ccc cag  atc        3339
Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile            
            1100                 1105                 1110                

atc acc acc gac  aac acc ttc gtg tct  ggc aac tgc gac gtc  gtg        3384
Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val            
            1115                 1120                 1125                

atc ggc att gtg  aac aat acc gtg tac  gac cct ctg cag ccc  gag        3429
Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu            
            1130                 1135                 1140                

ctg gac agc ttc  aaa gag gaa ctg gat  aag tac ttt aag aac  cac        3474
Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His            
            1145                 1150                 1155                

aca agc ccc gac  gtg gac ctg ggc gat  atc agc gga atc aat  gcc        3519
Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala            
            1160                 1165                 1170                

agc gtc gtg aac  atc cag aaa gag atc  gac cgg ctg aac gag  gtg        3564
Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val            
            1175                 1180                 1185                

gcc aag aat ctg  aac gag agc ctg atc  gac ctg caa gaa ctg  ggg        3609
Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly            
            1190                 1195                 1200                

aag tac gag cag  tac atc aag tgg ccc  tgg tac atc tgg ctg  ggc        3654
Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly            
            1205                 1210                 1215                

ttt atc gcc gga  ctg att gcc atc gtg  atg gtc aca atc atg  ctg        3699
Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu            
            1220                 1225                 1230                

tgt tgc atg acc  agc tgc tgt agc tgc  ctg aag ggc tgt tgt  agc        3744
Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser            
            1235                 1240                 1245                

tgt ggc agc tgc  tgc tga                                              3762
Cys Gly Ser Cys  Cys                                                      
            1250                                                          


<210>  58
<211>  1251
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys 
    1250     


<210>  59
<211>  3828
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_Br


<220>
<221>  CDS
<222>  (7)..(3828)

<400>  59
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc aac aga aca cag ctg cct tca gcc tac acc aac         96
Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac tac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg agt        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc acg atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

tac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc atc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  ttc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                 3828
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                         
            1265                 1270                                     


<210>  60
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  61
<211>  3771
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_Br_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3771)

<400>  61
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc aac aga aca cag ctg cct tca gcc tac acc aac         96
Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac tac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg agt        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc acg atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

tac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac aag gtg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc atc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  ttc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc tga                                  3771
Cys Cys Ser Cys  Gly Ser Cys Cys                                          
            1250                                                          


<210>  62
<211>  1254
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  62

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys 
    1250                 


<210>  63
<211>  3828
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_Br_2P


<220>
<221>  CDS
<222>  (7)..(3828)

<400>  63
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc aac aga aca cag ctg cct tca gcc tac acc aac         96
Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac tac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg agt        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc acg atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

tac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac ccg ccg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc atc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  ttc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc aag  ttc gac gag gac gat  tct        3789
Cys Cys Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser            
            1250                 1255                 1260                

gag ccc gtg ctg  aag ggc gtg aaa ctg  cac tac acc tga                 3828
Glu Pro Val Leu  Lys Gly Val Lys Leu  His Tyr Thr                         
            1265                 1270                                     


<210>  64
<211>  1273
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  65
<211>  3771
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide for 
       Antigen_1_nCov_Spike_full_opt_h.sapiens_koz_Br_2P_delta_Cter


<220>
<221>  CDS
<222>  (7)..(3771)

<400>  65
gccacc atg ttc gtg ttt ctg gtg ctg ctg cct ctg gtg tcc agc cag          48
       Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln            
       1               5                   10                             

tgt gtg aac ttt acc aac aga aca cag ctg cct tca gcc tac acc aac         96
Cys Val Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn           
15                  20                  25                  30            

agc ttt acc aga ggc gtg tac tac ccc gac aag gtg ttc aga tcc agc        144
Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser           
                35                  40                  45                

gtg ctg cac tct acc cag gac ctg ttc ctg cct ttc ttc agc aac gtg        192
Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val           
            50                  55                  60                    

acc tgg ttc cac gcc atc cac gtg tcc ggc acc aat ggc acc aag aga        240
Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg           
        65                  70                  75                        

ttc gac aac ccc gtg ctg ccc ttc aac gac ggg gtg tac ttt gcc agc        288
Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser           
    80                  85                  90                            

acc gag aag tcc aac atc atc aga ggc tgg atc ttc ggc acc aca ctg        336
Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu           
95                  100                 105                 110           

gac agc aag acc cag agc ctg ctg atc gtg aac aac gcc acc aac gtg        384
Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val           
                115                 120                 125               

gtc atc aaa gtg tgc gag ttc cag ttc tgc aac tac ccc ttc ctg ggc        432
Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly           
            130                 135                 140                   

gtc tac tac cac aag aac aac aag agc tgg atg gaa agc gag ttc cgg        480
Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg           
        145                 150                 155                       

gtg tac agc agc gcc aac aac tgc acc ttc gag tac gtg tcc cag cct        528
Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro           
    160                 165                 170                           

ttc ctg atg gac ctg gaa ggc aag cag ggc aac ttc aag aac ctg agt        576
Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser           
175                 180                 185                 190           

gag ttc gtg ttc aag aac atc gac ggc tac ttc aag atc tac agc aag        624
Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys           
                195                 200                 205               

cac acc cct atc aac ctc gtg cgg gat ctg cct cag ggc ttc tct gct        672
His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala           
            210                 215                 220                   

ctg gaa ccc ctg gtg gat ctg ccc atc ggc atc aac atc acc cgg ttt        720
Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe           
        225                 230                 235                       

cag aca ctg ctg gcc ctg cac aga agc tac ctg aca cct ggc gat agc        768
Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser           
    240                 245                 250                           

agc agc gga tgg aca gct ggt gcc gcc gct tac tat gtg ggc tac ctg        816
Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu           
255                 260                 265                 270           

cag cct aga acc ttc ctg ctg aag tac aac gag aac ggc acc atc acc        864
Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr           
                275                 280                 285               

gac gcc gtg gat tgt gct ctg gat cct ctg agc gag aca aag tgc acc        912
Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr           
            290                 295                 300                   

ctg aag tcc ttc acc gtg gaa aag ggc atc tac cag acc agc aac ttc        960
Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe           
        305                 310                 315                       

cgg gtg cag ccc acc gaa tcc atc gtg cgg ttc ccc aat atc acc aat       1008
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn           
    320                 325                 330                           

ctg tgc ccc ttc ggc gag gtg ttc aat gcc acc aga ttc gcc tct gtg       1056
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val           
335                 340                 345                 350           

tac gcc tgg aac cgg aag cgg atc agc aat tgc gtg gcc gac tac tcc       1104
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser           
                355                 360                 365               

gtg ctg tac aac tcc gcc agc ttc agc acc ttc aag tgc tac ggc gtg       1152
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val           
            370                 375                 380                   

tcc cct acc aag ctg aac gac ctg tgc ttc aca aac gtg tac gcc gac       1200
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp           
        385                 390                 395                       

agc ttc gtg atc cgg gga gat gaa gtg cgg cag att gcc cct gga cag       1248
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln           
    400                 405                 410                           

aca ggc acg atc gcc gac tac aac tac aag ctg ccc gac gac ttc acc       1296
Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr           
415                 420                 425                 430           

ggc tgt gtg att gcc tgg aac agc aac aac ctg gac tcc aaa gtc ggc       1344
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly           
                435                 440                 445               

ggc aac tac aat tac ctg tac cgg ctg ttc cgg aag tcc aat ctg aag       1392
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys           
            450                 455                 460                   

ccc ttc gag cgg gac atc tcc acc gag atc tat cag gcc ggc agc acc       1440
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr           
        465                 470                 475                       

cct tgt aac ggc gtg aaa ggc ttc aac tgc tac ttc cca ctg cag tcc       1488
Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser           
    480                 485                 490                           

tac ggc ttt cag ccc aca tat ggc gtg ggc tat cag ccc tac aga gtg       1536
Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val           
495                 500                 505                 510           

gtg gtg ctg agc ttc gaa ctg ctg cat gcc cct gcc aca gtg tgc ggc       1584
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly           
                515                 520                 525               

cct aag aaa agc acc aat ctc gtg aag aac aaa tgc gtg aac ttc aac       1632
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn           
            530                 535                 540                   

ttc aac ggc ctg acc ggc acc ggc gtg ctg aca gag agc aac aag aag       1680
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys           
        545                 550                 555                       

ttc ctg cca ttc cag cag ttt ggc cgg gat atc gcc gat acc aca gac       1728
Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp           
    560                 565                 570                           

gcc gtt aga gat ccc cag aca ctg gaa atc ctg gac atc acc cct tgc       1776
Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys           
575                 580                 585                 590           

agc ttc ggc gga gtg tct gtg atc acc cct ggc acc aac acc agc aat       1824
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn           
                595                 600                 605               

cag gtg gca gtg ctg tac cag ggc gtg aac tgt acc gaa gtg ccc gtg       1872
Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val           
            610                 615                 620                   

gcc att cac gcc gat cag ctg aca cct aca tgg cgg gtg tac tcc acc       1920
Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr           
        625                 630                 635                       

ggc agc aat gtg ttt cag acc aga gcc ggc tgt ctg atc gga gcc gag       1968
Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu           
    640                 645                 650                           

tac gtg aac aat agc tac gag tgc gac atc ccc atc ggc gct ggc atc       2016
Tyr Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile           
655                 660                 665                 670           

tgt gcc agc tac cag aca cag aca aac agc ccc aga cgg gcc aga tct       2064
Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser           
                675                 680                 685               

gtg gcc agc cag agc atc att gcc tac aca atg tct ctg ggc gcc gag       2112
Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu           
            690                 695                 700                   

aac agc gtg gcc tac tcc aac aac tct atc gct atc ccc acc aac ttc       2160
Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe           
        705                 710                 715                       

acc atc agc gtg acc aca gag atc ctg cct gtg tcc atg acc aag acc       2208
Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr           
    720                 725                 730                           

agc gtg gac tgc acc atg tac atc tgc ggc gat tcc acc gag tgc tcc       2256
Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser           
735                 740                 745                 750           

aac ctg ctg ctg cag tac ggc agc ttc tgc acc cag ctg aat aga gcc       2304
Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala           
                755                 760                 765               

ctg aca ggg atc gcc gtg gaa cag gac aag aac acc caa gag gtg ttc       2352
Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe           
            770                 775                 780                   

gcc caa gtg aag cag atc tac aag acc cct cct atc aag gac ttc ggc       2400
Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly           
        785                 790                 795                       

ggc ttc aat ttc agc cag att ctg ccc gat cct agc aag ccc agc aag       2448
Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys           
    800                 805                 810                           

cgg agc ttc atc gag gac ctg ctg ttc aac aaa gtg aca ctg gcc gac       2496
Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp           
815                 820                 825                 830           

gcc ggc ttc atc aag cag tat ggc gat tgt ctg ggc gac att gcc gcc       2544
Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala           
                835                 840                 845               

agg gat ctg att tgc gcc cag aag ttt aac gga ctg aca gtg ctg cct       2592
Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro           
            850                 855                 860                   

cct ctg ctg acc gat gag atg atc gcc cag tac aca tct gcc ctg ctg       2640
Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu           
        865                 870                 875                       

gcc ggc aca atc aca agc ggc tgg aca ttt gga gct ggc gcc gct ctg       2688
Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu           
    880                 885                 890                           

cag atc ccc ttt gct atg cag atg gcc tac cgg ttc aac ggc atc gga       2736
Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly           
895                 900                 905                 910           

gtg acc cag aat gtg ctg tac gag aac cag aag ctg atc gcc aac cag       2784
Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln           
                915                 920                 925               

ttc aac agc gcc atc ggc aag atc cag gac agc ctg agc agc aca gca       2832
Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala           
            930                 935                 940                   

agc gcc ctg gga aag ctg cag gac gtg gtc aac cag aat gcc cag gca       2880
Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala           
        945                 950                 955                       

ctg aac acc ctg gtc aag cag ctg tcc tcc aac ttc ggc gcc atc agc       2928
Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser           
    960                 965                 970                           

tct gtg ctg aac gat atc ctg agc aga ctg gac ccg ccg gaa gcc gag       2976
Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu           
975                 980                 985                 990           

gtg cag atc gac aga ctg atc acc gga agg  ctg cag tcc ctg cag  acc     3024
Val Gln Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr         
                995                 1000                 1005             

tac gtt acc cag  cag ctg atc aga gcc  gcc gag att aga gcc  tct        3069
Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser            
            1010                 1015                 1020                

gcc aat ctg gcc  gcc atc aag atg tct  gag tgt gtg ctg ggc  cag        3114
Ala Asn Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln            
            1025                 1030                 1035                

agc aag aga gtg  gac ttt tgc ggc aag  ggc tac cac ctg atg  agc        3159
Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser            
            1040                 1045                 1050                

ttc cct cag tct  gcc cct cac ggc gtg  gtg ttt ctg cac gtg  aca        3204
Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr            
            1055                 1060                 1065                

tac gtg ccc gct  caa gag aag aat ttc  acc acc gct cca gcc  atc        3249
Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile            
            1070                 1075                 1080                

tgc cac gac ggc  aaa gcc cac ttt cct  aga gaa ggc gtg ttc  gtg        3294
Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val            
            1085                 1090                 1095                

tcc aac ggc acc  cat tgg ttc gtg acc  cag cgg aac ttc tac  gag        3339
Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu            
            1100                 1105                 1110                

ccc cag atc atc  acc acc gac aac acc  ttc gtg tct ggc aac  tgc        3384
Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys            
            1115                 1120                 1125                

gac gtc gtg atc  ggc att gtg aac aat  acc gtg tac gac cct  ctg        3429
Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu            
            1130                 1135                 1140                

cag ccc gag ctg  gac agc ttc aaa gag  gaa ctg gat aag tac  ttt        3474
Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe            
            1145                 1150                 1155                

aag aac cac aca  agc ccc gac gtg gac  ctg ggc gat atc agc  gga        3519
Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly            
            1160                 1165                 1170                

atc aat gcc agc  ttc gtg aac atc cag  aaa gag atc gac cgg  ctg        3564
Ile Asn Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu            
            1175                 1180                 1185                

aac gag gtg gcc  aag aat ctg aac gag  agc ctg atc gac ctg  caa        3609
Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln            
            1190                 1195                 1200                

gaa ctg ggg aag  tac gag cag tac atc  aag tgg ccc tgg tac  atc        3654
Glu Leu Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile            
            1205                 1210                 1215                

tgg ctg ggc ttt  atc gcc gga ctg att  gcc atc gtg atg gtc  aca        3699
Trp Leu Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr            
            1220                 1225                 1230                

atc atg ctg tgt  tgc atg acc agc tgc  tgt agc tgc ctg aag  ggc        3744
Ile Met Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly            
            1235                 1240                 1245                

tgt tgt agc tgt  ggc agc tgc tgc tga                                  3771
Cys Cys Ser Cys  Gly Ser Cys Cys                                          
            1250                                                          


<210>  66
<211>  1254
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Phe Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys 
    1250                 


