                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  Antibodies

<130>  PF0260-WO

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  2
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  3
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  4
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Pro Pro Arg Leu Leu Leu Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Arg Gly Leu Pro Gly Ala Leu Ala Ala Gln Glu Val Gln Gln Ser 
            20                  25                  30          


Pro His Cys Thr Thr Val Pro Val Gly Ala Ser Val Asn Ile Thr Cys 
        35                  40                  45              


Ser Thr Ser Gly Gly Leu Arg Gly Ile Tyr Leu Arg Gln Leu Gly Pro 
    50                  55                  60                  


Gln Pro Gln Asp Ile Ile Tyr Tyr Glu Asp Gly Val Val Pro Thr Thr 
65                  70                  75                  80  


Asp Arg Arg Phe Arg Gly Arg Ile Asp Phe Ser Gly Ser Gln Asp Asn 
                85                  90                  95      


Leu Thr Ile Thr Met His Arg Leu Gln Leu Ser Asp Thr Gly Thr Tyr 
            100                 105                 110         


Thr Cys Gln Ala Ile Thr Glu Val Asn Val Tyr Gly Ser Gly Thr Leu 
        115                 120                 125             


Val Leu Val Thr Glu Glu Gln Ser Gln Gly Trp His Arg Cys Ser Asp 
    130                 135                 140                 


Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
145                 150                 155                 160 


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
                165                 170                 175     


Ser Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu 
            180                 185                 190         


Gly Leu Gly Val Ala Cys Val Leu Ala Arg Thr Gln Ile Lys Lys Leu 
        195                 200                 205             


Cys Ser Trp Arg Asp Lys Asn Ser Ala Ala Cys Val Val Tyr Glu Asp 
    210                 215                 220                 


Met Ser His Ser Arg Cys Asn Thr Leu Ser Ser Pro Asn Gln Tyr Gln 
225                 230                 235                 240 


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR8475

<400>  5

Gly Phe Ser Leu Ser Thr Tyr Ala Met Ser 
1               5                   10  


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR8475

<400>  6

Ala Ile Trp Ser Gly Gly Thr Thr Asp Tyr Thr Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR8475

<400>  7

Met Ala Val Ile Phe Asn Ala Tyr Thr Phe Asp Ser 
1               5                   10          


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 VR8475

<400>  8

Gln Ala Ser Gln Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR8475

<400>  9

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR8475

<400>  10

Gln Gln Gly His Ser Ser Gly Asn Val Gly Asn Asn Val 
1               5                   10              


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR7272

<400>  11

Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR7272

<400>  12

Ala Ile Gly Ser Ile Thr Ala Thr Gly Tyr Ala Arg Trp Ala Lys Gly 
1               5                   10                  15      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR7272

<400>  13

Glu Ile Tyr Val Gly Ser Ala Tyr Ala Phe Asp Ile 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 VR7272

<400>  14

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR7272

<400>  15

Leu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR7272

<400>  16

Gln Gln Gly Tyr Ile Asp Asn Val Asn Lys Gly 
1               5                   10      


<210>  17
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR8475

<400>  17

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Thr Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Trp Ser Gly Gly Thr Thr Asp Tyr Thr Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Met Ala 
                85                  90                  95      


Val Ile Phe Asn Ala Tyr Thr Phe Asp Ser Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR8475

<400>  18
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgg tggaggagtc cgggggtcgc ctggtcacgc ctgggacacc      120

cctgacactc acctgcacag tctctggatt ctccctcagt acgtatgcaa tgagctgggt      180

ccgccaggct ccagggaagg ggctggagtg gatcggagcg atttggagtg gtggtaccac      240

ggactacacg agctgggcga aaggccgatt caccatctcc aaagcctcga ccacggtgga      300

tctgaaaatc accagtccga caaccgagga cacggccacc tatttctgtg tcagaatggc      360

agtgattttt aatgcttaca cttttgattc ctggggccca ggcaccctgg tcaccgtctc      420

gagt                                                                   424


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR8475

<400>  19

Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Ser Gly Asn 
                85                  90                  95      


Val Gly Asn Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  20
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR8475

<400>  20
aagcttcgaa gccaccatga acatgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgcctatga tatgacccag actccatcct ccgtgtctgc      120

agctgtggga ggcacagtca ccatcaagtg ccaggccagt cagaacattt acagttactt      180

agcctggtat cagcagaaac cagggcagcg tcccaagctc ctgatctatg gtgcgtccac      240

tctggcatct ggggtcccat cgcggttcaa aggcagtgga tctgggacag atttcactct      300

caccatcagc gacctggagt gtgacgatgc tgccacttac tactgtcaac agggccatag      360

tagtggtaat gttggaaata atgttttcgg cggagggacc gaggtggtgg tcaaacgtac      420

g                                                                      421


<210>  21
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR7272

<400>  21

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Gly Ser Ile Thr Ala Thr Gly Tyr Ala Arg Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ser Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Ile 
                85                  90                  95      


Tyr Val Gly Ser Ala Tyr Ala Phe Asp Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR7272

<400>  22
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgc tggaggagtc cgggggtcgc ctggtcacgc ctgggacacc      120

cctgacactc acctgcacag tctctggatt ctccctcagt agctatgcaa tgggctgggt      180

ccgccaggct ccagggaagg ggctggagtg gatcggagcc attggtagta ttactgccac      240

tggctacgcg cgctgggcaa aaggccgatt cagcatctcc aagacctcga ccacggtgga      300

tctgaaaatg accagtccga caaccgagga cacggccacc tatttctgtg ccagagagat      360

ttatgttggg tctgcttatg cctttgacat ctggggccca ggcaccctgg tcaccgtctc      420

gagt                                                                   424


<210>  23
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR7272

<400>  23

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Asp Asn Val 
                85                  90                  95      


Asn Lys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 


<210>  24
<211>  415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR7272

<400>  24
aagcttcgaa gccaccatgg acacgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgtggaggt      120

agctgtggga gacactgtca ccatcaagtg tcaggccagt cagagcatta gtaactactt      180

agcctggtat cagcagaaac cagggcagcc tcccaagctc ctgatctatc tggcatctac      240

tctggcatct ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct      300

caccatcagc gacctggagt gtgccgatgc tgccacttac tattgtcaac agggttatat      360

tgataatgtt aataaaggtt tcggcggagg gaccgaggtg gtggtcaaac gtacg           415


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR7660

<400>  25

Gly Phe Ser Leu Ser Thr Tyr Asp Met Ile 
1               5                   10  


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR7660

<400>  26

Val Ile Thr Lys Thr Thr Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR7660

<400>  27

Asp Ala Asp Asp Ala Val Tyr Tyr Tyr Phe Asp Ile 
1               5                   10          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  28

Gln Ala Ser Gln Ser Ile Gly Ser Gly Leu Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR7660

<400>  29

Ala Ala Ser Thr Leu Thr Ser 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR7660

<400>  30

Gln Glu Gly Val Ser Arg Gly Asn Ile Asp Asn Ala 
1               5                   10          


<210>  31
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR7660

<400>  31

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ala Gly Phe Ser Leu Ser Thr Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Val Ile Thr Lys Thr Thr Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ala 
                85                  90                  95      


Asp Asp Ala Val Tyr Tyr Tyr Phe Asp Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR7660

<400>  32
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgg tggaggagtc cgggggtcgc ctggtcacgc ctgggacacc      120

cctgacactc acctgcacgg tcgctggatt ctccctcagt acctacgaca tgatctgggt      180

ccgccaggct ccagggaagg ggctggaata catcggagtc attactaaaa ctactaccac      240

atactacgcg aactgggcga aaggccgatt caccatctcc aaaacctcga ccacggtgga      300

tctgaaaatg accagtccga caaccgagga cacggccacc tatttctgtg ccagagatgc      360

tgatgatgct gtttattact actttgacat ctggggccca ggcaccctgg tcaccgtctc      420

gag                                                                    423


<210>  33
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR7660

<400>  33

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Ala Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Gly Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Glu Gly Val Ser Arg Gly Asn 
                85                  90                  95      


Ile Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  34
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR7660

<400>  34
aagcttcgaa gccaccatgg acatgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgcggaggt      120

agctgtggga ggcacagtca ccatcaattg ccaggccagt cagagcattg gcagtggttt      180

ggcctggtat cagcagaaac cagggcagcg tcccaaactc ctgatctatg ctgcatccac      240

tctgacatct ggggtctcat cgcggttcaa aggcagtgga tctgggacag agttcactct      300

caccatcagc ggcgtggagt gtgccgatgc tgccacttac tactgtcaag agggtgttag      360

tcgtggtaat attgataatg ccttcggcgg agggaccgag gtggtggtca aacgtacg        418


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR8850

<400>  35

Gly Phe Ser Leu Ser Ser Phe Ala Met Cys 
1               5                   10  


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR8850

<400>  36

Ile Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Thr Gly 
1               5                   10                  15      


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR8850

<400>  37

Gly Asn Gly Tyr Ala Gly Tyr Gly Tyr Asp Gly Phe Asp Pro 
1               5                   10                  


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 VR8850

<400>  38

Gln Ala Ser Gln Ser Ile Thr Ser Trp Leu Ser 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR8850

<400>  39

Ala Ala Ser Lys Leu Thr Phe 
1               5           


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR8850

<400>  40

Gln Ser Asn Tyr Gly Ser Ser Ser Ala Tyr Gly Ala 
1               5                   10          


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR8850

<400>  41

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Phe Ala 
            20                  25                  30          


Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Thr Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ser 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asn 
                85                  90                  95      


Gly Tyr Ala Gly Tyr Gly Tyr Asp Gly Phe Asp Pro Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR8850

<400>  42
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgg tggaggagtc cgggggtcgc ctggtcacgc cggggacacc      120

cctgacactc acctgcacag tctctggatt ctccctcagt agctttgcaa tgtgctgggt      180

ccgccaggct ccagggaagg gactggaata catcggaatc attaatactg gtggtagcgc      240

atactacgcg agctgggcga caggccgatt caccatctcc aaaacctcga ccacggtgga      300

tctgaaaatc tccagtccga caaccgagga cacggccacc tatttctgtg ccagaggaaa      360

tggttatgct ggttatggtt atgatggttt tgatccctgg ggcccaggca ccctggtcac      420

cgtctcgagt                                                             430


<210>  43
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR8850

<400>  43

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Thr Ser Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Lys Leu Thr Phe Gly Val Ser Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Gly Ser Ser Ser 
                85                  90                  95      


Ala Tyr Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  44
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR8850

<400>  44
aagcttcgaa gccaccatgg acacgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgctgacat tgtgatgacc cagactccag cctccgtgtc      120

tgaacctgtg ggaggcacag tcaccatcaa gtgccaggcc agtcagagca ttaccagttg      180

gttatcctgg tatcagcaga aaccagggca gcctcccaag ctcctgatct acgcggcatc      240

caaactgaca tttggggtct catcaagatt cagaggcagt ggatctggga cagagtacac      300

tctcaccatc agcgacctgg agtgtgccga tgctgccact tactactgtc aaagcaatta      360

tggtagtagt agtgcttatg gggctttcgg cggagggacc gaggtggtgg tcaaacgtac      420

g                                                                      421


