                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  Antibodies

<130>  PF0258-WO

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  283
<212>  PRT
<213>  homo sapiens

<400>  1

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  2
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR7660

<400>  3

Gly Phe Ser Leu Ser Thr Tyr Asp Met Ile 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR7660

<400>  4

Val Ile Thr Lys Thr Thr Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR7660

<400>  5

Asp Ala Asp Asp Ala Val Tyr Tyr Tyr Phe Asp Ile 
1               5                   10          


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1

<400>  6

Gln Ala Ser Gln Ser Ile Gly Ser Gly Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR7660

<400>  7

Ala Ala Ser Thr Leu Thr Ser 
1               5           


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR7660

<400>  8

Gln Glu Gly Val Ser Arg Gly Asn Ile Asp Asn Ala 
1               5                   10          


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 VR7272

<400>  9

Gly Phe Ser Leu Ser Ser Tyr Ala Met Gly 
1               5                   10  


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 VR7272

<400>  10

Ala Ile Gly Ser Ile Thr Ala Thr Gly Tyr Ala Arg Trp Ala Lys Gly 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 VR7272

<400>  11

Glu Ile Tyr Val Gly Ser Ala Tyr Ala Phe Asp Ile 
1               5                   10          


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 VR7272

<400>  12

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 VR7272

<400>  13

Leu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 VR7272

<400>  14

Gln Gln Gly Tyr Ile Asp Asn Val Asn Lys Gly 
1               5                   10      


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR7660

<400>  15

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ala Gly Phe Ser Leu Ser Thr Tyr Asp 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Val Ile Thr Lys Thr Thr Thr Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ala 
                85                  90                  95      


Asp Asp Ala Val Tyr Tyr Tyr Phe Asp Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR7660

<400>  16
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgg tggaggagtc cgggggtcgc ctggtcacgc ctgggacacc      120

cctgacactc acctgcacgg tcgctggatt ctccctcagt acctacgaca tgatctgggt      180

ccgccaggct ccagggaagg ggctggaata catcggagtc attactaaaa ctactaccac      240

atactacgcg aactgggcga aaggccgatt caccatctcc aaaacctcga ccacggtgga      300

tctgaaaatg accagtccga caaccgagga cacggccacc tatttctgtg ccagagatgc      360

tgatgatgct gtttattact actttgacat ctggggccca ggcaccctgg tcaccgtctc      420

gagt                                                                   424


<210>  17
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR7660

<400>  17

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Ala Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Gly Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Thr Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Glu Gly Val Ser Arg Gly Asn 
                85                  90                  95      


Ile Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  18
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR7660

<400>  18
aagcttcgaa gccaccatgg acatgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgcggaggt      120

agctgtggga ggcacagtca ccatcaattg ccaggccagt cagagcattg gcagtggttt      180

ggcctggtat cagcagaaac cagggcagcg tcccaaactc ctgatctatg ctgcatccac      240

tctgacatct ggggtctcat cgcggttcaa aggcagtgga tctgggacag agttcactct      300

caccatcagc ggcgtggagt gtgccgatgc tgccacttac tactgtcaag agggtgttag      360

tcgtggtaat attgataatg ccttcggcgg agggaccgag gtggtggtca aacgtacg        418


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH VR7272

<400>  19

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Gly Ser Ile Thr Ala Thr Gly Tyr Ala Arg Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ser Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Ile 
                85                  90                  95      


Tyr Val Gly Ser Ala Tyr Ala Phe Asp Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH nucl VR7272

<400>  20
aagcttcgaa gccaccatgg agactgggct gcgctggctt ctcctggtcg ctgtgctcaa       60

aggtgtccag tgtcagtcgc tggaggagtc cgggggtcgc ctggtcacgc ctgggacacc      120

cctgacactc acctgcacag tctctggatt ctccctcagt agctatgcaa tgggctgggt      180

ccgccaggct ccagggaagg ggctggagtg gatcggagcc attggtagta ttactgccac      240

tggctacgcg cgctgggcaa aaggccgatt cagcatctcc aagacctcga ccacggtgga      300

tctgaaaatg accagtccga caaccgagga cacggccacc tatttctgtg ccagagagat      360

ttatgttggg tctgcttatg cctttgacat ctggggccca ggcaccctgg tcaccgtctc      420

gagt                                                                   424


<210>  21
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL VR7272

<400>  21

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ile Asp Asn Val 
                85                  90                  95      


Asn Lys Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 


<210>  22
<211>  415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL nucl VR7272

<400>  22
aagcttcgaa gccaccatgg acacgagggc ccccactcag ctgctggggc tcctgctgct       60

ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgtggaggt      120

agctgtggga gacactgtca ccatcaagtg tcaggccagt cagagcatta gtaactactt      180

agcctggtat cagcagaaac cagggcagcc tcccaagctc ctgatctatc tggcatctac      240

tctggcatct ggggtcccat cgcggttcaa aggcagtgga tctgggacag agttcactct      300

caccatcagc gacctggagt gtgccgatgc tgccacttac tattgtcaac agggttatat      360

tgataatgtt aataaaggtt tcggcggagg gaccgaggtg gtggtcaaac gtacg           415


