序列表

<110>  张喜田
       孙非
       张欣

<120>  抗表皮生长因子受体的抗原结合蛋白及其应用

<130>  0195-PA-001

<160>  77

<170>  PatentIn version 3.5

<210>  1
<211>  1389
<212>  DNA
<213>  Mus musculus

<400>  1
atggctgtcc tggcgctact cctctgcctg gtgactttcc caagctgtgc cctgtcccag        60
gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcaca       120
tgcactgtct ctgggttctc attaaccagc tatgctataa actgggttcg ccagccacca       180
ggaaagggtc tggagtggct tggagtaata tggactggtg gaggcacaaa ttataattca       240
gctctcaaat ccagactgag catcagcaaa gacaactcca agagtcaagt tttcttaaaa       300
atgaacagtc tgcaaactga tgacacagcc aggtactact gtgccaggtc ctactatact       360
aacccttggt acttcgatgt ctggggcaca gggaccacgg tcaccgtctc ctcagccaaa       420
acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg       480
gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac       540
tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac       600
actctgagca gctcagtgac tgtcccctcc agcacctggc ccagccagac cgtcacctgc       660
aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt       720
ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca       780
aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac       840
atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac       900
acagctcaga cgaaaccccg ggaggagcag atcaacagca ctttccgttc agtcagtgaa       960
cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt      1020
gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct      1080
ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg      1140
acctgcatga taacaaactt cttccctgaa gacattactg tggagtggca gtggaatggg      1200
cagccagcgg agaactacaa gaacactcag cccatcatgg acacagatgg ctcttacttc      1260
gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc      1320
tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct      1380
ggtaaatga                                                              1389

<210>  2
<211>  705
<212>  DNA
<213>  Mus musculus

<400>  2
atggaatcac agactctggt cttcatatcc atactgctct ggttatatgg tgctgatggg        60
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagggtcacc       120
ttgagctgca aggccagtga gaatgtgggt aattatgtat cctggtatca acagaaagca       180
gaccagtctc ctaaactgct gatatacggg gcatccaacc ggtacactgg ggtccccgat       240
cgcttcacag gcagtggatt tgaaacagat ttcattctga ccatcgccag tgtgcaggct       300
gaagaccttg cagattatca ctgtggacag agttacagct atccattcac gttcggctcg       360
gggacaaagt tgaaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca       420
tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac       480
cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg       540
aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg       600
ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca       660
tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                       705

<210>  3
<211>  462
<212>  PRT
<213>  Mus musculus

<400>  3
Met Ala Val Leu Ala Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      
Ala Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              
Thr Ser Tyr Ala Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Leu Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  
Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Ser Tyr Tyr Thr Asn Pro Trp Tyr Phe Asp Val Trp 
        115                 120                 125             
Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 
Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             
Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 
Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     
Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         
Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             
Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 
Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 
Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     
Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         
Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             
Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 
Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 
Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                405                 410                 415     
Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         
Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             
Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460         

<210>  4
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  4
Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      
Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          
Met Ser Val Gly Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn 
        35                  40                  45              
Val Gly Asn Tyr Val Ser Trp Tyr Gln Gln Lys Ala Asp Gln Ser Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  
Arg Phe Thr Gly Ser Gly Phe Glu Thr Asp Phe Ile Leu Thr Ile Ala 
                85                  90                  95      
Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr 
            100                 105                 110         
Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Lys Arg 
        115                 120                 125             
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 

<210>  5
<211>  1398
<212>  DNA
<213>  Mus musculus

<400>  5
atgaactttg ggctcagatt gattttcctt gtccttactt taaaaggtgt gaagtgtgaa        60
gtgcaggtgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc       120
tgtgcagcct ctggattcgc tttcagtaac tatgacatgt cttgggttcg acagactccg       180
gagaagaggc tggagtgggt cgcatacatt agtagtggtg gtagtagtac ccactatcga       240
gacattgtga agggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg       300
caaatgagca gtctgaagtc tgaggacaca gccatgtatt actgtgtaag acataagagg       360
gccaactggg acctcgatgc tatggactac tggggtcaag gaacctcagt caccgtctcc       420
tcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc tgcccaaact       480
aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc agtgacagtg       540
acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt cctgcagtct       600
gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc cagcgagacc       660
gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa aattgtgccc       720
agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc tgtcttcatc       780
ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt cacgtgtgtt       840
gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt agatgatgtg       900
gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac tttccgctca       960
gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagtt caaatgcagg      1020
gtcaacagtg cagctttccc tgcccccatc gagaaaacca tctccaaaac caaaggcaga      1080
ccgaaggctc cacaggtgta caccattcca cctcccaagg agcagatggc caaggataaa      1140
gtcagtctga cctgcatgat aacagacttc ttccctgaag acattactgt ggagtggcag      1200
tggaatgggc agccagcgga gaactacaag aacactcagc ccatcatgga cacagatggc      1260
tcttacttcg tctacagcaa gctcaatgtg cagaagagca actgggaggc aggaaatact      1320
ttcacctgct ctgtgttaca tgagggcctg cacaaccacc atactgagaa gagcctctcc      1380
cactctcctg gtaaatga                                                    1398

<210>  6
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  6
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc tagcagtgat        60
gttttgctga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc       120
tcttgcagat ctagtcagaa cattgtacat agtaatggag acacctattt agaatggtac       180
ctgctgaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct       240
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caggatcagc       300
agagtggagg ctgaagatct gggagtttat tactgctttc aaagttcaca tgttccgtgg       360
acgttcggtg gaggcaccac gctggaaatc aaacgggctg atgctgcacc aactgtatcc       420
atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg       480
aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa       540
aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc       600
agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc       660
actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgttag          717

<210>  7
<211>  465
<212>  PRT
<213>  Mus musculus

<400>  7
Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Thr Leu Lys Gly 
1               5                   10                  15      
Val Lys Cys Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
        35                  40                  45              
Ser Asn Tyr Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  
Glu Trp Val Ala Tyr Ile Ser Ser Gly Gly Ser Ser Thr His Tyr Arg 
65                  70                  75                  80  
Asp Ile Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      
Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         
Tyr Tyr Cys Val Arg His Lys Arg Ala Asn Trp Asp Leu Asp Ala Met 
        115                 120                 125             
Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
    130                 135                 140                 
Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
145                 150                 155                 160 
Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
                165                 170                 175     
Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
        195                 200                 205             
Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
    210                 215                 220                 
Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
225                 230                 235                 240 
Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
                245                 250                 255     
Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
            260                 265                 270         
Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
        275                 280                 285             
Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
    290                 295                 300                 
Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
305                 310                 315                 320 
Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     
Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
            340                 345                 350         
Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
        355                 360                 365             
Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
    370                 375                 380                 
Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
385                 390                 395                 400 
Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
                405                 410                 415     
Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
            420                 425                 430         
Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
        435                 440                 445             
Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
    450                 455                 460                 
Lys 
465 

<210>  8
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  8
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              
Val His Ser Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         
Phe Gln Ser Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu 
        115                 120                 125             
Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     
Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             
Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 
Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             

<210>  9
<211>  1395
<212>  DNA
<213>  Mus musculus

<400>  9
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag        60
gtccagctgc aacaatctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc       120
tgtaaggctt ctggatacac gttcactgac tactacatga actgggtgaa acagagccat       180
ggaaagagcc ttgagtggat tggagatatt aatcctaaca atggtggtac taactacaac       240
cagaagttca agggcaaggc cacattgact gtagacaagt cctccagcac agcctccatg       300
gagctccgca gcctgacatc tgaggactct gcagtctatt actgtgcaag agggatttac       360
tacggtagtg gagcctggtt tgcttgctgg ggccaaggga ctctggtcac tgtctctgca       420
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac       480
tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc       540
tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac       600
ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag ccagaccgtc       660
acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg       720
gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc       780
cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg       840
gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag       900
gtgcacacag ctcagacgaa accccgggag gagcagatca acagcacttt ccgttcagtc       960
agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      1020
aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg      1080
aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc      1140
agtctgacct gcatgataac aaacttcttc cctgaagaca ttactgtgga gtggcagtgg      1200
aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct      1260
tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc      1320
acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac      1380
tctcctggta aatga                                                       1395

<210>  10
<211>  705
<212>  DNA
<213>  Mus musculus

<400>  10
atgaagtcac agacccaggt cttcgtattt ctactgctct gtgtgtctgg tgctcatggg        60
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       120
ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca       180
gggcagtctc ctaaactgct gatatactat gcatccaatc gctacactgg agtccctgat       240
cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct       300
gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga       360
ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca       420
tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac       480
cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg       540
aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg       600
ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca       660
tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gttag                       705

<210>  11
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  11
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      
Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      
Thr Ala Ser Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Ile Tyr Tyr Gly Ser Gly Ala Trp Phe Ala 
        115                 120                 125             
Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr 
    130                 135                 140                 
Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 
Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             
Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val 
    210                 215                 220                 
Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 
Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     
Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         
Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             
Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 
Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 
Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     
Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         
Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             
Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 
Met Ile Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 
Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     
Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         
Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             
Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 

<210>  12
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  12
Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu 
            20                  25                  30          
Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  
Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         
Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  13
<211>  92
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  EGFR的II结构域(氨基酸Ser196-Cys287)

<400>  13

Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln 
1               5                   10                  15      


Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys 
            20                  25                  30          


Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu 
        35                  40                  45              


Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly 
    50                  55                  60                  


Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr 
65                  70                  75                  80  


Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys 
                85                  90          


<210>  14
<211>  111
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LZ-8

<400>  14

Met Ser Asp Thr Ala Leu Ile Phe Arg Leu Ala Trp Asp Val Lys Lys 
1               5                   10                  15      


Leu Ser Phe Asp Tyr Thr Pro Asn Trp Gly Arg Gly Asn Pro Asn Asn 
            20                  25                  30          


Phe Ile Asp Thr Val Thr Phe Pro Lys Val Leu Thr Asp Lys Ala Tyr 
        35                  40                  45              


Thr Tyr Arg Val Ala Val Ser Gly Arg Asn Leu Gly Val Lys Pro Ser 
    50                  55                  60                  


Tyr Ala Val Glu Ser Asp Gly Ser Gln Lys Val Asn Phe Leu Glu Tyr 
65                  70                  75                  80  


Asn Ser Gly Tyr Gly Ile Ala Asp Thr Asn Thr Ile Gln Val Phe Val 
                85                  90                  95      


Val Asp Pro Asp Thr Asn Asn Asp Phe Ile Ile Ala Gln Trp Asn 
            100                 105                 110     


<210>  15
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 HCDR1

<400>  15

Ser Tyr Ala Ile Asn 
1               5   


<210>  16
<211>  16
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 HCDR2

<400>  16

Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  17
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 HCDR3

<400>  17

Ser Tyr Tyr Thr Asn Pro Trp Tyr Phe Asp Val 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 LCDR1

<400>  18

Lys Ala Ser Glu Asn Val Gly Asn Tyr Val Ser 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 LCDR2

<400>  19

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 LCDR3

<400>  20

Gly Gln Ser Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  21
<211>  30
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 H-FR1

<400>  21

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  22
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 H-FR2

<400>  22

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  23
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 H-FR3

<400>  23

Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
1               5                   10                  15      


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  24
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 H-FR4

<400>  24

Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  25
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 L-FR1

<400>  25

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys 
            20              


<210>  26
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 L-FR2

<400>  26

Trp Tyr Gln Gln Lys Ala Asp Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  27
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 L-FR3

<400>  27

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Phe Glu Thr Asp Phe Ile 
1               5                   10                  15      


Leu Thr Ile Ala Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys 
            20                  25                  30          


<210>  28
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 L-FR4

<400>  28

Phe Gly Ser Gly Thr Lys Leu Lys Ile Lys 
1               5                   10  


<210>  29
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 HCDR1

<400>  29

Asn Tyr Asp Met Ser 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 HCDR2

<400>  30

Tyr Ile Ser Ser Gly Gly Ser Ser Thr His Tyr Arg Asp Ile Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  13
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 HCDR3

<400>  31

His Lys Arg Ala Asn Trp Asp Leu Asp Ala Met Asp Tyr 
1               5                   10              


<210>  32
<211>  16
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 LCDR1

<400>  32

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  33
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 LCDR2

<400>  33

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 LCDR3

<400>  34

Phe Gln Ser Ser His Val Pro Trp Thr 
1               5                   


<210>  35
<211>  30
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 H-FR1

<400>  35

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser 
            20                  25                  30  


<210>  36
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 H-FR2

<400>  36

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  37
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 H-FR3

<400>  37

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  38
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 H-FR4

<400>  38

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  39
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 L-FR1

<400>  39

Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  40
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 L-FR2

<400>  40

Trp Tyr Leu Leu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  41
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 L-FR3

<400>  41

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  42
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 L-FR4

<400>  42

Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
1               5                   10  


<210>  43
<211>  5
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 HCDR1

<400>  43

Asp Tyr Tyr Met Asn 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 HCDR2

<400>  44

Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 HCDR3

<400>  45

Gly Ile Tyr Tyr Gly Ser Gly Ala Trp Phe Ala Cys 
1               5                   10          


<210>  46
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 LCDR1

<400>  46

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 LCDR2

<400>  47

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 LCDR3

<400>  48

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  49
<211>  30
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 H-FR1

<400>  49

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  50
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 H-FR2

<400>  50

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  51
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 H-FR3

<400>  51

Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Ser Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  52
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 H-FR4

<400>  52

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  53
<211>  23
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 L-FR1

<400>  53

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  54
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 L-FR2

<400>  54

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  55
<211>  32
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 L-FR3

<400>  55

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  56
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 L-FR4

<400>  56

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  57
<211>  324
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4、6F2重链恒定区

<400>  57

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  58
<211>  324
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1重链恒定区

<400>  58

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  59
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  轻链恒定区

<400>  59

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  60
<211>  443
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4重链

<400>  60

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Tyr Thr Asn Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
    210                 215                 220                 


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
            260                 265                 270         


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
    290                 295                 300                 


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
305                 310                 315                 320 


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
            340                 345                 350         


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe 
        355                 360                 365             


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
    370                 375                 380                 


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
                405                 410                 415     


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440             


<210>  61
<211>  214
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4轻链

<400>  61

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Asn Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Ala Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Glu Thr Asp Phe Ile Leu Thr Ile Ala Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  62
<211>  446
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1重链

<400>  62

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Ser Ser Thr His Tyr Arg Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Lys Arg Ala Asn Trp Asp Leu Asp Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  63
<211>  219
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1轻链

<400>  63

Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  64
<211>  445
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2重链

<400>  64

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Tyr Tyr Gly Ser Gly Ala Trp Phe Ala Cys Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
    210                 215                 220                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    290                 295                 300                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
305                 310                 315                 320 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            340                 345                 350         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        355                 360                 365             


Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    370                 375                 380                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                405                 410                 415     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445 


<210>  65
<211>  214
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2轻链

<400>  65

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  66
<211>  357
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 VH 核苷酸序列

<400>  66
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taaactgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta atatggactg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag gtcctactat      300

actaaccctt ggtacttcga tgtctggggc acagggacca cggtcaccgt ctcctca         357


<210>  67
<211>  321
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 VL 核苷酸序列

<400>  67
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagggtcacc       60

ttgagctgca aggccagtga gaatgtgggt aattatgtat cctggtatca acagaaagca      120

gaccagtctc ctaaactgct gatatacggg gcatccaacc ggtacactgg ggtccccgat      180

cgcttcacag gcagtggatt tgaaacagat ttcattctga ccatcgccag tgtgcaggct      240

gaagaccttg cagattatca ctgtggacag agttacagct atccattcac gttcggctcg      300

gggacaaagt tgaaaataaa a                                                321


<210>  68
<211>  119
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 VH

<400>  68

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Tyr Thr Asn Pro Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  1Z4 VL

<400>  69

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Asn Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Ala Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Glu Thr Asp Phe Ile Leu Thr Ile Ala Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Lys Ile Lys 
            100                 105         


<210>  70
<211>  366
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 VH 核苷酸序列

<400>  70
gaagtgcagg tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cgctttcagt aactatgaca tgtcttgggt tcgacagact      120

ccggagaaga ggctggagtg ggtcgcatac attagtagtg gtggtagtag tacccactat      180

cgagacattg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgt aagacataag      300

agggccaact gggacctcga tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  71
<211>  336
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 VL 核苷酸序列

<400>  71
gatgttttgc tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattgta catagtaatg gagacaccta tttagaatgg      120

tacctgctga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaggatc      240

agcagagtgg aggctgaaga tctgggagtt tattactgct ttcaaagttc acatgttccg      300

tggacgttcg gtggaggcac cacgctggaa atcaaa                                336


<210>  72
<211>  122
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 VH

<400>  72

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Ser Ser Thr His Tyr Arg Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg His Lys Arg Ala Asn Trp Asp Leu Asp Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  73
<211>  112
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  4B1 VL

<400>  73

Asp Val Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
            100                 105                 110         


<210>  74
<211>  363
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 VH 核苷酸序列

<400>  74
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaaacagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactaactac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctcc      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagagggatt      300

tactacggta gtggagcctg gtttgcttgc tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  75
<211>  321
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 VL 核苷酸序列

<400>  75
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaactgct gatatactat gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  76
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 VH

<400>  76

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Tyr Tyr Gly Ser Gly Ala Trp Phe Ala Cys Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  77
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  6F2 VL

<400>  77

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

