                         б

<110>  ҽҩƼ޹˾
 
<120>  ǶϿԭŻ

<130>  C20P0149PR

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR4-1BB̼ź

<400>  1
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc      120

gagctg                                                                 126


<210>  2
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR4-1BB̼ź

<400>  2

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  3
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B5̼ź

<400>  3
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgcagctgc cgcttccccg agcaggagga gggcggctgc      120

gagctg                                                                 126


<210>  4
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B5̼ź(E35Q)

<400>  4

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  5
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B6̼ź

<400>  5
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

cccaccgagg aggaggacgg ctgcagctgc cgcttcaccg agcaggagga gggcggctgc      120

gagctg                                                                 126


<210>  6
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B6̼ź(T21PQ23EP33TE35Q)

<400>  6

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Pro Thr Glu Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Thr Glu Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  7
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B7̼ź

<400>  7
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgttc       60

cccgaggagg aggaggacgg ctgcagctgc cgccagacca cccaggagga gggcggctgc      120

gagctg                                                                 126


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B7̼ź(Q20FT21PT22EQ23EF32QP33TE34TE35Q)

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Phe Pro Glu Glu Glu Glu Asp Gly Cys Ser Cys Arg Gln 
            20                  25                  30          


Thr Thr Gln Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B8̼ź

<400>  9
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc      120

gagctggtgc agaccaccca ggaggaggac ggctgcagc                             159


<210>  10
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B8̼ź(C˲4-1BB)

<400>  10

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Phe Pro Glu Glu Glu 
        35                  40                  45              


Glu Gly Gly Cys Glu 
    50              


<210>  11
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B9̼ź

<400>  11
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc      120

gagctgcgct tccccgagga ggaggagggc ggctgcgag                             159


<210>  12
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B9̼ź(C˲4-1BB)

<400>  12

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Val Gln Thr Thr Gln Glu 
        35                  40                  45              


Glu Asp Gly Cys Ser 
    50              


<210>  13
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B11̼ź

<400>  13
aagcgcggcc gcaagaagct gctgtacatc ttcaagcagc ccttcatgcg ccccgtgcag       60

accacccagg aggaggacgg ctgcagctgc cgcttccccg aggaggagga gggcggctgc      120

gagctggacc tggcgatggc tgacttggag cagaaggtc                             159


<210>  14
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR-B11̼ź(C˲TRAF2)

<400>  14

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Asp Leu Ala Met Ala Asp 
        35                  40                  45              


Leu Glu Gln Lys Val 
    50              


<210>  15
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BCMA CAR

<400>  15
atgctgctgc tggtgaccag cctgctgctg tgtgagttac cacacccagc attcctcctg       60

atcccagaca ttgtgctcac tcagtcacct cccagcctgg ccatgagcct gggaaaaagg      120

gccaccatct cctgtagagc cagtgagtcc gtcacaatct tggggagcca tcttattcac      180

tggtatcagc agaagcccgg gcagcctcca acccttctta ttcagctcgc gtcaaacgtc      240

cagacgggtg tacctgccag attttctggt agcgggtccc gcactgattt tacactgacc      300

atagatccag tggaagaaga cgatgtggcc gtgtattatt gtctgcagag cagaacgatt      360

cctcgcacat ttggtggggg tactaagctg gagattaagg gaagcacgtc cggctcaggg      420

aagccgggct ccggcgaggg aagcacgaag gggcaaattc agctggtcca gagcggacct      480

gagctgaaaa aacccggcga gactgttaag atcagttgta aagcatctgg ctataccttc      540

accgactaca gcataaattg ggtgaaacgg gcccctggaa agggcctcaa atggatgggt      600

tggatcaata ccgaaactag ggagcctgct tatgcatatg acttccgcgg gagattcgcc      660

ttttcactcg agacatctgc ctctactgct tacctccaaa taaacaacct caagtatgaa      720

gatacagcca cttacttttg cgccctcgac tatagttacg ccatggacta ctggggacag      780

ggaacctccg ttaccgtcag ttccaccacc accccagccc cccgaccacc aacacccgcc      840

cccaccatcg ccagccagcc cctgagcctg cgccccgagg cctgccgccc cgccgccggc      900

ggcgccgtgc acacccgcgg cctggacttc gcctgcgaca tctacatctg ggcccccctg      960

gccggcacct gcggcgtgct gctgctgagc ctggtgatca ccctgtactg caagcgcggc     1020

cgcaagaagc tgctgtacat cttcaagcag cccttcatgc gccccgtgca gaccacccag     1080

gaggaggacg gctgcagctg ccgcttcccc gaggaggagg agggcggctg cgagctgcgc     1140

gtgaagttca gccgcagcgc cgacgccccc gcctacaagc agggccagaa ccagctgtac     1200

aacgagctga acctgggccg ccgcgaggag tacgacgtgc tggacaagcg ccgcggccgc     1260

gaccccgaga tgggcggcaa gccccgccgc aagaaccccc aggagggcct gtacaacgag     1320

ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcgccgc     1380

cgcggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggacacctac     1440

gacgccctgc acatgcaggc cctgcccccc cgctaa                               1476


<210>  16
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCMA CAR

<400>  16

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser 
            20                  25                  30          


Leu Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val 
65                  70                  75                  80  


Gln Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro 
145                 150                 155                 160 


Glu Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu 
        195                 200                 205             


Pro Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu 
    210                 215                 220                 


Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu 
225                 230                 235                 240 


Asp Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     