                               SEQUENCE LISTING

<110> DIADEM BIOTHERAPEUTICS INC.
 
<120> ARTIFICIAL SYNAPSES

<130> 085172-000001WO00

<140> PCT/US2021/016949
<141> 2021-02-05

<150> 62/970,374
<151> 2020-02-05

<160> 319   

<170> PatentIn version 3.5

<210> 1
<211> 3634
<212> DNA
<213> Homo sapiens

<400> 1
agttctgcgc agcttcccga ggctccgcac cagccgcgct tctgtccgcc tgcagggcat       60

tccagaaaga tgaggatatt tgctgtcttt atattcatga cctactggca tttgctgaac      120

gcatttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca      180

attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg      240

gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag      300

catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct      360

gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc      420

tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc      480

aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct      540

gagggctacc ccaaggccga agtcatctgg acaagcagtg accatcaagt cctgagtggt      600

aagaccacca ccaccaattc caagagagag gagaagcttt tcaatgtgac cagcacactg      660

agaatcaaca caacaactaa tgagattttc tactgcactt ttaggagatt agatcctgag      720

gaaaaccata cagctgaatt ggtcatccca gaactacctc tggcacatcc tccaaatgaa      780

aggactcact tggtaattct gggagccatc ttattatgcc ttggtgtagc actgacattc      840

atcttccgtt taagaaaagg gagaatgatg gatgtgaaaa aatgtggcat ccaagataca      900

aactcaaaga agcaaagtga tacacatttg gaggagacgt aatccagcat tggaacttct      960

gatcttcaag cagggattct caacctgtgg tttaggggtt catcggggct gagcgtgaca     1020

agaggaagga atgggcccgt gggatgcagg caatgtggga cttaaaaggc ccaagcactg     1080

aaaatggaac ctggcgaaag cagaggagga gaatgaagaa agatggagtc aaacagggag     1140

cctggaggga gaccttgata ctttcaaatg cctgaggggc tcatcgacgc ctgtgacagg     1200

gagaaaggat acttctgaac aaggagcctc caagcaaatc atccattgct catcctagga     1260

agacgggttg agaatcccta atttgagggt cagttcctgc agaagtgccc tttgcctcca     1320

ctcaatgcct caatttgttt tctgcatgac tgagagtctc agtgttggaa cgggacagta     1380

tttatgtatg agtttttcct atttattttg agtctgtgag gtcttcttgt catgtgagtg     1440

tggttgtgaa tgatttcttt tgaagatata ttgtagtaga tgttacaatt ttgtcgccaa     1500

actaaacttg ctgcttaatg atttgctcac atctagtaaa acatggagta tttgtaaggt     1560

gcttggtctc ctctataact acaagtatac attggaagca taaagatcaa accgttggtt     1620

gcataggatg tcacctttat ttaacccatt aatactctgg ttgacctaat cttattctca     1680

gacctcaagt gtctgtgcag tatctgttcc atttaaatat cagctttaca attatgtggt     1740

agcctacaca cataatctca tttcatcgct gtaaccaccc tgttgtgata accactatta     1800

ttttacccat cgtacagctg aggaagcaaa cagattaagt aacttgccca aaccagtaaa     1860

tagcagacct cagactgcca cccactgtcc ttttataata caatttacag ctatatttta     1920

ctttaagcaa ttcttttatt caaaaaccat ttattaagtg cccttgcaat atcaatcgct     1980

gtgccaggca ttgaatctac agatgtgagc aagacaaagt acctgtcctc aaggagctca     2040

tagtataatg aggagattaa caagaaaatg tattattaca atttagtcca gtgtcatagc     2100

ataaggatga tgcgagggga aaacccgagc agtgttgcca agaggaggaa ataggccaat     2160

gtggtctggg acggttggat atacttaaac atcttaataa tcagagtaat tttcatttac     2220

aaagagaggt cggtacttaa aataaccctg aaaaataaca ctggaattcc ttttctagca     2280

ttatatttat tcctgatttg cctttgccat ataatctaat gcttgtttat atagtgtctg     2340

gtattgttta acagttctgt cttttctatt taaatgccac taaattttaa attcatacct     2400

ttccatgatt caaaattcaa aagatcccat gggagatggt tggaaaatct ccacttcatc     2460

ctccaagcca ttcaagtttc ctttccagaa gcaactgcta ctgcctttca ttcatatgtt     2520

cttctaaaga tagtctacat ttggaaatgt atgttaaaag cacgtatttt taaaattttt     2580

ttcctaaata gtaacacatt gtatgtctgc tgtgtacttt gctattttta tttattttag     2640

tgtttcttat atagcagatg gaatgaattt gaagttccca gggctgagga tccatgcctt     2700

ctttgtttct aagttatctt tcccatagct tttcattatc tttcatatga tccagtatat     2760

gttaaatatg tcctacatat acatttagac aaccaccatt tgttaagtat ttgctctagg     2820

acagagtttg gatttgttta tgtttgctca aaaggagacc catgggctct ccagggtgca     2880

ctgagtcaat ctagtcctaa aaagcaatct tattattaac tctgtatgac agaatcatgt     2940

ctggaacttt tgttttctgc tttctgtcaa gtataaactt cactttgatg ctgtacttgc     3000

aaaatcacat tttctttctg gaaattccgg cagtgtacct tgactgctag ctaccctgtg     3060

ccagaaaagc ctcattcgtt gtgcttgaac ccttgaatgc caccagctgt catcactaca     3120

cagccctcct aagaggcttc ctggaggttt cgagattcag atgccctggg agatcccaga     3180

gtttcctttc cctcttggcc atattctggt gtcaatgaca aggagtacct tggctttgcc     3240

acatgtcaag gctgaagaaa cagtgtctcc aacagagctc cttgtgttat ctgtttgtac     3300

atgtgcattt gtacagtaat tggtgtgaca gtgttctttg tgtgaattac aggcaagaat     3360

tgtggctgag caaggcacat agtctactca gtctattcct aagtcctaac tcctccttgt     3420

ggtgttggat ttgtaaggca ctttatccct tttgtctcat gtttcatcgt aaatggcata     3480

ggcagagatg atacctaatt ctgcatttga ttgtcacttt ttgtacctgc attaatttaa     3540

taaaatattc ttatttattt tgttacttgg tacaccagca tgtccatttt cttgtttatt     3600

ttgtgtttaa taaaatgttc agtttaacat ccca                                 3634


<210> 2
<211> 290
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 3
<211> 3653
<212> DNA
<213> Mus musculus

<400> 3
gaaatcgtgg tccccaagcc tcatgccagg ctgcacttgc acgtcgcggg ccagtctcct       60

cgcctgcaga tagttcccaa aacatgagga tatttgctgg cattatattc acagcctgct      120

gtcacttgct acgggcgttt actatcacgg ctccaaagga cttgtacgtg gtggagtatg      180

gcagcaacgt cacgatggag tgcagattcc ctgtagaacg ggagctggac ctgcttgcgt      240

tagtggtgta ctgggaaaag gaagatgagc aagtgattca gtttgtggca ggagaggagg      300

accttaagcc tcagcacagc aacttcaggg ggagagcctc gctgccaaag gaccagcttt      360

tgaagggaaa tgctgccctt cagatcacag acgtcaagct gcaggacgca ggcgtttact      420

gctgcataat cagctacggt ggtgcggact acaagcgaat cacgctgaaa gtcaatgccc      480

cataccgcaa aatcaaccag agaatttccg tggatccagc cacttctgag catgaactaa      540

tatgtcaggc cgagggttat ccagaagctg aggtaatctg gacaaacagt gaccaccaac      600

ccgtgagtgg gaagagaagt gtcaccactt cccggacaga ggggatgctt ctcaatgtga      660

ccagcagtct gagggtcaac gccacagcga atgatgtttt ctactgtacg ttttggagat      720

cacagccagg gcaaaaccac acagcggagc tgatcatccc agaactgcct gcaacacatc      780

ctccacagaa caggactcac tgggtgcttc tgggatccat cctgttgttc ctcattgtag      840

tgtccacggt cctcctcttc ttgagaaaac aagtgagaat gctagatgtg gagaaatgtg      900

gcgttgaaga tacaagctca aaaaaccgaa atgatacaca attcgaggag acgtaagcag      960

tgttgaaccc tctgatcgtc gattggcagc ttgtggtctg tgaaagaaag ggcccatggg     1020

acatgagtcc aaagactcaa gatggaacct gagggagaga accaagaaag tgttgggaga     1080

ggagcctgga acaacggaca ttttttccag ggagacactg ctaagcaagt tgcccatcag     1140

tcgtcttggg aaatggattg agggttcctg gcttagcagc tggtccttgc acagtgacct     1200

tttcctctgc tcagtgccgg gatgagagat ggagtcatga gtgttgaaga ataagtgcct     1260

tctatttatt ttgagtctgt gtgttctcac tttgggcatg taattatgac tggtgaattc     1320

tgacgacatg atagatctta agatgtagtc accaaactca actgctgctt agcatcctcc     1380

gtaactactg atacaagcag ggaacacaga ggtcacctgc ttggtttgac aggctcttgc     1440

tgtctgactc aaataatctt tatttttcag tcctcaaggc tcttcgatag cagttgttct     1500

gtatcagcct tataggtgtc aggtatagca ctcaacatct catctcatta caatagcaac     1560

cctcatcacc atagcaacag ctaacctctg ttatcctcac ttcatagcca ggaagctgag     1620

cgactaagtc acttgcccac agagtatcag ctctcagatt tctgttcttc agccactgtc     1680

ctttcaggat agaatttgtc gttaagaaat taatttaaaa actgattatt gagtagcatt     1740

gtatatcaat cacaacatgc cttgtgcact gtgctggcct ctgagcataa agatgtacgc     1800

cggagtaccg gtcggacatg tttatgtgtg ttaaatactc agagaaatgt tcattaacaa     1860

ggagcttgca ttttagagac actggaaagt aactccagtt cattgtctag cattacattt     1920

acctcatttg ctatccttgc catacagtct cttgttctcc atgaagtgtc atgaatcttg     1980

ttgaatagtt cttttatttt ttaaatgttt ctatttaaat gatattgaca tctgaggcga     2040

tagctcagtt ggtaaaaccc tttcctcaca agtgtgaaac cctgagtctt atccctagaa     2100

cccacataaa aaacagttgc gtatgtttgt gcatgctttt gatcccagca ctagggaggc     2160

agaggcaggc agatcctgag ctctcattga ccacccagcc tagcctacat ggttagctcc     2220

aggcctacag gagctggcag agcctgaaaa acgatgccta gacacacaca cacacacaca     2280

cacacacaca cacacacaca cacaccatgt actcatagac ctaagtgcac cctcctacac     2340

atgcacacac atacaattca aacacaaatc aacagggaat tgtctcagaa tggtccccaa     2400

gacaaagaag aagaaaaaca ccaaaccagc tctattccct cagcctatcc tctctactcc     2460

ttcctagaag caactactat tgtttttgta tataaattta cccaacgaca gttaatatgt     2520

agaatatata ttaaagtgtc tgtcaatata tattatctct ttctttcttt cttcctttct     2580

ttctttcttt ctttctttct ttctttcttt ctttctttct ttcttccttc cttccttcct     2640

tccttccttc cttccttcct ttctttcttt ctttcttttt ttctgtctat ctgtacctaa     2700

atggttgctc actatgcatt ttctgtgctc ttcgcccttt ttatttaatg tatggatatt     2760

tatgctgctt ccagaatgga tctaaagctc tttgtttcta ggttttctcc cccatccttc     2820

taggcatctc tcacactgtc taggccagac accatgtctg ctgcctgaat ctgtagacac     2880

catttataaa gcacgtactc accgagtttg tatttggctt gttctgtgtc tgattaaagg     2940

gagaccatga gtccccaggg tacactgagt taccccagta ccaaggggga gccttgtttg     3000

tgtctccatg gcagaagcag gcctggagcc attttggttt cttccttgac ttctctcaaa     3060

cacagacgcc tcacttgctc attacaggtt ctcctttggg aatgtcagca ttgctccttg     3120

actgctggct gccctggaag gagcccatta gctctgtgtg agcccttgac agctactgcc     3180

tctccttacc acaggggcct ctaagatact gttacctaga ggtcttgagg atctgtgttc     3240

tctgggggga ggaaaggagg aggaacccag aactttctta cagttttcct tgttctgtca     3300

catgtcaaga ctgaaggaac aggctgggct acgtagtgag atcctgtctc aaaggaaaga     3360

cgagcatagc cgaacccccg gtggaacccc ctctgttacc tgttcacaca agcttattga     3420

tgagtctcat gttaatgtct tgtttgtatg aagtttaaga aaatatcggg ttgggcaaca     3480

cattctattt attcatttta tttgaaatct taatgccatc tcatggtgtt ggattggtgt     3540

ggcactttat tcttttgtgt tgtgtataac cataaatttt attttgcatc agattgtcaa     3600

tgtattgcat taatttaata aatattttta tttattaaaa aaaaaaaaaa aaa            3653


<210> 4
<211> 290
<212> PRT
<213> Mus musculus

<400> 4
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr His Trp 
225                 230                 235                 240 


Val Leu Leu Gly Ser Ile Leu Leu Phe Leu Ile Val Val Ser Thr Val 
                245                 250                 255     


Leu Leu Phe Leu Arg Lys Gln Val Arg Met Leu Asp Val Glu Lys Cys 
            260                 265                 270         


Gly Val Glu Asp Thr Ser Ser Lys Asn Arg Asn Asp Thr Gln Phe Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 5
<211> 2432
<212> DNA
<213> Homo sapiens

<400> 5
actctcatgt tacggcaaac cttaagctga atgaacaact tttcttctct tgaatatatc       60

ttaacgccaa attttgagtg cttttttgtt acccatcctc atatgtccca gctagaaaga      120

atcctgggtt ggagctactg catgttgatt gttttgtttt tccttttggc tgttcatttt      180

ggtggctact ataaggaaat ctaacacaaa cagcaactgt tttttgttgt ttacttttgc      240

atctttactt gtggagctgt ggcaagtcct catatcaaat acagaacatg atcttcctcc      300

tgctaatgtt gagcctggaa ttgcagcttc accagatagc agctttattc acagtgacag      360

tccctaagga actgtacata atagagcatg gcagcaatgt gaccctggaa tgcaactttg      420

acactggaag tcatgtgaac cttggagcaa taacagccag tttgcaaaag gtggaaaatg      480

atacatcccc acaccgtgaa agagccactt tgctggagga gcagctgccc ctagggaagg      540

cctcgttcca catacctcaa gtccaagtga gggacgaagg acagtaccaa tgcataatca      600

tctatggggt cgcctgggac tacaagtacc tgactctgaa agtcaaagct tcctacagga      660

aaataaacac tcacatccta aaggttccag aaacagatga ggtagagctc acctgccagg      720

ctacaggtta tcctctggca gaagtatcct ggccaaacgt cagcgttcct gccaacacca      780

gccactccag gacccctgaa ggcctctacc aggtcaccag tgttctgcgc ctaaagccac      840

cccctggcag aaacttcagc tgtgtgttct ggaatactca cgtgagggaa cttactttgg      900

ccagcattga ccttcaaagt cagatggaac ccaggaccca tccaacttgg ctgcttcaca      960

ttttcatccc cttctgcatc attgctttca ttttcatagc cacagtgata gccctaagaa     1020

aacaactctg tcaaaagctg tattcttcaa aagacacaac aaaaagacct gtcaccacaa     1080

caaagaggga agtgaacagt gctatctgaa cctgtggtct tgggagccag ggtgacctga     1140

tatgacatct aaagaagctt ctggactctg aacaagaatt cggtggcctg cagagcttgc     1200

catttgcact tttcaaatgc ctttggatga cccagcactt taatctgaaa cctgcaacaa     1260

gactagccaa cacctggcca tgaaacttgc cccttcactg atctggactc acctctggag     1320

cctatggctt taagcaagca ctactgcact ttacagaatt accccactgg atcctggacc     1380

cacagaattc cttcaggatc cttcttgctg ccagactgaa agcaaaagga attatttccc     1440

ctcaagtttt ctaagtgatt tccaaaagca gaggtgtgtg gaaatttcca gtaacagaaa     1500

cagatgggtt gccaatagag ttatttttta tctatagctt cctctgggta ctagaagagg     1560

ctattgagac tatgagctca cagacagggc ttcgcacaaa ctcaaatcat aattgacatg     1620

ttttatggat tactggaatc ttgatagcat aatgaagttg ttctaattaa cagagagcat     1680

ttaaatatac actaagtgca caaattgtgg agtaaagtca tcaagctctg tttttgaggt     1740

ctaagtcaca aagcatttgt tttaacctgt aatggcacca tgtttaatgg tggttttttt     1800

tttgaactac atctttcctt taaaaattat tggtttcttt ttatttgttt ttaccttaga     1860

aatcaattat atacagtcaa aaatatttga tatgctcata cgttgtatct gcagcaattt     1920

cagataagta gctaaaatgg ccaaagcccc aaactaagcc tccttttctg gccctcaata     1980

tgactttaaa tttgactttt cagtgcctca gtttgcacat ctgtaataca gcaatgctaa     2040

gtagtcaagg cctttgataa ttggcactat ggaaatcctg caagatccca ctacatatgt     2100

gtggagcaga agggtaactc ggctacagta acagcttaat tttgttaaat ttgttcttta     2160

tactggagcc atgaagctca gagcattagc tgacccttga actattcaaa tgggcacatt     2220

agctagtata acagacttac ataggtgggc ctaaagcaag ctccttaact gagcaaaatt     2280

tggggcttat gagaatgaaa gggtgtgaaa ttgactaaca gacaaatcat acatctcagt     2340

ttctcaattc tcatgtaaat cagagaatgc ctttaaagaa taaaactcaa ttgttattct     2400

tcaacgttct ttatatattc tacttttggg ta                                   2432


<210> 6
<211> 273
<212> PRT
<213> Homo sapiens

<400> 6
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210> 7
<211> 3415
<212> DNA
<213> Mus musculus

<400> 7
gaccacatca tttttgttcc ctttgttgga tatatcctaa tgtcaaatgt ggcatatctt       60

tgttgtctcc ttctgtctcc caactagaga gaacacactt acggctcctg tcccgggcag      120

gtttggttgt cggtgtgatt ggcttccagg gaacctgata caaggagcaa ctgtgtgctg      180

ccttttctgt gtctttgctt gaggagctgt gctgggtgct gatattgaca cagaccatgc      240

tgctcctgct gccgatactg aacctgagct tacaacttca tcctgtagca gctttattca      300

ccgtgacagc ccctaaagaa gtgtacaccg tagacgtcgg cagcagtgtg agcctggagt      360

gcgattttga ccgcagagaa tgcactgaac tggaagggat aagagccagt ttgcagaagg      420

tagaaaatga tacgtctctg caaagtgaaa gagccaccct gctggaggag cagctgcccc      480

tgggaaaggc tttgttccac atccctagtg tccaagtgag agattccggg cagtaccgtt      540

gcctggtcat ctgcggggcc gcctgggact acaagtacct gacggtgaaa gtcaaagctt      600

cttacatgag gatagacact aggatcctgg aggttccagg tacaggggag gtgcagctta      660

cctgccaggc tagaggttat cccctagcag aagtgtcctg gcaaaatgtc agtgttcctg      720

ccaacaccag ccacatcagg acccccgaag gcctctacca ggtcaccagt gttctgcgcc      780

tcaagcctca gcctagcaga aacttcagct gcatgttctg gaatgctcac atgaaggagc      840

tgacttcagc catcattgac cctctgagtc ggatggaacc caaagtcccc agaacgtggc      900

cacttcatgt tttcatcccg gcctgcacca tcgctttgat cttcctggcc atagtgataa      960

tccagagaaa gaggatctag gggaagctgt attacggaag aagatctgga cctgcggtct     1020

tgggagttgg aaggatctga tgggaaaccc tcaagagact tctggactca aagtgagaat     1080

cttgcaggac ctgccatttg cacttttgaa ccctttggac ggtgacccag ggctccgaag     1140

aggagcttgt aagactgaca atcttccctc tgtctcaaga ctctctgaac agcaagaccc     1200

caatggcact ttagacttac ccctgggatc ctggacccca gtgagggcct aaggctccta     1260

atgactttca gggtgagaac aaaaggaatt gctctccgcc ccacccccac ctcctgcttt     1320

ccgcagggag acatggaaat tcccagttac taaaatagat tgtcaataga gttatttata     1380

gccctcattt cctccgggga cttggaagct tcagacaggg tttttcataa acaaagtcat     1440

aactgatgtg ttttacagca tcctagaatc ctggcagcct ctgaagttct aattaactgg     1500

aagcatttaa gcaacacgtt aagtaccccc actgtggtat ttgtttctac ttttctgttt     1560

ttaaagtgtg agtcacaagg taattgttgt aacctgtgat atcactgttt cttgtgtctc     1620

ttctttcaac tacatctttt aaaacaaaac ggtgtggggt ttggttgttt tggtggtagt     1680

ggtagtgttt ctcagtggta tctccttaag aaaaaaaatc atcatgccag tgaattgttt     1740

cttcagccat ttcagatggg aagctggaat agcctgtccc ccaagctaag ccttcttccc     1800

tagctttctg cgtgatttta cattgagcat tcctgttgct ttgtttctat aactgtaatg     1860

tggtgatgtc attgttaggg cacttgaggg tgggcgttct ggaagtcctt tcaggttagt     1920

gtttgggggc agggttgctc agaatacata aaggtgctaa cttaaactgc agccatggag     1980

ctcagtgaat tcactaacct tcgggctgtc caaatgtgca cattagctac tgtgacccct     2040

gtaggttagg gagcctgaag ccagctcttt acctggtgtt tagactcagc agaatttgga     2100

gtcaatggga ccaaatggtt gtgaaattaa gatttgaagt gtgcatctta ttttatcacc     2160

atctgcccaa caaaacttca gaaaatgcct ttgaagcaca aaaatgtaat cgtttatgtg     2220

aaatctctga gttgcattta gatgcccatt gcagcaaggt ggctctctca cagattccac     2280

accttagcct aagataccag acagcaggac agagagaaaa gtccttcctg gtgtgcaaac     2340

ttccttacac tggacctcgc ctctcaggtg tgtgattggt aggccaaatc ccgatagcca     2400

atcggtgttg ggtgctttgt ctgctctact gggagtccag tggtacaatg gattctggca     2460

aaatgctgcc atcttggccc tcgctgggct gctttctagg atattcatag agaaagggcc     2520

gtccagatcc agtatcctaa aatcctgaga ggagaatata agttagtgtg tctcactata     2580

actatctcta tgatcggtca cattactatc taacagttac caaatactat atgcctaata     2640

ctggtaagca ttttatacac accattggat tgaatcctct caaaatcctc aaaaaggaag     2700

ttattaatac ctccataggc aaggagccca gaacccagag aggtcaggca gtctagttat     2760

agatgcctgc tttgtttaga agtgaacaag agcatcaaat tattaatgtg ccctggttat     2820

taatgcgccc tggttacctg ctggatggaa catcaaggtg gacttttggc agttgcatac     2880

acccagaggt attttggcta ttcacggatt aatttcacac gaagtgtttc agagacatgt     2940

gtaggggaag tccgggttca gggggcctaa gattcaaact ctagcttagc tacgtctgac     3000

ctccctaagc actaacttac tatcaaaaga atgagcagta aaagaatggt gtttactgcc     3060

tgcctttatc aggcagtgaa cgtgcagcgg gcaacgaatg cttgataagt gtgtgtcagt     3120

gtgaagtccc atgtaccagc cgctgtcccc actgcaaaag cagcagagcg ctcagacatc     3180

atcagctgat ttaccagcag cagatttctt cttctagtcc catccctgaa gaagcttcca     3240

gcctaggtac attgcatggg ctttgtgctc caggagttcc tacacagccc tcaacttcaa     3300

cacaggcaaa gtgcttactg atcctcatgt atcttacagg gtcccctcta cccacaatac     3360

ctcattgctg gaacttcaaa tcttcctgaa taaaagcttg cccgtggttt aatta          3415


<210> 8
<211> 247
<212> PRT
<213> Mus musculus

<400> 8
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His 
    210                 215                 220                 


Val Phe Ile Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val 
225                 230                 235                 240 


Ile Ile Gln Arg Lys Arg Ile 
                245         


<210> 9
<211> 1997
<212> DNA
<213> Homo sapiens

<400> 9
gctttctatt caagtgcctt ctgtgtgtgc acatgtgtaa tacatatctg ggatcaaagc       60

tatctatata aagtccttga ttctgtgtgg gttcaaacac atttcaaagc ttcaggatcc      120

tgaaaggttt tgctctactt cctgaagacc tgaacaccgc tcccataaag ccatggcttg      180

ccttggattt cagcggcaca aggctcagct gaacctggct accaggacct ggccctgcac      240

tctcctgttt tttcttctct tcatccctgt cttctgcaaa gcaatgcacg tggcccagcc      300

tgctgtggta ctggccagca gccgaggcat cgccagcttt gtgtgtgagt atgcatctcc      360

aggcaaagcc actgaggtcc gggtgacagt gcttcggcag gctgacagcc aggtgactga      420

agtctgtgcg gcaacctaca tgatggggaa tgagttgacc ttcctagatg attccatctg      480

cacgggcacc tccagtggaa atcaagtgaa cctcactatc caaggactga gggccatgga      540

cacgggactc tacatctgca aggtggagct catgtaccca ccgccatact acctgggcat      600

aggcaacgga acccagattt atgtaattga tccagaaccg tgcccagatt ctgacttcct      660

cctctggatc cttgcagcag ttagttcggg gttgtttttt tatagctttc tcctcacagc      720

tgtttctttg agcaaaatgc taaagaaaag aagccctctt acaacagggg tctatgtgaa      780

aatgccccca acagagccag aatgtgaaaa gcaatttcag ccttatttta ttcccatcaa      840

ttgagaaacc attatgaaga agagagtcca tatttcaatt tccaagagct gaggcaattc      900

taactttttt gctatccagc tatttttatt tgtttgtgca tttgggggga attcatctct      960

ctttaatata aagttggatg cggaacccaa attacgtgta ctacaattta aagcaaagga     1020

gtagaaagac agagctggga tgtttctgtc acatcagctc cactttcagt gaaagcatca     1080

cttgggatta atatggggat gcagcattat gatgtgggtc aaggaattaa gttagggaat     1140

ggcacagccc aaagaaggaa aaggcaggga gcgagggaga agactatatt gtacacacct     1200

tatatttacg tatgagacgt ttatagccga aatgatcttt tcaagttaaa ttttatgcct     1260

tttatttctt aaacaaatgt atgattacat caaggcttca aaaatactca catggctatg     1320

ttttagccag tgatgctaaa ggttgtattg catatataca tatatatata tatatatata     1380

tatatatata tatatatata tatatatata tatattttaa tttgatagta ttgtgcatag     1440

agccacgtat gtttttgtgt atttgttaat ggtttgaata taaacactat atggcagtgt     1500

ctttccacct tgggtcccag ggaagttttg tggaggagct caggacacta atacaccagg     1560

tagaacacaa ggtcatttgc taactagctt ggaaactgga tgaggtcata gcagtgcttg     1620

attgcgtgga attgtgctga gttggtgttg acatgtgctt tggggctttt acaccagttc     1680

ctttcaatgg tttgcaagga agccacagct ggtggtatct gagttgactt gacagaacac     1740

tgtcttgaag acaatggctt actccaggag acccacaggt atgaccttct aggaagctcc     1800

agttcgatgg gcccaattct tacaaacatg tggttaatgc catggacaga agaaggcagc     1860

aggtggcaga atggggtgca tgaaggtttc tgaaaattaa cactgcttgt gtttttaact     1920

caatattttc catgaaaatg caacaacatg tataatattt ttaattaaat aaaaatctgt     1980

ggtggtcgtt ttccgga                                                    1997


<210> 10
<211> 223
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 11
<211> 1933
<212> DNA
<213> Mus musculus

<400> 11
ctacacatat gtagcacgta ccttggatca aagctgtcta tataaagtcc ccgagtctgt       60

gtgggttcaa acacatctca aggcttctgg atcctgttgg gttttactct gctccctgag      120

gacctcagca catttgcccc ccagccatgg cttgtcttgg actccggagg tacaaagctc      180

aactgcagct gccttctagg acttggcctt ttgtagccct gctcactctt cttttcatcc      240

cagtcttctc tgaagccata caggtgaccc aaccttcagt ggtgttggct agcagccatg      300

gtgtcgccag ctttccatgt gaatattcac catcacacaa cactgatgag gtccgggtga      360

ctgtgctgcg gcagacaaat gaccaaatga ctgaggtctg tgccacgaca ttcacagaga      420

agaatacagt gggcttccta gattacccct tctgcagtgg tacctttaat gaaagcagag      480

tgaacctcac catccaagga ctgagagctg ttgacacggg actgtacctc tgcaaggtgg      540

aactcatgta cccaccgcca tactttgtgg gcatgggcaa cgggacgcag atttatgtca      600

ttgatccaga accatgcccg gattctgact tcctcctttg gatccttgtc gcagttagct      660

tggggttgtt tttttacagt ttcctggtca ctgctgtttc tttgagcaag atgctaaaga      720

aaagaagtcc tcttacaaca ggggtctatg tgaaaatgcc cccaacagag ccagaatgtg      780

aaaagcaatt tcagccttat tttattccca tcaactgaaa ggccgtttat gaagaagaag      840

gagcatactt cagtctctaa aagctgaggc aatttcaact ttccttttct ctccagctat      900

ttttacctgt ttgtatattt taaggagagt atgcctctct ttaatagaaa gctggatgca      960

aaattccaat taagcatact acaatttaaa gctaaggagc atgaacagag agctgggata     1020

tttctgttgt gtcagaacca ttttactaaa agcatcactt ggaagcagca taaggatata     1080

gcattatggt gtggggtcaa gggaacatta gggaatggca cagcccaaag aaaggaaggg     1140

ggtgaaggaa gagattatat tgtacacatc ttgtatttac ctgagagatg tttatgactt     1200

aaataatttt taaatttttc atgctgttat tttctttaac aatgtataat tacacgaagg     1260

tttaaacatt tattcacaga gctatgtgac atagccagtg gttccaaagg ttgtagtgtt     1320

ccaagatgta tttttaagta atattgtaca tgggtgtttc atgtgctgtt gtgtatttgc     1380

tggtggtttg aatataaaca ctatgtatca gtgtcgtccc acagtgggtc ctggggaggt     1440

ttggctgggg agcttaggac actaatccat caggttggac tcgaggtcct gcaccaactg     1500

gcttggaaac tagatgaggc tgtcacaggg ctcagttgca taaaccgatg gtgatggagt     1560

gtaaactggg tctttacact cattttattt tttgtttctg cttttgtttt cttcaatgat     1620

ttgcaaggaa accaaaagct ggcagtgttt gtatgaacct gacagaacac tgtcttcaag     1680

gaaatgcctc attcctgaga ccagtaggtt tgttttttta ggaagttcca atactaggac     1740

cccctacaag tactatggct cctcgaaaac acaaagttaa tgccacagga agcagcagat     1800

ggtaggatgg gatgcacaag agttcctgaa aactaacact gttagtgttt tttttttaac     1860

tcaatatttt ccatgaaaat gcaaccacat gtataatatt tttaattaaa taaaagtttc     1920

ttgtgattgt ttt                                                        1933


<210> 12
<211> 223
<212> PRT
<213> Mus musculus

<400> 12
Met Ala Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              


Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  


Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      


Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Val Ala Val Ser Leu Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Val Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 13
<211> 1634
<212> DNA
<213> Homo sapiens

<400> 13
agtctctcgt catggaatac gcctctgacg cttcactgga ccccgaagcc ccgtggcctc       60

ccgcgccccg cgctcgcgcc tgccgcgtac tgccttgggc cctggtcgcg gggctgctgc      120

tgctgctgct gctcgctgcc gcctgcgccg tcttcctcgc ctgcccctgg gccgtgtccg      180

gggctcgcgc ctcgcccggc tccgcggcca gcccgagact ccgcgagggt cccgagcttt      240

cgcccgacga tcccgccggc ctcttggacc tgcggcaggg catgtttgcg cagctggtgg      300

cccaaaatgt tctgctgatc gatgggcccc tgagctggta cagtgaccca ggcctggcag      360

gcgtgtccct gacggggggc ctgagctaca aagaggacac gaaggagctg gtggtggcca      420

aggctggagt ctactatgtc ttctttcaac tagagctgcg gcgcgtggtg gccggcgagg      480

gctcaggctc cgtttcactt gcgctgcacc tgcagccact gcgctctgct gctggggccg      540

ccgccctggc tttgaccgtg gacctgccac ccgcctcctc cgaggctcgg aactcggcct      600

tcggtttcca gggccgcttg ctgcacctga gtgccggcca gcgcctgggc gtccatcttc      660

acactgaggc cagggcacgc catgcctggc agcttaccca gggcgccaca gtcttgggac      720

tcttccgggt gacccccgaa atcccagccg gactcccttc accgaggtcg gaataacgtc      780

cagcctgggt gcagcccacc tggacagagt ccgaatccta ctccatcctt catggagacc      840

cctggtgctg ggtccctgct gctttctcta cctcaagggg cttggcaggg gtccctgctg      900

ctgacctccc cttgaggacc ctcctcaccc actccttccc caagttggac cttgatattt      960

attctgagcc tgagctcaga taatatatta tatatattat atatatatat atatttctat     1020

ttaaagagga tcctgagttt gtgaatggac ttttttagag gagttgtttt gggggggggg     1080

gggtcttcga cattgccgag gctggtcttg aactcctgga cttagacgat cctcctgcct     1140

cagcctccca agcaactggg attcatcctt tctattaatt cattgtactt atttgcttat     1200

ttgtgtgtat tgagcatctg taatgtgcca gcattgtgcc caggctaggg ggctatagaa     1260

acatctagaa atagactgaa agaaaatctg agttatggta atacgtgagg aatttaaaga     1320

ctcatcccca gcctccacct cctgtgtgat acttgggggc tagctttttt ctttctttct     1380

tttttttgag atggtcttgt tctgtcaacc aggctagaat gcagcggtgc aatcatgagt     1440

caatgcagcc tccagcctcg acctcccgag gctcaggtga tcctcccatc tcagcctctc     1500

gagtagctgg gaccacagtt gtgtgccacc acacttggct aactttttaa tttttttgcg     1560

gagacggtat tgctatgttg ccaaggttgt ttacatgcca gtacaattta taataaacac     1620

tcatttttcc tccc                                                       1634


<210> 14
<211> 254
<212> PRT
<213> Homo sapiens

<400> 14
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210> 15
<211> 1230
<212> DNA
<213> Mus musculus

<400> 15
ataaagcacg ggcactggcg ggagacgtgc actgaccgac cgtggtaatg gaccagcaca       60

cacttgatgt ggaggatacc gcggatgcca gacatccagc aggtacttcg tgcccctcgg      120

atgcggcgct cctcagagat accgggctcc tcgcggacgc tgcgctcctc tcagatactg      180

tgcgccccac aaatgccgcg ctccccacgg atgctgccta ccctgcggtt aatgttcggg      240

atcgcgaggc cgcgtggccg cctgcactga acttctgttc ccgccaccca aagctctatg      300

gcctagtcgc tttggttttg ctgcttctga tcgccgcctg tgttcctatc ttcacccgca      360

ccgagcctcg gccagcgctc acaatcacca cctcgcccaa cctgggtacc cgagagaata      420

atgcagacca ggtcacccct gtttcccaca ttggctgccc caacactaca caacagggct      480

ctcctgtgtt cgccaagcta ctggctaaaa accaagcatc gttgtgcaat acaactctga      540

actggcacag ccaagatgga gctgggagct catacctatc tcaaggtctg aggtacgaag      600

aagacaaaaa ggagttggtg gtagacagtc ccgggctcta ctacgtattt ttggaactga      660

agctcagtcc aacattcaca aacacaggcc acaaggtgca gggctgggtc tctcttgttt      720

tgcaagcaaa gcctcaggta gatgactttg acaacttggc cctgacagtg gaactgttcc      780

cttgctccat ggagaacaag ttagtggacc gttcctggag tcaactgttg ctcctgaagg      840

ctggccaccg cctcagtgtg ggtctgaggg cttatctgca tggagcccag gatgcataca      900

gagactggga gctgtcttat cccaacacca ccagctttgg actctttctt gtgaaacccg      960

acaacccatg ggaatgagaa ctatccttct tgtgactcct agttgctaag tcctcaagct     1020

gctatgtttt atggggtctg agcaggggtc ccttccatga ctttctcttg tctttaactg     1080

gacttggtat ttattctgag catagctcag acaagacttt atataattca ctagatagca     1140

ttagtaaact gctgggcagc tgctagataa aaaaaaattt ctaaatcaaa gtttatattt     1200

atattaatat ataaaaataa atgtgtttgt                                      1230


<210> 16
<211> 309
<212> PRT
<213> Mus musculus

<400> 16
Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210> 17
<211> 1702
<212> DNA
<213> Homo sapiens

<400> 17
ataccggccc ttcccctcgg ctttgcctgg acagctcctg cctcccgcag ggcccacctg       60

tgtcccccag cgccgctcca cccagcaggc ctgagcccct ctctgctgcc agacaccccc      120

tgctgcccac tctcctgctg ctcgggttct gaggcacagc ttgtcacacc gaggcggatt      180

ctctttctct ttctctttct cttctggccc acagccgcag caatggcgct gagttcctct      240

gctggagttc atcctgctag ctgggttccc gagctgccgg tctgagcctg aggcatggag      300

cctcctggag actgggggcc tcctccctgg agatccaccc ccaaaaccga cgtcttgagg      360

ctggtgctgt atctcacctt cctgggagcc ccctgctacg ccccagctct gccgtcctgc      420

aaggaggacg agtacccagt gggctccgag tgctgcccca agtgcagtcc aggttatcgt      480

gtgaaggagg cctgcgggga gctgacgggc acagtgtgtg aaccctgccc tccaggcacc      540

tacattgccc acctcaatgg cctaagcaag tgtctgcagt gccaaatgtg tgacccagcc      600

atgggcctgc gcgcgagccg gaactgctcc aggacagaga acgccgtgtg tggctgcagc      660

ccaggccact tctgcatcgt ccaggacggg gaccactgcg ccgcgtgccg cgcttacgcc      720

acctccagcc cgggccagag ggtgcagaag ggaggcaccg agagtcagga caccctgtgt      780

cagaactgcc ccccggggac cttctctccc aatgggaccc tggaggaatg tcagcaccag      840

accaagtgca gctggctggt gacgaaggcc ggagctggga ccagcagctc ccactgggta      900

tggtggtttc tctcagggag cctcgtcatc gtcattgttt gctccacagt tggcctaatc      960

atatgtgtga aaagaagaaa gccaaggggt gatgtagtca aggtgatcgt ctccgtccag     1020

cggaaaagac aggaggcaga aggtgaggcc acagtcattg aggccctgca ggcccctccg     1080

gacgtcacca cggtggccgt ggaggagaca ataccctcat tcacggggag gagcccaaac     1140

cactgaccca cagactctgc accccgacgc cagagatacc tggagcgacg gctgctgaaa     1200

gaggctgtcc acctggcgga accaccggag cccggaggct tgggggctcc gccctgggct     1260

ggcttccgtc tcctccagtg gagggagagg tggggcccct gctggggtag agctggggac     1320

gccacgtgcc attcccatgg gccagtgagg gcctggggcc tctgttctgc tgtggcctga     1380

gctccccaga gtcctgagga ggagcgccag ttgcccctcg ctcacagacc acacacccag     1440

ccctcctggg ccagcccaga gggcccttca gaccccagct gtctgcgcgt ctgactcttg     1500

tggcctcagc aggacaggcc ccgggcactg cctcacagcc aaggctggac tgggttggct     1560

gcagtgtggt gtttagtgga taccacatcg gaagtgattt tctaaattgg atttgaattc     1620

ggctcctgtt ttctatttgt catgaaacag tgtatttggg gagatgctgt gggaggatgt     1680

aaatatcttg tttctcctca aa                                              1702


<210> 18
<211> 283
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210> 19
<211> 893
<212> DNA
<213> Mus musculus

<400> 19
gctcttggcc tgaagtttct tgatcaagaa aatggaacct ctcccaggat gggggtcggc       60

accctggagc caggccccta cagacaacac cttcaggctg gtgccttgtg tcttcctttt      120

gaacttgctg cagcgcatct ctgcccagcc ctcatgcaga caggaggagt tccttgtggg      180

agacgagtgc tgccccatgt gcaacccagg ttaccatgtg aagcaggtct gcagtgagca      240

tacaggcaca gtgtgtgccc cctgtccccc acagacatat accgcccatg caaatggcct      300

gagcaagtgt ctgccctgcg gagtctgtga tccagacatg ggcctgctga cctggcagga      360

gtgctccagc tggaaggaca ctgtgtgcag atgcatccca ggctacttct gtgagaacca      420

ggatgggagc cactgttcca catgcttgca gcacaccacc tgccctccag ggcagagggt      480

agagaagaga gggactcacg accaggacac tgtatgtgct gactgcctaa cagggacctt      540

ctcacttgga gggactcagg aggaatgcct gccctggacc aactgcagtg catttcaaca      600

ggaagtaaga cgtgggacca acagcacaga caccacctgc tcctcccagg tcgtctacta      660

cgttgtgtcc atccttttgc cacttgtgat agtgggagct gggatagctg gattcctcat      720

ctgcacgcga agacacctgc acaccagctc agtggccaag gagctggagc ctttccagga      780

acaacaggag aacaccatca ggtttccagt caccgaggtt gggtttgctg agaccgagga      840

ggagacagcc tccaactgaa caaattctgg gtgacaagac accgaggaga cgt             893


<210> 20
<211> 275
<212> PRT
<213> Mus musculus

<400> 20
Met Glu Pro Leu Pro Gly Trp Gly Ser Ala Pro Trp Ser Gln Ala Pro 
1               5                   10                  15      


Thr Asp Asn Thr Phe Arg Leu Val Pro Cys Val Phe Leu Leu Asn Leu 
            20                  25                  30          


Leu Gln Arg Ile Ser Ala Gln Pro Ser Cys Arg Gln Glu Glu Phe Leu 
        35                  40                  45              


Val Gly Asp Glu Cys Cys Pro Met Cys Asn Pro Gly Tyr His Val Lys 
    50                  55                  60                  


Gln Val Cys Ser Glu His Thr Gly Thr Val Cys Ala Pro Cys Pro Pro 
65                  70                  75                  80  


Gln Thr Tyr Thr Ala His Ala Asn Gly Leu Ser Lys Cys Leu Pro Cys 
                85                  90                  95      


Gly Val Cys Asp Pro Asp Met Gly Leu Leu Thr Trp Gln Glu Cys Ser 
            100                 105                 110         


Ser Trp Lys Asp Thr Val Cys Arg Cys Ile Pro Gly Tyr Phe Cys Glu 
        115                 120                 125             


Asn Gln Asp Gly Ser His Cys Ser Thr Cys Leu Gln His Thr Thr Cys 
    130                 135                 140                 


Pro Pro Gly Gln Arg Val Glu Lys Arg Gly Thr His Asp Gln Asp Thr 
145                 150                 155                 160 


Val Cys Ala Asp Cys Leu Thr Gly Thr Phe Ser Leu Gly Gly Thr Gln 
                165                 170                 175     


Glu Glu Cys Leu Pro Trp Thr Asn Cys Ser Ala Phe Gln Gln Glu Val 
            180                 185                 190         


Arg Arg Gly Thr Asn Ser Thr Asp Thr Thr Cys Ser Ser Gln Val Val 
        195                 200                 205             


Tyr Tyr Val Val Ser Ile Leu Leu Pro Leu Val Ile Val Gly Ala Gly 
    210                 215                 220                 


Ile Ala Gly Phe Leu Ile Cys Thr Arg Arg His Leu His Thr Ser Ser 
225                 230                 235                 240 


Val Ala Lys Glu Leu Glu Pro Phe Gln Glu Gln Gln Glu Asn Thr Ile 
                245                 250                 255     


Arg Phe Pro Val Thr Glu Val Gly Phe Ala Glu Thr Glu Glu Glu Thr 
            260                 265                 270         


Ala Ser Asn 
        275 


<210> 21
<211> 1237
<212> DNA
<213> Homo sapiens

<400> 21
aatgcagtta caggatcctg ggaagcagag tgtctggatg gaacctgagc tgggtctctg       60

actcacttct gactttagtt ttttcaaggg ggaacatggc aaaggtgttc agtttcatcc      120

ttgttaccac cgctctgaca atgggcaggg aaatttcggc gctcgaggac tgtgcccagg      180

agcagatgcg gctcagagcc caggtgcgcc tgcttgagac ccgggtcaaa cagcaacagg      240

tcaagatcaa gcagcttttg caggagaatg aagtccagtt ccttgataaa ggagatgaga      300

atactgtcat tgatcttgga agcaagaggc agtatgcaga ttgttcagag attttcaatg      360

atgggtataa gctcagtgga ttttacaaaa tcaaacctct ccagagccca gcagaatttt      420

ctgtttattg tgacatgtcc gatggaggag gatggactgt aattcagaga cgatctgatg      480

gcagtgaaaa ctttaacaga ggatggaaag actatgaaaa tggctttgga aattttgtcc      540

aaaaacatgg tgaatattgg ctgggcaata aaaatcttca cttcttgacc actcaagaag      600

actacacttt aaaaatcgac cttgcagatt ttgaaaaaaa tagccgttat gcacaatata      660

agaatttcaa agttggagat gaaaagaatt tctacgagtt gaatattggg gaatattctg      720

gaacagctgg agattccctt gcggggaatt ttcatcctga ggtgcagtgg tgggctagtc      780

accaaagaat gaaattcagc acgtgggaca gagatcatga caactatgaa gggaactgcg      840

cagaagaaga tcagtctggc tggtggttta acaggtgtca ctctgcaaac ctgaatggtg      900

tatactacag cggcccctac acggctaaaa cagacaatgg gattgtctgg tacacctggc      960

atgggtggtg gtattctctg aaatctgtgg ttatgaaaat taggccaaat gattttattc     1020

caaatgtaat ttaattgctg ctgttgggct ttcgtttctg caattcagct ttgtttaaag     1080

tgatttgaaa aatactcatt ctgaacatat ccatgcgcaa tcatgataac tgttgtgagt     1140

agtgcttttc attcttctca cttgcctttg ttacttaatg tgctttcagt acagcagata     1200

tgcaatattc accaaataaa tgtagactgt gttaata                              1237


<210> 22
<211> 312
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210> 23
<211> 1120
<212> DNA
<213> Mus musculus

<400> 23
gttagaagtt cctgggaggc tctgtgtgga tggactgagc ctagctaagt cctgattcat       60

tttgacttga gttctctcag tgggaagaat gggaaagatt tacagcttcg tcctggtcgc      120

cattgctctg atgatgggaa gggaaggttg ggccctcgag agtgagaact gcttgcggga      180

gcaggtgagg ctcagggctc aggtgcacca gcttgagacc cgggtcaaac aacaacagac      240

catgattgca cagctcttgc atgagaagga agtccagttt ctggataaag gatcggagaa      300

cagtttcatt gaccttggag gcaagaagca gtatgcagat tgttcagaga tttacaatga      360

cggatttaag cagagtggat tttacaaaat caaacctctt cagagcctgg cagaattctc      420

tgtttattgt gacatgtctg atggaggggg atggactgta attcagagac gatctgatgg      480

cagtgagaac tttaacaggg gttggaatga ctatgaaaat ggctttggaa actttgtcca      540

aaacaatggc gaatactggc tgggtaacaa aaacattaac ttgctaacta ttcaaggaga      600

ctacacttta aaaatcgacc tgacagattt tgagaaaaac agcagcttcg cacaatacca      660

aagttttaaa gttggtgata aaaagtcttt ttatgaacta aatattggag aatattctgg      720

cacagctgga gattccctgt caggaacttt tcatcctgaa gtacagtggt gggctagtca      780

ccaaaggatg aagttcagca cgtgggacag agataacgac aattaccaag gaaactgtgc      840

tgaggaagag cagtctggct ggtggtttaa caggtgtcac tctgcaaacc tgaacggtgt      900

ttactaccgt ggttcctaca gggcagaaac ggataatggt gttgtgtggt acacctggca      960

tgggtggtgg tattccttga aatctgtggt tatgaaaatt aggccaagtg attttattcc     1020

aaatattatt tagttgccct cattgggatc tcctttctgt aattcatctt ggtttacttg     1080

aaaataaata tttgaaaaag atataattct gaataacaca                           1120


<210> 24
<211> 314
<212> PRT
<213> Mus musculus

<400> 24
Met Gly Lys Ile Tyr Ser Phe Val Leu Val Ala Ile Ala Leu Met Met 
1               5                   10                  15      


Gly Arg Glu Gly Trp Ala Leu Glu Ser Glu Asn Cys Leu Arg Glu Gln 
            20                  25                  30          


Val Arg Leu Arg Ala Gln Val His Gln Leu Glu Thr Arg Val Lys Gln 
        35                  40                  45              


Gln Gln Thr Met Ile Ala Gln Leu Leu His Glu Lys Glu Val Gln Phe 
    50                  55                  60                  


Leu Asp Lys Gly Ser Glu Asn Ser Phe Ile Asp Leu Gly Gly Lys Lys 
65                  70                  75                  80  


Gln Tyr Ala Asp Cys Ser Glu Ile Tyr Asn Asp Gly Phe Lys Gln Ser 
                85                  90                  95      


Gly Phe Tyr Lys Ile Lys Pro Leu Gln Ser Leu Ala Glu Phe Ser Val 
            100                 105                 110         


Tyr Cys Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg 
        115                 120                 125             


Ser Asp Gly Ser Glu Asn Phe Asn Arg Gly Trp Asn Asp Tyr Glu Asn 
    130                 135                 140                 


Gly Phe Gly Asn Phe Val Gln Asn Asn Gly Glu Tyr Trp Leu Gly Asn 
145                 150                 155                 160 


Lys Asn Ile Asn Leu Leu Thr Ile Gln Gly Asp Tyr Thr Leu Lys Ile 
                165                 170                 175     


Asp Leu Thr Asp Phe Glu Lys Asn Ser Ser Phe Ala Gln Tyr Gln Ser 
            180                 185                 190         


Phe Lys Val Gly Asp Lys Lys Ser Phe Tyr Glu Leu Asn Ile Gly Glu 
        195                 200                 205             


Tyr Ser Gly Thr Ala Gly Asp Ser Leu Ser Gly Thr Phe His Pro Glu 
    210                 215                 220                 


Val Gln Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp 
225                 230                 235                 240 


Arg Asp Asn Asp Asn Tyr Gln Gly Asn Cys Ala Glu Glu Glu Gln Ser 
                245                 250                 255     


Gly Trp Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr 
            260                 265                 270         


Tyr Arg Gly Ser Tyr Arg Ala Glu Thr Asp Asn Gly Val Val Trp Tyr 
        275                 280                 285             


Thr Trp His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile 
    290                 295                 300                 


Arg Pro Ser Asp Phe Ile Pro Asn Ile Ile 
305                 310                 


<210> 25
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 25
agagctccag gcgcacatcc gcagtcagcc acctcgcgcg cgcctccagg agcaaggatg       60

gagaggctgg tgatcaggat gcccttctct catctgtcta cctacagcct ggtttgggtc      120

atggcagcag tggtgctgtg cacagcacaa gtgcaagtgg tgacccagga tgaaagagag      180

cagctgtaca cacctgcttc cttaaaatgc tctctgcaaa atgcccagga agccctcatt      240

gtgacatggc agaaaaagaa agctgtaagc ccagaaaaca tggtcacctt cagcgagaac      300

catggggtgg tgatccagcc tgcctataag gacaagataa acattaccca gctgggactc      360

caaaactcaa ccatcacctt ctggaatatc accctggagg atgaagggtg ttacatgtgt      420

ctcttcaata cctttggttt tgggaagatc tcaggaacgg cctgcctcac cgtctatgta      480

cagcccatag tatcccttca ctacaaattc tctgaagacc acctaaatat cacttgctct      540

gccactgccc gcccagcccc catggtcttc tggaaggtcc ctcggtcagg gattgaaaat      600

agtacagtga ctctgtctca cccaaatggg accacgtctg ttaccagcat cctccatatc      660

aaagacccta agaatcaggt ggggaaggag gtgatctgcc aggtgctgca cctggggact      720

gtgaccgact ttaagcaaac cgtcaacaaa ggctattggt tttcagttcc gctattgcta      780

agcattgttt ccctggtaat tcttctcgtc ctaatctcaa tcttactgta ctggaaacgt      840

caccggaatc aggaccgaga gccctaaata agtcacacag caccctgaaa gtgattccct      900

ggtctacttg aatttgacac aagagaaaag caggaggaaa aggggccatt ctccaaagga      960

cctgaaagag caaaagaggt gggagcgaaa gccttaagga tcccacgact ttttactgcc     1020

atctgagcta ctcagtgttt gaatcccaag aggaagtcag tttacctctc aggtctgttg     1080

taggacttga ttttgtaaag caatgccatg ttatgtggtt gaaagggcac tggacttagt     1140

tagtatcagg agcactgagc tcacagactg acttgggctc ctactggtgg ggacctctgt     1200

tagtcacttt acctcatcca aagtataaag gaattggacc aaataattta ccacatagct     1260

ctaaaactta atttaaaatg taattccaga aaaaaaaagg gaataagcaa agggggaaga     1320

attgaaagag agagagaaga aagaatacag agagcttacc ttttgccttt ctgttgatgt     1380

tacatctctt cttcctatgt tcttaggtct atgagtctgt ttccccatca tttggtatct     1440

agtccagttc ctgcttactg ctttgctaat agctggcctt gctagaatcc ttggtttcac     1500

tgctgttctt catgtgcttc tatgagattt actccaacac aaataggact gaatttattg     1560

tgaagtaaca ttggcaatct taacttattc atttaactta tttttatagc tagataaata     1620

ttgttagtct tagacaatag ctcacatttt ttgagaagca tgccctccct gtccatttgt     1680

cttataacat gacccagccc tattttacgt cattctaaat tcagcctcat ataatgaaaa     1740

tacattatga aaacagatgt ttaggagatt tcctgtatag cagtcagcca attcatatgc     1800

tttgtctctg ctggcttctt tttccatgcg ttaacttttc ccaatagcag aggaggcaaa     1860

tatgagcata caatcccttt gttctaaaga tattgttcca gctagtggaa tgatgttgaa     1920

tctttaataa ccataattag ttgctttttc agtatcttct gctttgtctg tgtctatcca     1980

gtggcctagg aattaaagtg taagttgttt tcgctgttaa attggatatt tatatatata     2040

tatagcaaga ttttcatgtg ttatttaatt ctgtattgtt tcttatattt gtagtaaaat     2100

attgaacaat taaaagtgtt gactccaaa                                       2129


<210> 26
<211> 269
<212> PRT
<213> Homo sapiens

<400> 26
Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Glu Pro 
            260                 265                 


<210> 27
<211> 2363
<212> DNA
<213> Mus musculus

<400> 27
gggcgtggtt ggttggtcgt ctcttcctcc acactagagg agctgtagag tctgcctgtg       60

cagtggaggg ggctctctct acggcgaata gtagtgtccc tgctcacagg tgttgcggag      120

atatcctcca tcgtggaaga gctcagaccc cgagaagctg gtgtctagct gcggcccaga      180

gcaaggatgg gcagtctggt attcaggaga cctttctgcc atctctccac ctacagcctg      240

atttggggca tggcagcagt agcgctgagc acagctcaag tggaagtggt gacccaggat      300

gaaagaaagg cgctgcacac aactgcatcc ttacgatgtt ctctaaaaac atcccaggaa      360

cccttgattg tgacatggca gaaaaagaaa gccgtgagcc cagaaaacat ggtcacctac      420

agcaaaaccc atggggttgt aatccagcct gcctacaaag acaggataaa tgtcacagag      480

ctgggactct ggaactcaag catcaccttc tggaacacaa cattggaaga tgagggctgc      540

tacatgtgtc tcttcaacac gtttggttct cagaaggtct caggaacagc ttgccttacc      600

ctctatgtac agcccatagt acaccttcac tacaactatt ttgaagacca cctaaacatc      660

acttgctctg cgactgcccg tccagcccct gccatctcct ggaagggtac tgggacagga      720

attgagaata gtaccgagag tcacttccat tcaaatggga ctacatctgt caccagcatc      780

ctccgggtca aagaccccaa aactcaagtt gggaaggaag tgatctgcca ggttttatac      840

ctggggaatg tgattgacta caagcagagt ctggacaaag gattttggtt ttcagttcca      900

ctgttgctaa gcattgtttc tctggtaatt cttctgatct tgatctccat cttactatac      960

tggaaacgtc accgaaatca ggagcggggt gaatcatcac aggggatgca aagaatgaaa     1020

taagagctct aaagaaatta tacagaaccc tgaacgtgtt tccctggtct acttgaatct     1080

gatgtgaaag aaaagcagga gggaaaaggc cattctccat aggacctaag gagagcaaaa     1140

gaccagacac gagcctgtga gggatttgac tttttgctgt tgtcccaggt cctcggtgtt     1200

tgcattccaa gaggaagtcg agtgcctcgg gtctgttgta ggacttgatt tttttttttt     1260

ttgtagagca atgcagtgcc atgctgttag aaaggctcca gacttagaac caccagtgcc     1320

aagccagctc tcagaccgac tagggctccc atcggaggaa caaatcgtag tcaacttacc     1380

tcacagagct ctctggtcct tacacaaagt agaaaggagt gggaccagaa aattggccat     1440

gtctgaaatc tgatggaatt tttaggaaga aaactgaaga ataagcaaaa gaagaaagaa     1500

cacagaaggg tccaaagagc ttctgagagt accttttgcc tttctgttgg tgtcccagct     1560

ctggttttgt tcttaggtcc gccagtgtgt ttccctgttg tttgagtatc tagttgacta     1620

cctgctactg ttctgctgat ggttggcctt gctagaatcc ctgactcccc tgccgttctc     1680

tatgtgcttc tatgagggtt actatgatga aaatagagca gaagatagtg tgaagtaaca     1740

ttggcaactg taatgtgtcc atttaactta tttttatagc acttaggcaa tattgttagt     1800

cttagtgagt agttcacatc tttacaaaag catgctctcc ctatccattg ggcccacaat     1860

aacactctct ttgaggccat tctgaatcct gtctcgtgta atgataatat attatgaaaa     1920

cagatacttt aagaatttcc tgtacagcag tcagttgttt attctctctc tctctctctc     1980

tctctctctc cctcccccac cccagcttct ttttctgtga ctttgttttt cataaagaga     2040

aggcatctcc tgaatacaat cgctttgttc tgaagacatc gtgaactatt aattcttaac     2100

cctttgacaa aactagtgaa gttgttttct gtatcttttg cttcatctgt ctttatagag     2160

tgacctagga attcaagtgt aagttgtttc cattgttgaa ctggatattt atatacttgg     2220

tatgcttttc acgtgttatt taattctgta taatttccta tatttgtatt aaaatattga     2280

gcaattaaaa gtgtcaacta aatatttgat gtggcattcc cttgagaaat atagaaataa     2340

agaataaaaa aaaaaaaaaa aaa                                             2363


<210> 28
<211> 278
<212> PRT
<213> Mus musculus

<400> 28
Met Gly Ser Leu Val Phe Arg Arg Pro Phe Cys His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Ile Trp Gly Met Ala Ala Val Ala Leu Ser Thr Ala Gln Val 
            20                  25                  30          


Glu Val Val Thr Gln Asp Glu Arg Lys Ala Leu His Thr Thr Ala Ser 
        35                  40                  45              


Leu Arg Cys Ser Leu Lys Thr Ser Gln Glu Pro Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Tyr Ser Lys 
65                  70                  75                  80  


Thr His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Arg Ile Asn Val 
                85                  90                  95      


Thr Glu Leu Gly Leu Trp Asn Ser Ser Ile Thr Phe Trp Asn Thr Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Ser 
        115                 120                 125             


Gln Lys Val Ser Gly Thr Ala Cys Leu Thr Leu Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val His Leu His Tyr Asn Tyr Phe Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Ala Ile Ser Trp Lys Gly Thr Gly 
                165                 170                 175     


Thr Gly Ile Glu Asn Ser Thr Glu Ser His Phe His Ser Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu Arg Val Lys Asp Pro Lys Thr Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu Tyr Leu Gly Asn Val Ile Asp 
    210                 215                 220                 


Tyr Lys Gln Ser Leu Asp Lys Gly Phe Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Ile Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Glu Arg Gly Glu Ser Ser Gln 
            260                 265                 270         


Gly Met Gln Arg Met Lys 
        275             


<210> 29
<211> 1724
<212> DNA
<213> Homo sapiens

<400> 29
ctttgttaag tcgttccctc tacaaaggac ttcctagtgg gtgtgaaagg cagcggtggc       60

cacagaggcg gcggagagat ggccttcagc ggttcccagg ctccctacct gagtccagct      120

gtcccctttt ctgggactat tcaaggaggt ctccaggacg gacttcagat cactgtcaat      180

gggaccgttc tcagctccag tggaaccagg tttgctgtga actttcagac tggcttcagt      240

ggaaatgaca ttgccttcca cttcaaccct cggtttgaag atggagggta cgtggtgtgc      300

aacacgaggc agaacggaag ctgggggccc gaggagagga agacacacat gcctttccag      360

aaggggatgc cctttgacct ctgcttcctg gtgcagagct cagatttcaa ggtgatggtg      420

aacgggatcc tcttcgtgca gtacttccac cgcgtgccct tccaccgtgt ggacaccatc      480

tccgtcaatg gctctgtgca gctgtcctac atcagcttcc agaacccccg cacagtccct      540

gttcagcctg ccttctccac ggtgccgttc tcccagcctg tctgtttccc acccaggccc      600

agggggcgca gacaaaaacc tcccggcgtg tggcctgcca acccggctcc cattacccag      660

acagtcatcc acacagtgca gagcgcccct ggacagatgt tctctactcc cgccatccca      720

cctatgatgt acccccaccc cgcctatccg atgcctttca tcaccaccat tctgggaggg      780

ctgtacccat ccaagtccat cctcctgtca ggcactgtcc tgcccagtgc tcagaggttc      840

cacatcaacc tgtgctctgg gaaccacatc gccttccacc tgaacccccg ttttgatgag      900

aatgctgtgg tccgcaacac ccagatcgac aactcctggg ggtctgagga gcgaagtctg      960

ccccgaaaaa tgcccttcgt ccgtggccag agcttctcag tgtggatctt gtgtgaagct     1020

cactgcctca aggtggccgt ggatggtcag cacctgtttg aatactacca tcgcctgagg     1080

aacctgccca ccatcaacag actggaagtg gggggcgaca tccagctgac ccatgtgcag     1140

acataggcgg cttcctggcc ctggggccgg gggctggggt gtggggcagt ctgggtcctc     1200

tcatcatccc cacttcccag gcccagcctt tccaaccctg cctgggatct gggctttaat     1260

gcagaggcca tgtccttgtc tggtcctgct tctggctaca gccaccctgg aacggagaag     1320

gcagctgacg gggattgcct tcctcagccg cagcagcacc tggggctcca gctgctggaa     1380

tcctaccatc ccaggaggca ggcacagcca gggagagggg aggagtgggc agtgaagatg     1440

aagccccatg ctcagtcccc tcccatcccc cacgcagctc caccccagtc ccaagccacc     1500

agctgtctgc tcctggtggg aggtggcctc ctcagcccct cctctctgac ctttaacctc     1560

actctcacct tgcaccgtgc accaaccctt cacccctcct ggaaagcagg cctgatggct     1620

tcccactggc ctccaccacc tgaccagagt gttctcttca gaggactggc tcctttccca     1680

gtgtccttaa aataaagaaa tgaaaatgct tgttggcaca ttca                      1724


<210> 30
<211> 355
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210> 31
<211> 1586
<212> DNA
<213> Mus musculus

<400> 31
gccaaatagc tgtggtttct gtttcctagc tcagccctgc cctgcgcaga gttctgtcgt       60

ccaccatcga gtgaggaaga gagcattggt tcccctgaga tagaagagat ggctctcttc      120

agtgcccagt ctccatacat taacccgatc atccccttta ctggaccaat ccaaggaggg      180

ctgcaggagg gacttcaggt gaccctccag gggactacca agagttttgc acaaaggttt      240

gtggtgaact ttcagaacag cttcaatgga aatgacattg ccttccactt caacccccgg      300

tttgaggaag gagggtatgt ggtttgcaac acgaagcaga acggacagtg gggtcctgag      360

gagagaaaga tgcagatgcc cttccagaag gggatgccct ttgagctttg cttcctggtg      420

cagaggtcag agttcaaggt gatggtgaac aagaaattct ttgtgcagta ccaacaccgc      480

gtaccctacc acctcgtgga caccatcgct gtctccggct gcttgaagct gtcctttatc      540

accttccaga actctgcagc ccctgtccag catgtcttct ccacagtgca gttctctcag      600

ccagtccagt tcccacggac ccctaagggg cgcaaacaga aaactcagaa ctttcgtcct      660

gcccaccagg cacccatggc tcaaactacc atccatatgg ttcacagcac ccctggacag      720

atgttctcta ctcctggaat ccctcctgtg gtgtacccca ccccagccta taccatacct      780

ttctacaccc ccattccaaa tgggctttac ccgtccaagt ccatcatgat atcaggcaat      840

gtcttgccag atgctacgag gttccatatc aaccttcgct gtggaggtga cattgctttc      900

cacctgaacc cccgtttcaa tgagaatgct gttgtccgaa acactcagat caacaactcc      960

tgggggcagg aagagcgaag tctgcttggg aggatgccct tcagtcgagg ccagagcttc     1020

tcggtgtgga tcatatgtga aggtcactgc ttcaaggtag ctgtgaatgg tcaacacatg     1080

tgtgaatatt accaccgcct gaagaacttg caggatatca acactctaga agtggcgggt     1140

gatatccagc tgacccacgt gcagacatag gcaaggtctc tggcctaggg ataagggctg     1200

gagcactctg cctgtgtctt atctttcccc tgtctcagcc ctggcaccat cagaagagat     1260

catcacttat aggaattcca ggaaggtgaa attcccaatt gactccctcc acaaaggggg     1320

ttttctaggc tgtgtggcac atggctgtca gcccatagtc tgagccattg cccccaagct     1380

agctatatac tgagggaagt gaccctcctg ggtttgctca gatctctgat cgttcccccc     1440

tctgtggccc ttttctttca cccctccagg agagccaccc tgatatcatc ccactggcct     1500

ccaactgacc cacaatgtcc acagtaactt tcccccattc tcacccagta tccataaaat     1560

aaagaaataa tattgcttgt ctacac                                          1586


<210> 32
<211> 353
<212> PRT
<213> Mus musculus

<400> 32
Met Ala Leu Phe Ser Ala Gln Ser Pro Tyr Ile Asn Pro Ile Ile Pro 
1               5                   10                  15      


Phe Thr Gly Pro Ile Gln Gly Gly Leu Gln Glu Gly Leu Gln Val Thr 
            20                  25                  30          


Leu Gln Gly Thr Thr Lys Ser Phe Ala Gln Arg Phe Val Val Asn Phe 
        35                  40                  45              


Gln Asn Ser Phe Asn Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg 
    50                  55                  60                  


Phe Glu Glu Gly Gly Tyr Val Val Cys Asn Thr Lys Gln Asn Gly Gln 
65                  70                  75                  80  


Trp Gly Pro Glu Glu Arg Lys Met Gln Met Pro Phe Gln Lys Gly Met 
                85                  90                  95      


Pro Phe Glu Leu Cys Phe Leu Val Gln Arg Ser Glu Phe Lys Val Met 
            100                 105                 110         


Val Asn Lys Lys Phe Phe Val Gln Tyr Gln His Arg Val Pro Tyr His 
        115                 120                 125             


Leu Val Asp Thr Ile Ala Val Ser Gly Cys Leu Lys Leu Ser Phe Ile 
    130                 135                 140                 


Thr Phe Gln Asn Ser Ala Ala Pro Val Gln His Val Phe Ser Thr Val 
145                 150                 155                 160 


Gln Phe Ser Gln Pro Val Gln Phe Pro Arg Thr Pro Lys Gly Arg Lys 
                165                 170                 175     


Gln Lys Thr Gln Asn Phe Arg Pro Ala His Gln Ala Pro Met Ala Gln 
            180                 185                 190         


Thr Thr Ile His Met Val His Ser Thr Pro Gly Gln Met Phe Ser Thr 
        195                 200                 205             


Pro Gly Ile Pro Pro Val Val Tyr Pro Thr Pro Ala Tyr Thr Ile Pro 
    210                 215                 220                 


Phe Tyr Thr Pro Ile Pro Asn Gly Leu Tyr Pro Ser Lys Ser Ile Met 
225                 230                 235                 240 


Ile Ser Gly Asn Val Leu Pro Asp Ala Thr Arg Phe His Ile Asn Leu 
                245                 250                 255     


Arg Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asn Glu 
            260                 265                 270         


Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Gln Glu 
        275                 280                 285             


Glu Arg Ser Leu Leu Gly Arg Met Pro Phe Ser Arg Gly Gln Ser Phe 
    290                 295                 300                 


Ser Val Trp Ile Ile Cys Glu Gly His Cys Phe Lys Val Ala Val Asn 
305                 310                 315                 320 


Gly Gln His Met Cys Glu Tyr Tyr His Arg Leu Lys Asn Leu Gln Asp 
                325                 330                 335     


Ile Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val Gln 
            340                 345                 350         


Thr 
    


<210> 33
<211> 5792
<212> DNA
<213> Homo sapiens

<400> 33
agtcacttgt ctggagcttg aagaagtggg tattcccctt cccaccccag gcactggagg       60

agcggccccc cggggattcc aggacctgag ctccgggagc tggactcgca gcgaccgcgg      120

cagagcgagc gggcgccggg aagcgaggag acgcccgcgg gaggcccagc tgctcggagc      180

aactggcatg gcccgagcca tggccgccgc gtggccgctg ctgctggtgg cgctactggt      240

gctgtcctgg ccacccccag gaaccgggga cgtcgtcgtg caggcgccca cccaggtgcc      300

cggcttcttg ggcgactccg tgacgctgcc ctgctaccta caggtgccca acatggaggt      360

gacgcatgtg tcacagctga cttgggcgcg gcatggtgaa tctggcagca tggccgtctt      420

ccaccaaacg cagggcccca gctattcgga gtccaaacgg ctggaattcg tggcagccag      480

actgggcgcg gagctgcgga atgcctcgct gaggatgttc gggttgcgcg tagaggatga      540

aggcaactac acctgcctgt tcgtcacgtt cccgcagggc agcaggagcg tggatatctg      600

gctccgagtg cttgccaagc cccagaacac agctgaggtt cagaaggtcc agctcactgg      660

agagccagtg cccatggccc gctgcgtctc cacagggggt cgcccgccag cccaaatcac      720

ctggcactca gacctgggcg ggatgcccaa tacgagccag gtgccagggt tcctgtctgg      780

cacagtcact gtcaccagcc tctggatatt ggtgccctca agccaggtgg acggcaagaa      840

tgtgacctgc aaggtggagc acgagagctt tgagaagcct cagctgctga ctgtgaacct      900

caccgtgtac taccccccag aggtatccat ctctggctat gataacaact ggtaccttgg      960

ccagaatgag gccaccctga cctgcgatgc tcgcagcaac ccagagccca caggctataa     1020

ttggagcacg accatgggtc ccctgccacc ctttgctgtg gcccagggcg cccagctcct     1080

gatccgtcct gtggacaaac caatcaacac aactttaatc tgcaacgtca ccaatgccct     1140

aggagctcgc caggcagaac tgaccgtcca ggtcaaagag ggacctccca gtgagcactc     1200

aggcatgtcc cgtaacgcca tcatcttcct ggttctggga atcctggttt ttctgatcct     1260

gctggggatc gggatttatt tctattggtc caaatgttcc cgtgaggtcc tttggcactg     1320

tcatctgtgt ccctcgagta cagagcatgc cagcgcctca gctaatgggc atgtctccta     1380

ttcagctgtg agcagagaga acagctcttc ccaggatcca cagacagagg gcacaaggtg     1440

acagcgtcgg gactgagagg ggagagagac tggagctggc aaggacgtgg gcctccagag     1500

ttggacccga ccccaatgga tgaagacccc ctccaaagag accagcctcc ctccctgtgc     1560

cagacctcaa aacgacgggg gcaggtgcaa gttcataggt ctccaagacc accctccttt     1620

catttgctag aaggactcac tagactcagg aaagctgtta ggctcacagt tacagtttat     1680

tacagtaaaa ggacagagat taagatcagc aaagggagga ggtgcacagc acacgttcca     1740

cgacagatga ggcgacggct tccatctgcc ctctcccagt ggagccatat aggcagcacc     1800

tgattctcac agcaacatgt gacaacatgc aagaagtact gccaatactg ccaaccagag     1860

cagctcactc gagatctttg tgtccagagt tttttgtttg tcttgagaca gggtctggct     1920

ctgttggcag actagagtac agtggtgaga tcacagttca ttgcagcctt gacttctcaa     1980

cgccaagtca tcctcccacc tcagcctcct gagtagctat gactacaggt atgtgccacc     2040

acgtctggct aatcttttta ttatttgtaa agtcgaggtt tccctgtgtt gcccaggctg     2100

gtcttgaact cttggctcca agtgatactt ctgccttggc ctcccaaagt gctgaattaa     2160

gcagctcacc atccacacgg ctgacctcat acatcaagcc aataccgtgt ggcccaagac     2220

ccccaccata aatcacatca ttagcatgaa ccacccagag tggcccaaga ctccaagatc     2280

agctaccagg caggatattc caagggctta gagatgaatg cccaggagct gaggataaag     2340

ggcccgatct ttctttgggc aaggttaagc ctttactgca tagcagacca cacagaaggg     2400

tgtgggccac cagagaattt tggtaaaaat ttggcctctg gccttgagct tctaaatctc     2460

tgtatccgtc agatctctgt ggttacaaga aacagccact gaccctggtc accagaggct     2520

gcaattcagg ccgcaagcag ctgcctgggg ggtgtccaag gagcagagaa aactactaga     2580

tgtgaacttg aagaaggttg tcagctgcag ccactttctg ccagcatctg cagccacttt     2640

ctgccagcat ctgcagccag caagctggga ctggcaggaa ataacccaca aaagaagcaa     2700

atgcaatttc caacacaagg gggaagggat gcagggggag gcagcgctgc agttgctcag     2760

gacacgctcc tataggacca agatggatgc gacccaagac ccaggaggcc cagctgctca     2820

gtgcaactga caagttaaaa aggtctatga tcttgagggc agacagcaga attcctctta     2880

taaagaaaac tgtttgggaa aatacgttga gggagagaag accttgggcc aagatgctaa     2940

atgggaatgc aaagcttgag ctgctctgca agagaaaata agcaggacag aggatttgct     3000

ctggacagag atggaagagc cgggaacaga gaagtgtggg gaagagatag gaaccagcag     3060

gatggcaggg gcaaagggct caagggtgag gaggccagtg ggaccccaca gagttgggga     3120

gataaaggaa cattggttgc tttggtggca cgtaagctcc ttgtctgtct ccagcaccca     3180

gaatctcatt aaagcttatt tattgtacct ccagcggctg tgtgcaatgg ggtcttttgt     3240

ggaaatcaag gagcagacag gtttcatgtg tactgtcacc acgtgggatg gaaccagagg     3300

catggaagca agacgctaaa tgaagagggc cataagggct gggattccca ggcaccttag     3360

gaacagcttg tctttttttt tttcctctcc aaaaaaaatg tttaagggac ggtgtctcct     3420

gtcacccagg ctggagtgca atggcacgat catagctcat tgcagcctct aactccgggg     3480

ctcaagcaat cctcccacct cagcctacca agtagctgtg accacagctg cccctcacca     3540

tgctaagcta atttttttaa ttagatagta cataaacgtc ccaaaattag aagataaaaa     3600

gacatgaggg atccattcta atttgtgttt ggagtgtaat ggtccagctc cattcttctg     3660

cacatggata tccagtttta cacaacactg tgaatgtaat gaatgccact gaatcataca     3720

ctcaaaaata gctaaaatgg caaattgtct gttatctctt tttaaccacc atttttgaaa     3780

attaattata ccaaaaaacc attgaatagt gcactttatt tatttattta tttgtttatt     3840

tatttattta ttttagaaat aagagtctca ctttgttgcc caggctggag tgcagtggcg     3900

tgatcatggc tcattgcagc ctcgacctgc tgggctcggg ctatccttcc atctcagcct     3960

cccgagtagc tgggactata ggtgggcgcc accccacctg gctaaatctc tttttaactt     4020

ttgtagagat aggcatctcg ctatgttgcc taggctgggc tggaactcct gggctcaagt     4080

gctcctcctg ccttggcctc ccaaagcgct aggattacag atgtgagcca ccgcgcccac     4140

cctgaacctt actttttttg ctcagtttct ggtaattcag agaatgcctc ctgagttgtt     4200

ctacacccac ctcatattcc atgggagggc tgtacagggc ttttttaacg aggcctctaa     4260

ggacaggcat ttgtatcctt tccagccttt cactattaca atgttgtagt gaataacttt     4320

acacactgtc atttatttta cttttttttt tttttatttt agagaaagga atcttgccat     4380

cttgcccagg ctggtctcaa attcctgggc ccaaacaatc ctcccgcctt ggcctcctaa     4440

agtactggga tttataggca taagccaccg tgcctggcca atgcacactg tcatttagct     4500

catgttaaca cctgagtgta ggacacactc ctggaggtgg aattgctggg ccaaagagta     4560

tgtttcttgt cattgtgata gatattgaca aatgaaccct cacagaagtt gtgctgagtt     4620

ctgttcccac cagcgacgta ggcgatgacc tttttctgga gggagggggc atccttggag     4680

tccacagagc caggaatgga gagtgggccc agaattttgg tataggtgtt gtataaactt     4740

atagtaaggt taagaaaacc gcaactatcc ttatcagaga cttggcgggg ggcagggtat     4800

gatggagatc ataaggaggc taaaacactc cacaccctcc ctctgcattg ctcctgcacg     4860

ggagtcggga atcttttcag gttgatacga tctcaccttg aggagctgtg aggtcccaga     4920

agcctctggg ttgcagattg cttggggtga aaatgtctgt gctactgaaa tctaactttt     4980

tacaaaaaat tacgggctgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg     5040

ctgcagcggg tggatcactt gaggtaagga gttcaagacc agaccatagt gaaaccgtgt     5100

ctctacaaaa aaaattagcc aggtgtggtg gtgcatgctt gtaatcccag ctactcagaa     5160

ggctgaggtg ggagaatccc ttgaacccgg gaagtggagg ctggagtaaa ccatgatcga     5220

gttactgcac tccagcctgg gtgacaagag tgagactctg tctccaaaaa aaaaaaaaaa     5280

aaaaaaaaaa ctggattgcc tggctctact ccgggcacag catgcaggcc cagttctgct     5340

gctctgctgt ttgttctgct ttcctccaca tattggcatc accctctggt gccaagatgg     5400

ctgctgcatt ccaggcatca catccagact cagacccaga gaagctgccc atccctacct     5460

gggtgagcct ttgtaggaac gagaaaccgc atccagcagc agaaacctca cccagcagcg     5520

tcttttccgg tctcattcac cagcgccgcc caccgctcaa ccaatccctg gccaaaagaa     5580

tgggaccgcc tggaaggctg gaccaaacag gacctgccct ctggggctgg ggagaggccc     5640

agatgaaggc tgcaggacag gatggactcc tagacctctg ttaccagcag tgactacctc     5700

tgtctgggtg gttggaacat gtttgaattt tattctaagt actgtctaca agttctgcaa     5760

taaaccttga ctcttctttt aataatgcaa aa                                   5792


<210> 34
<211> 417
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210> 35
<211> 2902
<212> DNA
<213> Mus musculus

<400> 35
aggcggcacc cgcttagctg agattccagc acttgacttc agggtttcgg agagataagg       60

cgcttggccg ttactaactg gactacaaag agctggatcg gaccggaacc acatggctca      120

actcgcccga gccacccgct ccccgctgtc atggctgctg ctgctgttct gctatgcact      180

ccggaaagcg ggtggggata tacgtgtgct ggtgccctac aattcgacag gcgtcttggg      240

agggtcgacc accttgcact gtagtctgac ttctaatgag aatgtgacta tcactcaaat      300

aacctggatg aagaaggatt caggtggatc ccacgctctt gtggctgtct tccaccccaa      360

gaaggggccc aacatcaaag agccagagag ggtgaaattc ttggctgccc aacaggatct      420

gaggaacgca tctctggcca tctcgaactt aagtgtagaa gacgaaggca tctatgaatg      480

tcagattgcc acattcccca gaggcagtag aagcaccaat gcctggctga aggtgcaagc      540

ccgacctaag aacactgcag aggccctgga gccctctccc accttgatac tgcaggatgt      600

ggctaaatgc atctctgcca atggtcaccc tcctggacga atctcttggc cctcgaatgt      660

gaatggaagt caccgtgaaa tgaaggaacc agggtcccag ccgggcacca ccacagttac      720

cagctacctc tccatggtac cttctcgcca ggcagacggc aagaacatca cctgcacggt      780

ggagcatgaa agcttacagg agctggacca gctgctggtg accctttccc aaccctatcc      840

acctgaaaac gtgtccatct ctggctatga cggcaactgg tatgttggcc tcactaactt      900

gaccctgacc tgtgaagctc acagcaaacc agcgcctgac atggctggat ataactggag      960

cacgaacacg ggtgactttc ccaactctgt taagcgccag ggcaatatgc ttctaatctc     1020

caccgtagag gatggtctca ataacacggt cattgtgtgc gaagtcacca atgccctagg     1080

gtctgggcag ggccaagtgc acatcattgt taaagagaaa cctgagaata tgcagcaaaa     1140

tacaagatta cacctaggct acatctttct tatcgtcttt gtcctcgctg tagtcatcat     1200

catcgcagca ctatacacta tacgaagatg caggcatggt cgtgctctgc agtccaatcc     1260

ctcagagagg gagaacgtcc agtattcatc tgtgaacggc gactgtagac tgaacatgga     1320

gccaaacagc acaaggtgac ggtgctgggt agacagaact aaggaacttg aaggcatagc     1380

aactggaacc ctactctcat aaatgaagaa gcctccagag agactggctg ctcagtgtga     1440

tgagcatagc aagtttgggg ggtctcccag gatgctgccg aattccacgt tgtcaaaagg     1500

acccatggag gccagtgtgt tggctcactc ttgacatctc agcaagctgg gggggggggg     1560

gggagcataa agcaaggttg agtctagctt gggctataga gcaaagccct gtccatacac     1620

aaacaagcta aggggctttg agacggtcag aaactgaagt cttgctttgg gtaaggtaaa     1680

tcctctaccg catgtatgtg ctagacttga aagacttcca cacagacctc tttataagtt     1740

gactccattg gggctatccc ctcctctctg gacaaggtct ctgtatgtag ccaaggctag     1800

gctcaaactc acagagatat gtctgcttct acctccccag tgctagagtt gaaagtattt     1860

gtgccactgc acttttctag gtcttctttt aatgaagtaa agtatatatt tataaaaagc     1920

tatttagtta tatatatata tatttttgag actatttcat agagcccaag ctaacctcaa     1980

acttactatg tagccaagag tgatggtaaa ctaatttatt ttaatttatt tgtcttcaat     2040

tttaaccatc acccaacccc tgctcccttc catatcttct ttcaatccat ttcattgtct     2100

ttttcttccc agacactatt ctgacttacg tctccattac aaacatttta ttgaactaca     2160

taaaaatgtg tgaaccacaa aaaaaaaatg tatttgtcaa aattgtagtt gtctttctga     2220

ggctgacctg agttctctga taccattctc tccagttgta tccagtttcc tgtaaacaat     2280

gtgactttgt ttttctcagt agctaaaaca tcccaattat gtgagtgtac actttcttta     2340

ctcattcctc tgtgggccac cagctgggtt ggttccatat ctgagctatt gtgcatggaa     2400

ttgtctctgt ggtgggttta gtaaactccc aggaatgcct gtacatgttt gtagaggcca     2460

gaagaaggca caaaatcttg agccaggctt acatgcactt gtgagtagcc ccacataggt     2520

gctaagaacc cagttcaggt cctctgctgt gggatggtgg gctgtgcaca gaaagcctgg     2580

tcccggtcta gcaaaggtct ggaactccgg agccggtggg ctgtgattta caccagcatg     2640

ggatggaagg agttggacct cgcctcctgg gcacctggct cctgtcacat agctacagcc     2700

tcccacagcc cccctatagg gaggtatgca gcatcaatca catagtagct gcactaagcc     2760

ctcccacatg caaataaggt ttccccaaac tctcagtcca agccaatgaa aagtacctgc     2820

tgtcaaaccc taaatcatcc ccaaaactct gtaagtccta tcagggaata aaatgtgtgt     2880

gaaaactaaa aaaaaaaaaa aa                                              2902


<210> 36
<211> 408
<212> PRT
<213> Mus musculus

<400> 36
Met Ala Gln Leu Ala Arg Ala Thr Arg Ser Pro Leu Ser Trp Leu Leu 
1               5                   10                  15      


Leu Leu Phe Cys Tyr Ala Leu Arg Lys Ala Gly Gly Asp Ile Arg Val 
            20                  25                  30          


Leu Val Pro Tyr Asn Ser Thr Gly Val Leu Gly Gly Ser Thr Thr Leu 
        35                  40                  45              


His Cys Ser Leu Thr Ser Asn Glu Asn Val Thr Ile Thr Gln Ile Thr 
    50                  55                  60                  


Trp Met Lys Lys Asp Ser Gly Gly Ser His Ala Leu Val Ala Val Phe 
65                  70                  75                  80  


His Pro Lys Lys Gly Pro Asn Ile Lys Glu Pro Glu Arg Val Lys Phe 
                85                  90                  95      


Leu Ala Ala Gln Gln Asp Leu Arg Asn Ala Ser Leu Ala Ile Ser Asn 
            100                 105                 110         


Leu Ser Val Glu Asp Glu Gly Ile Tyr Glu Cys Gln Ile Ala Thr Phe 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Thr Asn Ala Trp Leu Lys Val Gln Ala Arg 
    130                 135                 140                 


Pro Lys Asn Thr Ala Glu Ala Leu Glu Pro Ser Pro Thr Leu Ile Leu 
145                 150                 155                 160 


Gln Asp Val Ala Lys Cys Ile Ser Ala Asn Gly His Pro Pro Gly Arg 
                165                 170                 175     


Ile Ser Trp Pro Ser Asn Val Asn Gly Ser His Arg Glu Met Lys Glu 
            180                 185                 190         


Pro Gly Ser Gln Pro Gly Thr Thr Thr Val Thr Ser Tyr Leu Ser Met 
        195                 200                 205             


Val Pro Ser Arg Gln Ala Asp Gly Lys Asn Ile Thr Cys Thr Val Glu 
    210                 215                 220                 


His Glu Ser Leu Gln Glu Leu Asp Gln Leu Leu Val Thr Leu Ser Gln 
225                 230                 235                 240 


Pro Tyr Pro Pro Glu Asn Val Ser Ile Ser Gly Tyr Asp Gly Asn Trp 
                245                 250                 255     


Tyr Val Gly Leu Thr Asn Leu Thr Leu Thr Cys Glu Ala His Ser Lys 
            260                 265                 270         


Pro Ala Pro Asp Met Ala Gly Tyr Asn Trp Ser Thr Asn Thr Gly Asp 
        275                 280                 285             


Phe Pro Asn Ser Val Lys Arg Gln Gly Asn Met Leu Leu Ile Ser Thr 
    290                 295                 300                 


Val Glu Asp Gly Leu Asn Asn Thr Val Ile Val Cys Glu Val Thr Asn 
305                 310                 315                 320 


Ala Leu Gly Ser Gly Gln Gly Gln Val His Ile Ile Val Lys Glu Lys 
                325                 330                 335     


Pro Glu Asn Met Gln Gln Asn Thr Arg Leu His Leu Gly Tyr Ile Phe 
            340                 345                 350         


Leu Ile Val Phe Val Leu Ala Val Val Ile Ile Ile Ala Ala Leu Tyr 
        355                 360                 365             


Thr Ile Arg Arg Cys Arg His Gly Arg Ala Leu Gln Ser Asn Pro Ser 
    370                 375                 380                 


Glu Arg Glu Asn Val Gln Tyr Ser Ser Val Asn Gly Asp Cys Arg Leu 
385                 390                 395                 400 


Asn Met Glu Pro Asn Ser Thr Arg 
                405             


<210> 37
<211> 1987
<212> DNA
<213> Homo sapiens

<400> 37
gtgacgtcag cgggttcgaa ccgccggagc tgagcgagag gccgggggtg ccgagccggg       60

cggggagagc tgggccggga gagcagaaca gggaggctag agcgcagcgg gaaccggccc      120

ggagccggag ccggagcccc acaggcacct actaaaccgc ccagccgatc ggcccccaca      180

gagtggcccg cgggcctccg gccgggccca gtcccctccc gggccctcca tggcccgggc      240

cgctgccctc ctgccgtcga gatcgccgcc gacgccgctg ctgtggccgc tgctgctgct      300

gctgctcctg gaaaccggag cccaggatgt gcgagttcaa gtgctacccg aggtgcgagg      360

ccagctcggg ggcaccgtgg agctgccgtg ccacctgctg ccacctgttc ctggactgta      420

catctccctg gtgacctggc agcgcccaga tgcacctgcg aaccaccaga atgtggccgc      480

cttccaccct aagatgggtc ccagcttccc cagcccgaag cctggcagcg agcggctgtc      540

cttcgtctct gccaagcaga gcactgggca agacacagag gcagagctcc aggacgccac      600

gctggccctc cacgggctca cggtggagga cgagggcaac tacacttgcg agtttgccac      660

cttccccaag gggtccgtcc gagggatgac ctggctcaga gtcatagcca agcccaagaa      720

ccaagctgag gcccagaagg tcacgttcag ccaggaccct acgacagtgg ccctctgcat      780

ctccaaagag ggccgcccac ctgcccggat ctcctggctc tcatccctgg actgggaagc      840

caaagagact caggtgtcag ggaccctggc cggaactgtc actgtcacca gccgcttcac      900

cttggtgccc tcgggccgag cagatggtgt cacggtcacc tgcaaagtgg agcatgagag      960

cttcgaggaa ccagccctga tacctgtgac cctctctgta cgctaccctc ctgaagtgtc     1020

catctccggc tatgatgaca actggtacct cggccgtact gatgccaccc tgagctgtga     1080

cgtccgcagc aacccagagc ccacgggcta tgactggagc acgacctcag gcaccttccc     1140

gacctccgca gtggcccagg gctcccagct ggtcatccac gcagtggaca gtctgttcaa     1200

taccaccttc gtctgcacag tcaccaatgc cgtgggcatg ggccgcgctg agcaggtcat     1260

ctttgtccga gaaaccccca gggcctcgcc ccgagatgtg ggcccgctgg tgtggggggc     1320

cgtggggggg acactgctgg tgctgctgct tctggctggg gggtccttgg ccttcatcct     1380

gctgagggtg aggaggagga ggaagagccc tggaggagca ggaggaggag ccagtggcga     1440

cgggggattc tacgatccga aagctcaggt gttgggaaat ggggaccccg tcttctggac     1500

accagtagtc cctggtccca tggaaccaga tggcaaggat gaggaggagg aggaggagga     1560

agagaaggca gagaaaggcc tcatgttgcc tccaccccca gcactcgagg atgacatgga     1620

gtcccagctg gacggctccc tcatctcacg gcgggcagtt tatgtgtgac ctggacacag     1680

acagagacag agccaggccc ggccctcccg cccccgacct gaccacgccg gcctagggtt     1740

ccagactggt tggacttgtt cgtctggacg acactggagt ggaacactgc ctcccacttt     1800

cttgggactt ggagggaggt ggaacagcac actggacttc tcccgtctct agggctgcat     1860

ggggagcccg gggagctgag tagtggggat ccagagagga cccccgcccc cagagacttg     1920

gttttggctc cagccttccc ctggccccgt gacactcagg agttaataaa tgccttggag     1980

gaaaaca                                                               1987


<210> 38
<211> 479
<212> PRT
<213> Homo sapiens

<400> 38
Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Arg Ala 
            340                 345                 350         


Ser Pro Arg Asp Val Gly Pro Leu Val Trp Gly Ala Val Gly Gly Thr 
        355                 360                 365             


Leu Leu Val Leu Leu Leu Leu Ala Gly Gly Ser Leu Ala Phe Ile Leu 
    370                 375                 380                 


Leu Arg Val Arg Arg Arg Arg Lys Ser Pro Gly Gly Ala Gly Gly Gly 
385                 390                 395                 400 


Ala Ser Gly Asp Gly Gly Phe Tyr Asp Pro Lys Ala Gln Val Leu Gly 
                405                 410                 415     


Asn Gly Asp Pro Val Phe Trp Thr Pro Val Val Pro Gly Pro Met Glu 
            420                 425                 430         


Pro Asp Gly Lys Asp Glu Glu Glu Glu Glu Glu Glu Glu Lys Ala Glu 
        435                 440                 445             


Lys Gly Leu Met Leu Pro Pro Pro Pro Ala Leu Glu Asp Asp Met Glu 
    450                 455                 460                 


Ser Gln Leu Asp Gly Ser Leu Ile Ser Arg Arg Ala Val Tyr Val 
465                 470                 475                 


<210> 39
<211> 2009
<212> DNA
<213> Mus musculus

<400> 39
gagccctagg atcggcttgg cgaagagggg cggggcctgt gacgtcatga gtccggcccg       60

ctggagctaa gcgaggggcc ggggggcgcg gatcctgaga gccaggcgag ggaaagctgg      120

gccgaacgaa ctgatccggg gagccgtgag cggcggaagc cggcctggag ccggacactt      180

cagacccctg actgccctcc cagccgatcg gtacacgaag agtggtccct aggcaccccc      240

tgcccgggcc cagtccctcc ccgggccccc catggcccgg gccgcagtcc tcccgccgtc      300

cagattgtca ccgacgctgc cgttgttgcc gctgctactg ctcctgcttc aggaaacagg      360

agcccaagat gtgcgggtac gagtgcttcc cgaggtccgg ggccgcttgg gaggcaccgt      420

ggagttaccg tgccacctgc tcccacccac gacggagcgc gtctctcagg tgacctggca      480

gcgcctggat ggcacagttg tggctgcttt ccacccatcc ttcggagtgg atttccccaa      540

ctctcagttc agcaaggacc gtctgtcctt tgtcagagcg agaccagaaa caaacgcaga      600

cctgcgggat gccacactgg ccttccgggg actgagggta gaggacgagg gcaattacac      660

ctgcgagttt gccacgtttc ccaacggtac ccgcaggggg gtgacctggc tcagagtcat      720

agcccagcct gagaaccacg ctgaagccca ggaggtcaca attggccccc agtcggtggc      780

tgtagcccgc tgtgtctcca ctgggggccg cccccctgcc cgaatcacct ggatctcatc      840

tctgggtgga gaggccaaag atactcagga gccagggata caggctggca ccgtcactat      900

catcagccga tactccttgg tgcccgtggg ccgagcggat ggcgtcaagg tcacgtgtag      960

agtggaacac gagagcttcg aagagccgat cctgctgcca gtgaccctct ctgtgcgcta     1020

ccctccagaa gtatccatct ccggctatga tgacaactgg taccttggcc gcagtgaggc     1080

catactgacc tgtgatgtac gaagcaaccc agagcccaca gactatgact ggagcacgac     1140

ctcgggcgtc ttcccagcct ctgcagtggc ccagggctct cagctgcttg tccactctgt     1200

ggatcgaatg gtcaacacta ccttcatctg tacagccacc aacgctgtgg ggacaggccg     1260

tgctgagcag gtcatcctgg tgcgagacac cccccaggcc tcccgagatg tgggtccgct     1320

ggtgtggggg gccgtggggg gaacattgct ggtgctactc ctggctgggg ggttcctggc     1380

cttgatcctg ctgaggggga ggaggaggcg gaagagccct ggaggaggag gaaatgatgg     1440

cgacagagga tcctacgatc caaagactca ggtgtttggg aacgggggtc ctgtcttctg     1500

gaggtcagca tcccctgagc ccatgaggcc agatggcagg gaggaagatg aggaggagga     1560

ggaagaaatg aaggcagagg aaggtctcat gctacctcca cacgagtcac ctaaggacga     1620

catggagtcc catctggatg gctccctcat ctctcggcgg gcagtttacg tgtgacccta     1680

cgatatagac actggacaca tggaaacacc aagttccacc ctcactgcca accacaccaa     1740

tgccagccag caacgatggc tagggaccgg ttggactggt tcttctgggg cacactggag     1800

ttggaagggc accgcccctg ctttcaggat agaggacaag tggaaccaca cagactccta     1860

tctttagggc ctcatggagt aggggacccc aggagcgcca tggtgcacac tcaggactcc     1920

tcagagcttg ctttcggccc cagcctagcc ctggccccga aacactcagg agctaataaa     1980

tgccttgtcg gaaaaaaaaa aaaaaaaaa                                       2009


<210> 40
<211> 467
<212> PRT
<213> Mus musculus

<400> 40
Met Ala Arg Ala Ala Val Leu Pro Pro Ser Arg Leu Ser Pro Thr Leu 
1               5                   10                  15      


Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gln Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Arg Val Leu Pro Glu Val Arg Gly Arg Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Thr Thr Glu Arg Val 
    50                  55                  60                  


Ser Gln Val Thr Trp Gln Arg Leu Asp Gly Thr Val Val Ala Ala Phe 
65                  70                  75                  80  


His Pro Ser Phe Gly Val Asp Phe Pro Asn Ser Gln Phe Ser Lys Asp 
                85                  90                  95      


Arg Leu Ser Phe Val Arg Ala Arg Pro Glu Thr Asn Ala Asp Leu Arg 
            100                 105                 110         


Asp Ala Thr Leu Ala Phe Arg Gly Leu Arg Val Glu Asp Glu Gly Asn 
        115                 120                 125             


Tyr Thr Cys Glu Phe Ala Thr Phe Pro Asn Gly Thr Arg Arg Gly Val 
    130                 135                 140                 


Thr Trp Leu Arg Val Ile Ala Gln Pro Glu Asn His Ala Glu Ala Gln 
145                 150                 155                 160 


Glu Val Thr Ile Gly Pro Gln Ser Val Ala Val Ala Arg Cys Val Ser 
                165                 170                 175     


Thr Gly Gly Arg Pro Pro Ala Arg Ile Thr Trp Ile Ser Ser Leu Gly 
            180                 185                 190         


Gly Glu Ala Lys Asp Thr Gln Glu Pro Gly Ile Gln Ala Gly Thr Val 
        195                 200                 205             


Thr Ile Ile Ser Arg Tyr Ser Leu Val Pro Val Gly Arg Ala Asp Gly 
    210                 215                 220                 


Val Lys Val Thr Cys Arg Val Glu His Glu Ser Phe Glu Glu Pro Ile 
225                 230                 235                 240 


Leu Leu Pro Val Thr Leu Ser Val Arg Tyr Pro Pro Glu Val Ser Ile 
                245                 250                 255     


Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly Arg Ser Glu Ala Ile Leu 
            260                 265                 270         


Thr Cys Asp Val Arg Ser Asn Pro Glu Pro Thr Asp Tyr Asp Trp Ser 
        275                 280                 285             


Thr Thr Ser Gly Val Phe Pro Ala Ser Ala Val Ala Gln Gly Ser Gln 
    290                 295                 300                 


Leu Leu Val His Ser Val Asp Arg Met Val Asn Thr Thr Phe Ile Cys 
305                 310                 315                 320 


Thr Ala Thr Asn Ala Val Gly Thr Gly Arg Ala Glu Gln Val Ile Leu 
                325                 330                 335     


Val Arg Asp Thr Pro Gln Ala Ser Arg Asp Val Gly Pro Leu Val Trp 
            340                 345                 350         


Gly Ala Val Gly Gly Thr Leu Leu Val Leu Leu Leu Ala Gly Gly Phe 
        355                 360                 365             


Leu Ala Leu Ile Leu Leu Arg Gly Arg Arg Arg Arg Lys Ser Pro Gly 
    370                 375                 380                 


Gly Gly Gly Asn Asp Gly Asp Arg Gly Ser Tyr Asp Pro Lys Thr Gln 
385                 390                 395                 400 


Val Phe Gly Asn Gly Gly Pro Val Phe Trp Arg Ser Ala Ser Pro Glu 
                405                 410                 415     


Pro Met Arg Pro Asp Gly Arg Glu Glu Asp Glu Glu Glu Glu Glu Glu 
            420                 425                 430         


Met Lys Ala Glu Glu Gly Leu Met Leu Pro Pro His Glu Ser Pro Lys 
        435                 440                 445             


Asp Asp Met Glu Ser His Leu Asp Gly Ser Leu Ile Ser Arg Arg Ala 
    450                 455                 460                 


Val Tyr Val 
465         


<210> 41
<211> 2690
<212> DNA
<213> Homo sapiens

<400> 41
gtgacgtcag cgggttcgaa ccgccggagc tgagcgagag gccgggggtg ccgagccggg       60

cggggagagc tgggccggga gagcagaaca gggaggctag agcgcagcgg gaaccggccc      120

ggagccggag ccggagcccc acaggcacct actaaaccgc ccagccgatc ggcccccaca      180

gagtggcccg cgggcctccg gccgggccca gtcccctccc gggccctcca tggcccgggc      240

cgctgccctc ctgccgtcga gatcgccgcc gacgccgctg ctgtggccgc tgctgctgct      300

gctgctcctg gaaaccggag cccaggatgt gcgagttcaa gtgctacccg aggtgcgagg      360

ccagctcggg ggcaccgtgg agctgccgtg ccacctgctg ccacctgttc ctggactgta      420

catctccctg gtgacctggc agcgcccaga tgcacctgcg aaccaccaga atgtggccgc      480

cttccaccct aagatgggtc ccagcttccc cagcccgaag cctggcagcg agcggctgtc      540

cttcgtctct gccaagcaga gcactgggca agacacagag gcagagctcc aggacgccac      600

gctggccctc cacgggctca cggtggagga cgagggcaac tacacttgcg agtttgccac      660

cttccccaag gggtccgtcc gagggatgac ctggctcaga gtcatagcca agcccaagaa      720

ccaagctgag gcccagaagg tcacgttcag ccaggaccct acgacagtgg ccctctgcat      780

ctccaaagag ggccgcccac ctgcccggat ctcctggctc tcatccctgg actgggaagc      840

caaagagact caggtgtcag ggaccctggc cggaactgtc actgtcacca gccgcttcac      900

cttggtgccc tcgggccgag cagatggtgt cacggtcacc tgcaaagtgg agcatgagag      960

cttcgaggaa ccagccctga tacctgtgac cctctctgta cgctaccctc ctgaagtgtc     1020

catctccggc tatgatgaca actggtacct cggccgtact gatgccaccc tgagctgtga     1080

cgtccgcagc aacccagagc ccacgggcta tgactggagc acgacctcag gcaccttccc     1140

gacctccgca gtggcccagg gctcccagct ggtcatccac gcagtggaca gtctgttcaa     1200

taccaccttc gtctgcacag tcaccaatgc cgtgggcatg ggccgcgctg agcaggtcat     1260

ctttgtccga gagaccccca acacagcagg cgcaggggcc acaggcggca tcatcggggg     1320

catcatcgcc gccatcattg ctactgctgt ggctgccacg ggcatcctta tctgccggca     1380

gcagcggaag gagcagacgc tgcagggggc agaggaggac gaagacctgg agggacctcc     1440

ctcctacaag ccaccgaccc caaaagcgaa gctggaggca caggagatgc cctcccagct     1500

cttcactctg ggggcctcgg agcacagccc actcaagacc ccctactttg atgctggcgc     1560

ctcatgcact gagcaggaaa tgcctcgata ccatgagctg cccaccttgg aagaacggtc     1620

aggacccttg caccctggag ccacaagcct ggggtccccc atcccggtgc ctccagggcc     1680

acctgctgtg gaagacgttt ccctggatct agaggatgag gagggggagg aggaggaaga     1740

gtatctggac aagatcaacc ccatctatga tgctctgtcc tatagcagcc cctctgattc     1800

ctaccagggc aaaggctttg tcatgtcccg ggccatgtat gtgtgagctg ccatgcgcct     1860

ggcgtctcac atctcacctg ttgatccctt agctttcttg ccaaggatct agtgccccct     1920

gacctctggc caggccactg tcagttaaca catatgcatt ccatttgtga tgtctacctt     1980

ggtggctcca ctatgacccc taacccatga gcccagagaa attcaccgtg ataatggaat     2040

cctggcaacc ttatctcatg aggcaggagg tggggaaggt gcttctgcac aacctctgat     2100

cccaaggact cctctcccag actgtgacct tagaccatac ctctcacccc ccaatgcctc     2160

gactccccca aaatcacaaa gaagacccta gacctataat ttgtcttcag gtagtaaatt     2220

cccaataggt ctgctggagt gggcgctgag ggctccctgc tgctcagacc tgagccctcc     2280

aggcagcagg gtcccactta ccccctcccc accctgttcc ccaaaggtgg gaaagagggg     2340

attccccagc ccaaggcagg gttttcccag caccctcctg taagcagaag tctcagggtc     2400

cagacccttc cctgagcccc cacccccacc ccaattcctg cctaccaagc aagcagcccc     2460

agcctagggt cagacagggt gagcctcata cagactgtgc cttgatggcc ccagccttgg     2520

gagaagaatt tactgttaac ctggaagact actgaatcat tttacccttg cccagtggaa     2580

taggacctaa acatccccct tccggggaaa gtgggtcatc tgaattgggg gtagcaattg     2640

atactgtttt gtaaactaca tttcctacaa aatatgaatt tatactttga                2690


<210> 42
<211> 538
<212> PRT
<213> Homo sapiens

<400> 42
Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210> 43
<211> 2735
<212> DNA
<213> Mus musculus

<400> 43
gagccctagg atcggcttgg cgaagagggg cggggcctgt gacgtcatga gtccggcccg       60

ctggagctaa gcgaggggcc ggggggcgcg gatcctgaga gccaggcgag ggaaagctgg      120

gccgaacgaa ctgatccggg gagccgtgag cggcggaagc cggcctggag ccggacactt      180

cagacccctg actgccctcc cagccgatcg gtacacgaag agtggtccct aggcaccccc      240

tgcccgggcc cagtccctcc ccgggccccc catggcccgg gccgcagtcc tcccgccgtc      300

cagattgtca ccgacgctgc cgttgttgcc gctgctactg ctcctgcttc aggaaacagg      360

agcccaagat gtgcgggtac gagtgcttcc cgaggtccgg ggccgcttgg gaggcaccgt      420

ggagttaccg tgccacctgc tcccacccac gacggagcgc gtctctcagg tgacctggca      480

gcgcctggat ggcacagttg tggctgcttt ccacccatcc ttcggagtgg atttccccaa      540

ctctcagttc agcaaggacc gtctgtcctt tgtcagagcg agaccagaaa caaacgcaga      600

cctgcgggat gccacactgg ccttccgggg actgagggta gaggacgagg gcaattacac      660

ctgcgagttt gccacgtttc ccaacggtac ccgcaggggg gtgacctggc tcagagtcat      720

agcccagcct gagaaccacg ctgaagccca ggaggtcaca attggccccc agtcggtggc      780

tgtagcccgc tgtgtctcca ctgggggccg cccccctgcc cgaatcacct ggatctcatc      840

tctgggtgga gaggccaaag atactcagga gccagggata caggctggca ccgtcactat      900

catcagccga tactccttgg tgcccgtggg ccgagcggat ggcgtcaagg tcacgtgtag      960

agtggaacac gagagcttcg aagagccgat cctgctgcca gtgaccctct ctgtgcgcta     1020

ccctccagaa gtatccatct ccggctatga tgacaactgg taccttggcc gcagtgaggc     1080

catactgacc tgtgatgtac gaagcaaccc agagcccaca gactatgact ggagcacgac     1140

ctcgggcgtc ttcccagcct ctgcagtggc ccagggctct cagctgcttg tccactctgt     1200

ggatcgaatg gtcaacacta ccttcatctg tacagccacc aacgctgtgg ggacaggccg     1260

tgctgagcag gtcatcctgg tgcgagagtc acccagcaca gcaggagcag gggccactgg     1320

tggcatcatt ggaggtatta tcgctgccat catcgccacc gcagtggctg gcacaggcat     1380

cctcatctgc cgacaacagc ggaaggagca gaggcttcaa gctgcggatg aggaagaaga     1440

actggaagga cctccctcct ataaaccacc caccccgaag gccaagctgg aggaaccaga     1500

gatgccctct caactcttca ccttgggggc ctcagagcac agcccagtga agacgccata     1560

ctttgatgct ggtgtctctt gtgctgatca ggagatgcct cggtatcacg agctgcccac     1620

tctggaagag cggtcagggc ccctgctgtt gggggctaca ggcctgggac cttctcttct     1680

ggtgcctcca ggacccaatg ttgtggaggg ggtttccctg agtctcgaag atgaggagga     1740

agatgatgag gaggaagact tcctggataa aatcaaccct atttatgatg ccctgtccta     1800

ccccagcccc tctgactcct accagagcaa agactttttt gtgtcacggg ccatgtatgt     1860

gtgagggagg cacaggggct ctgacgtctc acctttcacc cttgacccat gagctttcca     1920

ccagtaatct aggacactct gacttccagg cagaccaggg acaactatca cccattgcaa     1980

tccacctgtg acttcttagt gactccacca tgacgtccaa tctatgatgt ctgaggcagg     2040

caaacctgca caactggaaa cctggagatt tttatctccc ttggcaggga gctcaccata     2100

tccttctgca ccacctgtga cccccccccc ccccccaagg actcctaaga ctacgaccct     2160

ttgaccatgc cactcagtat ctcaagaacc cttaaagtcc caaaggaatc ggaccttgca     2220

cttgtcctca ggcaatagag tccaacagat atgcaagaac gggatcaggg gctccctgtt     2280

gctcagacct gagccctcca ggcagcagaa gctcacctga tccctcccca ccctgctccc     2340

caaaggtgaa aaggagagga ttccccaatg taaggtagga cctccccatc tccacctact     2400

cctgcaggca ggaatctcag gtttctcaca ccctctcctc agcacccagg ttcctgtctc     2460

cagagcatga attccaggtc caatgctaga ggggagaacc taatgcaagt gtgccttgcc     2520

accccaagtt tgggagactc tgctcttatc ctgaggacta ctgaattctt ttaaccccta     2580

cccagtgaga tgagaactac atatccctct ttaggggatg gtgtgtgtat gtgtgtgtga     2640

tggagaatct gggcatctgg gttgggaatt ttattttgta agcatttcct acataatatg     2700

agtttctact ttgataaagt cttgtgtttt ctgtg                                2735


<210> 44
<211> 530
<212> PRT
<213> Mus musculus

<400> 44
Met Ala Arg Ala Ala Val Leu Pro Pro Ser Arg Leu Ser Pro Thr Leu 
1               5                   10                  15      


Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gln Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Arg Val Leu Pro Glu Val Arg Gly Arg Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Thr Thr Glu Arg Val 
    50                  55                  60                  


Ser Gln Val Thr Trp Gln Arg Leu Asp Gly Thr Val Val Ala Ala Phe 
65                  70                  75                  80  


His Pro Ser Phe Gly Val Asp Phe Pro Asn Ser Gln Phe Ser Lys Asp 
                85                  90                  95      


Arg Leu Ser Phe Val Arg Ala Arg Pro Glu Thr Asn Ala Asp Leu Arg 
            100                 105                 110         


Asp Ala Thr Leu Ala Phe Arg Gly Leu Arg Val Glu Asp Glu Gly Asn 
        115                 120                 125             


Tyr Thr Cys Glu Phe Ala Thr Phe Pro Asn Gly Thr Arg Arg Gly Val 
    130                 135                 140                 


Thr Trp Leu Arg Val Ile Ala Gln Pro Glu Asn His Ala Glu Ala Gln 
145                 150                 155                 160 


Glu Val Thr Ile Gly Pro Gln Ser Val Ala Val Ala Arg Cys Val Ser 
                165                 170                 175     


Thr Gly Gly Arg Pro Pro Ala Arg Ile Thr Trp Ile Ser Ser Leu Gly 
            180                 185                 190         


Gly Glu Ala Lys Asp Thr Gln Glu Pro Gly Ile Gln Ala Gly Thr Val 
        195                 200                 205             


Thr Ile Ile Ser Arg Tyr Ser Leu Val Pro Val Gly Arg Ala Asp Gly 
    210                 215                 220                 


Val Lys Val Thr Cys Arg Val Glu His Glu Ser Phe Glu Glu Pro Ile 
225                 230                 235                 240 


Leu Leu Pro Val Thr Leu Ser Val Arg Tyr Pro Pro Glu Val Ser Ile 
                245                 250                 255     


Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly Arg Ser Glu Ala Ile Leu 
            260                 265                 270         


Thr Cys Asp Val Arg Ser Asn Pro Glu Pro Thr Asp Tyr Asp Trp Ser 
        275                 280                 285             


Thr Thr Ser Gly Val Phe Pro Ala Ser Ala Val Ala Gln Gly Ser Gln 
    290                 295                 300                 


Leu Leu Val His Ser Val Asp Arg Met Val Asn Thr Thr Phe Ile Cys 
305                 310                 315                 320 


Thr Ala Thr Asn Ala Val Gly Thr Gly Arg Ala Glu Gln Val Ile Leu 
                325                 330                 335     


Val Arg Glu Ser Pro Ser Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile 
            340                 345                 350         


Ile Gly Gly Ile Ile Ala Ala Ile Ile Ala Thr Ala Val Ala Gly Thr 
        355                 360                 365             


Gly Ile Leu Ile Cys Arg Gln Gln Arg Lys Glu Gln Arg Leu Gln Ala 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Leu Glu Gly Pro Pro Ser Tyr Lys Pro Pro 
385                 390                 395                 400 


Thr Pro Lys Ala Lys Leu Glu Glu Pro Glu Met Pro Ser Gln Leu Phe 
                405                 410                 415     


Thr Leu Gly Ala Ser Glu His Ser Pro Val Lys Thr Pro Tyr Phe Asp 
            420                 425                 430         


Ala Gly Val Ser Cys Ala Asp Gln Glu Met Pro Arg Tyr His Glu Leu 
        435                 440                 445             


Pro Thr Leu Glu Glu Arg Ser Gly Pro Leu Leu Leu Gly Ala Thr Gly 
    450                 455                 460                 


Leu Gly Pro Ser Leu Leu Val Pro Pro Gly Pro Asn Val Val Glu Gly 
465                 470                 475                 480 


Val Ser Leu Ser Leu Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp 
                485                 490                 495     


Phe Leu Asp Lys Ile Asn Pro Ile Tyr Asp Ala Leu Ser Tyr Pro Ser 
            500                 505                 510         


Pro Ser Asp Ser Tyr Gln Ser Lys Asp Phe Phe Val Ser Arg Ala Met 
        515                 520                 525             


Tyr Val 
    530 


<210> 45
<211> 1630
<212> DNA
<213> Homo sapiens

<400> 45
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatca                                                            1630


<210> 46
<211> 178
<212> PRT
<213> Homo sapiens

<400> 46
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 47
<211> 1306
<212> DNA
<213> Mus musculus

<400> 47
acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag       60

ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat      120

cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag      180

ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttcaaacaaa      240

ggaccagctg gacaacatac tgctaaccga ctccttaatg caggacttta agggttactt      300

gggttgccaa gccttatcgg aaatgatcca gttttacctg gtagaagtga tgccccaggc      360

agagaagcat ggcccagaaa tcaaggagca tttgaattcc ctgggtgaga agctgaagac      420

cctcaggatg cggctgaggc gctgtcatcg atttctcccc tgtgaaaata agagcaaggc      480

agtggagcag gtgaagagtg attttaataa gctccaagac caaggtgtct acaaggccat      540

gaatgaattt gacatcttca tcaactgcat agaagcatac atgatgatca aaatgaaaag      600

ctaaaacacc tgcagtgtgt attgagtctg ctggactcca ggacctagac agagctctct      660

aaatctgatc cagggatctt agctaacgga aacaactcct tggaaaacct cgtttgtacc      720

tctctccgaa atatttatta cctctgatac ctcagttccc attctattta ttcactgagc      780

ttctctgtga actatttaga aagaagccca atattataat tttacagtat ttattatttt      840

taacctgtgt ttaagctgtt tccattgggg acactttata gtatttaaag ggagattata      900

ttatatgatg ggaggggttc ttccttggga agcaattgaa gcttctattc taaggctggc      960

cacacttgag agctgcaggg ccctttgcta tggtgtcctt tcaattgctc tcatccctga     1020

gttcagagct cctaagagag ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg     1080

agatcctttg atgatcattc ctgcagcagc tcagagggtt cccctactgt catcccccag     1140

ccgcttcatc cctgaaaact gtggccagtt tgttatttat aaccacctaa aattagttct     1200

aatagaactc atttttaact agaagtaatg caattcctct gggaatggtg tattgtttgt     1260

ctgcctttgt agcagactct aattttgaat aaatggatct tattcg                    1306


<210> 48
<211> 178
<212> PRT
<213> Mus musculus

<400> 48
Met Pro Gly Ser Ala Leu Leu Cys Cys Leu Leu Leu Leu Thr Gly Met 
1               5                   10                  15      


Arg Ile Ser Arg Gly Gln Tyr Ser Arg Glu Asp Asn Asn Cys Thr His 
            20                  25                  30          


Phe Pro Val Gly Gln Ser His Met Leu Leu Glu Leu Arg Thr Ala Phe 
        35                  40                  45              


Ser Gln Val Lys Thr Phe Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile 
    50                  55                  60                  


Leu Leu Thr Asp Ser Leu Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Val Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Lys His Gly Pro Glu Ile Lys Glu His Leu Asn Ser Leu 
            100                 105                 110         


Gly Glu Lys Leu Lys Thr Leu Arg Met Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Ser 
    130                 135                 140                 


Asp Phe Asn Lys Leu Gln Asp Gln Gly Val Tyr Lys Ala Met Asn Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Cys Ile Glu Ala Tyr Met Met Ile Lys Met 
                165                 170                 175     


Lys Ser 
        


<210> 49
<211> 1439
<212> DNA
<213> Homo sapiens

<400> 49
agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc       60

actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact      120

caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc      180

ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag      240

gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga      300

aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc      360

attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc      420

cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt      480

ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac      540

gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg      600

agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata      660

tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca      720

gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg      780

acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa      840

ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc      900

cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt      960

ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa     1020

agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa     1080

cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt     1140

cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa     1200

ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata     1260

aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata     1320

ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg     1380

tcattttcat aaatattgtt gcaataaata tccttgaaca cacaaaaaaa aaaaaaaaa      1439


<210> 50
<211> 277
<212> PRT
<213> Homo sapiens

<400> 50
Met Ile Ile Leu Ile Tyr Leu Phe Leu Leu Leu Trp Glu Asp Thr Gln 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asp Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Arg Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Gln 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Glu Asp Asn Gln Ile 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu Asp Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Asp Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Ala Met Asp Pro Val Ser Lys Ser Ser Gln Gly 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Ser Thr Gly Asn Lys Asn Phe Leu Ala Gly 
            260                 265                 270         


Arg Phe Ser His Leu 
        275         


<210> 51
<211> 1601
<212> DNA
<213> Mus musculus

<400> 51
ccgctgctct gagaatttcg tgtgggcagc cccgacattg taaccggctc tgcaaccgaa       60

gagatggtcg tcctcctttg cttatgcgtc ttgctgtggg aagaggctca cggatgggga      120

ttcaagaacg ggatctttca taactccata tggcttgaac aagcagcggg cgtataccac      180

agagaagctc gggctggcag atacaagctc acctacgccg aagccaaggc cgtatgtgaa      240

tttgaaggtg gtcgtctcgc aacctacaag cagctagagg cagccagaaa aattggattc      300

catgtctgtg ctgctggatg gatggccaag ggtagagtcg gataccccat tgtgaaacct      360

gggcccaact gtggatttgg gaaaacgggt atcatcgatt atggaatccg gctcaacagg      420

agtgagcgat gggatgccta ttgctacaac ccacatgcaa aggagtgtgg tggtgtcttc      480

acagatccga agcgaatttt taaatccccg ggcttcccaa atgagtacga tgacaaccag      540

gtctgctact ggcacattcg gctcaagtac ggtcagcgaa ttcacctgag ctttttggac      600

tttgaccttg aacatgatcc aggctgcttg gctgactatg tagaaatcta tgacagttat      660

gatgacgtcc acggctttgt aggaagatac tgtggtgatg aacttccaga agacatcatt      720

agcacaggaa atgtcatgac cttgaagttt ctgagtgatg catccgtcac ggctggaggc      780

ttccagatta aatacgtcac agtggatcct gcatctaaat ccagtcaagc caaaaataca      840

agtactactg gaaataagaa gttcttacct ggaaggttta gccatctata aaaaattttt      900

tttaaaaatg ttcaaaacat ccagtacaat atttatattt gtttttgttg ttgttgttgg      960

tttttttttt tttattttgt tttgttttgt ttttttgaga cggggtttct ctgtatagcc     1020

ttggctgtcc tggaactcac tttgaagacc aggctggcct cgaactcaga aatccacctg     1080

cctccgccta ccaagtgctg ggattaaagg cgtccaccac caccgcccgg cttcaatatt     1140

tatatttgta gctcttggac ctcgtttgtt ctcttttgta tttttattat taacatgtat     1200

ttattatttt tccaaatgtg aaagccatat gtaattatgt ggaaaattga caaataaata     1260

cagagaactt caaatgagtt ttttttttaa atctcataat tgtactacac agaaataact     1320

aatgttaaag tttttaaatg tttgtctttc attcattttt ctacttgtag tatatgtaca     1380

tatgtaactc tatgatttgc gtttgaattt tggcattctg ccttttgtaa cctgatattt     1440

ttaaccttga cattgtatag ctcaagcact tcccaagatc tctgagtttt ctacaaaatg     1500

ggactttgta aatatgattg ttccctgctt tatttaagct gaatttatat taggatttaa     1560

ggttgttttc ataaatattg ctgtaataaa tacttttgga t                         1601


<210> 52
<211> 275
<212> PRT
<213> Mus musculus

<400> 52
Met Val Val Leu Leu Cys Leu Cys Val Leu Leu Trp Glu Glu Ala His 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asn Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Gln Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ala Gly Arg Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly Arg 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Arg 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Asp Asp Asn Gln Val 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu His Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Glu Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Thr Val Asp Pro Ala Ser Lys Ser Ser Gln Ala 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Gly Asn Lys Lys Phe Leu Pro Gly Arg Phe 
            260                 265                 270         


Ser His Leu 
        275 


<210> 53
<211> 3295
<212> DNA
<213> Homo sapiens

<400> 53
attcgggccg ggcctcgctg cggcggcgac tgagccaggc tgggccgcgt ccctgagtcc       60

cagagtcggc gcggcgcggc aggggcagcc ttccaccacg gggagcccag ctgtcagccg      120

cctcacagga agatgctgcg tcggcggggc agccctggca tgggtgtgca tgtgggtgca      180

gccctgggag cactgtggtt ctgcctcaca ggagccctgg aggtccaggt ccctgaagac      240

ccagtggtgg cactggtggg caccgatgcc accctgtgct gctccttctc ccctgagcct      300

ggcttcagcc tggcacagct caacctcatc tggcagctga cagataccaa acagctggtg      360

cacagctttg ctgagggcca ggaccagggc agcgcctatg ccaaccgcac ggccctcttc      420

ccggacctgc tggcacaggg caacgcatcc ctgaggctgc agcgcgtgcg tgtggcggac      480

gagggcagct tcacctgctt cgtgagcatc cgggatttcg gcagcgctgc cgtcagcctg      540

caggtggccg ctccctactc gaagcccagc atgaccctgg agcccaacaa ggacctgcgg      600

ccaggggaca cggtgaccat cacgtgctcc agctaccagg gctaccctga ggctgaggtg      660

ttctggcagg atgggcaggg tgtgcccctg actggcaacg tgaccacgtc gcagatggcc      720

aacgagcagg gcttgtttga tgtgcacagc atcctgcggg tggtgctggg tgcaaatggc      780

acctacagct gcctggtgcg caaccccgtg ctgcagcagg atgcgcacag ctctgtcacc      840

atcacacccc agagaagccc cacaggagcc gtggaggtcc aggtccctga ggacccggtg      900

gtggccctag tgggcaccga tgccaccctg cgctgctcct tctcccccga gcctggcttc      960

agcctggcac agctcaacct catctggcag ctgacagaca ccaaacagct ggtgcacagt     1020

ttcaccgaag gccgggacca gggcagcgcc tatgccaacc gcacggccct cttcccggac     1080

ctgctggcac aaggcaatgc atccctgagg ctgcagcgcg tgcgtgtggc ggacgagggc     1140

agcttcacct gcttcgtgag catccgggat ttcggcagcg ctgccgtcag cctgcaggtg     1200

gccgctccct actcgaagcc cagcatgacc ctggagccca acaaggacct gcggccaggg     1260

gacacggtga ccatcacgtg ctccagctac cggggctacc ctgaggctga ggtgttctgg     1320

caggatgggc agggtgtgcc cctgactggc aacgtgacca cgtcgcagat ggccaacgag     1380

cagggcttgt ttgatgtgca cagcgtcctg cgggtggtgc tgggtgcgaa tggcacctac     1440

agctgcctgg tgcgcaaccc cgtgctgcag caggatgcgc acggctctgt caccatcaca     1500

gggcagccta tgacattccc cccagaggcc ctgtgggtga ccgtggggct gtctgtctgt     1560

ctcattgcac tgctggtggc cctggctttc gtgtgctgga gaaagatcaa acagagctgt     1620

gaggaggaga atgcaggagc tgaggaccag gatggggagg gagaaggctc caagacagcc     1680

ctgcagcctc tgaaacactc tgacagcaaa gaagatgatg gacaagaaat agcctgacca     1740

tgaggaccag ggagctgcta cccctcccta cagctcctac cctctggctg caatggggct     1800

gcactgtgag ccctgccccc aacagatgca tcctgctctg acaggtgggc tccttctcca     1860

aaggatgcga tacacagacc actgtgcagc cttatttctc caatggacat gattcccaag     1920

tcatcctgct gccttttttc ttatagacac aatgaacaga ccacccacaa ccttagttct     1980

ctaagtcatc ctgcctgctg ccttatttca cagtacatac atttcttagg gacacagtac     2040

actgaccaca tcaccaccct cttcttccag tgctgcgtgg accatctggc tgcctttttt     2100

ctccaaaaga tgcaatattc agactgactg accccctgcc ttatttcacc aaagacacga     2160

tgcatagtca ccccggcctt gtttctccaa tggccgtgat acactagtga tcatgttcag     2220

ccctgcttcc acctgcatag aatcttttct tctcagacag ggacagtgcg gcctcaacat     2280

ctcctggagt ctagaagctg tttcctttcc cctccttcct cctcttgctc tagccttaat     2340

actggccttt tccctccctg ccccaagtga agacagggca ctctgcgccc accacatgca     2400

cagctgtgca tggagacctg caggtgcacg tgctggaaca cgtgtggttc ccccctggcc     2460

cagcctcctc tgcagtgccc ctctcccctg cccatcctcc ccacggaagc atgtgctggt     2520

cacactggtt ctccaggggt ctgtgatggg gcccctgggg gtcagcttct gtccctctgc     2580

cttctcacct ctttgttcct ttcttttcat gtatccattc agttgatgtt tattgagcaa     2640

ctacagatgt cagcactgtg ttaggtgctg ggggccctgc gtgggaagat aaagttcctc     2700

cctcaaggac tccccatcca gctgggagac agacaactaa ctacactgca ccctgcggtt     2760

tgcagggggc tcctgcctgg ctccctgctc cacacctcct ctgtggctca aggcttcctg     2820

gatacctcac ccccatccca cccataattc ttacccagag catggggttg gggcggaaac     2880

ctggagagag ggacatagcc cctcgccacg gctagagaat ctggtggtgt ccaaaatgtc     2940

tgtccaggtg tgggcaggtg ggcaggcacc aaggccctct ggacctttca tagcagcaga     3000

aaaggcagag cctggggcag ggcagggcca ggaatgcttt ggggacaccg aggggactgc     3060

cccccacccc caccatggtg ctattctggg gctggggcag tcttttcctg gcttgcctct     3120

ggccagctcc tggcctctgg tagagtgaga cttcagacgt tctgatgcct tccggatgtc     3180

atctctccct gccccaggaa tggaagatgt gaggacttct aatttaaatg tgggactcgg     3240

agggattttg taaactgggg gtatattttg gggaaaataa atgtctttgt aaaaa          3295


<210> 54
<211> 534
<212> PRT
<213> Homo sapiens

<400> 54
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210> 55
<211> 3197
<212> DNA
<213> Mus musculus

<400> 55
cggcgcggcg cgccaaagtg acctggtaca gcctggaccc caagctcatc ggctttgtct       60

ggctggccgc ctggcctctt cccacttgga tttggatgat cctgaggcct ttggaggaac      120

ttcgagacaa aggcccctct tcctcttcca cgggcaggag cagccattcg ccacggagag      180

cccagctgtc agctgtctca caggaagatg cttcgaggat ggggtggccc cagtgtgggt      240

gtgtgtgtgc gcacagcact gggggtgctg tgcctctgcc tcacaggagc tgtggaagtc      300

caggtctctg aagaccccgt ggtggccctg gtggacacgg atgccaccct acgctgctcc      360

ttttccccag agcctggctt cagtctggca cagctcaacc tcatctggca gctgacagac      420

accaaacagc tggtgcacag cttcacggag ggccgggacc aaggcagtgc ctactccaac      480

cgcacagcgc tcttccctga cctgttggtg caaggcaatg cgtccttgag gctgcagcgc      540

gtccgagtaa ccgacgaggg cagctacacc tgctttgtga gcatccagga ctttgacagc      600

gctgctgtta gcctgcaggt ggccgccccc tactcgaagc ccagcatgac cctggagccc      660

aacaaggacc tacgtccagg gaacatggtg accatcacgt gctctagcta ccagggctat      720

ccggaggccg aggtgttctg gaaggatgga cagggagtgc ccttgactgg caatgtgacc      780

acatcccaga tggccaacga gcggggcttg ttcgatgttc acagcgtgct gagggtggtg      840

ctgggtgcta acggcaccta cagctgcctg gtacgcaacc cggtgttgca gcaagatgct      900

cacggctcag tcaccatcac agggcagccc ctgacattcc cccctgaggc tctgtgggta      960

accgtggggc tctctgtctg tcttgtggta ctactggtgg ccctggcttt cgtgtgctgg     1020

agaaagatca agcagagctg cgaggaggag aatgcaggtg ccgaggacca ggatggagat     1080

ggagaaggat ccaagacagc tctacggcct ctgaaaccct ctgaaaacaa agaagatgac     1140

ggacaagaaa ttgcttgatt gggagctgct gcccttccca ggtggggggc ccaccctctg     1200

gcagtgttga gcttcaatgc gagcccttcc cccaacgaat gggtttgtcc cacagatcta     1260

cccgttcgtc aaaggacgtg gtccatagac cacccacagc cttacttttc caatggactt     1320

aattcccatc atcctgcagc ctcatttctc cagtgacacg atacacgaac catcctgcgg     1380

ccttatttcc cacggacacg acacaaagat gtccctcctc ggtgttcctc cagagtcgtc     1440

tggtggcctt gtgatacggc gtgaaccttc ttccttctgc cttacgtcta atggacacac     1500

acgcaccacc cccacaccct tgctcctcca aagccatgca gactgtgtaa ctgctattat     1560

tctccaaggg gcatcctgtg cagatgaaac cctgctttat ttccctgaag acagctgcac     1620

agtgacctct tagttcttgc tcccatggcc ctgatgtatc ctagttacca gccctcaacc     1680

tcagttctga gggtgggatc ccatcgctca gcaaggcttc atcctgacct ccctgccctg     1740

atctgatctg gccctggctt ttgttgtctc gctccctgac taagtgagat ggggcactct     1800

cccgcccccg ccccccccag gtcacagata cctacctgca gctgtgcgtg ctggatcacg     1860

cacatacttg ccttgcatgg tctcctggct gccctgggct gtgcctgttc ttccatagga     1920

agcaagttct tgtctccctg gttctcaggg cccctcaggg gctcagcctt cagccctgtg     1980

cttccccatg ttgggaatct ttgttacctt tttcttcttt gtaaattaac atctgataac     2040

aaccacaggg tccaatggga ctttcacaga cctgccagct agataaataa tgacaacaga     2100

agtttattaa tattttaaga cttaggcctt ttgctgggca gcctcccaac tattctatcc     2160

tgactaatcc tggcactatg tcccaccaca tggccaggtc tacctctctg ctccactctc     2220

catccacctc catgtctgcc agcaaatctc ccgtgattca gttcttctcc cagagtccct     2280

atctctgccc agaagtacca tcttcgactt cctgcccaac tattggccgt cagctcttca     2340

ttaaagccga tcagatgtaa ttctagattg ccttaggcag gtgaggaaga aacaagtatt     2400

tgtaaaatat gagaccagca atgggccata gaaataacag caccagatcc tgccagcatt     2460

tagccctctg ttggtacaaa attaacaatt gaatatacag agacctactt ccagagtgta     2520

ccccaacaac aggcgtgagc atggtgctgg gtactagggt cctgctggaa aatcagagac     2580

cttacctaca gctgggacat gaccttgctt ccgacttacc caccacttct ggatacctca     2640

ccctcagccc acactatccc tggcctaggg cccagggtag agccagaaac atggagaaag     2700

catggcccct tgccgtacct ggagaactgg gtattttcca gagtctttat agatgtggac     2760

tggaaggcag gtggccacag ccgtgcagac ctgggtcagg tcagaaacct atgccatgct     2820

gggacctact caacagcaga agcatgaaga gggcctgagg acaagaaagg ccttcttacc     2880

atggtgctat tctggagctg ggatatatac ctggcttgtc tctgactgcc ctggcttctg     2940

gcagaacttc tgatgtcctc ctgaaggcct ctctcccacc ccagtacctg agaacctgag     3000

gataatttaa acatgggact ctggccagca cctgggagag acaggtagat ctctgatttt     3060

tgactcagcc tggtctatcg agtgagttcc aggacatctg gggctacaca gagaaaccat     3120

cttaaagact aaaaataata aacatgagac tgtaaactgg gtgtattttg ggagaaataa     3180

atgtcttttt ctttcaa                                                    3197


<210> 56
<211> 316
<212> PRT
<213> Mus musculus

<400> 56
Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Cys Val Arg Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Ser Glu Asp Pro Val Val Ala Leu Val Asp Thr Asp Ala Thr Leu 
        35                  40                  45              


Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr 
65                  70                  75                  80  


Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ser Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Val Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Thr Asp Glu Gly Ser Tyr Thr Cys Phe Val Ser Ile Gln Asp 
        115                 120                 125             


Phe Asp Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asn Met 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Lys Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Arg Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Leu Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Val Val Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Asp Gly Glu Gly Ser Lys Thr Ala Leu Arg Pro Leu Lys Pro 
    290                 295                 300                 


Ser Glu Asn Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210> 57
<211> 2605
<212> DNA
<213> Homo sapiens

<400> 57
gtgagtcacc aaggaaggca gcggcagctc cactcagcca gtacccagat acgctgggaa       60

ccttccccag ccatggcttc cctggggcag atcctcttct ggagcataat tagcatcatc      120

attattctgg ctggagcaat tgcactcatc attggctttg gtatttcagg gagacactcc      180

atcacagtca ctactgtcgc ctcagctggg aacattgggg aggatggaat cctgagctgc      240

acttttgaac ctgacatcaa actttctgat atcgtgatac aatggctgaa ggaaggtgtt      300

ttaggcttgg tccatgagtt caaagaaggc aaagatgagc tgtcggagca ggatgaaatg      360

ttcagaggcc ggacagcagt gtttgctgat caagtgatag ttggcaatgc ctctttgcgg      420

ctgaaaaacg tgcaactcac agatgctggc acctacaaat gttatatcat cacttctaaa      480

ggcaagggga atgctaacct tgagtataaa actggagcct tcagcatgcc ggaagtgaat      540

gtggactata atgccagctc agagaccttg cggtgtgagg ctccccgatg gttcccccag      600

cccacagtgg tctgggcatc ccaagttgac cagggagcca acttctcgga agtctccaat      660

accagctttg agctgaactc tgagaatgtg accatgaagg ttgtgtctgt gctctacaat      720

gttacgatca acaacacata ctcctgtatg attgaaaatg acattgccaa agcaacaggg      780

gatatcaaag tgacagaatc ggagatcaaa aggcggagtc acctacagct gctaaactca      840

aaggcttctc tgtgtgtctc ttctttcttt gccatcagct gggcacttct gcctctcagc      900

ccttacctga tgctaaaata atgtgcctcg gccacaaaaa agcatgcaaa gtcattgtta      960

caacagggat ctacagaact atttcaccac cagatatgac ctagttttat atttctggga     1020

ggaaatgaat tcatatctag aagtctggag tgagcaaaca agagcaagaa acaaaaagaa     1080

gccaaaagca gaaggctcca atatgaacaa gataaatcta tcttcaaaga catattagaa     1140

gttgggaaaa taattcatgt gaactagaca agtgtgttaa gagtgataag taaaatgcac     1200

gtggagacaa gtgcatcccc agatctcagg gacctccccc tgcctgtcac ctggggagtg     1260

agaggacagg atagtgcatg ttctttgtct ctgaattttt agttatatgt gctgtaatgt     1320

tgctctgagg aagcccctgg aaagtctatc ccaacatatc cacatcttat attccacaaa     1380

ttaagctgta gtatgtaccc taagacgctg ctaattgact gccacttcgc aactcagggg     1440

cggctgcatt ttagtaatgg gtcaaatgat tcacttttta tgatgcttcc aaaggtgcct     1500

tggcttctct tcccaactga caaatgccaa agttgagaaa aatgatcata attttagcat     1560

aaacagagca gtcggcgaca ccgattttat aaataaactg agcaccttct ttttaaacaa     1620

acaaatgcgg gtttatttct cagatgatgt tcatccgtga atggtccagg gaaggacctt     1680

tcaccttgtc tatatggcat tatgtcatca caagctctga ggcttctcct ttccatcctg     1740

cgtggacagc taagacctca gttttcaata gcatctagag cagtgggact cagctggggt     1800

gatttcgccc cccatctccg ggggaatgtc tgaagacaat tttggttacc tcaatgaggg     1860

agtggaggag gatacagtgc tactaccaac tagtggatag aggccaggga tgctgctcaa     1920

cctcctacca tgtacaggac gtctccccat tacaactacc caatccgaag tgtcaactgt     1980

gtcagggcta agaaaccctg gttttgagta gaaaagggcc tggaaagagg ggagccaaca     2040

aatctgtctg cttcctcaca ttagtcattg gcaaataagc attctgtctc tttggctgct     2100

gcctcagcac agagagccag aactctatcg ggcaccagga taacatctct cagtgaacag     2160

agttgacaag gcctatggga aatgcctgat gggattatct tcagcttgtt gagcttctaa     2220

gtttctttcc cttcattcta ccctgcaagc caagttctgt aagagaaatg cctgagttct     2280

agctcaggtt ttcttactct gaatttagat ctccagaccc tgcctggcca caattcaaat     2340

taaggcaaca aacatatacc ttccatgaag cacacacaga cttttgaaag caaggacaat     2400

gactgcttga attgaggcct tgaggaatga agctttgaag gaaaagaata ctttgtttcc     2460

agcccccttc ccacactctt catgtgttaa ccactgcctt cctggacctt ggagccacgg     2520

tgactgtatt acatgttgtt atagaaaact gattttagag ttctgatcgt tcaagagaat     2580

gattaaatat acatttccta cacca                                           2605


<210> 58
<211> 282
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210> 59
<211> 2622
<212> DNA
<213> Mus musculus

<400> 59
gtgagtcaca acacccagga gggcagcagc aggcaggcag ctccactcac caaaatctgg       60

ccccacacac agcaggactg tgggaaggaa ctccctctcc atggcttcct tggggcagat      120

catcttttgg agtattatta acatcatcat catcctggct ggggccatcg cactcatcat      180

tggctttggc atttcaggca agcacttcat cacggtcacg accttcacct cagctggaaa      240

cattggagag gacgggaccc tgagctgcac ttttgaacct gacatcaaac tcaacggcat      300

cgtcatccag tggctgaaag aaggcatcaa aggtttggtc cacgagttca aagaaggcaa      360

agacgacctc tcacagcagc atgagatgtt cagaggccgc acagcagtgt ttgctgatca      420

ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg cagctcacgg atgctggcac      480

ctacacatgt tacatccgca cctcaaaagg caaagggaat gcaaaccttg agtataagac      540

cggagccttc agtatgccag agataaatgt ggactataat gccagttcag agagtttacg      600

ctgcgaggct cctcggtggt tcccccagcc cacagtggcc tgggcatctc aagtcgacca      660

aggagccaat ttctcagaag tctccaacac cagctttgag ttgaactctg agaatgtgac      720

catgaaggtc gtatctgtgc tctacaatgt cacaatcaac aacacatact cctgtatgat      780

tgaaaacgac attgccaaag ccaccgggga catcaaagtg acagattcag aggtcaaaag      840

gcgaagtcag ctgcagttgc tgaactctgg gccttccccg tgtgtttttt cttctgcctt      900

tgtggctggc tgggcactcc tatctctctc ctgttgcctg atgctaagat gaggggccct      960

ggctacacaa aagcatgcaa cgttgctggt ccaacagaat cccggagaac tacagaaata     1020

ttttcctcaa gacatgacct agttttatat ttctagaaga agatgaaatc atgtctagaa     1080

gtctggagag agcagacagg aacaagatgt ggaaggaaaa caaaagtaac ccacagacac     1140

ccccgatcgg aacaagatgg acctagaaaa taattcaacc aaactagagt atactaagtg     1200

tgctgttaca atgtgtgtag ggtaggtgtc ctcccacatc tcaggggcct cccctggtcc     1260

accagctcct gagttaggat gggctgttat gatgtcactc tgaaggttcc tggatggttc     1320

ctactgccat atactcattt tatattcagc acattaaacc atagtgaatg ctatgaaaag     1380

ctgctaatca gctgccactc cgagattcgg aggtggcaac gtctgagtga caggtccagt     1440

gattcgcttc tccttaggat gcttttacaa gctctttggc gtctcctccc acctggcaaa     1500

tgccaaatgc ataggggagg gtgatcatca ttctagggca aacaaaatag ttgagggatg     1560

ctgatttccc aaatcatccg aatcacttct cccttgagca aacaagcgcc ctgttatttc     1620

tcaaatgctg ctttgtgaat cagtccaggg caaggcgctc tcctcatccc gctatgtggc     1680

cttaagtcat cgtaaggttt gaagtttcta ctttcgatcc tgcatggaga gctataatct     1740

cagctccccc gcccccccca cacacacctc tgcacacaca ccccccccca acactgggag     1800

taaaccagga tgatgtccgt cttctcattc cccatgtgac cgttggcagt gtagagagac     1860

tgattgtcac agctaaagga agagggacaa cagggtcact ggtgtctaca gagattatat     1920

tctacgtgtc tcactgaatt tacacaactc caagtgccaa ccacatcaag gtcaggaaat     1980

cctgaactgg aataagaaag acccagaaga tgaatgtgaa cagatccatt tgcttcccga     2040

cagtgggcac agacttcagt ctctggctac tgttccaaga cccagggctc tgcaattgtg     2100

tgacatcctt cagtgaaccc acatgggaaa ttctccatgg aattatcttc agcccactgt     2160

acttctgaat ccctcttcct tccttctgtg ccacacagca agtctggctt aaatgctgcc     2220

tgatctccat ttcaagtttt ctgcctctgg atttttagat ctcaagacca tggacgaaac     2280

atcagttaca gcaacaaaag tgaattttcc gtgcagagac ttctaggggt tctgtttgtt     2340

ttcagggtgc tagagatcac actcagatgc tcatatatgt taggtaaatg ttctcccact     2400

gagttacagc ccagctcaca cagagacttc taaaagaaaa tacggccatg ctctttgaaa     2460

tggagcattg agggatgaag tttggatggc gaagaaaact tctcaccagc tctctcccca     2520

cattcgtgcc aagcactgcc tccctagact tcgggtcacc atatctgtac tacgttttga     2580

tacagaaggc tcgagaccat tcaagagaat tatttagtac ac                        2622


<210> 60
<211> 283
<212> PRT
<213> Mus musculus

<400> 60
Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Pro Ser Pro Cys Val Phe Ser Ser Ala Phe Val Ala Gly Trp Ala 
            260                 265                 270         


Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
        275                 280             


<210> 61
<211> 4714
<212> DNA
<213> Homo sapiens

<400> 61
agtcgcggga ggcttccccg cgccggccgc gtcccgcccg ctccccggca ccagaagttc       60

ctctgcgcgt ccgacggcga catgggcgtc cccacggccc tggaggccgg cagctggcgc      120

tggggatccc tgctcttcgc tctcttcctg gctgcgtccc taggtccggt ggcagccttc      180

aaggtcgcca cgccgtattc cctgtatgtc tgtcccgagg ggcagaacgt caccctcacc      240

tgcaggctct tgggccctgt ggacaaaggg cacgatgtga ccttctacaa gacgtggtac      300

cgcagctcga ggggcgaggt gcagacctgc tcagagcgcc ggcccatccg caacctcacg      360

ttccaggacc ttcacctgca ccatggaggc caccaggctg ccaacaccag ccacgacctg      420

gctcagcgcc acgggctgga gtcggcctcc gaccaccatg gcaacttctc catcaccatg      480

cgcaacctga ccctgctgga tagcggcctc tactgctgcc tggtggtgga gatcaggcac      540

caccactcgg agcacagggt ccatggtgcc atggagctgc aggtgcagac aggcaaagat      600

gcaccatcca actgtgtggt gtacccatcc tcctcccagg atagtgaaaa catcacggct      660

gcagccctgg ctacgggtgc ctgcatcgta ggaatcctct gcctccccct catcctgctc      720

ctggtctaca agcaaaggca ggcagcctcc aaccgccgtg cccaggagct ggtgcggatg      780

gacagcaaca ttcaagggat tgaaaacccc ggctttgaag cctcaccacc tgcccagggg      840

atacccgagg ccaaagtcag gcaccccctg tcctatgtgg cccagcggca gccttctgag      900

tctgggcggc atctgctttc ggagcccagc acccccctgt ctcctccagg ccccggagac      960

gtcttcttcc catccctgga ccctgtccct gactctccaa actttgaggt catctagccc     1020

agctggggga cagtgggctg ttgtggctgg gtctggggca ggtgcatttg agccagggct     1080

ggctctgtga gtggcctcct tggcctcggc cctggttccc tccctcctgc tctgggctca     1140

gatactgtga catcccagaa gcccagcccc tcaacccctc tggatgctac atggggatgc     1200

tggacggctc agcccctgtt ccaaggattt tggggtgctg agattctccc ctagagacct     1260

gaaattcacc agctacagat gccaaatgac ttacatctta agaagtctca gaacgtccag     1320

cccttcagca gctctcgttc tgagacatga gccttgggat gtggcagcat cagtgggaca     1380

agatggacac tgggccaccc tcccaggcac cagacacagg gcacggtgga gagacttctc     1440

ccccgtggcc gccttggctc ccccgttttg cccgaggctg ctcttctgtc agacttcctc     1500

tttgtaccac agtggctctg gggccaggcc tgcctgccca ctggccatcg ccaccttccc     1560

cagctgcctc ctaccagcag tttctctgaa gatctgtcaa caggttaagt caatctgggg     1620

cttccactgc ctgcattcca gtccccagag cttggtggtc ccgaaacggg aagtacatat     1680

tggggcatgg tggcctccgt gagcaaatgg tgtcttgggc aatctgaggc caggacagat     1740

gttgccccac ccactggaga tggtgctgag ggaggtgggt ggggccttct gggaaggtga     1800

gtggagaggg gcacctgccc cccgccctcc ccatccccta ctcccactgc tcagcgcggg     1860

ccattgcaag ggtgccacac aatgtcttgt ccaccctggg acacttctga gtatgaagcg     1920

ggatgctatt aaaaactaca tggggaaaca ggtgcaaacc ctggagatgg attgtaagag     1980

ccagtttaaa tctgcactct gctgctcctc ccccaccccc accttccact ccatacaatc     2040

tgggcctggt ggagtcttcg cttcagagcc attcggccag gtgcgggtga tgttcccatc     2100

tcctgcttgt gggcatgccc tggctttgtt tttatacaca taggcaaggt gagtcctctg     2160

tggaattgtg attgaaggat tttaaagcag gggaggagag tagggggcat ctctgtacac     2220

tctgggggta aaacagggaa ggcagtgcct gagcatgggg acaggtgagg tggggctggg     2280

cagaccccct gtagcgttta gcaggatggg ggccccaggt actgtggaga gcatagtcca     2340

gcctgggcat ttgtctccta gcagcctaca ctggctctgc tgagctgggc ctgggtgctg     2400

aaagccagga tttggggcta ggcgggaaga tgttcgccca attgcttggg gggttggggg     2460

gatggaaaag gggagcacct ctaggctgcc tggcagcagt gagccctggg cctgtggcta     2520

cagccaggga accccacctg gacacatggc cctgcttcta agccccccag ttaggcccaa     2580

aggaatggtc cactgagggc ctcctgctct gcctgggctg ggccaggggc tttgaggaga     2640

gggtaaacat aggcccggag atggggctga cacctcgagt ggccagaata tgcccaaacc     2700

ccggcttctc ccttgtccct aggcagaggg gggtcccttc ttttgttccc tctggtcacc     2760

acaatgcttg atgccagctg ccataggaag agggtgctgg ctggccatgg tggcacacac     2820

ctgtcctccc agcactttgc agggctgagg tggaaggacc gcttaagccc aggtgttcaa     2880

ggctgctgtg agctgtgttc gagccactac actccagcct ggggacggag caaaactttg     2940

cctcaaaaca aattttaaaa agaaagaaag aaggaaagag ggtatgtttt tcacaattca     3000

tgggggcctg catggcagga gtggggacag gacacctgct gttcctggag tcgaaggaca     3060

agcccacagc ccagattccg gttctcccaa ctcaggaaga gcatgccctg ccctctgggg     3120

aggctggcct ggccccagcc ctcagctgct gaccttgagg cagagacaac ttctaagaat     3180

ttggctgcca gaccccaggc ctggctgctg ctgtgtggag agggaggcgg cccgcagcag     3240

aacagccacc gcacttcctc ctcagcttcc tctggtgcgg ccctgccctc tcttctctgg     3300

acccttttac aactgaacgc atctgggctt cgtggtttcc tgttttcagc gaaatttact     3360

ctgagctccc agttccatct tcatccatgg ccacaggccc tgcctacaac gcactaggga     3420

cgtccctccc tgctgctgct ggggaggggc aggctgctgg agccgccctc tgagttgccc     3480

gggatggtag tgcctctgat gccagccctg gtggctgtgg gctggggtgc atgggagagc     3540

tgggtgcgag aacatggcgc ctccaggggg cgggaggagc actaggggct ggggcaggag     3600

gctcctggag cgctggattc gtggcacagt ctgaggccct gagagggaaa tccatgcttt     3660

taagaactaa ttcattgtta ggagatcaat caggaattag gggccatctt acctatctcc     3720

tgacattcac agtttaatag agacttcctg cctttattcc ctcccaggga gaggctgaag     3780

gaatggaatt gaaagcacca tttggagggt tttgctgaca cagcggggac tgctcagcac     3840

tccctaaaaa cacaccatgg aggccactgg tgactgctgg tgggcaggct ggccctgcct     3900

gggggagtcc gtggcgatgg gcgctggggt ggaggtgcag gagccccagg acctgctttt     3960

caaaagactt ctgcctgacc agagctccca ctacatgcag tggcccaggg cagaggggct     4020

gatacatggc ctttttcagg gggtgctcct cgcggggtgg acttgggagt gtgcagtggg     4080

acagggggct gcaggggtcc tgccaccacc gagcaccaac ttggcccctg gggtcctgcc     4140

tcatgaatga ggccttcccc agggctggcc tgactgtgct gggggctggg ttaacgtttt     4200

ctcagggaac cacaatgcac gaaagaggaa ctggggttgc taaccaggat gctgggaaca     4260

aaggcctctt gaagcccagc cacagcccag ctgagcatga ggcccagccc atagacggca     4320

caggccacct ggcccattcc ctgggcattc cctgctttgc attgctgctt ctcttcaccc     4380

catggaggct atgtcaccct aactatcctg gaatgtgttg agagggattc tgaatgatca     4440

atatagcttg gtgagacagt gccgagatag atagccatgt ctgccttggg cacgggagag     4500

ggaagtggca gcatgcatgc tgtttcttgg ccttttctgt tagaatactt ggtgctttcc     4560

aacacacttt cacatgtgtt gtaacttgtt tgatccaccc ccttccctga aaatcctggg     4620

aggttttatt gctgccattt aacacagagg gcaatagagg ttctgaaagg tctgtgtctt     4680

gtcaaaacaa gtaaacggtg gaactacgac taaa                                 4714


<210> 62
<211> 311
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210> 63
<211> 4846
<212> DNA
<213> Mus musculus

<400> 63
gggggcgctg ctgggcgggg agcttgctcg gccgcctgcc tcgccttggg ctcagcattc       60

actctagcga gcgagcggcg tgtacagccg gctccctggg ctcctggagt cccgcttgct      120

ccaagcgcac tccagcagtc tctttctgct cttgcccggc tcgacggcga catgggtgtc      180

cccgcggtcc cagaggccag cagcccgcgc tggggaaccc tgctccttgc tattttcctg      240

gctgcatcca gaggtctggt agcagccttc aaggtcacca ctccatattc tctctatgtg      300

tgtcccgagg gacagaatgc caccctcacc tgcaggattc tgggccccgt gtccaaaggg      360

cacgatgtga ccatctacaa gacgtggtac ctcagctcac gaggcgaggt ccagatgtgc      420

aaagaacacc ggcccatacg caacttcaca ttgcagcacc ttcagcacca cggaagccac      480

ctgaaagcca acgccagcca tgaccagccc cagaagcatg ggctagagct agcttctgac      540

caccacggta acttctctat caccctgcgc aatgtgaccc caagggacag cggcctctac      600

tgctgtctag tgatagaatt aaaaaaccac cacccagaac aacggttcta cgggtccatg      660

gagctacagg tacaggcagg caaaggctcg gggtccacat gcatggcgtc taatgagcag      720

gacagtgaca gcatcacggc tgcggccctg gccaccggcg cctgcatcgt gggaatcctc      780

tgcctccccc ttatcctgct gctggtctat aagcagagac aggtggcctc tcaccgccgt      840

gcccaggagt tggtgaggat ggacagcagc aacacccaag gaatcgaaaa cccaggcttc      900

gagaccactc cacccttcca ggggatgcct gaggccaaga ccaggccgcc actgtcctat      960

gtggcccagc ggcaaccttc ggagtcagga cggtacctgc tctctgaccc cagcacacct     1020

ctgtcgcctc caggccctgg ggacgtcttt ttcccatccc tagatccagt ccctgactcc     1080

cctaactctg aagccatcta aaccagctgg ggaaccatga accatggtac ctgggtcagg     1140

gatatgtgca cttgatctat ggctggccct tggacagtct tttaggcact gactccagct     1200

tccttgctcc tgctctgagc ctagactctg cttttacaag atgcacagac cctcccctat     1260

ctctttcaga cgctacttgg ggggcaggga gaagatgttg gattgctcat tgctgttctc     1320

aagatcttgg gatgctgagt tctccctaga gacttgactt cgacagccac agatgtcaga     1380

tgacctgcat cctatgaacg tccggcttgg caagagcctt tcttcatgga aaccagtagc     1440

ccggagggga tgaggtaggc accttgccac cctcccggga gagagacaca agatgtgaga     1500

gactcctgct cactgtgggg gtgtggctgg cctgcttgtt tgcctgagga tgctcctctg     1560

ttggactgac tctatccccc tggattctgg agcttggctg gcctatgtcc caccagagga     1620

gcatctcagc agccttccac cagcaacctg agggcctgcc agcttcgtgg ctctgggctc     1680

tcattacctg tatggccgtc cacagagctc agtggccaga ggctttgaaa caggaagtac     1740

atgtcaggtt caggaaccac tgtgagctca ttagtgtctt gagcaatgtg aggcctggac     1800

cagtggacac ggagggaggg tggcgagagg atgatgggga tgatgagggg aacacgctcc     1860

cttcctgtcc ttgtcatcca ccactaccac tattcagtgt ggagcagtgg caaaggtgac     1920

cgacctccac aatgtcctag tgatgctgga ccatttctaa gtgtgaaaga gatgctatta     1980

aaaacagtat gtggcaatgg ctgccaacag ctgagtggac tggaggcact ggctttaagg     2040

ccctggaggt gcagggcccg gtatggggat agggatggga gtttcagtga gggcctaggg     2100

atcactccgc ttctgaccac tcttcttctg agcctcacct cagggtgacc ttcaggcaca     2160

cagaagagct tgcccctggt ccgatactac tcttggctct catctccagg gtttggcatg     2220

acctgggcac acagggggag tcttcagaaa ggattttaaa gcatgaaaag aaagggtagt     2280

tcttgtgagg tagggatggg cagctgatgt ttgagagtga ggagggatac ggctgggcag     2340

atcactctcc agtctctaga gggaaagtag ctctaagtct gggagagcag cagcccagtg     2400

gtaccatatg tcttcttgca gcttccactg gctgggctga actgggcatg ggtaggaaag     2460

ctcctgttct gggcctgcag ccagggagaa ccccattcat tccctgagga cagatgggtg     2520

gggagagaag agagagtttc aggccgggaa gcagcaataa gctatctgct ggggacccag     2580

acaagttgtc tgatgaggtc caagatgtgg gatgccagtt atacctgggg cttggggatc     2640

cttagaggct ttgtatcatc atcataggag tgtcggggtg gccagggcat caaagccatg     2700

acccctgttt tatcctcagg gtccactctt ctgcaccatc cattgctcta gatctatgca     2760

gttactatag acagaatgtg ttgttctgtt tggctttggg gataatggcc tggcgaactg     2820

ccagctgttc agtggcaggg ctgtgaggcc agtcaaagac tagaacccac agaccagctg     2880

aacgatgagt atagcctgtc ccctggggga gcctgacctg tctccagccc taagcttcag     2940

acctcaccac tcagatgact tctaagaatt tgcctgtggg gacccctgca tggctgcagc     3000

tccgtggaaa ggagaggagg cccccagcag aagaaccact cgcttcctgc ccagcttcct     3060

cctgtagggc tctaagtctc ttcttcttgg gaccctgcaa gcaaaggcat gtcagcttgg     3120

tggtttcctg ttttgggtga agttttgtgt ggtccgggtt ctgtctacat ccatgaactt     3180

gggtgctacc accttgctgc tgctgtagag acagctgcag gatcttaggg tggaaaatgg     3240

aggtgccctg aggtgctagc ccttggggca aaagatgggg tggcaatgag acacagtggg     3300

gaactgagtt ccccaagagg agggaggagc cctgtagcct caagggccat attgggttcc     3360

tggtaccagc aaaagcctag agagcgaagt ctgtattttg aggaggtaat tgatccttac     3420

ggaatccatc agaaatttgg agcgggtgct ttatctatct ctggagggtc tctacctatc     3480

tccgatgaag ctctccctgg gcctgggatg ggagaaacca ggaggaaagg tgtctgataa     3540

agcaggggct tcttgacaag ccaaagggcc actggtagct gttgtggacc gagctgaccc     3600

tgctgaagta ttgtagtgtg ccttggacca acttctcaaa agagcaaccc cggggctacc     3660

ctacttctgc caggaagagg cggagaaggg gctgagaggc ctggaagggg ctagctcctt     3720

ctttgagaac tgctccccgg aggacttgga ggaggcggct aggctacggg ctgctgaggg     3780

ccctttgtct ttcctaacct gggcactgtt aggatgctcc ctcctggaaa aggctttcct     3840

gggtgtgagc tagagcagtg tccatgccag cgctgaacct gccatggtgg gagctgaact     3900

aaaaatttct cagggaacta aaataggcaa aagaggaact gggggaggag ggtgccaggc     3960

aggatggggg gaagggaggg cagtgcaaaa gtctcttgaa acacagacag cccagctgag     4020

tgccagtccc agatcacaga gaatacggct catctggctc atgttctgca tgcttgctgc     4080

tttaccctgg cactttcctt ctccaccatg agtgcgagtc ctgggagtcc tgggagggtg     4140

aggattaatg ccagcctggg gagcagatag ctgacagagt ccttgggtaa ctggcttgaa     4200

ccaggacctc aggattccac tctggggatc tagctttgtc tgggccagtg aagatctcta     4260

taatggcatt attgccaggg gataaacatt tcactgggtt ctgatctgtt gggtgtggct     4320

tcctggaaaa tatggtgaga ggaattctgc taaggataca gttgataaga aagttctgag     4380

attgattagt aatgcctgcc ttggactcag gaagggaagt ggcagtatga atgccatgtc     4440

ttaatcattt tggttaaaat atgcttccca aaagatttcc acgtgtgttc ttgtttattt     4500

gacatctgtc tccatatcag tcttgaaagc ctttctgtgt gtatatatat gatgtttgcg     4560

tgtatatatg tttttgtgtg tgcatatgga agtcagaaat cactgggtgt cttcctccat     4620

tcctttgcaa tgtatgtttt tttttttttt acgatttatt tactatatga atgttttgcc     4680

tgaatacatg cataggtgtc acgtacatgc ctgctggaac gcttggaact ggagttacag     4740

gtggctatga gctacagtgt gagcactggg aatcaaacct gggtcttctg caagagcaac     4800

aaattaaaag tcagctctta actacttgag ctatttttcc aactcc                    4846


<210> 64
<211> 309
<212> PRT
<213> Mus musculus

<400> 64
Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Ala Ala 
            180                 185                 190         


Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu Pro Leu Ile 
        195                 200                 205             


Leu Leu Leu Val Tyr Lys Gln Arg Gln Val Ala Ser His Arg Arg Ala 
    210                 215                 220                 


Gln Glu Leu Val Arg Met Asp Ser Ser Asn Thr Gln Gly Ile Glu Asn 
225                 230                 235                 240 


Pro Gly Phe Glu Thr Thr Pro Pro Phe Gln Gly Met Pro Glu Ala Lys 
                245                 250                 255     


Thr Arg Pro Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser Glu Ser 
            260                 265                 270         


Gly Arg Tyr Leu Leu Ser Asp Pro Ser Thr Pro Leu Ser Pro Pro Gly 
        275                 280                 285             


Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp Ser Pro 
    290                 295                 300                 


Asn Ser Glu Ala Ile 
305                 


<210> 65
<211> 2666
<212> DNA
<213> Homo sapiens

<400> 65
agttctcttc aagtcatgta atcgactttt ttgaattagt tttcagtttc attttgtttt       60

ccctaattca agttgggaac acttcatttt ccccaattca agttgggaac acttccttgg      120

tatttccttg ctacatggac tttagcaaat gctactttac tctccttcca gctactcagg      180

aggctgaggc aggagaatcg cttgaacccg ggaggcggag gttacagtga gccttttcct      240

agttttactg ttggaagcct aactcacagg agagattatg caatacagtc ctgaagtcaa      300

gggaggagag catgtaggag aatactaacc ctgcacagat tgtgatggtg atgtggaata      360

tactaaagcc tagaacgcac ctcctctgca tgactaatat gttctgcaca agacatgaag      420

gcacagacag cactgtcttt cttcctcatt ctcataacat ctctgagtgg atctcaaggc      480

atattccctt tggctttctt catttatgtt cctatgaatg aacaaatcgt cattggaaga      540

cttgatgaag atataattct cccttcttca tttgagaggg gatccgaagt cgtaatacac      600

tggaagtatc aagatagcta taaggttcac agttactaca aaggcagtga ccatttggaa      660

agccaagatc ccagatatgc aaacaggaca tcccttttct ataatgagat tcaaaatggg      720

aatgcgtcgc tatttttcag aagagtaagc cttctggacg aaggaattta cacctgctat      780

gtaggaacag caattcaagt gattacaaac aaagtggtgc taaaggtggg agtttttctc      840

acacccgtga tgaagtatga aaagaggaac acaaacagct tcttaatatg cagcgtgtta      900

agtgtttatc ctcgtccaat tatcacgtgg aaaatggaca acacacctat ctctgaaaac      960

aacatggaag aaacagggtc tttggattct ttttctatta acagcccact gaatattaca     1020

ggatcaaatt catcttatga atgtacaatt gaaaattcac tgctgaagca aacatggaca     1080

gggcgctgga cgatgaaaga tggccttcat aaaatgcaaa gtgaacacgt ttcactctca     1140

tgtcaacctg taaatgatta tttttcacca aaccaagact tcaaagttac ttggtccaga     1200

atgaaaagtg ggactttctc tgtcctggct tactatctga gctcctcaca aaatacaatt     1260

atcaatgaat cccgattctc atggaacaaa gagctgataa accagagtga cttctctatg     1320

aatttgatgg atcttaatct ttcagacagt ggggaatatt tatgcaatat ttcttcggat     1380

gaatatactt tacttaccat ccacacagtg catgtagaac cgagccaaga aacagcttcc     1440

cataacaaag gcttatggat tttggtgccc tctgcgattt tggcagcttt tctgctgatt     1500

tggagcgtaa aatgttgcag agcccagcta gaagccagga ggagcagaca ccctgctgat     1560

ggagcccaac aagaaagatg ttgtgtccct cctggtgagc gctgtcccag tgcacccgat     1620

aatggcgaag aaaatgtgcc tctttcagga aaagtatagg aaatgagaga agactgtgac     1680

aactcatgac ctgcatcctt aatatccagt gacttcatct cccctttctt caccacaatt     1740

ccaggcaatg gcctgtcgga gcagacaatt ctaccactgc aaagagttgt aaccattttc     1800

tggtatcaca tttatttttc aagacatact tttcaagaca tcattcactg acccactacc     1860

tgcattgagt ataaatgcct ggatgttaag gattccaatt taactttgaa aagaactgtc     1920

tcattcattt acatttctgt tacagtcagc ccaggaggtt acagtgagct ctccactaag     1980

aatctggaag aaatgcatca ctaggggttg attcccaatc tgatcaactg ataatgggtg     2040

agagagcagg taagagccaa agtcacctta gtggaaaggt taaaaaccag agcctggaaa     2100

ccaagatgat tgatttgaca aggtatttta gtctagtttt atatgaacgg ttgtatcagg     2160

gtaaccaact cgatttggga tgaatcttag ggcaccaaag actaagacag tatctttaag     2220

attgctaggg aaaagggccc tatgtgtcag gcctctgagc ccaagccaag catcgcatcc     2280

cctgtgattt gcacgtatac atccagatgg cctaaagtaa ctgaagatcc acaaaagaag     2340

taaaaatagc cttaactgat gacattccac cattgtgatt tgttcctgcc ccaccctaac     2400

tgatcaatgt actttgtaat ctcccccacc cttaagaagg tactttgtaa tcttccccac     2460

ccttaagaag gttctttgta attctcccca cccttgagaa tgtactttgt gagatccacc     2520

ctgcccacaa aacattgctc ttaacttcac cgcctaaccc aaaacctata agaactaatg     2580

ataatccatc acccttcgct gactctcttt tcggactcag cccacctgca cccaggtgaa     2640

ataaacagct ttattgctca cacaaa                                          2666


<210> 66
<211> 414
<212> PRT
<213> Homo sapiens

<400> 66
Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 


<210> 67
<211> 2113
<212> DNA
<213> Mus musculus

<400> 67
acccttaaat aagagctgaa gatggctgca gctttctcct agactcctcc aggagaaact       60

ctaaagccag agcctggggg cagcattgtg tgtccacctt gccactgaga acatctacgg      120

aaattggaca ctctggcccc agcatccaca cgcttgactg ttggccacag taacacaggt      180

gtggatggtc cccagagcca gggtccagga gtgcactgag gatccctggg gcttcaagga      240

acccacagct ctgtccagac gggaattttt ttcctgagaa ctttcacctg ttgccctcct      300

atggtgaacc tggacttgac cttccactct gatgatgaag ggctccccct ccgtccctcc      360

agctggttgt ctcctccctc tgctcctcct gctgtttacc ggagtctctg gagaagtgtc      420

ttggttttct gtgaagggac cagctgagcc catcactgtc ctgctgggga ctgaagccac      480

cctgccctgc cagctgtctc ctgaacagag tgcagctcgc atgcacatcc gatggtaccg      540

tgcccagccc acccctgctg tgctggtgtt ccacaacgga caggagcagg gagaggtgca      600

gatgccggaa tacaggggca ggacccagat ggtgagacaa gccattgaca tgggaagtgt      660

ggctctgcag atacagcagg tccaggcctc tgatgatggc ctgtaccact gtcagtttac      720

agatggcttc acctcccaag aggtctccat ggagcttcga gtcataggtt taggctctgc      780

ccctcttgtt cacatgacag gacctgagaa tgatgggatc cgagtgttgt gctcctcaag      840

tggctggttc ccaaaaccca aagtgcaatg gagagacacc tccgggaaca tgctactgtc      900

ctcctctgag ttgcagaccc aagacagaga agggctcttc caggtggaag tgtctctttt      960

ggtcacagat agagctattg gcaatgtgat ctgctccatc caaaatccca tgtatgacca     1020

ggagaaatcg aaggccatcc tcctcccaga gcccttcttc cccaagacgt gtccatggaa     1080

agtagccctg gtttgttctg tcctcatact attggtcctg ctcggtggga tcagccttgg     1140

aatctggaaa gaacatcaag tcaaaaggag agaaattaaa aaatggtcaa aggaacatga     1200

agaaatgctt ctgttgaaga aggggacaaa atctgtactg aagatcagag atgacctcca     1260

ggccgaccta gatcggagga aggcgctgta caaagaagac tggaagaagg ccttgctgta     1320

ccctgactgg aggaaggagc tgttccagga ggctcctgtg aggataaatt atgaaatgcc     1380

tgaccaggac aagacagact caaggacaga agagaacaga ggtgaggaga ctgtcagcag     1440

ctcacaagta gaccacaacc tcatcacact ctcccaggaa ggcttcatgt tgggaagata     1500

ctactgggag gtggatgtca aggacacaga ggagtggaca ctaggagttt atgagctgtg     1560

cactcaggat gcatcactta cagacccctt gaggaaattc agagtcctgg aaaagaatgg     1620

agatggatac agggctcttg acttctgttc ccaaaacatt aattcggaag aacctctgca     1680

actgaagaca cgtccgctga agatcgccat cttcttggat caggaagaca atgacctctc     1740

tttctacaac atgaccgatg agacacacat cttttccttt gcccaggtcc ctttcttggg     1800

atcaccctat ccttacttca cacgtaattc catggggctc tctgcaacag cacagcccta     1860

agtgatgtgc acagggaatt caatgggtgg gtgctgcagc gtgctacccg taaggccctc     1920

ttaggcaggc acagggggcc tctgaccaag aggcctctta acctgagact ccatgagcct     1980

cggggatcag atcctggaca agattctcgg accatctgtg tcgtgcatgg tgttatagtt     2040

attaatagcc ttccttcttt tgacaaaaat gtgtttaatc attcctaaga taaatgaatc     2100

catggctttc tga                                                        2113


<210> 68
<211> 509
<212> PRT
<213> Mus musculus

<400> 68
Met Met Lys Gly Ser Pro Ser Val Pro Pro Ala Gly Cys Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Phe Thr Gly Val Ser Gly Glu Val Ser Trp Phe 
            20                  25                  30          


Ser Val Lys Gly Pro Ala Glu Pro Ile Thr Val Leu Leu Gly Thr Glu 
        35                  40                  45              


Ala Thr Leu Pro Cys Gln Leu Ser Pro Glu Gln Ser Ala Ala Arg Met 
    50                  55                  60                  


His Ile Arg Trp Tyr Arg Ala Gln Pro Thr Pro Ala Val Leu Val Phe 
65                  70                  75                  80  


His Asn Gly Gln Glu Gln Gly Glu Val Gln Met Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Gln Met Val Arg Gln Ala Ile Asp Met Gly Ser Val Ala Leu 
            100                 105                 110         


Gln Ile Gln Gln Val Gln Ala Ser Asp Asp Gly Leu Tyr His Cys Gln 
        115                 120                 125             


Phe Thr Asp Gly Phe Thr Ser Gln Glu Val Ser Met Glu Leu Arg Val 
    130                 135                 140                 


Ile Gly Leu Gly Ser Ala Pro Leu Val His Met Thr Gly Pro Glu Asn 
145                 150                 155                 160 


Asp Gly Ile Arg Val Leu Cys Ser Ser Ser Gly Trp Phe Pro Lys Pro 
                165                 170                 175     


Lys Val Gln Trp Arg Asp Thr Ser Gly Asn Met Leu Leu Ser Ser Ser 
            180                 185                 190         


Glu Leu Gln Thr Gln Asp Arg Glu Gly Leu Phe Gln Val Glu Val Ser 
        195                 200                 205             


Leu Leu Val Thr Asp Arg Ala Ile Gly Asn Val Ile Cys Ser Ile Gln 
    210                 215                 220                 


Asn Pro Met Tyr Asp Gln Glu Lys Ser Lys Ala Ile Leu Leu Pro Glu 
225                 230                 235                 240 


Pro Phe Phe Pro Lys Thr Cys Pro Trp Lys Val Ala Leu Val Cys Ser 
                245                 250                 255     


Val Leu Ile Leu Leu Val Leu Leu Gly Gly Ile Ser Leu Gly Ile Trp 
            260                 265                 270         


Lys Glu His Gln Val Lys Arg Arg Glu Ile Lys Lys Trp Ser Lys Glu 
        275                 280                 285             


His Glu Glu Met Leu Leu Leu Lys Lys Gly Thr Lys Ser Val Leu Lys 
    290                 295                 300                 


Ile Arg Asp Asp Leu Gln Ala Asp Leu Asp Arg Arg Lys Ala Leu Tyr 
305                 310                 315                 320 


Lys Glu Asp Trp Lys Lys Ala Leu Leu Tyr Pro Asp Trp Arg Lys Glu 
                325                 330                 335     


Leu Phe Gln Glu Ala Pro Val Arg Ile Asn Tyr Glu Met Pro Asp Gln 
            340                 345                 350         


Asp Lys Thr Asp Ser Arg Thr Glu Glu Asn Arg Gly Glu Glu Thr Val 
        355                 360                 365             


Ser Ser Ser Gln Val Asp His Asn Leu Ile Thr Leu Ser Gln Glu Gly 
    370                 375                 380                 


Phe Met Leu Gly Arg Tyr Tyr Trp Glu Val Asp Val Lys Asp Thr Glu 
385                 390                 395                 400 


Glu Trp Thr Leu Gly Val Tyr Glu Leu Cys Thr Gln Asp Ala Ser Leu 
                405                 410                 415     


Thr Asp Pro Leu Arg Lys Phe Arg Val Leu Glu Lys Asn Gly Asp Gly 
            420                 425                 430         


Tyr Arg Ala Leu Asp Phe Cys Ser Gln Asn Ile Asn Ser Glu Glu Pro 
        435                 440                 445             


Leu Gln Leu Lys Thr Arg Pro Leu Lys Ile Ala Ile Phe Leu Asp Gln 
    450                 455                 460                 


Glu Asp Asn Asp Leu Ser Phe Tyr Asn Met Thr Asp Glu Thr His Ile 
465                 470                 475                 480 


Phe Ser Phe Ala Gln Val Pro Phe Leu Gly Ser Pro Tyr Pro Tyr Phe 
                485                 490                 495     


Thr Arg Asn Ser Met Gly Leu Ser Ala Thr Ala Gln Pro 
            500                 505                 


<210> 69
<211> 1818
<212> DNA
<213> Homo sapiens

<400> 69
actcattgca ccttcctgcc accccaggca gtgtctgggc cctcagctcc ccctccctcc       60

acctaccccc tcacacccac cactacgacc ccacgggata cccagcccag acggaggaaa      120

caccgagcct agagacatga gagttggagg agcattccac cttctactcg tgtgcctgag      180

cccagcactg ctgtctgctg tgcggatcaa cggggatgga caggaggtcc tgtacctggc      240

agaaggtgat aatgtgaggc tgggctgccc ctacgtcctg gaccctgagg actatggtcc      300

caatgggctg gacatcgagt ggatgcaggt caactcagac cccgcccacc accgagagaa      360

cgtgttcctt agttaccagg acaagaggat caaccatggc agccttcccc atctgcagca      420

gagggtccgc tttgcagcct cagacccaag ccagtacgat gcctccatca acctcatgaa      480

cctgcaggta tctgatacag ccacttatga gtgccgggtg aagaagacca ccatggccac      540

ccggaaggtc attgtcactg tccaagcacg acctgcagtg cccatgtgct ggacagaggg      600

ccacatgaca tatggcaacg atgtggtgct gaagtgctat gccagtgggg gctcccagcc      660

cctctcctac aagtgggcca agatcagtgg gcaccattac ccctatcgag ctgggtctta      720

cacctcccag cacagctacc actcagagct gtcctaccag gagtccttcc acagctccat      780

aaaccaaggc ctgaacaatg gggacctggt gttgaaggat atctccagag cagatgatgg      840

gctgtatcag tgcacagtgg ccaacaacgt gggctacagt gtttgtgtgg tggaggtgaa      900

ggtctcagac tcccggcgta taggcgtgat catcggcatc gtcctgggct ctctgctcgc      960

gctgggctgc ctggccgtag gcatctgggg gctcgtctgc tgctgctgcg ggggctccgg     1020

ggctggcggc gcccgcggtg ccttcggcta cggcaacggc ggcggggtcg gcggaggggc     1080

ctgcggcgac ttggctagtg agatcagaga ggacgccgtg gcgcccgggt gcaaggccag     1140

cgggcgcggc agccgcgtca cccacctcct ggggtacccg acgcagaacg tcagccgctc     1200

cctgcgccgc aagtacgcgc ctcccccctg cggcggcccc gaggacgtgg ccctggcgcc     1260

ctgcaccgcc gccgccgcct gcgaagcggg cccctccccg gtctacgtca aggtcaagag     1320

cgcggagccg gctgactgcg ccgaggggcc ggtgcagtgc aagaacggcc tcttggtgtg     1380

agcgcgcgcg ccgggccggg ctgcgcccca gccaggagga gggcgcgggg ctctctgtct     1440

gcagctgggg acacgtcggg gctggggacg acctcgctcg ccccaggctg ccaggcggct     1500

gggggtgaag gcatttccct aaggaaatgc gtagggaggc agagcctcct ccccaaaagt     1560

gggaaggggc gggcgagggc ggaggaaggc gatcctgagc cttctccgca cccccgggac     1620

cgaaggcttg ggggagaggg agggaggagg aggctgagtg tcctagagcg gctgaggccg     1680

gaggcctggt gtccccagcc taagcagagg gccccggggg ccgggtgggt gggggtctgt     1740

ctggacgaat tgttctgtgt gtgaggtctg agctctgagg cagcagtgtt agcacaataa     1800

agaaacattg agacgtga                                                   1818


<210> 70
<211> 414
<212> PRT
<213> Homo sapiens

<400> 70
Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro 
1               5                   10                  15      


Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu 
            20                  25                  30          


Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu 
        35                  40                  45              


Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln 
    50                  55                  60                  


Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr 
65                  70                  75                  80  


Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg 
                85                  90                  95      


Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn 
            100                 105                 110         


Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val 
        115                 120                 125             


Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala 
    130                 135                 140                 


Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly 
145                 150                 155                 160 


Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu 
                165                 170                 175     


Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala 
            180                 185                 190         


Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln 
        195                 200                 205             


Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu 
    210                 215                 220                 


Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr 
225                 230                 235                 240 


Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val 
                245                 250                 255     


Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser 
            260                 265                 270         


Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys 
        275                 280                 285             


Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly 
    290                 295                 300                 


Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly 
                325                 330                 335     


Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val 
            340                 345                 350         


Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro 
        355                 360                 365             


Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala 
    370                 375                 380                 


Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp 
385                 390                 395                 400 


Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val 
                405                 410                 


<210> 71
<211> 1814
<212> DNA
<213> Mus musculus

<400> 71
actcattgca tcttcctgcc accccgggca gtgtctgggc cctccgctcc ccctccctcc       60

acctgcccct tccacccacc accaccagcc cactggagcc cagctcaggc ggaggaaaga      120

ccaagcctag agacatggga gttcgaggag cactccatct tctacttgtg tgcctgagcc      180

cagcactgtt gtctgctgta aggatcaacg gggatggcca ggaggtcatg tacctggcag      240

aaggtgacaa tgtgaggcta ggctgtccct acctcctgga tcctgaggat ttgggtacca      300

acagtctgga cattgagtgg atgcaagtca actcagagcc ctcacacagg gagaatgttt      360

ttcttactta tcaagacaag aggataggtc atggcaacct cccccatctg cagcagaggg      420

tccgctttgc agcctcagac cccagccagt acgatgcctc catcaacctc atgaacctgc      480

aggtatctga cacagcaacc tatgagtgcc gggtgaagaa gaccaccatg gccaccagga      540

aggtcattgt cactgtccaa gcacgtcctg cggtgcccat gtgttggacg gaaggccaca      600

tgtcaaaggg caacgatgtg gtgctgaagt gctttgccaa cggaggctct cagcccctct      660

cctacaagtg ggccaagatc agtgggcaca gtcaccccta ccgagctggg gcttaccact      720

cacagcacag cttccactct gagctttctt accaagagtc attccacagc accatcaacc      780

aaggcctggg caacggagac ctgctgttga agggcatcaa cgcagacgac gatgggctgt      840

atcagtgcac agtggccaac catgtgggct acagcgtctg tgtggtagag gtgaaagtct      900

cagactccca gcgagtaggc atgatcgttg gagcagtgct gggctctttg ctcatgctgg      960

cctgcctggc actaggcatc tgggggctca tctgctgctg ctgcggaggc ggcggggccg     1020

gtggtgcccg aggtgccttc ggctacgggg tcggcggcgg ggtcggcgga ggggcctgcg     1080

gcgacttggc tagtgagatc agagtggacg ccgaggcgcc cgggtgtaag gccagcgggc     1140

gcggcagccg cgtcacccac ctcctggggt acccgacgca gaacgtcagc cgctccctgc     1200

gccgcaagta cgcgcctccg ccctgcggcg gccccgagga cgtggcccta gtgccccgca     1260

ccgcctccgc ctcctgcgaa gcgggtccct cccccgtcta catcaaggtc aagagcgcgg     1320

agccggccga ctgcgccgac tgtgcccagg tcgagcagcg ctcgtgcaag gacggcctct     1380

tagtgtgagc gcacagcacc gggctgcgcc ccggctggga ggtggttcgg gggctctctg     1440

cccgcagctg gggacaggtt cgggccagca gacctggctc tctcattggc cacctagcgg     1500

tggtaaggaa atttccctct gagaagccaa gccgggcaga ccctcctccc ctgtagtggg     1560

aggagaggcg ggggagacag aaaacagttc agagctctcc ctcacccctg gtttccaggg     1620

agaggaaggg agaggagagc tgtcggtatc ccagaaccgc agaggtacaa cccagatgtc     1680

cccagccaag gcgagggccc cccagccctg ggtaggtgga tgtcagggct gaattgctct     1740

gtgtgtgaga tctgagctcc aaggcaacag tgttagcaca ataaagaaac ttaaagactg     1800

aaaaaaaaaa aaaa                                                       1814


<210> 72
<211> 417
<212> PRT
<213> Mus musculus

<400> 72
Met Gly Val Arg Gly Ala Leu His Leu Leu Leu Val Cys Leu Ser Pro 
1               5                   10                  15      


Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Met 
            20                  25                  30          


Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Leu Leu 
        35                  40                  45              


Asp Pro Glu Asp Leu Gly Thr Asn Ser Leu Asp Ile Glu Trp Met Gln 
    50                  55                  60                  


Val Asn Ser Glu Pro Ser His Arg Glu Asn Val Phe Leu Thr Tyr Gln 
65                  70                  75                  80  


Asp Lys Arg Ile Gly His Gly Asn Leu Pro His Leu Gln Gln Arg Val 
                85                  90                  95      


Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu 
            100                 105                 110         


Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys 
        115                 120                 125             


Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg 
    130                 135                 140                 


Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Ser Lys Gly Asn 
145                 150                 155                 160 


Asp Val Val Leu Lys Cys Phe Ala Asn Gly Gly Ser Gln Pro Leu Ser 
                165                 170                 175     


Tyr Lys Trp Ala Lys Ile Ser Gly His Ser His Pro Tyr Arg Ala Gly 
            180                 185                 190         


Ala Tyr His Ser Gln His Ser Phe His Ser Glu Leu Ser Tyr Gln Glu 
        195                 200                 205             


Ser Phe His Ser Thr Ile Asn Gln Gly Leu Gly Asn Gly Asp Leu Leu 
    210                 215                 220                 


Leu Lys Gly Ile Asn Ala Asp Asp Asp Gly Leu Tyr Gln Cys Thr Val 
225                 230                 235                 240 


Ala Asn His Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser 
                245                 250                 255     


Asp Ser Gln Arg Val Gly Met Ile Val Gly Ala Val Leu Gly Ser Leu 
            260                 265                 270         


Leu Met Leu Ala Cys Leu Ala Leu Gly Ile Trp Gly Leu Ile Cys Cys 
        275                 280                 285             


Cys Cys Gly Gly Gly Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly Tyr 
    290                 295                 300                 


Gly Val Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala Ser 
305                 310                 315                 320 


Glu Ile Arg Val Asp Ala Glu Ala Pro Gly Cys Lys Ala Ser Gly Arg 
                325                 330                 335     


Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val Ser 
            340                 345                 350         


Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro Glu 
        355                 360                 365             


Asp Val Ala Leu Val Pro Arg Thr Ala Ser Ala Ser Cys Glu Ala Gly 
    370                 375                 380                 


Pro Ser Pro Val Tyr Ile Lys Val Lys Ser Ala Glu Pro Ala Asp Cys 
385                 390                 395                 400 


Ala Asp Cys Ala Gln Val Glu Gln Arg Ser Cys Lys Asp Gly Leu Leu 
                405                 410                 415     


Val 
    


<210> 73
<211> 3523
<212> DNA
<213> Homo sapiens

<400> 73
agtcctgggg cagggctggg tggcacggct ggcgagcccg gaacgcctct ggtcacagct       60

cagcgtccgc ggagccgggc ggcgctgcag ctgcacttgg ctcgtctgtg ggtctgacag      120

tcccagctct gcgcggggaa cagcggcccg gcgctgggtg tgggaggacc aggctgcccc      180

aagagcgcgg agactcacgc ccgctcctct cctgttgcga ccgggagccg ggtaggaggc      240

aggcgcgctc cctgcggccc cgggatgact tctcagcgtt cccctctggc gcctttgctg      300

ctcctctctc tgcacggtgt tgcagcatcc ctggaagtgt cagagagccc tgggagtatc      360

caggtggccc ggggtcagcc agcagtcctg ccctgcactt tcactaccag cgctgccctc      420

attaacctca atgtcatttg gatggtcact cctctctcca atgccaacca acctgaacag      480

gtcatcctgt atcagggtgg acagatgttt gatggtgccc cccggttcca cggtagggta      540

ggatttacag gcaccatgcc agctaccaat gtctctatct tcattaataa cactcagtta      600

tcagacactg gcacctacca gtgcctggtc aacaaccttc cagacatagg gggcaggaac      660

attggggtca ccggtctcac agtgttagtt cccccttctg ccccacactg ccaaatccaa      720

ggatcccagg atattggcag cgatgtcatc ctgctctgta gctcagagga aggcattcct      780

cgaccaactt acctttggga gaagttagac aataccctca aactacctcc aacagctact      840

caggaccagg tccagggaac agtcaccatc cggaacatca gtgccctgtc ttcaggtttg      900

taccagtgcg tggcttctaa tgctattgga accagcacct gtcttctgga tctccaggtt      960

atttcacccc agcccaggaa cattggacta atagctggag ccattggcac tggtgcagtt     1020

attatcattt tttgcattgc actaatttta ggggcattct tttactggag aagcaaaaat     1080

aaagaggagg aagaagaaga aattcctaat gaaataagag aggatgatct tccacccaag     1140

tgttcttctg ccaaagcatt tcacactgag atttcctcct cggacaacaa cacactaacc     1200

tcttccaatg cctacaacag tcgatactgg agcaacaatc caaaagttca tagaaacaca     1260

gagtcagtca gccacttcag tgacttgggc caatctttct ctttccactc aggcaatgcc     1320

aacataccat ccatttatgc taatgggacc catctggtcc cgggtcaaca taagactctg     1380

gtagtgacag ccaacagagg gtcatcacca caggtgatgt ccaggagcaa tggctcagtc     1440

agtaggaagc ctcggcctcc acacactcat tcctacacca tcagccacgc aacactggaa     1500

cgaattggtg cagtacctgt catggtacca gcccagagtc gggccgggtc cttggtatag     1560

gacatgagga aatgttgtgt tcagaaatga ataaatggaa tgccctcata caagggggag     1620

ggtggggtgg ggagtgctgg gaaagaaaca cttccttata attatattag taaaatgcac     1680

aaagaagaag gcagtgctgt tacttggcca ctaagatgtg taaaatggac tgaaatgctc     1740

catcatgaag acttgcttcc ccaccaaaga tgtcctggga ttctgctgga tctcaaagat     1800

gtgccaagcc aaggaaaaag atacaagagc agaatagtac ttaaaatcca aactgccgcc     1860

cagatgggct tgttcttcat gcctaactta ataattttta agagattaaa gtgccagatg     1920

gagtttaaat attgaaatta ttttaaaagg taggtgtctt taagaaaata acaagcaacc     1980

ctgtgatatg ttccgtctct cccaattccc tcgttatata gagggcttaa tggtataaat     2040

ggttaatatt ggtcccaaca gggctgactc ttctatcata taatcaaaac tttttacatg     2100

agcaaaattc agtaagaaat gggggaagac aaaggaaacg tctttgagaa gccccttcat     2160

atttatttat ttatctcttc ctgaaccatg aatttcatat gtggaatatt gctatattga     2220

cagattcttg cctgtctgtg ttattctagg atctgttaca ggtccatggc aattactgtt     2280

tattttttcc tggaaaaata tttttttata aaaggctttt tttttttttt aaatacatga     2340

gaggcattgg gctaagaaag aaaagactgt tgtataatac cttgttcaat ggttgtattt     2400

agtgagctca tagaggtcca tcatatcatg accgagctag gttgtgtggg caggaaggta     2460

gggctaaggg gttgtagcct tgctgggcag cctctcagag caaggttgtt cagatctccc     2520

ttgctattac agtaggttac tattaatgag ggcagcacct gatgcctttt gtactgaggt     2580

atgtaacttt ctccttattt gacaagtaga agttaactta cttgtcaggg agggcagacg     2640

tttttttgtt ctgtttcgtt tttcaaaata atgctttttg caaaagaggt aagactgaga     2700

ctaaaggtgt tatcttctgg tgtgctcctg gaagtgtcta ccctacattt gtgtcagctc     2760

agggttgcag tgttgcccag atgcatttta catcactgta aagagattac ttttgtggtt     2820

actacctggc ttggctggcc ttgcggttca ccagattaat ttacaaactc ccccacttta     2880

ttttgtgcta tgtagatctg gccatacttg cattagtgac tgtcttgcct taaccacact     2940

taagcaaccc acaaatttct tctcagattt gtttcctaga ttacttatga tactcatccc     3000

atgtctcaat aagagtgtct tttctttctg gatgtgttct cttactccct cttaccacca     3060

tactttttgc tctcttctcc tgcaagcgta gtcttcacag ggagtggctt cctgacattt     3120

ttttcagtta tgtgaatgaa tggaaaccaa cagctgctgc aaacactgtt tttccaagaa     3180

ggctacactc agaacctaac cattgccaac catttcagta ttgataaaaa gctgaattta     3240

ctttagcatt acttattttt ttttccattt gatggttctt actttgtaaa aatttaaata     3300

aatgaatgtc tatacttttt ataaagaaaa gtgaaaatac catgacactg aaaagatgat     3360

gctatcagat gctgtttaga aagcatttat cttgcatttc tttattcttt ctaattatct     3420

aaaattcaat aaaattttat tcatataaaa taagttgtca ttaattatca atactaacga     3480

gtatgtcatt ttaaaactta gtattctctt taatgttaca aga                       3523


<210> 74
<211> 431
<212> PRT
<213> Homo sapiens

<400> 74
Met Thr Ser Gln Arg Ser Pro Leu Ala Pro Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


His Gly Val Ala Ala Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Ile 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Pro Ala Val Leu Pro Cys Thr Phe Thr Thr 
        35                  40                  45              


Ser Ala Ala Leu Ile Asn Leu Asn Val Ile Trp Met Val Thr Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Pro Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Ile 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro His Cys Gln Ile Gln Gly Ser Gln Asp Ile Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Asn Ile 
225                 230                 235                 240 


Gly Leu Ile Ala Gly Ala Ile Gly Thr Gly Ala Val Ile Ile Ile Phe 
                245                 250                 255     


Cys Ile Ala Leu Ile Leu Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Asp Asn Asn Thr Leu Thr Ser Ser Asn Ala Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Ser Asn Asn Pro Lys Val His Arg Asn Thr Glu Ser Val Ser 
                325                 330                 335     


His Phe Ser Asp Leu Gly Gln Ser Phe Ser Phe His Ser Gly Asn Ala 
            340                 345                 350         


Asn Ile Pro Ser Ile Tyr Ala Asn Gly Thr His Leu Val Pro Gly Gln 
        355                 360                 365             


His Lys Thr Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val 
    370                 375                 380                 


Met Ser Arg Ser Asn Gly Ser Val Ser Arg Lys Pro Arg Pro Pro His 
385                 390                 395                 400 


Thr His Ser Tyr Thr Ile Ser His Ala Thr Leu Glu Arg Ile Gly Ala 
                405                 410                 415     


Val Pro Val Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425                 430     


<210> 75
<211> 3430
<212> DNA
<213> Mus musculus

<400> 75
cggctggtgg tggccgcggc ggccggcgag cccgggacgc ccgagcctgc cccgagcctc       60

ggcggagcgg agtggcctcg gcgctcccgt gtcccgcttg gtcccacgct gcaccccgcc      120

gcccaggagc ccggcggacg gcggctcccc cggcggctcc ggcatgactc ggcggcgctc      180

cgctccggcg tcctggctgc tcgtgtcgct gctcggtgtc gcaacatccc tggaagtgtc      240

cgagagccca ggcagtgtcc aggtggcccg gggccagaca gcagtcctgc cctgcgcctt      300

ctccaccagt gctgccctcc tgaacctcaa tgtcatttgg atggtcattc ccctctccaa      360

tgcaaaccag cccgaacagg tcattcttta tcagggtgga caaatgtttg acggcgccct      420

ccggttccac gggagggtag gatttaccgg caccatgcct gctaccaatg tctcgatctt      480

catcaataac acacagctgt cagatacggg cacgtaccag tgcttggtga ataaccttcc      540

agacagaggg ggcagaaaca tcggggtcac tggcctcaca gtgttagtcc ccccttctgc      600

tccacaatgc caaatccaag gatcccagga cctcggcagt gacgtcatcc ttctgtgtag      660

ttcagaggaa ggcatccctc ggcccacgta cctttgggag aagttagata atacgctcaa      720

gctacctcca acagccactc aggaccaggt ccagggaaca gtcaccatcc ggaatatcag      780

tgccctctct tccggtctgt accagtgtgt ggcttctaat gccatcggga ccagcacctg      840

tctgctggac ctccaggtta tctcacccca gccccggagc gttggagtaa tagccggagc      900

ggttggcacc ggtgctgttc ttatcgtcat ctgccttgca ctaatttcag gggcgttctt      960

ttactggaga agcaaaaaca aagaggagga ggaggaagaa attcctaatg aaatcagaga     1020

ggatgatctt ccccctaaat gctcttctgc caaagccttc cacacggaga tatcctcctc     1080

agaaaataac acgctgacct cttccaatac ctacaacagt cgatactgga acaacaatcc     1140

aaaaccccat agaaacacag agtctttcaa ccacttcagt gacttacgcc agtctttctc     1200

tggcaatgca gttatcccat caatctatgc aaatgggaac catctggttt tgggtccaca     1260

taagactctg gtagttacag ccaacagagg gtcatcacct caggtcttgc ccaggaacaa     1320

tggttcagtc agcaggaagc cttggcctca acacactcat tcctacacag taagccaaat     1380

gaccctggag cgcatcggtg cagtgcctgt catggtgcct gcccagagtc gagcagggtc     1440

cctggtatag gatgactgag gaaaccatgt tcagaagaga ataaatggac cgccttcagg     1500

caagggggga gcactgcctt caggcaaggg gggagcactg ccttcaggca agagggagag     1560

tgggatgggt gagtgctgaa aaataaactt ttgttacgat tccattagca aaaagcacaa     1620

agaggaggcg tgtgtgaagt ggcctggggt tgttccataa tgaagactca agaagactgt     1680

ttccccacca cagatgtcct gagattcagt taaaacgaaa catgctgcat ctccagagat     1740

gtgccaagcc aaggagaatg ctagaagcag agtaaagctt accccccaaa ctgtggtcca     1800

gctggacccc ttctttaatt cttgcctaac ttaattattt tcaggaccct tcaagtgcca     1860

ggtggaattt acataatgaa attatttttt aaaaataggt gtccttaggg agagaaaaca     1920

ggagcaagct catggtctgg cctagtctcc ctctcccact ccttctgatg acactagcaa     1980

tgcattccat ctgacctgac tttatcatag aggcaaaatt gttcagaaca ctggctggag     2040

atggggagaa ataaggaaac ttcttgtgaa caccctacac acacacacac acacacacac     2100

acacacacac acacacacac acacacacac acacacacat ttatttacct cctcctgaac     2160

catgaatcgt attggtgatt ttgctatatt gacagattct catctgttac actctaggat     2220

ctctcacagg tctgtggcaa ttactgttca tgatttcctg aaaaaatatt tttttaaaag     2280

aaaactattt tttttaaata ctagagagac agtggactag gaaagcgaga acttgccgcc     2340

ttgtctagtg actgtattca atgactgaac agaggccccc cccaccatac aagagtttta     2400

ggtgattgag tgggtggaac cagctggagc caggtgggag gggcctttac attgccagca     2460

gggccccaaa gaattgagat tgtgtatggc aaccgttaat gaggacagcg cctgatgcct     2520

tttgtaccga ggaagataat tgcctcttgt ttgacaagta gagtttagta ggttattaca     2580

aaaagggcaa gagttgtttt ggttttgttt ctttcaaaat aatttttttt caaaagaata     2640

acaagggtta ggcaaatggg ggaccttcct gtgtgctctt gggggtctgc tcagcatctg     2700

gaaatttggg tgtgcgattt tccctgaaca cattgcatac cagtgtaaaa agactctgcc     2760

tccccccttt ttggcttttt tactgggctt ggctggcctt gcagtttacc agattcattt     2820

acagactctc tgctctgtat ggcgccgcct gccatgtctg tcttggtgac tatcctgcct     2880

taatcacttt gctttagggc aactcatggt gatctcttcc aagatctgtt tttaaattgt     2940

ttggactact tgagccacaa ctctcagagg acattccttt tttttttttt ttttttttct     3000

cctttcttcc attgctttgt ccctcttccc ctgtgcttcc tgccttcttt ccctgtccca     3060

tgggcacagt cctcacaggg agtggcctcc tctctccagt gatgtaagtg aatggaagcc     3120

atcactggct gcacatacct ttttcaaaag ggacactcgg gaagtcactg ctgtgaccgt     3180

ttcgatgttg ataagaaggt gaatttactg tagtgttacc accttctccc cacttgatgg     3240

ttcttgactt tgtaaaaatt taaataaatg aatgtctata ctttttaagg aaaagagaaa     3300

ataccatgtc acagaaaagg tgaaactatt agatgctgtt tagaaagcat ttatcttgca     3360

tttctttatt ctttctaatt acctaaaatt caataaaagt ttattcatat aaaaaaaaaa     3420

aaaaaaaaaa                                                            3430


<210> 76
<211> 428
<212> PRT
<213> Mus musculus

<400> 76
Met Thr Arg Arg Arg Ser Ala Pro Ala Ser Trp Leu Leu Val Ser Leu 
1               5                   10                  15      


Leu Gly Val Ala Thr Ser Leu Glu Val Ser Glu Ser Pro Gly Ser Val 
            20                  25                  30          


Gln Val Ala Arg Gly Gln Thr Ala Val Leu Pro Cys Ala Phe Ser Thr 
        35                  40                  45              


Ser Ala Ala Leu Leu Asn Leu Asn Val Ile Trp Met Val Ile Pro Leu 
    50                  55                  60                  


Ser Asn Ala Asn Gln Pro Glu Gln Val Ile Leu Tyr Gln Gly Gly Gln 
65                  70                  75                  80  


Met Phe Asp Gly Ala Leu Arg Phe His Gly Arg Val Gly Phe Thr Gly 
                85                  90                  95      


Thr Met Pro Ala Thr Asn Val Ser Ile Phe Ile Asn Asn Thr Gln Leu 
            100                 105                 110         


Ser Asp Thr Gly Thr Tyr Gln Cys Leu Val Asn Asn Leu Pro Asp Arg 
        115                 120                 125             


Gly Gly Arg Asn Ile Gly Val Thr Gly Leu Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Ser Ala Pro Gln Cys Gln Ile Gln Gly Ser Gln Asp Leu Gly Ser Asp 
145                 150                 155                 160 


Val Ile Leu Leu Cys Ser Ser Glu Glu Gly Ile Pro Arg Pro Thr Tyr 
                165                 170                 175     


Leu Trp Glu Lys Leu Asp Asn Thr Leu Lys Leu Pro Pro Thr Ala Thr 
            180                 185                 190         


Gln Asp Gln Val Gln Gly Thr Val Thr Ile Arg Asn Ile Ser Ala Leu 
        195                 200                 205             


Ser Ser Gly Leu Tyr Gln Cys Val Ala Ser Asn Ala Ile Gly Thr Ser 
    210                 215                 220                 


Thr Cys Leu Leu Asp Leu Gln Val Ile Ser Pro Gln Pro Arg Ser Val 
225                 230                 235                 240 


Gly Val Ile Ala Gly Ala Val Gly Thr Gly Ala Val Leu Ile Val Ile 
                245                 250                 255     


Cys Leu Ala Leu Ile Ser Gly Ala Phe Phe Tyr Trp Arg Ser Lys Asn 
            260                 265                 270         


Lys Glu Glu Glu Glu Glu Glu Ile Pro Asn Glu Ile Arg Glu Asp Asp 
        275                 280                 285             


Leu Pro Pro Lys Cys Ser Ser Ala Lys Ala Phe His Thr Glu Ile Ser 
    290                 295                 300                 


Ser Ser Glu Asn Asn Thr Leu Thr Ser Ser Asn Thr Tyr Asn Ser Arg 
305                 310                 315                 320 


Tyr Trp Asn Asn Asn Pro Lys Pro His Arg Asn Thr Glu Ser Phe Asn 
                325                 330                 335     


His Phe Ser Asp Leu Arg Gln Ser Phe Ser Gly Asn Ala Val Ile Pro 
            340                 345                 350         


Ser Ile Tyr Ala Asn Gly Asn His Leu Val Leu Gly Pro His Lys Thr 
        355                 360                 365             


Leu Val Val Thr Ala Asn Arg Gly Ser Ser Pro Gln Val Leu Pro Arg 
    370                 375                 380                 


Asn Asn Gly Ser Val Ser Arg Lys Pro Trp Pro Gln His Thr His Ser 
385                 390                 395                 400 


Tyr Thr Val Ser Gln Met Thr Leu Glu Arg Ile Gly Ala Val Pro Val 
                405                 410                 415     


Met Val Pro Ala Gln Ser Arg Ala Gly Ser Leu Val 
            420                 425             


<210> 77
<211> 1807
<212> DNA
<213> Homo sapiens

<400> 77
acagacgctg gcggccacca gaagtttgag cctctttggt agcaggaggc tggaagaaag       60

gacagaagta gctctggctg tgatggggat cttactgggc ctgctactcc tggggcacct      120

aacagtggac acttatggcc gtcccatcct ggaagtgcca gagagtgtaa caggaccttg      180

gaaaggggat gtgaatcttc cctgcaccta tgaccccctg caaggctaca cccaagtctt      240

ggtgaagtgg ctggtacaac gtggctcaga ccctgtcacc atctttctac gtgactcttc      300

tggagaccat atccagcagg caaagtacca gggccgcctg catgtgagcc acaaggttcc      360

aggagatgta tccctccaat tgagcaccct ggagatggat gaccggagcc actacacgtg      420

tgaagtcacc tggcagactc ctgatggcaa ccaagtcgtg agagataaga ttactgagct      480

ccgtgtccag aaactctctg tctccaagcc cacagtgaca actggcagcg gttatggctt      540

cacggtgccc cagggaatga ggattagcct tcaatgccag gctcggggtt ctcctcccat      600

cagttatatt tggtataagc aacagactaa taaccaggaa cccatcaaag tagcaaccct      660

aagtacctta ctcttcaagc ctgcggtgat agccgactca ggctcctatt tctgcactgc      720

caagggccag gttggctctg agcagcacag cgacattgtg aagtttgtgg tcaaagactc      780

ctcaaagcta ctcaagacca agactgaggc acctacaacc atgacatacc ccttgaaagc      840

aacatctaca gtgaagcagt cctgggactg gaccactgac atggatggct accttggaga      900

gaccagtgct gggccaggaa agagcctgcc tgtctttgcc atcatcctca tcatctcctt      960

gtgctgtatg gtggttttta ccatggccta tatcatgctc tgtcggaaga catcccaaca     1020

agagcatgtc tacgaagcag ccagggcaca tgccagagag gccaacgact ctggagaaac     1080

catgagggtg gccatcttcg caagtggctg ctccagtgat gagccaactt cccagaatct     1140

gggcaacaac tactctgatg agccctgcat aggacaggag taccagatca tcgcccagat     1200

caatggcaac tacgcccgcc tgctggacac agttcctctg gattatgagt ttctggccac     1260

tgagggcaaa agtgtctgtt aaaaatgccc cattaggcca ggatctgctg acataattgc     1320

ctagtcagtc cttgccttct gcatggcctt cttccctgct acctctcttc ctggatagcc     1380

caaagtgtcc gcctaccaac actggagccg ctgggagtca ctggctttgc cctggaattt     1440

gccagatgca tctcaagtaa gccagctgct ggatttggct ctgggccctt ctagtatctc     1500

tgccgggggc ttctggtact cctctctaaa taccagaggg aagatgccca tagcactagg     1560

acttggtcat catgcctaca gacactattc aactttggca tcttgccacc agaagacccg     1620

agggaggctc agctctgcca gctcagagga ccagctatat ccaggatcat ttctctttct     1680

tcagggccag acagctttta attgaaattg ttatttcaca ggccagggtt cagttctgct     1740

cctccactat aagtctaatg ttctgactct ctcctggtgc tcaataaata tctaatcata     1800

acagcaa                                                               1807


<210> 78
<211> 399
<212> PRT
<213> Homo sapiens

<400> 78
Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210> 79
<211> 1434
<212> DNA
<213> Mus musculus

<400> 79
agctaccagc acttccaggt tcttcagcag caagaggatg gaaggatgaa tagaagtagc       60

ttcaaatagg atggagatct catcaggctt gctgttcctg ggccacctaa tagtgctcac      120

ctatggccac cccaccctaa aaacacctga gagtgtgaca gggacctgga aaggagatgt      180

gaagattcag tgcatctatg atcccctgag aggctacagg caagttttgg tgaaatggct      240

ggtaagacac ggctctgact ccgtcaccat cttcctacgt gactccactg gagaccatat      300

ccagcaggca aagtacagag gccgcctgaa agtgagccac aaagttccag gagatgtgtc      360

cctccaaata aataccctgc agatggatga caggaatcac tatacatgtg aggtcacctg      420

gcagactcct gatggaaacc aagtaataag agataagatc attgagctcc gtgttcggaa      480

atataatcca cctagaatca atactgaagc acctacaacc ctgcactcct ctttggaagc      540

aacaactata atgagttcaa cctctgactt gaccactaat gggactggaa aacttgagga      600

gaccattgct ggttcaggga ggaacctgcc aatctttgcc ataatcttca tcatctccct      660

ttgctgcata gtagctgtca ccatacctta tatcttgttc cgctgcagga cattccaaca      720

agagtatgtc tatggagtga gcagggtgtt tgccaggaag acaagcaact ctgaagaaac      780

cacaagggtg actaccatcg caactgatga accagattcc caggctctga ttagtgacta      840

ctctgatgat ccttgcctca gccaggagta ccaaataacc atcagatcaa caatgtctat      900

tcctgcctgc tgaacacagt ttccagaaac taagaagttc ttgctactga agaaaataac      960

atctgctaaa atgcccctac taagtcaagg tctactggcg taattacctg ttacttattt     1020

actacttgcc ttcaacatag ctttctccct ggcttccttt cttcttagac aacctaaagt     1080

atctatctag tctgccaatt ctggggccat tgagaaatcc tgggtttggc taagaatata     1140

ctacatgcac ctcaagaaat ctagcttctg ggcttcaccc agaacaattt tcttcctagg     1200

gccttcacaa ctcttctcca aacagcagag aaattccata gcagtagagg ttctttatca     1260

tgcctccaga cagcgtgagt ctcagtccta caaactcaga caagcacatg ggtctaggat     1320

tactcctctt tctctagggc cagatgactt ttaattgata ttactattgc tacattatga     1380

atctaatgca catgtattct tttgttgtta ataaatgttt aatcatgaca tcaa           1434


<210> 80
<211> 280
<212> PRT
<213> Mus musculus

<400> 80
Met Glu Ile Ser Ser Gly Leu Leu Phe Leu Gly His Leu Ile Val Leu 
1               5                   10                  15      


Thr Tyr Gly His Pro Thr Leu Lys Thr Pro Glu Ser Val Thr Gly Thr 
            20                  25                  30          


Trp Lys Gly Asp Val Lys Ile Gln Cys Ile Tyr Asp Pro Leu Arg Gly 
        35                  40                  45              


Tyr Arg Gln Val Leu Val Lys Trp Leu Val Arg His Gly Ser Asp Ser 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Thr Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Arg Gly Arg Leu Lys Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Ile Asn Thr Leu Gln Met Asp Asp Arg Asn His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Ile Arg Asp 
        115                 120                 125             


Lys Ile Ile Glu Leu Arg Val Arg Lys Tyr Asn Pro Pro Arg Ile Asn 
    130                 135                 140                 


Thr Glu Ala Pro Thr Thr Leu His Ser Ser Leu Glu Ala Thr Thr Ile 
145                 150                 155                 160 


Met Ser Ser Thr Ser Asp Leu Thr Thr Asn Gly Thr Gly Lys Leu Glu 
                165                 170                 175     


Glu Thr Ile Ala Gly Ser Gly Arg Asn Leu Pro Ile Phe Ala Ile Ile 
            180                 185                 190         


Phe Ile Ile Ser Leu Cys Cys Ile Val Ala Val Thr Ile Pro Tyr Ile 
        195                 200                 205             


Leu Phe Arg Cys Arg Thr Phe Gln Gln Glu Tyr Val Tyr Gly Val Ser 
    210                 215                 220                 


Arg Val Phe Ala Arg Lys Thr Ser Asn Ser Glu Glu Thr Thr Arg Val 
225                 230                 235                 240 


Thr Thr Ile Ala Thr Asp Glu Pro Asp Ser Gln Ala Leu Ile Ser Asp 
                245                 250                 255     


Tyr Ser Asp Asp Pro Cys Leu Ser Gln Glu Tyr Gln Ile Thr Ile Arg 
            260                 265                 270         


Ser Thr Met Ser Ile Pro Ala Cys 
        275                 280 


<210> 81
<211> 2237
<212> DNA
<213> Homo sapiens

<400> 81
atttggagag ttaaaactgt gcctaacaga ggtgtcctct gacttttctt ctgcaagctc       60

catgttttca catcttccct ttgactgtgt cctgctgctg ctgctgctac tacttacaag      120

gtcctcagaa gtggaataca gagcggaggt cggtcagaat gcctatctgc cctgcttcta      180

caccccagcc gccccaggga acctcgtgcc cgtctgctgg ggcaaaggag cctgtcctgt      240

gtttgaatgt ggcaacgtgg tgctcaggac tgatgaaagg gatgtgaatt attggacatc      300

cagatactgg ctaaatgggg atttccgcaa aggagatgtg tccctgacca tagagaatgt      360

gactctagca gacagtggga tctactgctg ccggatccaa atcccaggca taatgaatga      420

tgaaaaattt aacctgaagt tggtcatcaa accagccaag gtcacccctg caccgactcg      480

gcagagagac ttcactgcag cctttccaag gatgcttacc accaggggac atggcccagc      540

agagacacag acactgggga gcctccctga tataaatcta acacaaatat ccacattggc      600

caatgagtta cgggactcta gattggccaa tgacttacgg gactctggag caaccatcag      660

aataggcatc tacatcggag cagggatctg tgctgggctg gctctggctc ttatcttcgg      720

cgctttaatt ttcaaatggt attctcatag caaagagaag atacagaatt taagcctcat      780

ctctttggcc aacctccctc cctcaggatt ggcaaatgca gtagcagagg gaattcgctc      840

agaagaaaac atctatacca ttgaagagaa cgtatatgaa gtggaggagc ccaatgagta      900

ttattgctat gtcagcagca ggcagcaacc ctcacaacct ttgggttgtc gctttgcaat      960

gccatagatc caaccacctt atttttgagc ttggtgtttt gtctttttca gaaactatga     1020

gctgtgtcac ctgactggtt ttggaggttc tgtccactgc tatggagcag agttttccca     1080

ttttcagaag ataatgactc acatgggaat tgaactggga cctgcactga acttaaacag     1140

gcatgtcatt gcctctgtat ttaagccaac agagttaccc aacccagaga ctgttaatca     1200

tggatgttag agctcaaacg ggcttttata tacactagga attcttgacg tggggtctct     1260

ggagctccag gaaattcggg cacatcatat gtccatgaaa cttcagataa actagggaaa     1320

actgggtgct gaggtgaaag cataactttt ttggcacaga aagtctaaag gggccactga     1380

ttttcaaaga gatctgtgat ccctttttgt tttttgtttt tgagatggag tcttgctctg     1440

ttgcccaggc tggagtgcaa tggcacaatc tcggctcact gcaagctccg cctcctgggt     1500

tcaagcgatt ctcctgcctc agcctcctga gtggctggga ttacaggcat gcaccaccat     1560

gcccagctaa tttgttgtat ttttagtaga gacagggttt caccatgttg gccagtgtgg     1620

tctcaaactc ctgacctcat gatttgcctg cctcggcctc ccaaagcact gggattacag     1680

gcgtgagcca ccacatccag ccagtgatcc ttaaaagatt aagagatgac tggaccaggt     1740

ctaccttgat cttgaagatt cccttggaat gttgagattt aggcttattt gagcactgcc     1800

tgcccaactg tcagtgccag tgcatagccc ttcttttgtc tcccttatga agactgccct     1860

gcagggctga gatgtggcag gagctcccag ggaaaaacga agtgcatttg attggtgtgt     1920

attggccaag ttttgcttgt tgtgtgcttg aaagaaaata tctctgacca acttctgtat     1980

tcgtggacca aactgaagct atatttttca cagaagaaga agcagtgacg gggacacaaa     2040

ttctgttgcc tggtggaaag aaggcaaagg ccttcagcaa tctatattac cagcgctgga     2100

tcctttgaca gagagtggtc cctaaactta aatttcaaga cggtataggc ttgatctgtc     2160

ttgcttattg ttgccccctg cgcctagcac aattctgaca cacaattgga acttactaaa     2220

aatttttttt tactgtt                                                    2237


<210> 82
<211> 301
<212> PRT
<213> Homo sapiens

<400> 82
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210> 83
<211> 2725
<212> DNA
<213> Mus musculus

<400> 83
accattttaa ccgaggagct aaagctatcc ctacacagag ctgtccttgg atttcccctg       60

ccaagtactc atgttttcag gtcttaccct caactgtgtc ctgctgctgc tgcaactact      120

acttgcaagg tcattggaaa atgcttatgt gtttgaggtt ggtaagaatg cctatctgcc      180

ctgcagttac actctatcta cacctggggc acttgtgcct atgtgctggg gcaagggatt      240

ctgtccttgg tcacagtgta ccaacgagtt gctcagaact gatgaaagaa atgtgacata      300

tcagaaatcc agcagatacc agctaaaggg cgatctcaac aaaggagacg tgtctctgat      360

cataaagaat gtgactctgg atgaccatgg gacctactgc tgcaggatac agttccctgg      420

tcttatgaat gataaaaaat tagaactgaa attagacatc aaagcagcca aggtcactcc      480

agctcagact gcccatgggg actctactac agcttctcca agaaccctaa ccacggagag      540

aaatggttca gagacacaga cactggtgac cctccataat aacaatggaa caaaaatttc      600

cacatgggct gatgaaatta aggactctgg agaaacgatc agaactgcta tccacattgg      660

agtgggagtc tctgctgggt tgaccctggc acttatcatt ggtgtcttaa tccttaaatg      720

gtattcctgt aagaaaaaga agttatcgag tttgagcctt attacactgg ccaacttgcc      780

tccaggaggg ttggcaaatg caggagcagt caggattcgc tctgaggaaa atatctacac      840

catcgaggag aacgtatatg aagtggagaa ttcaaatgag tactactgct acgtcaacag      900

ccagcagcca tcctgaccgc ctctggactg ccacttttaa aggctcgcct tcatttctga      960

ctttggtatt tccctttttg aaaactatgt gatatgtcac ttggcaacct cattggaggt     1020

tctgaccaca gccactgaga aaagagttcc agttttctgg ggataattaa ctcacaaggg     1080

gattcgactg taactcatgc tacattgaaa tgctccattt tatccctgag tttcagggat     1140

cggatctccc actccagaga cttcaatcat gcgtgttgaa gctcactcgt gctttcatac     1200

attaggaatg gttagtgtga tgtctttgag acatagaggt ttgtggtata tctgcaaagc     1260

tcctgaacag gtagggggaa taaagggcta agataggaag gtgaggttct ttgttgatgt     1320

tgaaaatcta aagaagttgg tagcttttct agagatttct gaccttgaaa gattaagaaa     1380

aagccaggtg gcatatgctt aacactatat aacttgggaa ccttaggcag gagggtgata     1440

agttcaaggt cagccagggc tatgctggta agactgtctc aaaatccaaa gacgaaaata     1500

aacatagaga cagcaggagg ctggagatga ggctcggaca gtgaggtgca ttttgtacaa     1560

gcacgaggaa tctatatttg atcgtagacc ccacatgaaa aagctaggcc tggtagagca     1620

tgcttgtaga ctcaagagat ggagaggtaa aggcacaaca gatccccggg gcttgcgtgc     1680

agtcagctta gcctaggtgc tgagttccaa gtccacaaga gtccctgtct caaagtaaga     1740

tggactgagt atctggcgaa tgtccatggg ggttgtcctc tgctctcaga agagacatgc     1800

acatgaacct gcacacacac acacacacac acacacacac acacacacac acacacacac     1860

acacacatga aatgaaggtt ctctctgtgc ctgctacctc tctataacat gtatctctac     1920

aggactctcc tctgcctctg ttaagacatg agtgggagca tggcagagca gtccagtaat     1980

taattccagc actcagaagg ctggagcaga agcgtggaga gttcaggagc actgtgccca     2040

acactgccag actcttctta cagaagaaaa aggttacccg caagcagcct gctgtctgta     2100

aaaggaaacc ctgcgaaagg caaactttga ctgttgtgtg ctcaagggga actgactcag     2160

acaacttctc cattcctgga ggaaactgga gctgtttctg acagaagaac aaccggtgac     2220

tgggacatac gaaggcagag ctcttgcagc aatctatata gtcagcaaaa tattctttgg     2280

gaggacagtc gtcaccaaat tgatttccaa gccggtggac ctcagtttca tctggcttac     2340

agctgcctgc ccagtgccct tgatctgtgc tggctcccat ctataacaga atcaaattaa     2400

atagaccccg agtgaaaata ttaagtgagc agaaaggtag ctttgttcaa agattttttt     2460

gcattgggga gcaactgtgt acatcagagg acatctgtta gtgaggacac caaaacctgt     2520

ggtaccgttt tttcatgtat gaattttgtt gtttaggttg cttctagcta gctgtggagg     2580

tcctggcttt cttaggtggg tatggaaggg agaccatcta acaaaatcca ttagagataa     2640

cagctctcat gcagaaggga aaactaatct caaatgtttt aaagtaataa aactgtactg     2700

gcaaagtact ttgagcatat ttaaa                                           2725


<210> 84
<211> 281
<212> PRT
<213> Mus musculus

<400> 84
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asn Ala Tyr Val Phe Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Ser Thr Pro Gly Ala Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


<210> 85
<211> 1330
<212> DNA
<213> Homo sapiens

<400> 85
agactcctgg gtccggtcaa ccgtcaaaat gtccaaagaa cctctcattc tctggctgat       60

gattgagttt tggtggcttt acctgacacc agtcacttca gagactgttg tgacggaggt      120

tttgggtcac cgggtgactt tgccctgtct gtactcatcc tggtctcaca acagcaacag      180

catgtgctgg gggaaagacc agtgccccta ctccggttgc aaggaggcgc tcatccgcac      240

tgatggaatg agggtgacct caagaaagtc agcaaaatat agacttcagg ggactatccc      300

gagaggtgat gtctccttga ccatcttaaa ccccagtgaa agtgacagcg gtgtgtactg      360

ctgccgcata gaagtgcctg gctggttcaa cgatgtaaag ataaacgtgc gcctgaatct      420

acagagagcc tcaacaacca cgcacagaac agcaaccacc accacacgca gaacaacaac      480

aacaagcccc accaccaccc gacaaatgac aacaacccca gctgcacttc caacaacagt      540

cgtgaccaca cccgatctca caaccggaac accactccag atgacaacca ttgccgtctt      600

cacaacagca aacacgtgcc tttcactaac cccaagcacc cttccggagg aagccacagg      660

tcttctgact cccgagcctt ctaaggaagg gcccatcctc actgcagaat cagaaactgt      720

cctccccagt gattcctgga gtagtgttga gtctacttct gctgacactg tcctgctgac      780

atccaaagag tccaaagttt gggatctccc atcaacatcc cacgtgtcaa tgtggaaaac      840

gagtgattct gtgtcttctc ctcagcctgg agcatctgat acagcagttc ctgagcagaa      900

caaaacaaca aaaacaggac agatggatgg aatacccatg tcaatgaaga atgaaatgcc      960

catctcccaa ctactgatga tcatcgcccc ctccttggga tttgtgctct tcgcattgtt     1020

tgtggcgttt ctcctgagag ggaaactcat ggaaacctat tgttcgcaga aacacacaag     1080

gctagactac attggagata gtaaaaatgt cctcaatgac gtgcagcatg gaagggaaga     1140

cgaagacggc ctttttaccc tctaacaacg cagtagcatg ttagattgag gatgggggca     1200

tgacactcca gtgtcaaaat aagtcttagt agatttcctt gtttcataaa aaagactcac     1260

ttattccatg gatgtcattg atccaggctt gctttagttt catgaatgaa gggtacttta     1320

gagaccacaa                                                            1330


<210> 86
<211> 378
<212> PRT
<213> Homo sapiens

<400> 86
Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210> 87
<211> 2175
<212> DNA
<213> Mus musculus

<400> 87
agatcctatc aaaatgtcca aggggcttct cctcctctgg ctggtgacgg agctctggtg       60

gctttatctg acaccagctg cctcagagga tacaataata gggtttttgg gccagccggt      120

gactttgcct tgtcattacc tctcgtggtc ccagagccgc aacagtatgt gctggggcaa      180

aggttcatgt cccaattcca agtgcaatgc agagcttctc cgtacagatg gaacaagaat      240

catctccagg aagtcaacaa aatatacact tttggggaag gtccagtttg gtgaagtgtc      300

cttgaccatc tcaaacacca atcgaggtga cagtggggtg tactgctgcc gtatagaggt      360

gcctggctgg ttcaatgatg tcaagaagaa tgtgcgcttg gagctgagga gagccacaac      420

aaccaaaaaa ccaacaacaa ccacccggcc aaccaccacc ccttatgtga ccaccaccac      480

cccagagctg cttccaacaa cagtcatgac cacatctgtt ctcccaacca ccacaccacc      540

ccagacacta gccaccactg ccttcagtac agcagtgacc acgtgcccct caacaacacc      600

tggctccttc tcacaagaaa ccacaaaagg gtccgccttc actacagaat cagaaactct      660

gcctgcatcc aatcactctc aaagaagcat gatgaccata tctacagaca tagccgtact      720

caggcccaca ggctctaacc ctgggattct cccatccact tcacagctga cgacacagaa      780

aacaacatta acaacaagtg agtctttgca gaagacaact aaatcacatc agatcaacag      840

cagacagacc atcttgatca ttgcctgctg tgtgggattt gtgctaatgg tgttattgtt      900

tctggcgttt ctccttcgag ggaaagtcac aggagccaac tgtttgcaga gacacaagag      960

gccagacaac actgaagata gtgacagcgt cctcaatgac atgtcacacg ggagggatga     1020

tgaagacggg atcttcactc tctgactcac catctttatt taggattaag gatagggaat     1080

ggcacttgaa ttgtcaaaat aagtttgggg acattgtaat ttccgtttaa agtctcactc     1140

tgtttactga tgctgtgggt cctgtctggt tgtatcttcc cacatgaagg tgctttagag     1200

acacattttc cctgcctcgt gccttagtcc tctttgttgt tttgtggcta ggtgactttt     1260

cacactgggc ttgaacactg tcagtgatgg tgaaatcctt gccacagctt tgggagtctc     1320

ttgcagtctc ccagcagtag agggagttag aaatatccag aggggaaaaa aaaatctctc     1380

ttttcagaca gtatctgctt tattggtggt agctgaactt catttataca gagctccttt     1440

aacctgtctg tcttcttctt ggtatctaag ctgccttttg tttttgtttt tgtttttgtt     1500

tttatgatat taacttcttt tcacattcaa gtttctttaa agttgactat agtgccttct     1560

gaactcttgc agagagtttg gattttggaa gctgccaggt acccatcaca gcaggggtgc     1620

cagtgacaag gatggtgtac aaatgaaaca ctgaagctat ccaaataaat tcctctaagt     1680

gtaattcatt ttactgcagc acaggaagaa caaatttgtc ttacaacttt aataattagt     1740

accattatga accctaggag agaaataaga gcaaatacct gttgaataaa tgaatgtaag     1800

aaaatgtgtg tctgagcaag aatactctgt ctggctacta tgggaagcta gctagatctg     1860

aaagacattc tcagactatc ctcatgttca aggcattaaa ggaataagcc tccagcccct     1920

aaccttagga gaattctgca gtcaagtgag gagtttttaa aacaggaatc tctaggttcc     1980

agtcctctag ctattctttt atgcttagtc caggtaatga gttgaacatc caagtatttt     2040

ttaaggaccc aaagaaatgc aaccagagct attaccagaa ttttggagtg gtcctcctag     2100

agttgccgca tgttgctggg aaaattgggg tcttagagtt cttagtctac ttaataaaag     2160

aattttaaaa aatgg                                                      2175


<210> 88
<211> 343
<212> PRT
<213> Mus musculus

<400> 88
Met Ser Lys Gly Leu Leu Leu Leu Trp Leu Val Thr Glu Leu Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Ala Ala Ser Glu Asp Thr Ile Ile Gly Phe Leu 
            20                  25                  30          


Gly Gln Pro Val Thr Leu Pro Cys His Tyr Leu Ser Trp Ser Gln Ser 
        35                  40                  45              


Arg Asn Ser Met Cys Trp Gly Lys Gly Ser Cys Pro Asn Ser Lys Cys 
    50                  55                  60                  


Asn Ala Glu Leu Leu Arg Thr Asp Gly Thr Arg Ile Ile Ser Arg Lys 
65                  70                  75                  80  


Ser Thr Lys Tyr Thr Leu Leu Gly Lys Val Gln Phe Gly Glu Val Ser 
                85                  90                  95      


Leu Thr Ile Ser Asn Thr Asn Arg Gly Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Lys Asn Val Arg 
        115                 120                 125             


Leu Glu Leu Arg Arg Ala Thr Thr Thr Lys Lys Pro Thr Thr Thr Thr 
    130                 135                 140                 


Arg Pro Thr Thr Thr Pro Tyr Val Thr Thr Thr Thr Pro Glu Leu Leu 
145                 150                 155                 160 


Pro Thr Thr Val Met Thr Thr Ser Val Leu Pro Thr Thr Thr Pro Pro 
                165                 170                 175     


Gln Thr Leu Ala Thr Thr Ala Phe Ser Thr Ala Val Thr Thr Cys Pro 
            180                 185                 190         


Ser Thr Thr Pro Gly Ser Phe Ser Gln Glu Thr Thr Lys Gly Ser Ala 
        195                 200                 205             


Phe Thr Thr Glu Ser Glu Thr Leu Pro Ala Ser Asn His Ser Gln Arg 
    210                 215                 220                 


Ser Met Met Thr Ile Ser Thr Asp Ile Ala Val Leu Arg Pro Thr Gly 
225                 230                 235                 240 


Ser Asn Pro Gly Ile Leu Pro Ser Thr Ser Gln Leu Thr Thr Gln Lys 
                245                 250                 255     


Thr Thr Leu Thr Thr Ser Glu Ser Leu Gln Lys Thr Thr Lys Ser His 
            260                 265                 270         


Gln Ile Asn Ser Arg Gln Thr Ile Leu Ile Ile Ala Cys Cys Val Gly 
        275                 280                 285             


Phe Val Leu Met Val Leu Leu Phe Leu Ala Phe Leu Leu Arg Gly Lys 
    290                 295                 300                 


Val Thr Gly Ala Asn Cys Leu Gln Arg His Lys Arg Pro Asp Asn Thr 
305                 310                 315                 320 


Glu Asp Ser Asp Ser Val Leu Asn Asp Met Ser His Gly Arg Asp Asp 
                325                 330                 335     


Glu Asp Gly Ile Phe Thr Leu 
            340             


<210> 89
<211> 3491
<212> DNA
<213> Homo sapiens

<400> 89
agcacagaga gtggaaaaca gcagaggtga cagagcagcc gtgctcgaag cgttcctgga       60

gcccaagctc tcctccacag gtgaagacag ggccagcagg agacaccatg gggcacctct      120

cagccccact tcacagagtg cgtgtaccct ggcaggggct tctgctcaca gcctcacttc      180

taaccttctg gaacccgccc accactgccc agctcactac tgaatccatg ccattcaatg      240

ttgcagaggg gaaggaggtt cttctccttg tccacaatct gccccagcaa ctttttggct      300

acagctggta caaaggggaa agagtggatg gcaaccgtca aattgtagga tatgcaatag      360

gaactcaaca agctacccca gggcccgcaa acagcggtcg agagacaata taccccaatg      420

catccctgct gatccagaac gtcacccaga atgacacagg attctacacc ctacaagtca      480

taaagtcaga tcttgtgaat gaagaagcaa ctggacagtt ccatgtatac ccggagctgc      540

ccaagccctc catctccagc aacaactcca accctgtgga ggacaaggat gctgtggcct      600

tcacctgtga acctgagact caggacacaa cctacctgtg gtggataaac aatcagagcc      660

tcccggtcag tcccaggctg cagctgtcca atggcaacag gaccctcact ctactcagtg      720

tcacaaggaa tgacacagga ccctatgagt gtgaaataca gaacccagtg agtgcgaacc      780

gcagtgaccc agtcaccttg aatgtcacct atggcccgga cacccccacc atttcccctt      840

cagacaccta ttaccgtcca ggggcaaacc tcagcctctc ctgctatgca gcctctaacc      900

cacctgcaca gtactcctgg cttatcaatg gaacattcca gcaaagcaca caagagctct      960

ttatccctaa catcactgtg aataatagtg gatcctatac ctgccacgcc aataactcag     1020

tcactggctg caacaggacc acagtcaaga cgatcatagt cactgagcta agtccagtag     1080

tagcaaagcc ccaaatcaaa gccagcaaga ccacagtcac aggagataag gactctgtga     1140

acctgacctg ctccacaaat gacactggaa tctccatccg ttggttcttc aaaaaccaga     1200

gtctcccgtc ctcggagagg atgaagctgt cccagggcaa caccaccctc agcataaacc     1260

ctgtcaagag ggaggatgct gggacgtatt ggtgtgaggt cttcaaccca atcagtaaga     1320

accaaagcga ccccatcatg ctgaacgtaa actataatgc tctaccacaa gaaaatggcc     1380

tctcacctgg ggccattgct ggcattgtga ttggagtagt ggccctggtt gctctgatag     1440

cagtagccct ggcatgtttt ctgcatttcg ggaagaccgg cagggcaagc gaccagcgtg     1500

atctcacaga gcacaaaccc tcagtctcca accacactca ggaccactcc aatgacccac     1560

ctaacaagat gaatgaagtt acttattcta ccctgaactt tgaagcccag caacccacac     1620

aaccaacttc agcctcccca tccctaacag ccacagaaat aatttattca gaagtaaaaa     1680

agcagtaatg aaacctgtcc tgctcactgc agtgctgatg tatttcaagt ctctcaccct     1740

catcactagg agattccttt cccctgtagg ggtagagggg tggggacaga aacaactttc     1800

tcctactctt ccttcctaat aggcatctcc aggctgcctg gtcactgccc ctctctcagt     1860

gtcaatagat gaaagtacat tgggagtctg taggaaaccc aaccttcttg tcattgaaat     1920

ttggcaaagc tgactttggg aaagagggac cagaacttcc cctcccttcc ccttttccca     1980

acctggactt gttttaaact tgcctgttca gagcactcat tccttcccac ccccagtcct     2040

gtcctatcac tctaattcgg atttgccata gccttgaggt tatgtccttt tccattaagt     2100

acatgtgcca ggaaacaaga gagagagaaa gtaaaggcag taatgccttc tcctatttct     2160

ccaaagcctt gtgtgaactc accaaacaca agaaaatcaa atatataacc aatagtgaaa     2220

tgccacacct ttgtccactg tcagggttgt ctacctgtag gatcagggtc taagcacctt     2280

ggtgcttagc tagaatacca cctaatcctt ctggcaagcc tgtcttcaga gaacccacta     2340

gaagcaacta ggaaaatcac ttgccaaaat ccaaggcaat tcctgatgga aaatgcaaaa     2400

gcacatatat gttttaatat ctttatgggc tctgttcaag gcagtgctga gagggagggg     2460

ttatagcttc aggagggaac cagcttctga taaacacaat ctgctaggaa cttgggaaag     2520

gaatcagaga gctgcccttc agcgattatt taaattattg ttaaagaata cacaatttgg     2580

ggtattggga tttttctcct tttctctgag acattccacc attttaattt ttgtaactgc     2640

ttatttatgt gaaaagggtt atttttactt agcttagcta tgtcagccaa tccgattgcc     2700

ttaggtgaaa gaaaccaccg aaatccctca ggtcccttgg tcaggagcct ctcaagattt     2760

tttttgtcag aggctccaaa tagaaaataa gaaaaggttt tcttcattca tggctagagc     2820

tagatttaac tcagtttcta ggcacctcag accaatcatc aactaccatt ctattccatg     2880

tttgcacctg tgcattttct gtttgccccc attcactttg tcaggaaacc ttggcctctg     2940

ctaaggtgta tttggtcctt gagaagtggg agcaccctac agggacacta tcactcatgc     3000

tggtggcatt gtttacagct agaaagctgc actggtgcta atgccccttg gggaaatggg     3060

gctgtgagga ggaggattat aacttaggcc tagcctcttt taacagcctc tgaaatttat     3120

cttttcttct atggggtcta taaatgtatc ttataataaa aaggaaggac aggaggaaga     3180

caggcaaatg tacttctcac ccagtcttct acacagatgg aatctctttg gggctaagag     3240

aaaggtttta ttctatattg cttacctgat ctcatgttag gcctaagagg ctttctccag     3300

gaggattagc ttggagttct ctatactcag gtacctcttt cagggttttc taaccctgac     3360

acggactgtg catactttcc ctcatccatg ctgtgctgtg ttatttaatt tttcctggct     3420

aagatcatgt ctgaattatg tatgaaaatt attctatgtt tttataataa aaataatata     3480

tcagacatcg a                                                          3491


<210> 90
<211> 526
<212> PRT
<213> Homo sapiens

<400> 90
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210> 91
<211> 3736
<212> DNA
<213> Mus musculus

<400> 91
aaagctcctt taagaaaagc agggcagata tcagggcagc ctggcttagc agtagtgttg       60

gagaagaagc tagcaggcag gcagcagaga catggagctg gcctcagcac atctccacaa      120

agggcaggtt ccctggggag gactactgct cacagcctca cttttagcct cctggagccc      180

tgccaccact gctgaagtca ccattgaggc tgtgccgccc caggttgctg aagacaacaa      240

tgttcttcta cttgttcaca atctgcccct ggcgcttgga gcctttgcct ggtacaaggg      300

aaacactacg gctatagaca aagaaattgc acgatttgta ccaaatagta atatgaattt      360

cacggggcaa gcatacagcg gcagagagat aatatacagc aatggatccc tgctcttcca      420

aatgatcacc atgaaggata tgggagtcta cacactagat atgacagatg aaaactatcg      480

tcgtactcag gcgactgtgc gatttcatgt acaccccata ttattaaagc ccaacatcac      540

aagcaacaac tccaatcccg tggagggtga cgactccgta tcattaacct gtgactctta      600

cactgaccct gataatataa actacctgtg gagcagaaat ggtgaaagcc tttcagaagg      660

tgacaggctg aagctgtctg agggcaacag gactctcact ttactcaatg tcacgaggaa      720

tgacacagga ccctatgtgt gtgaaacccg gaatccagtg agtgtcaacc gaagtgaccc      780

attcagcctg aacattatct atggtccgga caccccgatt atatccccct cagatattta      840

tttgcatcca gggtcaaacc tcaacctctc ctgccatgca gcctctaacc cacctgcaca      900

gtacttttgg cttatcaatg agaagcccca tgcatcctcc caagagctct ttatccccaa      960

catcactact aataatagcg gaacctatac ctgcttcgtc aataactctg tcactggcct     1020

cagtaggacc acagtcaaga acattacagt ccttgagcca gtgactcagc ccttcctcca     1080

agtcaccaac accacagtca aagaactaga ctctgtgacc ctgacctgct tgtcgaatga     1140

cattggagcc aacatccagt ggctcttcaa tagccagagt cttcagctca cagagagaat     1200

gacactctcc cagaacaaca gcatcctcag aatagaccct attaagaggg aagatgccgg     1260

cgagtatcag tgtgaaatct cgaatccagt cagcgtcagg aggagcaact caatcaagct     1320

ggacataata tttgacccaa cacaaggagg cctctcagat ggcgccattg ctggcatcgt     1380

gattggagtt gtggctgggg tggctctaat agcagggctg gcatatttcc tctattccag     1440

gaagtctggc gggggaagtg accagcgaga tctcacagag cacaaaccct cagcctccaa     1500

ccacaatctg gctccttctg acaactctcc taacaaggtg gatgacgtcg catacactgt     1560

cctgaacttc aattcccagc aacccaaccg gccaacttca gccccttctt ctccaagagc     1620

cacagaaaca gtttattcag aagtaaaaaa gaagtgagca taatctgtcc gtctgtcctg     1680

ctggctgcac cagtgatgca ttcccggatt ctgttcctca ctggagggtc tcagcacaca     1740

cacacacgta cacatgcgcg cgcgcacaca cacacacaca cacacacaca cacacttaca     1800

cacacactca tgcattcact ctattgactc cttcagtgtc tatagaagaa aaggtggatc     1860

ctggagccta cagaaaactc aacccttcta ggctttcaaa tttggctgag agtgaggtat     1920

caaaatttct caccctttca ctttcctgac ccagattgtt gaaaattgac ctattcagag     1980

caccttcatt cccctcccaa ctccaagtcc tgccctatca gagtctgact tgaatttcca     2040

taaaccttgg aggtcaccta agtgcttacg ccaaacaaaa caaaacaaaa caaaacaaaa     2100

caaaacaaaa caaaacaaaa caaaccagaa gcaggaaatg gccagtccca tatctttaaa     2160

ggctgattgg aagccaccat acatgagaag atcaaacctc catgggcaat ctacacaccc     2220

gacaactgtc atgcttaccc atctgggaca ttcgagtctc tgaaccttgt gccctcacgc     2280

ctgagccctt ctctgagcct ttctccagaa aatccactca cagcaactag agaggctctt     2340

tgtcagcaac tccaagcaaa ctgctaggca ggattcagaa gaaaagacag catctctaac     2400

atccaccagg aaggtgccca gaaaagcaga gctggtgact ttggactgac agacatctgg     2460

agtgtgaaaa agcagcacag agctaacctt cggagagtgt tgaaattatt tgaaaagaag     2520

ccatatttgg aggtattgga gttttcctct ttctgagaca atccactatt tgaaaattgt     2580

agctactgaa ttgcctctca gtatgcgagc tgatcacttt gccttagggc cactagattt     2640

ctgtctccct tagcccctca agcccttttg atcatgagtt ccaaaccaaa aataaataaa     2700

tgaacagtga ggcagtccct tgcagtacca ctgtcatggg tcaggctaag cctcctgctt     2760

ttctgaatta gtcaagaaaa gccttggttt ccctttttcc atctctttat cttgtctttc     2820

agatactggc cagagcctgg acactcttcc tctgagatct ccagcttctc tgccttcttg     2880

tgtttctttt aaactctaac aaaaactgtt ctcaccttca aaaaataaaa taataacaag     2940

ctttccacat ccccaccaaa gagggaccca gctaggtttc tggaaaccca gcaccagcct     3000

ccagctgccc ttctgcagtg tttctgcctc tgtttccctt tcgttttgac ttttttcctt     3060

cttttgagac agagttccag catggagcct gtgcaggttt caatcccaca gtaacacctt     3120

ctgcagcacc ccacctgctc agactgcagc cctggccacc aggcctggct acctggacat     3180

tctgtctgcc ctgcactctc aggaaacctt ggcctctgct actgtctgtt tggctcattc     3240

aaagtgtgtc cttaaaggaa tgcagtcacc catgccagag gcagtgttta cagcctggaa     3300

tgctctgcac ttccagtgga ccagtgctcc accggaagtg ggctgttagc agggtcctct     3360

cacctggccc tggcctttct gtagccttga atcctgcctt ccccaccagg gcaccaggga     3420

tgagtgcagc agcaggagga gaggcaaaca gtcacctcag gaaccttctg agctaaggca     3480

caccctctgt gcctgtcaag caaaggttgt attggatatc aagtgtttgg tctcacgcca     3540

agccaacagg ctttggagag aattaattag ttctcctact cagggatttc tttcagtcct     3600

aacacagcct gtgtatattt tgcttcaccc acgcaatgct ggattattta attttgcccg     3660

gcttaagaca aatctgagtt acttgtaaat ttgctctatg ttcataataa aaatgtatta     3720

tatatcactg atagca                                                     3736


<210> 92
<211> 521
<212> PRT
<213> Mus musculus

<400> 92
Met Glu Leu Ala Ser Ala His Leu His Lys Gly Gln Val Pro Trp Gly 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Ala Ser Trp Ser Pro Ala Thr 
            20                  25                  30          


Thr Ala Glu Val Thr Ile Glu Ala Val Pro Pro Gln Val Ala Glu Asp 
        35                  40                  45              


Asn Asn Val Leu Leu Leu Val His Asn Leu Pro Leu Ala Leu Gly Ala 
    50                  55                  60                  


Phe Ala Trp Tyr Lys Gly Asn Thr Thr Ala Ile Asp Lys Glu Ile Ala 
65                  70                  75                  80  


Arg Phe Val Pro Asn Ser Asn Met Asn Phe Thr Gly Gln Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Ser Asn Gly Ser Leu Leu Phe Gln Met Ile 
            100                 105                 110         


Thr Met Lys Asp Met Gly Val Tyr Thr Leu Asp Met Thr Asp Glu Asn 
        115                 120                 125             


Tyr Arg Arg Thr Gln Ala Thr Val Arg Phe His Val His Pro Ile Leu 
    130                 135                 140                 


Leu Lys Pro Asn Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Gly Asp 
145                 150                 155                 160 


Asp Ser Val Ser Leu Thr Cys Asp Ser Tyr Thr Asp Pro Asp Asn Ile 
                165                 170                 175     


Asn Tyr Leu Trp Ser Arg Asn Gly Glu Ser Leu Ser Glu Gly Asp Arg 
            180                 185                 190         


Leu Lys Leu Ser Glu Gly Asn Arg Thr Leu Thr Leu Leu Asn Val Thr 
        195                 200                 205             


Arg Asn Asp Thr Gly Pro Tyr Val Cys Glu Thr Arg Asn Pro Val Ser 
    210                 215                 220                 


Val Asn Arg Ser Asp Pro Phe Ser Leu Asn Ile Ile Tyr Gly Pro Asp 
225                 230                 235                 240 


Thr Pro Ile Ile Ser Pro Ser Asp Ile Tyr Leu His Pro Gly Ser Asn 
                245                 250                 255     


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Phe 
            260                 265                 270         


Trp Leu Ile Asn Glu Lys Pro His Ala Ser Ser Gln Glu Leu Phe Ile 
        275                 280                 285             


Pro Asn Ile Thr Thr Asn Asn Ser Gly Thr Tyr Thr Cys Phe Val Asn 
    290                 295                 300                 


Asn Ser Val Thr Gly Leu Ser Arg Thr Thr Val Lys Asn Ile Thr Val 
305                 310                 315                 320 


Leu Glu Pro Val Thr Gln Pro Phe Leu Gln Val Thr Asn Thr Thr Val 
                325                 330                 335     


Lys Glu Leu Asp Ser Val Thr Leu Thr Cys Leu Ser Asn Asp Ile Gly 
            340                 345                 350         


Ala Asn Ile Gln Trp Leu Phe Asn Ser Gln Ser Leu Gln Leu Thr Glu 
        355                 360                 365             


Arg Met Thr Leu Ser Gln Asn Asn Ser Ile Leu Arg Ile Asp Pro Ile 
    370                 375                 380                 


Lys Arg Glu Asp Ala Gly Glu Tyr Gln Cys Glu Ile Ser Asn Pro Val 
385                 390                 395                 400 


Ser Val Arg Arg Ser Asn Ser Ile Lys Leu Asp Ile Ile Phe Asp Pro 
                405                 410                 415     


Thr Gln Gly Gly Leu Ser Asp Gly Ala Ile Ala Gly Ile Val Ile Gly 
            420                 425                 430         


Val Val Ala Gly Val Ala Leu Ile Ala Gly Leu Ala Tyr Phe Leu Tyr 
        435                 440                 445             


Ser Arg Lys Ser Gly Gly Gly Ser Asp Gln Arg Asp Leu Thr Glu His 
    450                 455                 460                 


Lys Pro Ser Ala Ser Asn His Asn Leu Ala Pro Ser Asp Asn Ser Pro 
465                 470                 475                 480 


Asn Lys Val Asp Asp Val Ala Tyr Thr Val Leu Asn Phe Asn Ser Gln 
                485                 490                 495     


Gln Pro Asn Arg Pro Thr Ser Ala Pro Ser Ser Pro Arg Ala Thr Glu 
            500                 505                 510         


Thr Val Tyr Ser Glu Val Lys Lys Lys 
        515                 520     


<210> 93
<211> 3388
<212> DNA
<213> Homo sapiens

<400> 93
attcctcacg atgacccgac agtctctgct ttctttttcc tttcttccag aaggagattt       60

aaccatagta gaaagaatgg agaactatta actgcctttc ttctgtgggc tgtgattttc      120

agaggggaat gctaagaggt gattttcaat gttgggactc aaaggtgaag acactgaagg      180

acagaatttt tggcagagga aagatcttct tcggtcacca tacttgagtt agctctaggg      240

aagtggaggt ttccatttgg aattctatag cttcttccag gtcatagtgt ctgcccccca      300

ccttccagta tctcctgata tgcagcatga atgaaaatgg caagtttcct ggccttcctt      360

ctgctcaact ttcgtgtctg cctccttttg cttcagctgc tcatgcctca ctcagctcag      420

ttttctgtgc ttggaccctc tgggcccatc ctggccatgg tgggtgaaga cgctgatctg      480

ccctgtcacc tgttcccgac catgagtgca gagaccatgg agctgaagtg ggtgagttcc      540

agcctaaggc aggtggtgaa cgtgtatgca gatggaaagg aagtggaaga caggcagagt      600

gcaccgtatc gagggagaac ttcgattctg cgggatggca tcactgcagg gaaggctgct      660

ctccgaatac acaacgtcac agcctctgac agtggaaagt acttgtgtta tttccaagat      720

ggtgacttct atgaaaaagc cctggtggag ctgaaggttg cagcactggg ttctgatctt      780

cacgttgatg tgaagggtta caaggatgga gggatccatc tggagtgcag gtccactggc      840

tggtaccccc aaccccaaat acagtggagc aacaacaagg gagagaacat cccgactgtg      900

gaagcacctg tggttgcaga cggagtgggc ctgtatgcag tagcagcatc tgtgatcatg      960

agaggcagct ctggggaggg tgtatcctgt accatcagaa gttccctcct cggcctggaa     1020

aagacagcca gcatttccat cgcagacccc ttcttcagga gcgcccagag gtggatcgcc     1080

gccctggcag ggaccctgcc tgtcttgctg ctgcttcttg ggggagccgg ttacttcctg     1140

tggcaacagc aggaggaaaa aaagactcag ttcagaaaga aaaagagaga gcaagagttg     1200

agagaaatgg catggagcac aatgaagcaa gaacaaagca caagagtgaa gctcctggag     1260

gaactcagat ggagaagtat ccagtatgca tctcggggag agagacattc agcctataat     1320

gaatggaaaa aggccctctt caagcctgcg gatgtgattc tggatccaaa aacagcaaac     1380

cccatcctcc ttgtttctga ggaccagagg agtgtgcagc gtgccaagga gccccaggat     1440

ctgccagaca accctgagag atttaattgg cattattgtg ttctcggctg tgagagcttc     1500

atatcaggga gacattactg ggaggtggag gtaggggaca ggaaagagtg gcatataggg     1560

gtgtgcagta agaatgtgca gagaaaaggc tgggtcaaaa tgacacctga gaatggattc     1620

tggactatgg ggctgactga tgggaataag tatcggactc taactgagcc cagaaccaac     1680

ctgaaacttc ctaagccccc taagaaagtg ggggtcttcc tggactatga gactggagat     1740

atctcattct acaatgctgt ggatggatcg catattcata ctttcctgga cgtctccttc     1800

tctgaggctc tatatcctgt tttcagaatt ttgaccttgg agcccacggc cctgactatt     1860

tgtccagcgt gaaaagaaga agagagttcc tccaattctg accgagtgct gatcattccc     1920

tagagacacc agtaaccccg ggcttagcta acgaaagtgg ggagcctcag gctgaagtaa     1980

cttttctctg cttctccctg cccagctcag agctgagggc ctccccctcc acagcaacca     2040

atcacaacca taaagctaca agcacgcact gaagcacttt actgatactc attcaattat     2100

tcatatgaca gttgtttgag tttggtacca tcttattttc cccttataca gataaggaaa     2160

ctggggtgca gaaaagtgaa ttgactacaa agtagacatg actagttaac aacacagctg     2220

ggatctaaac agcaataact aacattaatg gagaacttaa aatgctctga gtgctgtgtt     2280

atgagctttg gtggatgtca ctcctttaat cctcgcaaca ccctgtcggg tagtctcatt     2340

tagcaagtat ggaagttgag gcagggcaac attaagcaac ttacataact catgcagtaa     2400

tttctgcagt tgggagatgt tcagcttcag tccccggccc tatggccgtt cttttccacc     2460

ctgtttcttc ccccatagga agaacccacc tgtagccctg aggttctttt cccaggatgg     2520

ctccaggata aggatcactg taggtggttg tggagttgac acccctgttg actccttccc     2580

agctgattgt cagagcctta gacccagcac gccttggatt agctctgcag agtgtcttgg     2640

ttgagagaat aacctcaccg tacccacatg acacgtgatt tggaaagaga ctagaggcca     2700

cacttgataa atcatgggga acagatgtgt tccacccaac aaatgtgata agtgatcatg     2760

cagccagagc cagccttcct tcaatcaagg tttccaggca gagcaaatac cctagagatt     2820

ctctgtgata taggaaattt ggatgaaggg agctagaaga aatacaggga tttttttttt     2880

tttttaagat ggagtcttac tctgttgcta ggctggagtg cagtggtgcg atctcagctc     2940

cctgcaacct ccacctcctg ggttcaaaca attctcctgc ctcagcctcc cgagtactgg     3000

gaatataggt gcacgccacc acacccaaca aatttttgta cttttagtac agatgagggt     3060

tcactatgtt ggccaggatg gtctcgatct cttgacctca tgatccaccc acctcggtct     3120

cccaaagtgc tgggattaca ggcttgagcc accgggtgac cggcttacag ggatattttt     3180

aatcccgtta tggactctgt ctccaggaga ggggtctatc cacccctgct cattggtgga     3240

tgttaaacca atattccttt caactgctgc ctgctaggga aaaactactc ctcattatca     3300

tcattattat tgctctccac tgtatcccct ctacctggca tgtgcttgtc aagttctagt     3360

tgttcaataa atttgttaat aatgctga                                        3388


<210> 94
<211> 513
<212> PRT
<213> Homo sapiens

<400> 94
Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr 
            420                 425                 430         


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg 
        435                 440                 445             


Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210> 95
<211> 3776
<212> DNA
<213> Homo sapiens

<400> 95
gactcttact gtttctcatg gtgagaagac aatatttgct ttctcttttt cctttcttcc       60

ggatgagagg ctaagccata atagaaagaa tggagaatta ttgattgacc gtctttattc      120

tgtgggctct gattctccaa tgggaatacc aagggatggt tttccatact ggaacccaaa      180

ggtaaagaca ctcaaggaca gacatttttg gcagagcata gatgaaaatg gcaagttccc      240

tggctttcct tctgctcaac tttcatgtct ccctcctctt ggtccagctg ctcactcctt      300

gctcagctca gttttctgtg cttggaccct ctgggcccat cctggccatg gtgggtgaag      360

acgctgatct gccctgtcac ctgttcccga ccatgagtgc agagaccatg gagctgaagt      420

gggtaagttc cagcctaagg caggtggtga acgtgtatgc agatggaaag gaagtggaag      480

acaggcagag tgcaccgtat cgagggagaa cttcgattct gcgggatggc atcactgcag      540

ggaaggctgc tctccgaata cacaacgtca cagcctctga cagtggaaag tacttgtgtt      600

atttccaaga tggtgacttc tatgaaaaag ccctggtgga gctgaaggtt gcagcactgg      660

gttctaatct tcacgtcgaa gtgaagggtt atgaggatgg agggatccat ctggagtgca      720

ggtccaccgg ctggtacccc caaccccaaa tacagtggag caacgccaag ggagagaaca      780

tcccagctgt ggaagcacct gtggttgcag atggagtggg cctatatgaa gtagcagcat      840

ctgtgatcat gagaggcggc tccggggagg gtgtatcctg catcatcaga aattccctcc      900

tcggcctgga aaagacagcc agcatttcca tcgcagaccc cttcttcagg agcgcccagc      960

cctggatcgc agccctggca gggaccctgc ctatcttgct gctgcttctc gccggagcca     1020

gttacttctt gtggagacaa cagaaggaaa taactgctct gtccagtgag atagaaagtg     1080

agcaagagat gaaagaaatg ggatatgctg caacagagcg ggaaataagc ctaagagaga     1140

gcctccagga ggaactcaag aggaaaaaaa tccagtactt gactcgtgga gaggagtctt     1200

cgtccgatac caataagtca gcctgatgct ctaatggaaa aatggccctc ttcaagcctg     1260

gtgaggaaat gcttcagatg aggctccacc ttgttaaata aattggatgt atggaaaaat     1320

agactgcaga aaaggggaac tcatttagct cacgagtggt cgagtgaaga ttgaaaatta     1380

acctctgagg gccagcacag cagctcatgc ctgtaatcct agcactttgg aaggctgagg     1440

agggcggatc acaaggtcag gagatcaaga ccatcctggc taacacggtg aaaccccgtc     1500

tctactaaaa atacaaaaaa taaaaaatta gccgggcatg gtgacgggca cctgtagtcc     1560

cagctactcg ggaggctgag gcaggagaat ggcatgaacc cggaaggcag agcttgcagt     1620

gagccgagat cacgccactg cactccagcc tgggagacag agcgagactc tgtctcaaga     1680

aaaaaaaaaa aaaaaaaaaa gaaaagaaaa ttaacctctg agtataaagc atcagtgggc     1740

agaatcaatg tggggaggga aacaacaaaa atgtagaaag aggatccttg ttgcttcttg     1800

gggccgcatc agggtattgg gttaggcaga tactgacctt actttcattt cccctctggt     1860

cactagaccc ctggggcttt caccaatgac attgatgaga gaatcacatt cagggcaggc     1920

tagggacacg gggttctgga aggacctcct cagcatggcc caagccttgc atgctgtggc     1980

tcttaaatcc aggaaaaatg gctgacccca tggacacctc ctcaaactct ctgcagcaga     2040

tgtaattctg tatccagaca tggcaaatgc catcctcctt gtttctgagg accagaggag     2100

tgtacagcgt gctgaggagc cccatgacct accagacaac cctgagagat ttgaatggcg     2160

ttactgtgtg cttggctgtg aaagcttcat gtcagagaga cactactggg aggtggaagt     2220

gggggacaga aaagagtggc atattggggt atgtagtaag aacgtggaga ggaaaaaagt     2280

ttgggtcaaa atgacaccgg agaacggata ctggactatg ggcctgactg atgggaataa     2340

gtatcgggct ctcactgagc ccagaaccaa cctgaaactt cctgagcctc ctaggaaagt     2400

gggggtcatc ctggactatg agactggaca tatctcgttc tacaatgcca cggatggatc     2460

tcatatctac acatttctgc acgcctcttc ctctgagcct ctgtatcctg tattcagaat     2520

tttgaccttg gagcccactg ccctgaccgt ttgcccaata ccaaaagtag agagttcccc     2580

cgatcccgac ctagtgcctg atcattccct ggagatacca ctgaccccag gcttagctaa     2640

tgaaagtggg gagcctcagg ctgaagtaac atctctgctt ctccctgccc agcctggagc     2700

taagggtctc accctccaca acagccagtc agaaccataa agctacaggc acacactgaa     2760

gcactttact gatattcatt caattattcc ataggacagt tgtttgagtt tggtgccacc     2820

ttattggccc ctttatacag ataaggaaac tggggtgtag aaaagtgtat tgactttaca     2880

aagcagacag gaatagtgaa caacagagct gggatctgaa caacaatgac taacattaat     2940

ggagaattta aaacgttctg agtgctgtgt tatgagcttt ggtgggtgtc actcctttaa     3000

tcctcacaac accctgtcag gtagtctcat ttggcaagta tggaagcaga ggcagggcaa     3060

cattaagtag cttacataac tcacacggta atttgtgcag ttgggagatg ttcagcttca     3120

gtccctggcc aattgcccgt tcttttccag cctgattttt cctgcatggg aagagcccac     3180

atgtagccct gaggttccct tcccaggaca gctccaggat cgagatcact gtgagtggtt     3240

gtggagttaa gacccctatg gactccttcc cagctgatta tcagagcctt agacccagca     3300

ctccttggat tggctctgca gagtgtcttg gttgagagaa taacgttgca gttcccacag     3360

ggcatgtgac tttgaaagag actagaggcc acactcagtt aataatgggg cacagatgtg     3420

ttcccaccca acaaatgtga taagtgatcg tgcagccaga gccagccttc cttcagtcaa     3480

ggtttccagg cagagcaaat accctagaga ttctctgtaa tattggtaat ttggatgaag     3540

gaagctagaa gaattacagg gatgttttta atcccactat ggactcagtc tcctggaaaa     3600

ggatctgtcc actcctggtc attggtggat gttaaaccca tattcctttc aactgctgcc     3660

tgctagggaa aactgctcct cattatcatc actattattg ctcaccactg tatcccctct     3720

actgggcaag tgcttgtcaa gttctagttg ttcaataaat ttgttaataa tgctga         3776


<210> 96
<211> 334
<212> PRT
<213> Homo sapiens

<400> 96
Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210> 97
<211> 2890
<212> DNA
<213> Homo sapiens

<400> 97
agatttcgtt tcctgcatct ccaaacatgg cgacctagga gaaggggaag aacaattttt       60

tctcctcttt tgggaaggtt tgtgtctagt agtgcctgtg cccctgggca gattggagag      120

aagagggacg actggagaat cgtcgagaac cagcggagaa aagaaaaagc aacgtttaat      180

tctagaaggc ctcctgtccc tgcctgctct gggtgctcat ggaatcagct gctgccctgc      240

acttctcccg gccagcctcc ctcctcctcc tcctcctcag cctgtgtgca ctggtctcag      300

cccagtttat tgtcgtgggg cccactgatc ccatcttggc cacggttgga gaaaacacta      360

cgttacgctg ccatctgtca cccgagaaaa atgctgagga catggaggtg cggtggttcc      420

ggtctcagtt ctcccccgca gtgtttgtgt ataaaggtgg cagagagaga acagaggagc      480

agatggagga gtaccgagga agaaccacct ttgtgagcaa agacatcagc aggggcagcg      540

tggccctggt catacacaac atcacagccc aggaaaacgg cacctaccgc tgttacttcc      600

aagaaggcag gtcctacgat gaggccatcc tgcacctcgt agtggcagga ctaggctcta      660

agcccctcat ttcaatgagg ggccatgaag acgggggcat ccggctggag tgcatatcta      720

gagggtggta cccaaagccc ctcacagtgt ggagggaccc ctacggtggg gttgcgcctg      780

ccctgaaaga ggtctccatg cctgatgcag acggcctctt catggtcacc acggctgtga      840

tcatcagaga caagtctgtg aggaacatgt cctgctctat caacaacacc ctgctcggcc      900

agaagaaaga aagtgtcatt tttattccag aatcctttat gcccagtgtg tctccctgtg      960

cagtggccct gcctatcatt gtggttattc tgatgatacc cattgccgta tgcatctatt     1020

ggatcaacaa actccaaaag gaaaaaaaga ttctgtcagg ggaaaaggag tttgaacggg     1080

aaacaagaga aattgctcta aaggaactgg agaaagaacg tgtgcaaaaa gaggaagaac     1140

ttcaagtaaa agagaaactt caagaagaat tgcgatggag aagaacattc ttacatgctg     1200

ttgatgtggt cctggatcca gacaccgctc atcccgatct cttcctgtca gaggaccgga     1260

gaagtgtgag aaggtgcccc ttcaggcacc taggggagag cgtgcctgac aacccagaga     1320

gattcgacag tcagccttgt gtcctaggcc gggagagctt cgcttcaggg aaacattact     1380

gggaggtgga ggtggaaaac gtgattgagt ggactgtggg ggtctgtaga gacagtgttg     1440

agaggaaagg ggaggtcctg ctgattcctc agaatggctt ctggaccttg gagatgcata     1500

aagggcaata ccgggccgtg tcctcccctg ataggattct ccctttgaag gagtcccttt     1560

gccgggtggg cgtcttcctg gactatgaag ctggagatgt ctccttctac aacatgaggg     1620

acagatcgca catctacaca tgtccccgtt cagccttttc cgtgcctgtg aggcccttct     1680

tcaggttggg gtgtgaggac agccccatct tcatctgccc tgcactcaca ggagccaatg     1740

gggtcacggt gcctgaagag ggcctgacac ttcacagagt ggggacccac cagagcctat     1800

agaatcaatt ccttggtctc acagccatgt agacaagccc tggtcatctc agcagccacc     1860

gcacaacacc cctggtggaa gacacgccct cctcccctct ggtcacacaa gagaacatct     1920

tccagctgcc tctttcacac ccactacaga cctcagcccc agttttctcc tcctcactag     1980

gctgtgtttt tagtagttcc tttgcttgta actatgggat gggatccagg catagggaac     2040

tagttgttac acagctccca gccaagaaga aagtgtgaga agttgatggg cagcaaacct     2100

gctgtttaac atcagggtga ccacattaag cccagtattc cagttggcac cagaagatat     2160

ggacttggaa tgaggcctac agggttcacc aggatgtaag aggagagagg aatccacagg     2220

accaccagag aggagaggga accagatatg cagatcagag atagaggaag tggaaccaga     2280

gagctgggag ggaccaaggt tgtaagggtg gctaagtccc accataacag ctaaggggac     2340

ctgggagatg atggctcatt tccacccagc cccaggattt ccagagcgca catccacagg     2400

cctggacctg ggatgaagat gaatgaagaa catggatgca cgtggatgta gtttggctca     2460

ggtgtccctg cagttggcaa ggagtcagta ctcagtccct gagtgtggct gaaatttgag     2520

gtcctggctg agccaaggag taatggacca gatctacctc agtattcaag ttcagtgggg     2580

acaccagtgg cttcaaactt cctggtttca tgatatcttg agacgcctta caaatgatgg     2640

aggattccaa agagtttttg tttatttggg ttaatatttg ttggtattta tggcatttga     2700

gattgaaact aagaaatgtt ttaatttatt acctttacaa catttattta cattacatac     2760

atacatttac aacatttatt aatttatatt aaaatagcat gaataagcca attataggtt     2820

aatataagta gaatgtttgt gaaaaataag tatggtatcc aaagcaaaat aaattttatt     2880

gtgaagtgtg                                                            2890


<210> 98
<211> 527
<212> PRT
<213> Homo sapiens

<400> 98
Met Glu Ser Ala Ala Ala Leu His Phe Ser Arg Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala Gln Phe Ile Val 
            20                  25                  30          


Val Gly Pro Thr Asp Pro Ile Leu Ala Thr Val Gly Glu Asn Thr Thr 
        35                  40                  45              


Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu Asp Met Glu Val 
    50                  55                  60                  


Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe Val Tyr Lys Gly 
65                  70                  75                  80  


Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr Arg Gly Arg Thr 
                85                  90                  95      


Thr Phe Val Ser Lys Asp Ile Ser Arg Gly Ser Val Ala Leu Val Ile 
            100                 105                 110         


His Asn Ile Thr Ala Gln Glu Asn Gly Thr Tyr Arg Cys Tyr Phe Gln 
        115                 120                 125             


Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu His Leu Val Val Ala Gly 
    130                 135                 140                 


Leu Gly Ser Lys Pro Leu Ile Ser Met Arg Gly His Glu Asp Gly Gly 
145                 150                 155                 160 


Ile Arg Leu Glu Cys Ile Ser Arg Gly Trp Tyr Pro Lys Pro Leu Thr 
                165                 170                 175     


Val Trp Arg Asp Pro Tyr Gly Gly Val Ala Pro Ala Leu Lys Glu Val 
            180                 185                 190         


Ser Met Pro Asp Ala Asp Gly Leu Phe Met Val Thr Thr Ala Val Ile 
        195                 200                 205             


Ile Arg Asp Lys Ser Val Arg Asn Met Ser Cys Ser Ile Asn Asn Thr 
    210                 215                 220                 


Leu Leu Gly Gln Lys Lys Glu Ser Val Ile Phe Ile Pro Glu Ser Phe 
225                 230                 235                 240 


Met Pro Ser Val Ser Pro Cys Ala Val Ala Leu Pro Ile Ile Val Val 
                245                 250                 255     


Ile Leu Met Ile Pro Ile Ala Val Cys Ile Tyr Trp Ile Asn Lys Leu 
            260                 265                 270         


Gln Lys Glu Lys Lys Ile Leu Ser Gly Glu Lys Glu Phe Glu Arg Glu 
        275                 280                 285             


Thr Arg Glu Ile Ala Leu Lys Glu Leu Glu Lys Glu Arg Val Gln Lys 
    290                 295                 300                 


Glu Glu Glu Leu Gln Val Lys Glu Lys Leu Gln Glu Glu Leu Arg Trp 
305                 310                 315                 320 


Arg Arg Thr Phe Leu His Ala Val Asp Val Val Leu Asp Pro Asp Thr 
                325                 330                 335     


Ala His Pro Asp Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg 
            340                 345                 350         


Cys Pro Phe Arg His Leu Gly Glu Ser Val Pro Asp Asn Pro Glu Arg 
        355                 360                 365             


Phe Asp Ser Gln Pro Cys Val Leu Gly Arg Glu Ser Phe Ala Ser Gly 
    370                 375                 380                 


Lys His Tyr Trp Glu Val Glu Val Glu Asn Val Ile Glu Trp Thr Val 
385                 390                 395                 400 


Gly Val Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile 
                405                 410                 415     


Pro Gln Asn Gly Phe Trp Thr Leu Glu Met His Lys Gly Gln Tyr Arg 
            420                 425                 430         


Ala Val Ser Ser Pro Asp Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys 
        435                 440                 445             


Arg Val Gly Val Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr 
    450                 455                 460                 


Asn Met Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe 
465                 470                 475                 480 


Ser Val Pro Val Arg Pro Phe Phe Arg Leu Gly Cys Glu Asp Ser Pro 
                485                 490                 495     


Ile Phe Ile Cys Pro Ala Leu Thr Gly Ala Asn Gly Val Thr Val Pro 
            500                 505                 510         


Glu Glu Gly Leu Thr Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520                 525         


<210> 99
<211> 2017
<212> DNA
<213> Homo sapiens

<400> 99
agaacagcgc agtttgccct ccgctcacgc agagcctctc cgtggcttcc gcaccttgag       60

cattaggcca gttctcctct tctctctaat ccatccgtca cctctcctgt catccgtttc      120

catgccgtga ggtccattca cagaacacat ccatggctct catgctcagt ttggttctga      180

gtctcctcaa gctgggatca gggcagtggc aggtgtttgg gccagacaag cctgtccagg      240

ccttggtggg ggaggacgca gcattctcct gtttcctgtc tcctaagacc aatgcagagg      300

ccatggaagt gcggttcttc aggggccagt tctctagcgt ggtccacctc tacagggacg      360

ggaaggacca gccatttatg cagatgccac agtatcaagg caggacaaaa ctggtgaagg      420

attctattgc ggaggggcgc atctctctga ggctggaaaa cattactgtg ttggatgctg      480

gcctctatgg gtgcaggatt agttcccagt cttactacca gaaggccatc tgggagctac      540

aggtgtcagc actgggctca gttcctctca tttccatcac gggatatgtt gatagagaca      600

tccagctact ctgtcagtcc tcgggctggt tcccccggcc cacagcgaag tggaaaggtc      660

cacaaggaca ggatttgtcc acagactcca ggacaaacag agacatgcat ggcctgtttg      720

atgtggagat ctctctgacc gtccaagaga acgccgggag catatcctgt tccatgcggc      780

atgctcatct gagccgagag gtggaatcca gggtacagat aggagatacc tttttcgagc      840

ctatatcgtg gcacctggct accaaagtac tgggaatact ctgctgtggc ctattttttg      900

gcattgttgg actgaagatt ttcttctcca aattccagtg gaaaatccag gcggaactgg      960

actggagaag aaagcacgga caggcagaat tgagagacgc ccggaaacac gcagtggagg     1020

tgactctgga tccagagacg gctcacccga agctctgcgt ttctgatctg aaaactgtaa     1080

cccatagaaa agctccccag gaggtgcctc actctgagaa gagatttaca aggaagagtg     1140

tggtggcttc tcagagtttc caagcaggga aacattactg ggaggtggac ggaggacaca     1200

ataaaaggtg gcgcgtggga gtgtgccggg atgatgtgga caggaggaag gagtacgtga     1260

ctttgtctcc cgatcatggg tactgggtcc tcagactgaa tggagaacat ttgtatttca     1320

cattaaatcc ccgttttatc agcgtcttcc ccaggacccc acctacaaaa ataggggtct     1380

tcctggacta tgagtgtggg accatctcct tcttcaacat aaatgaccag tcccttattt     1440

ataccctgac atgtcggttt gaaggcttat tgaggcccta cattgagtat ccgtcctata     1500

atgagcaaaa tggaactccc atagtcatct gcccagtcac ccaggaatca gagaaagagg     1560

cctcttggca aagggcctct gcaatcccag agacaagcaa cagtgagtcc tcctcacagg     1620

caaccacgcc cttcctcccc aggggtgaaa tgtaggatga atcacatccc acattcttct     1680

ttagggatat taaggtctct ctcccagatc caaagtcccg cagcagccgg ccaaggtggc     1740

ttccagatga agggggactg gcctgtccac atgggagtca ggtgtcatgg ctgccctgag     1800

ctgggaggga agaaggctga cattacattt agtttgctct cactccatct ggctaagtga     1860

tcttgaaata ccacctctca ggtgaagaac cgtcaggaat tcccatctca caggctgtgg     1920

tgtagattaa gtagacaagg aatgtgaata atgcttagat cttattgatg acagagtgta     1980

tcctaatggt ttgttcatta tattacactt tcagtaa                              2017


<210> 100
<211> 500
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg 
            340                 345                 350         


Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr 
        355                 360                 365             


Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro 
385                 390                 395                 400 


Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser 
        435                 440                 445             


Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln 
    450                 455                 460                 


Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu 
465                 470                 475                 480 


Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro 
                485                 490                 495     


Arg Gly Glu Met 
            500 


<210> 101
<211> 3583
<212> DNA
<213> Homo sapiens

<400> 101
gggacttttt ggacacccag agaacaggtc ccagataccg agtccgcaac tccaaacatc       60

gcgattaata ggaggcctct ggtctctgcc tgccctgggt gctcatggaa ccagctgctg      120

ctctgcactt ctccctgcca gcctccctcc tcctcctcct gctcctcctc cttctcagcc      180

tgtgtgcact ggtctcagcc cagtttactg tcgtggggcc agctaatccc atcctggcca      240

tggtgggaga aaacactaca ttacgctgcc atctgtcacc cgagaaaaat gctgaggaca      300

tggaggtgcg gtggttccgg tctcagttct cccccgcagt gtttgtgtat aagggtggga      360

gagagagaac agaggagcag atggaggagt accggggaag aatcaccttt gtgagcaaag      420

acatcaacag gggcagcgtg gccctggtca tacataacgt cacagcccag gagaatggga      480

tctaccgctg ttacttccaa gaaggcaggt cctacgatga ggccatccta cgcctcgtgg      540

tggcaggcct tgggtctaag cccctcattg aaatcaaggc ccaagaggat gggagcatct      600

ggctggagtg catatctgga gggtggtacc cagagcccct cacagtgtgg agggacccct      660

acggtgaggt tgtgcccgcc ctgaaggagg tttccatcgc tgatgctgac ggcctcttca      720

tggtcaccac agctgtgatc atcagagaca agtatgtgag gaatgtgtcc tgctctgtca      780

acaacaccct gctcggccag gagaaggaaa ctgtcatttt tattccagaa tcctttatgc      840

ccagcgcatc tccctggatg gtggccctag ctgtcatcct gaccgcatct ccctggatgg      900

tgtccatgac tgtcatcctg gctgttttca tcatcttcat ggctgtcagc atctgttgca      960

tcaagaaact tcaaagggaa aaaaagattc tgtcagggga aaagaaagtt gaacaagagg     1020

aaaaagaaat tgcacagcaa cttcaagaag aattgcgatg gagaagaaca ttcttacatg     1080

ctgctgatgt ggtcctggat ccagacaccg ctcatcccga gctcttcctg tcagaggacc     1140

ggagaagtgt gaggcggggc ccctacaggc agagagtgcc tgacaaccca gagagattcg     1200

acagtcagcc ttgtgtcctg ggatgggaga gcttcgcctc agggaaacat tactgggagg     1260

tggaggtgga aaacgtgatg gtgtggactg tgggggtctg cagacacagt gttgagagga     1320

aaggggaggt cctgctgatt cctcagaatg gcttctggac cctggagatg tttggaaacc     1380

aataccgggc cctgtcctcc cctgagagga ttctcccttt gaaggagtcc ctttgccggg     1440

tgggcgtctt cctggactat gaagctggag atgtctcctt ctacaacatg agggacagat     1500

cgcacatcta cacatgtccc cgttcagcct ttactgtgcc tgtgaggccc ttcttcaggt     1560

tagggtctga tgacagcccc atcttcatct gccctgcact cacaggagcc agtggggtca     1620

tggtgcctga agagggcctg aaacttcaca gagtggggac ccaccagagc ctatagaatc     1680

aattccttgg actcacagcc atgcagataa gccctggcca tctcagcagc caccgcacaa     1740

cccccctaat gaaagacacg ccctcctccc ctctggtcac gtaagagaac atcttccagc     1800

tgcctttttc acacccactc cagccctctg ccccagtttt ctcctcctca ctagtctgtg     1860

gctttagtag ttcctttgct tgtaattatg ggatgggatc caggcatagg gaactagttg     1920

tttcatagct cccagtcaaa aagaaagtga gagaagctgt tgggcagcga acctactgtt     1980

taaaatcagg ataaccacat taagcccaat atgccagttg gcaccagatg ctgtggactt     2040

ggaatgaggc caacagggtt caccaggatg agagaggaga gaggaatcca caggaccacc     2100

agaagggaga gggaaccaga tatgcagatc agagatagag gaagtggaac cagagagctg     2160

ggagggacca aggttgtaag gatggctaag tcccaccata agagctaaag ggtcctggga     2220

gatgatggct catttccacc caaccccagg atttccacag cacacaccca caggcctgga     2280

cctgggatga agatgaatga agaacatgga ctcatgtgga tgtggtttgg ctcagatgtc     2340

cctgcaataa acaaggggtc agtacttagt ccctgagtgt ggttgaggtt tgaggtcctg     2400

gtcgagcagg gcagtactgg accaggtcta cgtcagcatt caggttcaat ggggacacca     2460

gtggcttcaa acttcctgat ctaattatgt ttttagacac ttagaagtta ttgaggactt     2520

taaagagctt ttgtttattt gggttaatat ttatgacatt tgacattgaa acaaaaattt     2580

aaaatgttat cttttaattt atgttaaaat agcattaata aatcagttat aggttaatgt     2640

agataggatg ttttgtgaaa aagcaatcta ttgtgtccaa ataaaaaaac aaaaagtgtg     2700

acactggtta actttttcca gatctcatgt ctggcttaat aagagatatt tgtattatca     2760

tatctgcctt tgtattaaac ctattggtat atcataggtc atgttagctc aaaaaaactt     2820

tactgcacac tactgagaga atgagatgaa aaacgattaa tgtttcatta ttattattgt     2880

gaaaatatta ttaacactgg ggactcctta agagtacatc agagttctct ctaggaatcc     2940

caaaaccaca ttttgaaact agaatagtgg atcctggaag ttaatccatg tgctggttaa     3000

ttttagatgt caacctgact ggattaagga atacctagac agctggtaca acattatttc     3060

tgggtgtgtc tgtgagtgtg tttccagaag agattggcaa gtgagtcagt gggaaattct     3120

ctccttctgt tggctgggtg cccaatacaa caaaaaggca gaggaaaggc aaattcttct     3180

ctcctctgga gctgagacac tcttcttctt ctgcccttgg acatcagaac tcctggctct     3240

ccggcctttg aacttcagga cttgtaccag gaggccctgg gttctcaggc ctttggcttt     3300

ggactgagag ttacacaatc agcttccctg gttctgaggc tttcagactt aaactgagcc     3360

atgctaccag catcccaggg tctccagcct acagatgagc tgttgtgcga tttcttagcc     3420

tccataatca catgagccaa tctccttaat aaatgcctgc tcatagatct gtatctacat     3480

ctatatctgt atgtgcatct atatctatgc ctatatctat atctatatca tattgatttt     3540

gtctctctgg agaaccctga ctaataaaat gaggcatcta aaa                       3583


<210> 102
<211> 523
<212> PRT
<213> Homo sapiens

<400> 102
Met Glu Pro Ala Ala Ala Leu His Phe Ser Leu Pro Ala Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ser Leu Cys Ala Leu Val Ser Ala 
            20                  25                  30          


Gln Phe Thr Val Val Gly Pro Ala Asn Pro Ile Leu Ala Met Val Gly 
        35                  40                  45              


Glu Asn Thr Thr Leu Arg Cys His Leu Ser Pro Glu Lys Asn Ala Glu 
    50                  55                  60                  


Asp Met Glu Val Arg Trp Phe Arg Ser Gln Phe Ser Pro Ala Val Phe 
65                  70                  75                  80  


Val Tyr Lys Gly Gly Arg Glu Arg Thr Glu Glu Gln Met Glu Glu Tyr 
                85                  90                  95      


Arg Gly Arg Ile Thr Phe Val Ser Lys Asp Ile Asn Arg Gly Ser Val 
            100                 105                 110         


Ala Leu Val Ile His Asn Val Thr Ala Gln Glu Asn Gly Ile Tyr Arg 
        115                 120                 125             


Cys Tyr Phe Gln Glu Gly Arg Ser Tyr Asp Glu Ala Ile Leu Arg Leu 
    130                 135                 140                 


Val Val Ala Gly Leu Gly Ser Lys Pro Leu Ile Glu Ile Lys Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Ser Ile Trp Leu Glu Cys Ile Ser Gly Gly Trp Tyr Pro 
                165                 170                 175     


Glu Pro Leu Thr Val Trp Arg Asp Pro Tyr Gly Glu Val Val Pro Ala 
            180                 185                 190         


Leu Lys Glu Val Ser Ile Ala Asp Ala Asp Gly Leu Phe Met Val Thr 
        195                 200                 205             


Thr Ala Val Ile Ile Arg Asp Lys Tyr Val Arg Asn Val Ser Cys Ser 
    210                 215                 220                 


Val Asn Asn Thr Leu Leu Gly Gln Glu Lys Glu Thr Val Ile Phe Ile 
225                 230                 235                 240 


Pro Glu Ser Phe Met Pro Ser Ala Ser Pro Trp Met Val Ala Leu Ala 
                245                 250                 255     


Val Ile Leu Thr Ala Ser Pro Trp Met Val Ser Met Thr Val Ile Leu 
            260                 265                 270         


Ala Val Phe Ile Ile Phe Met Ala Val Ser Ile Cys Cys Ile Lys Lys 
        275                 280                 285             


Leu Gln Arg Glu Lys Lys Ile Leu Ser Gly Glu Lys Lys Val Glu Gln 
    290                 295                 300                 


Glu Glu Lys Glu Ile Ala Gln Gln Leu Gln Glu Glu Leu Arg Trp Arg 
305                 310                 315                 320 


Arg Thr Phe Leu His Ala Ala Asp Val Val Leu Asp Pro Asp Thr Ala 
                325                 330                 335     


His Pro Glu Leu Phe Leu Ser Glu Asp Arg Arg Ser Val Arg Arg Gly 
            340                 345                 350         


Pro Tyr Arg Gln Arg Val Pro Asp Asn Pro Glu Arg Phe Asp Ser Gln 
        355                 360                 365             


Pro Cys Val Leu Gly Trp Glu Ser Phe Ala Ser Gly Lys His Tyr Trp 
    370                 375                 380                 


Glu Val Glu Val Glu Asn Val Met Val Trp Thr Val Gly Val Cys Arg 
385                 390                 395                 400 


His Ser Val Glu Arg Lys Gly Glu Val Leu Leu Ile Pro Gln Asn Gly 
                405                 410                 415     


Phe Trp Thr Leu Glu Met Phe Gly Asn Gln Tyr Arg Ala Leu Ser Ser 
            420                 425                 430         


Pro Glu Arg Ile Leu Pro Leu Lys Glu Ser Leu Cys Arg Val Gly Val 
        435                 440                 445             


Phe Leu Asp Tyr Glu Ala Gly Asp Val Ser Phe Tyr Asn Met Arg Asp 
    450                 455                 460                 


Arg Ser His Ile Tyr Thr Cys Pro Arg Ser Ala Phe Thr Val Pro Val 
465                 470                 475                 480 


Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Ile Phe Ile Cys 
                485                 490                 495     


Pro Ala Leu Thr Gly Ala Ser Gly Val Met Val Pro Glu Glu Gly Leu 
            500                 505                 510         


Lys Leu His Arg Val Gly Thr His Gln Ser Leu 
        515                 520             


<210> 103
<211> 2983
<212> DNA
<213> Mus musculus

<400> 103
gaaattgtga gacttgcacg cggaatgggt cctccgaggt ctgctgtcgc gagtcccagc       60

actttgcaag taatggagaa cagaaaattc tttcctctct actgtagcag tttgttctct      120

ggtggcgact gtgctcagcg acaagttgga gagtagagaa aaggcaagat aatcagcatt      180

tgagggtcag agaagaaaag aaaacgcagt taattctaga aggttttctg tccacacgtg      240

acctaggtga ctctgtcctg aagacctatg gagcctacaa cttccctgcg ttcttgcccg      300

atagcctccc ttctcttctt cttggtcctc agcctgtttg tgctggtctc agcccagttt      360

actgtcatag gaccagctga gcccatcctg gccatggtag gagagaatac cacactacac      420

tgccacctgt caccagagag aaatgccgaa gagatggagg tgcggtggtt ccggtggcgt      480

ttcttccctg cagtgctggt gtacagaggc catcaagaga gaccagagga gcagatggtg      540

gcataccgag gaagaaccac cttcatgcgc acagacatca gcaagggaag agttgcgctc      600

attatccaca atgtcacagc ctatgacaat ggcatctact gctgttactt ccaggaaggc      660

aggtcctatg accaggcaac catgaagctt atggtggcaa gccttggctc tgagccactt      720

attaaaatga agacacttga ggatgggagc atcttgctag agtgcacatc tgaagggtgg      780

tacccagagc cccgagctgt gtggagagac ccctatgatg aagttgtacc tgccctggag      840

gaggagtata cagctgacag agaaggcctc ttcacagtca ccatgactat aatcatcagg      900

gactgctctg tgaggaacat gacctgctct gtcaataaca ctctgctcag ccaggaggtg      960

gaaagtgtga ttctcattcc agaatccttc gtgcccagcc ttcctctgtg gatggtggct     1020

gtggctgtca ctctgcctgt agtaatgctg attctcctca catctggaag catctgcctt     1080

gtcaagaaac accgcaggaa gaaatctatt ctgtcagctg aaaaagaagc cgaatatgaa     1140

gagaaggaag ctgcacggca acttcaagag gaactgcgat ggagacgaac cctcttacat     1200

gctgctgacg tggtcctgga cccagataca gctcatcctg agctcttcct gtcagatgac     1260

cagagaagtg taatacgagg ctcttcgagg cagagtgtgc ctgacaaccc tgagagattt     1320

gactgccgtc catgtgtcct gggcagggaa agcttctcct cagggaagca ttactgggag     1380

gtggaggtgg aaaatgtaat ggtgtgggcc attggtgttt gtagagacag cgtggaaagg     1440

aaaggggagg ccctgttggt tcctcagaat ggcttctgga ccctggagat gtttggaagc     1500

cagtatcgag ccctgtcctc cccagaaaag atcatacctc tgaaagagcg tcttcaccgt     1560

atagctgtct tcctggactg tgagggtgga gatatttctt tctacaacat gagagacaga     1620

tcacacattt acacatgtcc tcctgtgact ttcactgggc ccctgagacc cttctttagg     1680

cttggttctg atgacagtcc cctgttcatc tgtccagcat tcacaggggc acagggagtt     1740

acaatacctg agggtggctt attcctatat aagacaagac caatttctca gagccttgta     1800

aggaagccat agctctctac acagtaccat ctgttggaga ctagacccca tgtccttcag     1860

atcacatgga gcatcttcca gctgccacct tcacacatac ttcaggccca gtcctcagat     1920

tactacatca tttcttctaa ctatgggcct aggtagagcc agtcttaggg gactattgct     1980

gtaatacagc tctctcctga gaagaaagtg tgagaagggc agaaaacttg gagtttcaac     2040

atgctgctct ggtcacagtg gatatcaggc aagagcaaca gggtggatca ggatgtaaga     2100

agtgagaact acagaggaag gagacagata aagatgaatt gaggccgaag atggaggaaa     2160

tggactgaag agctctgggg taagccctat gtgacagctg tggataggta ggagctaatg     2220

gtccattgat atccaaagcc aaagatttaa atatcacata gtgtgtctgg agtgtatatc     2280

tgtagaccta cacatgagag gaaacaatca tagtgatgaa ctggatgtaa gctggctcag     2340

acgtccctac aataaacact tctgagttcc atgtctgtgc tcagtaagaa tggcttgagg     2400

cttgcggtcc atgctgagca gccaggtcca catgaatcgg atttactaga gtaggtagca     2460

gttcaagttc cttaggctca ggatgtcttc ctttccccca agcccttccc ccttcaagat     2520

aggtctcact atgtagacca ggccagcctc cacctccaga gttctgggat taaagacaag     2580

cacaaccatg tccagtttat gagcttgtga tatatacaga agattaagtt ctgtgttctt     2640

gggttagtaa ctgttgagat ttgttttgag tcatgctctc actggctagc actgctcttg     2700

actttctctc cccatctttt tgttattgct tttcaagaca tggtttcact gtgtatttct     2760

ggctgataag ctgattttga attcacagag atctgcctct gcctcctgag tgctgggatt     2820

aaaggtgtgt tacactacgc ctggcttcac tctatctctt cagtgtgggg attataggtt     2880

tatactatca tgcctaacta atgtctgttg ctgcatatga catttgaact ttagaacaga     2940

aaaacaacta tacatattaa tatatattaa actaataata agc                       2983


<210> 104
<211> 514
<212> PRT
<213> Mus musculus

<400> 104
Met Glu Pro Thr Thr Ser Leu Arg Ser Cys Pro Ile Ala Ser Leu Leu 
1               5                   10                  15      


Phe Phe Leu Val Leu Ser Leu Phe Val Leu Val Ser Ala Gln Phe Thr 
            20                  25                  30          


Val Ile Gly Pro Ala Glu Pro Ile Leu Ala Met Val Gly Glu Asn Thr 
        35                  40                  45              


Thr Leu His Cys His Leu Ser Pro Glu Arg Asn Ala Glu Glu Met Glu 
    50                  55                  60                  


Val Arg Trp Phe Arg Trp Arg Phe Phe Pro Ala Val Leu Val Tyr Arg 
65                  70                  75                  80  


Gly His Gln Glu Arg Pro Glu Glu Gln Met Val Ala Tyr Arg Gly Arg 
                85                  90                  95      


Thr Thr Phe Met Arg Thr Asp Ile Ser Lys Gly Arg Val Ala Leu Ile 
            100                 105                 110         


Ile His Asn Val Thr Ala Tyr Asp Asn Gly Ile Tyr Cys Cys Tyr Phe 
        115                 120                 125             


Gln Glu Gly Arg Ser Tyr Asp Gln Ala Thr Met Lys Leu Met Val Ala 
    130                 135                 140                 


Ser Leu Gly Ser Glu Pro Leu Ile Lys Met Lys Thr Leu Glu Asp Gly 
145                 150                 155                 160 


Ser Ile Leu Leu Glu Cys Thr Ser Glu Gly Trp Tyr Pro Glu Pro Arg 
                165                 170                 175     


Ala Val Trp Arg Asp Pro Tyr Asp Glu Val Val Pro Ala Leu Glu Glu 
            180                 185                 190         


Glu Tyr Thr Ala Asp Arg Glu Gly Leu Phe Thr Val Thr Met Thr Ile 
        195                 200                 205             


Ile Ile Arg Asp Cys Ser Val Arg Asn Met Thr Cys Ser Val Asn Asn 
    210                 215                 220                 


Thr Leu Leu Ser Gln Glu Val Glu Ser Val Ile Leu Ile Pro Glu Ser 
225                 230                 235                 240 


Phe Val Pro Ser Leu Pro Leu Trp Met Val Ala Val Ala Val Thr Leu 
                245                 250                 255     


Pro Val Val Met Leu Ile Leu Leu Thr Ser Gly Ser Ile Cys Leu Val 
            260                 265                 270         


Lys Lys His Arg Arg Lys Lys Ser Ile Leu Ser Ala Glu Lys Glu Ala 
        275                 280                 285             


Glu Tyr Glu Glu Lys Glu Ala Ala Arg Gln Leu Gln Glu Glu Leu Arg 
    290                 295                 300                 


Trp Arg Arg Thr Leu Leu His Ala Ala Asp Val Val Leu Asp Pro Asp 
305                 310                 315                 320 


Thr Ala His Pro Glu Leu Phe Leu Ser Asp Asp Gln Arg Ser Val Ile 
                325                 330                 335     


Arg Gly Ser Ser Arg Gln Ser Val Pro Asp Asn Pro Glu Arg Phe Asp 
            340                 345                 350         


Cys Arg Pro Cys Val Leu Gly Arg Glu Ser Phe Ser Ser Gly Lys His 
        355                 360                 365             


Tyr Trp Glu Val Glu Val Glu Asn Val Met Val Trp Ala Ile Gly Val 
    370                 375                 380                 


Cys Arg Asp Ser Val Glu Arg Lys Gly Glu Ala Leu Leu Val Pro Gln 
385                 390                 395                 400 


Asn Gly Phe Trp Thr Leu Glu Met Phe Gly Ser Gln Tyr Arg Ala Leu 
                405                 410                 415     


Ser Ser Pro Glu Lys Ile Ile Pro Leu Lys Glu Arg Leu His Arg Ile 
            420                 425                 430         


Ala Val Phe Leu Asp Cys Glu Gly Gly Asp Ile Ser Phe Tyr Asn Met 
        435                 440                 445             


Arg Asp Arg Ser His Ile Tyr Thr Cys Pro Pro Val Thr Phe Thr Gly 
    450                 455                 460                 


Pro Leu Arg Pro Phe Phe Arg Leu Gly Ser Asp Asp Ser Pro Leu Phe 
465                 470                 475                 480 


Ile Cys Pro Ala Phe Thr Gly Ala Gln Gly Val Thr Ile Pro Glu Gly 
                485                 490                 495     


Gly Leu Phe Leu Tyr Lys Thr Arg Pro Ile Ser Gln Ser Leu Val Arg 
            500                 505                 510         


Lys Pro 
        


<210> 105
<211> 2945
<212> DNA
<213> Homo sapiens

<400> 105
agctttctca cttggtagca gtggcctctt gtgccttttt ctccaagatc acccaggctg       60

aagctcctga ggggactcac atcagttatc ttgctgctcc agaagggtgg gagatggcag      120

ttttcccaag ctccggtctc cccagatgtc tgctcaccct cattctcctc cagctgccca      180

aactggattc agctcccttt gacgtgattg gacccccgga gcccatcctg gccgttgtgg      240

gtgaggacgc cgagctgccc tgtcgcctgt ctccgaacgc gagcgccgag cacttggagc      300

tacgctggtt ccgaaagaag gtttcgccgg ccgtgctggt gcatagggac gggcgcgagc      360

aggaagccga gcagatgccc gagtaccgcg ggcgggcgac gctggtccag gacggcatcg      420

ccaaggggcg cgtggccttg aggatccgtg gcgtcagagt ctctgacgac ggggagtaca      480

cgtgcttttt cagggaggat ggaagctacg aagaagccct ggtgcatctg aaggtggctg      540

ctctgggctc tgaccctcac atcagtatgc aagttcaaga gaatggagaa atctgtctgg      600

agtgcacctc agtgggatgg tacccagagc cccaggtgca gtggagaact tccaagggag      660

agaagtttcc atctacatca gagtccagga atcctgatga agaaggtttg ttcactgtgg      720

ctgcttcagt gatcatcaga gacacttctg cgaaaaatgt gtcctgctac atccagaatc      780

tccttcttgg ccaggagaag aaagtagaaa tatccatacc agcttcctcc ctcccaaggc      840

tgactccctg gatagtggct gtggctgtca tcctgatggt tctaggactt ctcaccattg      900

ggtccatatt tttcacttgg agactataca acgaaagacc cagagagagg aggaatgaat      960

tcagctctaa agagagactc ctggaagaac tcaaatggaa aaaggctacc ttgcatgcag     1020

ttgatgtgac tctggaccca gacacagctc atccccacct ctttctttat gaggattcaa     1080

aatctgttcg actggaagat tcacgtcaga aactgcctga gaaaacagag agatttgact     1140

cctggccctg tgtgttgggc cgtgagacct tcacctcagg aaggcattac tgggaggtgg     1200

aggtgggaga caggactgac tgggcaatcg gcgtgtgtag ggagaatgtg atgaagaaag     1260

gatttgaccc catgactcct gagaatgggt tctgggctgt agagttgtat ggaaatgggt     1320

actgggccct cactcctctc cggacccctc tcccattggc agggccccca cgccgggttg     1380

ggattttcct agactatgaa tcaggagaca tctccttcta caacatgaat gatggatctg     1440

atatctatac tttctccaat gtcactttct ctggccccct ccggcccttc ttttgcctat     1500

ggtctagcgg taaaaagccc ctgaccatct gcccaattgc tgatgggcct gagagggtca     1560

cagtcattgc taatgcccag gacctttcta aggagatccc attgtccccc atgggggagg     1620

actctgcccc tagggatgca gacactctcc attctaagct aatccctacc caacccagcc     1680

aaggggcacc ttaaggaata tctcagctca tctgttttcc tttcctctaa cccctctcct     1740

ccatagcctt ctgaggcttc acctgctagc tttacccagt ctgtttcttc ctgttgggtg     1800

gcaattaatt aatcctgtga aggttacatt gctgctgcta gagagggtgg ggattgcacc     1860

ttccaaatct gtttctgtac caatatttgg gggatggagg ggtgactcaa actgcttcta     1920

gtgttctcct aatcccttaa gactagaacc tataggaaac tacttggagc aaactcaaag     1980

gacagattag ggatcgagat tgggtcaggt tagcatgggg ttgtggttga aatatcttgg     2040

tatccaggat aagggtatgt ggaaaaacag gctttaggca agtggaaaat tcaaaatgtg     2100

ctgtgaaagg acaatctcag gctgaaatcc cataaaggaa cttggaggga atattatgat     2160

ggagggaagt gaggtgaatc caggcacatg atgaacacct ggctcatcca tagagttttc     2220

acagcctata tcgcaaattt tctaagccac gtcctatagg acagaggaga ctggccccac     2280

ttctatgggt ctgagctgtg gaaaagggag agcagagagg aactgagatg agcagggatg     2340

aagggtcagg cagaaagcgt gatagaggag agaatttttg acaaaactca aaagttgttt     2400

gcacagctgt tctttgtacc ctgttccttt ctctgcgccc tcctgtttct cccttgcctg     2460

gaagtcattc caccctcaat ttgttgatcc acaagtttcc agttgtcctc ttctttttgt     2520

tatagcatct ctctatttca aagacattcc tagaagtcat ccttcagtga tatcaccact     2580

tgctcagtca ccatctcaac cttatgtcac ctcagccctc atctcaatgc ccaaacccct     2640

tacacacacc ttcagttagc ttcaactgcc tccgtttcca cactgtgcac ctttcacttt     2700

ccctacccag ctttcctaca tgctgcctct cctcagggtc ccctgaatgc tgcatcattg     2760

tgttcagtgc agctggactg attgcacctg tgtatttgcc cctgagcact ttcctttaca     2820

catgtggctt gtcttgccaa tagactccag gcttatacct tccatttcca tcgtattctc     2880

cagtttccag gatagacgtt gctcatcgtc tttacctaat aaataagttt gtctgattgc     2940

tgaaa                                                                 2945


<210> 106
<211> 526
<212> PRT
<213> Homo sapiens

<400> 106
Met Ala Val Phe Pro Ser Ser Gly Leu Pro Arg Cys Leu Leu Thr Leu 
1               5                   10                  15      


Ile Leu Leu Gln Leu Pro Lys Leu Asp Ser Ala Pro Phe Asp Val Ile 
            20                  25                  30          


Gly Pro Pro Glu Pro Ile Leu Ala Val Val Gly Glu Asp Ala Glu Leu 
        35                  40                  45              


Pro Cys Arg Leu Ser Pro Asn Ala Ser Ala Glu His Leu Glu Leu Arg 
    50                  55                  60                  


Trp Phe Arg Lys Lys Val Ser Pro Ala Val Leu Val His Arg Asp Gly 
65                  70                  75                  80  


Arg Glu Gln Glu Ala Glu Gln Met Pro Glu Tyr Arg Gly Arg Ala Thr 
                85                  90                  95      


Leu Val Gln Asp Gly Ile Ala Lys Gly Arg Val Ala Leu Arg Ile Arg 
            100                 105                 110         


Gly Val Arg Val Ser Asp Asp Gly Glu Tyr Thr Cys Phe Phe Arg Glu 
        115                 120                 125             


Asp Gly Ser Tyr Glu Glu Ala Leu Val His Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Pro His Ile Ser Met Gln Val Gln Glu Asn Gly Glu Ile 
145                 150                 155                 160 


Cys Leu Glu Cys Thr Ser Val Gly Trp Tyr Pro Glu Pro Gln Val Gln 
                165                 170                 175     


Trp Arg Thr Ser Lys Gly Glu Lys Phe Pro Ser Thr Ser Glu Ser Arg 
            180                 185                 190         


Asn Pro Asp Glu Glu Gly Leu Phe Thr Val Ala Ala Ser Val Ile Ile 
        195                 200                 205             


Arg Asp Thr Ser Ala Lys Asn Val Ser Cys Tyr Ile Gln Asn Leu Leu 
    210                 215                 220                 


Leu Gly Gln Glu Lys Lys Val Glu Ile Ser Ile Pro Ala Ser Ser Leu 
225                 230                 235                 240 


Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Val Ile Leu Met Val 
                245                 250                 255     


Leu Gly Leu Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Arg Leu Tyr 
            260                 265                 270         


Asn Glu Arg Pro Arg Glu Arg Arg Asn Glu Phe Ser Ser Lys Glu Arg 
        275                 280                 285             


Leu Leu Glu Glu Leu Lys Trp Lys Lys Ala Thr Leu His Ala Val Asp 
    290                 295                 300                 


Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr Glu 
305                 310                 315                 320 


Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Lys Leu Pro Glu 
                325                 330                 335     


Lys Thr Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu Thr 
            340                 345                 350         


Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg Thr 
        355                 360                 365             


Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Met Lys Lys Gly Phe 
    370                 375                 380                 


Asp Pro Met Thr Pro Glu Asn Gly Phe Trp Ala Val Glu Leu Tyr Gly 
385                 390                 395                 400 


Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Pro Leu Pro Leu Ala 
                405                 410                 415     


Gly Pro Pro Arg Arg Val Gly Ile Phe Leu Asp Tyr Glu Ser Gly Asp 
            420                 425                 430         


Ile Ser Phe Tyr Asn Met Asn Asp Gly Ser Asp Ile Tyr Thr Phe Ser 
        435                 440                 445             


Asn Val Thr Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp Ser 
    450                 455                 460                 


Ser Gly Lys Lys Pro Leu Thr Ile Cys Pro Ile Ala Asp Gly Pro Glu 
465                 470                 475                 480 


Arg Val Thr Val Ile Ala Asn Ala Gln Asp Leu Ser Lys Glu Ile Pro 
                485                 490                 495     


Leu Ser Pro Met Gly Glu Asp Ser Ala Pro Arg Asp Ala Asp Thr Leu 
            500                 505                 510         


His Ser Lys Leu Ile Pro Thr Gln Pro Ser Gln Gly Ala Pro 
        515                 520                 525     


<210> 107
<211> 3454
<212> DNA
<213> Mus musculus

<400> 107
aacagcacac agccttcttc cttctgaaga gctctctctt tggccccggg gtgacaagca       60

gcccttttca cttgatcact gtggctctgg ctcccttttc ctctgggtct gtcgaaatcg      120

cctgaagctc ttggcgggct tcattgcccc agttagctca gagatggcag ttcccaccaa      180

ctcctgcctc ctggtctgtc tgctcaccct cactgtccta cagctgccca cgctggattc      240

ggcagctccc ttcgatgtga ccgcacctca ggagccagtg ttggccctag tgggctcaga      300

tgccgagctg acctgtggct tttccccaaa cgcgagctca gaatacatgg agctgctgtg      360

gtttcgacag acgaggtcga cagcggtact tctataccgg gatggccagg agcaggaggg      420

ccagcagatg acggagtacc gcgggagggc gacgctggcg acagccgggc ttctagacgg      480

ccgcgctact ctgctgatcc gagatgtcag ggtctcagac cagggggagt accggtgcct      540

tttcaaagac aacgacgact tcgaggaggc cgccgtatac ctcaaagtgg ctgctgtggg      600

ttcagatcct caaatcagta tgacggttca agagaatgga gaaatggagc tggagtgcac      660

ctcctctgga tggtacccag agcctcaggt gcagtggaga acaggcaaca gagagatgct      720

accatccacg tcagagtcca agaagcataa tgaggaaggc ctgttcactg tggcagtttc      780

aatgatgatc agagacagct ccataaagaa catgtcctgc tgcatccaga atatcctcct      840

tggccagggg aaggaagtag agatctcctt accagctccc ttcgtgccaa ggctgactcc      900

ctggatagta gctgtggcta tcatcttact ggccttagga tttctcacca ttgggtccat      960

atttttcact tggaaactat acaaggaaag atccagtctg cggaagaagg aatttggctc     1020

taaagagaga cttctggaag aactcagatg caaaaagact gtactgcatg aagttgacgt     1080

gactctggat ccagacacag cccaccccca cctcttcctg tatgaagatt caaagtcagt     1140

tcgattggaa gattcacgtc agatcctgcc tgatagacca gagagatttg actcctggcc     1200

ctgtgtgttg ggccgtgaga cctttacttc agggagacat tactgggagg tggaggtggg     1260

agatagaact gactgggcca ttggtgtgtg tagggagaat gtggtgaaga aagggtttga     1320

ccccatgact cctgataatg ggttctgggc tgtggagttg tatggaaatg ggtactgggc     1380

cctcacccca ctcaggacct ctctccgatt agcagggccc cctcgcagag ttggggtttt     1440

tctggactat gacgcaggag acatttcctt ctacaacatg agtaacggat ctcttatcta     1500

tactttccct agcatctctt tctctggccc cctccgtccc ttcttttgtc tgtggtcctg     1560

tggtaaaaag cccctgacca tctgttcaac tgccaatggg cctgagaaag tcacagtcat     1620

tgctaatgtc caggacgaca ttcccttgtc cccgctgggg gaaggctgta cttctggaga     1680

caaagacact ctccattcta aactgatccc gttctcacct agccaagcgg caccataaca     1740

aatattccag cttcacgact ttgccttcct ttgactaatc cctcatgccc cgaagcttca     1800

gctgttggct tcttgcagcc ctgcttcttc ctggtggatg gagattaatt cacattggga     1860

aggttaggta tgttgctgcc agacaaggca ggaagaaagg ccatcctagt ttgtttctgt     1920

actaacagtg gggaggaaga gagctgaatc ctaaactatt tccagtgctc atattccttc     1980

aggccagagc ctatagagaa ggatttggta caatcactcg agggatcaag aggcaattag     2040

gttggcatgg aattatggca gaaacatctg gaataggggt atgtggaatg acaggtttta     2100

ggtaagggag aacaaaacca aaccatagga tgctgagaaa gaaagatctt ggactaaact     2160

cctaaaaaag cacttagaga agatatgaca ggcaaatgaa gtgaatttgg tctaatttga     2220

tacacttgcc ctgtccctag ggtttttcag ttatatctca atttttttgt tgttaattac     2280

atttttgaca gcttcataca tgtatataat gcattctaat tactctcact ctcctctatt     2340

ctgtcttatt tccctcccct cccctcatac cttccttctt gcttcaaacc tggcacactg     2400

agtttaatgg gctatcatgg gaacatggat ttagagcttt cctctgagct caagagagca     2460

ggtgtgactg aatacagtga tttcccctct cctacaatca atcagcagtc aatagctcag     2520

ctgggagggg tagggcctca tgagacttcc cctatcaagg ctaaatgttg aaagggccag     2580

tttttagcac ctgtgagatc atgattgcaa gagcccagaa gacagcattg ctcggtcatt     2640

ctccctaccc tttggctttt ctggtctttt gtcctctctt tcaggatgtg tctgaactct     2700

gtatcttaag ttttctatgt catgttctat aagatagagg agactggccc tgcttgtttg     2760

agagcaatgt gagcaagcta gcaagagaca gaaaggagcg gagatgaata ggggtagaga     2820

aaatttttaa acaaaccctc caggtgtgtg tgtgtgtgtg tgtgtcttcc tcttttttga     2880

cctccctaaa ggtcaatcca acctcacatt attgactcca ctaggtgggg gttctgtgtg     2940

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttttaaga tagaggttta ctatgtagct     3000

taggctggct ttgaattcct gatcctcctg cctctacctt ccaagtgctg gaaacatagc     3060

cacatccacc acccctatcc agtccacctg gtttgattca gcaacgctca ggtagcatcg     3120

ctgtttgatc tggagctgcc agctccctcg gcccccactg caatgcttaa ccccctcaca     3180

ggcaccttcc cttgcctaac actgccatcc ttttccacac tgagccattt gctcaatgta     3240

gcctacccag gtatcctgct ttctggtccc caaagttaca ccatgatgct cagcacagct     3300

ggacagtttg tcccaatttg tgtgtgtcct cctgtttgta tgggacttct ttttgtcaat     3360

ggcctgtgtg tgtatccaag ctcttccact tctattgtat ttttccggct tctaaaacag     3420

atgttaccaa ataaagaaag agaaagaaaa aaaa                                 3454


<210> 108
<211> 524
<212> PRT
<213> Mus musculus

<400> 108
Met Ala Val Pro Thr Asn Ser Cys Leu Leu Val Cys Leu Leu Thr Leu 
1               5                   10                  15      


Thr Val Leu Gln Leu Pro Thr Leu Asp Ser Ala Ala Pro Phe Asp Val 
            20                  25                  30          


Thr Ala Pro Gln Glu Pro Val Leu Ala Leu Val Gly Ser Asp Ala Glu 
        35                  40                  45              


Leu Thr Cys Gly Phe Ser Pro Asn Ala Ser Ser Glu Tyr Met Glu Leu 
    50                  55                  60                  


Leu Trp Phe Arg Gln Thr Arg Ser Thr Ala Val Leu Leu Tyr Arg Asp 
65                  70                  75                  80  


Gly Gln Glu Gln Glu Gly Gln Gln Met Thr Glu Tyr Arg Gly Arg Ala 
                85                  90                  95      


Thr Leu Ala Thr Ala Gly Leu Leu Asp Gly Arg Ala Thr Leu Leu Ile 
            100                 105                 110         


Arg Asp Val Arg Val Ser Asp Gln Gly Glu Tyr Arg Cys Leu Phe Lys 
        115                 120                 125             


Asp Asn Asp Asp Phe Glu Glu Ala Ala Val Tyr Leu Lys Val Ala Ala 
    130                 135                 140                 


Val Gly Ser Asp Pro Gln Ile Ser Met Thr Val Gln Glu Asn Gly Glu 
145                 150                 155                 160 


Met Glu Leu Glu Cys Thr Ser Ser Gly Trp Tyr Pro Glu Pro Gln Val 
                165                 170                 175     


Gln Trp Arg Thr Gly Asn Arg Glu Met Leu Pro Ser Thr Ser Glu Ser 
            180                 185                 190         


Lys Lys His Asn Glu Glu Gly Leu Phe Thr Val Ala Val Ser Met Met 
        195                 200                 205             


Ile Arg Asp Ser Ser Ile Lys Asn Met Ser Cys Cys Ile Gln Asn Ile 
    210                 215                 220                 


Leu Leu Gly Gln Gly Lys Glu Val Glu Ile Ser Leu Pro Ala Pro Phe 
225                 230                 235                 240 


Val Pro Arg Leu Thr Pro Trp Ile Val Ala Val Ala Ile Ile Leu Leu 
                245                 250                 255     


Ala Leu Gly Phe Leu Thr Ile Gly Ser Ile Phe Phe Thr Trp Lys Leu 
            260                 265                 270         


Tyr Lys Glu Arg Ser Ser Leu Arg Lys Lys Glu Phe Gly Ser Lys Glu 
        275                 280                 285             


Arg Leu Leu Glu Glu Leu Arg Cys Lys Lys Thr Val Leu His Glu Val 
    290                 295                 300                 


Asp Val Thr Leu Asp Pro Asp Thr Ala His Pro His Leu Phe Leu Tyr 
305                 310                 315                 320 


Glu Asp Ser Lys Ser Val Arg Leu Glu Asp Ser Arg Gln Ile Leu Pro 
                325                 330                 335     


Asp Arg Pro Glu Arg Phe Asp Ser Trp Pro Cys Val Leu Gly Arg Glu 
            340                 345                 350         


Thr Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asp Arg 
        355                 360                 365             


Thr Asp Trp Ala Ile Gly Val Cys Arg Glu Asn Val Val Lys Lys Gly 
    370                 375                 380                 


Phe Asp Pro Met Thr Pro Asp Asn Gly Phe Trp Ala Val Glu Leu Tyr 
385                 390                 395                 400 


Gly Asn Gly Tyr Trp Ala Leu Thr Pro Leu Arg Thr Ser Leu Arg Leu 
                405                 410                 415     


Ala Gly Pro Pro Arg Arg Val Gly Val Phe Leu Asp Tyr Asp Ala Gly 
            420                 425                 430         


Asp Ile Ser Phe Tyr Asn Met Ser Asn Gly Ser Leu Ile Tyr Thr Phe 
        435                 440                 445             


Pro Ser Ile Ser Phe Ser Gly Pro Leu Arg Pro Phe Phe Cys Leu Trp 
    450                 455                 460                 


Ser Cys Gly Lys Lys Pro Leu Thr Ile Cys Ser Thr Ala Asn Gly Pro 
465                 470                 475                 480 


Glu Lys Val Thr Val Ile Ala Asn Val Gln Asp Asp Ile Pro Leu Ser 
                485                 490                 495     


Pro Leu Gly Glu Gly Cys Thr Ser Gly Asp Lys Asp Thr Leu His Ser 
            500                 505                 510         


Lys Leu Ile Pro Phe Ser Pro Ser Gln Ala Ala Pro 
        515                 520                 


<210> 109
<211> 2926
<212> DNA
<213> Homo sapiens

<400> 109
acatctgctt cctgtaggcc ctctgggcag aagcatgcgc tggtgtctcc tcctgatctg       60

ggcccagggg ctgaggcagg ctcccctcgc ctcaggaatg atgacaggca caatagaaac      120

aacggggaac atttctgcag agaaaggtgg ctctatcatc ttacaatgtc acctctcctc      180

caccacggca caagtgaccc aggtcaactg ggagcagcag gaccagcttc tggccatttg      240

taatgctgac ttggggtggc acatctcccc atccttcaag gatcgagtgg ccccaggtcc      300

cggcctgggc ctcaccctcc agtcgctgac cgtgaacgat acaggggagt acttctgcat      360

ctatcacacc taccctgatg ggacgtacac tgggagaatc ttcctggagg tcctagaaag      420

ctcagtggct gagcacggtg ccaggttcca gattccattg cttggagcca tggccgcgac      480

gctggtggtc atctgcacag cagtcatcgt ggtggtcgcg ttgactagaa agaagaaagc      540

cctcagaatc cattctgtgg aaggtgacct caggagaaaa tcagctggac aggaggaatg      600

gagccccagt gctccctcac ccccaggaag ctgtgtccag gcagaagctg cacctgctgg      660

gctctgtgga gagcagcggg gagaggactg tgccgagctg catgactact tcaatgtcct      720

gagttacaga agcctgggta actgcagctt cttcacagag actggttagc aaccagaggc      780

atcttctgga agatacactt ttgtctttgc tattatagat gaatatataa gcagctgtac      840

tctccatcag tgctgcgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgttc agttgagtga      900

ataaatgtca tcctcttctc catcttcatt tccttggcct tttcgttcta ttccattttg      960

cattatggca ggcctagggt gagtaacgtg gatcttgatc ataaatgcaa aattaaaaaa     1020

tatcttgacc tggttttaaa tctggcagtt tgagcagatc ctatgtctct gagagacaca     1080

ttcctcataa tggccagcat tttgggctac aaggttttgt ggttgatgat gaggatggca     1140

tgactgcaga gccatcctca tctcattttt tcacgtcatt ttcagtaact ttcactcatt     1200

caaaggcagg ttataagtaa gtcctggtag cagcctctat ggggagattt gagagtgact     1260

aaatcttggt atctgccctc aagaacttac agttaaatgg ggagacaatg ttgtcatgaa     1320

aaggtattat agtaaggaga gaaggagaca tacacaggcc ttcaggaaga gacgacagtt     1380

tggggtgagg tagttggcat aggcttatct gtgatgaagt ggcctgggag caccaagggg     1440

atgttgaggc tagtctggga ggagcaggag ttttgtctag ggaacttgta ggaaattctt     1500

ggagctgaaa gtcccacaaa gaaggccctg gcaccaaggg agtcagcaaa cttcagattt     1560

tattctctgg gcaggcattt caagtttcct tttgctgtga catactcatc cattagacag     1620

cctgatacag gcctgtagcc tcttccggcc gtgtgtgctg gggaagcccc aggaaacgca     1680

catgcccaca cagggagcca agtcgtagca tttgggcctt gatctacctt ttctgcatca     1740

atacactctt gagcctttga aaaaagaacg tttcccacta aaaagaaaat gtggattttt     1800

aaaataggga ctcttcctag gggaaaaagg ggggctggga gtgatagagg gtttaaaaaa     1860

taaacacctt caaactaact tcttcgaacc cttttattca ctccctgacg actttgtgct     1920

ggggttgggg taactgaacc gcttatttct gtttaattgc attcaggctg gatcttagaa     1980

gacttttatc cttccaccat ctctctcaga ggaatgagcg gggaggttgg atttactggt     2040

gactgatttt ctttcatggg ccaaggaact gaaagagaat gtgaagcaag gttgtgtctt     2100

gcgcatggtt aaaaataaag cattgtcctg cttcctaaga cttagactgg ggttgacaat     2160

tgttttagca acaagacaat tcaactattt ctcctaggat ttttattatt attatttttt     2220

cacttttcta ccaaatgggt tacataggaa gaatgaactg aaatctgtcc agagctccaa     2280

gtcctttgga agaaagatta gatgaacgta aaaatgttgt tgtttgctgt ggcagtttac     2340

agcatttttc ttgcaaaatt agtgcaaatc tgttggaaat agaacacaat tcacaaattg     2400

gaagtgaact aaaatgtaat gacgaaaagg gagtagtgtt ttgatttgga ggaggtgtat     2460

attcggcaga ggttggactg agagttgggt gttatttaac ataattatgg taattgggaa     2520

acatttataa acactattgg gatggtgata aaatacaaaa gggcctatag atgttagaaa     2580

tgggtcaggt tactgaaatg ggattcaatt tgaaaaaaat ttttttaaat agaactcact     2640

gaactagatt ctcctctgag aaccagagaa gaccatttca tagttggatt cctggagaca     2700

tgcgctatcc accacgtagc cactttccac atgtggccat caaccactta agatggggtt     2760

agtttaaatc aagatgtgct gttataattg gtataagcat aaaatcacac tagattctgg     2820

agatttaata tgaataataa gaatactatt tcagtagttt tggtatattg tgtgtcaaaa     2880

atgataatat tttggatgta ttgggtgaaa taaaatatta acatta                    2926


<210> 110
<211> 244
<212> PRT
<213> Homo sapiens

<400> 110
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210> 111
<211> 726
<212> DNA
<213> Mus musculus

<400> 111
atgcatggct ggctgctcct ggtctgggtc caggggctga tacaggctgc cttcctcgct       60

acaggagcca cagcaggcac gatagataca aagaggaaca tctctgcaga ggaaggtggc      120

tctgtcatct tacagtgtca cttctcctct gacacagctg aagtgaccca agtcgactgg      180

aagcagcagg accagcttct ggccatttat agtgttgacc tggggtggca tgtcgcttca      240

gtcttcagtg atcgggtggt cccaggcccc agcctaggcc tcaccttcca gtctctgaca      300

atgaatgaca cgggagagta cttctgtacc tatcatacgt atcctggtgg gatttacaag      360

gggagaatat tcctgaaggt ccaagaaagc tcagtggctc agttccagac tgccccgctt      420

ggaggaacca tggctgctgt gctgggactc atttgcttaa tggtcacagg agtgactgta      480

ctggctagaa agaagtctat tagaatgcat tctatagaaa gtggccttgg gagaacagaa      540

gcggagccac aggaatggaa cctgaggagt ctctcatccc ctggaagccc tgtccagaca      600

caaactgccc ctgctggtcc ctgtggagag caggcagaag atgactatgc tgacccacag      660

gaatacttta atgtcctgag ctacagaagc ctagagagct tcattgctgt atcgaagact      720

ggctaa                                                                 726


<210> 112
<211> 241
<212> PRT
<213> Mus musculus

<400> 112
Met His Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Pro Leu Gly Gly Thr Met 
    130                 135                 140                 


Ala Ala Val Leu Gly Leu Ile Cys Leu Met Val Thr Gly Val Thr Val 
145                 150                 155                 160 


Leu Ala Arg Lys Lys Ser Ile Arg Met His Ser Ile Glu Ser Gly Leu 
                165                 170                 175     


Gly Arg Thr Glu Ala Glu Pro Gln Glu Trp Asn Leu Arg Ser Leu Ser 
            180                 185                 190         


Ser Pro Gly Ser Pro Val Gln Thr Gln Thr Ala Pro Ala Gly Pro Cys 
        195                 200                 205             


Gly Glu Gln Ala Glu Asp Asp Tyr Ala Asp Pro Gln Glu Tyr Phe Asn 
    210                 215                 220                 


Val Leu Ser Tyr Arg Ser Leu Glu Ser Phe Ile Ala Val Ser Lys Thr 
225                 230                 235                 240 


Gly 
    


<210> 113
<211> 911
<212> DNA
<213> Homo sapiens

<400> 113
agagaggggc aggctggtcc cctgacaggt tgaagcaagt agacgcccag gagccccggg       60

agggggctgc agtttccttc cttccttctc ggcagcgctc cgcgccccca tcgcccctcc      120

tgcgctagcg gaggtgatcg ccgcggcgat gccggaggag ggttcgggct gctcggtgcg      180

gcgcaggccc tatgggtgcg tcctgcgggc tgctttggtc ccattggtcg cgggcttggt      240

gatctgcctc gtggtgtgca tccagcgctt cgcacaggct cagcagcagc tgccgctcga      300

gtcacttggg tgggacgtag ctgagctgca gctgaatcac acaggacctc agcaggaccc      360

caggctatac tggcaggggg gcccagcact gggccgctcc ttcctgcatg gaccagagct      420

ggacaagggg cagctacgta tccatcgtga tggcatctac atggtacaca tccaggtgac      480

gctggccatc tgctcctcca cgacggcctc caggcaccac cccaccaccc tggccgtggg      540

aatctgctct cccgcctccc gtagcatcag cctgctgcgt ctcagcttcc accaaggttg      600

taccattgcc tcccagcgcc tgacgcccct ggcccgaggg gacacactct gcaccaacct      660

cactgggaca cttttgcctt cccgaaacac tgatgagacc ttctttggag tgcagtgggt      720

gcgcccctga ccactgctgc tgattagggt tttttaaatt ttattttatt ttatttaagt      780

tcaagagaaa aagtgtacac acaggggcca cccggggttg gggtgggagt gtggtggggg      840

gtagtggtgg caggacaaga gaaggcattg agctttttct ttcattttcc tattaaaaaa      900

tacaaaaatc a                                                           911


<210> 114
<211> 193
<212> PRT
<213> Homo sapiens

<400> 114
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210> 115
<211> 842
<212> DNA
<213> Mus musculus

<400> 115
gaaggtgcca aaagctccag gggatttccc tgccctccga gaagaggccc agttcttccc       60

ctgcatcgga catccccgag gttctaaggg caggtcaagg caggcagaag cttcaaaagc      120

tcggctgagg aggctacagc ttcccgctgc cttcaggccg ctgcttccgt gcagggatgc      180

cggaggaagg tcgcccttgc ccctgggttc gctggagcgg gaccgcgttc cagcgccaat      240

ggccatggct gctgctggtg gtgtttatta ctgtgttttg ctgttggttt cattgtagcg      300

gactactcag taagcagcaa cagaggctgc tggagcaccc tgagccgcac acagctgagt      360

tacagctgaa tctcacagtt cctcggaagg accccacact gcgctgggga gcaggcccag      420

ccttgggaag gtccttcaca cacggaccag agctggagga gggccatctg cgtatccatc      480

aagatggcct ctacaggctg catatccagg tgacactggc caactgctct tccccaggca      540

gcaccctgca gcacagggcc accctggctg tgggcatctg ctcccccgct gcgcacggca      600

tcagcttgct gcgtgggcgc tttggacagg actgtacagt ggcattacag cgcctgacat      660

acctggtcca cggagatgtc ctctgtacca acctcaccct gcctctgctg ccgtcccgca      720

acgctgatga gaccttcttt ggagttcagt ggatatgccc ttgaccacaa ctccaggatg      780

acttgtgaat attttttttc ttttcaagtt ctacgtattt ataaatgtat atagtacaca      840

ta                                                                     842


<210> 116
<211> 195
<212> PRT
<213> Mus musculus

<400> 116
Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      


Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          


Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              


Gln Arg Leu Leu Glu His Pro Glu Pro His Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  


Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly 
                85                  90                  95      


His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val 
            100                 105                 110         


Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala 
        115                 120                 125             


Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu 
    130                 135                 140                 


Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu 
145                 150                 155                 160 


Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro 
                165                 170                 175     


Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         


Ile Cys Pro 
        195 


<210> 117
<211> 3779
<212> DNA
<213> Homo sapiens

<400> 117
gtcattttcc tacgcgccct ctgacatcag ccaccttctc tgtagctagt ttctctgcac       60

acaacttaat ccctggcaat gaaaaatgaa cctctccccc acccttgctg ccgcctctcg      120

cctcacgccc ccagagaaga gtttctccac caggcagcag gtgaaggttt ttttccaagt      180

cacatgattc aggattcagg gggagaatcc ttcttggaac agagatgggc ccagaactga      240

atcagatgaa gagagataag gtgtgatgtg gggaagacta tataaagaat ggacccaggg      300

ctgcagcaag cactcaacgg aatggcccct cctggagaca cagccatgca tgtgccggcg      360

ggctccgtgg ccagccacct ggggaccacg agccgcagct atttctattt gaccacagcc      420

actctggctc tgtgccttgt cttcacggtg gccactatta tggtgttggt cgttcagagg      480

acggactcca ttcccaactc acctgacaac gtccccctca aaggaggaaa ttgctcagaa      540

gacctcttat gtatcctgaa aagggctcca ttcaagaagt catgggccta cctccaagtg      600

gcaaagcatc taaacaaaac caagttgtct tggaacaaag atggcattct ccatggagtc      660

agatatcagg atgggaatct ggtgatccaa ttccctggtt tgtacttcat catttgccaa      720

ctgcagtttc ttgtacaatg cccaaataat tctgtcgatc tgaagttgga gcttctcatc      780

aacaagcata tcaaaaaaca ggccctggtg acagtgtgtg agtctggaat gcaaacgaaa      840

cacgtatacc agaatctctc tcaattcttg ctggattacc tgcaggtcaa caccaccata      900

tcagtcaatg tggatacatt ccagtacata gatacaagca cctttcctct tgagaatgtg      960

ttgtccatct tcttatacag taattcagac tgaacagttt ctcttggcct tcaggaagaa     1020

agcgcctctc taccatacag tatttcatcc ctccaaacac ttgggcaaaa agaaaacttt     1080

agaccaagac aaactacaca gggtattaaa tagtatactt ctccttctgt ctcttggaaa     1140

gatacagctc cagggttaaa aagagagttt ttagtgaagt atctttcaga tagcaggcag     1200

ggaagcaatg tagtgtggtg ggcagagccc cacacagaat cagaagggat gaatggatgt     1260

cccagcccaa cctctaattc actgtatggt cttgatctat ttcttctgtt ttgagagcct     1320

ccagttaaaa tggggctcca gtaccagagc agctagcaac tctgccctaa tgggaaatga     1380

aggggagctg ggtgtgagtg tttacactgt gcccttcacg ggatacttct tttatctgca     1440

gatggcctaa tacttagttg tccaagtcgc gatcaaggac tctctcacac aggaaacttc     1500

cctatactgg cagatacact tgtgactgaa ccatgcccag tttatgcctg tctgactgtc     1560

actctggcac taggaggctg atcttgtact ccatatgacc ccacccctag gaacccccag     1620

ggaaaaccag gctgggacag ccccctgttc ctgagatgga aagcacaaat ttaatacacc     1680

accacaatgg aaaacaagtt caaagacttt tacttacaga tcctggacag aaagggcata     1740

atgagtctga agggcagtcc tccttctcta ggttacatga ggcaggaata agaagtcaga     1800

cagagacagc aagacagtta acaatgtagg taaagaaata gggtgtggtc actctcaatt     1860

cactggcaaa tgcctgaatg gtctgtctga aggaagcaac agagaagtgg ggaatccagt     1920

ctgctaggca ggaaagatgc ctctaagttc ttgtctctgg ccagaggtgt ggtatagaac     1980

cagaaaccca tatcaagggt gactaagccc ggcttctggt atgagaaatt aaacttgtat     2040

acaaaatggt tgccaaggca acataaaatt ataagaattc actatacctt cccctccctg     2100

gaactcagga tccaagtcta gaaaatgaaa ggactgggtt tgaattgctt caaaacctct     2160

tccatctcag aagaccagac cctgggaact gagattccag acacaatttt ggaagctctc     2220

caaccaaaat aaggcccccc taccccagta tataattgaa gacactagta acacctgact     2280

gcatctcatc tcagcagagc cagaatatgg ggacaaggtt cagggtgccc tgctgaatgg     2340

tgtgaacagc aggatctcaa ggatgtaatg gaaagaacta ccacactgac catccagaat     2400

ctaagagacc atctgggtgt ttgggaaacc atctgacgag gcctgactct attccagtta     2460

gattgacaat aattgagcag caggcatttt tcatttctgg tcaggaaagc attgtgcctt     2520

tagcaaacaa tcagtgtgca acagtgatgt ggtcatctag ccagggaatg gctgctccat     2580

cccctgcata atatattcct gcttcaaaca cctctcagaa aaccagttcc gcgagggttt     2640

ttatatcccc acaaagttgt tgagagacaa tgatgaccct ggaagtgggg aggaggactt     2700

ctgagaaaca gcaacctctc tcctgattgg ggtagccatg agatttctct agctatatcc     2760

aacttggcat ctgtacatca tctttggagg aacatcttat ttgtggaagg accttgacaa     2820

gccgtttgag atggaatgta ggccctgatg ttatgcttca gtaaaaaaag atggaagctt     2880

ccctgctata ccaaaacatg gagcaaaatt tgcatttttc tcaagaagga gagaaaagga     2940

gtaggactcc agcaaagttt gtcagaagga aagctagaaa agatttaaaa gaaaaaaaga     3000

aagaacaaat cagcagtggt ggtatggatg aaagggactt gagagaacaa aaatggctaa     3060

gggaaaattt taagtcatct gctgagcagt gtgctgtgtc aacctcctcc taggtctcct     3120

ctatgaaata tttagtaaag tctacatttc tctttaactc tttctgtgag tagattcttt     3180

gggagaagca ggcattggaa gaggtgttga attcagcaag ccaaatggtc tgtggtaaaa     3240

aacaaaacag actttgagac tcaaggctaa aaaaacaggg aaatggctgg catttgagtc     3300

acacactaac tgcataggac aaatgaatct tgcttaaacc aactcatgca ttcttgaaaa     3360

ggtatatgca acccaactgt gtgttaacta agcaattttt ttgccatctc acattctaac     3420

tcgagaaaga ttccattttc atttttcacc aactgttctc tgagcagagg tacctgactt     3480

ttgcactgtg agtggtttct aatctcagtc tctgtcaagc aatgctaaga aagccaacac     3540

ctaaagacac aaggggtaca tcatttaaat gaataatgta accaaacaaa caaaaaaaga     3600

gaataatcat taataactca actgatagat atgtagggag taggcaaccc aggaagttta     3660

aaactaaatt ctgttactct tgagggttaa ccagcccctg ggaatgttat gagcaaatga     3720

tactccatga gtaaaatgat atctatgcaa gtaaaataaa taatttatct aactgggaa      3779


<210> 118
<211> 234
<212> PRT
<213> Homo sapiens

<400> 118
Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210> 119
<211> 2228
<212> DNA
<213> Mus musculus

<400> 119
agattaatcc caggcgatga aaaatgaacc tctcccccac ccttgcagcc acccttcgcc       60

tcacgccccc agagaagagt ttctccatcc ggcaactggt gaaggctttt ttccaagtca      120

catgatccag gatgcagggg aaaatccttc ttggaacaga gctgggtaca gaaccgaatc      180

agatgaggag agataaggtg tgatgtggga cagactatat aaagcatgga gccagggctg      240

caacaagcag gcagctgtgg ggctccttcc cctgacccag ccatgcaggt gcagcccggc      300

tcggtagcca gcccctggag aagcacgagg ccctggagaa gcacaagtcg cagctacttc      360

tacctcagca ccaccgcact ggtgtgcctt gttgtggcag tggcgatcat tctggtactg      420

gtagtccaga aaaaggactc cactccaaat acaactgaga aggcccccct taaaggagga      480

aattgctcag aggatctctt ctgtaccctg aaaagtactc catccaagaa gtcatgggcc      540

tacctccaag tgtcaaagca tctcaacaat accaaactgt catggaacga agatggcacc      600

atccacggac tcatatacca ggacgggaac ctgatagtcc aattccctgg cttgtacttc      660

atcgtttgcc aactgcagtt cctcgtgcag tgctcaaatc attctgtgga cctgacattg      720

cagctcctca tcaattccaa gatcaaaaag cagacgttgg taacagtgtg tgagtctgga      780

gttcagagta agaacatcta ccagaatctc tctcagtttt tgctgcatta cttacaggtc      840

aactctacca tatcagtcag ggtggataat ttccagtatg tggatacaaa cactttccct      900

cttgataatg tgctatccgt cttcttatat agtagctcag actgaatagt tgttcttaac      960

ctttatgaaa atgctgtcta ccatacagta cttcatctgt ccaaacatgg gccaaagaaa     1020

atattaggac aactcaaact aagcatgtga gttagtgcac ttctctttct gtcctttgga     1080

aaaatacaaa cccaggattt agaaagtgga gtctccttca gatgcacaaa caggaaagaa     1140

tgtgatatgt gcacagagac ctacttgggc actagaaggg gttgagttgt cccagtataa     1200

ccactaattc actgaccttg agccattttt ccttcccctg gaacttgggg tctgaatctg     1260

gaaaagtagg agatgagatt tacatttccc caatattttc ttcaactcag aagacgagac     1320

tgtggagctg agctccctac acagatgaag gcctcccatg gcatgaggaa aatgatggta     1380

ccagtaatgt ctgtctgact gtcatctcag caagtcctaa ggacttccat gctgccttgt     1440

tgaaagatac tctaacctct tgtaatgggc aaagtgatcc tgtctctcac tgaggggagt     1500

agctgctgcc atctcctgag acatacatgg agacattttc tgcccaaatt ccattctgtg     1560

tgcagttttt aagtattccc ccaaaagttc ttgacaatga gaactttgaa tgtgggaaga     1620

gcttctggac agcaaacatt aacagcttct cctgaccaga gagaccatgc aagcttggtc     1680

ttagacccat caagcttgag gtttctacat tgtgggagac agacttttga caaaccattt     1740

gagttgatgt ctgggcccct gggagttctc cttcagtaag gagagcaagc cgttctagtg     1800

ctgtgtcaga ggatggagta aaatagacac ttttctgaag gaaaggagaa caaagttcca     1860

gaaaaaggct agaaaatgtt taaaaggaaa agaaaaaact cagcttttct catatgagag     1920

gaacccagaa aaacaacact gaaaaagaag agtggctctg tcaacctcct cttaggtctc     1980

ctcctctcta gttattggga aaggagttgc atggtacagg acaagttctg gtgtgtggtc     2040

aaatagaatc agatgtggag aacaccatgc agagaataag gagacctgtc atatttgtgt     2100

tgtactcaaa tgaggggcaa atgaatctta ggctaaatca aataacagtc tctgtcaagc     2160

tgtgctcaga aagtcaacca ctgaagatgg agggtgaggc acgtcattta aaaaaagtga     2220

aatgtagc                                                              2228


<210> 120
<211> 239
<212> PRT
<213> Mus musculus

<400> 120
Met Glu Pro Gly Leu Gln Gln Ala Gly Ser Cys Gly Ala Pro Ser Pro 
1               5                   10                  15      


Asp Pro Ala Met Gln Val Gln Pro Gly Ser Val Ala Ser Pro Trp Arg 
            20                  25                  30          


Ser Thr Arg Pro Trp Arg Ser Thr Ser Arg Ser Tyr Phe Tyr Leu Ser 
        35                  40                  45              


Thr Thr Ala Leu Val Cys Leu Val Val Ala Val Ala Ile Ile Leu Val 
    50                  55                  60                  


Leu Val Val Gln Lys Lys Asp Ser Thr Pro Asn Thr Thr Glu Lys Ala 
65                  70                  75                  80  


Pro Leu Lys Gly Gly Asn Cys Ser Glu Asp Leu Phe Cys Thr Leu Lys 
                85                  90                  95      


Ser Thr Pro Ser Lys Lys Ser Trp Ala Tyr Leu Gln Val Ser Lys His 
            100                 105                 110         


Leu Asn Asn Thr Lys Leu Ser Trp Asn Glu Asp Gly Thr Ile His Gly 
        115                 120                 125             


Leu Ile Tyr Gln Asp Gly Asn Leu Ile Val Gln Phe Pro Gly Leu Tyr 
    130                 135                 140                 


Phe Ile Val Cys Gln Leu Gln Phe Leu Val Gln Cys Ser Asn His Ser 
145                 150                 155                 160 


Val Asp Leu Thr Leu Gln Leu Leu Ile Asn Ser Lys Ile Lys Lys Gln 
                165                 170                 175     


Thr Leu Val Thr Val Cys Glu Ser Gly Val Gln Ser Lys Asn Ile Tyr 
            180                 185                 190         


Gln Asn Leu Ser Gln Phe Leu Leu His Tyr Leu Gln Val Asn Ser Thr 
        195                 200                 205             


Ile Ser Val Arg Val Asp Asn Phe Gln Tyr Val Asp Thr Asn Thr Phe 
    210                 215                 220                 


Pro Leu Asp Asn Val Leu Ser Val Phe Leu Tyr Ser Ser Ser Asp 
225                 230                 235                 


<210> 121
<211> 2744
<212> DNA
<213> Homo sapiens

<400> 121
atcacttgtg aatttttgtt ttccacagct ctcatttctc caaaaatgtg tttgagccac       60

ttggaaaata tgcctttaag ccattcaaga actcaaggag ctcagagatc atcctggaag      120

ctgtggctct tttgctcaat agttatgttg ctatttcttt gctccttcag ttggctaatc      180

tttatttttc tccaattaga gactgctaag gagccctgta tggctaagtt tggaccatta      240

ccctcaaaat ggcaaatggc atcttctgaa cctccttgcg tgaataaggt gtctgactgg      300

aagctggaga tacttcagaa tggcttatat ttaatttatg gccaagtggc tcccaatgca      360

aactacaatg atgtagctcc ttttgaggtg cggctgtata aaaacaaaga catgatacaa      420

actctaacaa acaaatctaa aatccaaaat gtaggaggga cttatgaatt gcatgttggg      480

gacaccatag acttgatatt caactctgag catcaggttc taaaaaataa tacatactgg      540

ggtatcattt tactagcaaa tccccaattc atctcctaga gacttgattt gatctcctca      600

ttcccttcag cacatgtaga ggtgccagtg ggtggattgg agggagaaga tattcaattt      660

ctagagtttg tctgtctaca aaaatcaaca caaacagaac tcctctgcac gtgaattttc      720

atctatcatg cctatctgaa agagactcag gggaagagcc aaagactttt ggttggatct      780

gcagagatac ttcattaatc catgataaaa caaatatgga tgacagagga catgtgcttt      840

tcaaagaatc tttatctaat tcttgaattc atgagtggaa aaatggagtt ctattcccat      900

ggaagattta cctggtatgc aaaaaggatc tggggcagta gcctggcttt gttctcatat      960

tcttgggctg ctgtaattca ttcttctcat actcccatct tctgagaccc tcccaataaa     1020

aagtagactg ataggatggc cacagatatg cctaccatac cctactttag atatggtggt     1080

gttagaagat aaagaacaat ctgagaacta ttggaataga ggtacaagtg gcataaaatg     1140

gaatgtacgc tatctggaaa tttctcttgg ttttatcttc ctcaggatgc agggtgcttt     1200

aaaaagcctt atcaaaggag tcattccgaa ccctcacgta gagctttgtg agaccttact     1260

gttggtgtgt gtgtctaaac attgctaatt gtaaagaaag agtaaccatt agtaatcatt     1320

aggtttaacc ccagaatggt attatcatta ctggattatg tcatgtaatg atttagtatt     1380

tttagctagc tttccacagt ttgcaaagtg ctttcgtaaa acagttagca attctatgaa     1440

gttaattggg caggcatttg ggggaaaatt ttagtgatga gaatgtgata gcatagcata     1500

gccaactttc ctcaactcat aggacaagtg actacaagag gcaatgggta gtcccctgca     1560

ttgcactgtc tcagctttag aattgttatt tctgctatcg tgttataaga ctctaaaact     1620

tagcgaattc acttttcagg aagcatattc ccctttagcc caaggtgagc agagtgaagc     1680

tacaacagat ctttccttta ccagcacact tttttttttt ttcctgcctg aatcagggag     1740

atccaggatg ctgttcaggc cttatcccaa ccaaattccc ctcttcactt tgcagggccc     1800

atcttagtca aatgtgctaa cttctaaaat aataaatagc actaattcaa aatttttgga     1860

ctcttaaatt agctacttgc aggttcttgt tgaaaggtat ataatattac attgtaaaca     1920

aatttaaaat atttatggat atttgtgaaa agctgcatta tgttaaataa tattacatgt     1980

aaagctattt aaaagaggtt ttttttgtat tttgtttaac aaaaattgct caggagcatg     2040

ctaagcctga ggccaagttg tttcttagta tgacttttta aaaaaacatc tgctgagtag     2100

ctacagggcc aaagacttgg agagcttgtt tctgttgcat ttgcatatct tctcaggaaa     2160

ttaaagtgtg tcatacatat gtgtgtgtgt gtgtgtgtgt gtgtgtatat gtgtgtgtgt     2220

atatatatgt atacttataa aatcttggtg ttcttgatct ttgttgtgtt ataagcaatg     2280

tgtgctggag tgggctggtg ctagcttata agcacatatt attaaatttt caggaatgtt     2340

gcactttagt tattaactat aggcattctt gaaattggct atggtgggag tatttatacc     2400

atgtaaattg gcaaacacta cacattttcc ttttggacag ctagttcacc agcacaccac     2460

tgtgaaactc tccttaatga ctcctctctg cccccgcttc attcctggga taatcatagc     2520

agactaaggg agaaaatgaa attgtaaaaa tttggcatac tggtgatttc tcagggcaag     2580

cagaggttac tacagctgca gctagaggga tgactaccaa caggtgacct ttacattttc     2640

ctgatgttat aattttagct tttgttttca atgtatactg ttttcctgtt tctccacata     2700

gtagtctgca ttttaaatct ataataaaac atgctgataa ctgg                      2744


<210> 122
<211> 177
<212> PRT
<213> Homo sapiens

<400> 122
Met Cys Leu Ser His Leu Glu Asn Met Pro Leu Ser His Ser Arg Thr 
1               5                   10                  15      


Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu Trp Leu Phe Cys Ser Ile 
            20                  25                  30          


Val Met Leu Leu Phe Leu Cys Ser Phe Ser Trp Leu Ile Phe Ile Phe 
        35                  40                  45              


Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro 
    50                  55                  60                  


Leu Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn 
65                  70                  75                  80  


Lys Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu 
                85                  90                  95      


Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro 
            100                 105                 110         


Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr 
        115                 120                 125             


Asn Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val 
    130                 135                 140                 


Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys 
145                 150                 155                 160 


Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile 
                165                 170                 175     


Ser 
    


<210> 123
<211> 2064
<212> DNA
<213> Mus musculus

<400> 123
ttgtgggtat ctgctttccc cagttctcat tccatcagag aacgagttct agcctcatgg       60

aggaaatgcc tttgagagaa tcaagtcctc aaagggcaga gaggtgcaag aagtcatggc      120

tcttgtgcat agtggctctg ttactgatgt tgctctgttc tttgggtaca ctgatctata      180

cttcactcaa gccaactgcc atcgagtcct gcatggttaa gtttgaacta tcatcctcaa      240

aatggcacat gacatctccc aaacctcact gtgtgaatac gacatctgat gggaagctga      300

agatactgca gagtggcaca tatttaatct acggccaagt gattcctgtg gataagaaat      360

acataaaaga caatgccccc ttcgtagtac agatatataa aaagaatgat gtcctacaaa      420

ctctaatgaa tgattttcaa atcttgccta taggaggggt ttatgaactg catgctggag      480

ataacatata tctgaagttc aactctaaag accatattca gaaaactaac acatactggg      540

ggatcatctt aatgcctgat ctaccattca tctcttagag attgggtttg gtctcctcat      600

cttcttcttt gtatcccgag atgctggtgg gtgggttgga gggggatgat tgatggcaat      660

gcacacagtt tgtgagggct tacaaattga cacaatcaga gcctcttggc atataaaatt      720

ttagccctca tatctgtctg aagaggactc agcaaatggg ccaatcccta atgttgggtc      780

tgcaaatgga cttgtacaat ccatgataaa aaggagtatg ggccacagaa gacagaaact      840

cttccaaaga atgtctttct aaccttgatc cctgggtaga atgagatcct gtttccatgg      900

gagtcttact tggcttgcaa aaaagggtgt agggcagtag cttggccttt tttccatcat      960

aatttccttg agctgtttta ccttaatccc tccaaactct caccttctga gagcctccta     1020

atgaaacatt gttagactgg tggggtggcc aagacatgcc aacaacaccc ttctttagag     1080

gtggtgtttt tagaggacag agaacattat gaagcctaga gcagcagagg tcaagatgcc     1140

acgaaatgga attgatctgg gaattttttt tttttttcat tctcaggatg caggttcatt     1200

ctgaactttc ccctaggcct tcattgcttt tgtgtgtatg tgtgcataaa ttctgcaaat     1260

agaaaaatga gagtttgcac cagtactcac tagatttaac accagaaagt ggtacttttc     1320

tggctgtatt atgccatgat agcacatttt ctgttggtgt tccctaactg acaagtataa     1380

cagttttcct aaaccacaca acaatgctat gatgttaatg gggtagatat ttttggaaaa     1440

aaattgcaca gtgagaacat gggtagatga accctaagac tcttacctca attcagaact     1500

cgcaaggagt taagtgagtg gggtcttcat tagaccattc acatggtctc tgctttgaaa     1560

ctggcgttgc tactgtctca ttatacatca ctaaaatgga attaactcaa ctttgaaatg     1620

gatgcatcga ctttacccca aggtgtccag aatgaagcta caagactttt accagcagtc     1680

attttccttt tgcctggagc aagaagatcc aggatactgt tggaagagtt catctcactc     1740

aaccatgctg actttccaaa gtaataatga acatttgtgt tcaaattttg gattctgtta     1800

aatttagcca gcttgtgagt tcttgtcgaa aagtatttta aaccaattta cactatttat     1860

gggtatttgt gaaaagctat atagtgatat tttatatata actaatttaa aatattttta     1920

ttttatgtaa caaaaatact ataggctaag ctatttcttc ttattttttt atgaatactt     1980

gctgaattgc catagggcac aaagactctt ctgtttgcat atcttctcag gaaattaaaa     2040

ttgtatcaca tgtatttata agaa                                            2064


<210> 124
<211> 173
<212> PRT
<213> Mus musculus

<400> 124
Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      


Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          


Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              


Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  


Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      


Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         


Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             


Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr 
145                 150                 155                 160 


Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
                165                 170             


<210> 125
<211> 1852
<212> DNA
<213> Homo sapiens

<400> 125
aatcctgagt aaggtggcca ctttgacagt cttctcatgc tgcctctgcc accttctctg       60

ccagaagata ccatttcaac tttaacacag catgatcgaa acatacaacc aaacttctcc      120

ccgatctgcg gccactggac tgcccatcag catgaaaatt tttatgtatt tacttactgt      180

ttttcttatc acccagatga ttgggtcagc actttttgct gtgtatcttc atagaaggtt      240

ggacaagata gaagatgaaa ggaatcttca tgaagatttt gtattcatga aaacgataca      300

gagatgcaac acaggagaaa gatccttatc cttactgaac tgtgaggaga ttaaaagcca      360

gtttgaaggc tttgtgaagg atataatgtt aaacaaagag gagacgaaga aagaaaacag      420

ctttgaaatg caaaaaggtg atcagaatcc tcaaattgcg gcacatgtca taagtgaggc      480

cagcagtaaa acaacatctg tgttacagtg ggctgaaaaa ggatactaca ccatgagcaa      540

caacttggta accctggaaa atgggaaaca gctgaccgtt aaaagacaag gactctatta      600

tatctatgcc caagtcacct tctgttccaa tcgggaagct tcgagtcaag ctccatttat      660

agccagcctc tgcctaaagt cccccggtag attcgagaga atcttactca gagctgcaaa      720

tacccacagt tccgccaaac cttgcgggca acaatccatt cacttgggag gagtatttga      780

attgcaacca ggtgcttcgg tgtttgtcaa tgtgactgat ccaagccaag tgagccatgg      840

cactggcttc acgtcctttg gcttactcaa actctgaaca gtgtcacctt gcaggctgtg      900

gtggagctga cgctgggagt cttcataata cagcacagcg gttaagccca ccccctgtta      960

actgcctatt tataacccta ggatcctcct tatggagaac tatttattat acactccaag     1020

gcatgtagaa ctgtaataag tgaattacag gtcacatgaa accaaaacgg gccctgctcc     1080

ataagagctt atatatctga agcagcaacc ccactgatgc agacatccag agagtcctat     1140

gaaaagacaa ggccattatg cacaggttga attctgagta aacagcagat aacttgccaa     1200

gttcagtttt gtttctttgc gtgcagtgtc tttccatgga taatgcattt gatttatcag     1260

tgaagatgca gaagggaaat ggggagcctc agctcacatt cagttatggt tgactctggg     1320

ttcctatggc cttgttggag ggggccaggc tctagaacgt ctaacacagt ggagaaccga     1380

aacccccccc ccccccccgc caccctctcg gacagttatt cattctcttt caatctctct     1440

ctctccatct ctctctttca gtctctctct ctcaacctct ttcttccaat ctctctttct     1500

caatctctct gtttcccttt gtcagtctct tccctccccc agtctctctt ctcaatcccc     1560

ctttctaaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca     1620

gagtcaggcc gttgctagtc agttctcttc tttccaccct gtccctatct ctaccactat     1680

agatgagggt gaggagtagg gagtgcagcc ctgagcctgc ccactcctca ttacgaaatg     1740

actgtattta aaggaaatct attgtatcta cctgcagtct ccattgtttc cagagtgaac     1800

ttgtaattat cttgttattt attttttgaa taataaagac ctcttaacat ta             1852


<210> 126
<211> 261
<212> PRT
<213> Homo sapiens

<400> 126
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 127
<211> 1250
<212> DNA
<213> Mus musculus

<400> 127
ctttcagtca gcatgataga aacatacagc caaccttccc ccagatccgt ggcaactgga       60

cttccagcga gcatgaagat ttttatgtat ttacttactg ttttccttat cacccaaatg      120

attggatctg tgctttttgc tgtgtatctt catagaagat tggataaggt cgaagaggaa      180

gtaaaccttc atgaagattt tgtattcata aaaaagctaa agagatgcaa caaaggagaa      240

ggatctttat ccttgctgaa ctgtgaggag atgagaaggc aatttgaaga ccttgtcaag      300

gatataacgt taaacaaaga agagaaaaaa gaaaacagct ttgaaatgca aagaggtgat      360

gaggatcctc aaattgcagc acacgttgta agcgaagcca acagtaatgc agcatccgtt      420

ctacagtggg ccaagaaagg atattatacc atgaaaagca acttggtaat gcttgaaaat      480

gggaaacagc tgacggttaa aagagaagga ctctattatg tctacactca agtcaccttc      540

tgctctaatc gggagccttc gagtcaacgc ccattcatcg tcggcctctg gctgaagccc      600

agcagtggat ctgagagaat cttactcaag gcggcaaata cccacagttc ctcccagctt      660

tgcgagcagc agtctgttca cttgggcgga gtgtttgaat tacaagctgg tgcttctgtg      720

tttgtcaacg tgactgaagc aagccaagtg atccacagag ttggcttctc atcttttggc      780

ttactcaaac tctgaacagt gcgctgtcct aggctgcagc agggctgatg ctggcagtct      840

tccctataca gcaagtcagt taggacctgc cctgtgttga actgcctatt tataacccta      900

ggatcctcct catggagaac tatttattat gtacccccaa ggcacataga gctggaataa      960

gagaattaca gggcaggcaa aaatcccaag ggaccctgct ccctaagaac ttacaatctg     1020

aaacagcaac cccactgatt cagacaacca gaaaagacaa agccataata cacagatgac     1080

agagctctga tgaaacaaca gataactaat gagcacagtt ttgttgtttt atgggtgtgt     1140

cgttcaatgg acagtgtact tgacttacca gggaagatgc agaagggcaa ctgtgagcct     1200

cagctcacaa tctgttatgg ttgacctggg ctccctgcgg ccctagtagg                1250


<210> 128
<211> 260
<212> PRT
<213> Mus musculus

<400> 128
Met Ile Glu Thr Tyr Ser Gln Pro Ser Pro Arg Ser Val Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ala Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Val Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Val Glu Glu Glu Val Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys Gly Glu Gly Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Met Arg Arg Gln Phe Glu Asp Leu Val Lys 
                85                  90                  95      


Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys Glu Asn Ser Phe Glu Met 
            100                 105                 110         


Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser Glu 
        115                 120                 125             


Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr 
    130                 135                 140                 


Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln Leu 
145                 150                 155                 160 


Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe 
                165                 170                 175     


Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly Leu 
            180                 185                 190         


Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala 
        195                 200                 205             


Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His Leu 
    210                 215                 220                 


Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn Val 
225                 230                 235                 240 


Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe Gly 
                245                 250                 255     


Leu Leu Lys Leu 
            260 


<210> 129
<211> 4778
<212> DNA
<213> Homo sapiens

<400> 129
cgagactcca tctcaaaaac aaaacaaata aacgaacaaa aaaacccaca acgtattatt       60

ttcttgttta cgaggtttct tgtctctctg gctccaccag aagaggagca gggacccttc      120

ttgctgttgt tcattgctgc atcccccaca ccgagagcag agcctggcat gggcagaaag      180

tcctcagtcg atatttggtg gccccaagcg aatgaagcat ccaagaaggg aaagctgggg      240

gctccccact gcacttgcca cctgagtcac attttcagaa gcctctggaa agtcgtgcac      300

agcccaggag tgttgagcaa tttcggtttc ctctgaggtt gaaggaccca ggcgtgtcag      360

ccctgctcca gacaccttgg gcatggagga gagtgtcgta cggccctcag tgtttgtggt      420

ggatggacag accgacatcc cattcacgag gctgggacga agccaccgga gacagtcgtg      480

cagtgtggcc cgggtgggtc tgggtctctt gctgttgctg atgggggccg ggctggccgt      540

ccaaggctgg ttcctcctgc agctgcactg gcgtctagga gagatggtca cccgcctgcc      600

tgacggacct gcaggctcct gggagcagct gatacaagag cgaaggtctc acgaggtcaa      660

cccagcagcg catctcacag gggccaactc cagcttgacc ggcagcgggg ggccgctgtt      720

atgggagact cagctgggcc tggccttcct gaggggcctc agctaccacg atggggccct      780

tgtggtcacc aaagctggct actactacat ctactccaag gtgcagctgg gcggtgtggg      840

ctgcccgctg ggcctggcca gcaccatcac ccacggcctc tacaagcgca caccccgcta      900

ccccgaggag ctggagctgt tggtcagcca gcagtcaccc tgcggacggg ccaccagcag      960

ctcccgggtc tggtgggaca gcagcttcct gggtggtgtg gtacacctgg aggctgggga     1020

gaaggtggtc gtccgtgtgc tggatgaacg cctggttcga ctgcgtgatg gtacccggtc     1080

ttacttcggg gctttcatgg tgtgaaggaa ggagcgtggt gcattggaca tgggtctgac     1140

acgtggagaa ctcagagggt gcctcagggg aaagaaaact cacgaagcag aggctgggcg     1200

tggtggctct cgcctgtaat cccagcactt tgggaggcca aggcaggcgg atcacctgag     1260

gtcaggagtt cgagaccagc ctggctaaca tggcaaaacc ccatctctac taaaaataca     1320

aaaattagcc ggacgtggtg gtgcctgcct gtaatccagc tactcaggag gctgaggcag     1380

gataattttg cttaaacccg ggaggcggag gttgcagtga gccgagatca caccactgca     1440

ctccaacctg ggaaacgcag tgagactgtg cctcaaaaaa aagaaaggaa gaaaaaagaa     1500

aactcaggaa acagatcttg ggggacactc cagggaaccc aaaactcaaa ggcggagagc     1560

tcagtgggca ccaccaaggc gagatgaagc cccagcaggc accttcagaa gacccacgta     1620

gactgcagac cctgccacgg acaatactaa ggacaaaaac ccagagactt ggggtctgtg     1680

ggcccccaaa catggggtaa agttgatttg cctgatattc aggaagaagg ggtgaggggt     1740

gggtatttat gcttttgatt cagaagaaag tggggcttgg gattccaggg acttggctgg     1800

gggtgggaaa cttcatccac ttccctactc tcatcatgag tacggacagg gtgggcggga     1860

gactgatcat cgggactcat catgaagagc ccagccccac cccacatact cagatcccac     1920

ccacagactg gtggccacac ctcagcctgg tcacaaagag ttacactcag atacatgagc     1980

acggcagcgt gctcataact gtttaacaac cagctgtcct gggaggggga cagctttgta     2040

atgtttgcca atttccatgg tgtaaatgct accaccatgg ctgatttcat cactgccaag     2100

catagacatc cctaatagga caccacggat ctgtccccgg catccggccc agggcctggc     2160

acaaagcatg ctctagggaa atgcttgctg attgaaagga aggaagaatg actctacagt     2220

cacacctatg gcatcccaca aaatctgtca catggctgca taatctcagc cactctttca     2280

caactataga ctcatacacg cgaagtgcca gattcatgca caaccacaca atcacatgga     2340

agtcacagac ggcatcacag acagtcacag cactgtgtgt atgttataac acaagcacac     2400

aaaactcaga cagcatccca gctacacagc cactcccaga ggtgtcaccg tcacacttgg     2460

taattaatac tcattacatt agacacagac agaccaagtt atagtcagac ctggttacac     2520

acatacacac acacaatatc accatgacaa atacacatta cacacacaca acatcacaat     2580

gacaaacaca cattacacac acaacatcac gatgacaaac acacattaca cacacaacat     2640

cacgatgaca aacacacatt acacacacat cacaatgaca aacacaacat tacacacaca     2700

caacatcaca atgacacaca catcacacac acatcacaat gacaaacaca caacattaca     2760

cacatataca cacagcctga gggccctccc cagcccagac taacacatct cggggtgagg     2820

accagacctt gttcataacc ctgggcctct taaccactga tctttgaaat aaatggcaaa     2880

tagttgtacc tggatctgtc tagttcttag gggaacaaac tgaagaaggg tggagaggaa     2940

ttgtcaggcc taaagagccc cacagggaaa gggaggagtc ggatgggggg caaccatcag     3000

caacaagtgg tggctcctag aggcagaggg atggaggtaa tgacccatgg aggtcattct     3060

acagatgagg aacctggacc cagttggctc aagtccatgc aggaaatgtg ggggaaacca     3120

gagacctcac gtctggatct ggcttcctct ccaatccaca attcctgagg aagtagaggc     3180

tacatcccgc aagacgccct tattagacac atccaggaca gaatgacaat ccgccaagcc     3240

agctggaagc ataaaacaca gggagctggt gggttgggtg ggggcagata atgatatgca     3300

tacaaattag agggtctatg caaatgagca ttgctgcagt gtggctggag ggaatcctta     3360

gttcctagga ttctaggata tgggtttcga ccccagaggt gaatgtattg ttattattgt     3420

tttgttgttg ttgtgaatga caagtcaaaa tttgtgggtt attgttgtta tcgccaatag     3480

tattcttgtc attgttgcac agtacagaga tgaaggaaac agattttgca atcagatgat     3540

cctgggttct gagtccactc tgccactcac cagctatatg acctccagca atttccatca     3600

cctctcaatg cttcagtttc cccatcggca agatggttgt ggggggagag gaacaacagt     3660

acagattcac catcccaaat tcaaaatgct ccaaaatcta ggccgggcgt ggtggctcat     3720

acctgtaatc ccagcacttt gggaggtcaa agtggacgga taacctgagg tcaggagctc     3780

cagaccagcc tggccaacat ggcgaaaccc catctctact aaaaatacaa aaaattacct     3840

gggtgtggtg gggggcacct gtaaccccag ctactcggga ggctgaggca ggaaccctgg     3900

aggttgaggt tgcagtgagc tgagatcaca ccactgcact ccagcctggg tgacagagca     3960

aggctcccat ctcaaaaaac aaaaaaacat gctccaaaat ctgaaactct ttgagcccca     4020

gtgtgatgcc acaagtggga aattccacaa ctcatcacat gtgatagatt gcagtggaaa     4080

tgcaggcaca caccacgaag tttactcagc atcctcaaag gaaatccccg tcagtagcta     4140

tatatcattt tctcacatgc cagataggta tctctcatct tttactgtta ggtacttctg     4200

tgttgaatag gtggaggaaa atgattgctg gttagtagta tataaattca gagtcaggaa     4260

ggatggtgat gtcggctggg tgcagtggct catgcctgta attccaatgt gataccctac     4320

cttgtgttta acgtgattga ctctccctta gctgagaggg ccaggcagac tctattttgg     4380

cttcttcgct tgcagtctct cacccacccc ccttcctcaa ggacttaagc tgactcccag     4440

cacatccaag aatgcgatta ctgataagat actgtgacaa gctatatcca caattcccag     4500

gaattcgtcc ggttgatagc acccaaagcc cccgcgtcta tcaccttgtg atagatttaa     4560

agcccctgca cctggaactg tttgtttttc tgttaccatt tatctttttc actttcttgc     4620

ctgttttgct tctgtaaaat tgcttcagct cggctccctc ttccccttct aaaccaaggt     4680

ataaaaagaa acctagcccc ttctttgggg tggagagaat tttgagcgct agccgtctct     4740

cagtcgccgg ctaataaagg actcctgaat tagtctaa                             4778


<210> 130
<211> 240
<212> PRT
<213> Homo sapiens

<400> 130
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210> 131
<211> 1869
<212> DNA
<213> Mus musculus

<400> 131
ttttgcagtt tgcacagccc gagcgtgttg ggcaattgtg gtttcctccg gagaggagga       60

actcaggctt gccaaccctt tccctgggct tcggagcctc agctgctctg gcatggagag      120

tgtggtacag ccttcagtgt ttgtggtgga tggacagacg gacatcccat tcaggcggct      180

ggaacagaac caccggagac ggcgctgtgg cactgtccag gtcagcctgg ccctggtgct      240

gctgctaggt gctgggctgg ccactcaggg ctggtttctc ctgagactgc atcaacgtct      300

tggagacata gtagctcatc tgccagatgg aggcaaaggc tcctgggaga agctgataca      360

agatcaacga tctcaccagg ccaacccagc agcacatctt acaggagcca acgccagctt      420

gataggtatt ggtggacctc tgttatggga gacacgactt ggcctggcct tcttgagggg      480

cttgacgtat catgatgggg ccctggtgac catggagccc ggttactact atgtgtactc      540

caaagtgcag ctgagcggcg tgggctgccc ccaggggctg gccaatggcc tccccatcac      600

ccatggacta tacaagcgca catcccgcta cccgaaggag ttagaactgc tggtcagtcg      660

gcggtcaccc tgtggccggg ccaacagctc ccgagtctgg tgggacagca gcttcctggg      720

cggcgtggta catctggagg ctggggaaga ggtggtggtc cgcgtgcctg gaaaccgcct      780

ggtcagacca cgtgacggca ccaggtccta tttcggagct ttcatggtct gaaggctgcg      840

gtgacaatgt attttgtgga gggacctctc caggactcac ctcaaaccca gcaatagggt      900

ttgaagtcct ccctttaagg agccctgaac tctgcagtgc tcggggcggt gtagactgct      960

gacctgcttt gggcaatctt caaatcagag acctggagac ttggggcgtg gagcccagga     1020

gcgaggggtc agctcatttg cctgatattc aggaagaaag aatcaagctg gggtatttat     1080

gcttctgatg caaacactga gatttcggct ttctgggttt tgagctggag gcaagaaacc     1140

ttcccagagt gtcatcagga ccatgttggc aggacttggg gctccagact tgccaccaca     1200

ctctggcctc tcccatccat ccgctgcatt ggtttccagc caccaaaaca gcactggccc     1260

cctggctgca actggccagg tacgagcttc tgagcaccta cattcctcag ggacatcttg     1320

atgagatctc agtactcagt ccaatgcgca gcagcgacag acatgccagg aatggttggt     1380

cagaagggaa gggaggaaag ggaggaaaga agggaatgca gaagagaagg ggggaaaaca     1440

agaccaaaac aaaacagcaa caacaaagcg gcagggagga ggtgacaccc ttggggatac     1500

tttagtcaac acacttagaa cagattgtgc caggcctgtt ggattcctgg agttgatggg     1560

atcgtgggaa ggcacaatgg ggagcaagtg ggcttgggtt atggctcagt gggtaaagtg     1620

caattatggg gatctgagtt tgaatccctg gtacccatat aaagacacag atgcggtgat     1680

gggcacttgt gacaatgaga tcatcaatag ggaatggaga caggagggac ctctggggtt     1740

cactggccag gcagtctagc tgaatcaaag agctccaagt tcagtcgata gctcctgaag     1800

atgacaactg aggctattct ccaaacccca cacgcaggac acatgcgtaa taaataaaat     1860

tttaaaaat                                                             1869


<210> 132
<211> 239
<212> PRT
<213> Mus musculus

<400> 132
Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210> 133
<211> 6583
<212> DNA
<213> Homo sapiens

<400> 133
agaggtgcct ccaggagcag caggagcatg gccgaggatc tgggactgag ctttggggaa       60

acagccagtg tggaaatgct gccagagcac ggcagctgca ggcccaaggc caggagcagc      120

agcgcacgct gggctctcac ctgctgcctg gtgttgctcc ccttccttgc aggactcacc      180

acatacctgc ttgtcagcca gctccgggcc cagggagagg cctgtgtgca gttccaggct      240

ctaaaaggac aggagtttgc accttcacat cagcaagttt atgcacctct tagagcagac      300

ggagataagc caagggcaca cctgacagtt gtgagacaaa ctcccacaca gcactttaaa      360

aatcagttcc cagctctgca ctgggaacat gaactaggcc tggccttcac caagaaccga      420

atgaactata ccaacaaatt cctgctgatc ccagagtcgg gagactactt catttactcc      480

caggtcacat tccgtgggat gacctctgag tgcagtgaaa tcagacaagc aggccgacca      540

aacaagccag actccatcac tgtggtcatc accaaggtaa cagacagcta ccctgagcca      600

acccagctcc tcatggggac caagtctgta tgcgaagtag gtagcaactg gttccagccc      660

atctacctcg gagccatgtt ctccttgcaa gaaggggaca agctaatggt gaacgtcagt      720

gacatctctt tggtggatta cacaaaagaa gataaaacct tctttggagc cttcttacta      780

taggaggaga gcaaatatca ttatatgaaa gtcctctgcc accgagttcc taattttctt      840

tgttcaaatg taattataac caggggtttt cttggggccg ggagtagggg gcattccaca      900

gggacaacgg tttagctatg aaatttgggg cccaaaattt cacacttcat gtgccttact      960

gatgagagta ctaactggaa aaaggctgaa gagagcaaat atattattaa gatgggttgg     1020

aggattggcg agtttctaaa tattaagaca ctgatcacta aatgaatgga tgatctactc     1080

gggtcaggat tgaaagagaa atatttcaac accttcctgc tatacaatgg tcaccagtgg     1140

tccagttatt gttcaatttg atcataaatt tgcttcaatt caggagcttt gaaggaagtc     1200

caaggaaagc tctagaaaac agtataaact ttcagaggca aaatccttca ccaatttttc     1260

cacatacttt catgccttgc ctaaaaaaaa tgaaaagaga gttggtatgt ctcatgaatg     1320

ttcacacaga aggagttggt tttcatgtca tctacagcat atgagaaaag ctacctttct     1380

tttgattatg tacacagata tctaaataag gaagtatgag tttcacatgt atatcaaaaa     1440

tacaacagtt gcttgtattc agtagagttt tcttgcccac ctattttgtg ctgggttcta     1500

ccttaaccca gaagacacta tgaaaaacaa gacagactcc actcaaaatt tatatgaaca     1560

ccactagata cttcctgatc aaacatcagt caacatactc taaagaataa ctccaagtct     1620

tggccaggcg cagtggctca cacctgtaat cccaacactt tgggaggcca aggtgggtgg     1680

atcatctaag gccgggagtt caagaccagc ctgaccaacg tggagaaacc ccatctctac     1740

taaaaataca aaattagccg ggcgtggtag cgcatggctg taatcctggc tactcaggag     1800

gccgaggcag aagaattgct tgaactgggg aggcagaggt tgcggtgagc ccagatcgcg     1860

ccattgcact ccagcctggg taacaagagc aaaactctgt ccaaaaaaaa aaaaataaaa     1920

taataactcc aagcctttaa aaaatatcat ctgaaactgt tacatcagat ttctggcact     1980

ctactgactg tggaagatag ccagctgact ggaagatagc cagctgatta gttccctgaa     2040

gaaacctgaa gacagatacc tggttaacta gatcaactac actgccaact tgtttgatgc     2100

tgagagacaa tggacttatt ccatggggga agggaaaaaa gaagtcaatc accaaatctg     2160

aagaagttaa cctagatctt tgaggtttga tttgcaactt tatatgcaga gtattatgtg     2220

ggtattttcc cttaaaatat tcaaagggat ttacatatgg gattagctaa tgagcctagc     2280

caagaccttc cctggaggac aggctggtca ttgcggaggt cccttctgtg cttcagtggg     2340

ttcatatcct ctagtccgta tgattttcct acgctaatat gtcaagggca ggagaggcag     2400

ctctgttctc ctagcctttg ttgacttgtc tgcaaagcag gaatctgccc atttgtttcc     2460

aaggagcaaa tgagctcatg agaatgaaag atgttaactt catgcattct gtgccatctg     2520

agcatttcgg tattatatga ctggtgaccc ttggcccgta ttataaatgc ttcctatcct     2580

gggagacctc atggatgagt ctgagaggaa atttggcacc aaaatcactc tcactctggt     2640

ttccagtaga ctatagaggc agagaggcat ttgagaggct cctgagcaaa gtgtccagtg     2700

tagcaggagc acttcattaa tatttattga gttataatta aataaaaatt aatttctgat     2760

ttctcagttt ggaggttaag gctctaaata tattttctaa cctctgctag gctaacttaa     2820

gccaggcctt tttcttgcct tccctttctc aaaacagtca gcacagactc agtgggagca     2880

cagaggagtg tggtcacctc cacctggctc accagagtct tcatagagga agtgaagcct     2940

ggaagaaact gggcgggccc cagatgacca cagggaaagg gcatctcaga tggaggaatt     3000

acccttgact taaagcagaa aagaaagatt tctcagtaac tccaaaactt gcttgatagg     3060

agaatattcc ctcaaccaat tcctaggaca atatttattg gtagatcaag aatgtttcct     3120

caataactct agtctagctc catgatcaga actaacaccc attaaaaaca taaaatgttc     3180

tttctgaacc ggtcttcatg gtgcgtgaga gcaccaagca gctttggtat gcaggaggag     3240

ttttgcacag aagagtggcc tgctcaaacc tgcccactgt tctgtaggtg atctggtgga     3300

tctggaaatt tatcccaaga caggaatttc ctaatattcg aagacatttg aggctttggg     3360

aaattctctg ctgtgcattt atttggctcc tgtcataagc ttgtttttta aagaatgtat     3420

catagctcaa gtttttactg ctgattttgt taaattctgt atagtatatt ttttacggaa     3480

aggcacagtc agacattcct aatagggctc atgtcagaac ttctgttccc aaggcattat     3540

ctccatagca aaaattagtg cactgttttc aaaagtgagg tgggaaaatg cttttaagat     3600

catgtgatgt tcccctaaaa ggggttaatg gggtgtattc agggtttggg agggaggaag     3660

aagcatgctt tagaaaacag taaatttagg gagaaaatgc tttgttggtt aaatgtcact     3720

caaaaggctg aattcaaatc aattccacaa acatttactg agtacctact gcccctgggg     3780

acacagagat aaattattta gtctcagaca cactcattct aacttcccag cacctctact     3840

gtctgcagat tctttaattt attttggttg tattagctaa ttaattcgta aactttaggc     3900

acatggatct attctcatta tgaaaatgga tgccatttga ttaaggctga tgactaacaa     3960

aatgatttgt gtttactcga agtgtttttt taaaaatagc tactcaagga tagttttcca     4020

taaatcaaga aggtaaaaaa gttcccattt tttattgtag aatccattat ttaaactaca     4080

tgtagagaca ggttattatt tgctatattc aagtttggtc atcaataccc ttaaaaatat     4140

tagaatttta tggatgaccc agaaatgctt tgaaaatctg tgttcctcag caaatacaga     4200

gaccatgatc aaaatgcaca gaatcactaa cattttgatg ctagcatggt ttcagtctat     4260

ttggcagaac agaattgatt atgctactaa aatttctttt tctttttttt tttttttttt     4320

tttgagacag agtcttgctt tgtcacccag gctgaagtgc agtggcagga tctcagttca     4380

ctgcaacctc tgcctcccag gttcacgcca ttctcctgct tcagcctccc gagtagctgg     4440

gactacaggc tcccaccacc atgcccggct aattttttgc atttttagta gagacggggt     4500

ttcaccgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccgcc cgcctcagcc     4560

ttccaaagtg ctgggattac aggcgtgagc cactgtgccc ggactctgat ttttttttta     4620

ctaaggtaca gtaagaaaag ggaaaagtgt acgttttcac ttcctgaaat atgtcaggtt     4680

gaatcaataa tagagcacac cagaactctt ggctccattt caacctaaac tattcagttc     4740

tcatcacccc agaggaaatt ccgcctctgt gctggtcagt aatccccctg gattataaaa     4800

gtttaactaa ctcactgtgc acaaggcacg gccattgcca acattctctt gcaaggtatt     4860

ttcccaagcc cttacccaat tctgtttcca tgattgtgac attggggatt aattctgcaa     4920

gacagaactg tttatattct gtaccttaaa aacacatgca aacatctctt gccttaagat     4980

ttctggcttt cctatggccc agagtcctag aagtgttttg atatttgtag cagaattttc     5040

aagtgtacat ccttatcctg gatattaaca tttttgcatc atattggcag ctggacctac     5100

agagaattta gtagactgtt aacctaataa gccttgaatc cttttgcacc agtggtgaga     5160

gaatgtggat cagagccatc acctccatgc cccgtcaccc tctaacaacc acatttacaa     5220

cttccccagc tctgagacac acttgcctcc accccttcca tcaccccatt ttaagatgaa     5280

aataccacac cagcctggaa ggaagaagtt acttgcccag ggccacatag tgagttaagg     5340

gctgatctag agctaggaag ctgtcttcct gaaccataat cctggactct tctaacctct     5400

ctactcatcg caaatagagt tcattttagt gatttgaagg aagatgggac aagtattttc     5460

aaacacctgt aggacaacat ggaagtggga ggagacttct actgtagctc cccagagaag     5520

agagctaggg ctacagagtt gcagttacaa ggttgccctc tctggcttga tccccaaagg     5580

aattttctac tccaaaatag aatttttcta ggatgctatt tctcagtccc tggagatact     5640

caaacaaagg gcttgtcaca agggtttttg tagaagctat tcttcacaga ggttggggga     5700

gagattaagc caaaggatct ctgaggtctt tttcaaatct ataattatgt ggccttttgt     5760

tcattgactt ccatgtgttc tagttgatca ttacaaacct ggcaggcctt ctcaagggtt     5820

cagtaattag ctgtcatttc ccatttgtcc agagagtgtc caacacaaaa tacccctaag     5880

atcttggcca atagagaaat gtcatggaat tttagaaatg acagtatctg cggagtttat     5940

tccaagttat atcatttcaa agatgaagaa acccaggctc agagggagcc atcacatcca     6000

caccctgtca cccttcgtgg ccagtgccag acagtagcta gttggatgct aaaagtagaa     6060

tttagatatc ttaacaataa gcccagcagt ctttcaactt cattcgtaaa tcatttttgt     6120

tttgagcatc tgtcacgtgg cagcacttgc ctggatactg gagagctgag aaggaatgcg     6180

acaggcaagt cctactctca cagtgtatac attcaggagg aacaagacac acagtgccaa     6240

gtaaataaag tagctgaact tcatcaaatg attttattct taaagtcatt aaagcatgta     6300

atgttcccct ttttttgttt caggggtgta cagattgaag aagtgtaggt gtttatgtgg     6360

ttttagtgac aaaccccatg tgctttcatt gattttatgt tttatgttaa aacatcaacc     6420

gcaaggtaaa atgcatattg tatgttgttg gatacgtact taactggtat gcatcccatg     6480

tctttgggta ctagtgtatg aattctaatc tctgtaaatg aaatgttgta tgtgttaata     6540

tatttaatag atgtaactta ataaactggc attgaagact gaa                       6583


<210> 134
<211> 251
<212> PRT
<213> Homo sapiens

<400> 134
Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210> 135
<211> 5777
<212> DNA
<213> Mus musculus

<400> 135
atcagaagtc tctccaagac agcagaagga tggcagagga gctggggttg ggcttcggag       60

aaggagtccc agtggaagtg ctgccggaag gctgtagaca caggccagag gccagggccg      120

ggctagctgc caggagcaaa gcctgcctgg ctctcacctg ctgcctgttg tcatttccca      180

tcctcgcagg acttagcacc ctcctaatgg ctggccagct ccgggtcccc ggaaaagact      240

gtatgcttcg ggccataaca gaagagagat ctgagccttc accacagcaa gtttactcac      300

ctcccagagg caagccgaga gcacacctga caattaagaa acaaacccca gcaccacatc      360

tgaaaaatca gctctctgct ctacactggg aacatgacct agggatggcc ttcaccaaga      420

acgggatgaa gtacatcaac aaatccctgg tgatcccaga gtcaggagac tatttcatct      480

actcccagat cacattccga gggaccacat ctgtgtgtgg tgacatcagt cgggggagac      540

gaccaaacaa gccagactcc atcaccatgg ttatcaccaa ggtagcagac agctaccctg      600

agcctgcccg cctactaaca gggtccaagt ctgtgtgtga aataagcaac aactggttcc      660

agtccctcta ccttggggcc acgttctcct tggaagaagg agacagacta atggtaaacg      720

tcagtgacat ctccttggtg gattacacaa aagaagataa aactttcttt ggagctttct      780

tgctataagg aggagaaaac catcattcca aggggctccc ctgcctccta ctttccaatt      840

tccttttctc atatggatct ataaacaggg gctttagagg gatcagggaa ggggacagtg      900

gtttagctat ataatttagg aacccaatat tgatccgtat atgccttatg gactaaaata      960

gtaaatggaa aacccagtac agctcatgtt tgatagagac ctgctgggtt ttaaaaattg     1020

aaacacgcct catccaatgg cacaatctac tgatttcagg acagaacctt tccacagtgc     1080

cctctgtcca agtcctttct gaattcagca gttcagttag agctgaattc gacaatgaac     1140

ttactccaga tcaagagcta aagacagaat ccaaagaaag actgagaaaa tgatgttatt     1200

tctccaagag gcaatgcatt tccacattct tttgtgccta acctaaaaaa taagaaagaa     1260

gaaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa     1320

ggaaggaagg aagggacaag aaaagacaag acaagacaag aaaaaagaaa aaatggtatt     1380

tctcgtgaat attccctaaa aggaattggt tttctgctgt gaaggagaaa cctcaccttt     1440

cttctgattg catcctttag tatccaaaca tacaagtggg aattccaaat gcacatggaa     1500

catagaacac ttttattatt gtgagaacat gtttattgag tacctactat gctctgggca     1560

ctcagcccac aggaccatga agagaaagtc aaattttctt aaaaactaaa tgaatcctca     1620

atacatactt cctgatcaac taccactcaa aatgtataac ttccaaagta taacttcaag     1680

tcagccatct aggtggtttc ttgggtaaag gtgcttgtca ttaagcctga cacctgggtt     1740

tgacctccca gaacccaaaa gctggaagga gagaattggt tcccacaaat tatcctcaaa     1800

cccccataca aatgatgtgg catgcacaca tgtaactaaa taaataagtg taaaacaaaa     1860

acaaaaacaa aattttaaag aaaaatttca agtcctgaaa gacagcattc ctgagaatgt     1920

tgtctccatc gttgtccagt ataggctaac cagctgatag agacactgaa ggaatttaaa     1980

gacagacatc aagtgaaatg gagcactgta gaaacacttg attcatgcca ggagtcaatg     2040

tactatgaag accaacaaca aagtgtcagt catcaaatcc agaggtgttt atctagatct     2100

gctttcaagt ttggtttgca gcctttatat agtctctatt acaaatgctc gtgtcatggt     2160

agatgccaca aggagtcaga gggtaaactt agccccaaac cactgctgag ccatcttcta     2220

ggaaaccttc gaagcagagc tgggcagcgt gactcccaca caatgactgg gaaagtagta     2280

gctgatcaaa atttgttgag taataatttg ttagaaaatt catctccact gcctactaaa     2340

cctaagttgt atactatcta gcttctgcta agccaactta cattggccac tttttctgtc     2400

ttcaacttct tgaagtatca caggtctcag tgagaacaca gggaaaggtg aggtcgcctt     2460

cccctggttc ttcatagggg aaaccacacc tgaaagaaga tgagcagcct gaggtgacct     2520

ggaggaaggg ctgtctcaga agaaggactt attttttggc ttaggtctaa aaccttgaga     2580

gtaatgctca ctggtcaatt gaggatgctt tatcaatgac tccagtctga ctccaaggtc     2640

agaaaggaga gtgagatgct ctctctgcct gcatatatct tcatggaaca tgagaatatt     2700

gagcaacata gacttatagg aaaacacttg cccaaaagta gccagagtga cctggtcatc     2760

ccctctacta aacccaagct ttgtgtcaag ggccttcaaa gctgcccaga agtgatctgg     2820

atggcttggg aatttatcca agacaggaat ttcctgacag ccaaagatgc ttgagtcctt     2880

gtgcctgaca tgcatttatt ttgcccctgt ttattgaaga ctgtaactgt tgatttgtgg     2940

gtatacatac atacatacat acatacatac atacatacat acatatgctg tcatgaaggc     3000

agcatcaaac attactaatt ggactcaaac cagcatttct gtttccaaga tactaagtat     3060

tcccatgcaa acaggagcat gctatttttc taaagcaaaa tgaaaaaaat agttttgaaa     3120

gtatatatat gatggagtca agtgtaatgg catacatctg taaacccagc acatgggatg     3180

ctgagccagg aggattgccg tgagtttgag gagaacaggg gctaaatagt aattttcagg     3240

aaagccttgc ctatataaca agaccttgtc tcaaatgaaa aaaaaaaaaa aaatagaccc     3300

caggctggtc cttggagata aggtaatata ttcattgggt gagggggtgt gtgttttgga     3360

aaatagttaa tttagtgaga aatgcttttc ggtcaaatgc atctcaaagg ctgctgaatt     3420

caaatcgggt ctgtaaatgc ttacctagtg cttgcttgcc ctggggacag agacataaat     3480

tactttagtc tcagatccac tcgttctaac agattggcat ctccatcgtc tgtggagctt     3540

ttaatcactc tgtttgtatt agctaattaa ttagctaact tgagacacac tgatattttc     3600

ttattataaa catgggtgcc atttgataaa agacaatcat taacaaaatg gttcgaattt     3660

ccgcttaagt gatcttcttt tttccttttc atttttttta actagctaat caaaggtagt     3720

ttcccaaaaa taaatgcaaa gggagtataa agaaaaaatt ccctgtggtg ggagctagta     3780

ttgaaacaac agtatcaaag aggctgttac ctactggcct caaattttgg caggaacgcc     3840

tttgaaaatg ttagaacttt acggacagcc tagaggtgct ttgaaaagtc tctgttgcca     3900

acaaaagcca ttaatcagca tgcggcacag gttactcaaa ttttgacctt gactgttttt     3960

tagatctgtt acacagaaca caacttctgg gctgtaatct ctgatgtgga tttggtgatt     4020

tactaaggta ccgtgggaaa caaggaaagt gtacttgtac cacatcgttt ctcagtgcat     4080

gtcagagtct actcaacagc agggcatgcc agagccttgg atacattccg ggacaaacta     4140

tgtcactcct aaggaaattc caagtgtgtg cctgtcaagc actctggatc atagaagccc     4200

acgagttcac tgtgcacaag gcacagccat ggccagcact ctcttgcatg gtatttctct     4260

taagctctta ctcaatcacg gtcccatgat tgtgacattg gggattaatt gcttgagcag     4320

gtttatttac agtctgttcc ttgcaaaata catgcagata tgtctggcct caaaatcccc     4380

tgattgtttt agggcttaga gaatactggg gatgtttttg ctgttttcag atgtacttta     4440

tttaagcttg cagaattacc ctgaatatta acagtgttct aagatattgc ctgctagctt     4500

ctggctaatt tactagtggt gacagtatca gatcagagta tctatattta tgtcttgcta     4560

ttatagttaa aacttcctga tctctgtaac acactcaccc ctacctcatc tatctaccca     4620

tcttgtggat gtagctgtga gaagactcac aagcccgagt tgcagttact tttctgaagc     4680

aacatagtat gttaatggaa tggccagaac tctactcttg gcacatggca ctgaatttga     4740

tgccactaaa agaaaaattg aaggcagaaa tattttttac tatgcatggg acaacgtaga     4800

agagcaagga gactgcttac acatggtggt cacatctctg gcttcatccc taaaccaatt     4860

ttctgacccc aagtcgattt tttttcatgt agttattgtt cattttctgg aaagagtcaa     4920

gcaaaaagag agttttatag aaaccattgc atcatggagg tcaggggagg gattaagcca     4980

aagaattcct tctccaaatc tatagccata tggccaccct ttggtgtact tctatttgat     5040

catgacaaac ctgagagccc tgcccagagt tcagtggatc ctaatgaact ccaagagtaa     5100

ttcattccct caccaactct aggggcttgg ccagtgcaga aaatgtcatg ggattttaaa     5160

gttaacatga gctgctatcc aaacttatgt ctctttaaga atggagagac acaggccagg     5220

agaggtaaca tatgaagcct ggtattgggc agtagcttga tggagtattg aggctaaaag     5280

tagacttcct gcccctgacc atacacaaca ccctttcagt ttgatccatg gtggtcttat     5340

tctactttat tttgagcacc tgtcacacct agttactgtc atgccaagaa ggtccataac     5400

aggcaaatcc tactctgctg tgtgcacaca agaggaagga ggctcacagt agcaagtaaa     5460

cagataagca aacgtacacg attttcgtct taaagtcatt aagacacacg cgtacccctc     5520

ttttgtttca gagggtatac aggctgaaca gatgtcagtg ttcacctatt cttattgata     5580

agccccatgt gctttcattg gttgaatgtt ttatgttaaa acgtcatatt gccatcgtaa     5640

aatgcatatt gtatgttgtt gggtatataa ttaactaata tgcatcgcat gtatgaattc     5700

taatctctgt aaatgaaaac ttatatatgt taacatatgt aatagttata atttaataaa     5760

ctgacactgg agactac                                                    5777


<210> 136
<211> 252
<212> PRT
<213> Mus musculus

<400> 136
Met Ala Glu Glu Leu Gly Leu Gly Phe Gly Glu Gly Val Pro Val Glu 
1               5                   10                  15      


Val Leu Pro Glu Gly Cys Arg His Arg Pro Glu Ala Arg Ala Gly Leu 
            20                  25                  30          


Ala Ala Arg Ser Lys Ala Cys Leu Ala Leu Thr Cys Cys Leu Leu Ser 
        35                  40                  45              


Phe Pro Ile Leu Ala Gly Leu Ser Thr Leu Leu Met Ala Gly Gln Leu 
    50                  55                  60                  


Arg Val Pro Gly Lys Asp Cys Met Leu Arg Ala Ile Thr Glu Glu Arg 
65                  70                  75                  80  


Ser Glu Pro Ser Pro Gln Gln Val Tyr Ser Pro Pro Arg Gly Lys Pro 
                85                  90                  95      


Arg Ala His Leu Thr Ile Lys Lys Gln Thr Pro Ala Pro His Leu Lys 
            100                 105                 110         


Asn Gln Leu Ser Ala Leu His Trp Glu His Asp Leu Gly Met Ala Phe 
        115                 120                 125             


Thr Lys Asn Gly Met Lys Tyr Ile Asn Lys Ser Leu Val Ile Pro Glu 
    130                 135                 140                 


Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Ile Thr Phe Arg Gly Thr Thr 
145                 150                 155                 160 


Ser Val Cys Gly Asp Ile Ser Arg Gly Arg Arg Pro Asn Lys Pro Asp 
                165                 170                 175     


Ser Ile Thr Met Val Ile Thr Lys Val Ala Asp Ser Tyr Pro Glu Pro 
            180                 185                 190         


Ala Arg Leu Leu Thr Gly Ser Lys Ser Val Cys Glu Ile Ser Asn Asn 
        195                 200                 205             


Trp Phe Gln Ser Leu Tyr Leu Gly Ala Thr Phe Ser Leu Glu Glu Gly 
    210                 215                 220                 


Asp Arg Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr 
225                 230                 235                 240 


Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250         


<210> 137
<211> 2737
<212> DNA
<213> Homo sapiens

<400> 137
aaaccctctg taaagtaaca gaagttagaa ggggaaatgt cgcctctctg aagattaccc       60

aaagaaaaag tgatttgtca ttgctttata gactgtaaga agagaacatc tcagaagtgg      120

agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga atttttcttc agcaagctgt      180

gaaactaaat ccacaacctt tggagaccca ggaacaccct ccaatctctg tgtgttttgt      240

aaacatcact ggagggtctt ctacgtgagc aattggattg tcatcagccc tgcctgtttt      300

gcacctggga agtgccctgg tcttacttgg gtccaaattg ttggctttca cttttgaccc      360

taagcatctg aagccatggg ccacacacgg aggcagggaa catcaccatc caagtgtcca      420

tacctcaatt tctttcagct cttggtgctg gctggtcttt ctcacttctg ttcaggtgtt      480

atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct      540

gttgaagagc tggcacaaac tcgcatctac tggcaaaagg agaagaaaat ggtgctgact      600

atgatgtctg gggacatgaa tatatggccc gagtacaaga accggaccat ctttgatatc      660

actaataacc tctccattgt gatcctggct ctgcgcccat ctgacgaggg cacatacgag      720

tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtgacg      780

ttatcagtca aagctgactt ccctacacct agtatatctg actttgaaat tccaacttct      840

aatattagaa ggataatttg ctcaacctct ggaggttttc cagagcctca cctctcctgg      900

ttggaaaatg gagaagaatt aaatgccatc aacacaacag tttcccaaga tcctgaaact      960

gagctctatg ctgttagcag caaactggat ttcaatatga caaccaacca cagcttcatg     1020

tgtctcatca agtatggaca tttaagagtg aatcagacct tcaactggaa tacaaccaag     1080

caagagcatt ttcctgataa cctgctccca tcctgggcca ttaccttaat ctcagtaaat     1140

ggaatttttg tgatatgctg cctgacctac tgctttgccc caagatgcag agagagaagg     1200

aggaatgaga gattgagaag ggaaagtgta cgccctgtat aacagtgtcc gcagaagcaa     1260

ggggctgaaa agatctgaag gtcccacctc catttgcaat tgacctcttc tgggaacttc     1320

ctcagatgga caagattacc ccaccttgcc ctttacgtat ctgctcttag gtgcttcttc     1380

acttcagttg ctttgcagga agtgtctaga ggaatatggt gggcacagaa gtagctctgg     1440

tgaccttgat caaggtgttt tgaaatgcag aattcttgag ttctggaagg gactttagag     1500

aataccagtg ttattaatga caaaggcact gaggcccagg gaggtgaccc gaattataaa     1560

ggccagcgcc agaacccaga tttcctaact ctggtgctct ttccctttat cagtttgact     1620

gtggcctgtt aactggtata tacatatata tgtcaggcaa agtgctgctg gaagtagaat     1680

ttgtccaata acaggtcaac ttcagagact atctgatttc ctaatgtcag agtagaagat     1740

tttatgctgc tgtttacaaa agcccaatgt aatgcatagg aagtatggca tgaacatctt     1800

taggagacta atggaaatat tattggtgtt tacccagtat tccatttttt tcattgtgtt     1860

ctctattgct gctctctcac tcccccatga ggtacagcag aaaggagaac tatccaaaac     1920

taatttcctc tgacatgtaa gacgaatgat ttaggtacgt caaagcagta gtcaaggagg     1980

aaagggatag tccaaagact taactggttc atattggact gataatctct ttaaatggct     2040

ttatgctagt ttgacctcat ttgtaaaata tttatgagaa agttctcatt taaaatgaga     2100

tcgttgttta cagtgtatgt actaagcagt aagctatctt caaatgtcta aggtagtaac     2160

tttccatagg gcctccttag atccctaaga tggctttttc tccttggtat ttctgggtct     2220

ttctgacatc agcagagaac tggaaagaca tagccaactg ctgttcatgt tactcatgac     2280

tcctttctct aaaactgcct tccacaattc actagaccag aagtggacgc aacttaagct     2340

gggataatca cattatcatc tgaaaatctg gagttgaaca gcaaaagaag acaacatttc     2400

tcaaatgcac atctcatggc agctaagcca catggctggg atttaaagcc tttagagcca     2460

gcccatggct ttagctacct cactatgctg cttcacaaac cttgctcctg tgtaaaacta     2520

tattctcagt gtagggcaga gaggtctaac accaacataa ggtactagca gtgtttcccg     2580

tattgacagg aatacttaac tcaataattc ttttcttttc catttagtaa cagttgtgat     2640

gactatgttt ctattctaag taattcctgt attctacagc agatactttg tcagcaatac     2700

taagggaaga aacaaagttg aaccgtttct ttaataa                              2737


<210> 138
<211> 288
<212> PRT
<213> Homo sapiens

<400> 138
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 139
<211> 1701
<212> DNA
<213> Mus musculus

<400> 139
gagttttata cctcaataga ctcttactag tttctctttt tcaggttgtg aaactcaacc       60

ttcaaagaca ctctgttcca tttctgtgga ctaataggat catctttagc atctgccggg      120

tggatgccat ccaggcttct ttttctacat ctctgtttct cgatttttgt gagcctagga      180

ggtgcctaag ctccattggc tctagattcc tggctttccc catcatgttc tccaaagcat      240

ctgaagctat ggcttgcaat tgtcagttga tgcaggatac accactcctc aagtttccat      300

gtccaaggct cattcttctc tttgtgctgc tgattcgtct ttcacaagtg tcttcagatg      360

ttgatgaaca actgtccaag tcagtgaaag ataaggtatt gctgccttgc cgttacaact      420

ctcctcatga agatgagtct gaagaccgaa tctactggca aaaacatgac aaagtggtgc      480

tgtctgtcat tgctgggaaa ctaaaagtgt ggcccgagta taagaaccgg actttatatg      540

acaacactac ctactctctt atcatcctgg gcctggtcct ttcagaccgg ggcacataca      600

gctgtgtcgt tcaaaagaag gaaagaggaa cgtatgaagt taaacacttg gctttagtaa      660

agttgtccat caaagctgac ttctctaccc ccaacataac tgagtctgga aacccatctg      720

cagacactaa aaggattacc tgctttgctt ccgggggttt cccaaagcct cgcttctctt      780

ggttggaaaa tggaagagaa ttacctggca tcaatacgac aatttcccag gatcctgaat      840

ctgaattgta caccattagt agccaactag atttcaatac gactcgcaac cacaccatta      900

agtgtctcat taaatatgga gatgctcacg tgtcagagga cttcacctgg gaaaaacccc      960

cagaagaccc tcctgatagc aagaacacac ttgtgctctt tggggcagga ttcggcgcag     1020

taataacagt cgtcgtcatc gttgtcatca tcaaatgctt ctgtaagcac agaagctgtt     1080

tcagaagaaa tgaggcaagc agagaaacaa acaacagcct taccttcggg cctgaagaag     1140

cattagctga acagaccgtc ttcctttagt tcttctctgt ccatgtggga tacatggtat     1200

tatgtggctc atgaggtaca atctttcttt cagcaccgtg ctagctgatc tttcggacaa     1260

cttgacacaa gatagagtta actgggaaga gaaagccttg aatgaggatt tctttccatc     1320

aggaagccta cgggcaagtt tgctgggcct ttgattgctt gatgactgaa gtggaaaggc     1380

tgagcccact gtgggtggtg ctagccctgg gcaggggcag gtgaccctgg gtggtataag     1440

aaaaagagct gtcactaaaa ggagaggtgc ctagtcttac tgcaacttga tatgtcatgt     1500

ttggttggtg tctgtgggag gcctgccctt ttctgaagag aagtggtggg agagtggatg     1560

gggtgggggc agaggaaaag tgggggagag ggcctgggag gagaggaggg agggggacgg     1620

ggtgggggtg gggaaaacta tggttgggat gtaaaaacga taataatata aatattaaat     1680

aaaaagagag tattgagcaa a                                               1701


<210> 140
<211> 306
<212> PRT
<213> Mus musculus

<400> 140
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     


Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         


Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             


Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 


Phe Leu 
305     


<210> 141
<211> 2720
<212> DNA
<213> Homo sapiens

<400> 141
agtcattgcc gaggaaggct tgcacagggt gaaagctttg cttctctgct gctgtaacag       60

ggactagcac agacacacgg atgagtgggg tcatttccag atattaggtc acagcagaag      120

cagccaaaat ggatccccag tgcactatgg gactgagtaa cattctcttt gtgatggcct      180

tcctgctctc tggtgctgct cctctgaaga ttcaagctta tttcaatgag actgcagacc      240

tgccatgcca atttgcaaac tctcaaaacc aaagcctgag tgagctagta gtattttggc      300

aggaccagga aaacttggtt ctgaatgagg tatacttagg caaagagaaa tttgacagtg      360

ttcattccaa gtatatgggc cgcacaagtt ttgattcgga cagttggacc ctgagacttc      420

acaatcttca gatcaaggac aagggcttgt atcaatgtat catccatcac aaaaagccca      480

caggaatgat tcgcatccac cagatgaatt ctgaactgtc agtgcttgct aacttcagtc      540

aacctgaaat agtaccaatt tctaatataa cagaaaatgt gtacataaat ttgacctgct      600

catctataca cggttaccca gaacctaaga agatgagtgt tttgctaaga accaagaatt      660

caactatcga gtatgatggt gttatgcaga aatctcaaga taatgtcaca gaactgtacg      720

acgtttccat cagcttgtct gtttcattcc ctgatgttac gagcaatatg accatcttct      780

gtattctgga aactgacaag acgcggcttt tatcttcacc tttctctata gagcttgagg      840

accctcagcc tcccccagac cacattcctt ggattacagc tgtacttcca acagttatta      900

tatgtgtgat ggttttctgt ctaattctat ggaaatggaa gaagaagaag cggcctcgca      960

actcttataa atgtggaacc aacacaatgg agagggaaga gagtgaacag accaagaaaa     1020

gagaaaaaat ccatatacct gaaagatctg atgaagccca gcgtgttttt aaaagttcga     1080

agacatcttc atgcgacaaa agtgatacat gtttttaatt aaagagtaaa gcccatacaa     1140

gtattcattt tttctaccct ttcctttgta agttcctggg caaccttttt gatttcttcc     1200

agaaggcaaa aagacattac catgagtaat aagggggctc caggactccc tctaagtgga     1260

atagcctccc tgtaactcca gctctgctcc gtatgccaag aggagacttt aattctctta     1320

ctgcttcttt tcacttcaga gcacacttat gggccaagcc cagcttaatg gctcatgacc     1380

tggaaataaa atttaggacc aatacctcct ccagatcaga ttcttctctt aatttcatag     1440

attgtgtttt ttttttaaat agacctctca atttctggaa aactgccttt tatctgccca     1500

gaattctaag ctggtgcccc actgaatttt gtgtgtacct gtgactaaac aactacctcc     1560

tcagtctggg tgggacttat gtatttatga ccttatagtg ttaatatctt gaaacataga     1620

gatctatgta ctgtaatagt gtgattacta tgctctagag aaaagtctac ccctgctaag     1680

gagttctcat ccctctgtca gggtcagtaa ggaaaacggt ggcctagggt acaggcaaca     1740

atgagcagac caacctaaat ttggggaaat taggagaggc agagatagaa cctggagcca     1800

cttctatctg ggctgttgct aatattgagg aggcttgccc cacccaacaa gccatagtgg     1860

agagaactga ataaacagga aaatgccaga gcttgtgaac cctgtttctc ttgaagaact     1920

gactagtgag atggcctggg gaagctgtga aagaaccaaa agagatcaca atactcaaaa     1980

gagagagaga gagaaaaaag agagatcttg atccacagaa atacatgaaa tgtctggtct     2040

gtccacccca tcaacaagtc ttgaaacaag caacagatgg atagtctgtc caaatggaca     2100

taagacagac agcagtttcc ctggtggtca gggaggggtt ttggtgatac ccaagttatt     2160

gggatgtcat cttcctggaa gcagagctgg ggagggagag ccatcacctt gataatggga     2220

tgaatggaag gaggcttagg actttccact cctggctgag agaggaagag ctgcaacgga     2280

attaggaaga ccaagacaca gatcacccgg ggcttactta gcctacagat gtcctacggg     2340

aacgtgggct ggcccagcat agggctagca aatttgagtt ggatgattgt ttttgctcaa     2400

ggcaaccaga ggaaacttgc atacagagac agatatactg ggagaaatga ctttgaaaac     2460

ctggctctaa ggtgggatca ctaagggatg gggcagtctc tgcccaaaca taaagagaac     2520

tctggggagc ctgagccaca aaaatgttcc tttattttat gtaaaccctc aagggttata     2580

gactgccatg ctagacaagc ttgtccatgt aatattccca tgtttttacc ctgcccctgc     2640

cttgattaga ctcctagcac ctggctagtt tctaacatgt tttgtgcagc acagttttta     2700

ataaatgctt gttacattca                                                 2720


<210> 142
<211> 329
<212> PRT
<213> Homo sapiens

<400> 142
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210> 143
<211> 2539
<212> DNA
<213> Mus musculus

<400> 143
attgctgagg aagaaagagg agcaagcaga cgcgtaagag tggctcctgt aggcagcacg       60

gacttgaaca accagactcc tgtagacgtg ttccagaact tacggaagca cccacgatgg      120

accccagatg caccatgggc ttggcaatcc ttatctttgt gacagtcttg ctgatctcag      180

atgctgtttc cgtggagacg caagcttatt tcaatgggac tgcatatctg ccgtgcccat      240

ttacaaaggc tcaaaacata agcctgagtg agctggtagt attttggcag gaccagcaaa      300

agttggttct gtacgagcac tatttgggca cagagaaact tgatagtgtg aatgccaagt      360

acctgggccg cacgagcttt gacaggaaca actggactct acgacttcac aatgttcaga      420

tcaaggacat gggctcgtat gattgtttta tacaaaaaaa gccacccaca ggatcaatta      480

tcctccaaca gacattaaca gaactgtcag tgatcgccaa cttcagtgaa cctgaaataa      540

aactggctca gaatgtaaca ggaaattctg gcataaattt gacctgcacg tctaagcaag      600

gtcacccgaa acctaagaag atgtattttc tgataactaa ttcaactaat gagtatggtg      660

ataacatgca gatatcacaa gataatgtca cagaactgtt cagtatctcc aacagcctct      720

ctctttcatt cccggatggt gtgtggcata tgaccgttgt gtgtgttctg gaaacggagt      780

caatgaagat ttcctccaaa cctctcaatt tcactcaaga gtttccatct cctcaaacgt      840

attggaagga gattacagct tcagttactg tggccctcct ccttgtgatg ctgctcatca      900

ttgtatgtca caagaagccg aatcagccta gcaggcccag caacacagcc tctaagttag      960

agcgggatag taacgctgac agagagacta tcaacctgaa ggaacttgaa ccccaaattg     1020

cttcagcaaa accaaatgca gagtgaaggc agtgagagcc tgaggaaaga gttaaaaatt     1080

gctttgcctg aaataagaag tgcagagttt ctcagaattc aaaaatgttc tcagctgatt     1140

ggaattctac agttgaataa ttaaagaaca aaatacacaa cagtgtccat attttatcct     1200

gtttcctttc caagtttttg ggcaatgtca attgtgtccc ctatgccagg agcagacatc     1260

tattttgtct tgctttgttt aactcagtgc acactcatag gccaagagca ctgaaatggc     1320

ttctttccca ggaataacat tttggatcaa tctctcctac ttgagatcag attcttcttc     1380

taattttgca tagtgtgttt ttatatggaa ctccttgttg taggaatact ggcttttatc     1440

tgtcttgcac acttgcatac ttatatactt atacctggac agctacctct tcagtcagga     1500

tgggagtggt atatttggtg atgttatttg atgtgttcgt gttgctatct taaaacagca     1560

aagagcatat actatagtag ctcaactaca atgatctaga gaaagaccca gcacttataa     1620

gaaacactgt ccctccatca gggtcaataa tgaatacaat gacctaagta atatacaggt     1680

gacagcaaca gcacagagtt ctcagtgctg gcaaatcaag aaacacaaat atggaaccat     1740

ctctagatcc aagagccact cctacctggg ctgccacaga tactggaaga atccacctgc     1800

ctggccagca agtcacaact tagcaggcag cactgaagaa agcaagatgt actgtatgcc     1860

cttttaagaa aatgcctgga aaggtctgga gaatgctgtg caaggataag acagccaagc     1920

actcaaaacc aggagacatc actagaatcc aaccaacaaa tgtttatgga aggactgatc     1980

tgcccagtcc attgaaaagt caagaggtca gagatagacc agtgtgtgtc tcaatggatg     2040

tagatatcag ccacctcggt gctcaacagg tattttatga tctccttgtt tcaaattcat     2100

ctagatgtag aactagggag agagcagtca cattgatgaa aggctaggac tctttcagct     2160

catggcttgt gtggaaggag ggaaagcaga aatcacaaca ctctgagact actgtagtct     2220

gcagatacct gagtgggtgt ggcttggcct ttcaaaggac aaagagcaac taatgctgaa     2280

agcacatagt gtatctatac ggcatggaat agtcatcacc cagacttaaa gagaactttg     2340

gcaggtctga gcagcaaaat attgttgttt ccattttaca taaagggccc tggagggcta     2400

tagactattc cgctggcagg gctcatgctt gtaatgtgtc catcttgatt caccctgtgc     2460

agactcttaa gatctggcca gttaccaaca tgttctgtac agagtggatt tcaataaagt     2520

tttcttgaat tttttcaag                                                  2539


<210> 144
<211> 309
<212> PRT
<213> Mus musculus

<400> 144
Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      


Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          


Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             


Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 


Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 


Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     


Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         


Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             


Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 


Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 


Thr Tyr Trp Lys Glu Ile Thr Ala Ser Val Thr Val Ala Leu Leu Leu 
                245                 250                 255     


Val Met Leu Leu Ile Ile Val Cys His Lys Lys Pro Asn Gln Pro Ser 
            260                 265                 270         


Arg Pro Ser Asn Thr Ala Ser Lys Leu Glu Arg Asp Ser Asn Ala Asp 
        275                 280                 285             


Arg Glu Thr Ile Asn Leu Lys Glu Leu Glu Pro Gln Ile Ala Ser Ala 
    290                 295                 300                 


Lys Pro Asn Ala Glu 
305                 


<210> 145
<211> 1086
<212> DNA
<213> Homo sapiens

<400> 145
gaacttaggg ctgcttgtgg ctgggcactc gcgcagaggc cggcccgacg agccatggtt       60

gctgggagcg acgcggggcg ggccctgggg gtcctcagcg tggtctgcct gctgcactgc      120

tttggtttca tcagctgttt ttcccaacaa atatatggtg ttgtgtatgg gaatgtaact      180

ttccatgtac caagcaatgt gcctttaaaa gaggtcctat ggaaaaaaca aaaggataaa      240

gttgcagaac tggaaaattc tgaattcaga gctttctcat cttttaaaaa tagggtttat      300

ttagacactg tgtcaggtag cctcactatc tacaacttaa catcatcaga tgaagatgag      360

tatgaaatgg aatcgccaaa tattactgat accatgaagt tctttcttta tgtgcttgag      420

tctcttccat ctcccacact aacttgtgca ttgactaatg gaagcattga agtccaatgc      480

atgataccag agcattacaa cagccatcga ggacttataa tgtactcatg ggattgtcct      540

atggagcaat gtaaacgtaa ctcaaccagt atatatttta agatggaaaa tgatcttcca      600

caaaaaatac agtgtactct tagcaatcca ttatttaata caacatcatc aatcattttg      660

acaacctgta tcccaagcag cggtcattca agacacagat atgcacttat acccatacca      720

ttagcagtaa ttacaacatg tattgtgctg tatatgaatg gtattctgaa atgtgacaga      780

aaaccagaca gaaccaactc caattgattg gtaacagaag atgaagacaa cagcataact      840

aaattatttt aaaaactaaa aagccatctg atttctcatt tgagtattac aatttttgaa      900

caactgttgg aaatgtaact tgaagcagct gctttaagaa gaaataccca ctaacaaaga      960

acaagcatta gttttggctg tcatcaactt attatatgac taggtgcttg ctttttttgt     1020

cagtaaattg tttttactga tgatgtagat acttttgtaa ataaatgtaa atatgtacac     1080

aagtga                                                                1086


<210> 146
<211> 250
<212> PRT
<213> Homo sapiens

<400> 146
Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210> 147
<211> 3749
<212> DNA
<213> Homo sapiens

<400> 147
agacagcctc tgctgcatga cacgaagctt gcttctgcct ggcatctgtg agcagctgcc       60

aggctccggc caggatccct tccttctcct cattggctga tggatcccaa ggggctcctc      120

tccttgacct tcgtgctgtt tctctccctg gcttttgggg caagctacgg aacaggtggg      180

cgcatgatga actgcccaaa gattctccgg cagttgggaa gcaaagtgct gctgcccctg      240

acatatgaaa ggataaataa gagcatgaac aaaagcatcc acattgtcgt cacaatggca      300

aaatcactgg agaacagtgt cgagaacaaa atagtgtctc ttgatccatc cgaagcaggc      360

cctccacgtt atctaggaga tcgctacaag ttttatctgg agaatctcac cctggggata      420

cgggaaagca ggaaggagga tgagggatgg taccttatga ccctggagaa aaatgtttca      480

gttcagcgct tttgcctgca gttgaggctt tatgagcagg tctccactcc agaaattaaa      540

gttttaaaca agacccagga gaacgggacc tgcaccttga tactgggctg cacagtggag      600

aagggggacc atgtggctta cagctggagt gaaaaggcgg gcacccaccc actgaaccca      660

gccaacagct cccacctcct gtccctcacc ctcggccccc agcatgctga caatatctac      720

atctgcaccg tgagcaaccc tatcagcaac aattcccaga ccttcagccc gtggcccgga      780

tgcaggacag acccctcaga aacaaaacca tgggcagtgt atgctgggct gttagggggt      840

gtcatcatga ttctcatcat ggtggtaata ctacagttga gaagaagagg taaaacgaac      900

cattaccaga caacagtgga aaaaaaaagc cttacgatct atgcccaagt ccagaaacca      960

ggtcctcttc agaagaaact tgactccttc ccagctcagg acccttgcac caccatatat     1020

gttgctgcca cagagcctgt cccagagtct gtccaggaaa caaattccat cacagtctat     1080

gctagtgtga cacttccaga gagctgacac cagagaccaa caaagggact ttctgaagga     1140

aaatggaaaa accaaaatga acactgaact tggccacagg ccccaagttt cctctggcag     1200

acatgctgca cgtctgtacc cttctcagat caactccctg gtgatgtttc ttccacatac     1260

atctgtgaaa tgaacaagga agtgaggctt cccaagaatt tagcttgctg tgcagtggct     1320

gcaggcgcag aacagagcgt tacttgataa cagcgttcca tctttgtgtt gtagcagatg     1380

aaatggacag taatgtgagt tcagactttg ggcatcttgc tcttggctgg aactggataa     1440

taaaaatcag actgaaagcc aggacatctg agtacctatc tcacacactg gaccaccagt     1500

cacaaagtct ggaaaagttt acattttggc tatctttact ttgttctggg agctgatcat     1560

gataacctgc agacctgatc aagcctctgt gcctcagttt ctctctcagg ataaagagtg     1620

aatagaggct gaagggtgaa tttcttatta tacataaaac actctgatat tattgtataa     1680

aggaagctaa gaatattatt ttatttgcaa aacccagaag ctaaaaagtc aataaacaga     1740

aagaatgatt ttgagatctc tgagttttga acagtggact ggaaaccatg taagagcctt     1800

aaaagtacag ttctgtgcaa atggcattca gttttaaaga aaaacgtagc aaatgtttga     1860

tggtgctgtt acaaaggagc ttggaatact cagaggaact tgtcccatgg tgatttttca     1920

cttctcaaaa tgatgtttaa atcccagttc tctgttgatt cccttgaaca acaaacctgg     1980

aacctcagct aagactctct gtgaccagat tctgaacctc ttatatccag ggcttcaagg     2040

ggtattgcag gtcaaggtct ttcctaggca ctttctactc cctgcatacc tctcctcaca     2100

ctaaatttat cctctagtag aaaattaagt tattttggtc taacagcttc aaatctttga     2160

atgctcaata acttattttg caagctgcag gcagaaagag actttttaag taaagtcctt     2220

tgttttttcc tattctctgc ttttagacag gctgtcctca atttaagccc tgctttttct     2280

tattgtttct tatataaact tggtaagtac tgtaagaaac agccactatc ataccattgc     2340

ataataagga gcaccaactt cccagctcaa aactcaggtc cttattgcct tgtatcttac     2400

ctcctctatg aggtcaattc acattgtaag cctgttgctt agtgcatctc gtttcctggt     2460

accagcttct ttaatagagt tcttagttgc aatcaacaga agctggcttt ggctttttta     2520

tgtagaaaag gaacctattg aaaagatact gattggttcc aataactgct agaagtttct     2580

gcaaaaccat gctttgaaag tgagcaggaa aagaagagac taggctgtgg ctgggagcac     2640

agccaaaatt acaaaaccag cccagggatg atgatcctgt tcatgcacag ccactgtccc     2700

cagcactagg cacagactct accactgcct cactgtctct gctggacttg gaaacttgat     2760

attactgtta ctgctgcact gtctgccatg aaaatgaatt ctccagggtc ccttcttcat     2820

cctttcatct ctagcttata attcaaagtc tgggattgag tggccaatcc taggtcacat     2880

gtccatgtcc tatctccaag gggggctggg aattgaatat ctggcatttt ccactttcac     2940

ttcttatgaa ttaaggaatt ctacaaataa tagaagtggg attcaggtgg taggcagaca     3000

aaaaagcctc acaattatcc actacgccac ccttgtataa ccttaccctc attcactgtc     3060

tactctcaaa actgtggagc tactaatgaa gatttgtaaa cccgggctta tgagcaccca     3120

ttcctttact acaactcaga ttgctctaga agctcagttc ccagcacttg gatttttcca     3180

gtagctgaat tctacctgaa ggaagggcag aaacaaaggg tgaagaagag gctatcactt     3240

ccaagtatcc tgcacccctg ggctcaagac ctcactgggg agggagtctt ttgggccacc     3300

caccaaacag cactggcatt atgcctctca ccctagacca tggttacacg tggtaaaaca     3360

accccttctg gtgatacatt cacaactctc tagtttcccc caaatggcac tatggggagc     3420

gggagcttgc cttttcctca gacttaaaac aataagtttt ccccgtgttt cccctctaat     3480

gctgttttct tttgaccaag catgtctgaa ttctagagaa gtcaggagga acacacccat     3540

tctcggtttg aagggactga tgttctgaag tacaactggg cacagtccca ggctcttcag     3600

gacgcttcct ccattcacac agcggggatg tgattgttac agcgggtggt gtgtgctggc     3660

tgagaagcca ctgtgaattg attcttcttc tgaagtttat gtttctactt tttggaaatg     3720

aataaattac agccagtcca tcaaggaaa                                       3749


<210> 148
<211> 335
<212> PRT
<213> Homo sapiens

<400> 148
Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          


Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              


Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  


Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  


Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      


Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         


Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             


Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 


Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 


Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     


Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         


Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             


Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 


Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 


Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     


Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         


Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             


Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 


Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 


Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 


<210> 149
<211> 2688
<212> DNA
<213> Mus musculus

<400> 149
gagcttcttc cttgggggta acagtaagca gctgtcctgc cgagctgagc tgagctgagc       60

tcacagctgg ggaccctgtc tgcgattgct ggctaatgga tcccaaagga tccctttcct      120

ggagaatact tctgtttctc tccctggctt ttgagttgag ctacggaaca ggtggaggtg      180

tgatggattg cccagtgatt ctccagaagc tgggacagga cacgtggctg cccctgacga      240

atgaacatca gataaataag agcgtgaaca aaagtgtccg catcctcgtc accatggcga      300

cgtccccagg aagcaaatcc aacaagaaaa ttgtgtcttt tgatctctct aaagggagct      360

atccagatca cctggaggat ggctaccact ttcaatcaaa aaacctgagc ctgaagatcc      420

tcgggaacag gcgggagagt gaaggatggt acttggtgag cgtggaggag aacgtttctg      480

ttcagcaatt ctgcaagcag ctgaagcttt atgaacaggt ctcccctcca gagattaaag      540

tgctaaacaa aacccaggag aacgagaatg ggacctgcag cttgctgttg gcctgcacag      600

tgaagaaagg ggaccatgtg acttacagct ggagtgatga ggcaggcacc cacctgctga      660

gccgagccaa ccgctcccac ctcctgcaca tcactcttag caaccagcat caagacagca      720

tctacaactg caccgcaagc aaccctgtca gcagtatctc taggaccttc aacctatcat      780

cgcaagcatg caagcaggaa tcctcctcag aatcgagtcc atggatgcaa tatactcttg      840

taccactggg ggtcgttata atcttcatcc tggttttcac ggcaataata atgatgaaaa      900

gacaaggtaa atcaaatcac tgccagccac cagtggaaga aaaaagcctt actatttatg      960

cccaagtaca gaaatcaggg cctcaagaga agaaacttca tgatgcccta acagatcagg     1020

acccctgcac aaccatttat gtggctgcca cagagcctgc cccagagtct gtccaggaac     1080

caaaccccac cacagtttat gccagtgtga cactgccaga gagctgaccc atatacccag     1140

tgaaaggact ttttgaagga ggatagaaga accaaaatcc acactgaact ggaccccggg     1200

tcccaagttc tctgtgacag aaactgcaca tctgtaacct tctccaatca gttccctggt     1260

gacggatctg cacaggcgtg cttatgaagt agatgagaag tgaggcttcc tgggcatgca     1320

acctgctctg ctgctgacac agatatgaag cagagatccc gtggtacagt gtaccatctt     1380

tgctgtagca gataatgtgg gtttaggcat ctcactcttt gctggactgg ataacagaac     1440

tcaaaaaaaa accaacaagc caaagacata gactccatct cagatggctg agcacaaagt     1500

ataaaagcca ttttggctct ctggacttta ttctggaagc tgatcctgat cacctcaagg     1560

ccaagggctc catgcctcag tttctctctc accctctaga tgaagaggga acaaagcata     1620

aagagtgaaa tccttgttgt ctgagatcat tctataaacg aactgacatt ttatttgcaa     1680

aactcaagct agtaattcag tagacttgaa gatgatttta gagcctctta tgcttcaaac     1740

aacagaatga aatccatcca atgttcttca aagtgtggtt ctctgattaa gtcaaagcaa     1800

cactgtttgg caatgctgct gtaaagttgc ctggaatact cagaggaact tgtcccaggg     1860

aggttttttt cacttcttca aagaactttt gaatttaagt tctctgttta ttcccttgag     1920

caaaactctg gaacctcaag agtctctctc cgttggttct gaggccattt tatagcctag     1980

gcctcctgtg gatctacatg tgtatcaccc acttcctatc tcactgcata cctctgtgta     2040

gtagtaaatt taacctcaag tagaaaatta aattattttg gatgatcagt tccaaatgat     2100

tagatgttta gtctcttata ataggatgta ggtagagtct atataaagtc ctatattctt     2160

cacgttgtct gtcctcagag agaccatctt tcaacctatc ttccttcttg cacaactttg     2220

gcaaatactt taaaaataac cattgtggag atggggagag gtctaaatgg ataatagtac     2280

ttgctttgca aacatgaaga tctgggttca aactcccagt gtccatgtaa aaagataagt     2340

gtggttgagt gtgccagtaa catagacaca gataggtcct gagactttgc tccctagcct     2400

tcccagccag gcataaatgt caagtcccct gagagtgaca gaggaagata ctccccccac     2460

acacacacac atacacgcac agtgatacac atatacatgc atacaaaaaa aaaacttatt     2520

gtaacaaaga acaccaactg cctggctcaa aactctcatg tcccattact ctgtaccttt     2580

ctgtatttag ataatttaca gtgtgagttc tgctgttcca tgtatcctat ttgtgttact     2640

aacttatgtc aaagtatttc taattataat caacaaaagc taactttg                  2688


<210> 150
<211> 343
<212> PRT
<213> Mus musculus

<400> 150
Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Thr Gly Gly Gly Val Met Asp Cys 
            20                  25                  30          


Pro Val Ile Leu Gln Lys Leu Gly Gln Asp Thr Trp Leu Pro Leu Thr 
        35                  40                  45              


Asn Glu His Gln Ile Asn Lys Ser Val Asn Lys Ser Val Arg Ile Leu 
    50                  55                  60                  


Val Thr Met Ala Thr Ser Pro Gly Ser Lys Ser Asn Lys Lys Ile Val 
65                  70                  75                  80  


Ser Phe Asp Leu Ser Lys Gly Ser Tyr Pro Asp His Leu Glu Asp Gly 
                85                  90                  95      


Tyr His Phe Gln Ser Lys Asn Leu Ser Leu Lys Ile Leu Gly Asn Arg 
            100                 105                 110         


Arg Glu Ser Glu Gly Trp Tyr Leu Val Ser Val Glu Glu Asn Val Ser 
        115                 120                 125             


Val Gln Gln Phe Cys Lys Gln Leu Lys Leu Tyr Glu Gln Val Ser Pro 
    130                 135                 140                 


Pro Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Glu Asn Gly Thr 
145                 150                 155                 160 


Cys Ser Leu Leu Leu Ala Cys Thr Val Lys Lys Gly Asp His Val Thr 
                165                 170                 175     


Tyr Ser Trp Ser Asp Glu Ala Gly Thr His Leu Leu Ser Arg Ala Asn 
            180                 185                 190         


Arg Ser His Leu Leu His Ile Thr Leu Ser Asn Gln His Gln Asp Ser 
        195                 200                 205             


Ile Tyr Asn Cys Thr Ala Ser Asn Pro Val Ser Ser Ile Ser Arg Thr 
    210                 215                 220                 


Phe Asn Leu Ser Ser Gln Ala Cys Lys Gln Glu Ser Ser Ser Glu Ser 
225                 230                 235                 240 


Ser Pro Trp Met Gln Tyr Thr Leu Val Pro Leu Gly Val Val Ile Ile 
                245                 250                 255     


Phe Ile Leu Val Phe Thr Ala Ile Ile Met Met Lys Arg Gln Gly Lys 
            260                 265                 270         


Ser Asn His Cys Gln Pro Pro Val Glu Glu Lys Ser Leu Thr Ile Tyr 
        275                 280                 285             


Ala Gln Val Gln Lys Ser Gly Pro Gln Glu Lys Lys Leu His Asp Ala 
    290                 295                 300                 


Leu Thr Asp Gln Asp Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu 
305                 310                 315                 320 


Pro Ala Pro Glu Ser Val Gln Glu Pro Asn Pro Thr Thr Val Tyr Ala 
                325                 330                 335     


Ser Val Thr Leu Pro Glu Ser 
            340             


<210> 151
<211> 1682
<212> DNA
<213> Homo sapiens

<400> 151
agtggtcctg ccgcctggtc tcacctcgct atggttcgtc tgcctctgca gtgcgtcctc       60

tggggctgct tgctgaccgc tgtccatcca gaaccaccca ctgcatgcag agaaaaacag      120

tacctaataa acagtcagtg ctgttctttg tgccagccag gacagaaact ggtgagtgac      180

tgcacagagt tcactgaaac ggaatgcctt ccttgcggtg aaagcgaatt cctagacacc      240

tggaacagag agacacactg ccaccagcac aaatactgcg accccaacct agggcttcgg      300

gtccagcaga agggcacctc agaaacagac accatctgca cctgtgaaga aggctggcac      360

tgtacgagtg aggcctgtga gagctgtgtc ctgcaccgct catgctcgcc cggctttggg      420

gtcaagcaga ttgctacagg ggtttctgat accatctgcg agccctgccc agtcggcttc      480

ttctccaatg tgtcatctgc tttcgaaaaa tgtcaccctt ggacaagctg tgagaccaaa      540

gacctggttg tgcaacaggc aggcacaaac aagactgatg ttgtctgtgg tccccaggat      600

cggctgagag ccctggtggt gatccccatc atcttcggga tcctgtttgc catcctcttg      660

gtgctggtct ttatcaaaaa ggtggccaag aagccaacca ataaggcccc ccaccccaag      720

caggaacccc aggagatcaa ttttcccgac gatcttcctg gctccaacac tgctgctcca      780

gtgcaggaga ctttacatgg atgccaaccg gtcacccagg aggatggcaa agagagtcgc      840

atctcagtgc aggagagaca gtgaggctgc acccacccag gagtgtggcc acgtgggcaa      900

acaggcagtt ggccagagag cctggtgctg ctgctgctgt ggcgtgaggg tgaggggctg      960

gcactgactg ggcatagctc cccgcttctg cctgcacccc tgcagtttga gacaggagac     1020

ctggcactgg atgcagaaac agttcacctt gaagaacctc tcacttcacc ctggagccca     1080

tccagtctcc caacttgtat taaagacaga ggcagaagtt tggtggtggt ggtgttgggg     1140

tatggtttag taatatccac cagaccttcc gatccagcag tttggtgccc agagaggcat     1200

catggtggct tccctgcgcc caggaagcca tatacacaga tgcccattgc agcattgttt     1260

gtgatagtga acaactggaa gctgcttaac tgtccatcag caggagactg gctaaataaa     1320

attagaatat atttatacaa cagaatctca aaaacactgt tgagtaagga aaaaaaggca     1380

tgctgctgaa tgatgggtat ggaacttttt aaaaaagtac atgcttttat gtatgtatat     1440

tgcctatgga tatatgtata aatacaatat gcatcatata ttgatataac aagggttctg     1500

gaagggtaca cagaaaaccc acagctcgaa gagtggtgac gtctggggtg gggaagaagg     1560

gtctggggga gggttggtta aagggagatt tggctttccc ataatgcttc atcatttttc     1620

ccaaaaggag agtgaattca cataatgctt atgtaattaa aaaatcatca aacatgtaaa     1680

aa                                                                    1682


<210> 152
<211> 277
<212> PRT
<213> Homo sapiens

<400> 152
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210> 153
<211> 1621
<212> DNA
<213> Mus musculus

<400> 153
agcagggact ttggagtgac ttgtggcttc agcaggagcc ctgtgatttg gctcttctga       60

tctcgccctg cgatggtgtc tttgcctcgg ctgtgcgcgc tatggggctg cttgttgaca      120

gcggtccatc tagggcagtg tgttacgtgc agtgacaaac agtacctcca cgatggccag      180

tgctgtgatt tgtgccagcc aggaagccga ctgacaagcc actgcacagc tcttgagaag      240

acccaatgcc acccatgtga ctcaggcgaa ttctcagccc agtggaacag ggagattcgc      300

tgtcaccagc acagacactg tgaacccaat caagggcttc gggttaagaa ggagggcacc      360

gcagaatcag acactgtctg tacctgtaag gaaggacaac actgcaccag caaggattgc      420

gaggcatgtg ctcagcacac gccctgtatc cctggctttg gagttatgga gatggccact      480

gagaccactg ataccgtctg tcatccctgc ccagtcggct tcttctccaa tcagtcatca      540

cttttcgaaa agtgttatcc ctggacaagg tttaaagtcc cggatgcgag ccctgctggt      600

cattcctgtc gtgatgggca tcctcatcac cattttcggg gtgtttctct atatcaaaaa      660

ggtggtcaag aaaccaaagg ataatgagat cttaccccct gcggctcgac ggcaagatcc      720

ccaggagatg gaagattatc ccggtcataa caccgctgct ccagtgcagg agacgctgca      780

cgggtgtcag cctgtcacac aggaggatgg taaagagagt cgcatctcag tgcaggagcg      840

gcaggtgaca gacagcatag ccttgaggcc cctggtctga accctggaac tgctttggag      900

gcgatggctc ggctcgggag caggggcctg gctctgagga ctgcttgctg acctttgaag      960

tttgagatga gccaagacag agcccagtgc agctaactct catgcctgcc ccctatcatt     1020

tctcaacttg ctttttaagg atggagggag agctcgggca tcgggggtcc acagtgatac     1080

ctaccaagtg cagcagtgca ggacccagag tcgtcttgct gcggcgttca ctgtaaggag     1140

tcatggacac aggagtccgt ggcccacagc ttgtgctgct agagggcacc tggttgccca     1200

tcagcagggt actggctaaa taaatctgta attatttata caatgacatc tcagaaactc     1260

tagcaggtgg ggcagaaaac aggtagtaga atgatgggta gagaaatagc ttttaaaaca     1320

cattccaagg caggtaagat ggcttttgtg agtaaaggag cttgctgccc aaacccggtt     1380

acctgatttt gatccctggg acttcatggt aaaagggaga gaaccaaatc cagagggttg     1440

tcatttgacc tccatgtgtg ctctgtggta atgtaccccg tgtgtgcaca tgtgcacata     1500

tcctaaaatg gatgtggtgg tgtattgtag aaattattta atcccgccct ggggtttcta     1560

cctgtgtgtt accatttagt tcttgaataa aagacacact caacctttat atttacaata     1620

a                                                                     1621


<210> 154
<211> 203
<212> PRT
<213> Mus musculus

<400> 154
Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu Gly Gln Cys Val Thr Cys Ser Asp Lys Gln Tyr Leu 
            20                  25                  30          


His Asp Gly Gln Cys Cys Asp Leu Cys Gln Pro Gly Ser Arg Leu Thr 
        35                  40                  45              


Ser His Cys Thr Ala Leu Glu Lys Thr Gln Cys His Pro Cys Asp Ser 
    50                  55                  60                  


Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu Ile Arg Cys His Gln His 
65                  70                  75                  80  


Arg His Cys Glu Pro Asn Gln Gly Leu Arg Val Lys Lys Glu Gly Thr 
                85                  90                  95      


Ala Glu Ser Asp Thr Val Cys Thr Cys Lys Glu Gly Gln His Cys Thr 
            100                 105                 110         


Ser Lys Asp Cys Glu Ala Cys Ala Gln His Thr Pro Cys Ile Pro Gly 
        115                 120                 125             


Phe Gly Val Met Glu Met Ala Thr Glu Thr Thr Asp Thr Val Cys His 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Gln Ser Ser Leu Phe Glu Lys 
145                 150                 155                 160 


Cys Tyr Pro Trp Thr Arg Phe Lys Val Pro Asp Ala Ser Pro Ala Gly 
                165                 170                 175     


His Ser Cys Arg Asp Gly His Pro His His His Phe Arg Gly Val Ser 
            180                 185                 190         


Leu Tyr Gln Lys Gly Gly Gln Glu Thr Lys Gly 
        195                 200             


<210> 155
<211> 4721
<212> DNA
<213> Homo sapiens

<400> 155
acacttcggg ttcctcgggg aggaggggct ggaaccctag cccatcgtca ggacaaagat       60

gctcaggctg ctcttggctc tcaacttatt cccttcaatt caagtaacag gaaacaagat      120

tttggtgaag cagtcgccca tgcttgtagc gtacgacaat gcggtcaacc ttagctgcaa      180

gtattcctac aatctcttct caagggagtt ccgggcatcc cttcacaaag gactggatag      240

tgctgtggaa gtctgtgttg tatatgggaa ttactcccag cagcttcagg tttactcaaa      300

aacggggttc aactgtgatg ggaaattggg caatgaatca gtgacattct acctccagaa      360

tttgtatgtt aaccaaacag atatttactt ctgcaaaatt gaagttatgt atcctcctcc      420

ttacctagac aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg      480

tccaagtccc ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg      540

agtcctggct tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag      600

taagaggagc aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc      660

cacccgcaag cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctcctg      720

acacggacgc ctatccagaa gccagccggc tggcagcccc catctgctca atatcactgc      780

tctggatagg aaatgaccgc catctccagc cggccacctc aggcccctgt tgggccacca      840

atgccaattt ttctcgagtg actagaccaa atatcaagat cattttgaga ctctgaaatg      900

aagtaaaaga gatttcctgt gacaggccaa gtcttacagt gccatggccc acattccaac      960

ttaccatgta cttagtgact tgactgagaa gttagggtag aaaacaaaaa gggagtggat     1020

tctgggagcc tcttcccttt ctcactcacc tgcacatctc agtcaagcaa agtgtggtat     1080

ccacagacat tttagttgca gaagaaaggc taggaaatca ttccttttgg ttaaatgggt     1140

gtttaatctt ttggttagtg ggttaaacgg ggtaagttag agtaggggga gggataggaa     1200

gacatattta aaaaccatta aaacactgtc tcccactcat gaaatgagcc acgtagttcc     1260

tatttaatgc tgttttcctt tagtttagaa atacatagac attgtctttt atgaattctg     1320

atcatattta gtcattttga ccaaatgagg gatttggtca aatgagggat tccctcaaag     1380

caatatcagg taaaccaagt tgctttcctc actccctgtc atgagacttc agtgttaatg     1440

ttcacaatat actttcgaaa gaataaaata gttctcctac atgaagaaag aatatgtcag     1500

gaaataaggt cactttatgt caaaattatt tgagtactat gggacctggc gcagtggctc     1560

atgcttgtaa tcccagcact ttgggaggcc gaggtgggca gatcacttga gatcaggacc     1620

agcctggtca agatggtgaa actccgtctg tactaaaaat acaaaattta gcttggcctg     1680

gtggcaggca cctgtaatcc cagctgccca agaggctgag gcatgagaat cgcttgaacc     1740

tggcaggcgg aggttgcagt gagccgagat agtgccacag ctctccagcc tgggcgacag     1800

agtgagactc catctcaaac aacaacaaca acaacaacaa caacaacaaa ccacaaaatt     1860

atttgagtac tgtgaaggat tatttgtcta acagttcatt ccaatcagac caggtaggag     1920

ctttcctgtt tcatatgttt cagggttgca cagttggtct ctttaatgtc ggtgtggaga     1980

tccaaagtgg gttgtggaaa gagcgtccat aggagaagtg agaatactgt gaaaaaggga     2040

tgttagcatt cattagagta tgaggatgag tcccaagaag gttctttgga aggaggacga     2100

atagaatgga gtaatgaaat tcttgccatg tgctgaggag atagccagca ttaggtgaca     2160

atcttccaga agtggtcagg cagaaggtgc cctggtgaga gctcctttac agggacttta     2220

tgtggtttag ggctcagagc tccaaaactc tgggctcagc tgctcctgta ccttggaggt     2280

ccattcacat gggaaagtat tttggaatgt gtcttttgaa gagagcatca gagttcttaa     2340

gggactgggt aaggcctgac cctgaaatga ccatggatat ttttctacct acagtttgag     2400

tcaactagaa tatgcctggg gaccttgaag aatggccctt cagtggccct caccatttgt     2460

tcatgcttca gttaattcag gtgttgaagg agcttaggtt ttagaggcac gtagacttgg     2520

ttcaagtctc gttagtagtt gaatagcctc aggcaagtca ctgcccacct aagatgatgg     2580

ttcttcaact ataaaatgga gataatggtt acaaatgtct cttcctatag tataatctcc     2640

ataagggcat ggcccaagtc tgtctttgac tctgcctatc cctgacattt agtagcatgc     2700

ccgacataca atgttagcta ttggtattat tgccatatag ataaattatg tataaaaatt     2760

aaactgggca atagcctaag aaggggggaa tattgtaaca caaatttaaa cccactacgc     2820

agggatgagg tgctataata tgaggacctt ttaacttcca tcattttcct gtttcttgaa     2880

atagtttatc ttgtaatgaa atataaggca cctcccactt ttatgtatag aaagaggtct     2940

tttaattttt ttttaatgtg agaaggaagg gaggagtagg aatcttgaga ttccagatcg     3000

aaaatactgt actttggttg atttttaagt gggcttccat tccatggatt taatcagtcc     3060

caagaagatc aaactcagca gtacttgggt gctgaagaac tgttggattt accctggcac     3120

gtgtgccact tgccagcttc ttgggcacac agagttcttc aatccaagtt atcagattgt     3180

atttgaaaat gacagagctg gagagttttt tgaaatggca gtggcaaata aataaatact     3240

tttttttaaa tggaaagact tgatctatgg taataaatga ttttgttttc tgactggaaa     3300

aataggccta ctaaagatga atcacacttg agatgtttct tactcactct gcacagaaac     3360

aaagaagaaa tgttatacag ggaagtccgt tttcactatt agtatgaacc aagaaatggt     3420

tcaaaaacag tggtaggagc aatgctttca tagtttcaga tatggtagtt atgaagaaaa     3480

caatgtcatt tgctgctatt attgtaagag tcttataatt aatggtactc ctataatttt     3540

tgattgtgag ctcacctatt tgggttaagc atgccaattt aaagagacca agtgtatgta     3600

cattatgttc tacatattca gtgataaaat tactaaacta ctatatgtct gctttaaatt     3660

tgtactttaa tattgtcttt tggtattaag aaagatatgc tttcagaata gatatgcttc     3720

gctttggcaa ggaatttgga tagaacttgc tatttaaaag aggtgtgggg taaatccttg     3780

tataaatctc cagtttagcc ttttttgaaa aagctagact ttcaaatact aatttcactt     3840

caagcagggt acgtttctgg tttgtttgct tgacttcagt cacaatttct tatcagacca     3900

atggctgacc tctttgagat gtcaggctag gcttacctat gtgttctgtg tcatgtgaat     3960

gctgagaagt ttgacagaga tccaacttca gccttgaccc catcagtccc tcgggttaac     4020

taactgagcc accggtcctc atggctattt taatgagggt attgatggtt aaatgcatgt     4080

ctgatccctt atcccagcca tttgcactgc cagctgggaa ctataccaga cctggatact     4140

gatcccaaag tgttaaattc aactacatgc tggagattag agatggtgcc aataaaggac     4200

ccagaaccag gatcttgatt gctatagact tattaataat ccaggtcaaa gagagtgaca     4260

cacactctct caagacctgg ggtgagggag tctgtgttat ctgcaaggcc atttgaggct     4320

cagaaagtct ctctttccta tagatatatg catactttct gacatatagg aatgtatcag     4380

gaatactcaa ccatcacagg catgttccta cctcagggcc tttacatgtc ctgtttactc     4440

tgtctagaat gtccttctgt agatgacctg gcttgcctcg tcacccttca ggtccttgct     4500

caagtgtcat cttctcccct agttaaacta ccccacaccc tgtctgcttt ccttgcttat     4560

ttttctccat agcattttac catctcttac attagacatt tttcttattt atttgtagtt     4620

tataagcttc atgaggcaag taactttgct ttgtttcttg ctgtatctcc agtgcccaga     4680

gcagtgcctg gtatataata aatatttatt gactgagtga a                         4721


<210> 156
<211> 220
<212> PRT
<213> Homo sapiens

<400> 156
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 157
<211> 4317
<212> DNA
<213> Mus musculus

<400> 157
agaccttggc agatgtgact tcagttcaca ccacactctg ccttgctcac agaggagggg       60

ctgcagccct ggccctcatc agaacaatga cactcaggct gctgttcttg gctctcaact      120

tcttctcagt tcaagtaaca gaaaacaaga ttttggtaaa gcagtcgccc ctgcttgtgg      180

tagatagcaa cgaggtcagc ctcagctgca ggtattccta caaccttctc gcaaaggaat      240

tccgggcatc cctgtacaag ggcgtgaaca gcgacgtgga agtctgtgtc gggaatggga      300

attttaccta tcagccccag tttcgctcga atgccgagtt caactgcgac ggggatttcg      360

acaacgaaac agtgacgttc cgtctctgga atctgcacgt caatcacaca gatatttact      420

tctgcaaaat tgagttcatg taccctccgc cttacctaga caacgagagg agcaatggaa      480

ctattattca cataaaagag aaacatcttt gtcatactca gtcatctcct aagctgtttt      540

gggcactggt cgtggttgct ggagtcctgt tttgttatgg cttgctagtg acagtggctc      600

tttgtgttat ctggacaaat agtagaagga acagactcct tcaaagtgac tacatgaaca      660

tgactccccg gaggcctggg ctcactcgaa agccttacca gccctacgcc cctgccagag      720

actttgcagc gtaccgcccc tgacagggac ccctatccag aagcccgccg gctggtaccc      780

gtctacctgc tcatcatcac tgctctggat aggaaaggac agcctcatct tcagccggcc      840

actttggacc tctactgggc caccaatgcc aactatttta gagtgtctag atctaacatc      900

atgatcatct tgagactctg gaatgaatga cagaagcttc tatggcagga taaagtctgt      960

gtggcttgac ccaaactcaa gcttaataca tttattgact tgattgggga agttagagta     1020

gagcaatcaa aaagatcatt cattcagcct tgggaagtca atttgcaggc tcctggatga     1080

gccctgcccc gttttcactt gccagcacat ttcagtcatg tggtgtgata gccaaagatg     1140

ttttggacag agaagaaagg atagaaaaac cttctctttg gctaagttgg tgtttggggt     1200

ggggataggt tagagtatag tacttaacta tttgaaaaat aatgaaaaca cttttttcac     1260

tcatgaaatg agccacttag ctcctaaata gtgttttcct gttagtttag aaagttgtgg     1320

acatattttt ttaatgattt ctgaccattt ttaatcacat tgactcatgg aatggcctca     1380

aagcaccccc cagtgcttct ttcctcattc ccggtcatgg gaactcagta ttattaatag     1440

tcacaacatg atttcagaac tagatagccc tcccacacca agaagaatgt gagaggaagt     1500

aaggtcactt tatgtaaaaa aaaaaaaaaa caaacgcgta cacatatgta tgtatacata     1560

catacctatg tgcacacaca cacacatata catacacaca aaatgctatg aagagttatc     1620

tgtttagtag cctgttatag tcaaatcatt ttaagtttca acttcttaca gttgggccac     1680

ttgttgtcct ttgtggatgg atatctgaaa ttgtgtctat atattgctag tcatgatact     1740

gtgaacaaaa agggtagtgt tagtatttgt cagggtggta aggatgcatt ccaggaagct     1800

tcctctgagg aagggaatga ggtcattctt gccatgtatg aaagacatag atgttttcca     1860

gaaggcacca ttgggagccc cagtataagt tcctttagac tctacagttt agagggattt     1920

tatatgtcct aggactcagg actccagaac tttgtgggct cagctgcttc ataccatggg     1980

gatacattga catgaacaat tattttggaa tgtgtcttta gggacgacat caaagttctc     2040

aagtacctac aagacctgat actggaatga aggtggactt tcttttttgc ttccagttcg     2100

gatcaactgg aatgtatctg gggaccttga agaacggctg tccagctgtc ttcaccattt     2160

gtatagtgct ttgaattatt cagaggtttt aaagtcagga agacctggtt taaaaaacat     2220

ttcattatga gttaaatggc ctcaggcaag tcactgttca tccaagtcta tgactcctca     2280

actgtaagat ggccacactg aaacttgcta agatcctctg gcctctgcct cccaagagtt     2340

gggatttcag gagtgcacaa tcatgaccca aactcgtgat aatctctcag cttcaataac     2400

tttccagcta attggaatat cctgtaatca aacatgaggc atttcccctc cccccactgt     2460

ttttgtgtat aaagagatct ttaaactttt tttttaatat gaggggtaag aaaagatagg     2520

aatcttttaa ttctagacag aagatattgt gctttggttt tttttttttt taatggcttc     2580

tattctgtgc ttttaattaa accagagaag gccaagatta gccctacttg tgtgataaaa     2640

gaatgctggc ccttgtgatt gcagtcagcc tcttgacaca tagagttctt gaatctaagt     2700

tataaaatta tatttgaaaa tgacagagct ggagaattta tagaaagggt catagcaaat     2760

aacaaaccat ttttttttaa acggaaagat ttggtctttg gcaatcaata actttgtttt     2820

ctaactggaa aaggaggttt actggagatg aatcacacct gaaagttttc atacctcctc     2880

tgaacacaac cgaaacatag gtgtccaaag cctttcgctc tcggtatgaa ccaacaggcg     2940

ggttaaaaac actgggtcag agtaaagctt ttgcagtttc agatgtagtg tgtatgaaga     3000

aaactatgtc acttgctgct attattgtaa gagtctaaga actaaaggtg tgcctgtaat     3060

ttctaattat gagctcacct atttggtacc gagcatgcca attttaaaga gacccggtgt     3120

accttatagc tacatccaat gataaaatta ccacactagc acatgcctgt gtttaaactc     3180

gtgctttaat gtttttctta gggcaggtat gcaccccctt tgcagtgagt tgggagagat     3240

tttgaaaaag tgtatgacaa acatttttaa cacctttggt ttcctctctc tgtgtctctt     3300

tgtctctgtc tctctctttc tctcctgtgc atatgtctcc cctccctcac ttctctgtct     3360

cttcctctct ccctctctct gtctttctct gtgtgtctct ctgtctctgt gtatctctct     3420

gtctgtctct ttctctgcag attttcaaaa cgttgttttt ctatggaaga aatacaagct     3480

gtggttggtt tgctacgagt cagtagcagt ttatcagtag gccaatgttt tatctcttgg     3540

agatttcagt ctgggtttac ccaatgtatt ctctgtaatg tgactgctgg ggacagatat     3600

aacttgattg agccttcaaa tcatttaggt cttcaatcat ttagtcaacg gagtgagcca     3660

ctaatctgca atggctattt taatatgcat actgatggtc aaatggatgt ctgatctctc     3720

atcccagctt tctgtactac catatgggaa ctatatgtaa cttgtatact tacctgaata     3780

tgttaaattc aactacatgg taagatggac cagaaattgc aatgttcatg tccatatagc     3840

caccattaac ccaagttaag cacagtagtg tgggttctct caggacttgt gaatgagttt     3900

atgctctcta caaagacagg tgaagcttaa atctctcttg cactgctatg tttatgcaaa     3960

tatcaagatt gtttctgtac cagggactta acacattcta ttcatactat tttccctgtc     4020

tacaatgtta tttcatagat atctacttgg tttgctctta cttccttgac atatttgccc     4080

aaatgccacc ttcaactgta gttaattacc tgtacaacct gtctccatgc cttgttttat     4140

tttctctata actctactaa taggtatttt tcttatttat tggtttattg cctgtttttt     4200

ttcctaaatc tacaccggat ctccaaaggg aaagaactcc atttgctttg attttattgc     4260

tgtatcccca gtgcctagaa taatgcttag cctgcaataa atatttattc attgact        4317


<210> 158
<211> 218
<212> PRT
<213> Mus musculus

<400> 158
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210> 159
<211> 1282
<212> DNA
<213> Homo sapiens

<400> 159
ggaagtctgt caactgggag ggggagaggg gggtgatggg ccaggaatgg ggtccccggg       60

catggtgctg ggcctcctgg tgcagatctg ggccctgcaa gaagcctcaa gcctgagcgt      120

gcagcagggg cccaacttgc tgcaggtgag gcagggcagt caggcgaccc tggtctgcca      180

ggtggaccag gccacagcct gggaacggct ccgtgttaag tggacaaagg atggggccat      240

cctgtgtcaa ccgtacatca ccaacggcag cctcagcctg ggggtctgcg ggccccaggg      300

acggctctcc tggcaggcac ccagccatct caccctgcag ctggaccctg tgagcctcaa      360

ccacagcggg gcgtacgtgt gctgggcggc cgtagagatt cctgagttgg aggaggctga      420

gggcaacata acaaggctct ttgtggaccc agatgacccc acacagaaca gaaaccggat      480

cgcaagcttc ccaggattcc tcttcgtgct gctgggggtg ggaagcatgg gtgtggctgc      540

gatcgtgtgg ggtgcctggt tctggggccg ccgcagctgc cagcaaaggg actcaggtaa      600

cagcccagga aatgcattct acagcaacgt cctataccgg ccccgggggg ccccaaagaa      660

gagtgaggac tgctctggag aggggaagga ccagaggggc cagagcattt attcaacctc      720

cttcccgcaa ccggcccccc gccagccgca cctggcgtca agaccctgcc ccagcccgag      780

accctgcccc agccccaggc ccggccaccc cgtctctatg gtcagggtct ctcctagacc      840

aagccccacc cagcagccga ggccaaaagg gttccccaaa gtgggagagg agtgagagat      900

cccaggagac ctcaacagga ccccacccat aggtacacac aaaaaagggg ggatcgaggc      960

cagacacggt ggctcacgcc tgtaatccca gcagtttggg aagccgaggc gggtggaaca     1020

cttgaggtca ggggtttgag accagcctgg cttgaacctg ggaggcggag gttgcagtga     1080

gccgagattg cgccactgca ctccagcctg ggcgacagag tgagactccg tctcaaaaaa     1140

aacaaaaagc aggaggattg ggagcctgtc agccccatcc tgagaccccg tcctcatttc     1200

tgtaatgatg gatctcgctc ccactttccc ccaagaacct aataaaggct tgtgaagaaa     1260

aagcaaaaaa aaaaaaaaaa aa                                              1282


<210> 160
<211> 282
<212> PRT
<213> Homo sapiens

<400> 160
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
        275                 280         


<210> 161
<211> 1643
<212> DNA
<213> Homo sapiens

<400> 161
agtctcactt cagttccttt tgcatgaaga gctcagaatc aaaagaggaa accaacccct       60

aagatgagct ttccatgtaa atttgtagcc agcttccttc tgattttcaa tgtttcttcc      120

aaaggtgcag tctccaaaga gattacgaat gccttggaaa cctggggtgc cttgggtcag      180

gacatcaact tggacattcc tagttttcaa atgagtgatg atattgacga tataaaatgg      240

gaaaaaactt cagacaagaa aaagattgca caattcagaa aagagaaaga gactttcaag      300

gaaaaagata catataagct atttaaaaat ggaactctga aaattaagca tctgaagacc      360

gatgatcagg atatctacaa ggtatcaata tatgatacaa aaggaaaaaa tgtgttggaa      420

aaaatatttg atttgaagat tcaagagagg gtctcaaaac caaagatctc ctggacttgt      480

atcaacacaa ccctgacctg tgaggtaatg aatggaactg accccgaatt aaacctgtat      540

caagatggga aacatctaaa actttctcag agggtcatca cacacaagtg gaccaccagc      600

ctgagtgcaa aattcaagtg cacagcaggg aacaaagtca gcaaggaatc cagtgtcgag      660

cctgtcagct gtccaggagg cagcatcctt ggccagagta atgggctctc tgcctggacc      720

cctcccagcc atcccacttc tcttcctttt gcagagaaag gtctggacat ctatctcatc      780

attggcatat gtggaggagg cagcctcttg atggtctttg tggcactgct cgttttctat      840

atcaccaaaa ggaaaaaaca gaggagtcgg agaaatgatg aggagctgga gacaagagcc      900

cacagagtag ctactgaaga aaggggccgg aagccccacc aaattccagc ttcaacccct      960

cagaatccag caacttccca acatcctcct ccaccacctg gtcatcgttc ccaggcacct     1020

agtcatcgtc ccccgcctcc tggacaccgt gttcagcacc agcctcagaa gaggcctcct     1080

gctccgtcgg gcacacaagt tcaccagcag aaaggcccgc ccctccccag acctcgagtt     1140

cagccaaaac ctccccatgg ggcagcagaa aactcattgt ccccttcctc taattaaaaa     1200

agatagaaac tgtctttttc aataaaaagc actgtggatt tctgccctcc tgatgtgcat     1260

atccgtactt ccatgaggtg ttttctgtgt gcagaacatt gtcacctcct gaggctgtgg     1320

gccacagcca cctctgcatc ttcgaactca gccatgtggt caacatctgg agtttttggt     1380

ctcctcagag agctccatca caccagtaag gagaagcaat ataagtgtga ttgcaagaat     1440

ggtagaggac cgagcacaga aatcttagag atttcttgtc ccctctcagg tcatgtgtag     1500

atgcgataaa tcaagtgatt ggtgtgcctg ggtctcacta caagcagcct atctgcttaa     1560

gagactctgg agtttcttat gtgccctggt ggacacttgc ccaccatcct gtgagtaaaa     1620

gtgaaataaa agctttgact aga                                             1643


<210> 162
<211> 377
<212> PRT
<213> Homo sapiens

<400> 162
Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Gly Gly Ser Ile 
        195                 200                 205             


Leu Gly Gln Ser Asn Gly Leu Ser Ala Trp Thr Pro Pro Ser His Pro 
    210                 215                 220                 


Thr Ser Leu Pro Phe Ala Glu Lys Gly Leu Asp Ile Tyr Leu Ile Ile 
225                 230                 235                 240 


Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val Ala Leu Leu 
                245                 250                 255     


Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp 
            260                 265                 270         


Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly 
        275                 280                 285             


Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr 
    290                 295                 300                 


Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser 
305                 310                 315                 320 


His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys 
                325                 330                 335     


Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro 
            340                 345                 350         


Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala 
        355                 360                 365             


Glu Asn Ser Leu Ser Pro Ser Ser Asn 
    370                 375         


<210> 163
<211> 1144
<212> DNA
<213> Mus musculus

<400> 163
gcctcaccac agtcctgaca gaaagaactc agagtcaccc ctgggaaaag aactctaaag       60

atgaaatgta aattcctggg tagcttcttt ctgctcttca gcctttccgg caaaggggcg      120

gactgcagag acaatgagac catctggggt gtcttgggtc atggcatcac cctgaacatc      180

cccaactttc aaatgactga tgatattgat gaggtgcgat gggtaaggag gggcaccctg      240

gtcgcagagt ttaaaaggaa gaagccacct tttttgatat cagaaacgta tgaggtctta      300

gcaaacggat ccctgaagat aaagaagccg atgatgagaa acgacagtgg cacctataat      360

gtaatggtgt atggcacaaa tgggatgact aggctggaga aggacctgga cgtgaggatt      420

ctggagaggg tctcaaagcc catgatccac tgggaatgcc ccaacacaac cctgacctgt      480

gcggtcttgc aagggacaga ttttgaactg aagctgtatc aaggggaaac actactcaat      540

agtctccccc agaagaacat gagttaccag tggaccaacc tgaacgcacc attcaagtgt      600

gaggcgataa acccggtcag caaggagtct aagatggaag ttgttaactg tccagagaaa      660

ggtctgtcct tctatgtcac agtgggggtc ggtgcaggag gactcctctt ggtgctcttg      720

gtggcgcttt ttattttctg tatctgcaag aggagaaaac ggaacaggag gagaaaagat      780

gaagagctgg aaataaaagc ttccagaaca agcactgtgg aaaggggccc caagccgcac      840

tcaaccccag ccgcagcagc gcagaattca gtggcgctcc aagctcctcc tccacctggc      900

catcacctcc agacacctgg ccatcgtccc ttgcctccag gccaccgtac ccgtgagcac      960

cagcagaaga agagacctcc tccatcaggc acacagattc accagcagaa aggccctcct     1020

ttacccagac cccgagttca gccaaaacct ccctgtggga gtggagatgg tgtttcactg     1080

ccgcccccta attaagaagg cagagttcgt catttccaat aaaaagctgt gtggatttat     1140

cttc                                                                  1144


<210> 164
<211> 344
<212> PRT
<213> Mus musculus

<400> 164
Met Lys Cys Lys Phe Leu Gly Ser Phe Phe Leu Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gly Lys Gly Ala Asp Cys Arg Asp Asn Glu Thr Ile Trp Gly Val Leu 
            20                  25                  30          


Gly His Gly Ile Thr Leu Asn Ile Pro Asn Phe Gln Met Thr Asp Asp 
        35                  40                  45              


Ile Asp Glu Val Arg Trp Val Arg Arg Gly Thr Leu Val Ala Glu Phe 
    50                  55                  60                  


Lys Arg Lys Lys Pro Pro Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu 
65                  70                  75                  80  


Ala Asn Gly Ser Leu Lys Ile Lys Lys Pro Met Met Arg Asn Asp Ser 
                85                  90                  95      


Gly Thr Tyr Asn Val Met Val Tyr Gly Thr Asn Gly Met Thr Arg Leu 
            100                 105                 110         


Glu Lys Asp Leu Asp Val Arg Ile Leu Glu Arg Val Ser Lys Pro Met 
        115                 120                 125             


Ile His Trp Glu Cys Pro Asn Thr Thr Leu Thr Cys Ala Val Leu Gln 
    130                 135                 140                 


Gly Thr Asp Phe Glu Leu Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn 
145                 150                 155                 160 


Ser Leu Pro Gln Lys Asn Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala 
                165                 170                 175     


Pro Phe Lys Cys Glu Ala Ile Asn Pro Val Ser Lys Glu Ser Lys Met 
            180                 185                 190         


Glu Val Val Asn Cys Pro Glu Lys Gly Leu Ser Phe Tyr Val Thr Val 
        195                 200                 205             


Gly Val Gly Ala Gly Gly Leu Leu Leu Val Leu Leu Val Ala Leu Phe 
    210                 215                 220                 


Ile Phe Cys Ile Cys Lys Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp 
225                 230                 235                 240 


Glu Glu Leu Glu Ile Lys Ala Ser Arg Thr Ser Thr Val Glu Arg Gly 
                245                 250                 255     


Pro Lys Pro His Ser Thr Pro Ala Ala Ala Ala Gln Asn Ser Val Ala 
            260                 265                 270         


Leu Gln Ala Pro Pro Pro Pro Gly His His Leu Gln Thr Pro Gly His 
        275                 280                 285             


Arg Pro Leu Pro Pro Gly His Arg Thr Arg Glu His Gln Gln Lys Lys 
    290                 295                 300                 


Arg Pro Pro Pro Ser Gly Thr Gln Ile His Gln Gln Lys Gly Pro Pro 
305                 310                 315                 320 


Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp 
                325                 330                 335     


Gly Val Ser Leu Pro Pro Pro Asn 
            340                 


<210> 165
<211> 1086
<212> DNA
<213> Homo sapiens

<400> 165
gaacttaggg ctgcttgtgg ctgggcactc gcgcagaggc cggcccgacg agccatggtt       60

gctgggagcg acgcggggcg ggccctgggg gtcctcagcg tggtctgcct gctgcactgc      120

tttggtttca tcagctgttt ttcccaacaa atatatggtg ttgtgtatgg gaatgtaact      180

ttccatgtac caagcaatgt gcctttaaaa gaggtcctat ggaaaaaaca aaaggataaa      240

gttgcagaac tggaaaattc tgaattcaga gctttctcat cttttaaaaa tagggtttat      300

ttagacactg tgtcaggtag cctcactatc tacaacttaa catcatcaga tgaagatgag      360

tatgaaatgg aatcgccaaa tattactgat accatgaagt tctttcttta tgtgcttgag      420

tctcttccat ctcccacact aacttgtgca ttgactaatg gaagcattga agtccaatgc      480

atgataccag agcattacaa cagccatcga ggacttataa tgtactcatg ggattgtcct      540

atggagcaat gtaaacgtaa ctcaaccagt atatatttta agatggaaaa tgatcttcca      600

caaaaaatac agtgtactct tagcaatcca ttatttaata caacatcatc aatcattttg      660

acaacctgta tcccaagcag cggtcattca agacacagat atgcacttat acccatacca      720

ttagcagtaa ttacaacatg tattgtgctg tatatgaatg gtattctgaa atgtgacaga      780

aaaccagaca gaaccaactc caattgattg gtaacagaag atgaagacaa cagcataact      840

aaattatttt aaaaactaaa aagccatctg atttctcatt tgagtattac aatttttgaa      900

caactgttgg aaatgtaact tgaagcagct gctttaagaa gaaataccca ctaacaaaga      960

acaagcatta gttttggctg tcatcaactt attatatgac taggtgcttg ctttttttgt     1020

cagtaaattg tttttactga tgatgtagat acttttgtaa ataaatgtaa atatgtacac     1080

aagtga                                                                1086


<210> 166
<211> 250
<212> PRT
<213> Homo sapiens

<400> 166
Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210> 167
<211> 1097
<212> DNA
<213> Homo sapiens

<400> 167
ctttttctag ccaggctctc aactgtctcc tgcgttgctg ggaagttctg gaaggaagca       60

tgtgctccag aggttgggat tcgtgtctgg ctctggaatt gctactgctg cctctgtcac      120

tcctggtgac cagcattcaa ggtcacttgg tacatatgac cgtggtctcc ggcagcaacg      180

tgactctgaa catctctgag agcctgcctg agaactacaa acaactaacc tggttttata      240

ctttcgacca gaagattgta gaatgggatt ccagaaaatc taagtacttt gaatccaaat      300

ttaaaggcag ggtcagactt gatcctcaga gtggcgcact gtacatctct aaggtccaga      360

aagaggacaa cagcacctac atcatgaggg tgttgaaaaa gactgggaat gagcaagaat      420

ggaagatcaa gctgcaagtg cttgaccctg tacccaagcc tgtcatcaaa attgagaaga      480

tagaagacat ggatgacaac tgttatctga aactgtcatg tgtgatacct ggcgagtctg      540

taaactacac ctggtatggg gacaaaaggc ccttcccaaa ggagctccag aacagtgtgc      600

ttgaaaccac ccttatgcca cataattact ccaggtgtta tacttgccaa gtcagcaatt      660

ctgtgagcag caagaatggc acggtctgcc tcagtccacc ctgtaccctg gcccggtcct      720

ttggagtaga atggattgca agttggctag tggtcacggt gcccaccatt cttggcctgt      780

tacttacctg agatgagctc ttttaactca agcgaaactt caaggccaga agatcttgcc      840

tgttggtgat catgctcctc accaggacag agactgtata ggctgaccag aagcatgctg      900

ctgaattatc aacgaggatt ttcaagttaa cttttaaata ctggttatta tttaatttta      960

tatccctttg ttgttttcta gtacacagag atatagagat acacatgctt ttttcccacc     1020

caaaattgtg acaacattat gtgaatgttt tattattttt taaaataaac atttgatata     1080

attgtcaatt aactgaa                                                    1097


<210> 168
<211> 243
<212> PRT
<213> Homo sapiens

<400> 168
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210> 169
<211> 1205
<212> DNA
<213> Mus musculus

<400> 169
atacgacttc cggttttggg ttttgcttcc tgattgaagg gcaggcgccc tgacttctct       60

tacagttgtc tccagtgttc tggggaagct tctctaagta ttatgtgctt cataaaacag      120

ggatggtgtc tggtcctgga actgctactg ctgcccttgg gaactggatt tcaaggtcat      180

tcaataccag atataaatgc caccaccggc agcaatgtaa ccctgaaaat ccataaggac      240

ccacttggac catataaacg tatcacctgg cttcatacta aaaatcagaa gattttagag      300

tacaactata atagtacaaa gacaatcttc gagtctgaat ttaaaggcag ggtttatctt      360

gaagaaaaca atggtgcact tcatatctct aatgtccgga aagaggacaa aggtacctac      420

tacatgagag tgctgcgtga aactgagaac gagttgaaga taaccctgga agtatttgat      480

cctgtgccca agccttccat agaaatcaat aagactgaag cgtcgactga ttcctgtcac      540

ctgaggctat cgtgtgaggt aaaggaccag catgttgact atacttggta tgagagctcg      600

ggacctttcc ccaaaaagag tccaggatat gtgctcgatc tcatcgtcac accacagaac      660

aagtctacat tttacacctg ccaagtcagc aatcctgtaa gcagcaagaa cgacacagtg      720

tacttcactc taccttgtga tctagccaga tcttctggag tatgttggac tgcaacttgg      780

ctagtggtca caacactcat cattcacagg atcctgttaa cctgacaaga actcttctca      840

cccaagaagg caacttggaa gcacagagtc ttgccttcat ccctagcagt gttcctagcc      900

agcgaagcaa ctctggctct attggacaaa ggaaaatgtg ttactgaacg tctgcgagag      960

tttgcatgca tgctctatga aacaagcaca ggaccttgta cagtgctcca ccactgacct     1020

gtgtgcccag tcctttacaa agatttcaaa tcaacctttt aaaaactgtg cataatatct     1080

aattttatat accctagttg tttcccaaca tatattaaag ataaatgcat tctttttacc     1140

aaaatgtgac tatattattt tcatgttttc atatctcttt ttaaaataaa ttcttttaaa     1200

aaact                                                                 1205


<210> 170
<211> 240
<212> PRT
<213> Mus musculus

<400> 170
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Asp Pro Val 
        115                 120                 125             


Pro Lys Pro Ser Ile Glu Ile Asn Lys Thr Glu Ala Ser Thr Asp Ser 
    130                 135                 140                 


Cys His Leu Arg Leu Ser Cys Glu Val Lys Asp Gln His Val Asp Tyr 
145                 150                 155                 160 


Thr Trp Tyr Glu Ser Ser Gly Pro Phe Pro Lys Lys Ser Pro Gly Tyr 
                165                 170                 175     


Val Leu Asp Leu Ile Val Thr Pro Gln Asn Lys Ser Thr Phe Tyr Thr 
            180                 185                 190         


Cys Gln Val Ser Asn Pro Val Ser Ser Lys Asn Asp Thr Val Tyr Phe 
        195                 200                 205             


Thr Leu Pro Cys Asp Leu Ala Arg Ser Ser Gly Val Cys Trp Thr Ala 
    210                 215                 220                 


Thr Trp Leu Val Val Thr Thr Leu Ile Ile His Arg Ile Leu Leu Thr 
225                 230                 235                 240 


<210> 171
<211> 12123
<212> DNA
<213> Homo sapiens

<400> 171
gcagatggga agaagcgtta gagcgagcag cactcacatc tcaagaacca gcctttcaaa       60

cagtttccag agatggatta tcctacttta cttttggctc ttcttcatgt atacagagct      120

ctatgtgaag aggtgctttg gcatacatca gttccctttg ccgagaacat gtctctagaa      180

tgtgtgtatc catcaatggg catcttaaca caggtggagt ggttcaagat cgggacccag      240

caggattcca tagccatttt cagccctact catggcatgg tcataaggaa gccctatgct      300

gagagggttt actttttgaa ttcaacgatg gcttccaata acatgactct tttctttcgg      360

aatgcctctg aagatgatgt tggctactat tcctgctctc tttacactta cccacaggga      420

acttggcaga aggtgataca ggtggttcag tcagatagtt ttgaggcagc tgtgccatca      480

aatagccaca ttgtttcgga acctggaaag aatgtcacac tcacttgtca gcctcagatg      540

acgtggcctg tgcaggcagt gaggtgggaa aagatccagc cccgtcagat cgacctctta      600

acttactgca acttggtcca tggcagaaat ttcacctcca agttcccaag acaaatagtg      660

agcaactgca gccacggaag gtggagcgtc atcgtcatcc ccgatgtcac agtctcagac      720

tcggggcttt accgctgcta cttgcaggcc agcgcaggag aaaacgaaac cttcgtgatg      780

agattgactg tagccgaggg taaaaccgat aaccaatata ccctctttgt ggctggaggg      840

acagttttat tgttgttgtt tgttatctca attaccacca tcattgtcat tttccttaac      900

agaaggagaa ggagagagag aagagatcta tttacagagt cctgggatac acagaaggca      960

cccaataact atagaagtcc catctctacc agtcaaccta ccaatcaatc catggatgat     1020

acaagagagg atatttatgt caactatcca accttctctc gcagaccaaa gactagagtt     1080

taagcttatt cttgacatga gtgcattagt aatgactctt atgtactcat gcatggatct     1140

ttatgcaatt tttttccact acccaaggtc taccttagat actagttgtc tgaattgagt     1200

tactttgata ggaaaaatac ttcattacct aaaatcattt ttcatagaac tgtttcagaa     1260

aacctgactc taactggttt atatacaaaa gaaaacttac tgtatcatat aacagaatga     1320

tccaggggag attaagcttt gggcaagggc tatttaccag ggcttaaatg ttgtgtctag     1380

aattaagtat gggcataaac tggcttctga atccctttcc agagtgttgg atccatttcc     1440

ctggtcttgg cctcactctc atgcaggctt tcctcttgtg ttggcaagat ggctgccaac     1500

tcttggcaat tcatacatcc ttgtttctgt ctggtagaga gtttgcttct caaatggagc     1560

aaacaaattt gattattttt tcattgttaa ataggcaaca tgaccagaaa ggatggaatg     1620

gcttaagtaa actaagggtt cacttctaga gctgagaagc agggtcaaag cacaatactg     1680

ggcaattcag agcatggtta gaagaggaaa ggggagtctc aaagctggag agtttaccaa     1740

caaatattga ctgcagtgat taaccaagac atttttgtta actaaaaagt gaaatatggg     1800

atggattcta gaaatggggt atctctgtcc atacttctag aatccactct atcagcatag     1860

tccagaagaa tacctggcag tagaagaaat gaatattcaa gaggaagata aatgcgagag     1920

ggcaatcctt tactattctc atatttattt atctctcatt ctgtatagaa ttcttgccgc     1980

catcccaggt ctagccttag gagcaaatgt agtagatagt cgaataataa ataacttaat     2040

gttttggaca tattttgtct acttttgaga attattttta atatgtaaat tctctcaaaa     2100

gggtcaggca cctagttatt attttttaat gattatgtga aagttgaata taatatacca     2160

ctaaaagtga cagttgaaag tggtggcata ggacggtagg gtagaaattt gggagggaaa     2220

aaagaaattg ggagggtaca ggcaacagga gaaaggaatc aaaccacaga aaaatacaaa     2280

gggaaacttc tgcttcacta ttcagacaaa gacagcccta atgacatcac caacagtcaa     2340

agcaattaga gaccatacct aatattgttt aaattctaga tgtaggctaa caatgaaaag     2400

tatttgccaa actgaataaa actgtcatgg ttaccttgaa aggacaatgg ttattgttaa     2460

atatagtgat cattcatgtc taaaagattc attatttatc tctaaagatt tctaaagacc     2520

accatctaga aaagattcat tatgaaggct gtatttaaat atcaaagttg tggacttcat     2580

gataatctta aataaagcaa atccaaattc tcctgttgcc tagacagatt ctaagatgta     2640

atttacactt ttaagctaat tagtgagtat tttatgattt tagccttaaa caccatgtat     2700

gccaaataat gcacttgttt tgtgaattac agaaatggta agtgcccaca tttctgtgaa     2760

ttataaaatt tgtgagtttc ttttaaccct tttcaggagt gaaaaaataa aaacgaccat     2820

ttcctggttg tgcttaagta tatgcaagaa gggtaaactc tcatttttat tatgtttgct     2880

taaagatctt tttatacctg gattcatgaa atgtttccac aaatatatta gtgtaacaaa     2940

cttgaaaggc agtttacaag aaagcactct actatcagat caatcaaaga ttctgtgagt     3000

gaatttattg gtttgcatgg tgaagcaagc ttagcatcaa ttaaaaggta aataatttct     3060

tttctgaatg gtaaagacaa tcaaaatatt actttctgga aaactccaat aaccaaattc     3120

tcaatgatta gtgtatgtga gcaggaaaac atttttacag ttgtagtatg gggaaatata     3180

aatccaattt taagagagaa aattatgact gggtgtggaa gggacagtat agtcagatac     3240

cattgtcatg gtggttttta ctgggaactt catgaaagac ttttgtagca aaccactgca     3300

gtattgcaaa gcctccagaa catttggaac ttgtctcttt ttccttgtgt gtgtttgtgt     3360

ttttggtctc tcattcaaaa tattgatgag aactatttac tctgtccttt cttctctata     3420

tattcttcct ctacagagtg tagggttttt tcaggaattt ggagccatct gaagtcctcc     3480

caaaaattct ctgacgtctt ctgatgctcc tgttataccc tcaggggtaa tgcttgtgaa     3540

attccattca ttcattttct ttctctggac atctttactt accaaagcac tttcattgtc     3600

atctttttaa catcattctt aattcgtgat agttttggga ctctccctag tgtatgtttc     3660

tccccctcta ctcttttgca cctatgattc tgattgttac taagaaagca gatgaaaaac     3720

agatccacag aataaacgat cagaattcca gtaaattcta ttttaaatac agatactttt     3780

tacaagttgc tgctttggaa gcaaaatgct tcttaagttt tacatatata tatatatata     3840

tacatatata tatacacata taatttatat cgatggataa tacattaaga atctatgctt     3900

cctttgaatg ccattaatat ttatgttaaa gtaaccaatg aaaggaaatt actttgttat     3960

aataagatag gaagacttgt taatggagta cacagttttg tcagggaaag aacacatctt     4020

attgaactat gatgactatg cattgactat attattataa gagatacctt caaactttat     4080

ttaaagaact ttaggtataa tatgttgaga aaataaaata gaaatttcat ttacttgtaa     4140

tcatgcttaa aatgggaggc aggtaggtga agatataatt tttagtaaaa actccaattt     4200

atgttttaag taattcagtg tattactaaa atactatata tataaactta aaatacatgg     4260

gttatcaatt taaaagacaa agtaagtaaa aatactttta gtaggcattc gtggattgtg     4320

aacatccaag ttatattggt ttgtatagaa tggcattaag taaaaattac agctgtataa     4380

cagtagtttt ctaaattgag agagtccaca ttgtaattag agatcactgt gaccaaaatg     4440

cttctccttg atttataatg atgtactgta ttttgtactg cttatatgaa atttcagcaa     4500

gattgacgat attataaaga tgcttataaa gtgtaagtgg agacgctaaa ttgtgagtac     4560

aaagtttctt tttcacaaca gtgataagaa aatatcttta aaaaatataa gacaatataa     4620

acatgtcatc attagtttag ctactattaa aatgtaacat ctagaaagta ctgatctcca     4680

ccttcagact tctgtataag tatatttttt cactgatctg ttcattagag ttcttccagc     4740

caagactctg ggctcttaaa acatgtatct gaaaactaaa aacaagttaa tttttttaaa     4800

agcttctcta tttctagtga ttcaataggt agaaaaatag cttctagaat taactgcaat     4860

gctttctaag gaaattttat aaatcctcaa ggtcggttta cacatatttt tccagattca     4920

gagcactaac tatcttgtaa gatgtaagaa aaggtccatt tggaagtatg agtaataaat     4980

gtctgggata attctggttt atttcgtatt atccttgtta gaataagtta tatggtcaac     5040

ctgttcagaa cactttttct agtgttagtg tgtacttttg gatttttggt tcttgtaggg     5100

tatagaaata ttttcctttg tcttgtattc tgttgttttg aatgaataaa acacaatgtt     5160

tcacgatcac tactttcatt tgccatggag aaatagcagg gaaaaatttc tacagaataa     5220

aattaactga tgaattacat gcagaaaaaa ttcaaatcaa tgatacattg taatttttat     5280

ctcaatgcaa tgttctttgt attttatttt attattattt ttttgagacg gagtttcact     5340

tttgttgccc gggctggagt gcaatggcac aatctcggct caccacaacc tctgcctccc     5400

ggattcaagt gattctcctg cctcagcctc ctgaatagct gggattacag gcatatgcca     5460

acatgcctgg ctaattttgt atttttagtg gagacggggt ttctccacgt tggtcagact     5520

tgtcttgaac tctggacctc aggtgatcca cctgcctcag cctcctaaat tgctgggatt     5580

acaggcatga gcgaccactc ctggccttgt tctttgtatt ttataagtgc atgtagtgca     5640

aagggtcaaa gggctttaca ggttttttgt ttgtttgttt ttgtttttcc cgaaacatag     5700

tagtcccttg cccttcctca tttttgttac cttgagacaa caaattttac tacttctaac     5760

tcattatttt atttatgttc acttttctga atagcatgct tatgacacta atactttttt     5820

tttcaatttt agacattcat tattcattta gatgtctttc tctccccaaa ctcaccacat     5880

aaaatactct tctcatgtct ctttcagaaa tatttgtatt aaaatatgat tatatcaata     5940

tttggcattt atttcttatg accttgccag tactcttagt taaactacat ggtaaaaatg     6000

attttgcttt ccctcctaca taactttttt tccacctaga gctaataatt gtcattctgg     6060

ggactgactt tttctgtatt taccataaat tgacctgaaa ctcccctgtg atgcagcagg     6120

aattctacca acgtcaactt ccttagaaag actccattag aagcttgact tggggctaga     6180

aggagaggca cacaactgcc atcctggtgt ctcccttcat ccagaaaaag ggggaggaat     6240

acatgaaacc tagaatccac tctaaaacat tttccagaac aaaaggacat gtgtttccgt     6300

gttgtaaatg tttaacgagt gcccataaca aggaataata agtctattat gtttgctttt     6360

gtgtctgtaa aagttggggg tattggttgt aagcacgaaa acagatactg actgttgaag     6420

aaaaaaaaaa atacgaggtc aggagtttga gaccaacttg gccaatatgg tgaaaccctg     6480

tcttagtaaa aatagaaaaa ttagccaggc ctggtggcac gcacctgtag tcccagctac     6540

ttgggaggct gaggcagaag aatcgcttga acccgggagg cagaggttgc agtgagccaa     6600

gatcgcacca ctgcactcca ccctgggcaa cagagcgaga ctccgtctca aaaaaaaaaa     6660

aaaaaaaaaa aaaaaaaagt taagtatttg aacatagggg tggctcatag aattcccagg     6720

acacccgatg gagtaggctt gcaaaacaca acatgtggca actccagtgg gaaacgaggc     6780

aggaaacact cgtttcctgc agaaagcaac aatttgggct tcgataccct ccctagaaca     6840

cagggcagtg aatctgagca gcatcagtac cccacgttcg gatgagtcct gagcccctat     6900

ttttattcac tgacttattc caaaatcagt gtctcttaaa tatatctgga aggcagcagc     6960

ttgtatctcc cccttcagct tccatagtgg cagtcagggt acaacttact ttccaaacag     7020

aacacactgc gacattccct ccaggctcgt tgaagaactt caactgacaa atgtccctcc     7080

tcgaccagat gatagttttc ttaaaggcag ggtttaatat acccttttat aaatgtttca     7140

aggccctgtg taatacctga gtttattcca gatgtaacta aatatatcca agattgtttt     7200

aaaataaatt gctgaaaaaa caaataaata cagttagtat ctatatcaat attctcagtt     7260

ggcagttttg caataatggc cgatagttca tttttagtaa cactattgac attgcatttg     7320

gatattaggg tttactaatc atccgcatgt atacattgca tatttttcta gactttaact     7380

ttattcaaat ctattgattt ttaaacctgc aacttatgtc tagacacagg tataccttta     7440

caagaactac catttttttt ggtaacatac tacctccaaa atttcaagta agaagttgat     7500

ttttgtccat ttttaaatgg aaaacttgta atcaaaatgc cacaaaatta tactgtgtat     7560

catttgacct atagaaacca atattattac aggaagaaag cagagccaat cttctacctg     7620

tggtcaaata agtggaggcc ctttctagac taagttctca tgagtttaaa ataccaagca     7680

taagttctcc aaattcctga aaaggaagcc ttgtgttgta ttgcccagcc atatttgtaa     7740

gacataaaaa taaaacttga gaagaagcta tgataactta ctttcttcat tcttcaaaat     7800

ttacataatc tcaactgatt ttatgttttt atgaaaatgc attcttaaga tatatcctta     7860

ttcaatcatg tattcattac atcctttatg ccaggtatcc aaaagtactt acagtgacta     7920

agaccattat tctttgatca gctgcctgag taagactttg agctctccaa tatactctca     7980

gtgatactaa gttttctgag taacagcttt ggatgtggct tcagttgagc tgatttatcc     8040

cacactttat ttttatcgta taatggtcct cagaagcaaa ttttgatttt agctcacata     8100

aaaaatgtac aaagaaatgt aatggctcag tagcttctag agatagagat tactcttcta     8160

acctttctgt aattttgtat gtctatttta taattctttc aatgtctaat gaatagctat     8220

ctttttttga gacggagtct cgctctgtcg cccaggctgg agtgcagtgg tgcgacctcg     8280

gctcaccgca agctgcgtct tccaggttca cgccattctc ctgcctcagc ctcccgagta     8340

gctgggactt caggcgccca ccaccatgcc cagctaattt ttttgtattt ttagtagaga     8400

cggggtttca ccgtgttagc cagggtggtc tcgatctcct gacctcgtga tccgcccgcc     8460

tcggcctccc aacgtgctgg gattacagga gtgagccacc gcgcccggcc tccttagttt     8520

cttaaggtgg aagcctagat tattgatttt atatgttgtt ttcttttcca atagtggcac     8580

ttaatgctat aaatttcact ttgttccaca agttttggta agctctattt ttattttcat     8640

ttagtccaaa atattttaaa atttcttttg atatttcttc tttgagccat gaattattta     8700

caatgtgttg tttaatctct atatattttg ggatttttct actttatatc tcttacagat     8760

ttctaactta atttcatcat gttttaaaaa cattctttgt ataatttcta ttcttttaaa     8820

tttttcaggt gtattttatg gcccagaata tggtctatct tgtagaatgt ttcatgtgat     8880

cttaagaaga atgttcattc tgctgttgag tgtaatattc tacaaatgtc cattagatta     8940

aactgattga taccaccgtt cagattatct atatcctttc tgattttccc tcttcttgat     9000

ctatcacata ctgacagatc aagtgatcaa gtctcgttaa agactgcaag taaaatagtg     9060

gatttttcta tttctccttg cagttttgtt agtttttgtc tcatgtatct tgatactctt     9120

gttagtacat atactttcag aatcgttagg ttttcttgga gaattgaccc ctttaccaca     9180

tgtaatgtcc cttttattct tgataatctt tcttgttctg tctgcttttt ctgatattaa     9240

cataactttc agttttttaa aaaattaaca ttagcatctc acatctttat ccttttaatt     9300

ttaaattatc taaatattta tatttaatgt gcctttctta tagacaatgt atagttgcgt     9360

ctatttgtaa tttccccact tttcttactt aaaaatgttg tagatatata ggagttgtat     9420

atatttgggg ggtacatgtg atgttttgat acctgtatac aatatgtaat gatcatattg     9480

ggtaatcgtg atatctgtca cctctaacat tcatcttttt tgtgtgttta aacccaccac     9540

ttctaattgg tacatttaga ttattcaaat ttaagtgatt attgatatag ttggattaat     9600

atctactatg tttgtaactt ttctatcctt gcactcgttc tttctttttt atcctccttt     9660

ttctgtgttc tctgatttta actggggttt ttacatgatt taattttctc tcgtggcata     9720

tctttcattg atcaacctag gtttttctcc ttttcccctc ttttttttgg tatttattct     9780

atttagtgtt atctgagcta cctgagttgg tgtctatcac taattttggc aagttcccag     9840

acgttattac ttctaacatt cttttgctcc attctttctt cttcttcaat tattccatag     9900

tcttgaatat tctgggtttt tcccactctt tgaattttag tttgaaaagt ttctattggc     9960

ctagcttcaa agtcattcat tcttccttcg gggttccaag tcaactgata attgcatcaa    10020

agatatcctt cctttctatt actatgtttt ttattgctac catttctttt ttattccttc    10080

ttagtgtttc catctttctt cttacattat ccatctgttg tctatttttt tcatgagagc    10140

tcttaacata ttaatgataa gttccatgtc tgataattct gacacgtgtc atgtctctat    10200

ctggttccaa tgattgcttt atctcttcag accatgactt ttcttgcctt ttgacgttct    10260

ttgacatttt ttttgaattt tttgttgcaa gccagatctg gtgtgttatg taataggaac    10320

aggtaaataa gtctttagct tgcagactta tcttaatctg actaactatt agactgtgtt    10380

taaagtctgt tataaccata ggtgctaaat ttcttcaaat tcctctagtg tctttgtttt    10440

gtttgttcat gtgtttttcc ccttcttgag ttcaggcttc cctaagtgct cctcttcaga    10500

gagactttct gtctttcagc tctttcctct gcaattcact gttactatac tggagccctg    10560

ttggtgtagt actaagctgt gggaaaggag agtgctctgt aatcttacag tgaaatctca    10620

gtcttttagt gggtctgtgt ctgggacatt cacagagctt ctccagtggt attgcttcct    10680

catcctcaac tctctttcct ggctgcagca ttcccaatgt atttctttga aggcctgccc    10740

cctgttgact gttattttcc ctctttcctt aagtgggaca gggagacttc aggggctggg    10800

atgaggtttg ggaattgtgc ttggcagagt cctttccatc tttgttacca agaaggttca    10860

tggcttattt ctcaatggat gtccctctct atctgttgcc agagccacga ggaaattttt    10920

cttggatcct cataatgaga accttggagt ttcctactgg aaaagccctt gaatgtgtgg    10980

agtgcctcaa gagcacagcc cccatgggtt tcttgctcac accagtccac aaacagatgc    11040

cagcaattca cccaacttac catataaagg ctcatactag tttatggctc cagtgctttg    11100

actccagata aatggctatt ggttgcgtat ctctctggat gtatctgtat ctccagattt    11160

tggggtggca gtttgctcag gaccttggtt ctctaatagg tctaataaga aaagtcattg    11220

attttcagct ttccaacttt ccagctttgt cttgttataa gcatggcagc aacatcttcc    11280

atgccttaac atgatgacac taaaggcaga agtcgatctc catgtataaa cattttaaca    11340

catatgtttt ttgttatcgt ggtttctgac ctgtctcttt gccctgactt tctgatactg    11400

cactagggtt cctgttgctg gactccattc catatgactt gctctcgtct aggctgctct    11460

ttggctcatc tttataaatc atgatccaaa atgaagcaca tatttatttt ttaaataaat    11520

atgaaatgaa gtatagacat caaactgaag atgagtagat catactgagt ttcactgtct    11580

gtgcttggat caacatcagg ccttatacaa atattcaagt ccagaggcaa aaggtaataa    11640

ggaaaatttg tagcacaagc cacaaggaga taacatgtca agtctatgcg attggaaata    11700

aactaaagat gaactgctgg ggatgctcac tcatcacaga gctcagtcta aagcaccaga    11760

tttcacaagc attttttggg ggaaattctg ttaaaatgaa atatgagtca catggtggtg    11820

tttcactcat catatgtgtt caatattaat tcattttaag gtttagttgc acaaaaggta    11880

aatgagaatt agaagactcc atgggtaaga ggagccacag aagtaaagca ttgtcaaggg    11940

ttctatgtct atatatttag atattaggct tctgagaaaa aaacacaata ggaaggaaga    12000

tgaacacaac agagggcaga aggtctatac gtcctgaggc cttttatgca acgtttgttt    12060

gtggaatgtt ttttaagaat gtgtgagagt cattttaatg tgaaataaag acctacgtct    12120

aca                                                                  12123


<210> 172
<211> 336
<212> PRT
<213> Homo sapiens

<400> 172
Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210> 173
<211> 2487
<212> DNA
<213> Mus musculus

<400> 173
acacagaaga cttcttgact tcaggagaca ctgctgtatg aaacagtgct tgctatcagt       60

ggctgctgga agaggctgtg gtggaaagaa aacctcaact gcaggccaga gttggttccc      120

caaaagaggc aaactcccag tgctagccag aggctaggaa gctctaagca acccacttat      180

ctgcaaggag agttacgccc aaagagcatc aagtccaacc tcctgaactg tttccagaga      240

tggcttatgt tacttggctt ttggctattc ttcatgtgca caaagcactg tgtgaagaga      300

cattgtggga cacaacagtt cggctttctg agactatgac tctggaatgt gtatatccat      360

tgacgcataa cttaacccag gtggagtgga ccaagaacac tggcacaaag acagtgagca      420

tagcagttta caaccctaac cataatatgc atatagaatc taactacctc catagagtac      480

acttcctaaa ctcaacagtg gggttccgca acatgagcct ttccttttac aatgcctcag      540

aagcagacat tggcatctac tcctgcttgt ttcatgcttt cccaaatgga ccttgggaaa      600

agaagataaa agtagtctgg tcagatagtt ttgagatagc agcaccctcg gatagctacc      660

tgtctgcaga acctggacaa gatgtcacac tcacttgcca gcttccaagg acttggccag      720

tgcaacaagt catatgggaa aaagtccagc cccatcaggt agacatctta gcttcctgta      780

acctatctca agagacaaga tacacttcaa agtacctaag acaaacaagg agcaactgta      840

gccaggggag catgaagagc atcctcatca ttccaaatgc catggccgct gactcaggac      900

tttacagatg tcgctcagag gccattacag gaaaaaacaa gtcctttgtc ataaggctga      960

tcataactga tggtggaacc aataaacatt ttatccttcc catcgttgga gggttagttt     1020

cactgttact tgtcatccta attatcatca ttttcatttt atataacagg aagagacgga     1080

gacaggtgag aattccactt aaagagccca gggataaaca gagtaaggta gccaccaact     1140

gcagaagtcc tacttctccc atccagtcta cagatgatga aaaagaggac atttatgtaa     1200

actatccaac tttctctcga agaccaaaac caagactcta agctgctctt ttggcctgaa     1260

cacattagtg atgacttcta tggcatggaa ttttacccat gatttcctta ccactaggat     1320

ctacattgat aaaaaaaatt gattaaattt atttcatctc atatatagaa gtactttatt     1380

acctggaaac attcttaata gagattcatt agaaaaccca aatctaatgt tcatgtgttc     1440

aaggaacctt cttccattat gtaacagaac agtctagaga agattaagga ccacatggct     1500

ttcttgctct acttgaaatt aattgtgagc ataagcttgt ttctggagtc ttcttacatt     1560

gttggttcta cttacatact actggtccaa ctctcatgct gtttctctca gatgttccca     1620

tgatggttgc caaggacact tgatagaaag actactggtt aaacacaata aacaaagttc     1680

attattcact tattagcaag aaggtagcat tatcataaag gattagatga cttaagttag     1740

ctataggttc aagacctgga ctaaagtatt acttggaaat tctgagtatt gctaaaaagg     1800

aggatgaaag ggacctagaa gttgagttat tactaaaaac tttgagtgcg aagatattac     1860

tcattaacca gataacaagt gaatatgctg tagcatcaac ataattcaaa agagtaaaga     1920

aatggctagg aatgaggtag ttgtgtaatt atttcttctc ttactagttt caaataaatt     1980

catctctaat tctatagaga attcttgcct cccattcagg actggccttc tatacagtga     2040

gatggtccag taagaaataa tttttattag tgttttttct attttgagaa ttattttaat     2100

atatatttta atatataaac ttgtgagtta aatttttttt ttgcaaaatt agcacatgaa     2160

aagagattga tggttttaag tagtagaaca cagtagtgta ggaatctgag agcagagagt     2220

ttgggagggg gtgaagagaa aacaacatca ccaaatagtg atatataaga gaaaatctgt     2280

gcttcagagt ttgatcaggg ccatctctcc caactctgct ggaactgaga gaatgcacct     2340

gatgttgtct ccattttaga tagagaaaaa aaaaacccga atatttataa aactaaataa     2400

aactatagtt acctcaaaac tatggggatc actataacat agaatagaat agaatagaat     2460

agaatagaat agaatagaat agaatag                                         2487


<210> 174
<211> 333
<212> PRT
<213> Mus musculus

<400> 174
Met Ala Tyr Val Thr Trp Leu Leu Ala Ile Leu His Val His Lys Ala 
1               5                   10                  15      


Leu Cys Glu Glu Thr Leu Trp Asp Thr Thr Val Arg Leu Ser Glu Thr 
            20                  25                  30          


Met Thr Leu Glu Cys Val Tyr Pro Leu Thr His Asn Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Thr Lys Asn Thr Gly Thr Lys Thr Val Ser Ile Ala Val Tyr 
    50                  55                  60                  


Asn Pro Asn His Asn Met His Ile Glu Ser Asn Tyr Leu His Arg Val 
65                  70                  75                  80  


His Phe Leu Asn Ser Thr Val Gly Phe Arg Asn Met Ser Leu Ser Phe 
                85                  90                  95      


Tyr Asn Ala Ser Glu Ala Asp Ile Gly Ile Tyr Ser Cys Leu Phe His 
            100                 105                 110         


Ala Phe Pro Asn Gly Pro Trp Glu Lys Lys Ile Lys Val Val Trp Ser 
        115                 120                 125             


Asp Ser Phe Glu Ile Ala Ala Pro Ser Asp Ser Tyr Leu Ser Ala Glu 
    130                 135                 140                 


Pro Gly Gln Asp Val Thr Leu Thr Cys Gln Leu Pro Arg Thr Trp Pro 
145                 150                 155                 160 


Val Gln Gln Val Ile Trp Glu Lys Val Gln Pro His Gln Val Asp Ile 
                165                 170                 175     


Leu Ala Ser Cys Asn Leu Ser Gln Glu Thr Arg Tyr Thr Ser Lys Tyr 
            180                 185                 190         


Leu Arg Gln Thr Arg Ser Asn Cys Ser Gln Gly Ser Met Lys Ser Ile 
        195                 200                 205             


Leu Ile Ile Pro Asn Ala Met Ala Ala Asp Ser Gly Leu Tyr Arg Cys 
    210                 215                 220                 


Arg Ser Glu Ala Ile Thr Gly Lys Asn Lys Ser Phe Val Ile Arg Leu 
225                 230                 235                 240 


Ile Ile Thr Asp Gly Gly Thr Asn Lys His Phe Ile Leu Pro Ile Val 
                245                 250                 255     


Gly Gly Leu Val Ser Leu Leu Leu Val Ile Leu Ile Ile Ile Ile Phe 
            260                 265                 270         


Ile Leu Tyr Asn Arg Lys Arg Arg Arg Gln Val Arg Ile Pro Leu Lys 
        275                 280                 285             


Glu Pro Arg Asp Lys Gln Ser Lys Val Ala Thr Asn Cys Arg Ser Pro 
    290                 295                 300                 


Thr Ser Pro Ile Gln Ser Thr Asp Asp Glu Lys Glu Asp Ile Tyr Val 
305                 310                 315                 320 


Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Pro Arg Leu 
                325                 330             


<210> 175
<211> 1968
<212> DNA
<213> Homo sapiens

<400> 175
gaaggcggaa ccacgacggg cagagagcac ggagccggga agcccctggg cgcccgtcgg       60

agggctatgg agcagcggcc gcggggctgc gcggcggtgg cggcggcgct cctcctggtg      120

ctgctggggg cccgggccca gggcggcact cgtagcccca ggtgtgactg tgccggtgac      180

ttccacaaga agattggtct gttttgttgc agaggctgcc cagcggggca ctacctgaag      240

gccccttgca cggagccctg cggcaactcc acctgccttg tgtgtcccca agacaccttc      300

ttggcctggg agaaccacca taattctgaa tgtgcccgct gccaggcctg tgatgagcag      360

gcctcccagg tggcgctgga gaactgttca gcagtggccg acacccgctg tggctgtaag      420

ccaggctggt ttgtggagtg ccaggtcagc caatgtgtca gcagttcacc cttctactgc      480

caaccatgcc tagactgcgg ggccctgcac cgccacacac ggctactctg ttcccgcaga      540

gatactgact gtgggacctg cctgcctggc ttctatgaac atggcgatgg ctgcgtgtcc      600

tgccccacga gcaccctggg gagctgtcca gagcgctgtg ccgctgtctg tggctggagg      660

cagatgttct gggtccaggt gctcctggct ggccttgtgg tccccctcct gcttggggcc      720

accctgacct acacataccg ccactgctgg cctcacaagc ccctggttac tgcagatgaa      780

gctgggatgg aggctctgac cccaccaccg gccacccatc tgtcaccctt ggacagcgcc      840

cacacccttc tagcacctcc tgacagcagt gagaagatct gcaccgtcca gttggtgggt      900

aacagctgga cccctggcta ccccgagacc caggaggcgc tctgcccgca ggtgacatgg      960

tcctgggacc agttgcccag cagagctctt ggccccgctg ctgcgcccac actctcgcca     1020

gagtccccag ccggctcgcc agccatgatg ctgcagccgg gcccgcagct ctacgacgtg     1080

atggacgcgg tcccagcgcg gcgctggaag gagttcgtgc gcacgctggg gctgcgcgag     1140

gcagagatcg aagccgtgga ggtggagatc ggccgcttcc gagaccagca gtacgagatg     1200

ctcaagcgct ggcgccagca gcagcccgcg ggcctcggag ccgtttacgc ggccctggag     1260

cgcatggggc tggacggctg cgtggaagac ttgcgcagcc gcctgcagcg cggcccgtga     1320

cacggcgccc acttgccacc taggcgctct ggtggccctt gcagaagccc taagtacggt     1380

tacttatgcg tgtagacatt ttatgtcact tattaagccg ctggcacggc cctgcgtagc     1440

agcaccagcc ggccccaccc ctgctcgccc ctatcgctcc agccaaggcg aagaagcacg     1500

aacgaatgtc gagagggggt gaagacattt ctcaacttct cggccggagt ttggctgaga     1560

tcgcggtatt aaatctgtga aagaaaacaa aacaaaacaa aaacggcttc ttggcgtttc     1620

tgcggggctg gggtgttaag tggactggac ttttctcgag ggattcgaag gggacgggaa     1680

tcttgtcacc ccgggatctg gcacccatgg tggagtccag tgtggcctta gctcccaagc     1740

ctgcccctcc cgagtccact ctggctcaat taccccgaga aggagagagc aagtcgcggc     1800

cacagcgagt gagtgaaccg gagcccagat gagagcgctt taatggggct gcgaggtggc     1860

ggagacaggg tcgggatggg gtgcagcagt tggagacaca gggtcagggc ccctcatcct     1920

ctattcactc caccggggca gtgaaagggt cccggcagcg agtgggtc                  1968


<210> 176
<211> 417
<212> PRT
<213> Homo sapiens

<400> 176
Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr Ser Thr Leu Gly Ser Cys Pro Glu Arg Cys Ala 
            180                 185                 190         


Ala Val Cys Gly Trp Arg Gln Met Phe Trp Val Gln Val Leu Leu Ala 
        195                 200                 205             


Gly Leu Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr 
    210                 215                 220                 


Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly 
225                 230                 235                 240 


Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp 
                245                 250                 255     


Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys 
            260                 265                 270         


Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr 
        275                 280                 285             


Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro 
    290                 295                 300                 


Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser 
305                 310                 315                 320 


Pro Ala Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr 
                325                 330                 335     


Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg 
            340                 345                 350         


Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile 
        355                 360                 365             


Gly Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln 
    370                 375                 380                 


Gln Gln Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met 
385                 390                 395                 400 


Gly Leu Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly 
                405                 410                 415     


Pro 
    


<210> 177
<211> 1611
<212> DNA
<213> Mus musculus

<400> 177
ctgcgtggag gggaaatggg ccagaggctg ctggcagggg gcctcctctg ctgtacacaa       60

gctggttttg tagacagtga gagggaagct gatcccagtc ccctaaccct gttctgccca      120

ggagcctgag aactgagctt actcgggcaa atgctagggc ttcagaaatg gaggagctgc      180

ctaggaggga gaggtcacct cctggggcag ccacaccagg gtcaactgca cgtgttctcc      240

agcctctgtt cctaccactg ctgctgctgc tgctgctgct gcttggtggc cagggccagg      300

gcggcatgtc tggcaggtgt gactgtgcca gtgagtccca gaagaggtat ggcccgtttt      360

gttgcagggg ctgcccaaag ggacactaca tgaaggcccc ctgcgcagaa ccctgtggca      420

actccacctg ccttccctgt ccctcggaca ccttcttgac cagagacaac cactttaaga      480

ctgactgtac ccgctgccaa gtctgtgatg aagaggccct tcaagtgacc cttgagaact      540

gctcggcaaa gtcggacacc cactgtggct gccagtcagg ctggtgtgtt gactgctcca      600

ccgagccatg tgggaaaagc tcacctttct cttgtgtccc atgcggggct acaacaccag      660

tccatgaggc tccaaccccc ctgttttggg tccaggtgct tctaggagtc gcgttccttt      720

ttggggctat cctgatctgt gcatattgtc gatggcagcc ttgtaaggcc gtggtcactg      780

cagacacagc tgggacggag accctggcct caccacagac tgcccatctc tcagcctcag      840

acagcgccca caccctcctg gcacctccaa gcagtactgg gaaaatctgt accactgtcc      900

agttggtagg caacaactgg acccctggct tatcccagac tcaggaggtg gtctgcggac      960

aggcctcaca accctgggat cagctgccaa acagaactct tggaactcct ctggcatctc     1020

cgctctcgcc agcgccccct gcgggctctc cggctgctgt gctccagcct ggcccgcagc     1080

tctacgatgt gatggatgcg gtcccagcac gaaggtggaa ggagttcgtg cgcacgctgg     1140

ggctgcggga agcggaaatt gaagccgtgg aggtggaaat ctgccgcttc cgagaccagc     1200

agtatgagat gctcaagcgc tggcgtcagc agcagcctgc aggcctcggt gccatctatg     1260

cggctctgga gcgcatgggt ctggaaggct gtgccgagga cctgcgcagc cgcctgcagc     1320

gtggcccgtg atggaaggtc catcagccac tttgacaccc tagtgaccct tgaaggagcc     1380

ttaagtattg ttacttatgc gtgtagacat tttatgtcaa ttactaaccc cctgccgtgg     1440

tcctgcgtag cagggctggc tgcctcactt ttgcttatct gcagcacgga gctcctgcta     1500

agggaagcgt catggagaaa taccagaagg ggccaagtga ttggttgctc agctgttaat     1560

tagcccgagt ttggacttgg tattaaattt cgtaagaaaa gcagctgctt g              1611


<210> 178
<211> 387
<212> PRT
<213> Mus musculus

<400> 178
Met Glu Glu Leu Pro Arg Arg Glu Arg Ser Pro Pro Gly Ala Ala Thr 
1               5                   10                  15      


Pro Gly Ser Thr Ala Arg Val Leu Gln Pro Leu Phe Leu Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Gly Gly Gln Gly Gln Gly Gly Met Ser 
        35                  40                  45              


Gly Arg Cys Asp Cys Ala Ser Glu Ser Gln Lys Arg Tyr Gly Pro Phe 
    50                  55                  60                  


Cys Cys Arg Gly Cys Pro Lys Gly His Tyr Met Lys Ala Pro Cys Ala 
65                  70                  75                  80  


Glu Pro Cys Gly Asn Ser Thr Cys Leu Pro Cys Pro Ser Asp Thr Phe 
                85                  90                  95      


Leu Thr Arg Asp Asn His Phe Lys Thr Asp Cys Thr Arg Cys Gln Val 
            100                 105                 110         


Cys Asp Glu Glu Ala Leu Gln Val Thr Leu Glu Asn Cys Ser Ala Lys 
        115                 120                 125             


Ser Asp Thr His Cys Gly Cys Gln Ser Gly Trp Cys Val Asp Cys Ser 
    130                 135                 140                 


Thr Glu Pro Cys Gly Lys Ser Ser Pro Phe Ser Cys Val Pro Cys Gly 
145                 150                 155                 160 


Ala Thr Thr Pro Val His Glu Ala Pro Thr Pro Leu Phe Trp Val Gln 
                165                 170                 175     


Val Leu Leu Gly Val Ala Phe Leu Phe Gly Ala Ile Leu Ile Cys Ala 
            180                 185                 190         


Tyr Cys Arg Trp Gln Pro Cys Lys Ala Val Val Thr Ala Asp Thr Ala 
        195                 200                 205             


Gly Thr Glu Thr Leu Ala Ser Pro Gln Thr Ala His Leu Ser Ala Ser 
    210                 215                 220                 


Asp Ser Ala His Thr Leu Leu Ala Pro Pro Ser Ser Thr Gly Lys Ile 
225                 230                 235                 240 


Cys Thr Thr Val Gln Leu Val Gly Asn Asn Trp Thr Pro Gly Leu Ser 
                245                 250                 255     


Gln Thr Gln Glu Val Val Cys Gly Gln Ala Ser Gln Pro Trp Asp Gln 
            260                 265                 270         


Leu Pro Asn Arg Thr Leu Gly Thr Pro Leu Ala Ser Pro Leu Ser Pro 
        275                 280                 285             


Ala Pro Pro Ala Gly Ser Pro Ala Ala Val Leu Gln Pro Gly Pro Gln 
    290                 295                 300                 


Leu Tyr Asp Val Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe 
305                 310                 315                 320 


Val Arg Thr Leu Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val 
                325                 330                 335     


Glu Ile Cys Arg Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp 
            340                 345                 350         


Arg Gln Gln Gln Pro Ala Gly Leu Gly Ala Ile Tyr Ala Ala Leu Glu 
        355                 360                 365             


Arg Met Gly Leu Glu Gly Cys Ala Glu Asp Leu Arg Ser Arg Leu Gln 
    370                 375                 380                 


Arg Gly Pro 
385         


<210> 179
<211> 1140
<212> DNA
<213> Homo sapiens

<400> 179
ggacttgggc ggcccctccg caggcggacc gggggcaaag gaggtggcat gtcggtcagg       60

cacagcaggg tcctgtgtcc gcgctgagcc gcgctctccc tgctccagca aggaccatga      120

gggcgctgga ggggccaggc ctgtcgctgc tgtgcctggt gttggcgctg cctgccctgc      180

tgccggtgcc ggctgtacgc ggagtggcag aaacacccac ctacccctgg cgggacgcag      240

agacagggga gcggctggtg tgcgcccagt gccccccagg cacctttgtg cagcggccgt      300

gccgccgaga cagccccacg acgtgtggcc cgtgtccacc gcgccactac acgcagttct      360

ggaactacct agagcgctgc cgctactgca acgtcctctg cggggagcgt gaggaggagg      420

cacgggcttg ccacgccacc cacaaccgtg cctgccgctg ccgcaccggc ttcttcgcgc      480

acgctggttt ctgcttggag cacgcatcgt gtccacctgg tgccggcgtg attgccccgg      540

gcacccccag ccagaacacg cagtgccagc cgtgcccccc aggcaccttc tcagccagca      600

gctccagctc agagcagtgc cagccccacc gcaactgcac ggccctgggc ctggccctca      660

atgtgccagg ctcttcctcc catgacaccc tgtgcaccag ctgcactggc ttccccctca      720

gcaccagggt accaggagct gaggagtgtg agcgtgccgt catcgacttt gtggctttcc      780

aggacatctc catcaagagg ctgcagcggc tgctgcaggc cctcgaggcc ccggagggct      840

ggggtccgac accaagggcg ggccgcgcgg ccttgcagct gaagctgcgt cggcggctca      900

cggagctcct gggggcgcag gacggggcgc tgctggtgcg gctgctgcag gcgctgcgcg      960

tggccaggat gcccgggctg gagcggagcg tccgtgagcg cttcctccct gtgcactgat     1020

cctggccccc tcttatttat tctacatcct tggcacccca cttgcactga aagaggcttt     1080

tttttaaata gaagaaatga ggtttcttaa agcttatttt tataaagctt tttcataaaa     1140


<210> 180
<211> 300
<212> PRT
<213> Homo sapiens

<400> 180
Met Arg Ala Leu Glu Gly Pro Gly Leu Ser Leu Leu Cys Leu Val Leu 
1               5                   10                  15      


Ala Leu Pro Ala Leu Leu Pro Val Pro Ala Val Arg Gly Val Ala Glu 
            20                  25                  30          


Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu Arg Leu Val 
        35                  40                  45              


Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro Cys Arg Arg 
    50                  55                  60                  


Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His Tyr Thr Gln 
65                  70                  75                  80  


Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu Cys Gly 
                85                  90                  95      


Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn Arg Ala 
            100                 105                 110         


Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys Leu Glu 
        115                 120                 125             


His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly Thr Pro 
    130                 135                 140                 


Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys Thr Ala 
                165                 170                 175     


Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp Thr Leu 
            180                 185                 190         


Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro Gly Ala 
        195                 200                 205             


Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln Asp Ile 
    210                 215                 220                 


Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala Pro Glu 
225                 230                 235                 240 


Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly Ala Leu 
            260                 265                 270         


Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu 
        275                 280                 285             


Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
    290                 295                 300 


<210> 181
<211> 1805
<212> DNA
<213> Homo sapiens

<400> 181
agcagtcagc aacagggtcc cgtccttgac acctcagcct ctacaggact gagaagaagt       60

aaaaccgttt gctggggctg gcctgactca ccagctgcca tgcagcagcc cttcaattac      120

ccatatcccc agatctactg ggtggacagc agtgccagct ctccctgggc ccctccaggc      180

acagttcttc cctgtccaac ctctgtgccc agaaggcctg gtcaaaggag gccaccacca      240

ccaccgccac cgccaccact accacctccg ccgccgccgc caccactgcc tccactaccg      300

ctgccacccc tgaagaagag agggaaccac agcacaggcc tgtgtctcct tgtgatgttt      360

ttcatggttc tggttgcctt ggtaggattg ggcctgggga tgtttcagct cttccaccta      420

cagaaggagc tggcagaact ccgagagtct accagccaga tgcacacagc atcatctttg      480

gagaagcaaa taggccaccc cagtccaccc cctgaaaaaa aggagctgag gaaagtggcc      540

catttaacag gcaagtccaa ctcaaggtcc atgcctctgg aatgggaaga cacctatgga      600

attgtcctgc tttctggagt gaagtataag aagggtggcc ttgtgatcaa tgaaactggg      660

ctgtactttg tatattccaa agtatacttc cggggtcaat cttgcaacaa cctgcccctg      720

agccacaagg tctacatgag gaactctaag tatccccagg atctggtgat gatggagggg      780

aagatgatga gctactgcac tactgggcag atgtgggccc gcagcagcta cctgggggca      840

gtgttcaatc ttaccagtgc tgatcattta tatgtcaacg tatctgagct ctctctggtc      900

aattttgagg aatctcagac gtttttcggc ttatataagc tctaagagaa gcactttggg      960

attctttcca ttatgattct ttgttacagg caccgagaat gttgtattca gtgagggtct     1020

tcttacatgc atttgaggtc aagtaagaag acatgaacca agtggacctt gagaccacag     1080

ggttcaaaat gtctgtagct cctcaactca cctaatgttt atgagccaga caaatggagg     1140

aatatgacgg aagaacatag aactctgggc tgccatgtga agagggagaa gcatgaaaaa     1200

gcagctacca ggtgttctac actcatctta gtgcctgaga gtatttaggc agattgaaaa     1260

ggacaccttt taactcacct ctcaaggtgg gccttgctac ctcaaggggg actgtctttc     1320

agatacatgg ttgtgacctg aggatttaag ggatggaaaa ggaagactag aggcttgcat     1380

aataagctaa agaggctgaa agaggccaat gccccactgg cagcatcttc acttctaaat     1440

gcatatcctg agccatcggt gaaactaaca gataagcaag agagatgttt tggggactca     1500

tttcattcct aacacagcat gtgtatttcc agtgcaattg taggggtgtg tgtgtgtgtg     1560

tgtgtgtgtg tgtgtgtatg actaaagaga gaatgtagat attgtgaagt acatattagg     1620

aaaatatggg ttgcatttgg tcaagatttt gaatgcttcc tgacaatcaa ctctaatagt     1680

gcttaaaaat cattgattgt cagctactaa tgatgttttc ctataatata ataaatattt     1740

atgtagatgt gcatttttgt gaaatgaaaa catgtaataa aaagtatatg ttaggataca     1800

aataa                                                                 1805


<210> 182
<211> 281
<212> PRT
<213> Homo sapiens

<400> 182
Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210> 183
<211> 1935
<212> DNA
<213> Mus musculus

<400> 183
tgaggcttct cagcttcaga tgcaagtgag tgggtgtctc acagagaagc aaagagaaga       60

gaacaggaga aaggtgtttc ccttgactgc ggaaacttta taaagaaaac ttagcttctc      120

tggagcagtc agcgtcagag ttctgtcctt gacacctgag tctcctccac aaggctgtga      180

gaaggaaacc ctttcctggg gctgggtgcc atgcagcagc ccatgaatta cccatgtccc      240

cagatcttct gggtagacag cagtgccact tcatcttggg ctcctccagg gtcagttttt      300

ccctgtccat cttgtgggcc tagagggccg gaccaaagga gaccgccacc tccaccacca      360

cctgtgtcac cactaccacc gccatcacaa ccactcccac tgccgccact gacccctcta      420

aagaagaagg accacaacac aaatctgtgg ctaccggtgg tatttttcat ggttctggtg      480

gctctggttg gaatgggatt aggaatgtat cagctcttcc acctgcagaa ggaactggca      540

gaactccgtg agttcaccaa ccaaagcctt aaagtatcat cttttgaaaa gcaaatagcc      600

aaccccagta caccctctga aaaaaaagag ccgaggagtg tggcccattt aacagggaac      660

ccccactcaa ggtccatccc tctggaatgg gaagacacat atggaaccgc tctgatctct      720

ggagtgaagt ataagaaagg tggccttgtg atcaacgaaa ctgggttgta cttcgtgtat      780

tccaaagtat acttccgggg tcagtcttgc aacaaccagc ccctaaacca caaggtctat      840

atgaggaact ctaagtatcc tgaggatctg gtgctaatgg aggagaagag gttgaactac      900

tgcactactg gacagatatg ggcccacagc agctacctgg gggcagtatt caatcttacc      960

agtgctgacc atttatatgt caacatatct caactctctc tgatcaattt tgaggaatct     1020

aagacctttt tcggcttgta taagctttaa aagaaaaagc attttaaaat gatctactat     1080

tctttatcat gggcaccagg aatattgtct tgaatgagag tcttcttaag acctattgag     1140

attaattaag actacatgag ccacaaagac ctcatgaccg caaggtccaa caggtcagct     1200

atccttcatt ttctcgaggt ccatggagtg gtccttaatg cctgcatcat gagccagatg     1260

gaaggaggtc tgtgactgag ggacataaag ctttgggctg ctgtgtgaca atgcagaggc     1320

acagagaaag aactgtctga tgttaaatgg ccaagagaat tttaaccatt gaagaagaca     1380

cctttacact cacttccagg gtgggtctac ttactacctc acagaggccg tttttgagac     1440

atagttgtgg tatgaatata caagggtgag aaaggaggct catttgactg ataagctaga     1500

gactgaaaaa aagacagtgt ctcattggca ccatctttac tgttacctaa tgttttctga     1560

gccgaccttt gatcctaacg gagaagtaag agggatgttt gaggcacaaa tcattctcta     1620

catagcatgc atacctccag tgcaatgatg tctgtgtgtt tgtatgtatg agagcaaaca     1680

gattctaagg agtcatataa ataaaatatg tacattatgg agtacatatt agaaacctgt     1740

tacatttgat gctagatatc tgaatgtttc ttggcaataa actctaatag tcttcaaaat     1800

cttttattat cagctactga tgctgttttt ctttaataca actagtattt atgctctgaa     1860

catcctaatg aggaaaagac aaataaaatt atgttataga atacagaaat gccttaagga     1920

catagacttt ggaaa                                                      1935


<210> 184
<211> 279
<212> PRT
<213> Mus musculus

<400> 184
Met Gln Gln Pro Met Asn Tyr Pro Cys Pro Gln Ile Phe Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Thr Ser Ser Trp Ala Pro Pro Gly Ser Val Phe Pro Cys 
            20                  25                  30          


Pro Ser Cys Gly Pro Arg Gly Pro Asp Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Val Ser Pro Leu Pro Pro Pro Ser Gln Pro Leu Pro Leu 
    50                  55                  60                  


Pro Pro Leu Thr Pro Leu Lys Lys Lys Asp His Asn Thr Asn Leu Trp 
65                  70                  75                  80  


Leu Pro Val Val Phe Phe Met Val Leu Val Ala Leu Val Gly Met Gly 
                85                  90                  95      


Leu Gly Met Tyr Gln Leu Phe His Leu Gln Lys Glu Leu Ala Glu Leu 
            100                 105                 110         


Arg Glu Phe Thr Asn Gln Ser Leu Lys Val Ser Ser Phe Glu Lys Gln 
        115                 120                 125             


Ile Ala Asn Pro Ser Thr Pro Ser Glu Lys Lys Glu Pro Arg Ser Val 
    130                 135                 140                 


Ala His Leu Thr Gly Asn Pro His Ser Arg Ser Ile Pro Leu Glu Trp 
145                 150                 155                 160 


Glu Asp Thr Tyr Gly Thr Ala Leu Ile Ser Gly Val Lys Tyr Lys Lys 
                165                 170                 175     


Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys 
            180                 185                 190         


Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Gln Pro Leu Asn His Lys 
        195                 200                 205             


Val Tyr Met Arg Asn Ser Lys Tyr Pro Glu Asp Leu Val Leu Met Glu 
    210                 215                 220                 


Glu Lys Arg Leu Asn Tyr Cys Thr Thr Gly Gln Ile Trp Ala His Ser 
225                 230                 235                 240 


Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr 
                245                 250                 255     


Val Asn Ile Ser Gln Leu Ser Leu Ile Asn Phe Glu Glu Ser Lys Thr 
            260                 265                 270         


Phe Phe Gly Leu Tyr Lys Leu 
        275                 


<210> 185
<211> 1713
<212> DNA
<213> Homo sapiens

<400> 185
gaccaggagt cagtttggcg gttatgtgtg gggaagaagc tgggaagtca ggggctgttt       60

ctgtggacag ctttccctgt cctttggaag gcacagagct ctcagctgca gggaactaac      120

agagctctga agccgttata tgtggtcttc tctcatttcc agcagagcag gctcatatga      180

atcaaccaac tgggtgaaaa gataagttgc aatctgagat ttaagacttg atcagatacc      240

atctggtgga gggtaccaac cagcctgtct gctcattttc cttcaggctg atcccataat      300

gcatcctcaa gtggtcatct taagcctcat cctacatctg gcagattctg tagctggttc      360

tgtaaaggtt ggtggagagg caggtccatc tgtcacacta ccctgccact acagtggagc      420

tgtcacatcc atgtgctgga atagaggctc atgttctcta ttcacatgcc aaaatggcat      480

tgtctggacc aatggaaccc acgtcaccta tcggaaggac acacgctata agctattggg      540

ggacctttca agaagggatg tctctttgac catagaaaat acagctgtgt ctgacagtgg      600

cgtatattgt tgccgtgttg agcaccgtgg gtggttcaat gacatgaaaa tcaccgtatc      660

attggagatt gtgccaccca aggtcacgac tactccaatt gtcacaactg ttccaaccgt      720

cacgactgtt cgaacgagca ccactgttcc aacgacaacg actgttccaa tgacgactgt      780

tccaacgaca actgttccaa caacaatgag cattccaacg acaacgactg ttctgacgac      840

aatgactgtt tcaacgacaa cgagcgttcc aacgacaacg agcattccaa caacaacaag      900

tgttccagtg acaacaactg tctctacctt tgttcctcca atgcctttgc ccaggcagaa      960

ccatgaacca gtagccactt caccatcttc acctcagcca gcagaaaccc accctacgac     1020

actgcaggga gcaataagga gagaacccac cagctcacca ttgtactctt acacaacaga     1080

tgggaatgac accgtgacag agtcttcaga tggcctttgg aataacaatc aaactcaact     1140

gttcctagaa catagtctac tgacggccaa taccactaaa ggaatctatg ctggagtctg     1200

tatttctgtc ttggtgcttc ttgctctttt gggtgtcatc attgccaaaa agtatttctt     1260

caaaaaggag gttcaacaac taagtgtttc atttagcagc cttcaaatta aagctttgca     1320

aaatgcagtt gaaaaggaag tccaagcaga agacaatatc tacattgaga atagtcttta     1380

tgccacggac taagacccag tggtgctctt tgagagttta cgcccatgag tgcagaagac     1440

tgaacagaca tcagcacatc agacgtcttt tagaccccaa gacaattttt ctgtttcagt     1500

ttcatctggc attccaacat gtcagtgata ctgggtagag taactctctc actccaaact     1560

gtgtatagtc aacctcatca ttaatgtagt cctaattttt tatgctaaaa ctggctcaat     1620

ccttctgatc attgcagttt tctctcaaat atgaacactt tataattgta tgttcttttt     1680

agaccccata aatcctgtat acatcaaaga gaa                                  1713


<210> 186
<211> 364
<212> PRT
<213> Homo sapiens

<400> 186
Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210> 187
<211> 1909
<212> DNA
<213> Mus musculus

<400> 187
gtcagtacca tgaatcagat tcaagtcttc atttcaggcc tcatactgct tctcccaggc       60

gctgtggatt cttatgtgga agtaaagggg gtggtgggtc accctgtcac acttccatgt      120

acttactcaa catatcgtgg aatcacaacg acatgttggg gccgagggca atgcccatct      180

tctgcttgtc aaaatacact tatttggacc aatggacatc gtgtcaccta tcagaagagc      240

agtcggtaca acttaaaggg gcatatttca gaaggagatg tgtccttgac gatagagaac      300

tctgttgaga gtgacagtgg tctgtattgt tgtcgagtgg agattcctgg atggtttaat      360

gatcagaaag tgaccttttc attgcaagtt aaaccagaga ttcccacacg tcctccaaga      420

agacccacaa ctacaaggcc cacagctaca ggaagaccca cgactatttc aacaagatcc      480

acacatgtac caacatcaac cagagtctct acctccactc ctccaacatc tacacacaca      540

tggactcaca aaccagaacc cactacattt tgtccccatg agacaacagc tgaggtgaca      600

ggaatcccat cccatactcc tacagactgg aatggcactg tgacatcctc aggagatacc      660

tggagtaatc acactgaagc aatccctcca gggaagccgc agaaaaaccc tactaagggc      720

ttctatgttg gcatctgcat cgcagccctg ctgctactgc tccttgtgag caccgtggct      780

atcaccaggt acatacttat gaaaaggaag tcagcatctc taagcgtggt tgccttccgt      840

gtctctaaga ttgaagcttt gcagaacgca gcggttgtgc attcccgagc tgaagacaac      900

atctacattg ttgaagatag accttgaggg gcagaatgag taccagtggc cctctgaggg      960

accttctgcc tgagatttat agagactgtc actgatgtca tagagtcaca cccattacag     1020

cgccaaggcg attttctgtg ttggttcttc cagctgcagc agagagggta accctctact     1080

gtgtatactc aaaactcaga ttaacatcat cctaattttg gtatctgcac cacctccgtg     1140

tctctgctca ctacagagat tctctcaaac atgaacgttt tagaagtttg tgtttccctt     1200

agtcaatgta atcattggta atactattct attcttggtt actaaaacca ttactaagag     1260

agggatagga attaaaagtt ggtgtgaggg gcctcctgaa tttagaagca cttgattctg     1320

ttttatctac tttcttgaaa tgttacttct acccttccca atgggtaaaa tcatgggagc     1380

atggtgccct catagataaa tagaagagag tctattgctg ccaatataga tggttatgct     1440

ttctcatagc tctgaaaata tgacacattt attatgaggt tgatcttagg ataaggatag     1500

gtgttttatg tcaggagagg ttatcatggt gaatatggac cagcagacag cagtggagga     1560

aaataatgaa ccaagggatt gagttcatta gtgctaattc tactccactc ctgtctttat     1620

gctcctaaac ttactgactg agctctgaat taggtgctag gaggagacaa tgcagacatg     1680

aaaggggaag gagcgccttc aggacacagg ctctctgctg agagaagtcc tatttgcagg     1740

tgtgatagag gttgggacaa tctctgagtt gtaaatttct aattgtcttc aggccatatt     1800

tatagttaaa ttcatttccg aaagacatag catcttcccc aatgggtcag tttgtcaaaa     1860

tcaataaaat attttgtttt gctaagaatt aaaaaaaaaa aaaaaaaaa                 1909


<210> 188
<211> 305
<212> PRT
<213> Mus musculus

<400> 188
Met Asn Gln Ile Gln Val Phe Ile Ser Gly Leu Ile Leu Leu Leu Pro 
1               5                   10                  15      


Gly Ala Val Asp Ser Tyr Val Glu Val Lys Gly Val Val Gly His Pro 
            20                  25                  30          


Val Thr Leu Pro Cys Thr Tyr Ser Thr Tyr Arg Gly Ile Thr Thr Thr 
        35                  40                  45              


Cys Trp Gly Arg Gly Gln Cys Pro Ser Ser Ala Cys Gln Asn Thr Leu 
    50                  55                  60                  


Ile Trp Thr Asn Gly His Arg Val Thr Tyr Gln Lys Ser Ser Arg Tyr 
65                  70                  75                  80  


Asn Leu Lys Gly His Ile Ser Glu Gly Asp Val Ser Leu Thr Ile Glu 
                85                  90                  95      


Asn Ser Val Glu Ser Asp Ser Gly Leu Tyr Cys Cys Arg Val Glu Ile 
            100                 105                 110         


Pro Gly Trp Phe Asn Asp Gln Lys Val Thr Phe Ser Leu Gln Val Lys 
        115                 120                 125             


Pro Glu Ile Pro Thr Arg Pro Pro Arg Arg Pro Thr Thr Thr Arg Pro 
    130                 135                 140                 


Thr Ala Thr Gly Arg Pro Thr Thr Ile Ser Thr Arg Ser Thr His Val 
145                 150                 155                 160 


Pro Thr Ser Thr Arg Val Ser Thr Ser Thr Pro Pro Thr Ser Thr His 
                165                 170                 175     


Thr Trp Thr His Lys Pro Glu Pro Thr Thr Phe Cys Pro His Glu Thr 
            180                 185                 190         


Thr Ala Glu Val Thr Gly Ile Pro Ser His Thr Pro Thr Asp Trp Asn 
        195                 200                 205             


Gly Thr Val Thr Ser Ser Gly Asp Thr Trp Ser Asn His Thr Glu Ala 
    210                 215                 220                 


Ile Pro Pro Gly Lys Pro Gln Lys Asn Pro Thr Lys Gly Phe Tyr Val 
225                 230                 235                 240 


Gly Ile Cys Ile Ala Ala Leu Leu Leu Leu Leu Leu Val Ser Thr Val 
                245                 250                 255     


Ala Ile Thr Arg Tyr Ile Leu Met Lys Arg Lys Ser Ala Ser Leu Ser 
            260                 265                 270         


Val Val Ala Phe Arg Val Ser Lys Ile Glu Ala Leu Gln Asn Ala Ala 
        275                 280                 285             


Val Val His Ser Arg Ala Glu Asp Asn Ile Tyr Ile Val Glu Asp Arg 
    290                 295                 300                 


Pro 
305 


<210> 189
<211> 2097
<212> DNA
<213> Homo sapiens

<400> 189
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc      180

tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga      240

gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgcct      300

tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca      360

acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc      420

tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg cgggcagagc      480

tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc tcacccaggc      540

cagccggcca gttccaaacc ctggtggttg gtgtcgtggg cggcctgctg ggcagcctgg      600

tgctgctagt ctgggtcctg gccgtcatct gctcccgggc cgcacgaggg acaataggag      660

ccaggcgcac cggccagccc ctgaaggagg acccctcagc cgtgcctgtg ttctctgtgg      720

actatgggga gctggatttc cagtggcgag agaagacccc ggagcccccc gtgccctgtg      780

tccctgagca gacggagtat gccaccattg tctttcctag cggaatgggc acctcatccc      840

ccgcccgcag gggctcagct gacggccctc ggagtgccca gccactgagg cctgaggatg      900

gacactgctc ttggcccctc tgaccggctt ccttggccac cagtgttctg cagaccctcc      960

accatgagcc cgggtcagcg catttcctca ggagaagcag gcagggtgca ggccattgca     1020

ggccgtccag gggctgagct gcctgggggc gaccggggct ccagcctgca cctgcaccag     1080

gcacagcccc accacaggac tcatgtctca atgcccacag tgagcccagg cagcaggtgt     1140

caccgtcccc tacagggagg gccagatgca gtcactgctt caggtcctgc cagcacagag     1200

ctgcctgcgt ccagctccct gaatctctgc tgctgctgct gctgctgctg ctgctgcctg     1260

cggcccgggg ctgaaggcgc cgtggccctg cctgacgccc cggagcctcc tgcctgaact     1320

tgggggctgg ttggagatgg ccttggagca gccaaggtgc ccctggcagt ggcatcccga     1380

aacgccctgg acgcagggcc caagactggg cacaggagtg ggaggtacat ggggctgggg     1440

actccccagg agttatctgc tccctgcagg cctagagaag tttcagggaa ggtcagaaga     1500

gctcctggct gtggtgggca gggcaggaaa cccctccacc tttacacatg cccaggcagc     1560

acctcaggcc ctttgtgggg cagggaagct gaggcagtaa gcgggcaggc agagctggag     1620

gcctttcagg cccagccagc actctggcct cctgccgccg cattccaccc cagcccctca     1680

caccactcgg gagagggaca tcctacggtc ccaaggtcag gagggcaggg ctggggttga     1740

ctcaggcccc tcccagctgt ggccacctgg gtgttgggag ggcagaagtg caggcaccta     1800

gggcccccca tgtgcccacc ctgggagctc tccttggaac ccattcctga aattatttaa     1860

aggggttggc cgggctccca ccagggcctg ggtgggaagg tacaggcgtt cccccggggc     1920

ctagtacccc cgccgtggcc tatccactcc tcacatccac acactgcacc cccactcctg     1980

gggcagggcc accagcatcc aggcggccag caggcacctg agtggctggg acaagggatc     2040

ccccttccct gtggttctat tatattataa ttataattaa atatgagagc atgctaa        2097


<210> 190
<211> 288
<212> PRT
<213> Homo sapiens

<400> 190
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 191
<211> 1933
<212> DNA
<213> Mus musculus

<400> 191
tgagcagcgg ggaggaggaa gaggagactg ctactgaagg cgacactgcc aggggctctg       60

ggcatgtggg tccggcaggt accctggtca ttcacttggg ctgtgctgca gttgagctgg      120

caatcagggt ggcttctaga ggtccccaat gggccctgga ggtccctcac cttctaccca      180

gcctggctca cagtgtcaga gggagcaaat gccaccttca cctgcagctt gtccaactgg      240

tcggaggatc ttatgctgaa ctggaaccgc ctgagtccca gcaaccagac tgaaaaacag      300

gccgccttct gtaatggttt gagccaaccc gtccaggatg cccgcttcca gatcatacag      360

ctgcccaaca ggcatgactt ccacatgaac atccttgaca cacggcgcaa tgacagtggc      420

atctacctct gtggggccat ctccctgcac cccaaggcaa aaatcgagga gagccctgga      480

gcagagctcg tggtaacaga gagaatcctg gagacctcaa caagatatcc cagcccctcg      540

cccaaaccag aaggccggtt tcaaggcatg gtcattggta tcatgagtgc cctagtgggt      600

atccctgtat tgctgctgct ggcctgggcc ctagctgtct tctgctcaac aagtatgtca      660

gaggccagag gagctggaag caaggacgac actctgaagg aggagccttc agcagcacct      720

gtccctagtg tggcctatga ggagctggac ttccagggac gagagaagac accagagctc      780

cctaccgcct gtgtgcacac agaatatgcc accattgtct tcactgaagg gctgggtgcc      840

tcggccatgg gacgtagggg ctcagctgat ggcctgcagg gtcctcggcc tccaagacat      900

gaggatggac attgttcttg gcctctttga ccagattctt cagccattag catgctgcag      960

accctccaca gagagcaccg gtccgtccct cagtcaagag gagcatgcag gctacagttc     1020

agccaaggct cccagggtct gagctagctg gagtgacagc ccagcgcctg caccaattcc     1080

agcacatgca ctgttgagtg agagctcact tcaggtttac cacaagctgg gagcagcagg     1140

cttcccggtt tcctattgtc acaaggtgca gagctggggc ctaagcctat gtctcctgaa     1200

tcctactgtt gggcacttct agggacttga gacactatag ccaatggcct ctgtgggttc     1260

tgtgcctgga aatggagaga tctgagtaca gcctgctttg aatggccctg tgaggcaacc     1320

ccaaagcaag ggggtccagg tatactatgg gcccagcacc taaagccacc cttgggagat     1380

gatactcagg tgggaaattc gtagactggg ggactgaacc aatcccaaga tctggaaaag     1440

ttttgatgaa gacttgaaaa gctcctagct tcgggggtct gggaagcatg agcacttacc     1500

aggcaaaagc tccgtgagcg tatctgctgt ccttctgcat gcccaggtac ctcagttttt     1560

ttcaacagca aggaaactag ggcaataaag ggaaccagca gagctagagc cacccacaca     1620

tccagggggg cacttgactc tccctactcc tcctaggaac caaaaggaca aagtccatgt     1680

tgacagcagg gaaggaaagg gggatataac cttgacgcaa accaacactg gggtgttaga     1740

atctcctcat tcactctgtc ctggagttgg gttctggctc tccttcacac ctaggactct     1800

gaaatgagca agcacttcag acagtcaggg tagcaagagt ctagctgtct ggtgggcacc     1860

caaaatgacc agggcttaag tccctttcct ttggtttaag cccgttataa ttaaatggta     1920

ccaaaagctt taa                                                        1933


<210> 192
<211> 696
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 192
atggtgagca agggcgaggc agtgatcaag gagttcatgc ggttcaaggt gcacatggag       60

ggctccatga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag      120

ggcacccaga ccgccaagct gaaggtgacc aagggtggcc ccctgccctt ctcctgggac      180

atcctgtccc ctcagttcat gtacggctcc agggccttca ccaagcaccc cgccgacatc      240

cccgactact ataagcagtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc      300

gaggacggcg gcgccgtgac cgtgacccag gacacctccc tggaggacgg caccctgatc      360

tacaaggtga agctccgcgg caccaacttc cctcctgacg gccccgtaat gcagaagaag      420

acaatgggct gggaagcgtc caccgagcgg ttgtaccccg aggacggcgt gctgaagggc      480

gacattaaga tggccctgcg cctgaaggac ggcggccgct acctggcgga cttcaagacc      540

acctacaagg ccaagaagcc cgtgcagatg cccggcgcct acaacgtcga ccgcaagttg      600

gacatcacct cccacaacga ggactacacc gtggtggaac agtacgaacg ctccgagggc      660

cgccactcca ccggcggcat ggacgagctg tacaag                                696


<210> 193
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 193
Met Val Ser Lys Gly Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys 
1               5                   10                  15      


Val His Met Glu Gly Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly 
            20                  25                  30          


Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys 
        35                  40                  45              


Val Thr Lys Gly Gly Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro 
    50                  55                  60                  


Gln Phe Met Tyr Gly Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile 
65                  70                  75                  80  


Pro Asp Tyr Tyr Lys Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg 
                85                  90                  95      


Val Met Asn Phe Glu Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr 
            100                 105                 110         


Ser Leu Glu Asp Gly Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr 
        115                 120                 125             


Asn Phe Pro Pro Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp 
    130                 135                 140                 


Glu Ala Ser Thr Glu Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly 
145                 150                 155                 160 


Asp Ile Lys Met Ala Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala 
                165                 170                 175     


Asp Phe Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly 
            180                 185                 190         


Ala Tyr Asn Val Asp Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp 
        195                 200                 205             


Tyr Thr Val Val Glu Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr 
    210                 215                 220                 


Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230         


<210> 194
<211> 3861
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 194
ggcctaactg gcctcaatat tggccattag ccatattatt cattggttat atagcataaa       60

tcaatattgg ctattggcca ttgcatacgt tgtatctata tcataatatg tacatttata      120

ttggctcatg tccaatatga ccgccatgtt ggcattgatt attgactagt tattaatagt      180

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      240

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      300

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      360

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt ccgcccccta      420

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttacggg      480

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt      540

tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      600

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      660

gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      720

atataagcag agctcgttta gtgaaccgtc agatcactag aagctttatt gcggtagttt      780

atcacagtta aattgctaac gcagtcagtg ggcctcggcg gccaagcttg gcaatccggt      840

actgttggta aagccaccat ggtcttcaca ctcgaagatt tcgttgggga ctggcgacag      900

acagccggct acaacctgga ccaagtcctt gaacagggag gtgtgtccag tttgtttcag      960

aatctcgggg tgtccgtaac tccgatccaa aggattgtcc tgagcggtga aaatgggctg     1020

aagatcgaca tccatgtcat catcccgtat gaaggtctga gcggcgacca aatgggccag     1080

atcgaaaaaa tttttaaggt ggtgtaccct gtggatgatc atcactttaa ggtgatcctg     1140

cactatggca cactggtaat cgacggggtt acgccgaaca tgatcgacta tttcggacgg     1200

ccgtatgaag gcatcgccgt gttcgacggc aaaaagatca ctgtaacagg gaccctgtgg     1260

aacggcaaca aaattatcga cgagcgcctg atcaaccccg acggctccct gctgttccga     1320

gtaaccatca acggagtgac cggctggcgg ctgtgcgaac gcattctggc gtaattctag     1380

agtcggggcg gccggccgct tcgagcagac atgataagat acattgatga gtttggacaa     1440

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     1500

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     1560

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa     1620

tgtggtaaaa tcgataagga tccgtcgacc gatgcccttg agagccttca acccagtcag     1680

ctccttccgg tgggcgcggg gcatgactat cgtcgccgca cttatgactg tcttctttat     1740

catgcaactc gtaggacagg tgccggcagc gctcttccgc ttcctcgctc actgactcgc     1800

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     1860

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     1920

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     1980

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     2040

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     2100

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     2160

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     2220

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     2280

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     2340

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag     2400

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     2460

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     2520

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     2580

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     2640

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     2700

cttggtctga cagcggccgc aaatgctaaa ccactgcagt ggttaccagt gcttgatcag     2760

tgaggcaccg atctcagcga tctgcctatt tcgttcgtcc atagtggcct gactccccgt     2820

cgtgtagatc actacgattc gtgagggctt accatcaggc cccagcgcag caatgatgcc     2880

gcgagagccg cgttcaccgg cccccgattt gtcagcaatg aaccagccag cagggagggc     2940

cgagcgaaga agtggtcctg ctactttgtc cgcctccatc cagtctatga gctgctgtcg     3000

tgatgctaga gtaagaagtt cgccagtgag tagtttccga agagttgtgg ccattgctac     3060

tggcatcgtg gtatcacgct cgtcgttcgg tatggcttcg ttcaactctg gttcccagcg     3120

gtcaagccgg gtcacatgat cacccatatt atgaagaaat gcagtcagct ccttagggcc     3180

tccgatcgtt gtcagaagta agttggccgc ggtgttgtcg ctcatggtaa tggcagcact     3240

acacaattct cttaccgtca tgccatccgt aagatgcttt tccgtgaccg gcgagtactc     3300

aaccaagtcg ttttgtgagt agtgtatacg gcgaccaagc tgctcttgcc cggcgtctat     3360

acgggacaac accgcgccac atagcagtac tttgaaagtg ctcatcatcg ggaatcgttc     3420

ttcggggcgg aaagactcaa ggatcttgcc gctattgaga tccagttcga tatagcccac     3480

tcttgcaccc agttgatctt cagcatcttt tactttcacc agcgtttcgg ggtgtgcaaa     3540

aacaggcaag caaaatgccg caaagaaggg aatgagtgcg acacgaaaat gttggatgct     3600

catactcgtc ctttttcaat attattgaag catttatcag ggttactagt acgtctctca     3660

aggataagta agtaatatta aggtacggga ggtattggac aggccgcaat aaaatatctt     3720

tattttcatt acatctgtgt gttggttttt tgtgtgaatc gatagtacta acatacgctc     3780

tccatcaaaa caaaacgaaa caaaacaaac tagcaaaata ggctgtcccc agtgcaagtg     3840

caggtgccag aacatttctc t                                               3861


<210> 195
<211> 171
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 195
Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala 
1               5                   10                  15      


Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu 
        35                  40                  45              


Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val 
145                 150                 155                 160 


Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170     


<210> 196
<211> 2590
<212> DNA
<213> Homo sapiens

<400> 196
ctgcttactg caactcgctc cggccgctgg gcgtagctgc gactcggcgg agtcccggcg       60

gcgcgtcctt gttctaaccc ggcgcgccat gaccgtcgcg cggccgagcg tgcccgcggc      120

gctgcccctc ctcggggagc tgccccggct gctgctgctg gtgctgttgt gcctgccggc      180

cgtgtggggt gactgtggcc ttcccccaga tgtacctaat gcccagccag ctttggaagg      240

ccgtacaagt tttcccgagg atactgtaat aacgtacaaa tgtgaagaaa gctttgtgaa      300

aattcctggc gagaaggact cagtgatctg ccttaagggc agtcaatggt cagatattga      360

agagttctgc aatcgtagct gcgaggtgcc aacaaggcta aattctgcat ccctcaaaca      420

gccttatatc actcagaatt attttccagt cggtactgtt gtggaatatg agtgccgtcc      480

aggttacaga agagaacctt ctctatcacc aaaactaact tgccttcaga atttaaaatg      540

gtccacagca gtcgaatttt gtaaaaagaa atcatgccct aatccgggag aaatacgaaa      600

tggtcagatt gatgtaccag gtggcatatt atttggtgca accatctcct tctcatgtaa      660

cacagggtac aaattatttg gctcgacttc tagtttttgt cttatttcag gcagctctgt      720

ccagtggagt gacccgttgc cagagtgcag agaaatttat tgtccagcac caccacaaat      780

tgacaatgga ataattcaag gggaacgtga ccattatgga tatagacagt ctgtaacgta      840

tgcatgtaat aaaggattca ccatgattgg agagcactct atttattgta ctgtgaataa      900

tgatgaagga gagtggagtg gcccaccacc tgaatgcaga ggaaaatctc taacttccaa      960

ggtcccacca acagttcaga aacctaccac agtaaatgtt ccaactacag aagtctcacc     1020

aacttctcag aaaaccacca caaaaaccac cacaccaaat gctcaagcaa cacggagtac     1080

acctgtttcc aggacaacca agcattttca tgaaacaacc ccaaataaag gaagtggaac     1140

cacttcaggt actacccgtc ttctatctgg gcacacgtgt ttcacgttga caggtttgct     1200

tgggacgcta gtaaccatgg gcttgctgac ttagccaaag aagagttaag aagaaaatac     1260

acacaagtat acagactgtt cctagtttct tagacttatc tgcatattgg ataaaataaa     1320

tgcaattgtg ctcttcattt aggatgcttt cattgtcttt aagatgtgtt aggaatgtca     1380

acagagcaag gagaaaaaag gcagtcctgg aatcacattc ttagcacacc tacacctctt     1440

gaaaatagaa caacttgcag aattgagagt gattcctttc ctaaaagtgt aagaaagcat     1500

agagatttgt tcgtatttag aatgggatca cgaggaaaag agaaggaaag tgattttttt     1560

ccacaagatc tgtaatgtta tttccactta taaaggaaat aaaaaatgaa aaacattatt     1620

tggatatcaa aagcaaataa aaacccaatt cagtctcttc taagcaaaat tgctaaagag     1680

agatgaacca cattataaag taatctttgg ctgtaaggca ttttcatctt tccttcgggt     1740

tggcaaaata ttttaaaggt aaaacatgct ggtgaaccag gggtgttgat ggtgataagg     1800

gaggaatata gaatgaaaga ctgaatcttc ctttgttgca caaatagagt ttggaaaaag     1860

cctgtgaaag gtgtcttctt tgacttaatg tctttaaaag tatccagaga tactacaata     1920

ttaacataag aaaagattat atattatttc tgaatcgaga tgtccatagt caaatttgta     1980

aatcttattc ttttgtaata tttatttata tttatttatg acagtgaaca ttctgatttt     2040

acatgtaaaa caagaaaagt tgaagaagat atgtgaagaa aaatgtattt ttcctaaata     2100

gaaataaatg atcccatttt ttggtatcat gtagtatgtg aaatttattc ttaaacgtga     2160

ctactttatt tctaaataag aaattcccta cctgcttcct acaagcagtt cagaatgcca     2220

tgccttggtt gtcctagtgt gaataatttt cagctacttt aaaattatat tgtactttct     2280

caagcatgtc atatcctttc ctattagagt atctatatta cttgttactg atttacctga     2340

aggcaatctg attaatttct aggtttttac catattcttg tcatcttgcc aattacattt     2400

taagtgttag actagactaa gatgtactag ttgtatagaa tataactaga tttattatgg     2460

caatgtttat tttgtcattt tgcttcatct gttttgttgt tgaagtactt taaatttcat     2520

acgttcatgg catttcactg taaagacttt aatgtgtatt tcttaaaata aaactttttt     2580

tcctccttaa                                                            2590


<210> 197
<211> 381
<212> PRT
<213> Homo sapiens

<400> 197
Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210> 198
<211> 128
<212> PRT
<213> Homo sapiens

<400> 198
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210> 199
<211> 1936
<212> DNA
<213> Homo sapiens

<400> 199
agaaccccgc ggggtctgag cagcccagcg tgcccattcc agcgcccgcg tccccgcagc       60

atgccgcgcc cccgcctgct ggccgcgctg tgcggcgcgc tgctctgcgc ccccagcctc      120

ctcgtcgccc tggatatctg ttccaaaaac ccctgccaca acggtggttt atgcgaggag      180

atttcccaag aagtgcgagg agatgtcttc ccctcgtaca cctgcacgtg ccttaagggc      240

tacgcgggca accactgtga gacgaaatgt gtcgagccac tgggcctgga gaatgggaac      300

attgccaact cacagatcgc cgcctcgtct gtgcgtgtga ccttcttggg tttgcagcat      360

tgggtcccgg agctggcccg cctgaaccgc gcaggcatgg tcaatgcctg gacacccagc      420

agcaatgacg ataacccctg gatccaggtg aacctgctgc ggaggatgtg ggtaacaggt      480

gtggtgacgc agggtgccag ccgcttggcc agtcatgagt acctgaaggc cttcaaggtg      540

gcctacagcc ttaatggaca cgaattcgat ttcatccatg atgttaataa aaaacacaag      600

gagtttgtgg gtaactggaa caaaaacgcg gtgcatgtca acctgtttga gacccctgtg      660

gaggctcagt acgtgagatt gtaccccacg agctgccaca cggcctgcac tctgcgcttt      720

gagctactgg gctgtgagct gaacggatgc gccaatcccc tgggcctgaa gaataacagc      780

atccctgaca agcagatcac ggcctccagc agctacaaga cctggggctt gcatctcttc      840

agctggaacc cctcctatgc acggctggac aagcagggca acttcaacgc ctgggttgcg      900

gggagctacg gtaacgatca gtggctgcag gtggacctgg gctcctcgaa ggaggtgaca      960

ggcatcatca cccagggggc ccgtaacttt ggctctgtcc agtttgtggc atcctacaag     1020

gttgcctaca gtaatgacag tgcgaactgg actgagtacc aggaccccag gactggcagc     1080

agtaagatct tccctggcaa ctgggacaac cactcccaca agaagaactt gtttgagacg     1140

cccatcctgg ctcgctatgt gcgcatcctg cctgtagcct ggcacaaccg catcgccctg     1200

cgcctggagc tgctgggctg ttagtggcca cctgccaccc ccaggtcttc ctgctttcca     1260

tgggcccgct gcctcttggc ttctcagccc ctttaaatca ccatagggct ggggactggg     1320

gaaggggagg gtgttcagag gcagcaccac cacacagtca cccctccctc cctctttccc     1380

accctccacc tctcacgggc cctgccccag cccctaagcc ccgtccccta acccccagtc     1440

ctcactgtcc tgttttctta ggcactgagg gatctgagta ggtctgggat ggacaggaaa     1500

gggcaaagta gggcgtgtgg tttccctgcc cctgtccgga ccgccgatcc caggtgcgtg     1560

tgtctctgtc tctcctagcc cctctctcac acatcacatt cccatggtgg cctcaagaaa     1620

ggcccggaag cgccaggctg gagataacag cctcttgccc gtcggccctg cgtcggccct     1680

ggggtaccat gtggccacaa ctgctgtggc cccctgtccc caagacactt ccccttgtct     1740

ccctggttgc ctctcttgcc ccttgtcctg aagcccagcg acacagaagg gggtggggcg     1800

ggtctatggg gagaaaggga gcgaggtcag aggagggcat gggttggcag ggtgggcgtt     1860

tggggccctc tatgctggct tttcacccca gaggacacag gcagcttcca aaatatattt     1920

atcttcttca cgggaa                                                     1936


<210> 200
<211> 387
<212> PRT
<213> Homo sapiens

<400> 200
Met Pro Arg Pro Arg Leu Leu Ala Ala Leu Cys Gly Ala Leu Leu Cys 
1               5                   10                  15      


Ala Pro Ser Leu Leu Val Ala Leu Asp Ile Cys Ser Lys Asn Pro Cys 
            20                  25                  30          


His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly Asp 
        35                  40                  45              


Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala Gly Asn 
    50                  55                  60                  


His Cys Glu Thr Lys Cys Val Glu Pro Leu Gly Leu Glu Asn Gly Asn 
65                  70                  75                  80  


Ile Ala Asn Ser Gln Ile Ala Ala Ser Ser Val Arg Val Thr Phe Leu 
                85                  90                  95      


Gly Leu Gln His Trp Val Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly 
            100                 105                 110         


Met Val Asn Ala Trp Thr Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile 
        115                 120                 125             


Gln Val Asn Leu Leu Arg Arg Met Trp Val Thr Gly Val Val Thr Gln 
    130                 135                 140                 


Gly Ala Ser Arg Leu Ala Ser His Glu Tyr Leu Lys Ala Phe Lys Val 
145                 150                 155                 160 


Ala Tyr Ser Leu Asn Gly His Glu Phe Asp Phe Ile His Asp Val Asn 
                165                 170                 175     


Lys Lys His Lys Glu Phe Val Gly Asn Trp Asn Lys Asn Ala Val His 
            180                 185                 190         


Val Asn Leu Phe Glu Thr Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr 
        195                 200                 205             


Pro Thr Ser Cys His Thr Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly 
    210                 215                 220                 


Cys Glu Leu Asn Gly Cys Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser 
225                 230                 235                 240 


Ile Pro Asp Lys Gln Ile Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly 
                245                 250                 255     


Leu His Leu Phe Ser Trp Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln 
            260                 265                 270         


Gly Asn Phe Asn Ala Trp Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp 
        275                 280                 285             


Leu Gln Val Asp Leu Gly Ser Ser Lys Glu Val Thr Gly Ile Ile Thr 
    290                 295                 300                 


Gln Gly Ala Arg Asn Phe Gly Ser Val Gln Phe Val Ala Ser Tyr Lys 
305                 310                 315                 320 


Val Ala Tyr Ser Asn Asp Ser Ala Asn Trp Thr Glu Tyr Gln Asp Pro 
                325                 330                 335     


Arg Thr Gly Ser Ser Lys Ile Phe Pro Gly Asn Trp Asp Asn His Ser 
            340                 345                 350         


His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala Arg Tyr Val Arg 
        355                 360                 365             


Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu Arg Leu Glu Leu 
    370                 375                 380                 


Leu Gly Cys 
385         


<210> 201
<211> 2221
<212> DNA
<213> Homo sapiens

<400> 201
gcattgcggc ttggttttct cacccagtgc atgtggcagg agcggtgaga tcactgcctc       60

acggcgatcc tggactgacg gtcacgactg cctaccctct aaccctgttc tgagctgccc      120

cttgcccaca caccccaaac ctgtgtgcag gatccgcctc catggagcta cagcctcctg      180

aagcctcgat cgccgtcgtg tcgattccgc gccagttgcc tggctcacat tcggaggctg      240

gtgtccaggg tctcagcgcg ggggacgact cagagttggg gtctcactgt gttgcccaga      300

ctggtctcga actcttggcc tcaggtgatc ctcttccctc agcttcccag aatgccgaga      360

tgatagagac ggggtctgac tgtgttaccc aggctggtct tcaactcttg gcctcaagtg      420

atcctcctgc cttagcttcc aagaatgctg aggttacagg caccatgagc caggacaccg      480

aggtggatat gaaggaggtg gagctgaatg agttagagcc cgagaagcag ccgatgaacg      540

cggcgtctgg ggcggccatg tccctggcgg gagccgagaa gaatggtctg gtgaagatca      600

aggtggcgga agacgaggcg gaggcggcag ccgcggctaa gttcacgggc ctgtccaagg      660

aggagctgct gaaggtggca ggcagccccg gctgggtacg cacccgctgg gcactgctgc      720

tgctcttctg gctcggctgg ctcggcatgc ttgctggtgc cgtggtcata atcgtgcgag      780

cgccgcgttg tcgcgagcta ccggcgcaga agtggtggca cacgggcgcc ctctaccgca      840

tcggcgacct tcaggccttc cagggccacg gcgcgggcaa cctggcgggt ctgaaggggc      900

gtctcgatta cctgagctct ctgaaggtga agggccttgt gctgggtcca attcacaaga      960

accagaagga tgatgtcgct cagactgact tgctgcagat cgaccccaat tttggctcca     1020

aggaagattt tgacagtctc ttgcaatcgg ctaaaaaaaa gagcatccgt gtcattctgg     1080

accttactcc caactaccgg ggtgagaact cgtggttctc cactcaggtt gacactgtgg     1140

ccaccaaggt gaaggatgct ctggagtttt ggctgcaagc tggcgtggat gggttccagg     1200

ttcgggacat agagaatctg aaggatgcat cctcattctt ggctgagtgg caaaatatca     1260

ccaagggctt cagtgaagac aggctcttga ttgcggggac taactcctcc gaccttcagc     1320

agatcctgag cctactcgaa tccaacaaag acttgctgtt gactagctca tacctgtctg     1380

attctggttc tactggggag catacaaaat ccctagtcac acagtatttg aatgccactg     1440

gcaatcgctg gtgcagctgg agtttgtctc aggcaaggct cctgacttcc ttcttgccgg     1500

ctcaacttct ccgactctac cagctgatgc tcttcaccct gccagggacc cctgttttca     1560

gctacgggga tgagattggc ctggatgcag ctgcccttcc tggacagcct atggaggctc     1620

cagtcatgct gtgggatgag tccagcttcc ctgacatccc aggggctgta agtgccaaca     1680

tgactgtgaa gggccagagt gaagaccctg gctccctcct ttccttgttc cggcggctga     1740

gtgaccagcg gagtaaggag cgctccctac tgcatgggga cttccacgcg ttctccgctg     1800

ggcctggact cttctcctat atccgccact gggaccagaa tgagcgtttt ctggtagtgc     1860

ttaactttgg ggatgtgggc ctctcggctg gactgcaggc ctccgacctg cctgccagcg     1920

ccagcctgcc agccaaggct gacctcctgc tcagcaccca gccaggccgt gaggagggct     1980

cccctcttga gctggaacgc ctgaaactgg agcctcacga agggctgctg ctccgcttcc     2040

cctacgcggc ctgacttcag cctgacatgg acccactacc cttctccttt ccttcccagg     2100

ccctttggct tctgattttt ctctttttta aaaacaaaca aacaaactgt tgcagattat     2160

gagtgaaccc ccaaataggg tgttttctgc cttcaaataa aagtcacccc tgcatggtga     2220

a                                                                     2221


<210> 202
<211> 630
<212> PRT
<213> Homo sapiens

<400> 202
Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210> 203
<211> 2886
<212> DNA
<213> Homo sapiens

<400> 203
atcgctgggg gacagcctgc aggcttcagg aggggacaca agcatggagc ggctttgggg       60

tctattccag agagcgcaac aactgtcccc aagatcctct cagaccgtct accagcgtgt      120

ggaaggcccc cggaaagggc acctggagga ggaagaggaa gacggggagg agggggcgga      180

gacattggcc cacttctgcc ccatggagct gaggggccct gagcccctgg gctctagacc      240

caggcagcca aacctcattc cctgggcggc agcaggacgg agggctgccc cctacctggt      300

cctgacggcc ctgctgatct tcactggggc cttcctactg ggctacgtcg ccttccgagg      360

gtcctgccag gcgtgcggag actctgtgtt ggtggtcagt gaggatgtca actatgagcc      420

tgacctggat ttccaccagg gcagactcta ctggagcgac ctccaggcca tgttcctgca      480

gttcctgggg gaggggcgcc tggaggacac catcaggcaa accagccttc gggaacgggt      540

ggcaggctcg gccgggatgg ccgctctgac tcaggacatt cgcgcggcgc tctcccgcca      600

gaagctggac cacgtgtgga ccgacacgca ctacgtgggg ctgcaattcc cggatccggc      660

tcaccccaac accctgcact gggtcgatga ggccgggaag gtcggagagc agctgccgct      720

ggaggaccct gacgtctact gcccctacag cgccatcggc aacgtcacgg gagagctggt      780

gtacgcccac tacgggcggc ccgaagacct gcaggacctg cgggccaggg gcgtggatcc      840

agtgggccgc ctgctgctgg tgcgcgtggg ggtgatcagc ttcgcccaga aggtgaccaa      900

tgctcaggac ttcggggctc aaggagtgct catataccca gagccagcgg acttctccca      960

ggacccaccc aagccaagcc tgtccagcca gcaggcagtg tatggacatg tgcacctggg     1020

aactggagac ccctacacac ctggcttccc ttccttcaat caaacccagt tccctccagt     1080

tgcatcatca ggccttccca gcatcccagc ccagcccatc agtgcagaca ttgcctcccg     1140

cctgctgagg aagctcaaag gccctgtggc cccccaagaa tggcagggga gcctcctagg     1200

ctccccttat cacctgggcc ccgggccacg actgcggcta gtggtcaaca atcacaggac     1260

ctccaccccc atcaacaaca tcttcggctg catcgaaggc cgctcagagc cagatcacta     1320

cgttgtcatc ggggcccaga gggatgcatg gggcccagga gcagctaaat ccgctgtggg     1380

gacggctata ctcctggagc tggtgcggac cttttcctcc atggtgagca acggcttccg     1440

gccccgcaga agtctcctct tcatcagctg ggacggtggt gactttggaa gcgtgggctc     1500

cacggagtgg ctagagggct acctcagcgt gctgcacctc aaagccgtag tgtacgtgag     1560

cctggacaac gcagtgctgg gggatgacaa gtttcatgcc aagaccagcc cccttctgac     1620

aagtctcatt gagagtgtcc tgaagcaggt ggattctccc aaccacagtg ggcagactct     1680

ctatgaacag gtggtgttca ccaatcccag ctgggatgct gaggtgatcc ggcccctacc     1740

catggacagc agtgcctatt ccttcacggc ctttgtggga gtccctgccg tcgagttctc     1800

ctttatggag gacgaccagg cctacccatt cctgcacaca aaggaggaca cttatgagaa     1860

cctgcataag gtgctgcaag gccgcctgcc cgccgtggcc caggccgtgg cccagctcgc     1920

agggcagctc ctcatccggc tcagccacga tcgcctgctg cccctcgact tcggccgcta     1980

cggggacgtc gtcctcaggc acatcgggaa cctcaacgag ttctctgggg acctcaaggc     2040

ccgcgggctg accctgcagt gggtgtactc ggcgcggggg gactacatcc gggcggcgga     2100

aaagctgcgg caggagatct acagctcgga ggagagagac gagcgactga cacgcatgta     2160

caacgtgcgc ataatgcggg tggagttcta cttcctttcc cagtacgtgt cgccagccga     2220

ctccccgttc cgccacatct tcatgggccg tggagaccac acgctgggcg ccctgctgga     2280

ccacctgcgg ctgctgcgct ccaacagctc cgggaccccc ggggccacct cctccactgg     2340

cttccaggag agccgtttcc ggcgtcagct agccctgctc acctggacgc tgcaaggggc     2400

agccaatgcg cttagcgggg atgtctggaa cattgataac aacttctgag gccctgggga     2460

tcctcacatc cccgtccccc agtcaagagc tcctctgctc ctcgcttgaa tgattcaggg     2520

tcagggaggt ggctcagagt ccacctctca ttgctgatca atttctcatt acccctacac     2580

atctctccac ggagcccaga ccccagcaca gatatccaca caccccagcc ctgcagtgta     2640

gctgacccta atgtgacggt catactgtcg gttaatcaga gagtagcatc ccttcaatca     2700

cagccccttc ccctttctgg ggtcctccat acctagagac cactctggga ggtttgctag     2760

gccctgggac ctggccagct ctgttagtgg gagagatcgc tggcaccata gccttatggc     2820

caacaggtgg tctgtggtga aaggggcgtg gagtttcaat atcaataaac cacctgatat     2880

caataa                                                                2886


<210> 204
<211> 801
<212> PRT
<213> Homo sapiens

<400> 204
Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala Ser Ser Gly Leu Pro 
            340                 345                 350         


Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile Ala Ser Arg Leu Leu 
        355                 360                 365             


Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu Trp Gln Gly Ser Leu 
    370                 375                 380                 


Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro Arg Leu Arg Leu Val 
385                 390                 395                 400 


Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn Asn Ile Phe Gly Cys 
                405                 410                 415     


Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln 
            420                 425                 430         


Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala 
        435                 440                 445             


Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly 
    450                 455                 460                 


Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp 
465                 470                 475                 480 


Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val 
                485                 490                 495     


Leu His Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu 
            500                 505                 510         


Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu 
        515                 520                 525             


Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln 
    530                 535                 540                 


Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu 
545                 550                 555                 560 


Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala 
                565                 570                 575     


Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln 
            580                 585                 590         


Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His 
        595                 600                 605             


Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala Gln Ala Val Ala Gln 
    610                 615                 620                 


Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His Asp Arg Leu Leu Pro 
625                 630                 635                 640 


Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn 
                645                 650                 655     


Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg Gly Leu Thr Leu Gln 
            660                 665                 670         


Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu 
        675                 680                 685             


Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp Glu Arg Leu Thr Arg 
    690                 695                 700                 


Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln 
705                 710                 715                 720 


Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His Ile Phe Met Gly Arg 
                725                 730                 735     


Gly Asp His Thr Leu Gly Ala Leu Leu Asp His Leu Arg Leu Leu Arg 
            740                 745                 750         


Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser Ser Thr Gly Phe Gln 
        755                 760                 765             


Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln 
    770                 775                 780                 


Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn 
785                 790                 795                 800 


Phe 
    


<210> 205
<211> 11158
<212> DNA
<213> Homo sapiens

<400> 205
gttgccggcc cctgaagtgg agcgagaggg aggtgcttcg ccgtttctcc tgccagggga       60

ggtcccggct tcccgtggag gctccggacc aagccccttc agcttctccc tccggatcga      120

tgtgctgctg ttaacccgtg aggaggcggc ggcggcggca gcggcagcgg aagatggtgt      180

tgctgagagt gttaattctg ctcctctcct gggcggcggg gatgggaggt cagtatggga      240

atcctttaaa taaatatatc agacattatg aaggattatc ttacaatgtg gattcattac      300

accaaaaaca ccagcgtgcc aaaagagcag tctcacatga agaccaattt ttacgtctag      360

atttccatgc ccatggaaga catttcaacc tacgaatgaa gagggacact tcccttttca      420

gtgatgaatt taaagtagaa acatcaaata aagtacttga ttatgatacc tctcatattt      480

acactggaca tatttatggt gaagaaggaa gttttagcca tgggtctgtt attgatggaa      540

gatttgaagg attcatccag actcgtggtg gcacatttta tgttgagcca gcagagagat      600

atattaaaga ccgaactctg ccatttcact ctgtcattta tcatgaagat gatattaact      660

atccccataa atacggtcct caggggggct gtgcagatca ttcagtattt gaaagaatga      720

ggaaatacca gatgactggt gtagaggaag taacacagat acctcaagaa gaacatgctg      780

ctaatggtcc agaacttctg aggaaaaaac gtacaacttc agctgaaaaa aatacttgtc      840

agctttatat tcagactgat catttgttct ttaaatatta cggaacacga gaagctgtga      900

ttgcccagat atccagtcat gttaaagcga ttgatacaat ttaccagacc acagacttct      960

ccggaatccg taacatcagt ttcatggtga aacgcataag aatcaataca actgctgatg     1020

agaaggaccc tacaaatcct ttccgtttcc caaatattgg tgtggagaag tttctggaat     1080

tgaattctga gcagaatcat gatgactact gtttggccta tgtcttcaca gaccgagatt     1140

ttgatgatgg cgtacttggt ctggcttggg ttggagcacc ttcaggaagc tctggaggaa     1200

tatgtgaaaa aagtaaactc tattcagatg gtaagaagaa gtccttaaac actggaatta     1260

ttactgttca gaactatggg tctcatgtac ctcccaaagt ctctcacatt acttttgctc     1320

acgaagttgg acataacttt ggatccccac atgattctgg aacagagtgc acaccaggag     1380

aatctaagaa tttgggtcaa aaagaaaatg gcaattacat catgtatgca agagcaacat     1440

ctggggacaa acttaacaac aataaattct cactctgtag tattagaaat ataagccaag     1500

ttcttgagaa gaagagaaac aactgttttg ttgaatctgg ccaacctatt tgtggaaatg     1560

gaatggtaga acaaggtgaa gaatgtgatt gtggctatag tgaccagtgt aaagatgaat     1620

gctgcttcga tgcaaatcaa ccagagggaa gaaaatgcaa actgaaacct gggaaacagt     1680

gcagtccaag tcaaggtcct tgttgtacag cacagtgtgc attcaagtca aagtctgaga     1740

agtgtcggga tgattcagac tgtgcaaggg aaggaatatg taatggcttc acagctctct     1800

gcccagcatc tgaccctaaa ccaaacttca cagactgtaa taggcataca caagtgtgca     1860

ttaatgggca atgtgcaggt tctatctgtg agaaatatgg cttagaggag tgtacgtgtg     1920

ccagttctga tggcaaagat gataaagaat tatgccatgt atgctgtatg aagaaaatgg     1980

acccatcaac ttgtgccagt acagggtctg tgcagtggag taggcacttc agtggtcgaa     2040

ccatcaccct gcaacctgga tccccttgca acgattttag aggttactgt gatgttttca     2100

tgcggtgcag attagtagat gctgatggtc ctctagctag gcttaaaaaa gcaattttta     2160

gtccagagct ctatgaaaac attgctgaat ggattgtggc tcattggtgg gcagtattac     2220

ttatgggaat tgctctgatc atgctaatgg ctggatttat taagatatgc agtgttcata     2280

ctccaagtag taatccaaag ttgcctcctc ctaaaccact tccaggcact ttaaagagga     2340

ggagacctcc acagcccatt cagcaacccc agcgtcagcg gccccgagag agttatcaaa     2400

tgggacacat gagacgctaa ctgcagcttt tgccttggtt cttcctagtg cctacaatgg     2460

gaaaacttca ctccaaagag aaacctatta agtcatcatc tccaaactaa accctcacaa     2520

gtaacagttg aagaaaaaat ggcaagagat catatcctca gaccaggtgg aattacttaa     2580

attttaaagc ctgaaaattc caatttgggg gtgggaggtg gaaaaggaac ccaattttct     2640

tatgaacaga tatttttaac ttaatggcac aaagtcttag aatattatta tgtgccccgt     2700

gttccctgtt cttcgttgct gcattttctt cacttgcagg caaacttggc tctcaataaa     2760

cttttaccac aaattgaaat aaatatattt ttttcaactg ccaatcaagg ctaggaggct     2820

cgaccacctc aacattggag acatcacttg ccaatgtaca taccttgtta tatgcagaca     2880

tgtatttctt acgtacactg tacttctgtg tgcaattgta aacagaaatt gcaatatgga     2940

tgtttctttg tattataaaa tttttccgct cttaattaaa aattactgtt taattgacat     3000

actcaggata acagagaatg gtggtattca gtggtccagg attctgtaat gctttacaca     3060

ggcagttttg aaatgaaaat caatttacct ttctgttacg atggagttgg ttttgatact     3120

cattttttct ttatcacatg gctgctacgg gcacaagtga ctatactgaa gaacacagtt     3180

aagtgttgtg caaactggac atagcagcac atactacttc agagttcatg atgtagatgt     3240

ctggtttctg cttacgtctt ttaaactttc taattcaatt ccatttttca attaataggt     3300

gaaattttat tcatgctttg atagaaatta tgtcaatgaa atgattcttt ttatttgtag     3360

cctacttatt tgtgtttttc atatatctga aatatgctaa ttatgttttc tgtctgatat     3420

ggaaaagaaa agctgtgtct ttatcaaaat atttaaacgg ttttttcagc atatcatcac     3480

tgatcattgg taaccactaa agatgagtaa tttgcttaag tagtagttaa aattgtagat     3540

aggccttctg acattttttt tcctaaaatt tttaacagca ttgaaggtga aacagcacaa     3600

tgtcccattc caaatttatt tttgaaacag atgtaaataa ttggcatttt aaagagaaag     3660

caaaaacatt taatgtatta acaggcttat tgctatgcag gaaatagaag gggcattaca     3720

aaaattgaag cttgtgacat atttattgct tctgttttcc aactacatca cttcaactag     3780

aagtaaagct atgattttcc tgacttcaca taggaggcaa atttagagaa agttgtaaag     3840

atttctatgt tttgggtttt tttttttcct tttttttttt aagagtataa ggtttacaca     3900

atcattctca taatgtgacg caagccagca aggccaaaaa tgctagagaa aataacggga     3960

tctcttcctt gtaaacttgt acagtatgtg gtgacttttt caaaatacag ctttttgtac     4020

atgatttaga gacaaatttt gtacatgaaa ccccagatag actataaata attctaaaca     4080

aacaagtagg tagatatgta tgtaattgct tttaaatcat ttaaatgcct ttgtttttgg     4140

actgtgcaaa ggttggaagt gggtttgcat ttctaaaatg gtgactttta ttctgcaaga     4200

gttcttagta acttcttgag tgtggtagac tttggaacat gtaaattttt tgcttgtaat     4260

gttatcctgt ggtaggattt tggcaggtac acacactgcc ctattttatt ttgagtctaa     4320

gttaaatgtt ttctgaaaag agatacatgc actgaactct ttccactgcg aatcaagatg     4380

tggtaatata aaaggatcaa gacaaatgag atctaatact actgtcagtt ttaatgtcca     4440

ctgtgtttta tacagtatct ttttttgttc actttggaaa tttttactaa aaattgcaaa     4500

aaataaagta ttgtgcaaag atgtaaggtt ttttgaaact tgaaatgcat taataaatag     4560

acgattaaat caacttgaag gttctatact ctttgaactc tgagaactat cacaagaagc     4620

ttcccacaag gcagtgtttt cttacagttg tctcttccta caaaagtata gattatcttt     4680

attcttaata ctttggaatc catgtagaaa atttccagtt agatactctg cgtacacaca     4740

ataaaccttt ttaaaacacc caactaatct caactgcatt acattgtttc taatcaatat     4800

tcagtgcttg tcttggtgga agaggtgagt cattttgaaa acttatggtc ttgtttttat     4860

gtgtttttca aagttttgaa tgctaagtac ctcatttatt ttaaaaagcc tagtttaatg     4920

ataagtttgt ttaaaatttt gagccatcat ttttctcttc atagcaaata aggagagaat     4980

tgacatttca gtgttaccta gaaaaggaat tgtaagccca gaataattcc ctgcatgagg     5040

taatctgctt caaattcttt ttttagtcaa ggttagctat aagtaatact tgttaaatga     5100

gtaaatatgt aatactttgt gaattacttt gttaatttag gagcatcaaa tgtatattat     5160

gtttagttat ttatgaaact ctcaatattg attgatttgg gtaattataa attagttatt     5220

tttacttgta attgaatgct taaattctgt ttacagtccg tcctctctcc ctccatccct     5280

ccctccccag ttttataaat tcaggtacca attcacaaac aaaatcagaa ataaaataaa     5340

tttattgact gcttctggat ttagcattcc ctgtagtgtc aagcaatgtc atgcagtttg     5400

gggaagcatt tatttaagga aatgacaact ttctctgatc agtcttgttt tgtgaggtgt     5460

cttcaacact ttatgctttg ggtacttcgt gtttgtcaca gtcttaggat agtgaaatct     5520

gatttgtcca agcggagcaa actactcgac cctcagtcct tgtatttgtc cctgtagtaa     5580

gacctaatta ttattatttc ttaaagatgg gattggtgtc cttggcaact atgaaatttc     5640

ggggcttgtg catgagaagg catttcttat taagtatttc taattgaagg tatcagagtg     5700

tcaagcatta caaacctgga cagttcacct ggaggagtac aagaagagat attcattatc     5760

catatttaaa gggtcaaggt ttcccaaaac cagggtgcaa gccagatgta gttttaaagc     5820

agctgccagg gacagttcat ctttagagaa gtcactaaag ttgtaagaaa ttttagtttc     5880

cccaaaacca ctttcaactt cttagaaact agaaagacaa ttggtttgcc ccacagagga     5940

caacttcagt ttcagcatct ctcatgttgt gttcttgatt aaaaacaact tccatttgat     6000

atacttttcc gtttattacc agtttagttt tttcactatt gtttctgtat tcaactcttt     6060

atatgattag gatagaaatt tagcccttct gttttatatt actatattgt ttgtgtgtct     6120

tagatatata catgtatgta ctattttcag tagaaattca tgtattttat aattggtaag     6180

ttcttcagag catctcttct ataaaaagca acaggatgct aggtaaaacg gagcattgag     6240

caaaatactg attagttttt gctttttcct gaaatctaca ctaaagtgat agggtgtggg     6300

gtaatccaac aaggacaagg tgaattgaac aagaacgaaa tctggaagca gatgaaggag     6360

tactattgat tgggcagacc cagggaagtc aaatcctaaa ccagcagtgg gaacacaaca     6420

gaatggtgta gtttgcactg gtaagatttg ggtacctggc agggctgggt gcggtggctc     6480

acacctgtaa tcccagcact ttgggaggcc aaggcgggtg gatcacttga ggtcaggagt     6540

tcgagaccac cctggccaac atggtgaaac cccgtctcta ctaaaaatac agctgggcgt     6600

ggtggcacat gcttgtaatc ccagctactc gggaggcaga ggcaggagat ttgcttgaac     6660

ccgggaggca gaggcaggag atttgcttga acccaggagg cagaggctgc agtgagccgc     6720

gattgcgcca ttgcactcca gcctgggtga cagagcgaga ctctgtctca aaaaaaaaaa     6780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaattt gagtacctgg cctttgttac     6840

tttttttcta tgtgtgtgac aaaaacataa tatgcacact tttgtaaccc acctttctca     6900

tttaatggta cattgataat gtatatcaca ttaactactc taaatatttc tgtggatgta     6960

tgtttttttt tttcttaacc aatttcccat tgtttggaca tgtaggttcc acattgttta     7020

ttattttaaa caattctaaa gaattttaaa caattcttag gaaaatcctc agcctaataa     7080

tgaaattaat tcctaaaagt ggaattgttg gggtaaaggt tttttgaggg acattgataa     7140

aaattatggt actgtctccc agatagatgt accaagttat actaccacga tttaatatat     7200

atatatatat atattaaatc agagtcccat ccttagaaat ccacatatat gcagccacat     7260

gaatgtatta gaaacaataa tagaagactc atgcttaatt cagttgatta gctttagaca     7320

taattcaaat gcaagtcaaa ttgagtgccc taattgtggt ctcttaagta ccatttttct     7380

tcaagggaac cagactcctt tggataaatc actaattcca cctgtaagaa agaaatgtac     7440

aagaagaacc taggaaacat tgttttgtac cagatcagaa agattcagga ggcaccttag     7500

aagttaccac tggccaaggc tgagataact ttagcatcag caaggataat atctgcaaga     7560

gattgaaact catagtattg tatttaactc tgtgagttaa tgatggtagt ggacagaatt     7620

atagttacct ttgggatacg cttttaaaga aattccaggt aataagagaa atgatagaat     7680

taggatatca ccattttacc cccccaacaa tttatggatc tagacaataa tcgccagtga     7740

ctgctaacct cacaaagtga gagcaatcag attttgtgcc tcctaatgga agtacatata     7800

ccacctatga agcagttctg ccaaaagtca catctcatca tgatgaagcc tcctgatcta     7860

actacccctt cattagaaat acaggggaca gagggacaaa taatatacaa gggactcaat     7920

cagcaaaatc cagactctgg aaaactacaa gacatatggt cctgcttcaa caacagaaat     7980

gcaaagagaa aagacaacga tgggttaaag gagacttaag agctacatct atcaagacaa     8040

tttatggact tatttggata ctgatttgaa caaactgttg agaccattgg aaaaatgtga     8100

aaagtggata tttgatatta aggtttttaa ttatttttag gtgtgataat ggtattgtta     8160

cattttttaa aggacccctt ttagagatgc aaattgaaac acttaaaaaa tgaaatgata     8220

cgatgtataa gtttttgctt aaaaataagg attgaagttg gctggtgtgt gtggatatag     8280

ttgaaacaag attggctgtg agttgataat tattgaagct gggtgatggg cacttgggga     8340

tttattatac tattttctct acctgtgttt atatttgaaa tttttcatag aagttttaaa     8400

atgtggccag ttgtgatggc tcatacctgt aatcccaaca ctttgggagg ccaaggtggg     8460

aggatcactt gagctcagga gttagagacc agcctgggca aaatagtgag actccatctc     8520

aaagaaaaaa aaaaagtgtt ttaaatgtga atcaaattcc tatagaagct gattcattac     8580

tgtttttatt ttagcagtaa ttcatgataa tgacctgtat tcataatgat tttcataatg     8640

attgttttag tggaattaaa cttgaaccag tcaagctaac ataattatat tctgctccag     8700

ttacaatgaa taattaattg atttcaactg ctagggtgaa ctcttgaagc tatcagtcat     8760

ccagcaatct tagcaagcag gccattgggt ccctgtttgc tctgtctctc tctctctctc     8820

tcactgttga agggcttagc taactactta agtaaaatat ttgttctctg ttaaacatgt     8880

caaggagtat ggtcagctta tccacattaa gcctgtgtgt cccacgttgg agtaaatgtt     8940

aagtagctca ctacaataaa ctagattctt ctgccctctc ttgtttaaat gatcatgttc     9000

cctggaggtg gaaatagatc tttaaaaaga tattctgtag ttgtttgttc tcagtgtaaa     9060

aaaatgagaa taatttgata agagtgtagg ttgtcttata taaaaagtgg ttccatttgc     9120

atgaatttta gaaaaatcat tttggaaaaa tgaaggctat gtggttatac tgaacacatt     9180

aagcaatttt attctttatt ttaaatgaat attttattat cgttttcttc ccttgccctt     9240

tgggtatggg agttagcctt tgtgtttcta aatacaacag gccggttttt ataaattaag     9300

gtgtcaatat attcttcatt atttagtttt gtgattgtgg ttagttttca tttttcttaa     9360

gtatctgcta gtagcatctg taattaagtg aagtgacctg ttaaccattt tcctctttct     9420

cctcctttcc tcctccttga aacatatcag agcatgtttg aaattctttg gcttttatgg     9480

tatgcatttg ctgatatgca ttgaccagtt accttactca cagatacttc ttaggcactt     9540

gattgtgcca gggccttggc tagatgataa gaatacagta gtgaacttaa cagtttccct     9600

gccctggtga agcgtatggt cttgtaggtg agatagatat cagataatca tgtgaataaa     9660

tgtacaattc cagctgtgat acatgctgag gaggaggttt ttggtgatcc aagagctgat     9720

catgcagaga taggactgag aaaggagggt gggacgttgt cacagctgat aatgcagaga     9780

taggactgag aaaggagggt gggacatcag gaaggtcaga gaattcctta tgaaagtgat     9840

gcttgagtca aaatatgatg gatgaagaga gtttaaatag attacataga atttttaata     9900

atgtcgattg gttatatact gggcactgat agctgatttt tctttgggga aaggtatgtc     9960

agcctagtca ttcagattcc tttatttttt taaatgtttt ttcatttttt gctttgcatt    10020

gcattcattt gctgaagagc tggcttgtac tttggcaggt gtcatacttg gttattctcc    10080

ttaggatatt ggcccaacaa tctgggagtt gtgaaaggcg cttcgctttt cagacctggg    10140

cgtctgtatc atgactatca taaatttagg attaagacac ctagcctcct accaggatga    10200

atgaggtgtc catgtgacct gctgtgccct ggaattttat acatctttct ctcatagcac    10260

acaccatatt acaatataat cctgcctcat ctaagccaaa ctttcgagag aatcatttac    10320

actcagtggc tacttcagct cccattcact tatcaacctg ctgcaatttt tcacagcccc    10380

caaaggactg cagtctgtgc cttcagggag ctgagggtct agcggaagga aagaaaccag    10440

cagttacagt acagaggggt ttgtgttgga aactctacaa acacaggatg ccctggtagc    10500

tcagaggaag tgcatatcga gcatggtagg taggtagtgg gaagagccaa gatgacttcc    10560

cagaggagaa aagctggacc tgagttttgg agtttcggta aaagtttgct ctaactagtc    10620

caagctgctg tcacaagctt ttagaaatga tgtaaccatg gggcagttga ctgtcgtcat    10680

gttctttgct attttcatga ctctggatgt gcttttccta ttccctggat tgccctttcc    10740

ctcgattcct ctgcaggact gggctttatt aatctccatt tccttgagct tggctatagt    10800

aggtgttcaa taaacatttg ttttgttgtg tgctttgtaa ataggcaatg aagctgattt    10860

cacaagatag gcacaaaagt tagtttcatt acaacacatt accaacagct gtatttttaa    10920

cttttaacat atctcattct aaatcctgtg gcagcacaac ctccttccgt catacctgga    10980

gataaatttt ctttcaaaat ctaatatgca ctgtatttat agaatatgaa acataccgac    11040

catgttttgc aaaaatggga aaggcataac ttagctttgg ggcatgtaag taacaactcc    11100

tgataggaga agaaatgtat tcagaaagct caaattagaa ataaaatggg agactcta      11158


<210> 206
<211> 748
<212> PRT
<213> Homo sapiens

<400> 206
Met Val Leu Leu Arg Val Leu Ile Leu Leu Leu Ser Trp Ala Ala Gly 
1               5                   10                  15      


Met Gly Gly Gln Tyr Gly Asn Pro Leu Asn Lys Tyr Ile Arg His Tyr 
            20                  25                  30          


Glu Gly Leu Ser Tyr Asn Val Asp Ser Leu His Gln Lys His Gln Arg 
        35                  40                  45              


Ala Lys Arg Ala Val Ser His Glu Asp Gln Phe Leu Arg Leu Asp Phe 
    50                  55                  60                  


His Ala His Gly Arg His Phe Asn Leu Arg Met Lys Arg Asp Thr Ser 
65                  70                  75                  80  


Leu Phe Ser Asp Glu Phe Lys Val Glu Thr Ser Asn Lys Val Leu Asp 
                85                  90                  95      


Tyr Asp Thr Ser His Ile Tyr Thr Gly His Ile Tyr Gly Glu Glu Gly 
            100                 105                 110         


Ser Phe Ser His Gly Ser Val Ile Asp Gly Arg Phe Glu Gly Phe Ile 
        115                 120                 125             


Gln Thr Arg Gly Gly Thr Phe Tyr Val Glu Pro Ala Glu Arg Tyr Ile 
    130                 135                 140                 


Lys Asp Arg Thr Leu Pro Phe His Ser Val Ile Tyr His Glu Asp Asp 
145                 150                 155                 160 


Ile Asn Tyr Pro His Lys Tyr Gly Pro Gln Gly Gly Cys Ala Asp His 
                165                 170                 175     


Ser Val Phe Glu Arg Met Arg Lys Tyr Gln Met Thr Gly Val Glu Glu 
            180                 185                 190         


Val Thr Gln Ile Pro Gln Glu Glu His Ala Ala Asn Gly Pro Glu Leu 
        195                 200                 205             


Leu Arg Lys Lys Arg Thr Thr Ser Ala Glu Lys Asn Thr Cys Gln Leu 
    210                 215                 220                 


Tyr Ile Gln Thr Asp His Leu Phe Phe Lys Tyr Tyr Gly Thr Arg Glu 
225                 230                 235                 240 


Ala Val Ile Ala Gln Ile Ser Ser His Val Lys Ala Ile Asp Thr Ile 
                245                 250                 255     


Tyr Gln Thr Thr Asp Phe Ser Gly Ile Arg Asn Ile Ser Phe Met Val 
            260                 265                 270         


Lys Arg Ile Arg Ile Asn Thr Thr Ala Asp Glu Lys Asp Pro Thr Asn 
        275                 280                 285             


Pro Phe Arg Phe Pro Asn Ile Gly Val Glu Lys Phe Leu Glu Leu Asn 
    290                 295                 300                 


Ser Glu Gln Asn His Asp Asp Tyr Cys Leu Ala Tyr Val Phe Thr Asp 
305                 310                 315                 320 


Arg Asp Phe Asp Asp Gly Val Leu Gly Leu Ala Trp Val Gly Ala Pro 
                325                 330                 335     


Ser Gly Ser Ser Gly Gly Ile Cys Glu Lys Ser Lys Leu Tyr Ser Asp 
            340                 345                 350         


Gly Lys Lys Lys Ser Leu Asn Thr Gly Ile Ile Thr Val Gln Asn Tyr 
        355                 360                 365             


Gly Ser His Val Pro Pro Lys Val Ser His Ile Thr Phe Ala His Glu 
    370                 375                 380                 


Val Gly His Asn Phe Gly Ser Pro His Asp Ser Gly Thr Glu Cys Thr 
385                 390                 395                 400 


Pro Gly Glu Ser Lys Asn Leu Gly Gln Lys Glu Asn Gly Asn Tyr Ile 
                405                 410                 415     


Met Tyr Ala Arg Ala Thr Ser Gly Asp Lys Leu Asn Asn Asn Lys Phe 
            420                 425                 430         


Ser Leu Cys Ser Ile Arg Asn Ile Ser Gln Val Leu Glu Lys Lys Arg 
        435                 440                 445             


Asn Asn Cys Phe Val Glu Ser Gly Gln Pro Ile Cys Gly Asn Gly Met 
    450                 455                 460                 


Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp Gln Cys Lys 
465                 470                 475                 480 


Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg Lys Cys Lys 
                485                 490                 495     


Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro Cys Cys Thr 
            500                 505                 510         


Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg Asp Asp Ser 
        515                 520                 525             


Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala Leu Cys Pro 
    530                 535                 540                 


Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg His Thr Gln 
545                 550                 555                 560 


Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu Lys Tyr Gly 
                565                 570                 575     


Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp Asp Lys Glu 
            580                 585                 590         


Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser Thr Cys Ala 
        595                 600                 605             


Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly Arg Thr Ile 
    610                 615                 620                 


Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly Tyr Cys Asp 
625                 630                 635                 640 


Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro Leu Ala Arg 
                645                 650                 655     


Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn Ile Ala Glu 
            660                 665                 670         


Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly Ile Ala Leu 
        675                 680                 685             


Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val His Thr Pro 
    690                 695                 700                 


Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro Gly Thr Leu 
705                 710                 715                 720 


Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln Arg Gln Arg 
                725                 730                 735     


Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
            740                 745             


<210> 207
<211> 1225
<212> DNA
<213> Homo sapiens

<400> 207
agccgcctgc atctgtatcc agcgccaggt cccgccagtc ccagctgcgc gcgcccccca       60

gtcccgcacc cgttcggccc aggctaagtt agccctcacc atgccggtca aaggaggcac      120

caagtgcatc aaatacctgc tgttcggatt taacttcatc ttctggcttg ccgggattgc      180

tgtccttgcc attggactat ggctccgatt cgactctcag accaagagca tcttcgagca      240

agaaactaat aataataatt ccagcttcta cacaggagtc tatattctga tcggagccgg      300

cgccctcatg atgctggtgg gcttcctggg ctgctgcggg gctgtgcagg agtcccagtg      360

catgctggga ctgttcttcg gcttcctctt ggtgatattc gccattgaaa tagctgcggc      420

catctgggga tattcccaca aggatgaggt gattaaggaa gtccaggagt tttacaagga      480

cacctacaac aagctgaaaa ccaaggatga gccccagcgg gaaacgctga aagccatcca      540

ctatgcgttg aactgctgtg gtttggctgg gggcgtggaa cagtttatct cagacatctg      600

ccccaagaag gacgtactcg aaaccttcac cgtgaagtcc tgtcctgatg ccatcaaaga      660

ggtcttcgac aataaattcc acatcatcgg cgcagtgggc atcggcattg ccgtggtcat      720

gatatttggc atgatcttca gtatgatctt gtgctgtgct atccgcagga accgcgagat      780

ggtctagagt cagcttacat ccctgagcag gaaagtttac ccatgaagat tggtgggatt      840

ttttgtttgt ttgttttgtt ttgtttgttg tttgttgttt gtttttttgc cactaatttt      900

agtattcatt ctgcattgct agataaaagc tgaagttact ttatgtttgt cttttaatgc      960

ttcattcaat attgacattt gtagttgagc ggggggtttg gtttgctttg gtttatattt     1020

tttcagttgt ttgtttttgc ttgttatatt aagcagaaat cctgcaatga aaggtactat     1080

atttgctaga ctctagacaa gatattgtac ataaaagaat ttttttgtct ttaaatagat     1140

acaaatgtct atcaacttta atcaagttgt aacttatatt gaagacaatt tgatacataa     1200

taaaaaatta tgacaatgtc ctgga                                           1225


<210> 208
<211> 228
<212> PRT
<213> Homo sapiens

<400> 208
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly 
1               5                   10                  15      


Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly 
            20                  25                  30          


Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu 
        35                  40                  45              


Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile 
    50                  55                  60                  


Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly 
65                  70                  75                  80  


Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu 
                85                  90                  95      


Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser 
            100                 105                 110         


His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr 
        115                 120                 125             


Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys 
    130                 135                 140                 


Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu 
145                 150                 155                 160 


Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe 
                165                 170                 175     


Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys 
            180                 185                 190         


Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile 
        195                 200                 205             


Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn 
    210                 215                 220                 


Arg Glu Met Val 
225             


<210> 209
<211> 1847
<212> DNA
<213> Homo sapiens

<400> 209
agtcggctcg agtactcccc gtaacgagga ggtgttctcg gccgtcccac ccttcactgc       60

cgtctccggg ctgcgccgcc ggagccggga cgcgcctccg cagccctcgc cgcctccatc      120

cccgcggccg cagctcctct cgccgtccgc gcgcacacca tgacgaagaa cgagaagaag      180

tccctcaacc agagcctggc cgagtggaag ctcttcatct acaacccgac caccggagaa      240

ttcctggggc gcaccgccaa gagctggggt ttgatcttgc tcttctacct agttttttat      300

gggttcctgg ctgcactctt ctcattcacg atgtgggtta tgcttcagac tctcaacgat      360

gaggttccaa aataccgtga ccagattcct agcccaggac tcatggtttt tccaaaacca      420

gtgaccgcat tggaatatac attcagtagg tctgatccaa cttcgtatgc agggtacatt      480

gaagacctta agaagtttct aaaaccatat actttagaag aacagaagaa cctcacagtc      540

tgtcctgatg gagcactttt tgaacagaag ggtccagttt atgttgcatg tcagtttcct      600

atttcattac ttcaagcatg cagtggtatg aatgatcctg attttggcta ttctcaagga      660

aacccttgta ttcttgtgaa aatgaacaga ataattggat taaagcctga aggagtgcca      720

aggatagatt gtgtttcaaa gaatgaagat ataccaaatg tagcagttta tcctcataat      780

ggaatgatag acttaaaata tttcccatat tatgggaaaa aactgcatgt tgggtatcta      840

cagccattgg ttgctgttca ggtcagcttt gctcctaaca acactgggaa agaagtaaca      900

gttgagtgca agattgatgg atcagccaac ctaaaaagtc aggatgatcg tgacaagttt      960

ttgggacgag ttatgttcaa aatcacagca cgtgcatagt atgagtagga tatctccaca     1020

gagtaaatgt tgtgttgtct gtcttcattt tgtaacagct ggaccttcca ttctagaatt     1080

atgagaccac cttggagaaa ggtgtgtggt acatgacatt gggttacatc ataacgtgct     1140

tccagatcat agtgttcagt gtcctctgaa gtaactgcct gttgcctctg ctgccctttg     1200

aaccagtgta cagtcgccag atagggaccg gtgaacacct gattccaaac atgtaggatg     1260

ggggtcttgt cctcttttta tgtggtttaa ttgccaagtg tctaaagctt aatatgccgt     1320

gctatgtaaa tattttatgg atataacaac tgtcatattt tgatgtcaac agagttttag     1380

ggataaaatg gtacccggcc aacatcaagt gactttatag ctgcaagaaa tgtggtatgt     1440

ggagaagttc tgtatgtgag gaaggaaaaa aagaaaataa aagtgtgttt gaaaaatatt     1500

atcttgggtt ctttgtaaaa tttatttttt acatgctgaa ttagcctcga tctttttgat     1560

taagagcaca aacttttttt tgtaaaacat gtaaaaaaaa aaactgggat taatttttag     1620

tgttggaact gcctcttatt ttaggctgta gataaaatag catttttagg ttagccagtg     1680

tgactatgca cctaattttt tatgagatta aattcataag acttaatttg tacaatagtt     1740

tgtgaaatat cttgttactg cttttattta gcagactgtg gactgtaata aagtatataa     1800

attgtgaaat ataaaaactt ggaacttatt caaagcttca aagcaaa                   1847


<210> 210
<211> 279
<212> PRT
<213> Homo sapiens

<400> 210
Met Thr Lys Asn Glu Lys Lys Ser Leu Asn Gln Ser Leu Ala Glu Trp 
1               5                   10                  15      


Lys Leu Phe Ile Tyr Asn Pro Thr Thr Gly Glu Phe Leu Gly Arg Thr 
            20                  25                  30          


Ala Lys Ser Trp Gly Leu Ile Leu Leu Phe Tyr Leu Val Phe Tyr Gly 
        35                  40                  45              


Phe Leu Ala Ala Leu Phe Ser Phe Thr Met Trp Val Met Leu Gln Thr 
    50                  55                  60                  


Leu Asn Asp Glu Val Pro Lys Tyr Arg Asp Gln Ile Pro Ser Pro Gly 
65                  70                  75                  80  


Leu Met Val Phe Pro Lys Pro Val Thr Ala Leu Glu Tyr Thr Phe Ser 
                85                  90                  95      


Arg Ser Asp Pro Thr Ser Tyr Ala Gly Tyr Ile Glu Asp Leu Lys Lys 
            100                 105                 110         


Phe Leu Lys Pro Tyr Thr Leu Glu Glu Gln Lys Asn Leu Thr Val Cys 
        115                 120                 125             


Pro Asp Gly Ala Leu Phe Glu Gln Lys Gly Pro Val Tyr Val Ala Cys 
    130                 135                 140                 


Gln Phe Pro Ile Ser Leu Leu Gln Ala Cys Ser Gly Met Asn Asp Pro 
145                 150                 155                 160 


Asp Phe Gly Tyr Ser Gln Gly Asn Pro Cys Ile Leu Val Lys Met Asn 
                165                 170                 175     


Arg Ile Ile Gly Leu Lys Pro Glu Gly Val Pro Arg Ile Asp Cys Val 
            180                 185                 190         


Ser Lys Asn Glu Asp Ile Pro Asn Val Ala Val Tyr Pro His Asn Gly 
        195                 200                 205             


Met Ile Asp Leu Lys Tyr Phe Pro Tyr Tyr Gly Lys Lys Leu His Val 
    210                 215                 220                 


Gly Tyr Leu Gln Pro Leu Val Ala Val Gln Val Ser Phe Ala Pro Asn 
225                 230                 235                 240 


Asn Thr Gly Lys Glu Val Thr Val Glu Cys Lys Ile Asp Gly Ser Ala 
                245                 250                 255     


Asn Leu Lys Ser Gln Asp Asp Arg Asp Lys Phe Leu Gly Arg Val Met 
            260                 265                 270         


Phe Lys Ile Thr Ala Arg Ala 
        275                 


<210> 211
<211> 5306
<212> DNA
<213> Homo sapiens

<400> 211
ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt       60

ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg      120

caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggtgc gggagagagg      180

cctgctgaaa atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag      240

tgccttgacg atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga      300

ggattcctac aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga      360

cacagcaggt caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg      420

ctttctttgt gtatttgcca taaataatac taaatcattt gaagatattc accattatag      480

agaacaaatt aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa      540

atgtgatttg ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta      600

tggaattcct tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta      660

tacattagtt cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa      720

gaaaaagaag tcaaagacaa agtgtgtaat tatgtaaata caatttgtac ttttttctta      780

aggcatacta gtacaagtgg taatttttgt acattacact aaattattag catttgtttt      840

agcattacct aatttttttc ctgctccatg cagactgtta gcttttacct taaatgctta      900

ttttaaaatg acagtggaag tttttttttc ctctaagtgc cagtattccc agagttttgg      960

tttttgaact agcaatgcct gtgaaaaaga aactgaatac ctaagatttc tgtcttgggg     1020

cttttggtgc atgcagttga ttacttctta tttttcttac caattgtgaa tgttggtgtg     1080

aaacaaatta atgaagcttt tgaatcatcc ctattctgtg ttttatctag tcacataaat     1140

ggattaatta ctaatttcag ttgagacctt ctaattggtt tttactgaaa cattgaggga     1200

acacaaattt atgggcttcc tgatgatgat tcttctaggc atcatgtcct atagtttgtc     1260

atccctgatg aatgtaaagt tacactgttc acaaaggttt tgtctccttt ccactgctat     1320

tagtcatggt cactctcccc aaaatattat attttttcta taaaaagaaa aaaatggaaa     1380

aaaattacaa ggcaatggaa actattataa ggccatttcc ttttcacatt agataaatta     1440

ctataaagac tcctaatagc ttttcctgtt aaggcagacc cagtatgaaa tggggattat     1500

tatagcaacc attttggggc tatatttaca tgctactaaa tttttataat aattgaaaag     1560

attttaacaa gtataaaaaa ttctcatagg aattaaatgt agtctccctg tgtcagactg     1620

ctctttcata gtataacttt aaatcttttc ttcaacttga gtctttgaag atagttttaa     1680

ttctgcttgt gacattaaaa gattatttgg gccagttata gcttattagg tgttgaagag     1740

accaaggttg caaggccagg ccctgtgtga acctttgagc tttcatagag agtttcacag     1800

catggactgt gtccccacgg tcatccagtg ttgtcatgca ttggttagtc aaaatgggga     1860

gggactaggg cagtttggat agctcaacaa gatacaatct cactctgtgg tggtcctgct     1920

gacaaatcaa gagcattgct tttgtttctt aagaaaacaa actctttttt aaaaattact     1980

tttaaatatt aactcaaaag ttgagatttt ggggtggtgg tgtgccaaga cattaatttt     2040

ttttttaaac aatgaagtga aaaagtttta caatctctag gtttggctag ttctcttaac     2100

actggttaaa ttaacattgc ataaacactt ttcaagtctg atccatattt aataatgctt     2160

taaaataaaa ataaaaacaa tccttttgat aaatttaaaa tgttacttat tttaaaataa     2220

atgaagtgag atggcatggt gaggtgaaag tatcactgga ctaggaagaa ggtgacttag     2280

gttctagata ggtgtctttt aggactctga ttttgaggac atcacttact atccatttct     2340

tcatgttaaa agaagtcatc tcaaactctt agtttttttt ttttacaact atgtaattta     2400

tattccattt acataaggat acacttattt gtcaagctca gcacaatctg taaattttta     2460

acctatgtta caccatcttc agtgccagtc ttgggcaaaa ttgtgcaaga ggtgaagttt     2520

atatttgaat atccattctc gttttaggac tcttcttcca tattagtgtc atcttgcctc     2580

cctaccttcc acatgcccca tgacttgatg cagttttaat acttgtaatt cccctaacca     2640

taagatttac tgctgctgtg gatatctcca tgaagttttc ccactgagtc acatcagaaa     2700

tgccctacat cttatttcct cagggctcaa gagaatctga cagataccat aaagggattt     2760

gacctaatca ctaattttca ggtggtggct gatgctttga acatctcttt gctgcccaat     2820

ccattagcga cagtaggatt tttcaaacct ggtatgaata gacagaaccc tatccagtgg     2880

aaggagaatt taataaagat agtgctgaaa gaattcctta ggtaatctat aactaggact     2940

actcctggta acagtaatac attccattgt tttagtaacc agaaatcttc atgcaatgaa     3000

aaatacttta attcatgaag cttacttttt ttttttggtg tcagagtctc gctcttgtca     3060

cccaggctgg aatgcagtgg cgccatctca gctcactgca acctccatct cccaggttca     3120

agcgattctc gtgcctcggc ctcctgagta gctgggatta caggcgtgtg ccactacact     3180

caactaattt ttgtattttt aggagagacg gggtttcacc ctgttggcca ggctggtctc     3240

gaactcctga cctcaagtga ttcacccacc ttggcctcat aaacctgttt tgcagaactc     3300

atttattcag caaatattta ttgagtgcct accagatgcc agtcaccaca caaggcactg     3360

ggtatatggt atccccaaac aagagacata atcccggtcc ttaggtagtg ctagtgtggt     3420

ctgtaatatc ttactaaggc ctttggtata cgacccagag ataacacgat gcgtatttta     3480

gttttgcaaa gaaggggttt ggtctctgtg ccagctctat aattgttttg ctacgattcc     3540

actgaaactc ttcgatcaag ctactttatg taaatcactt cattgtttta aaggaataaa     3600

cttgattata ttgttttttt atttggcata actgtgattc ttttaggaca attactgtac     3660

acattaaggt gtatgtcaga tattcatatt gacccaaatg tgtaatattc cagttttctc     3720

tgcataagta attaaaatat acttaaaaat taatagtttt atctgggtac aaataaacag     3780

gtgcctgaac tagttcacag acaaggaaac ttctatgtaa aaatcactat gatttctgaa     3840

ttgctatgtg aaactacaga tctttggaac actgtttagg tagggtgtta agacttacac     3900

agtacctcgt ttctacacag agaaagaaat ggccatactt caggaactgc agtgcttatg     3960

aggggatatt taggcctctt gaatttttga tgtagatggg cattttttta aggtagtggt     4020

taattacctt tatgtgaact ttgaatggtt taacaaaaga tttgtttttg tagagatttt     4080

aaagggggag aattctagaa ataaatgtta cctaattatt acagccttaa agacaaaaat     4140

ccttgttgaa gtttttttaa aaaaagctaa attacataga cttaggcatt aacatgtttg     4200

tggaagaata tagcagacgt atattgtatc atttgagtga atgttcccaa gtaggcattc     4260

taggctctat ttaactgagt cacactgcat aggaatttag aacctaactt ttataggtta     4320

tcaaaactgt tgtcaccatt gcacaatttt gtcctaatat atacatagaa actttgtggg     4380

gcatgttaag ttacagtttg cacaagttca tctcatttgt attccattga tttttttttt     4440

cttctaaaca ttttttcttc aaacagtata taactttttt taggggattt ttttttagac     4500

agcaaaaact atctgaagat ttccatttgt caaaaagtaa tgatttcttg ataattgtgt     4560

agtaatgttt tttagaaccc agcagttacc ttaaagctga atttatattt agtaacttct     4620

gtgttaatac tggatagcat gaattctgca ttgagaaact gaatagctgt cataaaatga     4680

aactttcttt ctaaagaaag atactcacat gagttcttga agaatagtca taactagatt     4740

aagatctgtg ttttagttta atagtttgaa gtgcctgttt gggataatga taggtaattt     4800

agatgaattt aggggaaaaa aaagttatct gcagatatgt tgagggccca tctctccccc     4860

cacaccccca cagagctaac tgggttacag tgttttatcc gaaagtttcc aattccactg     4920

tcttgtgttt tcatgttgaa aatacttttg catttttcct ttgagtgcca atttcttact     4980

agtactattt cttaatgtaa catgtttacc tggaatgtat tttaactatt tttgtatagt     5040

gtaaactgaa acatgcacat tttgtacatt gtgctttctt ttgtgggaca tatgcagtgt     5100

gatccagttg ttttccatca tttggttgcg ctgacctagg aatgttggtc atatcaaaca     5160

ttaaaaatga ccactctttt aattgaaatt aacttttaaa tgtttatagg agtatgtgct     5220

gtgaagtgat ctaaaatttg taatattttt gtcatgaact gtactactcc taattattgt     5280

aatgtaataa aaatagttac agtgac                                          5306


<210> 212
<211> 188
<212> PRT
<213> Homo sapiens

<400> 212
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210> 213
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 213
aaaaagaaga aaaagaagaa gaagacaaag tgtgtaatta tg                          42


<210> 214
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 214
Lys Lys Lys Lys Lys Lys Lys Lys Thr Lys Cys Val Ile Met 
1               5                   10                  


<210> 215
<211> 4296
<212> DNA
<213> Homo sapiens

<400> 215
gcacttgggc gttggacccc gcatcttatt agcaaccagg gagatttctc cattttcctc       60

ttgtctacag tgcggctaca aatctgggat ttttttatta cttctttttt tttcgaacta      120

cacttgggct cctttttttg tgctcgactt ttccaccctt tttccctccc tcctgtgctg      180

ctgctttttg atctcttcga ctaaaatttt tttatccgga gtgtatttaa tcggttctgt      240

tctgtcctct ccaccacccc cacccccctc cctccggtgt gtgtgccgct gccgctgttg      300

ccgccgccgc tgctgctgct gctcgccccg tcgttacacc aacccgaggc tctttgtttc      360

ccctcttgga tctgttgagt ttctttgttg aagaagccag catgggtgcc cagttctcca      420

agaccgcagc gaagggagaa gccgccgcgg agaggcctgg ggaggcggct gtggcctcgt      480

cgccttccaa agcgaacgga caggagaatg gccacgtgaa ggtaaacggc gacgcttcgc      540

ccgcggccgc cgagtcgggc gccaaggagg agctgcaggc caacggcagc gccccggccg      600

ccgacaagga ggagcccgcg gccgccggga gcggggcggc gtcgccctcc gcggccgaga      660

aaggtgagcc ggccgccgcc gctgcccccg aggccggggc cagcccggta gagaaggagg      720

cccccgcgga aggcgaggct gccgagcccg gctcgcccac ggccgcggag ggagaggccg      780

cgtcggccgc ctcctcgact tcttcgccca aggccgagga cggggccacg ccctcgccca      840

gcaacgagac cccgaaaaaa aaaaagaagc gcttttcctt caagaagtct ttcaagctga      900

gcggcttctc cttcaagaag aacaagaagg aggctggaga aggcggtgag gctgaggcgc      960

ccgctgccga aggcggcaag gacgaggccg ccgggggcgc agctgcggcc gccgccgagg     1020

cgggcgcggc ctccggggag caggcagcgg cgccgggcga ggaggcggca gcgggcgagg     1080

agggggcggc gggtggcgac ccgcaggagg ccaagcccca ggaggccgct gtcgcgccag     1140

agaagccgcc cgccagcgac gagaccaagg ccgccgagga gcccagcaag gtggaggaga     1200

aaaaggccga ggaggccggg gccagcgccg ccgcctgcga ggccccctcc gccgccgggc     1260

ccggcgcgcc cccggagcag gaggcagccc ccgcggagga gcccgcggcc gccgcagcct     1320

cgtcagcctg cgcagccccc tcacaggagg cccagcccga gtgcagtcca gaagcccccc     1380

cagcggaggc ggcagagtaa aagagcaagc ttttgtgaga taatcgaaga acttttctcc     1440

cccgtttgtt tgttggagtg gtgccaggta ctggttttgg agaacttgtc tacaaccagg     1500

gattgatttt aaagatgtct ttttttattt tacttttttt taagcaccaa attttgttgt     1560

tttttttttt tctcccctcc ccacagatcc catctcaaat cattctgtta accaccattc     1620

caacaggtcg aggagagctt aaacaccttc ttcctctgcc ttgtttctct tttatttttt     1680

attttttcgc atcagtatta atgtttttgc atactttgca tctttattca aaagtgtaaa     1740

ctttctttgt caatctatgg acatgcccat atatgaagga gatgggtggg tcaaaaaggg     1800

atatcaaatg aagtgatggg gtcacaatgg ggaaattgaa gtggtgcata acattgccaa     1860

aatagtgtgc cactagaaat ggtgtaaagg ctgtcttttt ttttttttta aaagaaaagt     1920

tattaccatg tattttgtga ggcaggttta caacactaca agtcttgagt taagaaggaa     1980

agaggaaaaa agaaaaaaca ccaataccca gatttaaaaa aaaaaaaacg atcatagtct     2040

taggagttca tttaaaccat aggaactttt cacttatctc atgttagctg taccagtcag     2100

tgattaagta gaactacaag ttgtataggc tttattgttt attgctggtt tatgacctta     2160

ataaagtgta attatgtatt accagcaggg tgtttttaac tgtgactatt gtataaaaac     2220

aaatcttgat atccagaagc acatgaagtt tgcaactttc caccctgccc atttttgtaa     2280

aactgcagtc atcttggacc ttttaaaaca caaattttaa actcaaccaa gctgtgataa     2340

gtggaatggt tactgtttat actgtggtat gtttttgatt acagcagata atgctttctt     2400

ttccagtcgt ctttgagaat aaaggaaaaa aaatcttcag atgcaatggt tttgtgtagc     2460

atcttgtcta tcatgttttg taaatactgg agaagctttg accaatttga cttagagatg     2520

gaatgtaact ttgcttacaa aaattgctat taaactcctg cttaaggtgt tctaattttc     2580

tgtgagcaca ctaaaagcga aaaataaatg tgaataaaat gtacaaattt gttgtgtttt     2640

tttatgttct aataatactg agacttctag gtcttaggtt aatttttagg aagatcttgc     2700

atgccatcag gagtaaattt tattgtggtt cttaatctga agttttcaag ctctgaaatt     2760

cataatccgc agtgtcagat tacgtagagg aagatcttac aacatttcca tgtcaaatct     2820

gttaccattt attggcattt agttttcatt taagaattga acataattat ttttattgta     2880

gctatatagc atgtcagatt aaatcattta caacaaaagg ggtgtgaacc taagactatt     2940

taaatgtctt atgagaaaat ttcataaagc cattctcttg tcattcaggt ccagaaacaa     3000

attttaaact gagtgagagt ctatagaatc catactgcag atgggtcatg aaatgtgacc     3060

aaatgtgttt caaaaattga tggtgtatta cctgctattg taattgctta gtgcttggct     3120

aatttccaaa ttattgcata atatgttcta ccttaagaaa acaggtttat gtaacaaagt     3180

aatggtgttg aatggatgat gtcagttcat gggcctttag catagtttta agcatccttt     3240

tttttttttt tttttgaaag tgtgttagca tcttgttact caaaggataa gacagacaat     3300

aatacttcac tgaatcttaa taatctttac tagtttacct cctctgctct ttgccacccg     3360

ataactggat atcttttcct tcaaaggacc ctaaactgat tgaaatttaa gatatgtatc     3420

aaaaacatta tttcatttaa tgcacatctg ttttgctgtt tttgagcagt gtgcagttta     3480

gggttcatga taaatcattg aaccacatgt gtaacaactg aatgccaaat cttaaactca     3540

ttagaaaaat aacaaattag gttttgacac gcattcttaa ttggaataat ggatcaaaaa     3600

tagtggttca tgaccttacc aaacaccctt gctactaata aaatcaaata acacttagaa     3660

gggtatgtat ttttagttag ggtttcttga tcttggagga tgtttgaaag ttaaaaattg     3720

aatttggtaa ccaaaggact gatttatggg tctttcctat cttaaccaac gttttcttag     3780

ttacctagat ggccaagtac agtgcctggt atgtagtaag actcagtaaa aaagtggatt     3840

tttaaaaata actcccaaag tgaatagtca aaaatcctgt tagcaaactg ttatatattg     3900

ctaagtttgt tcttttaaca gctggaattt attaagatgc attattttga ttttattcac     3960

tgcctaaaac actttgggtg gtattgatgg agttggtgga ttttcctcca agtgattaaa     4020

tgaaatttga cgtatctttt catccaaagt tttgtacatc atgttttcta acggaaaaaa     4080

atgttaatat ggcttttttg tattactaaa aatagctttg agattaagga aaaataaata     4140

actcttgtac agttcagtat tgtctattaa atctgtattg gcagtatgta taatggcatt     4200

tgctgtggtt acaaaatact tcctctgggt tataataatc atttgatcca attcctattg     4260

cttgtaaaat aaagttttac cagttgatat aatcaa                               4296


<210> 216
<211> 332
<212> PRT
<213> Homo sapiens

<400> 216
Met Gly Ala Gln Phe Ser Lys Thr Ala Ala Lys Gly Glu Ala Ala Ala 
1               5                   10                  15      


Glu Arg Pro Gly Glu Ala Ala Val Ala Ser Ser Pro Ser Lys Ala Asn 
            20                  25                  30          


Gly Gln Glu Asn Gly His Val Lys Val Asn Gly Asp Ala Ser Pro Ala 
        35                  40                  45              


Ala Ala Glu Ser Gly Ala Lys Glu Glu Leu Gln Ala Asn Gly Ser Ala 
    50                  55                  60                  


Pro Ala Ala Asp Lys Glu Glu Pro Ala Ala Ala Gly Ser Gly Ala Ala 
65                  70                  75                  80  


Ser Pro Ser Ala Ala Glu Lys Gly Glu Pro Ala Ala Ala Ala Ala Pro 
                85                  90                  95      


Glu Ala Gly Ala Ser Pro Val Glu Lys Glu Ala Pro Ala Glu Gly Glu 
            100                 105                 110         


Ala Ala Glu Pro Gly Ser Pro Thr Ala Ala Glu Gly Glu Ala Ala Ser 
        115                 120                 125             


Ala Ala Ser Ser Thr Ser Ser Pro Lys Ala Glu Asp Gly Ala Thr Pro 
    130                 135                 140                 


Ser Pro Ser Asn Glu Thr Pro Lys Lys Lys Lys Lys Arg Phe Ser Phe 
145                 150                 155                 160 


Lys Lys Ser Phe Lys Leu Ser Gly Phe Ser Phe Lys Lys Asn Lys Lys 
                165                 170                 175     


Glu Ala Gly Glu Gly Gly Glu Ala Glu Ala Pro Ala Ala Glu Gly Gly 
            180                 185                 190         


Lys Asp Glu Ala Ala Gly Gly Ala Ala Ala Ala Ala Ala Glu Ala Gly 
        195                 200                 205             


Ala Ala Ser Gly Glu Gln Ala Ala Ala Pro Gly Glu Glu Ala Ala Ala 
    210                 215                 220                 


Gly Glu Glu Gly Ala Ala Gly Gly Asp Pro Gln Glu Ala Lys Pro Gln 
225                 230                 235                 240 


Glu Ala Ala Val Ala Pro Glu Lys Pro Pro Ala Ser Asp Glu Thr Lys 
                245                 250                 255     


Ala Ala Glu Glu Pro Ser Lys Val Glu Glu Lys Lys Ala Glu Glu Ala 
            260                 265                 270         


Gly Ala Ser Ala Ala Ala Cys Glu Ala Pro Ser Ala Ala Gly Pro Gly 
        275                 280                 285             


Ala Pro Pro Glu Gln Glu Ala Ala Pro Ala Glu Glu Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Ala Cys Ala Ala Pro Ser Gln Glu Ala Gln Pro Glu 
305                 310                 315                 320 


Cys Ser Pro Glu Ala Pro Pro Ala Glu Ala Ala Glu 
                325                 330         


<210> 217
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 217
atgggttgct gtttctccaa gacc                                              24


<210> 218
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 218
Met Gly Cys Cys Phe Ser Lys Thr 
1               5               


<210> 219
<211> 2079
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 219
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaactcg       60

atatcggcca tggttagatc tgacaaaact cacacatgcc caccgtgccc agcacctgaa      120

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      180

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      240

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      300

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      360

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      420

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      480

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      540

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      600

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac      660

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac      720

aaccactaca cgcagaagag cctctccctg tctccgggta aagccagcgg aagtggcgga      780

ggaggcggtc ctggagaagg tgcctatgta taccgctcag cattcagtgt gggattggag      840

acttacgtta ctatccccaa catgcccatt cgctttacca agatcttcta caatcagcaa      900

aaccactatg atggctccac tggtaaattc cactgcaaca ttcctgggct gtactacttt      960

gcctaccaca tcacagtcta tatgaaggat gtgaaggtca gcctcttcaa gaaggacaag     1020

gctatgctct tcacctatga tcagtaccag gaaaataatg tggaccaggc ctccggctct     1080

gtgctcctgc atctggaggt gggcgaccaa gtctggctcc aggtgtatgg ggaaggagag     1140

cgtaatggac tctatgctga taatgacaat gactccacct tcacaggctt tcttctctac     1200

catgacacca actctagaaa gcttcctgga gaaggtgcct atgtataccg ctcagcattc     1260

agtgtgggat tggagactta cgttactatc cccaacatgc ccattcgctt taccaagatc     1320

ttctacaatc agcaaaacca ctatgatggc tccactggta aattccactg caacattcct     1380

gggctgtact actttgccta ccacatcaca gtctatatga aggatgtgaa ggtcagcctc     1440

ttcaagaagg acaaggctat gctcttcacc tatgatcagt accaggaaaa taatgtggac     1500

caggcctccg gctctgtgct cctgcatctg gaggtgggcg accaagtctg gctccaggtg     1560

tatggggaag gagagcgtaa tggactctat gctgataatg acaatgactc caccttcaca     1620

ggctttcttc tctaccatga caccaacact agtcctggag aaggtgccta tgtataccgc     1680

tcagcattca gtgtgggatt ggagacttac gttactatcc ccaacatgcc cattcgcttt     1740

accaagatct tctacaatca gcaaaaccac tatgatggct ccactggtaa attccactgc     1800

aacattcctg ggctgtacta ctttgcctac cacatcacag tctatatgaa ggatgtgaag     1860

gtcagcctct tcaagaagga caaggctatg ctcttcacct atgatcagta ccaggaaaat     1920

aatgtggacc aggcctccgg ctctgtgctc ctgcatctgg aggtgggcga ccaagtctgg     1980

ctccaggtgt atggggaagg agagcgtaat ggactctatg ctgataatga caatgactcc     2040

accttcacag gctttcttct ctaccatgac accaactaa                            2079


<210> 220
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 220
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 221
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 221
gctactaact tcagcctgct gaagcag                                           27


<210> 222
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 222
Ala Thr Asn Phe Ser Leu Lys Gln Ala Gly Asp Val Glu Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210> 223
<211> 1290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 223
atggcttgcc ttggatttca gcggcacaag gctcagctga acctggctac caggacctgg       60

ccctgcactc tcctgttttt tcttctcttc atccctgtct tctgcaaagc aatgcacgtg      120

gcccagcctg ctgtggtact ggccagcagc cgaggcatcg ccagctttgt gtgtgagtat      180

gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc tgacagccag      240

gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt cctagatgat      300

tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg      360

gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc gccatactac      420

ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg cccagattct      480

gacatcgatg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      540

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      600

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      660

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      720

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      780

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      840

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      900

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      960

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1020

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1080

cagcagggga acgtcttctc atgctccgtg atgcacgagg ctctgcacaa ccactacacg     1140

cagaagagcc tctccctgtc tccgggtaaa atcgatccaa ataaaggaag tggaaccact     1200

tcaggtacta cccgtcttct atctgggcac acgtgtttca cgttgacagg tttgcttggg     1260

acgctagtaa ccatgggctt gctgacttag                                      1290


<210> 224
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 224
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Ile Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr 
385                 390                 395                 400 


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
                405                 410                 415     


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            420                 425                 


<210> 225
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 225
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggccaaat      720

aaaggaagtg gaaccacttc aggtactacc cgtcttctat ctgggcacac gtgtttcacg      780

ttgacaggtt tgcttgggac gctagtaacc atgggcttgc tgacttag                   828


<210> 226
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 226
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Pro Asn 
225                 230                 235                 240 


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
                245                 250                 255     


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
            260                 265                 270         


Leu Leu Thr 
        275 


<210> 227
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 227
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggatcgat      720

gtcgagccac tgggcatgga gaatgggaac attgccaact cacagatcgc cgcctcatct      780

gtgcgtgtga ccttcttggg tttgcagcat tgggtcccgg agctggcccg cctgaaccgc      840

gcaggcatgg tcaatgcctg gacacccagc agcaatgacg ataacccctg gatccaggtg      900

aacctgctgc ggaggatgtg ggtaacaggt gtggtgacgc agggtgccag ccgcttggcc      960

agtcatgagt acctgaaggc cttcaaggtg gcctacagcc ttaatggaca cgaattcgat     1020

ttcatccatg atgttaataa aaaacacaag gagtttgtgg gtaactggaa caaaaacgcg     1080

gtgcatgtca acctgtttga gacccctgtg gaggctcagt acgtgagatt gtaccccacg     1140

agctgccaca cggcctgcac tctgcgcttt gagctactgg gctgtgagct gaacggatgc     1200

gccaatcccc tgggcctgaa gaataacagc atccctgaca agcagatcac ggcctccagc     1260

agctacaaga cctggggctt gcatctcttc agctggaacc cctcctatgc acggctggac     1320

aagcagggca acttcaacgc ctgggttgcg gggagctacg gtaacgatca gtggctgcag     1380

atcttccctg gcaactggga caaccactcc cacaagaaga acttgtttga gacgcccatc     1440

ctggctcgct atgtgcgcat cctgcctgta gcctggcaca accgcatcgc cctgcgcctg     1500

gagctgctgg gctgttag                                                   1518


<210> 228
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 228
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Ile Asp 
225                 230                 235                 240 


Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 
                245                 250                 255     


Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 
            260                 265                 270         


Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 
        275                 280                 285             


Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 
    290                 295                 300                 


Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 
305                 310                 315                 320 


Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 
                325                 330                 335     


His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 
            340                 345                 350         


Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 
        355                 360                 365             


Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 
    370                 375                 380                 


Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 
385                 390                 395                 400 


Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 
                405                 410                 415     


Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 
            420                 425                 430         


Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 
        435                 440                 445             


Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Ile Phe Pro Gly 
    450                 455                 460                 


Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile 
465                 470                 475                 480 


Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile 
                485                 490                 495     


Ala Leu Arg Leu Glu Leu Leu Gly Cys 
            500                 505 


<210> 229
<211> 1521
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 229
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggatcgat      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa aatcgatcca aataaaggaa gtggaaccac ttcaggtact     1440

acccgtcttc tatctgggca cacgtgtttc acgttgacag gtttgcttgg gacgctagta     1500

accatgggct tgctgactta g                                               1521


<210> 230
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 230
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Ile Asp 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr 
465                 470                 475                 480 


Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu 
                485                 490                 495     


Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            500                 505     


<210> 231
<211> 1464
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 231
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta       60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg      120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa      180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg      240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac      300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa      360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag      420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt      480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg      540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg      600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact      660

atcgatgtcg agccactggg catggagaat gggaacattg ccaactcaca gatcgccgcc      720

tcatctgtgc gtgtgacctt cttgggtttg cagcattggg tcccggagct ggcccgcctg      780

aaccgcgcag gcatggtcaa tgcctggaca cccagcagca atgacgataa cccctggatc      840

caggtgaacc tgctgcggag gatgtgggta acaggtgtgg tgacgcaggg tgccagccgc      900

ttggccagtc atgagtacct gaaggccttc aaggtggcct acagccttaa tggacacgaa      960

ttcgatttca tccatgatgt taataaaaaa cacaaggagt ttgtgggtaa ctggaacaaa     1020

aacgcggtgc atgtcaacct gtttgagacc cctgtggagg ctcagtacgt gagattgtac     1080

cccacgagct gccacacggc ctgcactctg cgctttgagc tactgggctg tgagctgaac     1140

ggatgcgcca atcccctggg cctgaagaat aacagcatcc ctgacaagca gatcacggcc     1200

tccagcagct acaagacctg gggcttgcat ctcttcagct ggaacccctc ctatgcacgg     1260

ctggacaagc agggcaactt caacgcctgg gttgcgggga gctacggtaa cgatcagtgg     1320

ctgcagatct tccctggcaa ctgggacaac cactcccaca agaagaactt gtttgagacg     1380

cccatcctgg ctcgctatgt gcgcatcctg cctgtagcct ggcacaaccg catcgccctg     1440

cgcctggagc tgctgggctg ttag                                            1464


<210> 232
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 232
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Ile Asp Val Glu 
    210                 215                 220                 


Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala 
225                 230                 235                 240 


Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu 
                245                 250                 255     


Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser 
            260                 265                 270         


Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met 
        275                 280                 285             


Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His 
    290                 295                 300                 


Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu 
305                 310                 315                 320 


Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly 
                325                 330                 335     


Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val 
            340                 345                 350         


Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys 
        355                 360                 365             


Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn 
    370                 375                 380                 


Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala 
385                 390                 395                 400 


Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro 
                405                 410                 415     


Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala 
            420                 425                 430         


Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Ile Phe Pro Gly Asn Trp 
        435                 440                 445             


Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala 
    450                 455                 460                 


Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu 
465                 470                 475                 480 


Arg Leu Glu Leu Leu Gly Cys 
                485         


<210> 233
<211> 1467
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 233
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta       60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg      120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa      180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg      240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac      300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa      360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag      420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt      480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg      540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg      600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact      660

atcgatgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaaatc gatccaaata aaggaagtgg aaccacttca     1380

ggtactaccc gtcttctatc tgggcacacg tgtttcacgt tgacaggttt gcttgggacg     1440

ctagtaacca tgggcttgct gacttag                                         1467


<210> 234
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 234
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Ile Asp Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
    450                 455                 460                 


Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr 
465                 470                 475                 480 


Leu Val Thr Met Gly Leu Leu Thr 
                485             


<210> 235
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 235
atgagccagg acaccgaggt ggatatgaag gaggtggagc tgaatgagtt agagcccgag       60

aagcagccga tgaacgcggc gtctggggcg gccatgtccc tggcgggagc cgagaagaat      120

ggtctggtga agatcaaggt ggcggaagac gaggcggagg cggcagccgc ggctaagttc      180

acgggcctgt ccaaggagga gctgctgaag gtggcaggca gccccggctg ggtacgcacc      240

cgctgggcac tgctgctgct cttctggctc ggctggctcg gcatgcttgc tggtgccgtg      300

gtcataatcg tggcctgccc ctgggccgtg tccggggctc gcgcctcgcc cggctccgcg      360

gccagcccga gactccgcga gggtcccgag ctttcgcccg acgatcccgc cggcctcttg      420

gacctgcggc agggcatgtt tgcgcagctg gtggcccaaa atgttctgct gatcgatggg      480

cccctgagct ggtacagtga cccaggcctg gcaggcgtgt ccctgacggg gggcctgagc      540

tacaaagagg acacgaagga gctggtggtg gccaaggctg gagtctacta tgtcttcttt      600

caactagagc tgcggcgcgt ggtggccggc gagggctcag gctccgtttc acttgcgctg      660

cacctgcagc cactgcgctc tgctgctggg gccgccgccc tggctttgac cgtggacctg      720

ccacccgcct cctccgaggc tcggaactcg gccttcggtt tccagggccg cttgctgcac      780

ctgagtgccg gccagcgcct gggcgtccat cttcacactg aggccagggc acgccatgcc      840

tggcagctta cccagggcgc cacagtcttg ggactcttcc gggtgacccc cgaaatccca      900

gccggactcc cttcaccgag gtcggaataa                                       930


<210> 236
<211> 309
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 236
Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Ala Cys Pro Trp Ala Val Ser Gly 
            100                 105                 110         


Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
        115                 120                 125             


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
    130                 135                 140                 


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
145                 150                 155                 160 


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                165                 170                 175     


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
            180                 185                 190         


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
        195                 200                 205             


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
    210                 215                 220                 


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
225                 230                 235                 240 


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                245                 250                 255     


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
            260                 265                 270         


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
        275                 280                 285             


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
    290                 295                 300                 


Ser Pro Arg Ser Glu 
305                 


<210> 237
<211> 1515
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 237
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aagggagtcc      720

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gggtcctcac cgtcctgcac caggactggc tgaacggtaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggaggacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctccgggtaa accaaataaa ggaagtggaa ccacttcagg tactacccgt     1440

cttctatctg ggcacacgtg tttcacgttg acaggtttgc ttgggacgct agtaaccatg     1500

ggcttgctga cttag                                                      1515


<210> 238
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 238
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Arg Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asp Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
465                 470                 475                 480 


Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr 
                485                 490                 495     


Leu Val Thr Met Gly Leu Leu Thr 
            500                 


<210> 239
<211> 1941
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 239
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggccaaat      720

aaaggaagtg gaaccacttc aggtactacc cgtcttctat ctgggcacac gtgtttcacg      780

ttgacaggtt tgcttgggac gctagtaacc atgggcttgc tgactggaag cggagctact      840

aacttcagcc tgctgaagca ggctggcgac gtggaggaga accctggacc tatggcaaag      900

gtgttcagtt tcatccttgt taccaccgct ctgacaatgg gcagggaaat ttcggcgctc      960

gaggactgtg cccaggagca gatgcggctc agagcccagg tgcgcctgct tgagacccgg     1020

gtcaaacagc aacaggtcaa gatcaagcag cttttgcagg agaatgaagt ccagttcctt     1080

gataaaggag atgagaatac tgtcattgat cttggaagca agaggcagta tgcagattgt     1140

tcagagattt tcaatgatgg gtataagctc agtggatttt acaaaatcaa acctctccag     1200

agcccagcag aattttctgt ttattgtgac atgtccgatg gaggaggatg gactgtaatt     1260

cagagacgat ctgatggcag tgaaaacttt aacagaggat ggaaagacta tgaaaatggc     1320

tttggaaatt ttgtccaaaa acatggtgaa tattggctgg gcaataaaaa tcttcacttc     1380

ttgaccactc aagaagacta cactttaaaa atcgaccttg cagattttga aaaaaatagc     1440

cgttatgcac aatataagaa tttcaaagtt ggagatgaaa agaatttcta cgagttgaat     1500

attggggaat attctggaac agctggagat tcccttgcgg ggaattttca tcctgaggtg     1560

cagtggtggg ctagtcacca aagaatgaaa ttcagcacgt gggacagaga tcatgacaac     1620

tatgaaggga actgcgcaga agaagatcag tctggctggt ggtttaacag gtgtcactct     1680

gcaaacctga atggtgtata ctacagcggc ccctacacgg ctaaaacaga caatgggatt     1740

gtctggtaca cctggcatgg gtggtggtat tctctgaaat ctgtggttat gaaaattagg     1800

ccaaatgatt ttattccaaa tgtaattcca aataaaggaa gtggaaccac ttcaggtact     1860

acccgtcttc tatctgggca cacgtgtttc acgttgacag gtttgcttgg gacgctagta     1920

accatgggct tgctgactta g                                               1941


<210> 240
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Pro Asn 
225                 230                 235                 240 


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
                245                 250                 255     


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
            260                 265                 270         


Leu Leu Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Lys Val Phe Ser Phe 
    290                 295                 300                 


Ile Leu Val Thr Thr Ala Leu Thr Met Gly Arg Glu Ile Ser Ala Leu 
305                 310                 315                 320 


Glu Asp Cys Ala Gln Glu Gln Met Arg Leu Arg Ala Gln Val Arg Leu 
                325                 330                 335     


Leu Glu Thr Arg Val Lys Gln Gln Gln Val Lys Ile Lys Gln Leu Leu 
            340                 345                 350         


Gln Glu Asn Glu Val Gln Phe Leu Asp Lys Gly Asp Glu Asn Thr Val 
        355                 360                 365             


Ile Asp Leu Gly Ser Lys Arg Gln Tyr Ala Asp Cys Ser Glu Ile Phe 
    370                 375                 380                 


Asn Asp Gly Tyr Lys Leu Ser Gly Phe Tyr Lys Ile Lys Pro Leu Gln 
385                 390                 395                 400 


Ser Pro Ala Glu Phe Ser Val Tyr Cys Asp Met Ser Asp Gly Gly Gly 
                405                 410                 415     


Trp Thr Val Ile Gln Arg Arg Ser Asp Gly Ser Glu Asn Phe Asn Arg 
            420                 425                 430         


Gly Trp Lys Asp Tyr Glu Asn Gly Phe Gly Asn Phe Val Gln Lys His 
        435                 440                 445             


Gly Glu Tyr Trp Leu Gly Asn Lys Asn Leu His Phe Leu Thr Thr Gln 
    450                 455                 460                 


Glu Asp Tyr Thr Leu Lys Ile Asp Leu Ala Asp Phe Glu Lys Asn Ser 
465                 470                 475                 480 


Arg Tyr Ala Gln Tyr Lys Asn Phe Lys Val Gly Asp Glu Lys Asn Phe 
                485                 490                 495     


Tyr Glu Leu Asn Ile Gly Glu Tyr Ser Gly Thr Ala Gly Asp Ser Leu 
            500                 505                 510         


Ala Gly Asn Phe His Pro Glu Val Gln Trp Trp Ala Ser His Gln Arg 
        515                 520                 525             


Met Lys Phe Ser Thr Trp Asp Arg Asp His Asp Asn Tyr Glu Gly Asn 
    530                 535                 540                 


Cys Ala Glu Glu Asp Gln Ser Gly Trp Trp Phe Asn Arg Cys His Ser 
545                 550                 555                 560 


Ala Asn Leu Asn Gly Val Tyr Tyr Ser Gly Pro Tyr Thr Ala Lys Thr 
                565                 570                 575     


Asp Asn Gly Ile Val Trp Tyr Thr Trp His Gly Trp Trp Tyr Ser Leu 
            580                 585                 590         


Lys Ser Val Val Met Lys Ile Arg Pro Asn Asp Phe Ile Pro Asn Val 
        595                 600                 605             


Ile Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu 
    610                 615                 620                 


Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val 
625                 630                 635                 640 


Thr Met Gly Leu Leu Thr 
                645     


<210> 241
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 241
atgggttgct gtttctccaa gaccggctcg agcggcgtga gcaagggcga ggcagtgatc       60

aaggagttca tgcggttcaa ggtgcacatg gagggctcca tgaacggcca cgagttcgag      120

atcgagggcg agggcgaggg ccgcccctac gagggcaccc agaccgccaa gctgaaggtg      180

accaagggtg gccccctgcc cttctcctgg gacatcctgt cccctcagtt catgtacggc      240

tccagggcct tcaccaagca ccccgccgac atccccgact actataagca gtccttcccc      300

gagggcttca agtgggagcg cgtgatgaac ttcgaggacg gcggcgccgt gaccgtgacc      360

caggacacct ccctggagga cggcaccctg atctacaagg tgaagctccg cggcaccaac      420

ttccctcctg acggccccgt aatgcagaag aagacaatgg gctgggaagc gtccaccgag      480

cggttgtacc ccgaggacgg cgtgctgaag ggcgacatta agatggccct gcgcctgaag      540

gacggcggcc gctacctggc ggacttcaag accacctaca aggccaagaa gcccgtgcag      600

atgcccggcg cctacaacgt cgaccgcaag ttggacatca cctcccacaa cgaggactac      660

accgtggtgg aacagtacga acgctccgag ggccgccact ccaccggcgg catggacgag      720

ctgtacaag                                                              729


<210> 242
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Met Gly Cys Cys Phe Ser Lys Thr Gly Ser Ser Gly Val Ser Lys Gly 
1               5                   10                  15      


Glu Ala Val Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly 
            20                  25                  30          


Ser Met Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg 
        35                  40                  45              


Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly 
    50                  55                  60                  


Pro Leu Pro Phe Ser Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 
65                  70                  75                  80  


Ser Arg Ala Phe Thr Lys His Pro Ala Asp Ile Pro Asp Tyr Tyr Lys 
                85                  90                  95      


Gln Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 
            100                 105                 110         


Asp Gly Gly Ala Val Thr Val Thr Gln Asp Thr Ser Leu Glu Asp Gly 
        115                 120                 125             


Thr Leu Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Pro Asp 
    130                 135                 140                 


Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Thr Glu 
145                 150                 155                 160 


Arg Leu Tyr Pro Glu Asp Gly Val Leu Lys Gly Asp Ile Lys Met Ala 
                165                 170                 175     


Leu Arg Leu Lys Asp Gly Gly Arg Tyr Leu Ala Asp Phe Lys Thr Thr 
            180                 185                 190         


Tyr Lys Ala Lys Lys Pro Val Gln Met Pro Gly Ala Tyr Asn Val Asp 
        195                 200                 205             


Arg Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Val Val Glu 
    210                 215                 220                 


Gln Tyr Glu Arg Ser Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu 
225                 230                 235                 240 


Leu Tyr Lys 
            


<210> 243
<211> 549
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 243
atgggttgct gtttctccaa gaccggctcg agcggcgtct tcacactcga agatttcgtt       60

ggggactggc gacagacagc cggctacaac ctggaccaag tccttgaaca gggaggtgtg      120

tccagtttgt ttcagaatct cggggtgtcc gtaactccga tccaaaggat tgtcctgagc      180

ggtgaaaatg ggctgaagat cgacatccat gtcatcatcc cgtatgaagg tctgagcggc      240

gaccaaatgg gccagatcga aaaaattttt aaggtggtgt accctgtgga tgatcatcac      300

tttaaggtga tcctgcacta tggcacactg gtaatcgacg gggttacgcc gaacatgatc      360

gactatttcg gacggccgta tgaaggcatc gccgtgttcg acggcaaaaa gatcactgta      420

acagggaccc tgtggaacgg caacaaaatt atcgacgagc gcctgatcaa ccccgacggc      480

tccctgctgt tccgagtaac catcaacgga gtgaccggct ggcggctgtg cgaacgcatt      540

ctggcgtaa                                                              549


<210> 244
<211> 182
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Met Gly Cys Cys Phe Ser Lys Thr Gly Ser Ser Gly Val Phe Thr Leu 
1               5                   10                  15      


Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
            20                  25                  30          


Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
        35                  40                  45              


Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
    50                  55                  60                  


Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly 
65                  70                  75                  80  


Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val 
                85                  90                  95      


Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile 
            100                 105                 110         


Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu 
        115                 120                 125             


Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu 
    130                 135                 140                 


Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly 
145                 150                 155                 160 


Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu 
                165                 170                 175     


Cys Glu Arg Ile Leu Ala 
            180         


<210> 245
<211> 849
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 245
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc aggtaatatt ctgaatgtgt ccattaaaat atgtctaaca      720

ctgtccccta gcaccccaaa taaaggaagt ggaaccactt caggtactac ccgtcttcta      780

tctgggcaca cgtgtttcac gttgacaggt ttgcttggga cgctagtaac catgggcttg      840

ctgacttag                                                              849


<210> 246
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 246
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr 
                245                 250                 255     


Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu 
            260                 265                 270         


Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
        275                 280         


<210> 247
<211> 939
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 247
atggagcggc tttggggtct attccagaga gcgcaacaac tgtccccaag atcctctcag       60

accgtctacc agcgtgtgga aggcccccgg aaagggcacc tggaggagga agaggaagac      120

ggggaggagg gggcggagac attggcccac ttctgcccca tggagctgag gggccctgag      180

cccctgggct ctagacccag gcagccaaac ctcattccct gggcggcagc aggacggagg      240

gctgccccct acctggtcct gacggccctg ctgatcttca ctggggcctt cctactgggc      300

tacgtcgcct tccgagggtc cgcctgcccc tgggccgtgt ccggggctcg cgcctcgccc      360

ggctccgcgg ccagcccgag actccgcgag ggtcccgagc tttcgcccga cgatcccgcc      420

ggcctcttgg acctgcggca gggcatgttt gcgcagctgg tggcccaaaa tgttctgctg      480

atcgatgggc ccctgagctg gtacagtgac ccaggcctgg caggcgtgtc cctgacgggg      540

ggcctgagct acaaagagga cacgaaggag ctggtggtgg ccaaggctgg agtctactat      600

gtcttctttc aactagagct gcggcgcgtg gtggccggcg agggctcagg ctccgtttca      660

cttgcgctgc acctgcagcc actgcgctct gctgctgggg ccgccgccct ggctttgacc      720

gtggacctgc cacccgcctc ctccgaggct cggaactcgg ccttcggttt ccagggccgc      780

ttgctgcacc tgagtgccgg ccagcgcctg ggcgtccatc ttcacactga ggccagggca      840

cgccatgcct ggcagcttac ccagggcgcc acagtcttgg gactcttccg ggtgaccccc      900

gaaatcccag ccggactccc ttcaccgagg tcggaataa                             939


<210> 248
<211> 311
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 248
Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Ala Cys Pro Trp Ala 
            100                 105                 110         


Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu 
        115                 120                 125             


Arg Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    130                 135                 140                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
145                 150                 155                 160 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                165                 170                 175     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            180                 185                 190         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        195                 200                 205             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    210                 215                 220                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
225                 230                 235                 240 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                245                 250                 255     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            260                 265                 270         


Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
        275                 280                 285             


Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly 
    290                 295                 300                 


Leu Pro Ser Pro Arg Ser Glu 
305                 310     


<210> 249
<211> 741
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 249
atgggctgct gcggggctgt gcaggagtcc cagtgcatgc tgggactgtt cttcggcttc       60

ctcttggtga tattcgccat tgaaatagct gcggccatct ggggatattc ccacaaggat      120

gaggcctgcc cctgggccgt gtccggggct cgcgcctcgc ccggctccgc ggccagcccg      180

agactccgcg agggtcccga gctttcgccc gacgatcccg ccggcctctt ggacctgcgg      240

cagggcatgt ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc      300

tggtacagtg acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag      360

gacacgaagg agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag      420

ctgcggcgcg tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag      480

ccactgcgct ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc      540

tcctccgagg ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc      600

ggccagcgcc tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt      660

acccagggcg ccacagtctt gggactcttc cgggtgaccc ccgaaatccc agccggactc      720

ccttcaccga ggtcggaata a                                                741


<210> 250
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 250
Met Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu 
1               5                   10                  15      


Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala 
            20                  25                  30          


Ile Trp Gly Tyr Ser His Lys Asp Glu Ala Cys Pro Trp Ala Val Ser 
        35                  40                  45              


Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
    50                  55                  60                  


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
65                  70                  75                  80  


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
                85                  90                  95      


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
            100                 105                 110         


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
        115                 120                 125             


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
    130                 135                 140                 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
145                 150                 155                 160 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                165                 170                 175     


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
            180                 185                 190         


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
        195                 200                 205             


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
    210                 215                 220                 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
225                 230                 235                 240 


Pro Ser Pro Arg Ser Glu 
                245     


<210> 251
<211> 963
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 251
atgggttgct gtttctccaa gaccggctcg agcggcagcc aggacaccga ggtggatatg       60

aaggaggtgg agctgaatga gttagagccc gagaagcagc cgatgaacgc ggcgtctggg      120

gcggccatgt ccctggcggg agccgagaag aatggtctgg tgaagatcaa ggtggcggaa      180

gacgaggcgg aggcggcagc cgcggctaag ttcacgggcc tgtccaagga ggagctgctg      240

aaggtggcag gcagccccgg ctgggtacgc acccgctggg cactgctgct gctcttctgg      300

ctcggctggc tcggcatgct tgctggtgcc gtggtcataa tcgtggcctg cccctgggcc      360

gtgtccgggg ctcgcgcctc gcccggctcc gcggccagcc cgagactccg cgagggtccc      420

gagctttcgc ccgacgatcc cgccggcctc ttggacctgc ggcagggcat gtttgcgcag      480

ctggtggccc aaaatgttct gctgatcgat gggcccctga gctggtacag tgacccaggc      540

ctggcaggcg tgtccctgac ggggggcctg agctacaaag aggacacgaa ggagctggtg      600

gtggccaagg ctggagtcta ctatgtcttc tttcaactag agctgcggcg cgtggtggcc      660

ggcgagggct caggctccgt ttcacttgcg ctgcacctgc agccactgcg ctctgctgct      720

ggggccgccg ccctggcttt gaccgtggac ctgccacccg cctcctccga ggctcggaac      780

tcggccttcg gtttccaggg ccgcttgctg cacctgagtg ccggccagcg cctgggcgtc      840

catcttcaca ctgaggccag ggcacgccat gcctggcagc ttacccaggg cgccacagtc      900

ttgggactct tccgggtgac ccccgaaatc ccagccggac tcccttcacc gaggtcggaa      960

taa                                                                    963


<210> 252
<211> 320
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 252
Met Gly Cys Cys Phe Ser Lys Thr Gly Ser Ser Gly Ser Gln Asp Thr 
1               5                   10                  15      


Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu Leu Glu Pro Glu Lys 
            20                  25                  30          


Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met Ser Leu Ala Gly Ala 
        35                  40                  45              


Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala Glu Asp Glu Ala Glu 
    50                  55                  60                  


Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu 
65                  70                  75                  80  


Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr Arg Trp Ala Leu Leu 
                85                  90                  95      


Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu Ala Gly Ala Val Val 
            100                 105                 110         


Ile Ile Val Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
        115                 120                 125             


Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
    130                 135                 140                 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
145                 150                 155                 160 


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                165                 170                 175     


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
            180                 185                 190         


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
        195                 200                 205             


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
    210                 215                 220                 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
225                 230                 235                 240 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
                245                 250                 255     


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
            260                 265                 270         


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
        275                 280                 285             


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
    290                 295                 300                 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
305                 310                 315                 320 


<210> 253
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 253
atgggttgct gtttctccaa gaccggctcg agcggctggg ccctggtcgc ggggctgctg       60

ctgctgctgc tgctcgctgc cgcctgcgcc gtcttcctcg cctgcccctg ggccgtgtcc      120

ggggctcgcg cctcgcccgg ctccgcggcc agcccgagac tccgcgaggg tcccgagctt      180

tcgcccgacg atcccgccgg cctcttggac ctgcggcagg gcatgtttgc gcagctggtg      240

gcccaaaatg ttctgctgat cgatgggccc ctgagctggt acagtgaccc aggcctggca      300

ggcgtgtccc tgacgggggg cctgagctac aaagaggaca cgaaggagct ggtggtggcc      360

aaggctggag tctactatgt cttctttcaa ctagagctgc ggcgcgtggt ggccggcgag      420

ggctcaggct ccgtttcact tgcgctgcac ctgcagccac tgcgctctgc tgctggggcc      480

gccgccctgg ctttgaccgt ggacctgcca cccgcctcct ccgaggctcg gaactcggcc      540

ttcggtttcc agggccgctt gctgcacctg agtgccggcc agcgcctggg cgtccatctt      600

cacactgagg ccagggcacg ccatgcctgg cagcttaccc agggcgccac agtcttggga      660

ctcttccggg tgacccccga aatcccagcc ggactccctt caccgaggtc ggaataa         717


<210> 254
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 254
Met Gly Cys Cys Phe Ser Lys Thr Gly Ser Ser Gly Trp Ala Leu Val 
1               5                   10                  15      


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
            20                  25                  30          


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
        35                  40                  45              


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
    50                  55                  60                  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
65                  70                  75                  80  


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
                85                  90                  95      


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
            100                 105                 110         


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
        115                 120                 125             


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
    130                 135                 140                 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                165                 170                 175     


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
            180                 185                 190         


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
        195                 200                 205             


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
    210                 215                 220                 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
225                 230                 235             


<210> 255
<211> 798
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 255
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tgggctcgag cggcccaaat aaaggaagtg gaaccacttc aggtactacc      720

cgtcttctat ctgggcacac gtgtttcacg ttgacaggtt tgcttgggac gctagtaacc      780

atgggcttgc tgacttag                                                    798


<210> 256
<211> 265
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 256
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Gly Ser Ser Gly Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr 
225                 230                 235                 240 


Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly 
                245                 250                 255     


Thr Leu Val Thr Met Gly Leu Leu Thr 
            260                 265 


<210> 257
<211> 834
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 257
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc aggtaatatt ctgaatgtgt ccattaaaat atgtctaaca      720

ctgtccccta gcaccttcta cacaggagtc tatattctga tcggagccgg cgccctcatg      780

atgctggtgg gcttcctggg ctgctgcggg gctgtgcagg agtcccagtg ctag            834


<210> 258
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 258
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
                245                 250                 255     


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
            260                 265                 270         


Gln Glu Ser Gln Cys 
        275         


<210> 259
<211> 876
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 259
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc aggtaatatt ctgaatgtgt ccattaaaat atgtctaaca      720

ctgtccccta gcaccttcta cacaggagtc tatattctga tcggagccgg cgccctcatg      780

atgctggtgg gcttcctggg ctgctgcggg gctgtgcagg agtcccagtg caaaaagaag      840

aaaaagaagt caaagacaaa gtgtgtaatt atgtaa                                876


<210> 260
<211> 291
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 260
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
                245                 250                 255     


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
            260                 265                 270         


Gln Glu Ser Gln Cys Lys Lys Lys Lys Lys Lys Ser Lys Thr Lys Cys 
        275                 280                 285             


Val Ile Met 
    290     


<210> 261
<211> 837
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 261
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc aggtaatatt ctgaatgtgt ccattaaaat atgtctaaca      720

ctgtccccta gcaccatcgg cgcagtgggc atcggcattg ccgtggtcat gatatttggc      780

atgatcttca gtatgatctt gtgctgtgct atccgcagga accgcgagat ggtctag         837


<210> 262
<211> 278
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 262
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val 
                245                 250                 255     


Met Ile Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg 
            260                 265                 270         


Arg Asn Arg Glu Met Val 
        275             


<210> 263
<211> 843
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 263
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc aggtaatatt ctgaatgtgt ccattaaaat atgtctaaca      720

ctgtccccta gcaccctgta cctcatcggc attgctgcca tcgtggtcgc tgtgatcatg      780

atcttcgaga tgatcctgag catggtgctg tgctgtggca tccggaacag ctccgtgtac      840

tga                                                                    843


<210> 264
<211> 280
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 264
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr Leu Tyr Leu Ile Gly Ile Ala Ala Ile Val Val 
                245                 250                 255     


Ala Val Ile Met Ile Phe Glu Met Ile Leu Ser Met Val Leu Cys Cys 
            260                 265                 270         


Gly Ile Arg Asn Ser Ser Val Tyr 
        275                 280 


<210> 265
<211> 1503
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 265
atggagaggc tggtgatcag gatgcccttc tctcatctgt ctacctacag cctggtttgg       60

gtcatggcag cagtggtgct gtgcacagca caagtgcaag tggtgaccca ggatgaaaga      120

gagcagctgt acacacctgc ttccttaaaa tgctctctgc aaaatgccca ggaagccctc      180

attgtgacat ggcagaaaaa gaaagctgta agcccagaaa acatggtcac cttcagcgag      240

aaccatgggg tggtgatcca gcctgcctat aaggacaaga taaacattac ccagctggga      300

ctccaaaact caaccatcac cttctggaat atcaccctgg aggatgaagg gtgttacatg      360

tgtctcttca atacctttgg ttttgggaag atctcaggaa cggcctgcct caccgtctat      420

gtacagccca tagtatccct tcactacaaa ttctctgaag accacctaaa tatcacttgc      480

tctgccactg cccgcccagc ccccatggtc ttctggaagg tccctcggtc agggattgaa      540

aatagtacag tgactctgtc tcacccaaat gggaccacgt ctgttaccag catcctccat      600

atcaaagacc ctaagaatca ggtggggaag gaggtgatct gccaggtgct gcacctgggg      660

actgtgaccg actttaagca aaccgtcaac aaaggcatcg atgacaaaac tcacacatgc      720

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcacg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaaatcgatc caaataaagg aagtggaacc acttcaggta ctacccgtct tctatctggg     1440

cacacgtgtt tcacgttgac aggtttgctt gggacgctag taaccatggg cttgctgact     1500

tag                                                                   1503


<210> 266
<211> 500
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 266
Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Ile Asp Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Asp Pro 
    450                 455                 460                 


Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly 
465                 470                 475                 480 


His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met 
                485                 490                 495     


Gly Leu Leu Thr 
            500 


<210> 267
<211> 1050
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 267
atggcaaagg tgttcagttt catccttgtt accaccgctc tgacaatggg cagggaaatt       60

tcggcgctcg aggactgtgc ccaggagcag atgcggctca gagcccaggt gcgcctgctt      120

gagacccggg tcaaacagca acaggtcaag atcaagcagc ttttgcagga gaatgaagtc      180

cagttccttg ataaaggaga tgagaatact gtcattgatc ttggaagcaa gaggcagtat      240

gcagattgtt cagagatttt caatgatggg tataagctca gtggatttta caaaatcaaa      300

cctctccaga gcccagcaga attttctgtt tattgtgaca tgtccgatgg aggaggatgg      360

actgtaattc agagacgatc tgatggcagt gaaaacttta acagaggatg gaaagactat      420

gaaaatggct ttggaaattt tgtccaaaaa catggtgaat attggctggg caataaaaat      480

cttcacttct tgaccactca agaagactac actttaaaaa tcgaccttgc agattttgaa      540

aaaaatagcc gttatgcaca atataagaat ttcaaagttg gagatgaaaa gaatttctac      600

gagttgaata ttggggaata ttctggaaca gctggagatt cccttgcggg gaattttcat      660

cctgaggtgc agtggtgggc tagtcaccaa agaatgaaat tcagcacgtg ggacagagat      720

catgacaact atgaagggaa ctgcgcagaa gaagatcagt ctggctggtg gtttaacagg      780

tgtcactctg caaacctgaa tggtgtatac tacagcggcc cctacacggc taaaacagac      840

aatgggattg tctggtacac ctggcatggg tggtggtatt ctctgaaatc tgtggttatg      900

aaaattaggc caaatgattt tattccaaat gtaattccaa ataaaggaag tggaaccact      960

tcaggtacta cccgtcttct atctgggcac acgtgtttca cgttgacagg tttgcttggg     1020

acgctagtaa ccatgggctt gctgacttag                                      1050


<210> 268
<211> 349
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 268
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile Pro Asn Lys Gly Ser Gly Thr Thr 
305                 310                 315                 320 


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
                325                 330                 335     


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            340                 345                 


<210> 269
<211> 1872
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 269
atggccttca gcggttccca ggctccctac ctgagtccag ctgtcccctt ttctgggact       60

attcaaggag gtctccagga cggacttcag atcactgtca atgggaccgt tctcagctcc      120

agtggaacca ggtttgctgt gaactttcag actggcttca gtggaaatga cattgccttc      180

cacttcaacc ctcggtttga agatggaggg tacgtggtgt gcaacacgag gcagaacgga      240

agctgggggc ccgaggagag gaagacacac atgcctttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggat cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagaacccc cgcacagtcc ctgttcagcc tgccttctcc      480

acggtgccgt tctcccagcc tgtctgtttc ccacccaggc ccagggggcg cagacaaaaa      540

cctcccggcg tgtggcctgc caacccggct cccattaccc agacagtcat ccacacagtg      600

cagagcgccc ctggacagat gttctctact cccgccatcc cacctatgat gtacccccac      660

cccgcctatc cgatgccttt catcaccacc attctgggag ggctgtaccc atccaagtcc      720

atcctcctgt caggcactgt cctgcccagt gctcagaggt tccacatcaa cctgtgctct      780

gggaaccaca tcgccttcca cctgaacccc cgttttgatg agaatgctgt ggtccgcaac      840

acccagatcg acaactcctg ggggtctgag gagcgaagtc tgccccgaaa aatgcccttc      900

gtccgtggcc agagcttctc agtgtggatc ttgtgtgaag ctcactgcct caaggtggcc      960

gtggatggtc agcacctgtt tgaatactac catcgcctga ggaacctgcc caccatcaac     1020

agactggaag tggggggcga catccagctg acccatgtgc agacaatcga tgacaaaact     1080

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc     1140

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     1200

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1260

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1320

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     1380

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1440

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1500

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1560

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1620

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1680

tcatgctccg tgatgcacga ggctctgcac aaccactaca cgcagaagag cctctccctg     1740

tctccgggta aaatcgatcc aaataaagga agtggaacca cttcaggtac tacccgtctt     1800

ctatctgggc acacgtgttt cacgttgaca ggtttgcttg ggacgctagt aaccatgggc     1860

ttgctgactt ag                                                         1872


<210> 270
<211> 623
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 270
Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr Ile Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    450                 455                 460                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                485                 490                 495     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    530                 535                 540                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     


Ser Leu Ser Leu Ser Pro Gly Lys Ile Asp Pro Asn Lys Gly Ser Gly 
            580                 585                 590         


Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr 
        595                 600                 605             


Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    610                 615                 620             


<210> 271
<211> 810
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 271
atggagaggc tggtgatcag gatgcccttc tctcatctgt ctacctacag cctggtttgg       60

gtcatggcag cagtggtgct gtgcacagca caagtgcaag tggtgaccca ggatgaaaga      120

gagcagctgt acacacctgc ttccttaaaa tgctctctgc aaaatgccca ggaagccctc      180

attgtgacat ggcagaaaaa gaaagctgta agcccagaaa acatggtcac cttcagcgag      240

aaccatgggg tggtgatcca gcctgcctat aaggacaaga taaacattac ccagctggga      300

ctccaaaact caaccatcac cttctggaat atcaccctgg aggatgaagg gtgttacatg      360

tgtctcttca atacctttgg ttttgggaag atctcaggaa cggcctgcct caccgtctat      420

gtacagccca tagtatccct tcactacaaa ttctctgaag accacctaaa tatcacttgc      480

tctgccactg cccgcccagc ccccatggtc ttctggaagg tccctcggtc agggattgaa      540

aatagtacag tgactctgtc tcacccaaat gggaccacgt ctgttaccag catcctccat      600

atcaaagacc ctaagaatca ggtggggaag gaggtgatct gccaggtgct gcacctgggg      660

actgtgaccg actttaagca aaccgtcaac aaaggcccaa ataaaggaag tggaaccact      720

tcaggtacta cccgtcttct atctgggcac acgtgtttca cgttgacagg tttgcttggg      780

acgctagtaa ccatgggctt gctgacttag                                       810


<210> 272
<211> 269
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 272
Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Pro Asn Lys Gly Ser Gly Thr Thr 
225                 230                 235                 240 


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
                245                 250                 255     


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            260                 265                 


<210> 273
<211> 1179
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 273
atggccttca gcggttccca ggctccctac ctgagtccag ctgtcccctt ttctgggact       60

attcaaggag gtctccagga cggacttcag atcactgtca atgggaccgt tctcagctcc      120

agtggaacca ggtttgctgt gaactttcag actggcttca gtggaaatga cattgccttc      180

cacttcaacc ctcggtttga agatggaggg tacgtggtgt gcaacacgag gcagaacgga      240

agctgggggc ccgaggagag gaagacacac atgcctttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggat cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagaacccc cgcacagtcc ctgttcagcc tgccttctcc      480

acggtgccgt tctcccagcc tgtctgtttc ccacccaggc ccagggggcg cagacaaaaa      540

cctcccggcg tgtggcctgc caacccggct cccattaccc agacagtcat ccacacagtg      600

cagagcgccc ctggacagat gttctctact cccgccatcc cacctatgat gtacccccac      660

cccgcctatc cgatgccttt catcaccacc attctgggag ggctgtaccc atccaagtcc      720

atcctcctgt caggcactgt cctgcccagt gctcagaggt tccacatcaa cctgtgctct      780

gggaaccaca tcgccttcca cctgaacccc cgttttgatg agaatgctgt ggtccgcaac      840

acccagatcg acaactcctg ggggtctgag gagcgaagtc tgccccgaaa aatgcccttc      900

gtccgtggcc agagcttctc agtgtggatc ttgtgtgaag ctcactgcct caaggtggcc      960

gtggatggtc agcacctgtt tgaatactac catcgcctga ggaacctgcc caccatcaac     1020

agactggaag tggggggcga catccagctg acccatgtgc agacaccaaa taaaggaagt     1080

ggaaccactt caggtactac ccgtcttcta tctgggcaca cgtgtttcac gttgacaggt     1140

ttgcttggga cgctagtaac catgggcttg ctgacttag                            1179


<210> 274
<211> 392
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 274
Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
        355                 360                 365             


Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr 
    370                 375                 380                 


Leu Val Thr Met Gly Leu Leu Thr 
385                 390         


<210> 275
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 275
atggagcctc ctggagactg ggggcctcct ccctggagat ccacccccaa aaccgacgtc       60

ttgaggctgg tgctgtatct caccttcctg ggagccccct gctacgcccc agctctgccg      120

tcctgcaagg aggacgagta cccagtgggc tccgagtgct gccccaagtg cagtccaggt      180

tatcgtgtga aggaggcctg cggggagctg acgggcacag tgtgtgaacc ctgccctcca      240

ggcacctaca ttgcccacct caatggccta agcaagtgtc tgcagtgcca aatgtgtgac      300

ccagccatgg gcctgcgcgc gagccggaac tgctccagga cagagaacgc cgtgtgtggc      360

tgcagcccag gccacttctg catcgtccag gacggggacc actgcgccgc gtgccgcgct      420

tacgccacct ccagcccggg ccagagggtg cagaagggag gcaccgagag tcaggacacc      480

ctgtgtcaga actgcccccc ggggaccttc tctcccaatg ggaccctgga ggaatgtcag      540

caccagacca agtgcagctg gctggtgacg aaggccggag ctgggaccag cagctcccac      600

tgggtaccaa ataaaggaag tggaaccact tcaggtacta cccgtcttct atctgggcac      660

acgtgtttca cgttgacagg tttgcttggg acgctagtaa ccatgggctt gctgacttag      720


<210> 276
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 276
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Pro Asn Lys Gly Ser Gly 
        195                 200                 205             


Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr 
    210                 215                 220                 


Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
225                 230                 235                 


<210> 277
<211> 774
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 277
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta       60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg      120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa      180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg      240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac      300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa      360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag      420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt      480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg      540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg      600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact      660

ccaaataaag gaagtggaac cacttcaggt actacccgtc ttctatctgg gcacacgtgt      720

ttcacgttga caggtttgct tgggacgcta gtaaccatgg gcttgctgac ttag            774


<210> 278
<211> 257
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 278
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Pro Asn Lys Gly 
    210                 215                 220                 


Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys 
225                 230                 235                 240 


Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu 
                245                 250                 255     


Thr 
    


<210> 279
<211> 951
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 279
atgatcatct taatttactt atttctcttg ctatgggaag acactcaagg atggggattc       60

aaggatggaa tttttcataa ctccatatgg cttgaacgag cagccggtgt gtaccacaga      120

gaagcacggt ctggcaaata caagctcacc tacgcagaag ctaaggcggt gtgtgaattt      180

gaaggcggcc atctcgcaac ttacaagcag ctagaggcag ccagaaaaat tggatttcat      240

gtctgtgctg ctggatggat ggctaagggc agagttggat accccattgt gaagccaggg      300

cccaactgtg gatttggaaa aactggcatt attgattatg gaatccgtct caataggagt      360

gaaagatggg atgcctattg ctacaaccca cacgcaaagg agtgtggtgg cgtctttaca      420

gatccaaagc aaatttttaa atctccaggc ttcccaaatg agtacgaaga taaccaaatc      480

tgctactggc acattagact caagtatggt cagcgtattc acctgagttt tttagatttt      540

gaccttgaag atgacccagg ttgcttggct gattatgttg aaatatatga cagttacgat      600

gatgtccatg gctttgtggg aagatactgt ggagatgagc ttccagatga catcatcagt      660

acaggaaatg tcatgacctt gaagtttcta agtgatgctt cagtgacagc tggaggtttc      720

caaatcaaat atgttgcaat ggatcctgta tccaaatcca gtcaaggaaa aaatacaagt      780

actacttcta ctggaaataa aaacttttta gctggaagat ttagccactt aatcgatcca      840

aataaaggaa gtggaaccac ttcaggtact acccgtcttc tatctgggca cacgtgtttc      900

acgttgacag gtttgcttgg gacgctagta accatgggct tgctgactta g               951


<210> 280
<211> 316
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 280
Met Ile Ile Leu Ile Tyr Leu Phe Leu Leu Leu Trp Glu Asp Thr Gln 
1               5                   10                  15      


Gly Trp Gly Phe Lys Asp Gly Ile Phe His Asn Ser Ile Trp Leu Glu 
            20                  25                  30          


Arg Ala Ala Gly Val Tyr His Arg Glu Ala Arg Ser Gly Lys Tyr Lys 
        35                  40                  45              


Leu Thr Tyr Ala Glu Ala Lys Ala Val Cys Glu Phe Glu Gly Gly His 
    50                  55                  60                  


Leu Ala Thr Tyr Lys Gln Leu Glu Ala Ala Arg Lys Ile Gly Phe His 
65                  70                  75                  80  


Val Cys Ala Ala Gly Trp Met Ala Lys Gly Arg Val Gly Tyr Pro Ile 
                85                  90                  95      


Val Lys Pro Gly Pro Asn Cys Gly Phe Gly Lys Thr Gly Ile Ile Asp 
            100                 105                 110         


Tyr Gly Ile Arg Leu Asn Arg Ser Glu Arg Trp Asp Ala Tyr Cys Tyr 
        115                 120                 125             


Asn Pro His Ala Lys Glu Cys Gly Gly Val Phe Thr Asp Pro Lys Gln 
    130                 135                 140                 


Ile Phe Lys Ser Pro Gly Phe Pro Asn Glu Tyr Glu Asp Asn Gln Ile 
145                 150                 155                 160 


Cys Tyr Trp His Ile Arg Leu Lys Tyr Gly Gln Arg Ile His Leu Ser 
                165                 170                 175     


Phe Leu Asp Phe Asp Leu Glu Asp Asp Pro Gly Cys Leu Ala Asp Tyr 
            180                 185                 190         


Val Glu Ile Tyr Asp Ser Tyr Asp Asp Val His Gly Phe Val Gly Arg 
        195                 200                 205             


Tyr Cys Gly Asp Glu Leu Pro Asp Asp Ile Ile Ser Thr Gly Asn Val 
    210                 215                 220                 


Met Thr Leu Lys Phe Leu Ser Asp Ala Ser Val Thr Ala Gly Gly Phe 
225                 230                 235                 240 


Gln Ile Lys Tyr Val Ala Met Asp Pro Val Ser Lys Ser Ser Gln Gly 
                245                 250                 255     


Lys Asn Thr Ser Thr Thr Ser Thr Gly Asn Lys Asn Phe Leu Ala Gly 
            260                 265                 270         


Arg Phe Ser His Leu Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser 
        275                 280                 285             


Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly 
    290                 295                 300                 


Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
305                 310                 315     


<210> 281
<211> 1413
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 281
atggagcctc ctggagactg ggggcctcct ccctggagat ccacccccaa aaccgacgtc       60

ttgaggctgg tgctgtatct caccttcctg ggagccccct gctacgcccc agctctgccg      120

tcctgcaagg aggacgagta cccagtgggc tccgagtgct gccccaagtg cagtccaggt      180

tatcgtgtga aggaggcctg cggggagctg acgggcacag tgtgtgaacc ctgccctcca      240

ggcacctaca ttgcccacct caatggccta agcaagtgtc tgcagtgcca aatgtgtgac      300

ccagccatgg gcctgcgcgc gagccggaac tgctccagga cagagaacgc cgtgtgtggc      360

tgcagcccag gccacttctg catcgtccag gacggggacc actgcgccgc gtgccgcgct      420

tacgccacct ccagcccggg ccagagggtg cagaagggag gcaccgagag tcaggacacc      480

ctgtgtcaga actgcccccc ggggaccttc tctcccaatg ggaccctgga ggaatgtcag      540

caccagacca agtgcagctg gctggtgacg aaggccggag ctgggaccag cagctcccac      600

tgggtaatcg atgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      660

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      720

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      780

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      840

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      900

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      960

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1020

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1080

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1140

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1200

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcacg aggctctgca caaccactac     1260

acgcagaaga gcctctccct gtctccgggt aaaatcgatc caaataaagg aagtggaacc     1320

acttcaggta ctacccgtct tctatctggg cacacgtgtt tcacgttgac aggtttgctt     1380

gggacgctag taaccatggg cttgctgact tag                                  1413


<210> 282
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 282
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Ile Asp Asp Lys Thr His 
        195                 200                 205             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    210                 215                 220                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
225                 230                 235                 240 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                245                 250                 255     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            260                 265                 270         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        275                 280                 285             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    290                 295                 300                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                325                 330                 335     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            340                 345                 350         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        355                 360                 365             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    370                 375                 380                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
385                 390                 395                 400 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                405                 410                 415     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile 
            420                 425                 430         


Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu 
        435                 440                 445             


Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val 
    450                 455                 460                 


Thr Met Gly Leu Leu Thr 
465                 470 


<210> 283
<211> 1611
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 283
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggccaaat      720

aaaggaagtg gaaccacttc aggtactacc cgtcttctat ctgggcacac gtgtttcacg      780

ttgacaggtt tgcttgggac gctagtaacc atgggcttgc tgactggaag cggagctact      840

aacttcagcc tgctgaagca ggctggcgac gtggaggaga accctggacc tatggagcct      900

cctggagact gggggcctcc tccctggaga tccaccccca aaaccgacgt cttgaggctg      960

gtgctgtatc tcaccttcct gggagccccc tgctacgccc cagctctgcc gtcctgcaag     1020

gaggacgagt acccagtggg ctccgagtgc tgccccaagt gcagtccagg ttatcgtgtg     1080

aaggaggcct gcggggagct gacgggcaca gtgtgtgaac cctgccctcc aggcacctac     1140

attgcccacc tcaatggcct aagcaagtgt ctgcagtgcc aaatgtgtga cccagccatg     1200

ggcctgcgcg cgagccggaa ctgctccagg acagagaacg ccgtgtgtgg ctgcagccca     1260

ggccacttct gcatcgtcca ggacggggac cactgcgccg cgtgccgcgc ttacgccacc     1320

tccagcccgg gccagagggt gcagaaggga ggcaccgaga gtcaggacac cctgtgtcag     1380

aactgccccc cggggacctt ctctcccaat gggaccctgg aggaatgtca gcaccagacc     1440

aagtgcagct ggctggtgac gaaggccgga gctgggacca gcagctccca ctgggtacca     1500

aataaaggaa gtggaaccac ttcaggtact acccgtcttc tatctgggca cacgtgtttc     1560

acgttgacag gtttgcttgg gacgctagta accatgggct tgctgactta g              1611


<210> 284
<211> 536
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 284
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Pro Asn 
225                 230                 235                 240 


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
                245                 250                 255     


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
            260                 265                 270         


Leu Leu Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Pro Pro Gly Asp Trp 
    290                 295                 300                 


Gly Pro Pro Pro Trp Arg Ser Thr Pro Lys Thr Asp Val Leu Arg Leu 
305                 310                 315                 320 


Val Leu Tyr Leu Thr Phe Leu Gly Ala Pro Cys Tyr Ala Pro Ala Leu 
                325                 330                 335     


Pro Ser Cys Lys Glu Asp Glu Tyr Pro Val Gly Ser Glu Cys Cys Pro 
            340                 345                 350         


Lys Cys Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu Thr 
        355                 360                 365             


Gly Thr Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His Leu 
    370                 375                 380                 


Asn Gly Leu Ser Lys Cys Leu Gln Cys Gln Met Cys Asp Pro Ala Met 
385                 390                 395                 400 


Gly Leu Arg Ala Ser Arg Asn Cys Ser Arg Thr Glu Asn Ala Val Cys 
                405                 410                 415     


Gly Cys Ser Pro Gly His Phe Cys Ile Val Gln Asp Gly Asp His Cys 
            420                 425                 430         


Ala Ala Cys Arg Ala Tyr Ala Thr Ser Ser Pro Gly Gln Arg Val Gln 
        435                 440                 445             


Lys Gly Gly Thr Glu Ser Gln Asp Thr Leu Cys Gln Asn Cys Pro Pro 
    450                 455                 460                 


Gly Thr Phe Ser Pro Asn Gly Thr Leu Glu Glu Cys Gln His Gln Thr 
465                 470                 475                 480 


Lys Cys Ser Trp Leu Val Thr Lys Ala Gly Ala Gly Thr Ser Ser Ser 
                485                 490                 495     


His Trp Val Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
            500                 505                 510         


Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr 
        515                 520                 525             


Leu Val Thr Met Gly Leu Leu Thr 
    530                 535     


<210> 285
<211> 1289
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 285
atggcttgtc ttggactccg gaggtacaaa gctcaactgc agctgccttc taggacttgg       60

ccttttgtag ccctgctcac tcttcttttc atcccagtct tctctgaagc catacaggtg      120

acccaacctt cagtggtgtt ggctagcagc catggtgtcg ccagctttcc atgtgaatat      180

tcaccatcac acaacactga tgaggtccgg gtgactgtgc tgcggcagac aaatgaccaa      240

atgactgagg tctgtgccac gacattcaca gagaagaata cagtgggctt cctagattac      300

cccttctgca gtggtacctt taatgaaagc agagtgaacc tcaccatcca aggactgaga      360

gctgttgaca cgggactgta cctctgcaag gtggaactca tgtacccacc gccatacttt      420

gtgggcatgg gcaacgggac gcagatttat gtcattgatc cagaaccatg cccggattct      480

gaatcgatga caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac      540

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg      600

aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt      660

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca      720

gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg aatggcaagg      780

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca      840

aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggaggaga      900

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg      960

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc     1020

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc     1080

agcaggggaa cgtcttctca tgctccgtga tgcacgaggc tctgcacaac cactacacgc     1140

agaagagcct ctccctgtct ccgggtaaaa tcgatccaaa taaaggaagt ggaaccactt     1200

caggtactac ccgtcttcta tctgggcaca cgtgtttcac gttgacaggt ttgcttggga     1260

cgctagtaac catgggcttg ctgacttag                                       1289


<210> 286
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 286
Met Ala Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              


Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  


Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      


Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Ile Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                165                 170                 175     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            180                 185                 190         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        195                 200                 205             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    210                 215                 220                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
225                 230                 235                 240 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                245                 250                 255     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            260                 265                 270         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        275                 280                 285             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    290                 295                 300                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
305                 310                 315                 320 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                325                 330                 335     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            340                 345                 350         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        355                 360                 365             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    370                 375                 380                 


Ser Leu Ser Pro Gly Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr 
385                 390                 395                 400 


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
                405                 410                 415     


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            420                 425                 


<210> 287
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 287
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactatcgat      720

gtcgagccac tgggcatgga gaatgggaac attgccaact cacagatcgc cgcctcatct      780

gtgcgtgtga ccttcttggg tttgcagcat tgggtcccgg agctggcccg cctgaaccgc      840

gcaggcatgg tcaatgcctg gacacccagc agcaatgacg ataacccctg gatccaggtg      900

aacctgctgc ggaggatgtg ggtaacaggt gtggtgacgc agggtgccag ccgcttggcc      960

agtcatgagt acctgaaggc cttcaaggtg gcctacagcc ttaatggaca cgaattcgat     1020

ttcatccatg atgttaataa aaaacacaag gagtttgtgg gtaactggaa caaaaacgcg     1080

gtgcatgtca acctgtttga gacccctgtg gaggctcagt acgtgagatt gtaccccacg     1140

agctgccaca cggcctgcac tctgcgcttt gagctactgg gctgtgagct gaacggatgc     1200

gccaatcccc tgggcctgaa gaataacagc atccctgaca agcagatcac ggcctccagc     1260

agctacaaga cctggggctt gcatctcttc agctggaacc cctcctatgc acggctggac     1320

aagcagggca acttcaacgc ctgggttgcg gggagctacg gtaacgatca gtggctgcag     1380

atcttccctg gcaactggga caaccactcc cacaagaaga acttgtttga gacgcccatc     1440

ctggctcgct atgtgcgcat cctgcctgta gcctggcaca accgcatcgc cctgcgcctg     1500

gagctgctgg gctgttag                                                   1518


<210> 288
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 288
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Ile Asp 
225                 230                 235                 240 


Val Glu Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile 
                245                 250                 255     


Ala Ala Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val 
            260                 265                 270         


Pro Glu Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr 
        275                 280                 285             


Pro Ser Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg 
    290                 295                 300                 


Arg Met Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala 
305                 310                 315                 320 


Ser His Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly 
                325                 330                 335     


His Glu Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe 
            340                 345                 350         


Val Gly Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr 
        355                 360                 365             


Pro Val Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr 
    370                 375                 380                 


Ala Cys Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys 
385                 390                 395                 400 


Ala Asn Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile 
                405                 410                 415     


Thr Ala Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp 
            420                 425                 430         


Asn Pro Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp 
        435                 440                 445             


Val Ala Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Ile Phe Pro Gly 
    450                 455                 460                 


Asn Trp Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile 
465                 470                 475                 480 


Leu Ala Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile 
                485                 490                 495     


Ala Leu Arg Leu Glu Leu Leu Gly Cys 
            500                 505 


<210> 289
<211> 1521
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 289
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactatcgat      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa aatcgatcca aataaaggaa gtggaaccac ttcaggtact     1440

acccgtcttc tatctgggca cacgtgtttc acgttgacag gtttgcttgg gacgctagta     1500

accatgggct tgctgactta g                                               1521


<210> 290
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 290
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Ile Asp 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr 
465                 470                 475                 480 


Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu 
                485                 490                 495     


Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            500                 505     


<210> 291
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 291
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactccaaat      720

aaaggaagtg gaaccacttc aggtactacc cgtcttctat ctgggcacac gtgtttcacg      780

ttgacaggtt tgcttgggac gctagtaacc atgggcttgc tgacttag                   828


<210> 292
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 292
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Pro Asn 
225                 230                 235                 240 


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
                245                 250                 255     


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
            260                 265                 270         


Leu Leu Thr 
        275 


<210> 293
<211> 1464
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 293
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta       60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg      120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag      180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg      240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac      300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa      360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag      420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt      480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg      540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag      600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg      660

atcgatgtcg agccactggg catggagaat gggaacattg ccaactcaca gatcgccgcc      720

tcatctgtgc gtgtgacctt cttgggtttg cagcattggg tcccggagct ggcccgcctg      780

aaccgcgcag gcatggtcaa tgcctggaca cccagcagca atgacgataa cccctggatc      840

caggtgaacc tgctgcggag gatgtgggta acaggtgtgg tgacgcaggg tgccagccgc      900

ttggccagtc atgagtacct gaaggccttc aaggtggcct acagccttaa tggacacgaa      960

ttcgatttca tccatgatgt taataaaaaa cacaaggagt ttgtgggtaa ctggaacaaa     1020

aacgcggtgc atgtcaacct gtttgagacc cctgtggagg ctcagtacgt gagattgtac     1080

cccacgagct gccacacggc ctgcactctg cgctttgagc tactgggctg tgagctgaac     1140

ggatgcgcca atcccctggg cctgaagaat aacagcatcc ctgacaagca gatcacggcc     1200

tccagcagct acaagacctg gggcttgcat ctcttcagct ggaacccctc ctatgcacgg     1260

ctggacaagc agggcaactt caacgcctgg gttgcgggga gctacggtaa cgatcagtgg     1320

ctgcagatct tccctggcaa ctgggacaac cactcccaca agaagaactt gtttgagacg     1380

cccatcctgg ctcgctatgt gcgcatcctg cctgtagcct ggcacaaccg catcgccctg     1440

cgcctggagc tgctgggctg ttag                                            1464


<210> 294
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 294
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Ile Asp Val Glu 
    210                 215                 220                 


Pro Leu Gly Met Glu Asn Gly Asn Ile Ala Asn Ser Gln Ile Ala Ala 
225                 230                 235                 240 


Ser Ser Val Arg Val Thr Phe Leu Gly Leu Gln His Trp Val Pro Glu 
                245                 250                 255     


Leu Ala Arg Leu Asn Arg Ala Gly Met Val Asn Ala Trp Thr Pro Ser 
            260                 265                 270         


Ser Asn Asp Asp Asn Pro Trp Ile Gln Val Asn Leu Leu Arg Arg Met 
        275                 280                 285             


Trp Val Thr Gly Val Val Thr Gln Gly Ala Ser Arg Leu Ala Ser His 
    290                 295                 300                 


Glu Tyr Leu Lys Ala Phe Lys Val Ala Tyr Ser Leu Asn Gly His Glu 
305                 310                 315                 320 


Phe Asp Phe Ile His Asp Val Asn Lys Lys His Lys Glu Phe Val Gly 
                325                 330                 335     


Asn Trp Asn Lys Asn Ala Val His Val Asn Leu Phe Glu Thr Pro Val 
            340                 345                 350         


Glu Ala Gln Tyr Val Arg Leu Tyr Pro Thr Ser Cys His Thr Ala Cys 
        355                 360                 365             


Thr Leu Arg Phe Glu Leu Leu Gly Cys Glu Leu Asn Gly Cys Ala Asn 
    370                 375                 380                 


Pro Leu Gly Leu Lys Asn Asn Ser Ile Pro Asp Lys Gln Ile Thr Ala 
385                 390                 395                 400 


Ser Ser Ser Tyr Lys Thr Trp Gly Leu His Leu Phe Ser Trp Asn Pro 
                405                 410                 415     


Ser Tyr Ala Arg Leu Asp Lys Gln Gly Asn Phe Asn Ala Trp Val Ala 
            420                 425                 430         


Gly Ser Tyr Gly Asn Asp Gln Trp Leu Gln Ile Phe Pro Gly Asn Trp 
        435                 440                 445             


Asp Asn His Ser His Lys Lys Asn Leu Phe Glu Thr Pro Ile Leu Ala 
    450                 455                 460                 


Arg Tyr Val Arg Ile Leu Pro Val Ala Trp His Asn Arg Ile Ala Leu 
465                 470                 475                 480 


Arg Leu Glu Leu Leu Gly Cys 
                485         


<210> 295
<211> 1467
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 295
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta       60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg      120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag      180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg      240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac      300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa      360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag      420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt      480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg      540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag      600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg      660

atcgatgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg cacgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaaatc gatccaaata aaggaagtgg aaccacttca     1380

ggtactaccc gtcttctatc tgggcacacg tgtttcacgt tgacaggttt gcttgggacg     1440

ctagtaacca tgggcttgct gacttag                                         1467


<210> 296
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 296
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Ile Asp Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Ile Asp Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg 
    450                 455                 460                 


Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr 
465                 470                 475                 480 


Leu Val Thr Met Gly Leu Leu Thr 
                485             


<210> 297
<211> 1494
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 297
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactggttgt      720

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      780

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      840

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      900

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      960

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct     1020

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1080

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1140

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1200

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1260

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1320

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1380

ccaaataaag gaagtggaac cacttcaggt actacccgtc ttctatctgg gcacacgtgt     1440

ttcacgttga caggtttgct tgggacgcta gtaaccatgg gcttgctgac ttag           1494


<210> 298
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 298
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Pro Asn Lys Gly 
    450                 455                 460                 


Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys 
465                 470                 475                 480 


Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu 
                485                 490                 495     


Thr 
    


<210> 299
<211> 774
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 299
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta       60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg      120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag      180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg      240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac      300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa      360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag      420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt      480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg      540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag      600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg      660

ccaaataaag gaagtggaac cacttcaggt actacccgtc ttctatctgg gcacacgtgt      720

ttcacgttga caggtttgct tgggacgcta gtaaccatgg gcttgctgac ttag            774


<210> 300
<211> 257
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 300
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Pro Asn Lys Gly 
    210                 215                 220                 


Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys 
225                 230                 235                 240 


Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu 
                245                 250                 255     


Thr 
    


<210> 301
<211> 1623
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 301
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactccaaat      720

aaaggaagtg gaaccacttc aggtactacc cgtcttctat ctgggcacac gtgtttcacg      780

ttgacaggtt tgcttgggac gctagtaacc atgggcttgc tgactggaag cggagctact      840

aacttcagcc tgctgaagca ggctggcgac gtggaggaga accctggacc tatggaacct      900

ctcccaggat gggggtcggc accctggagc caggccccta cagacaacac cttcaggctg      960

gtgccttgtg tcttcctttt gaacttgctg cagcgcatct ctgcccagcc ctcatgcaga     1020

caggaggagt tccttgtggg agacgagtgc tgccccatgt gcaacccagg ttaccatgtg     1080

aagcaggtct gcagtgagca tacaggcaca gtgtgtgccc cctgtccccc acagacatat     1140

accgcccatg caaatggcct gagcaagtgt ctgccctgcg gagtctgtga tccagacatg     1200

ggcctgctga cctggcagga gtgctccagc tggaaggaca ctgtgtgcag atgcatccca     1260

ggctacttct gtgagaacca ggatgggagc cactgttcca catgcttgca gcacaccacc     1320

tgccctccag ggcagagggt agagaagaga gggactcacg accaggacac tgtatgtgct     1380

gactgcctaa cagggacctt ctcacttgga gggactcagg aggaatgcct gccctggacc     1440

aactgcagtg catttcaaca ggaagtaaga cgtgggacca acagcacaga caccacctgc     1500

tcctcccagc caaataaagg aagtggaacc acttcaggta ctacccgtct tctatctggg     1560

cacacgtgtt tcacgttgac aggtttgctt gggacgctag taaccatggg cttgctgact     1620

tag                                                                   1623


<210> 302
<211> 540
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 302
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Pro Asn 
225                 230                 235                 240 


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
                245                 250                 255     


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
            260                 265                 270         


Leu Leu Thr Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu Pro Leu Pro Gly Trp 
    290                 295                 300                 


Gly Ser Ala Pro Trp Ser Gln Ala Pro Thr Asp Asn Thr Phe Arg Leu 
305                 310                 315                 320 


Val Pro Cys Val Phe Leu Leu Asn Leu Leu Gln Arg Ile Ser Ala Gln 
                325                 330                 335     


Pro Ser Cys Arg Gln Glu Glu Phe Leu Val Gly Asp Glu Cys Cys Pro 
            340                 345                 350         


Met Cys Asn Pro Gly Tyr His Val Lys Gln Val Cys Ser Glu His Thr 
        355                 360                 365             


Gly Thr Val Cys Ala Pro Cys Pro Pro Gln Thr Tyr Thr Ala His Ala 
    370                 375                 380                 


Asn Gly Leu Ser Lys Cys Leu Pro Cys Gly Val Cys Asp Pro Asp Met 
385                 390                 395                 400 


Gly Leu Leu Thr Trp Gln Glu Cys Ser Ser Trp Lys Asp Thr Val Cys 
                405                 410                 415     


Arg Cys Ile Pro Gly Tyr Phe Cys Glu Asn Gln Asp Gly Ser His Cys 
            420                 425                 430         


Ser Thr Cys Leu Gln His Thr Thr Cys Pro Pro Gly Gln Arg Val Glu 
        435                 440                 445             


Lys Arg Gly Thr His Asp Gln Asp Thr Val Cys Ala Asp Cys Leu Thr 
    450                 455                 460                 


Gly Thr Phe Ser Leu Gly Gly Thr Gln Glu Glu Cys Leu Pro Trp Thr 
465                 470                 475                 480 


Asn Cys Ser Ala Phe Gln Gln Glu Val Arg Arg Gly Thr Asn Ser Thr 
                485                 490                 495     


Asp Thr Thr Cys Ser Ser Gln Pro Asn Lys Gly Ser Gly Thr Thr Ser 
            500                 505                 510         


Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly 
        515                 520                 525             


Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    530                 535                 540 


<210> 303
<211> 1584
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 303
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggtgtgga      720

aatggaatgg tagaacaagg tgaagaatgt gattgtggct atagtgacca gtgtaaagat      780

gaatgctgct tcgatgcaaa tcaaccagag ggaagaaaat gcaaactgaa acctgggaaa      840

cagtgcagtc caagtcaagg tccttgttgt acagcacagt gtgcattcaa gtcaaagtct      900

gagaagtgtc gggatgattc agactgtgca agggaaggaa tatgtaatgg cttcacagct      960

ctctgcccag catctgaccc taaaccaaac ttcacagact gtaataggca tacacaagtg     1020

tgcattaatg ggcaatgtgc aggttctatc tgtgagaaat atggcttaga ggagtgtacg     1080

tgtgccagtt ctgatggcaa agatgataaa gaattatgcc atgtatgctg tatgaagaaa     1140

atggacccat caacttgtgc cagtacaggg tctgtgcagt ggagtaggca cttcagtggt     1200

cgaaccatca ccctgcaacc tggatcccct tgcaacgatt ttagaggtta ctgtgatgtt     1260

ttcatgcggt gcagattagt agatgctgat ggtcctctag ctaggcttaa aaaagcaatt     1320

tttagtccag agctctatga aaacattgct gaatggattg tggctcattg gtgggcagta     1380

ttacttatgg gaattgctct gatcatgcta atggctggat ttattaagat atgcagtgtt     1440

catactccaa gtagtaatcc aaagttgcct cctcctaaac cacttccagg cactttaaag     1500

aggaggagac ctccacagcc cattcagcaa ccccagcgtc agcggccccg agagagttat     1560

caaatgggac acatgagacg ctaa                                            1584


<210> 304
<211> 527
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 304
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Cys Gly 
225                 230                 235                 240 


Asn Gly Met Val Glu Gln Gly Glu Glu Cys Asp Cys Gly Tyr Ser Asp 
                245                 250                 255     


Gln Cys Lys Asp Glu Cys Cys Phe Asp Ala Asn Gln Pro Glu Gly Arg 
            260                 265                 270         


Lys Cys Lys Leu Lys Pro Gly Lys Gln Cys Ser Pro Ser Gln Gly Pro 
        275                 280                 285             


Cys Cys Thr Ala Gln Cys Ala Phe Lys Ser Lys Ser Glu Lys Cys Arg 
    290                 295                 300                 


Asp Asp Ser Asp Cys Ala Arg Glu Gly Ile Cys Asn Gly Phe Thr Ala 
305                 310                 315                 320 


Leu Cys Pro Ala Ser Asp Pro Lys Pro Asn Phe Thr Asp Cys Asn Arg 
                325                 330                 335     


His Thr Gln Val Cys Ile Asn Gly Gln Cys Ala Gly Ser Ile Cys Glu 
            340                 345                 350         


Lys Tyr Gly Leu Glu Glu Cys Thr Cys Ala Ser Ser Asp Gly Lys Asp 
        355                 360                 365             


Asp Lys Glu Leu Cys His Val Cys Cys Met Lys Lys Met Asp Pro Ser 
    370                 375                 380                 


Thr Cys Ala Ser Thr Gly Ser Val Gln Trp Ser Arg His Phe Ser Gly 
385                 390                 395                 400 


Arg Thr Ile Thr Leu Gln Pro Gly Ser Pro Cys Asn Asp Phe Arg Gly 
                405                 410                 415     


Tyr Cys Asp Val Phe Met Arg Cys Arg Leu Val Asp Ala Asp Gly Pro 
            420                 425                 430         


Leu Ala Arg Leu Lys Lys Ala Ile Phe Ser Pro Glu Leu Tyr Glu Asn 
        435                 440                 445             


Ile Ala Glu Trp Ile Val Ala His Trp Trp Ala Val Leu Leu Met Gly 
    450                 455                 460                 


Ile Ala Leu Ile Met Leu Met Ala Gly Phe Ile Lys Ile Cys Ser Val 
465                 470                 475                 480 


His Thr Pro Ser Ser Asn Pro Lys Leu Pro Pro Pro Lys Pro Leu Pro 
                485                 490                 495     


Gly Thr Leu Lys Arg Arg Arg Pro Pro Gln Pro Ile Gln Gln Pro Gln 
            500                 505                 510         


Arg Gln Arg Pro Arg Glu Ser Tyr Gln Met Gly His Met Arg Arg 
        515                 520                 525         


<210> 305
<211> 1497
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 305
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aagggagtcc      720

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gggtcctcac cgtcctgcac caggactggc tgaacggtaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggaggacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctccgggtaa attctacaca ggagtctata ttctgatcgg agccggcgcc     1440

ctcatgatgc tggtgggctt cctgggctgc tgcggggctg tgcaggagtc ccagtgc        1497


<210> 306
<211> 502
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 306
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Arg Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asp Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly Ala 
465                 470                 475                 480 


Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln Glu 
                485                 490                 495     


Ser Gln Cys Val Ile Met 
            500         


<210> 307
<211> 1542
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 307
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aagggagtcc      720

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gggtcctcac cgtcctgcac caggactggc tgaacggtaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggaggacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctccgggtaa attctacaca ggagtctata ttctgatcgg agccggcgcc     1440

ctcatgatgc tggtgggctt cctgggctgc tgcggggctg tgcaggagtc ccagtgcaaa     1500

aagaagaaaa agaagaagaa gacaaagtgt gtaattatgt aa                        1542


<210> 308
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 308
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Arg Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asp Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly Ala 
465                 470                 475                 480 


Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln Glu 
                485                 490                 495     


Ser Gln Cys Lys Lys Lys Lys Lys Lys Lys Lys Thr Lys Cys Val Ile 
            500                 505                 510         


Met 
    


<210> 309
<211> 1515
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 309
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggatcgat      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa aatcgatttc tacacaggag tctatattct gatcggagcc     1440

ggcgccctca tgatgctggt gggcttcctg ggctgctgcg gggctgtgca ggagtcccag     1500

tgcgtaatta tgtaa                                                      1515


<210> 310
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 310
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Ile Asp 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Ile Asp Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
465                 470                 475                 480 


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
                485                 490                 495     


Gln Glu Ser Gln Cys Val Ile Met 
            500                 


<210> 311
<211> 1548
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 311
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggatcgat      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa aatcgatttc tacacaggag tctatattct gatcggagcc     1440

ggcgccctca tgatgctggt gggcttcctg ggctgctgcg gggctgtgca ggagtcccag     1500

tgcaaaaaga agaaaaagaa gaagaagaca aagtgtgtaa ttatgtaa                  1548


<210> 312
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 312
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Ile Asp 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Ile Asp Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala 
465                 470                 475                 480 


Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val 
                485                 490                 495     


Gln Glu Ser Gln Cys Lys Lys Lys Lys Lys Lys Lys Lys Thr Lys Cys 
            500                 505                 510         


Val Ile Met 
        515 


<210> 313
<211> 1488
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 313
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactggttgt      720

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      780

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      840

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      900

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      960

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct     1020

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1080

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1140

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1200

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1260

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1320

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1380

ttctacacag gagtctatat tctgatcgga gccggcgccc tcatgatgct ggtgggcttc     1440

ctgggctgct gcggggctgt gcaggagtcc cagtgcgtaa ttatgtaa                  1488


<210> 314
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 314
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Phe Tyr Thr Gly 
    450                 455                 460                 


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
465                 470                 475                 480 


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Val Ile Met 
                485                 490                 495 


<210> 315
<211> 1521
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 315
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactggttgt      720

aagccttgca tatgtacagt cccagaagta tcatctgtct tcatcttccc cccaaagccc      780

aaggatgtgc tcaccattac tctgactcct aaggtcacgt gtgttgtggt agacatcagc      840

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      900

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      960

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct     1020

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1080

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1140

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1200

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1260

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1320

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1380

ttctacacag gagtctatat tctgatcgga gccggcgccc tcatgatgct ggtgggcttc     1440

ctgggctgct gcggggctgt gcaggagtcc cagtgcaaaa agaagaaaaa gaagaagaag     1500

acaaagtgtg taattatgta a                                               1521


<210> 316
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 316
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Phe Tyr Thr Gly 
    450                 455                 460                 


Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe 
465                 470                 475                 480 


Leu Gly Cys Cys Gly Ala Val Gln Glu Ser Gln Cys Lys Lys Lys Lys 
                485                 490                 495     


Lys Lys Lys Lys Thr Lys Cys Val Ile Met 
            500                 505     


<210> 317
<211> 288
<212> PRT
<213> Mus musculus

<400> 317
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 318
<211> 7796
<212> DNA
<213> Homo sapiens

<400> 318
ggggccgggg ggcggagcct tgcgggctgg agcgaaagaa tgcgggggct gagcgcagaa       60

gcggctcgag gctggaagag gatcttgggc gccgccagtc tctctctgtt gcccaagctg      120

gagtgcagtg gcacagtctt ggctcactgc aacctccacc tcctgggtgc aagcgattct      180

cgtgtctcag cctctcaagt agctgggatt acagtcttta gcaccagttg gtgtaggagt      240

tgagacctac ttcacagtag ttctgtggac aatcacaatg ggaatccaag gagggtctgt      300

cctgttcggg ctgctgctcg tcctggctgt cttctgccat tcaggtcata gcctgcagtg      360

ctacaactgt cctaacccaa ctgctgactg caaaacagcc gtcaattgtt catctgattt      420

tgatgcgtgt ctcattacca aagctgggtt acaagtgtat aacaagtgtt ggaagtttga      480

gcattgcaat ttcaacgacg tcacaacccg cttgagggaa aatgagctaa cgtactactg      540

ctgcaagaag gacctgtgta actttaacga acagcttgaa aatggtggga catccttatc      600

agagaaaaca gttcttctgc tggtgactcc atttctggca gcagcctgga gccttcatcc      660

ctaagtcaac accaggagag cttctcccaa actccccgtt cctgcgtagt ccgctttctc      720

ttgctgccac attctaaagg cttgatattt tccaaatgga tcctgttggg aaagaataaa      780

attagcttga gcaacctggc taagatagag gggctctggg agactttgaa gaccagtcct      840

gtttgcaggg aagccccact tgaaggaaga agtctaagag tgaagtaggt gtgacttgaa      900

ctagattgca tgcttcctcc tttgctcttg ggaagaccag ctttgcagtg acagcttgag      960

tgggttctct gcagccctca gattattttt cctctggctc cttggatgta gtcagttagc     1020

atcattagta catctttgga gggtggggca ggagtatatg agcatcctct ctcacatgga     1080

acgctttcat aaacttcagg gatcccgtgt tgccatggag gcatgccaaa tgttccatat     1140

gtgggtgtca gtcagggaca acaagatcct taatgcagag ctagaggact tctggcaggg     1200

aagtggggaa gtgttccaga tagcagggca tgaaaactta gagaggtaca agtggctgaa     1260

aatcgagttt ttcctctgtc tttaaatttt atatgggctt tgttatcttc cactggaaaa     1320

gtgtaatagc atacatcaat ggtgtgttaa agctatttcc ttgccttttt tttattggaa     1380

tggtaggata tcttggcttt gccacacaca gttacagagt gaacactcta ctacatgtga     1440

ctggcagtat taagtgtgct tattttaaat gttactggta gaaaggcagt tcaggtatgt     1500

gtgtatatag tatgaatgca gtggggacac cctttgtggt tacagtttga gacttccaaa     1560

ggtcatcctt aataacaaca gatctgcagg ggtatgtttt accatctgca tccagcctcc     1620

tgctaactcc tagctgactc agcatagatt gtataaaata cctttgtaac ggctcttagc     1680

acactcacag atgtttgagg ctttcagaag ctcttctaaa aaatgataca cacctttcac     1740

aagggcaaac tttttccttt tccctgtgta ttctagtgaa tgaatctcaa gattcagtag     1800

acctaatgac atttgtattt tatgatcttg gctgtattta atggcatagg ctgacttttg     1860

cagatggagg aatttcttga ttaatgttga aaaaaaaccc ttgattatac tctgttggac     1920

aaaccgagtg caatgaatga tgcttttctg aaaatgaaat ataacaagtg ggtgaatgtg     1980

gttatggccg aaaaggatat gcagtatgct taatggtagc aactgaaaga agacatcctg     2040

agcagtgcca gctttcttct gttgatgccg ttccctgaac ataggaaaat agaaacttgc     2100

ttatcaaaac ttagcattac cttggtgctc tgtgttctct gttagctcag tgtctttcct     2160

tacatcaata ggtttttttt tttttttttg gcctgaggaa gtactgacca tgcccacagc     2220

caccggctga gcaaagaagc tcatttcatg tgagttctaa ggaatgagaa acaattttga     2280

tgaatttaag cagaaaatga atttctggga acttttttgg gggcgggggg gtggggaatt     2340

cagccacact ccagaaagcc aggagtcgac agttttggaa gcctctctca ggattgagat     2400

tctaggatga gattggctta ctgctatctt gtgtcatgta cccacttttt ggccagacta     2460

cactgggaag aaggtagtcc tctaaagcaa aatctgagtg ccactaaatg gggagatggg     2520

gctgttaagc tgtccaaatc aacaagggtc atataaatgg ccttaaactt tggggttgct     2580

ttctgcaaaa agttgctgtg actcatgcca tagacaaggt tgagtgcctg gacccaaagg     2640

caatactgta atgtaaagac atttatagta ctaggcaaac agcaccccag gtactccagg     2700

ccctcctggc tggagagggc tgtggcaata gaaaattagt gccaactgca gtgagtcagc     2760

ctaggttaaa tagagagtgt aagagtgctg gacaggaacc tccaccctca tgtcacattt     2820

cttcaatgtg acccttctgg cccctctcct cctgacagcg gaacaatgac tgccccgata     2880

ggtgaggctg gaggaagaat cagtcctgtc cttggcaagc tcttcactat gacagtaaag     2940

gctctctgcc tgctgccaag gcctgtgact ttctaacctg gcctcacgct gggtaagctt     3000

aaggtagagg tgcaggatta gcaagcccac ctggctacca ggccgacagc tacatcctcc     3060

aactgaccct gatcaacgaa gagggattca tgtgtctgtc tcagttggtt ccaaatgaaa     3120

ccagggagca ggggagttag gaatcgaaca ccagtcatgc ctactggctc tctgctcgag     3180

agccaatacc ctgtgccctc cactcatctg gatttacagg aactgtcata gtgttcagta     3240

ttgggtggtg ataagcccat tggattgtcc ccttgggggg atgagctagg ggtgcaagga     3300

acacctgatg agtagataag tggagctcat ggtatttcct gaaagatgct aatctatttg     3360

ccaaacttgg tcttgaatgt actgggggct tcaaggtatg ggtatatttt tcttgtgtcc     3420

ttgcagttag cccccatgtc ttatgtgtgt cctgaaaaaa taagagcctg cccaagactt     3480

tgggcctctt gacagaatta accactttta tacatctgag ttctcttggt aagttcttta     3540

gcagtgttca aagtctacta gctcgcatta gtttctgttg ctgccaacag atctgaacta     3600

atgctaacag atccccctga gggattcttg atgggctgag cagctggctg gagctagtac     3660

tgactgacat tcattgtgat gagggcagct ttctggtaca ggattctaag ctctatgttt     3720

tatatacatt ttcatctgta cttgcacctc actttacaca agaggaaact atgcaaagtt     3780

agctggatcg ctcaaggtca cttaggtaag ttggcaagtc catgcttccc actcagctcc     3840

tcaggtcagc aagtctactt ctctgcctat tttgtatact ctctttaata tgtgcctagc     3900

tttggaaagt ctagaatggg tccctggtgc ctttttactt tgaagaaatc agtttctgcc     3960

tctttttgga aaagaaaaca aagtgcaatt gttttttact ggaaagttac ccaatagcat     4020

gaggtgaaca ggacgtagtt aggccttcct gtaaacagaa aatcatatca aaacactatc     4080

ttcccatctg tttctcaatg cctgctactt cttgtagata tttcatttca ggagagcagc     4140

agttaaaccc gtggattttg tagttaggaa cctgggttca aaccctcttc cactaattgg     4200

ctatgtctct ggacaagttt tttttttttt ttttttttaa accctttctg aactttcact     4260

ttctatgtct acctcaaaga attgttgtga ggcttgagat aatgcatttg taaagggtct     4320

gccagatagg aagatgctag ttatggattt acaaggttgt taaggctgta agagtctaaa     4380

acctacagtg aatcacaatg catttacccc cactgacttg gacataagtg aaaactagcc     4440

agaagtctct ttttcaaatt acttacaggt tattcaatat aaaatttttg taatggataa     4500

tcttatttat ctaaactaaa gcttcctgtt tatacacact cctgttattc tgggataaga     4560

taaatgacca cagtacctta atttctaggt gggtgcctgt gatggttcat tgtaggtaag     4620

gacattttct ctttttcagc agctgtgtag gtccagagcc tctgggagag gaggggggta     4680

gcatgcaccc agcaggggac tgaactggga aactcaaggt tctttttact gtggggtagt     4740

gagctgcctt tctgtgatcg gtttccctag ggatgttgct gttcccctcc ttgctattcg     4800

cagctacata caacgtggcc aaccccagta ggctgatcct atatatgatc agtgctggtg     4860

ctgactctca atagccccac ccaagctggc tataggttta cagatacatt aattaggcaa     4920

cctaaaatat tgatgctggt gttggtgtga cataatgcta tggccagaac tgaaacttag     4980

agttataatt catgtattag ggttctccag agggacagaa ttagtaggat atatgtatat     5040

atgaaaggga ggttattagg gagaactggc tcccacagtt agaaggcgaa gtcgcacaat     5100

aggccgtctg caagctgggt tagagagaag ccagtagtgg ctcagcctga gttcaaaaac     5160

ctcaaaactg gggaagctga cagtgcagcc agccttcagt ctgtggccaa aggcccaaga     5220

gcccctggca accaacccac tggtgcaagt cctagattcc aaaggctgaa gaacctggag     5280

tctgatgtcc aagagcagga agagtggaag aaagccagaa gactcagcaa acaaggtaga     5340

cagtgtctac caccatagtg gccataccaa agaggctacc gattccttcc tgctacctgg     5400

atccctgaag ttgccctggt ctctgcacct tctaaaccta gttcttaaga gctttccatt     5460

acatgagctg tctcaaagcc ctccaataaa ttctcagtgt aagcttctgt tgcttgtgga     5520

cagaaaattc tgacagacct accctataag tgttactgtc aggataacat gagaacgcac     5580

aacagtaagt ggtcactaag tgttagctac ggttattttg cccaaggtag catggctagt     5640

tgatgccggt tgatggggct taaacccagc tccctcatct tccaggcctc tgtactccct     5700

attccactaa actacctctc aggtttattt ttttaaattc ttactctgca agtacatagg     5760

accacattta cctgggaaaa caagaataaa ggctgctctg cattttttag aaactttttt     5820

gaaagggaga tgggaatgcc tgcaccccca agtccagacc aacacaatgg ttaattgaga     5880

tgaataataa aggaaagact gttctgggct tcccagaata gcttggtcct taaattgtgg     5940

cacaaacaac ctcctgtcag agccagcctc ctgccaggaa gaggggtagg agactagagg     6000

ccgtgtgtgc agccttgccc tgaaggctag ggtgacaatt tggaggctgt ccaaacaccc     6060

tggcctctag agctggcctg tctatttgaa atgccggctc tgatgctaat cggcgaccct     6120

caggcaagtt acttaacctt acatgcctca gttttctcat ctggaaaatg agaaccctag     6180

gtttagggtt gttagaaaag ttaaatgagt taagacaagt gcctgggaca cagtagcctc     6240

ttgtgtgtgt ttatcattat gtcctcagca ggtcgtagaa gcagcttctc aggtgtgagg     6300

ctggcgcgat tatctggagt gggttgggtt ttctaggatg gaccccctgc tgcattttcc     6360

tcattcatcc accagggctt aatggggaat caaggaatcc atgtgtaact gtataataac     6420

tgtagccaca ctccaatgac cacctactag ttgtccctgg cactgcttat acatatgtcc     6480

atcaaatcaa tcctatgaag tagatactgt cttcatttta tagatcagag acaattgggg     6540

ttcagagagc tgatgtgatt ttcccagggt cacagagagt cccagattca ggcacaactc     6600

ttgtattcca agacacaacc actacatgtc caaaggctgc ccagagccac cgggcacggc     6660

aaattgtgac atatccctaa agaggctgag cacctggtca ggatctgatg gctgacagtg     6720

tgtccagatg cagagctgga gtgggggagg ggaagggggg ctccttggga cagagaaggc     6780

tttctgtgct ttctctgaag ggagcagtct gaggaccaag ggaacccggc aaacagcacc     6840

tcaggtactc caggccctcc tggctggaga gggctgtggc aatggaaaat tagtgccaac     6900

tgcaatgagt cagcctcggt taaatagaga gtgaagaatg ctggacagga acctccaccc     6960

tcatgtcaca tttcttcagt gtgacccttc tggcccctct cctcctgaca gcggaacaat     7020

gactgccccg ataggtgagg ctggaggaag aatcagtcct gtccttggca agctcttcac     7080

tatgacagta aaggctctct gcctgctgcc aaggcctgtg actttctaac ctggcctcac     7140

gctgggtaag cttaaggtag aggtgcagga ttagcaagcc cacctggcta ccaggccgac     7200

agctacatct ttcaactgac cctgatcaac gaagagggac ttgtgtctct cagttggttc     7260

caaatgaaac cagggagcag gggcgttagg aagctccaac aggatggtac ttaatggggc     7320

atttgagtgg agaggtaggt gacatagtgc tttggagccc agggagggaa aggttctgct     7380

gaagttgaat tcaagactgt tctttcatca caaacttgag tttcctggac atttgtttgc     7440

agaaacaacc gtagggtttt gccttaacct cgtgggttta ttattacctc atagggactt     7500

tgcctcctga cagcagttta tgggtgttca ttgtggcact tgagttttct tgcatacttg     7560

ttagagaaac caagtttgtc atcaacttct tatttaaccc cctggctata acttcatgga     7620

ttatgttata attaagccat ccagagtaaa atctgtttag attatcttgg agtaaggggg     7680

aaaaaatctg taattttttc tcctcaacta gatatataca taaaaaatga ttgtattgct     7740

tcatttaaaa aatataacgc aaaatctctt ttccttctaa aaaaaaaaaa aaaaaa         7796


<210> 319
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 319
Gly Ser Ser Gly 
1               


