                               SEQUENCE LISTING

<110> PERSEUS SCIENCE GROUP, LLC
 
<120> IN VITRO METHOD FOR DIAGNOSING CENTRAL NERVOUS SYSTEM INJURY

<130> 009383.00001\WO

<140> PCT/US2021/016740
<141> 2021-02-05

<150> 62/970,769
<151> 2020-02-06

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 697
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg 
1               5                   10                  15      


Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu 
            20                  25                  30          


Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe 
        35                  40                  45              


Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu 
    50                  55                  60                  


Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe 
65                  70                  75                  80  


Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp 
                85                  90                  95      


Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr 
            100                 105                 110         


Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly 
        115                 120                 125             


Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg 
    130                 135                 140                 


Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg 
145                 150                 155                 160 


Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr 
                165                 170                 175     


Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr 
        195                 200                 205             


Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn 
    210                 215                 220                 


Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala 
    290                 295                 300                 


Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser 
305                 310                 315                 320 


Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg 
                325                 330                 335     


Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser 
            340                 345                 350         


Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala 
        355                 360                 365             


Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys 
    370                 375                 380                 


Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys 
385                 390                 395                 400 


Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe 
                405                 410                 415     


Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe 
            420                 425                 430         


Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln 
        435                 440                 445             


Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile 
    450                 455                 460                 


Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp 
465                 470                 475                 480 


Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile 
                485                 490                 495     


Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr 
            500                 505                 510         


Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala 
        515                 520                 525             


Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu 
    530                 535                 540                 


Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu 
545                 550                 555                 560 


Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys 
                565                 570                 575     


Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys 
            580                 585                 590         


His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile 
        595                 600                 605             


Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg 
    610                 615                 620                 


Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly 
625                 630                 635                 640 


Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro 
                645                 650                 655     


Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly 
            660                 665                 670         


Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
        675                 680                 685             


Thr Ser Pro Val Pro Val Pro Val Met 
    690                 695         


<210> 2

<400> 2
000


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Phe Ser Leu Asn Tyr Tyr Ala 
1               5               


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ile Thr Ser Asp Thr Thr 
1               5       


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ala Ser Gly Gly Ser Thr Thr Ser Pro Ala Leu 
1               5                   10      


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Ser Val Trp Ser Lys Asn Tyr 
1               5               


<210> 7
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Ser Ala Ser 
1           


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Leu Gly Ser Tyr Asp Cys Arg Ser Ala Asp Cys Trp Thr 
1               5                   10              


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gly Phe Ser Leu Ser Ser Tyr Ala 
1               5               


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ile Ile Ser Gly Gly Ser Ala 
1               5           


<210> 11
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ala Arg Ala Lys Ser Gly Thr Tyr Thr Gly Asp Tyr Phe Thr Leu 
1               5                   10                  15  


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Glu Ser Ile Gly Asn Ala 
1               5       


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Arg Ala Ser 
1           


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gln Ser Tyr Val Gly Ser Arg Ser Thr Gly Tyr Asn Val 
1               5                   10              


<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Phe Thr Leu Thr Thr Tyr Trp 
1               5               


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ile Leu Thr Gly Ser Gly Ser Thr 
1               5               


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Arg Tyr Gly Gly Asp Ala Thr Tyr Asn Glu Asn Leu 
1               5                   10              


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gln Ser Val Tyr Asn Asn Asn Arg 
1               5               


<210> 19
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Val Ser 
1           


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Leu Gly Gly Tyr Asp Cys Ala Ser Ala Asp Cys Tyr Ala 
1               5                   10              


<210> 21
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Ala Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn 
        35                  40                  45              


Tyr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Val Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Val Ile Thr Ser Asp Thr Thr Tyr Tyr Ala Ser Trp Ala 
65                  70                  75                  80  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Glu Leu Gln 
                85                  90                  95      


Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Gly Ser Thr Thr Ser Pro Ala Leu Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210> 22
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ser Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Trp Ser Lys Asn Tyr Leu Ser Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Gln Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Asp Cys Arg Ser Ala Asp Cys Trp Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210> 23
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Leu Ser Arg Asn Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Thr Gly Ile Ile Phe Gly Asp Ala Lys Thr Tyr Tyr Ala 
65                  70                  75                  80  


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ala Thr Thr Val 
                85                  90                  95      


Asp Leu Lys Ile Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Val Ala Gly Thr Gly Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 24
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Ser Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Tyr Asn Lys Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Ser Ser Ser Thr Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Ser Tyr Asp Cys Ser Ser Ala Asp Cys Asn Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210> 25
<211> 137
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro 
            20                  25                  30          


Gly Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Leu Thr 
        35                  40                  45              


Thr Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Cys Ile Leu Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
65                  70                  75                  80  


Trp Val Asn Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
                85                  90                  95      


Thr Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Ala Arg Tyr Gly Gly Asp Ala Thr Tyr Asn Glu Asn Leu Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135         


<210> 26
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Ser Val Tyr Asn Asn Asn Arg Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Gly Val Ser Thr Leu Tyr Tyr 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Gly Met Gln Cys Asp Asp Ala Ala Ile Tyr Tyr Cys 
            100                 105                 110         


Leu Gly Gly Tyr Asp Cys Ala Ser Ala Asp Cys Tyr Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210> 27

<400> 27
000


<210> 28

<400> 28
000


<210> 29

<400> 29
000


<210> 30
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Ser Asn Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Gly Phe Ser Gly Ser Thr Asn Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Gly Gly Leu Asn Ile Gly Met Asn Leu Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210> 31
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Pro Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Val Tyr Tyr Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Gly Tyr Gly Asp Thr Asn Gly Gly Ala Ser Ser Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210> 32
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Gly Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Glu Gln Leu Lys Glu Ser Gly Gly Gly Leu Val Thr 
            20                  25                  30          


Pro Gly Gly Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ile Ile Ile Ser Gly Gly Ser Ala Tyr Tyr Ala Thr 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Ser Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Ala Lys Ser Gly Thr Tyr Thr Gly Asp Tyr Phe Thr Leu Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135             


<210> 33
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Phe Glu Leu Thr Gln Thr Pro Ala Ser 
            20                  25                  30          


Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 
        35                  40                  45              


Glu Ser Ile Gly Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Tyr Val Gly Ser Arg Ser Thr Gly Tyr Asn Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Glu Val Val Val Lys 
    130             


<210> 34
<211> 672
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210> 35
<211> 10
<212> PRT
<213> Homo sapiens

<400> 35
Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro 
1               5                   10  


<210> 36
<211> 25
<212> PRT
<213> Homo sapiens

<400> 36
Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro 
1               5                   10                  15      


Thr Ser Pro Val Pro Val Pro Val Met 
            20                  25  


<210> 37
<211> 13
<212> PRT
<213> Homo sapiens

<400> 37
Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly 
1               5                   10              


<210> 38
<211> 303
<212> PRT
<213> Homo sapiens

<400> 38
Cys Thr Leu Val Glu Lys Arg Val Leu Ala Leu Gly Gly Arg Gly Pro 
1               5                   10                  15      


Gly Gly Arg Pro His Phe Leu Thr Gln Leu His Ser Thr Phe Gln Thr 
            20                  25                  30          


Pro Asp Arg Leu Tyr Phe Val Met Glu Tyr Val Thr Gly Gly Asp Leu 
        35                  40                  45              


Met Tyr His Ile Gln Gln Leu Gly Lys Phe Lys Glu Pro His Ala Ala 
    50                  55                  60                  


Phe Tyr Ala Ala Glu Ile Ala Ile Gly Leu Phe Phe Leu His Asn Gln 
65                  70                  75                  80  


Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ala 
                85                  90                  95      


Glu Gly His Ile Lys Ile Thr Asp Phe Gly Met Cys Lys Glu Asn Val 
            100                 105                 110         


Phe Pro Gly Thr Thr Thr Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile 
        115                 120                 125             


Ala Pro Glu Ile Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp 
    130                 135                 140                 


Trp Ser Phe Gly Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro 
145                 150                 155                 160 


Phe Asp Gly Glu Asp Glu Glu Glu Leu Phe Gln Ala Ile Met Glu Gln 
                165                 170                 175     


Thr Val Thr Tyr Pro Lys Ser Leu Ser Arg Glu Ala Val Ala Ile Cys 
            180                 185                 190         


Lys Gly Phe Leu Thr Lys His Pro Gly Lys Arg Leu Gly Ser Gly Pro 
        195                 200                 205             


Asp Gly Glu Pro Thr Ile Arg Ala His Gly Phe Phe Arg Trp Ile Asp 
    210                 215                 220                 


Trp Glu Arg Leu Glu Arg Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg 
225                 230                 235                 240 


Pro Cys Gly Arg Ser Gly Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala 
                245                 250                 255     


Ala Pro Ala Leu Thr Pro Pro Asp Arg Leu Val Leu Ala Ser Ile Asp 
            260                 265                 270         


Gln Ala Asp Phe Gln Gly Phe Thr Tyr Val Asn Pro Asp Phe Val His 
        275                 280                 285             


Pro Asp Ala Arg Ser Pro Thr Ser Pro Val Pro Val Pro Val Met 
    290                 295                 300             


