                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> LARGE GENE VECTORS AND DELIVERY AND USES THEREOF

<130> 167705.020601/PCT

<140> PCT/US2021/016720
<141> 2021-02-05

<150> 62/971,555
<151> 2020-02-07

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 5262
<212> DNA
<213> Homo sapiens

<400> 1
gtgactctgg cccctactgg gcctcattcc ctggaccctg gtctctcctt cctgaagtca       60

ttgctctcca ctctggacca ggctccccag ggctccctga gccgctcacg gttctttaca      120

ttcctggcca acatttcttc ttcctttgag cctgggagaa tgggggaagg accagtagga      180

gagcccccac ctctccagcc gcctgctctg cggctccatg attttctagt gacactgaga      240

ggtagccccg actgggagcc aatgctaggg ctgctagggg atatgctggc actgctggga      300

caggagcaga ctccccgaga tttcctggtg caccaggcag gggtgctggg tggacttgtg      360

gaggtgctgc tgggagcctt agttcctggg ggccccccta ccccaactcg gcccccatgc      420

acccgtgatg ggccgtctga ctgtgtcctg gctgctgact ggttgccttc tctgctgctg      480

ttgttagagg gcacacgctg gcaagctctg gtgcaggtgc agcccagtgt ggaccccacc      540

aatgccacag gcctcgatgg gagggaggca gctcctcact ttttgcaggg tctgttgggt      600

ttgcttaccc caacagggga gctaggctcc aaggaggctc tttggggcgg tctgctacgc      660

acagtggggg cccccctcta tgctgccttt caggaggggc tgctccgtgt cactcactcc      720

ctgcaggatg aggtcttctc cattttgggg cagccagagc ctgataccaa tgggcagtgc      780

cagggaggta accttcaaca gctgctctta tggggcgtcc ggcacaacct ttcctgggat      840

gtccaggcgc tgggctttct gtctggatca ccacccccac cccctgccct ccttcactgc      900

ctgagcacgg gcgtgcctct gcccagagct tctcagccgt cagcccacat cagcccacgc      960

caacggcgag ccatcactgt ggaggccctc tgtgagaacc acttaggccc agcaccaccc     1020

tacagcattt ccaacttctc catccacttg ctctgccagc acaccaagcc tgccactcca     1080

cagccccatc ccagcaccac tgccatctgc cagacagctg tgtggtatgc agtgtcctgg     1140

gcaccaggtg cccaaggctg gctacaggcc tgccacgacc agtttcctga tgagtttttg     1200

gatgcgatct gcagtaacct ctccttttca gccctgtctg gctccaaccg ccgcctggtg     1260

aagcggctct gtgctggcct gctcccaccc cctaccagct gccctgaagg cctgccccct     1320

gttcccctca ccccagacat cttttggggc tgcttcttgg agaatgagac tctgtgggct     1380

gagcgactgt gtggggaggc aagtctacag gctgtgcccc ccagcaacca ggcttgggtc     1440

cagcatgtgt gccagggccc caccccagat gtcactgcct ccccaccatg ccacattgga     1500

ccctgtgggg aacgctgccc ggatgggggc agcttcctgg tgatggtctg tgccaatgac     1560

accatgtatg aggtcctggt gcccttctgg ccttggctag caggccaatg caggataagt     1620

cgtgggggca atgacacttg cttcctagaa gggctgctgg gcccccttct gccctctctg     1680

ccaccactgg gaccatcccc actctgtctg acccctggcc ccttcctcct tggcatgcta     1740

tcccagttgc cacgctgtca gtcctctgtc ccagctcttg ctcaccccac acgcctacac     1800

tatctcctcc gcctgctgac cttcctcttg ggtccagggg ctgggggcgc tgaggcccag     1860

gggatgctgg gtcgggccct actgctctcc agtctcccag acaactgctc cttctgggat     1920

gcctttcgcc cagagggccg gcgcagtgtg ctacggacga ttggggaata cctggaacaa     1980

gatgaggagc agccaacccc atcaggcttt gaacccactg tcaaccccag ctctggtata     2040

agcaagatgg agctgctggc ctgctttagt cctgtgctgt gggatctgct ccagagggaa     2100

aagagtgttt gggccctgca gattctagtg caggcgtacc tgcatatgcc cccagaaaac     2160

ctccagcagc tggtgctttc agcagagagg gaggctgcac agggcttcct gacactcatg     2220

ctgcagggga agctgcaggg gaagctgcag gtaccaccat ccgaggagca ggccctgggt     2280

cgcctgacag ccctgctgct ccagcggtac ccacgcctca cctcccagct cttcattgac     2340

ctgtcaccac tcatcccttt cttggctgtc tctgacctga tgcgcttccc accatccctg     2400

ttagccaacg acagtgtcct ggctgccatc cgggattaca gcccaggaat gaggcctgaa     2460

cagaaggagg ctctggcaaa gcgactgctg gcccctgaac tgtttgggga agtgcctgcc     2520

tggccccagg agctgctgtg ggcagtgctg cccctgctcc cccacctccc tctggagaac     2580

tttttgcagc tcagccctca ccagatccag gccctggagg atagctggcc agcagcaggt     2640

ctggggccag ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat     2700

ggtgaggagc aggtacgcag gcttgggccc ctcgcctgtt tcctgagccc tgaggagctg     2760

cagagcctag tgcccctgag tgatccaacg gggccagtag aacgggggct gctggaatgt     2820

gcagccaatg ggaccctcag cccagaagga cgggtggcat atgaacttct gggtgtgttg     2880

cgctcatctg gaggagcggt gctgagcccc cgggagctgc gggtctgggc ccctctcttc     2940

tctcagctgg gcctccgctt ccttcaggag ctgtcagagc cccagcttag agccatgctt     3000

cctgtcctgc agggaactag tgttacacct gctcaggctg tcctgctgct tggacggctc     3060

cttcctaggc acgatctatc cctggaggaa ctctgctcct tgcaccttct gctaccaggc     3120

ctcagccccc agacactcca ggccatccct aggcgagtcc tggtcggggc ttgttcctgc     3180

ctggcccctg aactgtcacg cctctcagcc tgccagaccg cagcactgct gcagaccttt     3240

cgggttaaag atggtgttaa aaatatgggt acaacaggtg ctggtccagc tgtgtgtatc     3300

cctggtcagc ctattcccac cacctggcca gactgcctgc ttcccctgct cccattaaag     3360

ctgctacaac tggattcctt ggctcttctg gcaaatcgaa gacgctactg ggagctgccc     3420

tggtctgagc agcaggcaca gtttctctgg aagaagatgc aagtacccac caaccttacc     3480

ctcaggaatc tgcaggctct gggcaccctg gcaggaggca tgtcctgtga gtttctgcag     3540

cagatcaact ccatggtaga cttccttgaa gtggtgcaca tgatctatca gctgcccact     3600

agagttcgag ggagcctgag ggcctgtatc tgggcagagc tacagcggag gatggcaatg     3660

ccagaaccag aatggacaac tgtagggcca gaactgaacg ggctggatag caagctactc     3720

ctggacttac cgatccagtt gatggacaga ctatccaatg aatccattat gttggtggtg     3780

gagctggtgc aaagagctcc agagcagctg ctggcactga cccccctcca ccaggcagcc     3840

ctggcagaga gggcactaca aaacctggct ccaaaggaga ctccagtctc aggggaagtg     3900

ctggagacct taggcccttt ggttggattc ctggggacag agagcacacg acagatcccc     3960

ctacagatcc tgctgtccca tctcagtcag ctgcaaggct tctgcctagg agagacattt     4020

gccacagagc tgggatggct gctattgcag gagtctgttc ttgggaaacc agagttgtgg     4080

agccaggatg aagtagagca agctggacgc ctagtattca ctctgtctac tgaggcaatt     4140

tccttgatcc ccagggaggc cttgggtcca gagaccctgg agcggcttct agaaaagcag     4200

cagagctggg agcagagcag agttggacag ctgtgtaggg agccacagct tgctgccaag     4260

aaagcagccc tggtagcagg ggtggtgcga ccagctgctg aggatcttcc agaacctgtg     4320

ccaaattgtg cagatgtacg agggacattc ccagcagcct ggtctgcaac ccagattgca     4380

gagatggagc tctcagactt tgaggactgc ctgacattat ttgcaggaga cccaggactt     4440

gggcctgagg aactgcgggc agccatgggc aaagcaaaac agttgtgggg tcccccccgg     4500

ggatttcgtc ctgagcagat cctgcagctt ggtaggctct taataggtct aggagatcgg     4560

gaactacagg agctgatcct agtggactgg ggagtgctga gcaccctggg gcagatagat     4620

ggctggagca ccactcagct ccgcattgtg gtctccagtt tcctacggca gagtggtcgg     4680

catgtgagcc acctggactt cgttcatctg acagcgctgg gttatactct ctgtggactg     4740

cggccagagg agctccagca catcagcagt tgggagttca gccaagcagc tctcttcctc     4800

ggcaccctgc atctccagtg ctctgaggaa caactggagg ttctggccca cctacttgta     4860

ctgcctggtg ggtttggccc aatcagtaac tgggggcctg agatcttcac tgaaattggc     4920

accatagcag ctgggatccc agacctggct ctttcagcac tgctgcgggg acagatccag     4980

ggcgttactc ctcttgccat ttctgtcatc cctcctccta aatttgctgt ggtgtttagt     5040

cccatccaac tatctagtct caccagtgct caggctgtgg ctgtcactcc tgagcaaatg     5100

gcctttctga gtcctgagca gcgacgagca gttgcatggg cccaacatga gggaaaggag     5160

agcccagaac agcaaggtcg aagtacagcc tggggcctcc aggactggtc acgaccttcc     5220

tggtccctgg tattgactat cagcttcctt ggccacctgc ta                        5262


<210> 2
<211> 1754
<212> PRT
<213> Homo sapiens

<400> 2
Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu Asp Pro Gly Leu Ser 
1               5                   10                  15      


Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln Ala Pro Gln Gly Ser 
            20                  25                  30          


Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala Asn Ile Ser Ser Ser 
        35                  40                  45              


Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val Gly Glu Pro Pro Pro 
    50                  55                  60                  


Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val Thr Leu Arg 
65                  70                  75                  80  


Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly Asp Met Leu 
                85                  90                  95      


Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu Val His Gln 
            100                 105                 110         


Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu Leu Gly Ala Leu Val 
        115                 120                 125             


Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro Cys Thr Arg Asp Gly 
    130                 135                 140                 


Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Val Gln Pro Ser 
                165                 170                 175     


Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu Ala Ala Pro 
            180                 185                 190         


His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Thr Gly Glu Leu 
        195                 200                 205             


Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr Val Gly Ala 
    210                 215                 220                 


Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val Thr His Ser 
225                 230                 235                 240 


Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln Pro Glu Pro Asp Thr 
                245                 250                 255     


Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu Leu Trp Gly 
            260                 265                 270         


Val Arg His Asn Leu Ser Trp Asp Val Gln Ala Leu Gly Phe Leu Ser 
        275                 280                 285             


Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu Ser Thr Gly 
    290                 295                 300                 


Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala His Ile Ser Pro Arg 
305                 310                 315                 320 


Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys Glu Asn His Leu Gly 
                325                 330                 335     


Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile His Leu Leu Cys 
            340                 345                 350         


Gln His Thr Lys Pro Ala Thr Pro Gln Pro His Pro Ser Thr Thr Ala 
        355                 360                 365             


Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala 
    370                 375                 380                 


Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe Pro Asp Glu Phe Leu 
385                 390                 395                 400 


Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala Leu Ser Gly Ser Asn 
                405                 410                 415     


Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr 
            420                 425                 430         


Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu Thr Pro Asp Ile Phe 
        435                 440                 445             


Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys 
    450                 455                 460                 


Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser Asn Gln Ala Trp Val 
465                 470                 475                 480 


Gln His Val Cys Gln Gly Pro Thr Pro Asp Val Thr Ala Ser Pro Pro 
                485                 490                 495     


Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe 
            500                 505                 510         


Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr Glu Val Leu Val Pro 
        515                 520                 525             


Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn 
    530                 535                 540                 


Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro Leu Leu Pro Ser Leu 
545                 550                 555                 560 


Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr Pro Gly Pro Phe Leu 
                565                 570                 575     


Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala 
            580                 585                 590         


Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe 
        595                 600                 605             


Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala Gln Gly Met Leu Gly 
    610                 615                 620                 


Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp 
625                 630                 635                 640 


Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Ile Gly Glu 
                645                 650                 655     


Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro Ser Gly Phe Glu Pro 
            660                 665                 670         


Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met Glu Leu Leu Ala Cys 
        675                 680                 685             


Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp 
    690                 695                 700                 


Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His Met Pro Pro Glu Asn 
705                 710                 715                 720 


Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu Ala Ala Gln Gly Phe 
                725                 730                 735     


Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly Lys Leu Gln Val Pro 
            740                 745                 750         


Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr Ala Leu Leu Leu Gln 
        755                 760                 765             


Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile Asp Leu Ser Pro Leu 
    770                 775                 780                 


Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg Phe Pro Pro Ser Leu 
785                 790                 795                 800 


Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg Asp Tyr Ser Pro Gly 
                805                 810                 815     


Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys Arg Leu Leu Ala Pro 
            820                 825                 830         


Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln Glu Leu Leu Trp Ala 
        835                 840                 845             


Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu Asn Phe Leu Gln Leu 
    850                 855                 860                 


Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser Trp Pro Ala Ala Gly 
865                 870                 875                 880 


Leu Gly Pro Gly His Ala Arg His Val Leu Arg Ser Leu Val Asn Gln 
                885                 890                 895     


Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg Leu Gly Pro Leu Ala 
            900                 905                 910         


Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu Val Pro Leu Ser Asp 
        915                 920                 925             


Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu Cys Ala Ala Asn Gly 
    930                 935                 940                 


Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu Leu Leu Gly Val Leu 
945                 950                 955                 960 


Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg Glu Leu Arg Val Trp 
                965                 970                 975     


Ala Pro Leu Phe Ser Gln Leu Gly Leu Arg Phe Leu Gln Glu Leu Ser 
            980                 985                 990         


Glu Pro Gln Leu Arg Ala Met Leu  Pro Val Leu Gln Gly  Thr Ser Val 
        995                 1000                 1005             


Thr Pro  Ala Gln Ala Val Leu  Leu Leu Gly Arg Leu  Leu Pro Arg 
    1010                 1015                 1020             


His Asp  Leu Ser Leu Glu Glu  Leu Cys Ser Leu His  Leu Leu Leu 
    1025                 1030                 1035             


Pro Gly  Leu Ser Pro Gln Thr  Leu Gln Ala Ile Pro  Arg Arg Val 
    1040                 1045                 1050             


Leu Val  Gly Ala Cys Ser Cys  Leu Ala Pro Glu Leu  Ser Arg Leu 
    1055                 1060                 1065             


Ser Ala  Cys Gln Thr Ala Ala  Leu Leu Gln Thr Phe  Arg Val Lys 
    1070                 1075                 1080             


Asp Gly  Val Lys Asn Met Gly  Thr Thr Gly Ala Gly  Pro Ala Val 
    1085                 1090                 1095             


Cys Ile  Pro Gly Gln Pro Ile  Pro Thr Thr Trp Pro  Asp Cys Leu 
    1100                 1105                 1110             


Leu Pro  Leu Leu Pro Leu Lys  Leu Leu Gln Leu Asp  Ser Leu Ala 
    1115                 1120                 1125             


Leu Leu  Ala Asn Arg Arg Arg  Tyr Trp Glu Leu Pro  Trp Ser Glu 
    1130                 1135                 1140             


Gln Gln  Ala Gln Phe Leu Trp  Lys Lys Met Gln Val  Pro Thr Asn 
    1145                 1150                 1155             


Leu Thr  Leu Arg Asn Leu Gln  Ala Leu Gly Thr Leu  Ala Gly Gly 
    1160                 1165                 1170             


Met Ser  Cys Glu Phe Leu Gln  Gln Ile Asn Ser Met  Val Asp Phe 
    1175                 1180                 1185             


Leu Glu  Val Val His Met Ile  Tyr Gln Leu Pro Thr  Arg Val Arg 
    1190                 1195                 1200             


Gly Ser  Leu Arg Ala Cys Ile  Trp Ala Glu Leu Gln  Arg Arg Met 
    1205                 1210                 1215             


Ala Met  Pro Glu Pro Glu Trp  Thr Thr Val Gly Pro  Glu Leu Asn 
    1220                 1225                 1230             


Gly Leu  Asp Ser Lys Leu Leu  Leu Asp Leu Pro Ile  Gln Leu Met 
    1235                 1240                 1245             


Asp Arg  Leu Ser Asn Glu Ser  Ile Met Leu Val Val  Glu Leu Val 
    1250                 1255                 1260             


Gln Arg  Ala Pro Glu Gln Leu  Leu Ala Leu Thr Pro  Leu His Gln 
    1265                 1270                 1275             


Ala Ala  Leu Ala Glu Arg Ala  Leu Gln Asn Leu Ala  Pro Lys Glu 
    1280                 1285                 1290             


Thr Pro  Val Ser Gly Glu Val  Leu Glu Thr Leu Gly  Pro Leu Val 
    1295                 1300                 1305             


Gly Phe  Leu Gly Thr Glu Ser  Thr Arg Gln Ile Pro  Leu Gln Ile 
    1310                 1315                 1320             


Leu Leu  Ser His Leu Ser Gln  Leu Gln Gly Phe Cys  Leu Gly Glu 
    1325                 1330                 1335             


Thr Phe  Ala Thr Glu Leu Gly  Trp Leu Leu Leu Gln  Glu Ser Val 
    1340                 1345                 1350             


Leu Gly  Lys Pro Glu Leu Trp  Ser Gln Asp Glu Val  Glu Gln Ala 
    1355                 1360                 1365             


Gly Arg  Leu Val Phe Thr Leu  Ser Thr Glu Ala Ile  Ser Leu Ile 
    1370                 1375                 1380             


Pro Arg  Glu Ala Leu Gly Pro  Glu Thr Leu Glu Arg  Leu Leu Glu 
    1385                 1390                 1395             


Lys Gln  Gln Ser Trp Glu Gln  Ser Arg Val Gly Gln  Leu Cys Arg 
    1400                 1405                 1410             


Glu Pro  Gln Leu Ala Ala Lys  Lys Ala Ala Leu Val  Ala Gly Val 
    1415                 1420                 1425             


Val Arg  Pro Ala Ala Glu Asp  Leu Pro Glu Pro Val  Pro Asn Cys 
    1430                 1435                 1440             


Ala Asp  Val Arg Gly Thr Phe  Pro Ala Ala Trp Ser  Ala Thr Gln 
    1445                 1450                 1455             


Ile Ala  Glu Met Glu Leu Ser  Asp Phe Glu Asp Cys  Leu Thr Leu 
    1460                 1465                 1470             


Phe Ala  Gly Asp Pro Gly Leu  Gly Pro Glu Glu Leu  Arg Ala Ala 
    1475                 1480                 1485             


Met Gly  Lys Ala Lys Gln Leu  Trp Gly Pro Pro Arg  Gly Phe Arg 
    1490                 1495                 1500             


Pro Glu  Gln Ile Leu Gln Leu  Gly Arg Leu Leu Ile  Gly Leu Gly 
    1505                 1510                 1515             


Asp Arg  Glu Leu Gln Glu Leu  Ile Leu Val Asp Trp  Gly Val Leu 
    1520                 1525                 1530             


Ser Thr  Leu Gly Gln Ile Asp  Gly Trp Ser Thr Thr  Gln Leu Arg 
    1535                 1540                 1545             


Ile Val  Val Ser Ser Phe Leu  Arg Gln Ser Gly Arg  His Val Ser 
    1550                 1555                 1560             


His Leu  Asp Phe Val His Leu  Thr Ala Leu Gly Tyr  Thr Leu Cys 
    1565                 1570                 1575             


Gly Leu  Arg Pro Glu Glu Leu  Gln His Ile Ser Ser  Trp Glu Phe 
    1580                 1585                 1590             


Ser Gln  Ala Ala Leu Phe Leu  Gly Thr Leu His Leu  Gln Cys Ser 
    1595                 1600                 1605             


Glu Glu  Gln Leu Glu Val Leu  Ala His Leu Leu Val  Leu Pro Gly 
    1610                 1615                 1620             


Gly Phe  Gly Pro Ile Ser Asn  Trp Gly Pro Glu Ile  Phe Thr Glu 
    1625                 1630                 1635             


Ile Gly  Thr Ile Ala Ala Gly  Ile Pro Asp Leu Ala  Leu Ser Ala 
    1640                 1645                 1650             


Leu Leu  Arg Gly Gln Ile Gln  Gly Val Thr Pro Leu  Ala Ile Ser 
    1655                 1660                 1665             


Val Ile  Pro Pro Pro Lys Phe  Ala Val Val Phe Ser  Pro Ile Gln 
    1670                 1675                 1680             


Leu Ser  Ser Leu Thr Ser Ala  Gln Ala Val Ala Val  Thr Pro Glu 
    1685                 1690                 1695             


Gln Met  Ala Phe Leu Ser Pro  Glu Gln Arg Arg Ala  Val Ala Trp 
    1700                 1705                 1710             


Ala Gln  His Glu Gly Lys Glu  Ser Pro Glu Gln Gln  Gly Arg Ser 
    1715                 1720                 1725             


Thr Ala  Trp Gly Leu Gln Asp  Trp Ser Arg Pro Ser  Trp Ser Leu 
    1730                 1735                 1740             


Val Leu  Thr Ile Ser Phe Leu  Gly His Leu Leu 
    1745                 1750                 


<210> 3
<211> 5361
<212> DNA
<213> Mus musculus

<400> 3
gcccctactg ggcctcagtc tttggatgct ggtctctccc ttctgaagtc attcgtagcc       60

actctggacc aagctcctca gcgttccctc agccagtcac ggttctctgc gttcctggcc      120

aacatttctt catccttcca gcttgggagg atgggggagg gaccggtggg agagccccca      180

cctctccagc cccctgcact tcgacttcat gatttcctcg tgacactgag aggtagccca      240

gactgggagc caatgctagg gcttctggga gatgtgctgg cactcctggg acaggaacag      300

actccccggg actttttggt gcaccaggca ggtgtactgg gtggacttgt agaggcattg      360

ttgggagcgt tagttcctgg aggcccccct gcccccactc gacccccatg cacccgtgat      420

ggcccttctg actgtgtcct ggctgctgat tggttgcctt ctctgatgtt gttattagag      480

ggtacacgct ggcaggccct ggtgcagttg cagcccagtg tggacccaac caatgccaca      540

ggtcttgatg gtagagagcc agctcctcac tttttacagg gtctgctggg cttgcttacc      600

ccagcaggag agttgggctc tgaggaggct ctttggggtg gtctgctgcg cacagtgggg      660

gcccccctct atgctgcctt ccaggagggg ctactgcgag tcactcattc tctgcaagat      720

gaggtctttt ctattatggg acagccagag cctgatgcca gtgggcagtg ccagggaggc      780

aaccttcaac agctgctttt atggggcatg cggaacaacc tttcttggga cgcccgagca      840

ctgggttttc tatctggatc accacctcca ccccctgctc tcctgcactg cctgagcaga      900

ggtgtgcctc tgcccagggc ttcccagcct gcggctcaca tcagccctcg acagcggcga      960

gccatctctg tggaggccct ctgcgagaac cactcaggcc cagagccacc ctacagcatc     1020

tccaacttct ccatctactt gctctgccag cacatcaagc ctgccacccc gcggccccct     1080

cctaccaccc cacggcctcc tcctaccacc ccacagcccc ctcctaccac tacacagccc     1140

attcctgaca ctacacagcc ccctcctgtc accccaaggc ctcctcctac caccccacaa     1200

ccccctccta gcacagctgt catctgccag acagctgtat ggtacgcagt ctcgtgggca     1260

ccaggtgccc gaggttggct ccaagcctgc catgatcagt ttcctgatca atttctggat     1320

atgatctgcg gcaacctctc attttcagcc ctgtctggcc ccagtcgtcc tttggtaaag     1380

cagctctgtg ctggcttgct cccacccccc actagctgtc caccaggcct gatccctgtg     1440

cccctcaccc cagaaatatt ctggggctgt ttcctggaga atgagacact gtgggctgaa     1500

cggttgtgtg tggaggacag tctgcaggct gtgcccccga ggaaccaggc ttgggttcag     1560

catgtgtgtc ggggccccac cttggacgcc actgattttc caccgtgccg cgttggaccc     1620

tgtggggaac gctgcccaga tgggggcagc ttcctgctca tggtctgtgc caatgacact     1680

ctgtatgaag ccttggttcc cttctgggct tggctagcag gccaatgcag aattagtcgt     1740

ggaggaaatg atacttgctt tctagaaggc atgctgggcc ccttgttgcc ctctctgccc     1800

cctctgggac catccccact ctgtctggct cctggtcctt ttctgcttgg catgttatcc     1860

cagttgccac gctgtcagtc ctccgtgcca gccctcgccc accccacgcg cctacattac     1920

ctcctgcgcc tactgacctt ccttctgggt ccagggactg ggggtgccga gacgcagggg     1980

atgttaggtc aagccctgct gctctctagt ctcccagaca actgttcatt ctgggatgcc     2040

ttccgcccag agggccggag aagtgtactg aggacagtcg gagagtactt gcagcgggaa     2100

gagccaaccc caccaggctt agactcctcc ctcagcctcg gctctggtat gagcaagatg     2160

gagcttctgt cctgcttcag tcctgtactg tgggatctac tccagagaga gaagagcgtt     2220

tgggccctga ggaccctggt gaaggcctac ctgcgcatgc ctccagaaga ccttcagcag     2280

cttgtgcttt cagcagagat ggaggctgca cagggcttcc tgacgctcat gcttcgttcc     2340

tgggctaagc tgaaggttca accatccgag gagcaggcca tgggccgcct gacagccttg     2400

ctgctccagc ggtacccacg cctcacctcc caactcttta tcgacatgtc accgctcatc     2460

cccttcctgg ctgtccctga cctcatgcgc ttcccaccgt cccttttggc caacgacagt     2520

gtcctggctg ccatcaggga tcacagctca ggaatgaagc ctgaacagaa ggaggccctg     2580

gcaaaacgac tgctggcccc tgagctgttt ggagaagtgc ctgattggcc ccaggagctg     2640

ctgtgggcag ccctgcctct gcttccccat ctgcctctgg agagctttct ccagctcagc     2700

cctcaccaga tccaggccct ggaggatagc tggccagtag cagatcttgg gccgggacac     2760

gcccgacatg tgcttcgtag cctagtaaac cagagcatgg aggatgggga ggagcaggtg     2820

ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg agctacagag tctggtgccc     2880

ttgagtgatc caatggggcc tgtagaacag ggtctgctgg aatgtgcggc caatgggacc     2940

ctcagcccag aaggacgggt ggcatatgaa cttctgggag tgttgcgttc atctggagga     3000

actgtcttaa gcccccgaga gctgagggtc tgggcacctc tctttcccca gctgggcctc     3060

cgcttcctgc aggagctctc agagacccag cttagagcca tgcttcctgc cctacaggga     3120

gccagtgtca cacctgccca ggctgttctg ttgtttggaa ggctccttcc taagcatgat     3180

ctgtccctgg aggaactctg ctccctgcac cctctcctgc caggtctcag cccccagaca     3240

ctccaggcca tccctaagag agttctggtt ggtgcttgtt cctgcctggg ccctgaactg     3300

tcaaggcttt cagcttgcca gattgcagct ctgctgcaga cctttcgggt aaaagatggt     3360

gttaaaaata tgggtgcagc aggtgccggc tcagccgtgt gcattcctgg gcagcccacc     3420

acttggccag actgcctgct tcccctgctc ccattaaagc tgctacagct ggacgctgca     3480

gctcttctgg caaaccgaag actctatcgg cagctgcctt ggtctgagca acaggcacag     3540

tttctctgga agaaaatgca agtgcctacc aacctgagcc tgaggaatct gcaggctctg     3600

ggcaacttgg caggaggcat gacctgcgag tttctgcagc agatcagctc aatggttgac     3660

tttcttgatg tggtacacat gctctaccag ctgcccactg gtgttcgaga gagcctgcgg     3720

gcctgtatct ggacagagct acagcggagg atgacaatgc cagagccaga gctgaccacc     3780

ctagggccag aactgagtga acttgacaca aagctactcc tggacttgcc gatccagctg     3840

atggacagat tgtccaatga ttccattatg ttggtggtgg agatggtcca aggcgctcca     3900

gagcagctgc tggcactgac cccactccac cagacagcct tggcagagcg agcacttaaa     3960

aacctggctc caaaggagac cccaatctcc aaagaagtgc tggagacact gggccccttg     4020

gttggattcc tgggaataga gagcacgcga cggatccctt tacccattct actgtctcat     4080

ctcagtcagc tgcagggctt ctgcctagga gagacatttg ccacagagct gggatggctg     4140

ctgttgcagg agcctgttct tggaaaacca gaattgtgga gccaggatga aatagagcaa     4200

gctggacgcc tagtattcac tctgtctgct gaggctattt cctcgatccc cagggaggct     4260

ttgggcccag agacactgga gaggcttctg ggaaagcatc aaagctggga gcagagcaga     4320

gtgggccatc tgtgtgggga gtcacagctt gcccacaaga aagcagctct ggtagctggg     4380

attgtgcatc cagctgctga gggtctccaa gagcctgtac caaactgtgc agacatacgg     4440

ggaaccttcc cagcggcctg gtctgcgaca caaatctcag agatggaact ctcagacttt     4500

gaagactgcc tgtcactatt tgctggagat ccaggacttg gtcctgagga actacgggca     4560

gccatgggca aggccaagca gttgtggggt ccccctcgag gattccgtcc tgagcagatc     4620

ttgcagctgg gccgtctcct gataggtcta ggagaacggg aactgcagga gcttaccttg     4680

gtggactggg gtgtgctgag cagcctgggg caaatagatg gctggagttc catgcagctc     4740

cgagccgtgg tctccagttt cctaaggcag agtggtcggc atgtgagcca cctggacttc     4800

atttatctga cagcactggg ttacacagtc tgtggattgc gaccagagga gttacagcac     4860

atcagcagtt gggagtttag ccaagcagct ctcttcctgg gtagcttgca tctcccgtgc     4920

tctgaggaac agctggaagt tctggcctat ctccttgtgt tgcctggtgg ctttggccca     4980

gtcagtaact gggggcctga gatcttcact gaaattggca caatagcagc tggcatccca     5040

gacctggctc tttcagcatt actgcgggga cagatccaag gcctgactcc tcttgccatt     5100

tctgtcattc ctgctcccaa gtttgcagtg gtcttcaacc ccatccagtt atctagtctc     5160

accaggggtc aggccgtagc tgttactcct gaacagctgg cctatctgag tcctgagcag     5220

cggcgagcag ttgcatgggc ccaacacgaa gggaaggaga tcccagagca gctgggtcga     5280

aactcagcct ggggtctcta cgactggttc caagcctcct gggccctggc attgcccgtc     5340

agcatttttg gccacctatt a                                               5361


<210> 4
<211> 1787
<212> PRT
<213> Mus musculus

<400> 4
Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala Gly Leu Ser Leu Leu Lys 
1               5                   10                  15      


Ser Phe Val Ala Thr Leu Asp Gln Ala Pro Gln Arg Ser Leu Ser Gln 
            20                  25                  30          


Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile Ser Ser Ser Phe Gln Leu 
        35                  40                  45              


Gly Arg Met Gly Glu Gly Pro Val Gly Glu Pro Pro Pro Leu Gln Pro 
    50                  55                  60                  


Pro Ala Leu Arg Leu His Asp Phe Leu Val Thr Leu Arg Gly Ser Pro 
65                  70                  75                  80  


Asp Trp Glu Pro Met Leu Gly Leu Leu Gly Asp Val Leu Ala Leu Leu 
                85                  90                  95      


Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu Val His Gln Ala Gly Val 
            100                 105                 110         


Leu Gly Gly Leu Val Glu Ala Leu Leu Gly Ala Leu Val Pro Gly Gly 
        115                 120                 125             


Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr Arg Asp Gly Pro Ser Asp 
    130                 135                 140                 


Cys Val Leu Ala Ala Asp Trp Leu Pro Ser Leu Met Leu Leu Leu Glu 
145                 150                 155                 160 


Gly Thr Arg Trp Gln Ala Leu Val Gln Leu Gln Pro Ser Val Asp Pro 
                165                 170                 175     


Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu Pro Ala Pro His Phe Leu 
            180                 185                 190         


Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala Gly Glu Leu Gly Ser Glu 
        195                 200                 205             


Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr Val Gly Ala Pro Leu Tyr 
    210                 215                 220                 


Ala Ala Phe Gln Glu Gly Leu Leu Arg Val Thr His Ser Leu Gln Asp 
225                 230                 235                 240 


Glu Val Phe Ser Ile Met Gly Gln Pro Glu Pro Asp Ala Ser Gly Gln 
                245                 250                 255     


Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu Leu Trp Gly Met Arg Asn 
            260                 265                 270         


Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly Phe Leu Ser Gly Ser Pro 
        275                 280                 285             


Pro Pro Pro Pro Ala Leu Leu His Cys Leu Ser Arg Gly Val Pro Leu 
    290                 295                 300                 


Pro Arg Ala Ser Gln Pro Ala Ala His Ile Ser Pro Arg Gln Arg Arg 
305                 310                 315                 320 


Ala Ile Ser Val Glu Ala Leu Cys Glu Asn His Ser Gly Pro Glu Pro 
                325                 330                 335     


Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr Leu Leu Cys Gln His Ile 
            340                 345                 350         


Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr Thr Pro Arg Pro Pro Pro 
        355                 360                 365             


Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr Gln Pro Ile Pro Asp Thr 
    370                 375                 380                 


Thr Gln Pro Pro Pro Val Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln 
385                 390                 395                 400 


Pro Pro Pro Ser Thr Ala Val Ile Cys Gln Thr Ala Val Trp Tyr Ala 
                405                 410                 415     


Val Ser Trp Ala Pro Gly Ala Arg Gly Trp Leu Gln Ala Cys His Asp 
            420                 425                 430         


Gln Phe Pro Asp Gln Phe Leu Asp Met Ile Cys Gly Asn Leu Ser Phe 
        435                 440                 445             


Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu Val Lys Gln Leu Cys Ala 
    450                 455                 460                 


Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro Pro Gly Leu Ile Pro Val 
465                 470                 475                 480 


Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr 
                485                 490                 495     


Leu Trp Ala Glu Arg Leu Cys Val Glu Asp Ser Leu Gln Ala Val Pro 
            500                 505                 510         


Pro Arg Asn Gln Ala Trp Val Gln His Val Cys Arg Gly Pro Thr Leu 
        515                 520                 525             


Asp Ala Thr Asp Phe Pro Pro Cys Arg Val Gly Pro Cys Gly Glu Arg 
    530                 535                 540                 


Cys Pro Asp Gly Gly Ser Phe Leu Leu Met Val Cys Ala Asn Asp Thr 
545                 550                 555                 560 


Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala Trp Leu Ala Gly Gln Cys 
                565                 570                 575     


Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Met Leu 
            580                 585                 590         


Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys 
        595                 600                 605             


Leu Ala Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg 
    610                 615                 620                 


Cys Gln Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr 
625                 630                 635                 640 


Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Thr Gly Gly Ala 
                645                 650                 655     


Glu Thr Gln Gly Met Leu Gly Gln Ala Leu Leu Leu Ser Ser Leu Pro 
            660                 665                 670         


Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser 
        675                 680                 685             


Val Leu Arg Thr Val Gly Glu Tyr Leu Gln Arg Glu Glu Pro Thr Pro 
    690                 695                 700                 


Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly Ser Gly Met Ser Lys Met 
705                 710                 715                 720 


Glu Leu Leu Ser Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 
                725                 730                 735     


Glu Lys Ser Val Trp Ala Leu Arg Thr Leu Val Lys Ala Tyr Leu Arg 
            740                 745                 750         


Met Pro Pro Glu Asp Leu Gln Gln Leu Val Leu Ser Ala Glu Met Glu 
        755                 760                 765             


Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Arg Ser Trp Ala Lys Leu 
    770                 775                 780                 


Lys Val Gln Pro Ser Glu Glu Gln Ala Met Gly Arg Leu Thr Ala Leu 
785                 790                 795                 800 


Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile Asp Met 
                805                 810                 815     


Ser Pro Leu Ile Pro Phe Leu Ala Val Pro Asp Leu Met Arg Phe Pro 
            820                 825                 830         


Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg Asp His 
        835                 840                 845             


Ser Ser Gly Met Lys Pro Glu Gln Lys Glu Ala Leu Ala Lys Arg Leu 
    850                 855                 860                 


Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Asp Trp Pro Gln Glu Leu 
865                 870                 875                 880 


Leu Trp Ala Ala Leu Pro Leu Leu Pro His Leu Pro Leu Glu Ser Phe 
                885                 890                 895     


Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser Trp Pro 
            900                 905                 910         


Val Ala Asp Leu Gly Pro Gly His Ala Arg His Val Leu Arg Ser Leu 
        915                 920                 925             


Val Asn Gln Ser Met Glu Asp Gly Glu Glu Gln Val Leu Arg Leu Gly 
    930                 935                 940                 


Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu Val Pro 
945                 950                 955                 960 


Leu Ser Asp Pro Met Gly Pro Val Glu Gln Gly Leu Leu Glu Cys Ala 
                965                 970                 975     


Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu Leu Leu 
            980                 985                 990         


Gly Val Leu Arg Ser Ser Gly Gly  Thr Val Leu Ser Pro  Arg Glu Leu 
        995                 1000                 1005             


Arg Val  Trp Ala Pro Leu Phe  Pro Gln Leu Gly Leu  Arg Phe Leu 
    1010                 1015                 1020             


Gln Glu  Leu Ser Glu Thr Gln  Leu Arg Ala Met Leu  Pro Ala Leu 
    1025                 1030                 1035             


Gln Gly  Ala Ser Val Thr Pro  Ala Gln Ala Val Leu  Leu Phe Gly 
    1040                 1045                 1050             


Arg Leu  Leu Pro Lys His Asp  Leu Ser Leu Glu Glu  Leu Cys Ser 
    1055                 1060                 1065             


Leu His  Pro Leu Leu Pro Gly  Leu Ser Pro Gln Thr  Leu Gln Ala 
    1070                 1075                 1080             


Ile Pro  Lys Arg Val Leu Val  Gly Ala Cys Ser Cys  Leu Gly Pro 
    1085                 1090                 1095             


Glu Leu  Ser Arg Leu Ser Ala  Cys Gln Ile Ala Ala  Leu Leu Gln 
    1100                 1105                 1110             


Thr Phe  Arg Val Lys Asp Gly  Val Lys Asn Met Gly  Ala Ala Gly 
    1115                 1120                 1125             


Ala Gly  Ser Ala Val Cys Ile  Pro Gly Gln Pro Thr  Thr Trp Pro 
    1130                 1135                 1140             


Asp Cys  Leu Leu Pro Leu Leu  Pro Leu Lys Leu Leu  Gln Leu Asp 
    1145                 1150                 1155             


Ala Ala  Ala Leu Leu Ala Asn  Arg Arg Leu Tyr Arg  Gln Leu Pro 
    1160                 1165                 1170             


Trp Ser  Glu Gln Gln Ala Gln  Phe Leu Trp Lys Lys  Met Gln Val 
    1175                 1180                 1185             


Pro Thr  Asn Leu Ser Leu Arg  Asn Leu Gln Ala Leu  Gly Asn Leu 
    1190                 1195                 1200             


Ala Gly  Gly Met Thr Cys Glu  Phe Leu Gln Gln Ile  Ser Ser Met 
    1205                 1210                 1215             


Val Asp  Phe Leu Asp Val Val  His Met Leu Tyr Gln  Leu Pro Thr 
    1220                 1225                 1230             


Gly Val  Arg Glu Ser Leu Arg  Ala Cys Ile Trp Thr  Glu Leu Gln 
    1235                 1240                 1245             


Arg Arg  Met Thr Met Pro Glu  Pro Glu Leu Thr Thr  Leu Gly Pro 
    1250                 1255                 1260             


Glu Leu  Ser Glu Leu Asp Thr  Lys Leu Leu Leu Asp  Leu Pro Ile 
    1265                 1270                 1275             


Gln Leu  Met Asp Arg Leu Ser  Asn Asp Ser Ile Met  Leu Val Val 
    1280                 1285                 1290             


Glu Met  Val Gln Gly Ala Pro  Glu Gln Leu Leu Ala  Leu Thr Pro 
    1295                 1300                 1305             


Leu His  Gln Thr Ala Leu Ala  Glu Arg Ala Leu Lys  Asn Leu Ala 
    1310                 1315                 1320             


Pro Lys  Glu Thr Pro Ile Ser  Lys Glu Val Leu Glu  Thr Leu Gly 
    1325                 1330                 1335             


Pro Leu  Val Gly Phe Leu Gly  Ile Glu Ser Thr Arg  Arg Ile Pro 
    1340                 1345                 1350             


Leu Pro  Ile Leu Leu Ser His  Leu Ser Gln Leu Gln  Gly Phe Cys 
    1355                 1360                 1365             


Leu Gly  Glu Thr Phe Ala Thr  Glu Leu Gly Trp Leu  Leu Leu Gln 
    1370                 1375                 1380             


Glu Pro  Val Leu Gly Lys Pro  Glu Leu Trp Ser Gln  Asp Glu Ile 
    1385                 1390                 1395             


Glu Gln  Ala Gly Arg Leu Val  Phe Thr Leu Ser Ala  Glu Ala Ile 
    1400                 1405                 1410             


Ser Ser  Ile Pro Arg Glu Ala  Leu Gly Pro Glu Thr  Leu Glu Arg 
    1415                 1420                 1425             


Leu Leu  Gly Lys His Gln Ser  Trp Glu Gln Ser Arg  Val Gly His 
    1430                 1435                 1440             


Leu Cys  Gly Glu Ser Gln Leu  Ala His Lys Lys Ala  Ala Leu Val 
    1445                 1450                 1455             


Ala Gly  Ile Val His Pro Ala  Ala Glu Gly Leu Gln  Glu Pro Val 
    1460                 1465                 1470             


Pro Asn  Cys Ala Asp Ile Arg  Gly Thr Phe Pro Ala  Ala Trp Ser 
    1475                 1480                 1485             


Ala Thr  Gln Ile Ser Glu Met  Glu Leu Ser Asp Phe  Glu Asp Cys 
    1490                 1495                 1500             


Leu Ser  Leu Phe Ala Gly Asp  Pro Gly Leu Gly Pro  Glu Glu Leu 
    1505                 1510                 1515             


Arg Ala  Ala Met Gly Lys Ala  Lys Gln Leu Trp Gly  Pro Pro Arg 
    1520                 1525                 1530             


Gly Phe  Arg Pro Glu Gln Ile  Leu Gln Leu Gly Arg  Leu Leu Ile 
    1535                 1540                 1545             


Gly Leu  Gly Glu Arg Glu Leu  Gln Glu Leu Thr Leu  Val Asp Trp 
    1550                 1555                 1560             


Gly Val  Leu Ser Ser Leu Gly  Gln Ile Asp Gly Trp  Ser Ser Met 
    1565                 1570                 1575             


Gln Leu  Arg Ala Val Val Ser  Ser Phe Leu Arg Gln  Ser Gly Arg 
    1580                 1585                 1590             


His Val  Ser His Leu Asp Phe  Ile Tyr Leu Thr Ala  Leu Gly Tyr 
    1595                 1600                 1605             


Thr Val  Cys Gly Leu Arg Pro  Glu Glu Leu Gln His  Ile Ser Ser 
    1610                 1615                 1620             


Trp Glu  Phe Ser Gln Ala Ala  Leu Phe Leu Gly Ser  Leu His Leu 
    1625                 1630                 1635             


Pro Cys  Ser Glu Glu Gln Leu  Glu Val Leu Ala Tyr  Leu Leu Val 
    1640                 1645                 1650             


Leu Pro  Gly Gly Phe Gly Pro  Val Ser Asn Trp Gly  Pro Glu Ile 
    1655                 1660                 1665             


Phe Thr  Glu Ile Gly Thr Ile  Ala Ala Gly Ile Pro  Asp Leu Ala 
    1670                 1675                 1680             


Leu Ser  Ala Leu Leu Arg Gly  Gln Ile Gln Gly Leu  Thr Pro Leu 
    1685                 1690                 1695             


Ala Ile  Ser Val Ile Pro Ala  Pro Lys Phe Ala Val  Val Phe Asn 
    1700                 1705                 1710             


Pro Ile  Gln Leu Ser Ser Leu  Thr Arg Gly Gln Ala  Val Ala Val 
    1715                 1720                 1725             


Thr Pro  Glu Gln Leu Ala Tyr  Leu Ser Pro Glu Gln  Arg Arg Ala 
    1730                 1735                 1740             


Val Ala  Trp Ala Gln His Glu  Gly Lys Glu Ile Pro  Glu Gln Leu 
    1745                 1750                 1755             


Gly Arg  Asn Ser Ala Trp Gly  Leu Tyr Asp Trp Phe  Gln Ala Ser 
    1760                 1765                 1770             


Trp Ala  Leu Ala Leu Pro Val  Ser Ile Phe Gly His  Leu Leu 
    1775                 1780                 1785         


<210> 5
<211> 2436
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gcagtgactc tggcccctac tgggcctcat tccctggacc ctggtctctc cttcctgaag      120

tcattgctct ccactctgga ccaggctccc cagggctccc tgagccgctc acggttcttt      180

acattcctgg ccaacatttc ttcttccttt gagcctggga gaatggggga aggaccagta      240

ggagagcccc cacctctcca gccgcctgct ctgcggctcc atgattttct agtgacactg      300

agaggtagcc ccgactggga gccaatgcta gggctgctag gggatatgct ggcactgctg      360

ggacaggagc agactccccg agatttcctg gtgcaccagg caggggtgct gggtggactt      420

gtggaggtgc tgctgggagc cttagttcct gggggccccc ctaccccaac tcggccccca      480

tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg actggttgcc ttctctgctg      540

ctgttgttag agggcacacg ctggcaagct ctggtgcagg tgcagcccag tgtggacccc      600

accaatgcca caggcctcga tgggagggag gcagctcctc actttttgca gggtctgttg      660

ggtttgctta ccccaacagg ggagctaggc tccaaggagg ctctttgggg cggtctgcta      720

cgcacagtgg gggcccccct ctatgctgcc tttcaggagg ggctgctccg tgtcactcac      780

tccctgcagg atgaggtctt ctccattttg gggcagccag agcctgatac caatgggcag      840

tgccagggag gtaaccttca acagctgctc ttatggggcg tccggcacaa cctttcctgg      900

gatgtccagg cgctgggctt tctgtctgga tcaccacccc caccccctgc cctccttcac      960

tgcctgagca cgggcgtgcc tctgcccaga gcttctcagc cgtcagccca catcagccca     1020

cgccaacggc gagccatcac tgtggaggcc ctctgtgaga accacttagg cccagcacca     1080

ccctacagca tttccaactt ctccatccac ttgctctgcc agcacaccaa gcctgccact     1140

ccacagcccc atcccagcac cactgccatc tgccagacag ctgtgtggta tgcagtgtcc     1200

tgggcaccag gtgcccaagg ctggctacag gcctgccacg accagtttcc tgatgagttt     1260

ttggatgcga tctgcagtaa cctctccttt tcagccctgt ctggctccaa ccgccgcctg     1320

gtgaagcggc tctgtgctgg cctgctccca ccccctacca gctgccctga aggcctgccc     1380

cctgttcccc tcaccccaga catcttttgg ggctgcttct tggagaatga gactctgtgg     1440

gctgagcgac tgtgtgggga ggcaagtcta caggctgtgc cccccagcaa ccaggcttgg     1500

gtccagcatg tgtgccaggg ccccacccca gatgtcactg cctccccacc atgccacatt     1560

ggaccctgtg gggaacgctg cccggatggg ggcagcttcc tggtgatggt ctgtgccaat     1620

gacaccatgt atgaggtcct ggtgcccttc tggccttggc tagcaggcca atgcaggata     1680

agtcgtgggg gcaatgacac ttgcttccta gaagggctgc tgggccccct tctgccctct     1740

ctgccaccac tgggaccatc cccactctgt ctgacccctg gccccttcct ccttggcatg     1800

ctatcccagt tgccacgctg tcagtcctct gtcccagctc ttgctcaccc cacacgccta     1860

cactatctcc tccgcctgct gaccttcctc ttgggtccag gggctggggg cgctgaggcc     1920

caggggatgc tgggtcgggc cctactgctc tccagtctcc cagacaactg ctccttctgg     1980

gatgcctttc gcccagaggg ccggcgcagt gtgctacgga cgattgggga atacctggaa     2040

caagatgagg agcagccaac cccatcaggc tttgaaccca ctgtcaaccc cagctctggt     2100

ataagcaaga tggagctgct ggcctgcctg tcatacgaaa ccgagatact gacagtagaa     2160

tatggccttc tgccaatcgg gaagattgtg gagaaacgga tagaatgcac agtttactct     2220

gtcgataaca atggtaacat ttatactcag ccagttgccc agtggcacga ccggggagag     2280

caggaagtat tcgaatactg tctggaggat ggaagtctca ttagggccac taaggaccac     2340

aaatttatga cagtcgatgg ccagatgctg cctatagacg aaatctttga gcgagagttg     2400

gacctcatgc gagttgacaa ccttcctaat taatag                               2436


<210> 6
<211> 810
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 
            20                  25                  30          


Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 
        35                  40                  45              


Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 
    50                  55                  60                  


Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 
65                  70                  75                  80  


Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 
                85                  90                  95      


Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 
            100                 105                 110         


Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 
        115                 120                 125             


Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 
    130                 135                 140                 


Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 
                165                 170                 175     


Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 
            180                 185                 190         


Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 
        195                 200                 205             


Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 
225                 230                 235                 240 


Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 
                245                 250                 255     


Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 
            260                 265                 270         


Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 
        275                 280                 285             


Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 
    290                 295                 300                 


Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 
305                 310                 315                 320 


Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 
                325                 330                 335     


His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 
            340                 345                 350         


Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 
        355                 360                 365             


Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 
    370                 375                 380                 


Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 
385                 390                 395                 400 


Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 
                405                 410                 415     


Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 
            420                 425                 430         


Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 
        435                 440                 445             


Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 
    450                 455                 460                 


Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 
465                 470                 475                 480 


Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 
                485                 490                 495     


Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 
            500                 505                 510         


Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 
        515                 520                 525             


Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 
    530                 535                 540                 


Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 
545                 550                 555                 560 


Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 
                565                 570                 575     


Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 
            580                 585                 590         


Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 
        595                 600                 605             


Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 
    610                 615                 620                 


Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 
625                 630                 635                 640 


Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 
                645                 650                 655     


Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 
            660                 665                 670         


Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 
        675                 680                 685             


Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 
    690                 695                 700                 


Glu Leu Leu Ala Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu 
705                 710                 715                 720 


Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys 
                725                 730                 735     


Thr Val Tyr Ser Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val 
            740                 745                 750         


Ala Gln Trp His Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu 
        755                 760                 765             


Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr 
    770                 775                 780                 


Val Asp Gly Gln Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu 
785                 790                 795                 800 


Asp Leu Met Arg Val Asp Asn Leu Pro Asn 
                805                 810 


<210> 7
<211> 2550
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc      120

gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc      180

ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag      240

cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt      300

agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag      360

gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag      420

gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc      480

cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta      540

ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat      600

gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg      660

cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca      720

gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg      780

caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag      840

ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc      900

cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg      960

agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag     1020

cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac     1080

agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg     1140

ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca     1200

cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc     1260

ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg     1320

tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt     1380

ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg     1440

gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc     1500

cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg     1560

gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg     1620

gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt     1680

ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat     1740

gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt     1800

agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct     1860

ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg     1920

ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta     1980

cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg     2040

caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg     2100

gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag     2160

cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc     2220

aagatggagc ttctgtcctg cctgtcatac gaaaccgaga tactgacagt agaatatggc     2280

cttctgccaa tcgggaagat tgtggagaaa cggatagaat gcacagttta ctctgtcgat     2340

aacaatggta acatttatac tcagccagtt gcccagtggc acgaccgggg agagcaggaa     2400

gtattcgaat actgtctgga ggatggaagt ctcattaggg ccactaagga ccacaaattt     2460

atgacagtcg atggccagat gctgcctata gacgaaatct ttgagcgaga gttggacctc     2520

atgcgagttg acaaccttcc taattaatag                                      2550


<210> 8
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 
            20                  25                  30          


Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 
        35                  40                  45              


Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 
    50                  55                  60                  


Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 
65                  70                  75                  80  


Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 
                85                  90                  95      


Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 
            100                 105                 110         


Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 
        115                 120                 125             


Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 
    130                 135                 140                 


Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 
145                 150                 155                 160 


Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 
                165                 170                 175     


Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 
            180                 185                 190         


Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 
        195                 200                 205             


Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 
    210                 215                 220                 


Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 
225                 230                 235                 240 


Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 
                245                 250                 255     


Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 
            260                 265                 270         


Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 
        275                 280                 285             


Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 
    290                 295                 300                 


Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 
305                 310                 315                 320 


Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 
                325                 330                 335     


Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 
            340                 345                 350         


His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 
        355                 360                 365             


Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 
    370                 375                 380                 


Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 
                405                 410                 415     


Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 
            420                 425                 430         


Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 
        435                 440                 445             


Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 
    450                 455                 460                 


Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 
465                 470                 475                 480 


Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 
                485                 490                 495     


Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 
            500                 505                 510         


Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 
        515                 520                 525             


Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 
    530                 535                 540                 


Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 
545                 550                 555                 560 


Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 
                565                 570                 575     


Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 
            580                 585                 590         


Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 
        595                 600                 605             


Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 
    610                 615                 620                 


Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 
625                 630                 635                 640 


Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 
                645                 650                 655     


Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 
            660                 665                 670         


Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 
        675                 680                 685             


Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 
    690                 695                 700                 


Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 
705                 710                 715                 720 


Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 
                725                 730                 735     


Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Leu Ser Tyr Glu Thr 
            740                 745                 750         


Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val 
        755                 760                 765             


Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser Val Asp Asn Asn Gly Asn 
    770                 775                 780                 


Ile Tyr Thr Gln Pro Val Ala Gln Trp His Asp Arg Gly Glu Gln Glu 
785                 790                 795                 800 


Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser Leu Ile Arg Ala Thr Lys 
                805                 810                 815     


Asp His Lys Phe Met Thr Val Asp Gly Gln Met Leu Pro Ile Asp Glu 
            820                 825                 830         


Ile Phe Glu Arg Glu Leu Asp Leu Met Arg Val Asp Asn Leu Pro Asn 
        835                 840                 845             


<210> 9
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gctctcagcc tctggcccct gctgctgctg ctgctgctgc tgctgctgct gtcctttgca       60


<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Phe Ala 
            20  


<210> 11
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gctctgagcc tccagcccca gctgctcctt ctcctgtcgc tcctgccgca ggaagtgact       60

tca                                                                     63


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu Pro 
1               5                   10                  15      


Gln Glu Val Thr Ser 
            20      


<210> 13
<211> 306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
tgcctgtcat acgaaaccga gatactgaca gtagaatatg gccttctgcc aatcgggaag       60

attgtggaga aacggataga atgcacagtt tactctgtcg ataacaatgg taacatttat      120

actcagccag ttgcccagtg gcacgaccgg ggagagcagg aagtattcga atactgtctg      180

gaggatggaa gtctcattag ggccactaag gaccacaaat ttatgacagt cgatggccag      240

atgctgccta tagacgaaat ctttgagcga gagttggacc tcatgcgagt tgacaacctt      300

cctaat                                                                 306


<210> 14
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210> 15
<211> 687
<212> PRT
<213> Homo sapiens

<400> 15
Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu Asp Pro Gly Leu Ser 
1               5                   10                  15      


Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln Ala Pro Gln Gly Ser 
            20                  25                  30          


Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala Asn Ile Ser Ser Ser 
        35                  40                  45              


Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val Gly Glu Pro Pro Pro 
    50                  55                  60                  


Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val Thr Leu Arg 
65                  70                  75                  80  


Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly Asp Met Leu 
                85                  90                  95      


Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu Val His Gln 
            100                 105                 110         


Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu Leu Gly Ala Leu Val 
        115                 120                 125             


Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro Cys Thr Arg Asp Gly 
    130                 135                 140                 


Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Val Gln Pro Ser 
                165                 170                 175     


Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu Ala Ala Pro 
            180                 185                 190         


His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Thr Gly Glu Leu 
        195                 200                 205             


Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr Val Gly Ala 
    210                 215                 220                 


Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val Thr His Ser 
225                 230                 235                 240 


Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln Pro Glu Pro Asp Thr 
                245                 250                 255     


Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu Leu Trp Gly 
            260                 265                 270         


Val Arg His Asn Leu Ser Trp Asp Val Gln Ala Leu Gly Phe Leu Ser 
        275                 280                 285             


Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu Ser Thr Gly 
    290                 295                 300                 


Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala His Ile Ser Pro Arg 
305                 310                 315                 320 


Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys Glu Asn His Leu Gly 
                325                 330                 335     


Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile His Leu Leu Cys 
            340                 345                 350         


Gln His Thr Lys Pro Ala Thr Pro Gln Pro His Pro Ser Thr Thr Ala 
        355                 360                 365             


Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala 
    370                 375                 380                 


Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe Pro Asp Glu Phe Leu 
385                 390                 395                 400 


Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala Leu Ser Gly Ser Asn 
                405                 410                 415     


Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr 
            420                 425                 430         


Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu Thr Pro Asp Ile Phe 
        435                 440                 445             


Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys 
    450                 455                 460                 


Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser Asn Gln Ala Trp Val 
465                 470                 475                 480 


Gln His Val Cys Gln Gly Pro Thr Pro Asp Val Thr Ala Ser Pro Pro 
                485                 490                 495     


Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe 
            500                 505                 510         


Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr Glu Val Leu Val Pro 
        515                 520                 525             


Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn 
    530                 535                 540                 


Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro Leu Leu Pro Ser Leu 
545                 550                 555                 560 


Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr Pro Gly Pro Phe Leu 
                565                 570                 575     


Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala 
            580                 585                 590         


Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe 
        595                 600                 605             


Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala Gln Gly Met Leu Gly 
    610                 615                 620                 


Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp 
625                 630                 635                 640 


Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Ile Gly Glu 
                645                 650                 655     


Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro Ser Gly Phe Glu Pro 
            660                 665                 670         


Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met Glu Leu Leu Ala 
        675                 680                 685         


<210> 16
<211> 724
<212> PRT
<213> Mus musculus

<400> 16
Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala Gly Leu Ser Leu Leu Lys 
1               5                   10                  15      


Ser Phe Val Ala Thr Leu Asp Gln Ala Pro Gln Arg Ser Leu Ser Gln 
            20                  25                  30          


Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile Ser Ser Ser Phe Gln Leu 
        35                  40                  45              


Gly Arg Met Gly Glu Gly Pro Val Gly Glu Pro Pro Pro Leu Gln Pro 
    50                  55                  60                  


Pro Ala Leu Arg Leu His Asp Phe Leu Val Thr Leu Arg Gly Ser Pro 
65                  70                  75                  80  


Asp Trp Glu Pro Met Leu Gly Leu Leu Gly Asp Val Leu Ala Leu Leu 
                85                  90                  95      


Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu Val His Gln Ala Gly Val 
            100                 105                 110         


Leu Gly Gly Leu Val Glu Ala Leu Leu Gly Ala Leu Val Pro Gly Gly 
        115                 120                 125             


Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr Arg Asp Gly Pro Ser Asp 
    130                 135                 140                 


Cys Val Leu Ala Ala Asp Trp Leu Pro Ser Leu Met Leu Leu Leu Glu 
145                 150                 155                 160 


Gly Thr Arg Trp Gln Ala Leu Val Gln Leu Gln Pro Ser Val Asp Pro 
                165                 170                 175     


Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu Pro Ala Pro His Phe Leu 
            180                 185                 190         


Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala Gly Glu Leu Gly Ser Glu 
        195                 200                 205             


Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr Val Gly Ala Pro Leu Tyr 
    210                 215                 220                 


Ala Ala Phe Gln Glu Gly Leu Leu Arg Val Thr His Ser Leu Gln Asp 
225                 230                 235                 240 


Glu Val Phe Ser Ile Met Gly Gln Pro Glu Pro Asp Ala Ser Gly Gln 
                245                 250                 255     


Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu Leu Trp Gly Met Arg Asn 
            260                 265                 270         


Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly Phe Leu Ser Gly Ser Pro 
        275                 280                 285             


Pro Pro Pro Pro Ala Leu Leu His Cys Leu Ser Arg Gly Val Pro Leu 
    290                 295                 300                 


Pro Arg Ala Ser Gln Pro Ala Ala His Ile Ser Pro Arg Gln Arg Arg 
305                 310                 315                 320 


Ala Ile Ser Val Glu Ala Leu Cys Glu Asn His Ser Gly Pro Glu Pro 
                325                 330                 335     


Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr Leu Leu Cys Gln His Ile 
            340                 345                 350         


Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr Thr Pro Arg Pro Pro Pro 
        355                 360                 365             


Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr Gln Pro Ile Pro Asp Thr 
    370                 375                 380                 


Thr Gln Pro Pro Pro Val Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln 
385                 390                 395                 400 


Pro Pro Pro Ser Thr Ala Val Ile Cys Gln Thr Ala Val Trp Tyr Ala 
                405                 410                 415     


Val Ser Trp Ala Pro Gly Ala Arg Gly Trp Leu Gln Ala Cys His Asp 
            420                 425                 430         


Gln Phe Pro Asp Gln Phe Leu Asp Met Ile Cys Gly Asn Leu Ser Phe 
        435                 440                 445             


Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu Val Lys Gln Leu Cys Ala 
    450                 455                 460                 


Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro Pro Gly Leu Ile Pro Val 
465                 470                 475                 480 


Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr 
                485                 490                 495     


Leu Trp Ala Glu Arg Leu Cys Val Glu Asp Ser Leu Gln Ala Val Pro 
            500                 505                 510         


Pro Arg Asn Gln Ala Trp Val Gln His Val Cys Arg Gly Pro Thr Leu 
        515                 520                 525             


Asp Ala Thr Asp Phe Pro Pro Cys Arg Val Gly Pro Cys Gly Glu Arg 
    530                 535                 540                 


Cys Pro Asp Gly Gly Ser Phe Leu Leu Met Val Cys Ala Asn Asp Thr 
545                 550                 555                 560 


Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala Trp Leu Ala Gly Gln Cys 
                565                 570                 575     


Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Met Leu 
            580                 585                 590         


Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys 
        595                 600                 605             


Leu Ala Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg 
    610                 615                 620                 


Cys Gln Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr 
625                 630                 635                 640 


Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Thr Gly Gly Ala 
                645                 650                 655     


Glu Thr Gln Gly Met Leu Gly Gln Ala Leu Leu Leu Ser Ser Leu Pro 
            660                 665                 670         


Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser 
        675                 680                 685             


Val Leu Arg Thr Val Gly Glu Tyr Leu Gln Arg Glu Glu Pro Thr Pro 
    690                 695                 700                 


Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly Ser Gly Met Ser Lys Met 
705                 710                 715                 720 


Glu Leu Leu Ser 
                


<210> 17
<211> 3423
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gcaatcaaga tagctacaag gaagtatctt ggcaaacaaa acgtttatga tattggagtc      120

gaaagagatc acaactttgc tctgaagaac ggattcatag cttctaattg ctttagtcct      180

gtgctgtggg atctgctcca gagggaaaag agtgtttggg ccctgcagat tctagtgcag      240

gcgtacctgc atatgccccc agaaaacctc cagcagctgg tgctttcagc agagagggag      300

gctgcacagg gcttcctgac actcatgctg caggggaagc tgcaggggaa gctgcaggta      360

ccaccatccg aggagcaggc cctgggtcgc ctgacagccc tgctgctcca gcggtaccca      420

cgcctcacct cccagctctt cattgacctg tcaccactca tccctttctt ggctgtctct      480

gacctgatgc gcttcccacc atccctgtta gccaacgaca gtgtcctggc tgccatccgg      540

gattacagcc caggaatgag gcctgaacag aaggaggctc tggcaaagcg actgctggcc      600

cctgaactgt ttggggaagt gcctgcctgg ccccaggagc tgctgtgggc agtgctgccc      660

ctgctccccc acctccctct ggagaacttt ttgcagctca gccctcacca gatccaggcc      720

ctggaggata gctggccagc agcaggtctg gggccagggc atgcccgcca tgtgctgcgc      780

agcctggtaa accagagtgt ccaggatggt gaggagcagg tacgcaggct tgggcccctc      840

gcctgtttcc tgagccctga ggagctgcag agcctagtgc ccctgagtga tccaacgggg      900

ccagtagaac gggggctgct ggaatgtgca gccaatggga ccctcagccc agaaggacgg      960

gtggcatatg aacttctggg tgtgttgcgc tcatctggag gagcggtgct gagcccccgg     1020

gagctgcggg tctgggcccc tctcttctct cagctgggcc tccgcttcct tcaggagctg     1080

tcagagcccc agcttagagc catgcttcct gtcctgcagg gaactagtgt tacacctgct     1140

caggctgtcc tgctgcttgg acggctcctt cctaggcacg atctatccct ggaggaactc     1200

tgctccttgc accttctgct accaggcctc agcccccaga cactccaggc catccctagg     1260

cgagtcctgg tcggggcttg ttcctgcctg gcccctgaac tgtcacgcct ctcagcctgc     1320

cagaccgcag cactgctgca gacctttcgg gttaaagatg gtgttaaaaa tatgggtaca     1380

acaggtgctg gtccagctgt gtgtatccct ggtcagccta ttcccaccac ctggccagac     1440

tgcctgcttc ccctgctccc attaaagctg ctacaactgg attccttggc tcttctggca     1500

aatcgaagac gctactggga gctgccctgg tctgagcagc aggcacagtt tctctggaag     1560

aagatgcaag tacccaccaa ccttaccctc aggaatctgc aggctctggg caccctggca     1620

ggaggcatgt cctgtgagtt tctgcagcag atcaactcca tggtagactt ccttgaagtg     1680

gtgcacatga tctatcagct gcccactaga gttcgaggga gcctgagggc ctgtatctgg     1740

gcagagctac agcggaggat ggcaatgcca gaaccagaat ggacaactgt agggccagaa     1800

ctgaacgggc tggatagcaa gctactcctg gacttaccga tccagttgat ggacagacta     1860

tccaatgaat ccattatgtt ggtggtggag ctggtgcaaa gagctccaga gcagctgctg     1920

gcactgaccc ccctccacca ggcagccctg gcagagaggg cactacaaaa cctggctcca     1980

aaggagactc cagtctcagg ggaagtgctg gagaccttag gccctttggt tggattcctg     2040

gggacagaga gcacacgaca gatcccccta cagatcctgc tgtcccatct cagtcagctg     2100

caaggcttct gcctaggaga gacatttgcc acagagctgg gatggctgct attgcaggag     2160

tctgttcttg ggaaaccaga gttgtggagc caggatgaag tagagcaagc tggacgccta     2220

gtattcactc tgtctactga ggcaatttcc ttgatcccca gggaggcctt gggtccagag     2280

accctggagc ggcttctaga aaagcagcag agctgggagc agagcagagt tggacagctg     2340

tgtagggagc cacagcttgc tgccaagaaa gcagccctgg tagcaggggt ggtgcgacca     2400

gctgctgagg atcttccaga acctgtgcca aattgtgcag atgtacgagg gacattccca     2460

gcagcctggt ctgcaaccca gattgcagag atggagctct cagactttga ggactgcctg     2520

acattatttg caggagaccc aggacttggg cctgaggaac tgcgggcagc catgggcaaa     2580

gcaaaacagt tgtggggtcc cccccgggga tttcgtcctg agcagatcct gcagcttggt     2640

aggctcttaa taggtctagg agatcgggaa ctacaggagc tgatcctagt ggactgggga     2700

gtgctgagca ccctggggca gatagatggc tggagcacca ctcagctccg cattgtggtc     2760

tccagtttcc tacggcagag tggtcggcat gtgagccacc tggacttcgt tcatctgaca     2820

gcgctgggtt atactctctg tggactgcgg ccagaggagc tccagcacat cagcagttgg     2880

gagttcagcc aagcagctct cttcctcggc accctgcatc tccagtgctc tgaggaacaa     2940

ctggaggttc tggcccacct acttgtactg cctggtgggt ttggcccaat cagtaactgg     3000

gggcctgaga tcttcactga aattggcacc atagcagctg ggatcccaga cctggctctt     3060

tcagcactgc tgcggggaca gatccagggc gttactcctc ttgccatttc tgtcatccct     3120

cctcctaaat ttgctgtggt gtttagtccc atccaactat ctagtctcac cagtgctcag     3180

gctgtggctg tcactcctga gcaaatggcc tttctgagtc ctgagcagcg acgagcagtt     3240

gcatgggccc aacatgaggg aaaggagagc ccagaacagc aaggtcgaag tacagcctgg     3300

ggcctccagg actggtcacg accttcctgg tccctggtat tgactatcag cttccttggc     3360

cacctgctaa cgcgtacgcg gccgctcgag cagaaactca tctcagaaga ggatctgtaa     3420

tag                                                                   3423


<210> 18
<211> 1139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys 
            20                  25                  30          


Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu 
        35                  40                  45              


Lys Asn Gly Phe Ile Ala Ser Asn Cys Phe Ser Pro Val Leu Trp Asp 
    50                  55                  60                  


Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln 
65                  70                  75                  80  


Ala Tyr Leu His Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser 
                85                  90                  95      


Ala Glu Arg Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly 
            100                 105                 110         


Lys Leu Gln Gly Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu 
        115                 120                 125             


Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 
    130                 135                 140                 


Gln Leu Phe Ile Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser 
145                 150                 155                 160 


Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 
                165                 170                 175     


Ala Ala Ile Arg Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu 
            180                 185                 190         


Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 
        195                 200                 205             


Ala Trp Pro Gln Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His 
    210                 215                 220                 


Leu Pro Leu Glu Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 
225                 230                 235                 240 


Leu Glu Asp Ser Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg 
                245                 250                 255     


His Val Leu Arg Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu 
            260                 265                 270         


Gln Val Arg Arg Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu 
        275                 280                 285             


Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg 
    290                 295                 300                 


Gly Leu Leu Glu Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg 
305                 310                 315                 320 


Val Ala Tyr Glu Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val 
                325                 330                 335     


Leu Ser Pro Arg Glu Leu Arg Val Trp Ala Pro Leu Phe Ser Gln Leu 
            340                 345                 350         


Gly Leu Arg Phe Leu Gln Glu Leu Ser Glu Pro Gln Leu Arg Ala Met 
        355                 360                 365             


Leu Pro Val Leu Gln Gly Thr Ser Val Thr Pro Ala Gln Ala Val Leu 
    370                 375                 380                 


Leu Leu Gly Arg Leu Leu Pro Arg His Asp Leu Ser Leu Glu Glu Leu 
385                 390                 395                 400 


Cys Ser Leu His Leu Leu Leu Pro Gly Leu Ser Pro Gln Thr Leu Gln 
                405                 410                 415     


Ala Ile Pro Arg Arg Val Leu Val Gly Ala Cys Ser Cys Leu Ala Pro 
            420                 425                 430         


Glu Leu Ser Arg Leu Ser Ala Cys Gln Thr Ala Ala Leu Leu Gln Thr 
        435                 440                 445             


Phe Arg Val Lys Asp Gly Val Lys Asn Met Gly Thr Thr Gly Ala Gly 
    450                 455                 460                 


Pro Ala Val Cys Ile Pro Gly Gln Pro Ile Pro Thr Thr Trp Pro Asp 
465                 470                 475                 480 


Cys Leu Leu Pro Leu Leu Pro Leu Lys Leu Leu Gln Leu Asp Ser Leu 
                485                 490                 495     


Ala Leu Leu Ala Asn Arg Arg Arg Tyr Trp Glu Leu Pro Trp Ser Glu 
            500                 505                 510         


Gln Gln Ala Gln Phe Leu Trp Lys Lys Met Gln Val Pro Thr Asn Leu 
        515                 520                 525             


Thr Leu Arg Asn Leu Gln Ala Leu Gly Thr Leu Ala Gly Gly Met Ser 
    530                 535                 540                 


Cys Glu Phe Leu Gln Gln Ile Asn Ser Met Val Asp Phe Leu Glu Val 
545                 550                 555                 560 


Val His Met Ile Tyr Gln Leu Pro Thr Arg Val Arg Gly Ser Leu Arg 
                565                 570                 575     


Ala Cys Ile Trp Ala Glu Leu Gln Arg Arg Met Ala Met Pro Glu Pro 
            580                 585                 590         


Glu Trp Thr Thr Val Gly Pro Glu Leu Asn Gly Leu Asp Ser Lys Leu 
        595                 600                 605             


Leu Leu Asp Leu Pro Ile Gln Leu Met Asp Arg Leu Ser Asn Glu Ser 
    610                 615                 620                 


Ile Met Leu Val Val Glu Leu Val Gln Arg Ala Pro Glu Gln Leu Leu 
625                 630                 635                 640 


Ala Leu Thr Pro Leu His Gln Ala Ala Leu Ala Glu Arg Ala Leu Gln 
                645                 650                 655     


Asn Leu Ala Pro Lys Glu Thr Pro Val Ser Gly Glu Val Leu Glu Thr 
            660                 665                 670         


Leu Gly Pro Leu Val Gly Phe Leu Gly Thr Glu Ser Thr Arg Gln Ile 
        675                 680                 685             


Pro Leu Gln Ile Leu Leu Ser His Leu Ser Gln Leu Gln Gly Phe Cys 
    690                 695                 700                 


Leu Gly Glu Thr Phe Ala Thr Glu Leu Gly Trp Leu Leu Leu Gln Glu 
705                 710                 715                 720 


Ser Val Leu Gly Lys Pro Glu Leu Trp Ser Gln Asp Glu Val Glu Gln 
                725                 730                 735     


Ala Gly Arg Leu Val Phe Thr Leu Ser Thr Glu Ala Ile Ser Leu Ile 
            740                 745                 750         


Pro Arg Glu Ala Leu Gly Pro Glu Thr Leu Glu Arg Leu Leu Glu Lys 
        755                 760                 765             


Gln Gln Ser Trp Glu Gln Ser Arg Val Gly Gln Leu Cys Arg Glu Pro 
    770                 775                 780                 


Gln Leu Ala Ala Lys Lys Ala Ala Leu Val Ala Gly Val Val Arg Pro 
785                 790                 795                 800 


Ala Ala Glu Asp Leu Pro Glu Pro Val Pro Asn Cys Ala Asp Val Arg 
                805                 810                 815     


Gly Thr Phe Pro Ala Ala Trp Ser Ala Thr Gln Ile Ala Glu Met Glu 
            820                 825                 830         


Leu Ser Asp Phe Glu Asp Cys Leu Thr Leu Phe Ala Gly Asp Pro Gly 
        835                 840                 845             


Leu Gly Pro Glu Glu Leu Arg Ala Ala Met Gly Lys Ala Lys Gln Leu 
    850                 855                 860                 


Trp Gly Pro Pro Arg Gly Phe Arg Pro Glu Gln Ile Leu Gln Leu Gly 
865                 870                 875                 880 


Arg Leu Leu Ile Gly Leu Gly Asp Arg Glu Leu Gln Glu Leu Ile Leu 
                885                 890                 895     


Val Asp Trp Gly Val Leu Ser Thr Leu Gly Gln Ile Asp Gly Trp Ser 
            900                 905                 910         


Thr Thr Gln Leu Arg Ile Val Val Ser Ser Phe Leu Arg Gln Ser Gly 
        915                 920                 925             


Arg His Val Ser His Leu Asp Phe Val His Leu Thr Ala Leu Gly Tyr 
    930                 935                 940                 


Thr Leu Cys Gly Leu Arg Pro Glu Glu Leu Gln His Ile Ser Ser Trp 
945                 950                 955                 960 


Glu Phe Ser Gln Ala Ala Leu Phe Leu Gly Thr Leu His Leu Gln Cys 
                965                 970                 975     


Ser Glu Glu Gln Leu Glu Val Leu Ala His Leu Leu Val Leu Pro Gly 
            980                 985                 990         


Gly Phe Gly Pro Ile Ser Asn Trp  Gly Pro Glu Ile Phe  Thr Glu Ile 
        995                 1000                 1005             


Gly Thr  Ile Ala Ala Gly Ile  Pro Asp Leu Ala Leu  Ser Ala Leu 
    1010                 1015                 1020             


Leu Arg  Gly Gln Ile Gln Gly  Val Thr Pro Leu Ala  Ile Ser Val 
    1025                 1030                 1035             


Ile Pro  Pro Pro Lys Phe Ala  Val Val Phe Ser Pro  Ile Gln Leu 
    1040                 1045                 1050             


Ser Ser  Leu Thr Ser Ala Gln  Ala Val Ala Val Thr  Pro Glu Gln 
    1055                 1060                 1065             


Met Ala  Phe Leu Ser Pro Glu  Gln Arg Arg Ala Val  Ala Trp Ala 
    1070                 1075                 1080             


Gln His  Glu Gly Lys Glu Ser  Pro Glu Gln Gln Gly  Arg Ser Thr 
    1085                 1090                 1095             


Ala Trp  Gly Leu Gln Asp Trp  Ser Arg Pro Ser Trp  Ser Leu Val 
    1100                 1105                 1110             


Leu Thr  Ile Ser Phe Leu Gly  His Leu Leu Thr Arg  Thr Arg Pro 
    1115                 1120                 1125             


Leu Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu 
    1130                 1135                 


<210> 19
<211> 3414
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcaatca agatagctac aaggaagtat cttggcaaac aaaacgttta tgatattgga      120

gtcgaaagag atcacaactt tgctctgaag aacggattca tagcttctaa ttgcttcagt      180

cctgtactgt gggatctact ccagagagag aagagcgttt gggccctgag gaccctggtg      240

aaggcctacc tgcgcatgcc tccagaagac cttcagcagc ttgtgctttc agcagagatg      300

gaggctgcac agggcttcct gacgctcatg cttcgttcct gggctaagct gaaggttcaa      360

ccatccgagg agcaggccat gggccgcctg acagccttgc tgctccagcg gtacccacgc      420

ctcacctccc aactctttat cgacatgtca ccgctcatcc ccttcctggc tgtccctgac      480

ctcatgcgct tcccaccgtc ccttttggcc aacgacagtg tcctggctgc catcagggat      540

cacagctcag gaatgaagcc tgaacagaag gaggccctgg caaaacgact gctggcccct      600

gagctgtttg gagaagtgcc tgattggccc caggagctgc tgtgggcagc cctgcctctg      660

cttccccatc tgcctctgga gagctttctc cagctcagcc ctcaccagat ccaggccctg      720

gaggatagct ggccagtagc agatcttggg ccgggacacg cccgacatgt gcttcgtagc      780

ctagtaaacc agagcatgga ggatggggag gagcaggtgc tcaggcttgg gtccctcgcc      840

tgtttcctga gtcctgagga gctacagagt ctggtgccct tgagtgatcc aatggggcct      900

gtagaacagg gtctgctgga atgtgcggcc aatgggaccc tcagcccaga aggacgggtg      960

gcatatgaac ttctgggagt gttgcgttca tctggaggaa ctgtcttaag cccccgagag     1020

ctgagggtct gggcacctct ctttccccag ctgggcctcc gcttcctgca ggagctctca     1080

gagacccagc ttagagccat gcttcctgcc ctacagggag ccagtgtcac acctgcccag     1140

gctgttctgt tgtttggaag gctccttcct aagcatgatc tgtccctgga ggaactctgc     1200

tccctgcacc ctctcctgcc aggtctcagc ccccagacac tccaggccat ccctaagaga     1260

gttctggttg gtgcttgttc ctgcctgggc cctgaactgt caaggctttc agcttgccag     1320

attgcagctc tgctgcagac ctttcgggta aaagatggtg ttaaaaatat gggtgcagca     1380

ggtgccggct cagccgtgtg cattcctggg cagcccacca cttggccaga ctgcctgctt     1440

cccctgctcc cattaaagct gctacagctg gacgctgcag ctcttctggc aaaccgaaga     1500

ctctatcggc agctgccttg gtctgagcaa caggcacagt ttctctggaa gaaaatgcaa     1560

gtgcctacca acctgagcct gaggaatctg caggctctgg gcaacttggc aggaggcatg     1620

acctgcgagt ttctgcagca gatcagctca atggttgact ttcttgatgt ggtacacatg     1680

ctctaccagc tgcccactgg tgttcgagag agcctgcggg cctgtatctg gacagagcta     1740

cagcggagga tgacaatgcc agagccagag ctgaccaccc tagggccaga actgagtgaa     1800

cttgacacaa agctactcct ggacttgccg atccagctga tggacagatt gtccaatgat     1860

tccattatgt tggtggtgga gatggtccaa ggcgctccag agcagctgct ggcactgacc     1920

ccactccacc agacagcctt ggcagagcga gcacttaaaa acctggctcc aaaggagacc     1980

ccaatctcca aagaagtgct ggagacactg ggccccttgg ttggattcct gggaatagag     2040

agcacgcgac ggatcccttt acccattcta ctgtctcatc tcagtcagct gcagggcttc     2100

tgcctaggag agacatttgc cacagagctg ggatggctgc tgttgcagga gcctgttctt     2160

ggaaaaccag aattgtggag ccaggatgaa atagagcaag ctggacgcct agtattcact     2220

ctgtctgctg aggctatttc ctcgatcccc agggaggctt tgggcccaga gacactggag     2280

aggcttctgg gaaagcatca aagctgggag cagagcagag tgggccatct gtgtggggag     2340

tcacagcttg cccacaagaa agcagctctg gtagctggga ttgtgcatcc agctgctgag     2400

ggtctccaag agcctgtacc aaactgtgca gacatacggg gaaccttccc agcggcctgg     2460

tctgcgacac aaatctcaga gatggaactc tcagactttg aagactgcct gtcactattt     2520

gctggagatc caggacttgg tcctgaggaa ctacgggcag ccatgggcaa ggccaagcag     2580

ttgtggggtc cccctcgagg attccgtcct gagcagatct tgcagctggg ccgtctcctg     2640

ataggtctag gagaacggga actgcaggag cttaccttgg tggactgggg tgtgctgagc     2700

agcctggggc aaatagatgg ctggagttcc atgcagctcc gagccgtggt ctccagtttc     2760

ctaaggcaga gtggtcggca tgtgagccac ctggacttca tttatctgac agcactgggt     2820

tacacagtct gtggattgcg accagaggag ttacagcaca tcagcagttg ggagtttagc     2880

caagcagctc tcttcctggg tagcttgcat ctcccgtgct ctgaggaaca gctggaagtt     2940

ctggcctatc tccttgtgtt gcctggtggc tttggcccag tcagtaactg ggggcctgag     3000

atcttcactg aaattggcac aatagcagct ggcatcccag acctggctct ttcagcatta     3060

ctgcggggac agatccaagg cctgactcct cttgccattt ctgtcattcc tgctcccaag     3120

tttgcagtgg tcttcaaccc catccagtta tctagtctca ccaggggtca ggccgtagct     3180

gttactcctg aacagctggc ctatctgagt cctgagcagc ggcgagcagt tgcatgggcc     3240

caacacgaag ggaaggagat cccagagcag ctgggtcgaa actcagcctg gggtctctac     3300

gactggttcc aagcctcctg ggccctggca ttgcccgtca gcatttttgg ccacctatta     3360

acgcgtacgc ggccgctcga gcagaaactc atctcagaag aggatctgta atag           3414


<210> 20
<211> 1136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly 
            20                  25                  30          


Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala 
        35                  40                  45              


Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Phe Ser Pro Val Leu Trp 
    50                  55                  60                  


Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu Val 
65                  70                  75                  80  


Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val Leu 
                85                  90                  95      


Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Arg 
            100                 105                 110         


Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met Gly 
        115                 120                 125             


Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln 
    130                 135                 140                 


Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro Asp 
145                 150                 155                 160 


Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala 
                165                 170                 175     


Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu Ala 
            180                 185                 190         


Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Asp 
        195                 200                 205             


Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His Leu 
    210                 215                 220                 


Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu 
225                 230                 235                 240 


Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg His 
                245                 250                 255     


Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu Gln 
            260                 265                 270         


Val Leu Arg Leu Gly Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu 
        275                 280                 285             


Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln Gly 
    290                 295                 300                 


Leu Leu Glu Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val 
305                 310                 315                 320 


Ala Tyr Glu Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Thr Val Leu 
                325                 330                 335     


Ser Pro Arg Glu Leu Arg Val Trp Ala Pro Leu Phe Pro Gln Leu Gly 
            340                 345                 350         


Leu Arg Phe Leu Gln Glu Leu Ser Glu Thr Gln Leu Arg Ala Met Leu 
        355                 360                 365             


Pro Ala Leu Gln Gly Ala Ser Val Thr Pro Ala Gln Ala Val Leu Leu 
    370                 375                 380                 


Phe Gly Arg Leu Leu Pro Lys His Asp Leu Ser Leu Glu Glu Leu Cys 
385                 390                 395                 400 


Ser Leu His Pro Leu Leu Pro Gly Leu Ser Pro Gln Thr Leu Gln Ala 
                405                 410                 415     


Ile Pro Lys Arg Val Leu Val Gly Ala Cys Ser Cys Leu Gly Pro Glu 
            420                 425                 430         


Leu Ser Arg Leu Ser Ala Cys Gln Ile Ala Ala Leu Leu Gln Thr Phe 
        435                 440                 445             


Arg Val Lys Asp Gly Val Lys Asn Met Gly Ala Ala Gly Ala Gly Ser 
    450                 455                 460                 


Ala Val Cys Ile Pro Gly Gln Pro Thr Thr Trp Pro Asp Cys Leu Leu 
465                 470                 475                 480 


Pro Leu Leu Pro Leu Lys Leu Leu Gln Leu Asp Ala Ala Ala Leu Leu 
                485                 490                 495     


Ala Asn Arg Arg Leu Tyr Arg Gln Leu Pro Trp Ser Glu Gln Gln Ala 
            500                 505                 510         


Gln Phe Leu Trp Lys Lys Met Gln Val Pro Thr Asn Leu Ser Leu Arg 
        515                 520                 525             


Asn Leu Gln Ala Leu Gly Asn Leu Ala Gly Gly Met Thr Cys Glu Phe 
    530                 535                 540                 


Leu Gln Gln Ile Ser Ser Met Val Asp Phe Leu Asp Val Val His Met 
545                 550                 555                 560 


Leu Tyr Gln Leu Pro Thr Gly Val Arg Glu Ser Leu Arg Ala Cys Ile 
                565                 570                 575     


Trp Thr Glu Leu Gln Arg Arg Met Thr Met Pro Glu Pro Glu Leu Thr 
            580                 585                 590         


Thr Leu Gly Pro Glu Leu Ser Glu Leu Asp Thr Lys Leu Leu Leu Asp 
        595                 600                 605             


Leu Pro Ile Gln Leu Met Asp Arg Leu Ser Asn Asp Ser Ile Met Leu 
    610                 615                 620                 


Val Val Glu Met Val Gln Gly Ala Pro Glu Gln Leu Leu Ala Leu Thr 
625                 630                 635                 640 


Pro Leu His Gln Thr Ala Leu Ala Glu Arg Ala Leu Lys Asn Leu Ala 
                645                 650                 655     


Pro Lys Glu Thr Pro Ile Ser Lys Glu Val Leu Glu Thr Leu Gly Pro 
            660                 665                 670         


Leu Val Gly Phe Leu Gly Ile Glu Ser Thr Arg Arg Ile Pro Leu Pro 
        675                 680                 685             


Ile Leu Leu Ser His Leu Ser Gln Leu Gln Gly Phe Cys Leu Gly Glu 
    690                 695                 700                 


Thr Phe Ala Thr Glu Leu Gly Trp Leu Leu Leu Gln Glu Pro Val Leu 
705                 710                 715                 720 


Gly Lys Pro Glu Leu Trp Ser Gln Asp Glu Ile Glu Gln Ala Gly Arg 
                725                 730                 735     


Leu Val Phe Thr Leu Ser Ala Glu Ala Ile Ser Ser Ile Pro Arg Glu 
            740                 745                 750         


Ala Leu Gly Pro Glu Thr Leu Glu Arg Leu Leu Gly Lys His Gln Ser 
        755                 760                 765             


Trp Glu Gln Ser Arg Val Gly His Leu Cys Gly Glu Ser Gln Leu Ala 
    770                 775                 780                 


His Lys Lys Ala Ala Leu Val Ala Gly Ile Val His Pro Ala Ala Glu 
785                 790                 795                 800 


Gly Leu Gln Glu Pro Val Pro Asn Cys Ala Asp Ile Arg Gly Thr Phe 
                805                 810                 815     


Pro Ala Ala Trp Ser Ala Thr Gln Ile Ser Glu Met Glu Leu Ser Asp 
            820                 825                 830         


Phe Glu Asp Cys Leu Ser Leu Phe Ala Gly Asp Pro Gly Leu Gly Pro 
        835                 840                 845             


Glu Glu Leu Arg Ala Ala Met Gly Lys Ala Lys Gln Leu Trp Gly Pro 
    850                 855                 860                 


Pro Arg Gly Phe Arg Pro Glu Gln Ile Leu Gln Leu Gly Arg Leu Leu 
865                 870                 875                 880 


Ile Gly Leu Gly Glu Arg Glu Leu Gln Glu Leu Thr Leu Val Asp Trp 
                885                 890                 895     


Gly Val Leu Ser Ser Leu Gly Gln Ile Asp Gly Trp Ser Ser Met Gln 
            900                 905                 910         


Leu Arg Ala Val Val Ser Ser Phe Leu Arg Gln Ser Gly Arg His Val 
        915                 920                 925             


Ser His Leu Asp Phe Ile Tyr Leu Thr Ala Leu Gly Tyr Thr Val Cys 
    930                 935                 940                 


Gly Leu Arg Pro Glu Glu Leu Gln His Ile Ser Ser Trp Glu Phe Ser 
945                 950                 955                 960 


Gln Ala Ala Leu Phe Leu Gly Ser Leu His Leu Pro Cys Ser Glu Glu 
                965                 970                 975     


Gln Leu Glu Val Leu Ala Tyr Leu Leu Val Leu Pro Gly Gly Phe Gly 
            980                 985                 990         


Pro Val Ser Asn Trp Gly Pro Glu  Ile Phe Thr Glu Ile  Gly Thr Ile 
        995                 1000                 1005             


Ala Ala  Gly Ile Pro Asp Leu  Ala Leu Ser Ala Leu  Leu Arg Gly 
    1010                 1015                 1020             


Gln Ile  Gln Gly Leu Thr Pro  Leu Ala Ile Ser Val  Ile Pro Ala 
    1025                 1030                 1035             


Pro Lys  Phe Ala Val Val Phe  Asn Pro Ile Gln Leu  Ser Ser Leu 
    1040                 1045                 1050             


Thr Arg  Gly Gln Ala Val Ala  Val Thr Pro Glu Gln  Leu Ala Tyr 
    1055                 1060                 1065             


Leu Ser  Pro Glu Gln Arg Arg  Ala Val Ala Trp Ala  Gln His Glu 
    1070                 1075                 1080             


Gly Lys  Glu Ile Pro Glu Gln  Leu Gly Arg Asn Ser  Ala Trp Gly 
    1085                 1090                 1095             


Leu Tyr  Asp Trp Phe Gln Ala  Ser Trp Ala Leu Ala  Leu Pro Val 
    1100                 1105                 1110             


Ser Ile  Phe Gly His Leu Leu  Thr Arg Thr Arg Pro  Leu Glu Gln 
    1115                 1120                 1125             


Lys Leu  Ile Ser Glu Glu Asp  Leu 
    1130                 1135     


<210> 21
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atcaagatag ctacaaggaa gtatcttggc aaacaaaacg tttatgatat tggagtcgaa       60

agagatcaca actttgctct gaagaacgga ttcatagctt ctaat                      105


<210> 22
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 
            20                  25                  30          


Ala Ser Asn 
        35  


<210> 23
<211> 1067
<212> PRT
<213> Homo sapiens

<400> 23
Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg Glu Lys Ser Val 
1               5                   10                  15      


Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His Met Pro Pro Glu 
            20                  25                  30          


Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu Ala Ala Gln Gly 
        35                  40                  45              


Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly Lys Leu Gln Val 
    50                  55                  60                  


Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr Ala Leu Leu Leu 
65                  70                  75                  80  


Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile Asp Leu Ser Pro 
                85                  90                  95      


Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg Phe Pro Pro Ser 
            100                 105                 110         


Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg Asp Tyr Ser Pro 
        115                 120                 125             


Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys Arg Leu Leu Ala 
    130                 135                 140                 


Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln Glu Leu Leu Trp 
145                 150                 155                 160 


Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu Asn Phe Leu Gln 
                165                 170                 175     


Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser Trp Pro Ala Ala 
            180                 185                 190         


Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg Ser Leu Val Asn 
        195                 200                 205             


Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg Leu Gly Pro Leu 
    210                 215                 220                 


Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu Val Pro Leu Ser 
225                 230                 235                 240 


Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu Cys Ala Ala Asn 
                245                 250                 255     


Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu Leu Leu Gly Val 
            260                 265                 270         


Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg Glu Leu Arg Val 
        275                 280                 285             


Trp Ala Pro Leu Phe Ser Gln Leu Gly Leu Arg Phe Leu Gln Glu Leu 
    290                 295                 300                 


Ser Glu Pro Gln Leu Arg Ala Met Leu Pro Val Leu Gln Gly Thr Ser 
305                 310                 315                 320 


Val Thr Pro Ala Gln Ala Val Leu Leu Leu Gly Arg Leu Leu Pro Arg 
                325                 330                 335     


His Asp Leu Ser Leu Glu Glu Leu Cys Ser Leu His Leu Leu Leu Pro 
            340                 345                 350         


Gly Leu Ser Pro Gln Thr Leu Gln Ala Ile Pro Arg Arg Val Leu Val 
        355                 360                 365             


Gly Ala Cys Ser Cys Leu Ala Pro Glu Leu Ser Arg Leu Ser Ala Cys 
    370                 375                 380                 


Gln Thr Ala Ala Leu Leu Gln Thr Phe Arg Val Lys Asp Gly Val Lys 
385                 390                 395                 400 


Asn Met Gly Thr Thr Gly Ala Gly Pro Ala Val Cys Ile Pro Gly Gln 
                405                 410                 415     


Pro Ile Pro Thr Thr Trp Pro Asp Cys Leu Leu Pro Leu Leu Pro Leu 
            420                 425                 430         


Lys Leu Leu Gln Leu Asp Ser Leu Ala Leu Leu Ala Asn Arg Arg Arg 
        435                 440                 445             


Tyr Trp Glu Leu Pro Trp Ser Glu Gln Gln Ala Gln Phe Leu Trp Lys 
    450                 455                 460                 


Lys Met Gln Val Pro Thr Asn Leu Thr Leu Arg Asn Leu Gln Ala Leu 
465                 470                 475                 480 


Gly Thr Leu Ala Gly Gly Met Ser Cys Glu Phe Leu Gln Gln Ile Asn 
                485                 490                 495     


Ser Met Val Asp Phe Leu Glu Val Val His Met Ile Tyr Gln Leu Pro 
            500                 505                 510         


Thr Arg Val Arg Gly Ser Leu Arg Ala Cys Ile Trp Ala Glu Leu Gln 
        515                 520                 525             


Arg Arg Met Ala Met Pro Glu Pro Glu Trp Thr Thr Val Gly Pro Glu 
    530                 535                 540                 


Leu Asn Gly Leu Asp Ser Lys Leu Leu Leu Asp Leu Pro Ile Gln Leu 
545                 550                 555                 560 


Met Asp Arg Leu Ser Asn Glu Ser Ile Met Leu Val Val Glu Leu Val 
                565                 570                 575     


Gln Arg Ala Pro Glu Gln Leu Leu Ala Leu Thr Pro Leu His Gln Ala 
            580                 585                 590         


Ala Leu Ala Glu Arg Ala Leu Gln Asn Leu Ala Pro Lys Glu Thr Pro 
        595                 600                 605             


Val Ser Gly Glu Val Leu Glu Thr Leu Gly Pro Leu Val Gly Phe Leu 
    610                 615                 620                 


Gly Thr Glu Ser Thr Arg Gln Ile Pro Leu Gln Ile Leu Leu Ser His 
625                 630                 635                 640 


Leu Ser Gln Leu Gln Gly Phe Cys Leu Gly Glu Thr Phe Ala Thr Glu 
                645                 650                 655     


Leu Gly Trp Leu Leu Leu Gln Glu Ser Val Leu Gly Lys Pro Glu Leu 
            660                 665                 670         


Trp Ser Gln Asp Glu Val Glu Gln Ala Gly Arg Leu Val Phe Thr Leu 
        675                 680                 685             


Ser Thr Glu Ala Ile Ser Leu Ile Pro Arg Glu Ala Leu Gly Pro Glu 
    690                 695                 700                 


Thr Leu Glu Arg Leu Leu Glu Lys Gln Gln Ser Trp Glu Gln Ser Arg 
705                 710                 715                 720 


Val Gly Gln Leu Cys Arg Glu Pro Gln Leu Ala Ala Lys Lys Ala Ala 
                725                 730                 735     


Leu Val Ala Gly Val Val Arg Pro Ala Ala Glu Asp Leu Pro Glu Pro 
            740                 745                 750         


Val Pro Asn Cys Ala Asp Val Arg Gly Thr Phe Pro Ala Ala Trp Ser 
        755                 760                 765             


Ala Thr Gln Ile Ala Glu Met Glu Leu Ser Asp Phe Glu Asp Cys Leu 
    770                 775                 780                 


Thr Leu Phe Ala Gly Asp Pro Gly Leu Gly Pro Glu Glu Leu Arg Ala 
785                 790                 795                 800 


Ala Met Gly Lys Ala Lys Gln Leu Trp Gly Pro Pro Arg Gly Phe Arg 
                805                 810                 815     


Pro Glu Gln Ile Leu Gln Leu Gly Arg Leu Leu Ile Gly Leu Gly Asp 
            820                 825                 830         


Arg Glu Leu Gln Glu Leu Ile Leu Val Asp Trp Gly Val Leu Ser Thr 
        835                 840                 845             


Leu Gly Gln Ile Asp Gly Trp Ser Thr Thr Gln Leu Arg Ile Val Val 
    850                 855                 860                 


Ser Ser Phe Leu Arg Gln Ser Gly Arg His Val Ser His Leu Asp Phe 
865                 870                 875                 880 


Val His Leu Thr Ala Leu Gly Tyr Thr Leu Cys Gly Leu Arg Pro Glu 
                885                 890                 895     


Glu Leu Gln His Ile Ser Ser Trp Glu Phe Ser Gln Ala Ala Leu Phe 
            900                 905                 910         


Leu Gly Thr Leu His Leu Gln Cys Ser Glu Glu Gln Leu Glu Val Leu 
        915                 920                 925             


Ala His Leu Leu Val Leu Pro Gly Gly Phe Gly Pro Ile Ser Asn Trp 
    930                 935                 940                 


Gly Pro Glu Ile Phe Thr Glu Ile Gly Thr Ile Ala Ala Gly Ile Pro 
945                 950                 955                 960 


Asp Leu Ala Leu Ser Ala Leu Leu Arg Gly Gln Ile Gln Gly Val Thr 
                965                 970                 975     


Pro Leu Ala Ile Ser Val Ile Pro Pro Pro Lys Phe Ala Val Val Phe 
            980                 985                 990         


Ser Pro Ile Gln Leu Ser Ser Leu  Thr Ser Ala Gln Ala  Val Ala Val 
        995                 1000                 1005             


Thr Pro  Glu Gln Met Ala Phe  Leu Ser Pro Glu Gln  Arg Arg Ala 
    1010                 1015                 1020             


Val Ala  Trp Ala Gln His Glu  Gly Lys Glu Ser Pro  Glu Gln Gln 
    1025                 1030                 1035             


Gly Arg  Ser Thr Ala Trp Gly  Leu Gln Asp Trp Ser  Arg Pro Ser 
    1040                 1045                 1050             


Trp Ser  Leu Val Leu Thr Ile  Ser Phe Leu Gly His  Leu Leu 
    1055                 1060                 1065         


<210> 24
<211> 1063
<212> PRT
<213> Mus musculus

<400> 24
Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg Glu Lys Ser Val 
1               5                   10                  15      


Trp Ala Leu Arg Thr Leu Val Lys Ala Tyr Leu Arg Met Pro Pro Glu 
            20                  25                  30          


Asp Leu Gln Gln Leu Val Leu Ser Ala Glu Met Glu Ala Ala Gln Gly 
        35                  40                  45              


Phe Leu Thr Leu Met Leu Arg Ser Trp Ala Lys Leu Lys Val Gln Pro 
    50                  55                  60                  


Ser Glu Glu Gln Ala Met Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg 
65                  70                  75                  80  


Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile Asp Met Ser Pro Leu Ile 
                85                  90                  95      


Pro Phe Leu Ala Val Pro Asp Leu Met Arg Phe Pro Pro Ser Leu Leu 
            100                 105                 110         


Ala Asn Asp Ser Val Leu Ala Ala Ile Arg Asp His Ser Ser Gly Met 
        115                 120                 125             


Lys Pro Glu Gln Lys Glu Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu 
    130                 135                 140                 


Leu Phe Gly Glu Val Pro Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala 
145                 150                 155                 160 


Leu Pro Leu Leu Pro His Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser 
                165                 170                 175     


Pro His Gln Ile Gln Ala Leu Glu Asp Ser Trp Pro Val Ala Asp Leu 
            180                 185                 190         


Gly Pro Gly His Ala Arg His Val Leu Arg Ser Leu Val Asn Gln Ser 
        195                 200                 205             


Met Glu Asp Gly Glu Glu Gln Val Leu Arg Leu Gly Ser Leu Ala Cys 
    210                 215                 220                 


Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu Val Pro Leu Ser Asp Pro 
225                 230                 235                 240 


Met Gly Pro Val Glu Gln Gly Leu Leu Glu Cys Ala Ala Asn Gly Thr 
                245                 250                 255     


Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu Leu Leu Gly Val Leu Arg 
            260                 265                 270         


Ser Ser Gly Gly Thr Val Leu Ser Pro Arg Glu Leu Arg Val Trp Ala 
        275                 280                 285             


Pro Leu Phe Pro Gln Leu Gly Leu Arg Phe Leu Gln Glu Leu Ser Glu 
    290                 295                 300                 


Thr Gln Leu Arg Ala Met Leu Pro Ala Leu Gln Gly Ala Ser Val Thr 
305                 310                 315                 320 


Pro Ala Gln Ala Val Leu Leu Phe Gly Arg Leu Leu Pro Lys His Asp 
                325                 330                 335     


Leu Ser Leu Glu Glu Leu Cys Ser Leu His Pro Leu Leu Pro Gly Leu 
            340                 345                 350         


Ser Pro Gln Thr Leu Gln Ala Ile Pro Lys Arg Val Leu Val Gly Ala 
        355                 360                 365             


Cys Ser Cys Leu Gly Pro Glu Leu Ser Arg Leu Ser Ala Cys Gln Ile 
    370                 375                 380                 


Ala Ala Leu Leu Gln Thr Phe Arg Val Lys Asp Gly Val Lys Asn Met 
385                 390                 395                 400 


Gly Ala Ala Gly Ala Gly Ser Ala Val Cys Ile Pro Gly Gln Pro Thr 
                405                 410                 415     


Thr Trp Pro Asp Cys Leu Leu Pro Leu Leu Pro Leu Lys Leu Leu Gln 
            420                 425                 430         


Leu Asp Ala Ala Ala Leu Leu Ala Asn Arg Arg Leu Tyr Arg Gln Leu 
        435                 440                 445             


Pro Trp Ser Glu Gln Gln Ala Gln Phe Leu Trp Lys Lys Met Gln Val 
    450                 455                 460                 


Pro Thr Asn Leu Ser Leu Arg Asn Leu Gln Ala Leu Gly Asn Leu Ala 
465                 470                 475                 480 


Gly Gly Met Thr Cys Glu Phe Leu Gln Gln Ile Ser Ser Met Val Asp 
                485                 490                 495     


Phe Leu Asp Val Val His Met Leu Tyr Gln Leu Pro Thr Gly Val Arg 
            500                 505                 510         


Glu Ser Leu Arg Ala Cys Ile Trp Thr Glu Leu Gln Arg Arg Met Thr 
        515                 520                 525             


Met Pro Glu Pro Glu Leu Thr Thr Leu Gly Pro Glu Leu Ser Glu Leu 
    530                 535                 540                 


Asp Thr Lys Leu Leu Leu Asp Leu Pro Ile Gln Leu Met Asp Arg Leu 
545                 550                 555                 560 


Ser Asn Asp Ser Ile Met Leu Val Val Glu Met Val Gln Gly Ala Pro 
                565                 570                 575     


Glu Gln Leu Leu Ala Leu Thr Pro Leu His Gln Thr Ala Leu Ala Glu 
            580                 585                 590         


Arg Ala Leu Lys Asn Leu Ala Pro Lys Glu Thr Pro Ile Ser Lys Glu 
        595                 600                 605             


Val Leu Glu Thr Leu Gly Pro Leu Val Gly Phe Leu Gly Ile Glu Ser 
    610                 615                 620                 


Thr Arg Arg Ile Pro Leu Pro Ile Leu Leu Ser His Leu Ser Gln Leu 
625                 630                 635                 640 


Gln Gly Phe Cys Leu Gly Glu Thr Phe Ala Thr Glu Leu Gly Trp Leu 
                645                 650                 655     


Leu Leu Gln Glu Pro Val Leu Gly Lys Pro Glu Leu Trp Ser Gln Asp 
            660                 665                 670         


Glu Ile Glu Gln Ala Gly Arg Leu Val Phe Thr Leu Ser Ala Glu Ala 
        675                 680                 685             


Ile Ser Ser Ile Pro Arg Glu Ala Leu Gly Pro Glu Thr Leu Glu Arg 
    690                 695                 700                 


Leu Leu Gly Lys His Gln Ser Trp Glu Gln Ser Arg Val Gly His Leu 
705                 710                 715                 720 


Cys Gly Glu Ser Gln Leu Ala His Lys Lys Ala Ala Leu Val Ala Gly 
                725                 730                 735     


Ile Val His Pro Ala Ala Glu Gly Leu Gln Glu Pro Val Pro Asn Cys 
            740                 745                 750         


Ala Asp Ile Arg Gly Thr Phe Pro Ala Ala Trp Ser Ala Thr Gln Ile 
        755                 760                 765             


Ser Glu Met Glu Leu Ser Asp Phe Glu Asp Cys Leu Ser Leu Phe Ala 
    770                 775                 780                 


Gly Asp Pro Gly Leu Gly Pro Glu Glu Leu Arg Ala Ala Met Gly Lys 
785                 790                 795                 800 


Ala Lys Gln Leu Trp Gly Pro Pro Arg Gly Phe Arg Pro Glu Gln Ile 
                805                 810                 815     


Leu Gln Leu Gly Arg Leu Leu Ile Gly Leu Gly Glu Arg Glu Leu Gln 
            820                 825                 830         


Glu Leu Thr Leu Val Asp Trp Gly Val Leu Ser Ser Leu Gly Gln Ile 
        835                 840                 845             


Asp Gly Trp Ser Ser Met Gln Leu Arg Ala Val Val Ser Ser Phe Leu 
    850                 855                 860                 


Arg Gln Ser Gly Arg His Val Ser His Leu Asp Phe Ile Tyr Leu Thr 
865                 870                 875                 880 


Ala Leu Gly Tyr Thr Val Cys Gly Leu Arg Pro Glu Glu Leu Gln His 
                885                 890                 895     


Ile Ser Ser Trp Glu Phe Ser Gln Ala Ala Leu Phe Leu Gly Ser Leu 
            900                 905                 910         


His Leu Pro Cys Ser Glu Glu Gln Leu Glu Val Leu Ala Tyr Leu Leu 
        915                 920                 925             


Val Leu Pro Gly Gly Phe Gly Pro Val Ser Asn Trp Gly Pro Glu Ile 
    930                 935                 940                 


Phe Thr Glu Ile Gly Thr Ile Ala Ala Gly Ile Pro Asp Leu Ala Leu 
945                 950                 955                 960 


Ser Ala Leu Leu Arg Gly Gln Ile Gln Gly Leu Thr Pro Leu Ala Ile 
                965                 970                 975     


Ser Val Ile Pro Ala Pro Lys Phe Ala Val Val Phe Asn Pro Ile Gln 
            980                 985                 990         


Leu Ser Ser Leu Thr Arg Gly Gln  Ala Val Ala Val Thr  Pro Glu Gln 
        995                 1000                 1005             


Leu Ala  Tyr Leu Ser Pro Glu  Gln Arg Arg Ala Val  Ala Trp Ala 
    1010                 1015                 1020             


Gln His  Glu Gly Lys Glu Ile  Pro Glu Gln Leu Gly  Arg Asn Ser 
    1025                 1030                 1035             


Ala Trp  Gly Leu Tyr Asp Trp  Phe Gln Ala Ser Trp  Ala Leu Ala 
    1040                 1045                 1050             


Leu Pro  Val Ser Ile Phe Gly  His Leu Leu 
    1055                 1060             


<210> 25
<211> 1775
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 
            20                  25                  30          


Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 
        35                  40                  45              


Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 
    50                  55                  60                  


Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 
65                  70                  75                  80  


Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 
                85                  90                  95      


Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 
            100                 105                 110         


Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 
        115                 120                 125             


Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 
    130                 135                 140                 


Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 
                165                 170                 175     


Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 
            180                 185                 190         


Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 
        195                 200                 205             


Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 
225                 230                 235                 240 


Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 
                245                 250                 255     


Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 
            260                 265                 270         


Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 
        275                 280                 285             


Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 
    290                 295                 300                 


Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 
305                 310                 315                 320 


Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 
                325                 330                 335     


His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 
            340                 345                 350         


Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 
        355                 360                 365             


Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 
    370                 375                 380                 


Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 
385                 390                 395                 400 


Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 
                405                 410                 415     


Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 
            420                 425                 430         


Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 
        435                 440                 445             


Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 
    450                 455                 460                 


Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 
465                 470                 475                 480 


Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 
                485                 490                 495     


Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 
            500                 505                 510         


Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 
        515                 520                 525             


Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 
    530                 535                 540                 


Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 
545                 550                 555                 560 


Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 
                565                 570                 575     


Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 
            580                 585                 590         


Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 
        595                 600                 605             


Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 
    610                 615                 620                 


Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 
625                 630                 635                 640 


Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 
                645                 650                 655     


Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 
            660                 665                 670         


Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 
        675                 680                 685             


Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 
    690                 695                 700                 


Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 
705                 710                 715                 720 


Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His 
                725                 730                 735     


Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu 
            740                 745                 750         


Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly 
        755                 760                 765             


Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr 
    770                 775                 780                 


Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile 
785                 790                 795                 800 


Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg 
                805                 810                 815     


Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg 
            820                 825                 830         


Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys 
        835                 840                 845             


Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln 
    850                 855                 860                 


Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu 
865                 870                 875                 880 


Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser 
                885                 890                 895     


Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg 
            900                 905                 910         


Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg 
        915                 920                 925             


Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu 
    930                 935                 940                 


Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu 
945                 950                 955                 960 


Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu 
                965                 970                 975     


Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg 
            980                 985                 990         


Glu Leu Arg Val Trp Ala Pro Leu  Phe Ser Gln Leu Gly  Leu Arg Phe 
        995                 1000                 1005             


Leu Gln  Glu Leu Ser Glu Pro  Gln Leu Arg Ala Met  Leu Pro Val 
    1010                 1015                 1020             


Leu Gln  Gly Thr Ser Val Thr  Pro Ala Gln Ala Val  Leu Leu Leu 
    1025                 1030                 1035             


Gly Arg  Leu Leu Pro Arg His  Asp Leu Ser Leu Glu  Glu Leu Cys 
    1040                 1045                 1050             


Ser Leu  His Leu Leu Leu Pro  Gly Leu Ser Pro Gln  Thr Leu Gln 
    1055                 1060                 1065             


Ala Ile  Pro Arg Arg Val Leu  Val Gly Ala Cys Ser  Cys Leu Ala 
    1070                 1075                 1080             


Pro Glu  Leu Ser Arg Leu Ser  Ala Cys Gln Thr Ala  Ala Leu Leu 
    1085                 1090                 1095             


Gln Thr  Phe Arg Val Lys Asp  Gly Val Lys Asn Met  Gly Thr Thr 
    1100                 1105                 1110             


Gly Ala  Gly Pro Ala Val Cys  Ile Pro Gly Gln Pro  Ile Pro Thr 
    1115                 1120                 1125             


Thr Trp  Pro Asp Cys Leu Leu  Pro Leu Leu Pro Leu  Lys Leu Leu 
    1130                 1135                 1140             


Gln Leu  Asp Ser Leu Ala Leu  Leu Ala Asn Arg Arg  Arg Tyr Trp 
    1145                 1150                 1155             


Glu Leu  Pro Trp Ser Glu Gln  Gln Ala Gln Phe Leu  Trp Lys Lys 
    1160                 1165                 1170             


Met Gln  Val Pro Thr Asn Leu  Thr Leu Arg Asn Leu  Gln Ala Leu 
    1175                 1180                 1185             


Gly Thr  Leu Ala Gly Gly Met  Ser Cys Glu Phe Leu  Gln Gln Ile 
    1190                 1195                 1200             


Asn Ser  Met Val Asp Phe Leu  Glu Val Val His Met  Ile Tyr Gln 
    1205                 1210                 1215             


Leu Pro  Thr Arg Val Arg Gly  Ser Leu Arg Ala Cys  Ile Trp Ala 
    1220                 1225                 1230             


Glu Leu  Gln Arg Arg Met Ala  Met Pro Glu Pro Glu  Trp Thr Thr 
    1235                 1240                 1245             


Val Gly  Pro Glu Leu Asn Gly  Leu Asp Ser Lys Leu  Leu Leu Asp 
    1250                 1255                 1260             


Leu Pro  Ile Gln Leu Met Asp  Arg Leu Ser Asn Glu  Ser Ile Met 
    1265                 1270                 1275             


Leu Val  Val Glu Leu Val Gln  Arg Ala Pro Glu Gln  Leu Leu Ala 
    1280                 1285                 1290             


Leu Thr  Pro Leu His Gln Ala  Ala Leu Ala Glu Arg  Ala Leu Gln 
    1295                 1300                 1305             


Asn Leu  Ala Pro Lys Glu Thr  Pro Val Ser Gly Glu  Val Leu Glu 
    1310                 1315                 1320             


Thr Leu  Gly Pro Leu Val Gly  Phe Leu Gly Thr Glu  Ser Thr Arg 
    1325                 1330                 1335             


Gln Ile  Pro Leu Gln Ile Leu  Leu Ser His Leu Ser  Gln Leu Gln 
    1340                 1345                 1350             


Gly Phe  Cys Leu Gly Glu Thr  Phe Ala Thr Glu Leu  Gly Trp Leu 
    1355                 1360                 1365             


Leu Leu  Gln Glu Ser Val Leu  Gly Lys Pro Glu Leu  Trp Ser Gln 
    1370                 1375                 1380             


Asp Glu  Val Glu Gln Ala Gly  Arg Leu Val Phe Thr  Leu Ser Thr 
    1385                 1390                 1395             


Glu Ala  Ile Ser Leu Ile Pro  Arg Glu Ala Leu Gly  Pro Glu Thr 
    1400                 1405                 1410             


Leu Glu  Arg Leu Leu Glu Lys  Gln Gln Ser Trp Glu  Gln Ser Arg 
    1415                 1420                 1425             


Val Gly  Gln Leu Cys Arg Glu  Pro Gln Leu Ala Ala  Lys Lys Ala 
    1430                 1435                 1440             


Ala Leu  Val Ala Gly Val Val  Arg Pro Ala Ala Glu  Asp Leu Pro 
    1445                 1450                 1455             


Glu Pro  Val Pro Asn Cys Ala  Asp Val Arg Gly Thr  Phe Pro Ala 
    1460                 1465                 1470             


Ala Trp  Ser Ala Thr Gln Ile  Ala Glu Met Glu Leu  Ser Asp Phe 
    1475                 1480                 1485             


Glu Asp  Cys Leu Thr Leu Phe  Ala Gly Asp Pro Gly  Leu Gly Pro 
    1490                 1495                 1500             


Glu Glu  Leu Arg Ala Ala Met  Gly Lys Ala Lys Gln  Leu Trp Gly 
    1505                 1510                 1515             


Pro Pro  Arg Gly Phe Arg Pro  Glu Gln Ile Leu Gln  Leu Gly Arg 
    1520                 1525                 1530             


Leu Leu  Ile Gly Leu Gly Asp  Arg Glu Leu Gln Glu  Leu Ile Leu 
    1535                 1540                 1545             


Val Asp  Trp Gly Val Leu Ser  Thr Leu Gly Gln Ile  Asp Gly Trp 
    1550                 1555                 1560             


Ser Thr  Thr Gln Leu Arg Ile  Val Val Ser Ser Phe  Leu Arg Gln 
    1565                 1570                 1575             


Ser Gly  Arg His Val Ser His  Leu Asp Phe Val His  Leu Thr Ala 
    1580                 1585                 1590             


Leu Gly  Tyr Thr Leu Cys Gly  Leu Arg Pro Glu Glu  Leu Gln His 
    1595                 1600                 1605             


Ile Ser  Ser Trp Glu Phe Ser  Gln Ala Ala Leu Phe  Leu Gly Thr 
    1610                 1615                 1620             


Leu His  Leu Gln Cys Ser Glu  Glu Gln Leu Glu Val  Leu Ala His 
    1625                 1630                 1635             


Leu Leu  Val Leu Pro Gly Gly  Phe Gly Pro Ile Ser  Asn Trp Gly 
    1640                 1645                 1650             


Pro Glu  Ile Phe Thr Glu Ile  Gly Thr Ile Ala Ala  Gly Ile Pro 
    1655                 1660                 1665             


Asp Leu  Ala Leu Ser Ala Leu  Leu Arg Gly Gln Ile  Gln Gly Val 
    1670                 1675                 1680             


Thr Pro  Leu Ala Ile Ser Val  Ile Pro Pro Pro Lys  Phe Ala Val 
    1685                 1690                 1695             


Val Phe  Ser Pro Ile Gln Leu  Ser Ser Leu Thr Ser  Ala Gln Ala 
    1700                 1705                 1710             


Val Ala  Val Thr Pro Glu Gln  Met Ala Phe Leu Ser  Pro Glu Gln 
    1715                 1720                 1725             


Arg Arg  Ala Val Ala Trp Ala  Gln His Glu Gly Lys  Glu Ser Pro 
    1730                 1735                 1740             


Glu Gln  Gln Gly Arg Ser Thr  Ala Trp Gly Leu Gln  Asp Trp Ser 
    1745                 1750                 1755             


Arg Pro  Ser Trp Ser Leu Val  Leu Thr Ile Ser Phe  Leu Gly His 
    1760                 1765                 1770             


Leu Leu  
    1775 


<210> 26
<211> 1809
<212> PRT
<213> Mus musculus

<400> 26
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 
            20                  25                  30          


Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 
        35                  40                  45              


Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 
    50                  55                  60                  


Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 
65                  70                  75                  80  


Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 
                85                  90                  95      


Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 
            100                 105                 110         


Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 
        115                 120                 125             


Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 
    130                 135                 140                 


Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 
145                 150                 155                 160 


Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 
                165                 170                 175     


Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 
            180                 185                 190         


Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 
        195                 200                 205             


Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 
    210                 215                 220                 


Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 
225                 230                 235                 240 


Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 
                245                 250                 255     


Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 
            260                 265                 270         


Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 
        275                 280                 285             


Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 
    290                 295                 300                 


Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 
305                 310                 315                 320 


Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 
                325                 330                 335     


Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 
            340                 345                 350         


His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 
        355                 360                 365             


Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 
    370                 375                 380                 


Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 
                405                 410                 415     


Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 
            420                 425                 430         


Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 
        435                 440                 445             


Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 
    450                 455                 460                 


Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 
465                 470                 475                 480 


Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 
                485                 490                 495     


Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 
            500                 505                 510         


Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 
        515                 520                 525             


Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 
    530                 535                 540                 


Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 
545                 550                 555                 560 


Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 
                565                 570                 575     


Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 
            580                 585                 590         


Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 
        595                 600                 605             


Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 
    610                 615                 620                 


Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 
625                 630                 635                 640 


Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 
                645                 650                 655     


Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 
            660                 665                 670         


Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 
        675                 680                 685             


Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 
    690                 695                 700                 


Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 
705                 710                 715                 720 


Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 
                725                 730                 735     


Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Phe Ser Pro Val Leu 
            740                 745                 750         


Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu 
        755                 760                 765             


Val Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val 
    770                 775                 780                 


Leu Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu 
785                 790                 795                 800 


Arg Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met 
                805                 810                 815     


Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 
            820                 825                 830         


Gln Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro 
        835                 840                 845             


Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 
    850                 855                 860                 


Ala Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu 
865                 870                 875                 880 


Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 
                885                 890                 895     


Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His 
            900                 905                 910         


Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 
        915                 920                 925             


Leu Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg 
    930                 935                 940                 


His Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu 
945                 950                 955                 960 


Gln Val Leu Arg Leu Gly Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu 
                965                 970                 975     


Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln 
            980                 985                 990         


Gly Leu Leu Glu Cys Ala Ala Asn  Gly Thr Leu Ser Pro  Glu Gly Arg 
        995                 1000                 1005             


Val Ala  Tyr Glu Leu Leu Gly  Val Leu Arg Ser Ser  Gly Gly Thr 
    1010                 1015                 1020             


Val Leu  Ser Pro Arg Glu Leu  Arg Val Trp Ala Pro  Leu Phe Pro 
    1025                 1030                 1035             


Gln Leu  Gly Leu Arg Phe Leu  Gln Glu Leu Ser Glu  Thr Gln Leu 
    1040                 1045                 1050             


Arg Ala  Met Leu Pro Ala Leu  Gln Gly Ala Ser Val  Thr Pro Ala 
    1055                 1060                 1065             


Gln Ala  Val Leu Leu Phe Gly  Arg Leu Leu Pro Lys  His Asp Leu 
    1070                 1075                 1080             


Ser Leu  Glu Glu Leu Cys Ser  Leu His Pro Leu Leu  Pro Gly Leu 
    1085                 1090                 1095             


Ser Pro  Gln Thr Leu Gln Ala  Ile Pro Lys Arg Val  Leu Val Gly 
    1100                 1105                 1110             


Ala Cys  Ser Cys Leu Gly Pro  Glu Leu Ser Arg Leu  Ser Ala Cys 
    1115                 1120                 1125             


Gln Ile  Ala Ala Leu Leu Gln  Thr Phe Arg Val Lys  Asp Gly Val 
    1130                 1135                 1140             


Lys Asn  Met Gly Ala Ala Gly  Ala Gly Ser Ala Val  Cys Ile Pro 
    1145                 1150                 1155             


Gly Gln  Pro Thr Thr Trp Pro  Asp Cys Leu Leu Pro  Leu Leu Pro 
    1160                 1165                 1170             


Leu Lys  Leu Leu Gln Leu Asp  Ala Ala Ala Leu Leu  Ala Asn Arg 
    1175                 1180                 1185             


Arg Leu  Tyr Arg Gln Leu Pro  Trp Ser Glu Gln Gln  Ala Gln Phe 
    1190                 1195                 1200             


Leu Trp  Lys Lys Met Gln Val  Pro Thr Asn Leu Ser  Leu Arg Asn 
    1205                 1210                 1215             


Leu Gln  Ala Leu Gly Asn Leu  Ala Gly Gly Met Thr  Cys Glu Phe 
    1220                 1225                 1230             


Leu Gln  Gln Ile Ser Ser Met  Val Asp Phe Leu Asp  Val Val His 
    1235                 1240                 1245             


Met Leu  Tyr Gln Leu Pro Thr  Gly Val Arg Glu Ser  Leu Arg Ala 
    1250                 1255                 1260             


Cys Ile  Trp Thr Glu Leu Gln  Arg Arg Met Thr Met  Pro Glu Pro 
    1265                 1270                 1275             


Glu Leu  Thr Thr Leu Gly Pro  Glu Leu Ser Glu Leu  Asp Thr Lys 
    1280                 1285                 1290             


Leu Leu  Leu Asp Leu Pro Ile  Gln Leu Met Asp Arg  Leu Ser Asn 
    1295                 1300                 1305             


Asp Ser  Ile Met Leu Val Val  Glu Met Val Gln Gly  Ala Pro Glu 
    1310                 1315                 1320             


Gln Leu  Leu Ala Leu Thr Pro  Leu His Gln Thr Ala  Leu Ala Glu 
    1325                 1330                 1335             


Arg Ala  Leu Lys Asn Leu Ala  Pro Lys Glu Thr Pro  Ile Ser Lys 
    1340                 1345                 1350             


Glu Val  Leu Glu Thr Leu Gly  Pro Leu Val Gly Phe  Leu Gly Ile 
    1355                 1360                 1365             


Glu Ser  Thr Arg Arg Ile Pro  Leu Pro Ile Leu Leu  Ser His Leu 
    1370                 1375                 1380             


Ser Gln  Leu Gln Gly Phe Cys  Leu Gly Glu Thr Phe  Ala Thr Glu 
    1385                 1390                 1395             


Leu Gly  Trp Leu Leu Leu Gln  Glu Pro Val Leu Gly  Lys Pro Glu 
    1400                 1405                 1410             


Leu Trp  Ser Gln Asp Glu Ile  Glu Gln Ala Gly Arg  Leu Val Phe 
    1415                 1420                 1425             


Thr Leu  Ser Ala Glu Ala Ile  Ser Ser Ile Pro Arg  Glu Ala Leu 
    1430                 1435                 1440             


Gly Pro  Glu Thr Leu Glu Arg  Leu Leu Gly Lys His  Gln Ser Trp 
    1445                 1450                 1455             


Glu Gln  Ser Arg Val Gly His  Leu Cys Gly Glu Ser  Gln Leu Ala 
    1460                 1465                 1470             


His Lys  Lys Ala Ala Leu Val  Ala Gly Ile Val His  Pro Ala Ala 
    1475                 1480                 1485             


Glu Gly  Leu Gln Glu Pro Val  Pro Asn Cys Ala Asp  Ile Arg Gly 
    1490                 1495                 1500             


Thr Phe  Pro Ala Ala Trp Ser  Ala Thr Gln Ile Ser  Glu Met Glu 
    1505                 1510                 1515             


Leu Ser  Asp Phe Glu Asp Cys  Leu Ser Leu Phe Ala  Gly Asp Pro 
    1520                 1525                 1530             


Gly Leu  Gly Pro Glu Glu Leu  Arg Ala Ala Met Gly  Lys Ala Lys 
    1535                 1540                 1545             


Gln Leu  Trp Gly Pro Pro Arg  Gly Phe Arg Pro Glu  Gln Ile Leu 
    1550                 1555                 1560             


Gln Leu  Gly Arg Leu Leu Ile  Gly Leu Gly Glu Arg  Glu Leu Gln 
    1565                 1570                 1575             


Glu Leu  Thr Leu Val Asp Trp  Gly Val Leu Ser Ser  Leu Gly Gln 
    1580                 1585                 1590             


Ile Asp  Gly Trp Ser Ser Met  Gln Leu Arg Ala Val  Val Ser Ser 
    1595                 1600                 1605             


Phe Leu  Arg Gln Ser Gly Arg  His Val Ser His Leu  Asp Phe Ile 
    1610                 1615                 1620             


Tyr Leu  Thr Ala Leu Gly Tyr  Thr Val Cys Gly Leu  Arg Pro Glu 
    1625                 1630                 1635             


Glu Leu  Gln His Ile Ser Ser  Trp Glu Phe Ser Gln  Ala Ala Leu 
    1640                 1645                 1650             


Phe Leu  Gly Ser Leu His Leu  Pro Cys Ser Glu Glu  Gln Leu Glu 
    1655                 1660                 1665             


Val Leu  Ala Tyr Leu Leu Val  Leu Pro Gly Gly Phe  Gly Pro Val 
    1670                 1675                 1680             


Ser Asn  Trp Gly Pro Glu Ile  Phe Thr Glu Ile Gly  Thr Ile Ala 
    1685                 1690                 1695             


Ala Gly  Ile Pro Asp Leu Ala  Leu Ser Ala Leu Leu  Arg Gly Gln 
    1700                 1705                 1710             


Ile Gln  Gly Leu Thr Pro Leu  Ala Ile Ser Val Ile  Pro Ala Pro 
    1715                 1720                 1725             


Lys Phe  Ala Val Val Phe Asn  Pro Ile Gln Leu Ser  Ser Leu Thr 
    1730                 1735                 1740             


Arg Gly  Gln Ala Val Ala Val  Thr Pro Glu Gln Leu  Ala Tyr Leu 
    1745                 1750                 1755             


Ser Pro  Glu Gln Arg Arg Ala  Val Ala Trp Ala Gln  His Glu Gly 
    1760                 1765                 1770             


Lys Glu  Ile Pro Glu Gln Leu  Gly Arg Asn Ser Ala  Trp Gly Leu 
    1775                 1780                 1785             


Tyr Asp  Trp Phe Gln Ala Ser  Trp Ala Leu Ala Leu  Pro Val Ser 
    1790                 1795                 1800             


Ile Phe  Gly His Leu Leu 
    1805                 


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 28
<211> 8543
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
ccaatgatac gcgtcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg       60

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac      120

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta catcgacggt      180

atcgggggag ctcgcagggt ctccattttg aagcgggagg tttgaacgcg cagccgccat      240

gccggggttt tacgagattg tgattaaggt ccccagcgac cttgacgagc atctgcccgg      300

catttctgac agctttgtga actgggtggc cgagaaggaa tgggagttgc cgccagattc      360

tgacatggat ctgaatctga ttgagcaggc acccctgacc gtggccgaga agctgcagcg      420

cgactttctg acggaatggc gccgtgtgag taaggccccg gaggctcttt tctttgtgca      480

atttgagaag ggagagagct acttccacat gcacgtgctc gtggaaacca ccggggtgaa      540

atccatggtt ttgggacgtt tcctgagtca gattcgcgaa aaactgattc agagaattta      600

ccgcgggatc gagccgactt tgccaaactg gttcgcggtc acaaagacca gaaatggcgc      660

cggaggcggg aacaaggtgg tggatgagtg ctacatcccc aattacttgc tccccaaaac      720

ccagcctgag ctccagtggg cgtggactaa tatggaacag tatttaagcg cctgtttgaa      780

tctcacggag cgtaaacggt tggtggcgca gcatctgacg cacgtgtcgc agacgcagga      840

gcagaacaaa gagaatcaga atcccaattc tgatgcgccg gtgatcagat caaaaacttc      900

agccaggtac atggagctgg tcgggtggct cgtggacaag gggattacct cggagaagca      960

gtggatccag gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc     1020

ccaaatcaag gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc     1080

cgactacctg gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat     1140

tttggaacta aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac     1200

gaaaaagttc ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac     1260

caacatcgcg gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa     1320

tgagaacttt cccttcaacg actgtgtgga caagatggtg atctggtggg aggaggggaa     1380

gatgaccgcc aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt     1440

ggaccagaaa tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa     1500

caccaatatg tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt     1560

gcaagaccgg atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt     1620

caccaagcag gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga     1680

gcatgaattc tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga     1740

tataagtgag cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga     1800

agcttcgatc aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa     1860

tctgatgctg tttccctgca gacaatgcga gagactgaat cagaattcaa atatctgctt     1920

cactcacggt gtcaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc     1980

tgtcgtcaaa aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc     2040

agacgcttgc actgcttgcg acctggtcaa tgtggacttg gatgactgtg tttctgaaca     2100

ataaatgact taaaccaggt atgagtcggc tggataaatc taaagtcata aacggcgctc     2160

tggaattact caatgaagtc ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc     2220

tgggagttga gcagcctacc ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg     2280

ccctggccat cgagatgctg gacaggcatc atacccactt ctgccccctg gaaggcgagt     2340

catggcaaga ctttctgcgg aacaacgcca agtcattccg ctgtgctctc ctctcacatc     2400

gcgacggggc taaagtgcat ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg     2460

aaaatcagct cgcgttcctg tgtcagcaag gcttctccct ggagaacgca ctgtacgctc     2520

tgtccgccgt gggccacttt acactgggct gcgtattgga ggaacaggag catcaagtag     2580

caaaagagga aagagagaca cctaccaccg attctatgcc cccacttctg agacaagcaa     2640

ttgagctgtt cgaccggcag ggagccgaac ctgccttcct tttcggcctg gaactaatca     2700

tatgtggcct ggagaaacag ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg     2760

attttgactt agacatgctc ccagccgatg cccttgacga ctttgacctt gatatgctgc     2820

ctgctgacgc tcttgacgat tttgaccttg acatgctccc cgggtaaatg catgaattcg     2880

atctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga tcagcctcga     2940

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3000

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3060

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3120

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     3180

gaaccagctg gggctcgaat caagctatca agtgccacct gacgtctccc tatcagtgat     3240

agagaagtcg acacgtctcg agctccctat cagtgataga gaaggtacgt ctagaacgtc     3300

tccctatcag tgatagagaa gtcgacacgt ctcgagctcc ctatcagtga tagagaaggt     3360

acgtctagaa cgtctcccta tcagtgatag agaagtcgac acgtctcgag ctccctatca     3420

gtgatagaga aggtacgtct agaacgtctc cctatcagtg atagagaagt cgacacgtct     3480

cgagctccct atcagtgata gagaaggtac cccctatata agcagagaga tctgttcaaa     3540

tttgaactga ctaagcggct cccgccagat tttggcaaga ttactaagca ggaagtcaag     3600

gacttttttg cttgggcaaa ggtcaatcag gtgccggtga ctcacgagtt taaagttccc     3660

agggaattgg cgggaactaa aggggcggag aaatctctaa aacgcccact gggtgacgtc     3720

accaatacta gctataaaag tctggagaag cgggccaggc tctcatttgt tcccgagacg     3780

cctcgcagtt cagacgtgac tgttgatccc gctcctctgc gaccgctagc ttcgatcaac     3840

tacgcagaca ggtaccaaaa caagtgttct cgtcacgtgg gcattaatct gattctgttt     3900

ccctgcagac aatgcgagag aatgaatcag aactcaaata tctgcttcac tcacggacag     3960

aaagactgtt tagagtgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcaaaaag     4020

gcgtatcaga aactgtgcta cattcatcat atcatgggaa aggtgccaga cgcttgcact     4080

gcctgcgatc tggtcaatgt ggatttggat gactgcatct ttgaacaata aatgacttaa     4140

gccaggtatg gctgccgatg gttatcttcc agattggctc gaggacaacc ttagtgaagg     4200

aattcgcgag tggtgggctt tgaaacctgg agcccctcaa cccaaggcaa atcaacaaca     4260

tcaagacaac gctagaggtc ttgtgcttcc gggttacaaa taccttggac ccggcaacgg     4320

actcgacaag ggggagccgg tcaacgcagc agacgcggcg gccctcgagc acgacaaagc     4380

ctacgaccag cagctcaagg ccggagacaa cccgtacctc aagtacaacc acgccgacgc     4440

cgagttccag gagcggctca aagaagatac gtcttttggg ggcaacctcg ggcgagcagt     4500

cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg gttgaggaag cggctaagac     4560

ggctcctgga aagaagaggc ctgtagagca gtctcctcag gaaccggact cctccgcggg     4620

tattggcaaa tcgggtgcac agcccgctaa aaagagactc aatttcggtc agactggcga     4680

cacagagtca gtcccagacc ctcaaccaat cggagaacct cccgcagccc cctcaggtgt     4740

gggatctctt acaatggctt caggtggtgg cgcaccagtg gcagacaata acgaaggtgc     4800

cgatggagtg ggtagttcct cgggaaattg gcattgcgat tcccaatggc tgggggacag     4860

agtcatcacc accagcaccc gaacctgggc cctgcccacc tacaacaatc acctctacaa     4920

gcaaatctcc aacagcacat ctggaggatc ttcaaatgac aacgcctact tcggctacag     4980

caccccctgg gggtattttg acttcaacag attccactgc cacttctcac cacgtgactg     5040

gcagcgactc atcaacaaca actggggatt ccggcctaag cgactcaact tcaagctctt     5100

taacattcag gtcaaagagg ttacggacaa caatggagtc aagaccatcg ccaataacct     5160

taccagcacg gtccaggtct tcacggactc agactatcag ctcccgtacg tgctcgggtc     5220

ggctcacgag ggctgcctcc cgccgttccc agcggacgtt ttcatgattc ctcagtacgg     5280

gtatctgacg cttaatgatg gaagccaggc cgtgggtcgt tcgtcctttt actgcctgga     5340

atatttcccg tcgcaaatgc taagaacggg taacaacttc cagttcagct acgagtttga     5400

gaacgtacct ttccatagca gctacgctca cagccaaagc ctggaccgac taatgaatcc     5460

actcatcgac caatacttgt actatctctc tagaactatt aacggttctg gacagaatca     5520

acaaacgcta aaattcagtg tggccggacc cagcaacatg gctgtccagg gaagaaacta     5580

catacctgga cccagctacc gacaacaacg tgtctcaacc actgtgactc aaaacaacaa     5640

cagcgaattt gcttggcctg gagcttcttc ttgggctctc aatggacgta atagcttgat     5700

gaatcctgga cctgctatgg cctctcacaa agaaggagag gaccgtttct ttcctttgtc     5760

tggatcttta atttttggca aacaaggtac tggcagagac aacgtggatg cggacaaagt     5820

catgataacc aacgaagaag aaattaaaac tactaacccg gtagcaacgg agtcctatgg     5880

acaagtggcc acaaaccacc agagtgccca aactttggcg gtgcctttta aggcacaggc     5940

gcagaccggt tgggttcaaa accaaggaat acttccgggt atggtttggc aggacagaga     6000

tgtgtacctg caaggaccca tttgggccaa aattcctcac acggacggca actttcaccc     6060

ttctccgctg atgggagggt ttggaatgaa gcacccgcct cctcagatcc tcatcaaaaa     6120

cacacctgta cctgcggatc ctccaacggc cttcaacaag gacaagctga actctttcat     6180

cacccagtat tctactggtc aagtcagcgt ggagatcgag tgggagctgc agaaggaaaa     6240

cagcaagcgc tggaacccgg agatccagta cacttccaac tattacaagt ctaataatgt     6300

tgaatttgct gttaatactg aaggtgtata tagtgaaccc cgccccattg gcaccagata     6360

cctgactcgt aatctgtaag tcgacttgct tgttaatcaa taaaccgttt aattcgtttc     6420

agttgaactt tggtctctgc gaagggcaat tcgtttaaac ctgcaggact agaggtcctg     6480

tattagaggt cacgtgagtg ttttgcgaca ttttgcgaca ccatgtggtc acgctgggta     6540

tttaagcccg agtgagcacg cagggtctcc attttgaagc gggaggtttg aacgcgcagc     6600

cgccaagccg aattctgcag atatcacatg tcctaggaac tatcgatcca tcacactggc     6660

ggccgctcga ctagagcggc cgccaccgcg gtggagctcc agcttttgcg gaccgaatcg     6720

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     6780

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     6840

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     6900

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     6960

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     7020

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     7080

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     7140

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     7200

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     7260

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     7320

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     7380

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     7440

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     7500

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     7560

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     7620

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     7680

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     7740

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     7800

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     7860

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     7920

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     7980

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     8040

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     8100

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     8160

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     8220

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     8280

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     8340

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     8400

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     8460

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     8520

cccgaaaagt gccacctgac gtc                                             8543


<210> 29
<211> 5262
<212> DNA
<213> Homo sapiens

<400> 29
gtgactctgg cccctactgg gcctcattcc ctggaccctg gtctctcctt cctgaagtca       60

ttgctctcca ctctggacca ggctccccag ggctccctga gccgctcacg gttctttaca      120

ttcctggcca acatttcttc ttcctttgag cctgggagaa tgggggaagg accagtagga      180

gagcccccac ctctccagcc gcctgctctg cggctccatg attttctagt gacactgaga      240

ggtagccccg actgggagcc aatgctaggg ctgctagggg atatgctggc actgctggga      300

caggagcaga ctccccgaga tttcctggtg caccaggcag gggtgctggg tggacttgtg      360

gaggtgctgc tgggagcctt agttcctggg ggccccccta ccccaactcg gcccccatgc      420

acccgtgatg ggccgtctga ctgtgtcctg gctgctgact ggttgccttc tctgctgctg      480

ttgttagagg gcacacgctg gcaagctctg gtgcaggtgc agcccagtgt ggaccccacc      540

aatgccacag gcctcgatgg gagggaggca gctcctcact ttttgcaggg tctgttgggt      600

ttgcttaccc caacagggga gctaggctcc aaggaggctc tttggggcgg tctgctacgc      660

acagtggggg cccccctcta tgctgccttt caggaggggc tgctccgtgt cactcactcc      720

ctgcaggatg aggtcttctc cattttgggg cagccagagc ctgataccaa tgggcagtgc      780

cagggaggta accttcaaca gctgctctta tggggcgtcc ggcacaacct ttcctgggat      840

gtccaggcgc tgggctttct gtctggatca ccacccccac cccctgccct ccttcactgc      900

ctgagcacgg gcgtgcctct gcccagagct tctcagccgt cagcccacat cagcccacgc      960

caacggcgag ccatcactgt ggaggccctc tgtgagaacc acttaggccc agcaccaccc     1020

tacagcattt ccaacttctc catccacttg ctctgccagc acaccaagcc tgccactcca     1080

cagccccatc ccagcaccac tgccatctgc cagacagctg tgtggtatgc agtgtcctgg     1140

gcaccaggtg cccaaggctg gctacaggcc tgccacgacc agtttcctga tgagtttttg     1200

gatgcgatct gcagtaacct ctccttttca gccctgtctg gctccaaccg ccgcctggtg     1260

aagcggctct gtgctggcct gctcccaccc cctaccagct gccctgaagg cctgccccct     1320

gttcccctca ccccagacat cttttggggc tgcttcttgg agaatgagac tctgtgggct     1380

gagcgactgt gtggggaggc aagtctacag gctgtgcccc ccagcaacca ggcttgggtc     1440

cagcatgtgt gccagggccc caccccagat gtcactgcct ccccaccatg ccacattgga     1500

ccctgtgggg aacgctgccc ggatgggggc agcttcctgg tgatggtctg tgccaatgac     1560

accatgtatg aggtcctggt gcccttctgg ccttggctag caggccaatg caggataagt     1620

cgtgggggca atgacacttg cttcctagaa gggctgctgg gcccccttct gccctctctg     1680

ccaccactgg gaccatcccc actctgtctg acccctggcc ccttcctcct tggcatgcta     1740

tcccagttgc cacgctgtca gtcctctgtc ccagctcttg ctcaccccac acgcctacac     1800

tatctcctcc gcctgctgac cttcctcttg ggtccagggg ctgggggcgc tgaggcccag     1860

gggatgctgg gtcgggccct actgctctcc agtctcccag acaactgctc cttctgggat     1920

gcctttcgcc cagagggccg gcgcagtgtg ctacggacga ttggggaata cctggaacaa     1980

gatgaggagc agccaacccc atcaggcttt gaacccactg tcaaccccag ctctggtata     2040

agcaagatgg agctgctggc ctgctttagt cctgtgctgt gggatctgct ccagagggaa     2100

aagagtgttt gggccctgca gattctagtg caggcgtacc tgcatatgcc cccagaaaac     2160

ctccagcagc tggtgctttc agcagagagg gaggctgcac agggcttcct gacactcatg     2220

ctgcagggga agctgcaggg gaagctgcag gtaccaccat ccgaggagca ggccctgggt     2280

cgcctgacag ccctgctgct ccagcggtac ccacgcctca cctcccagct cttcattgac     2340

ctgtcaccac tcatcccttt cttggctgtc tctgacctga tgcgcttccc accatccctg     2400

ttagccaacg acagtgtcct ggctgccatc cgggattaca gcccaggaat gaggcctgaa     2460

cagaaggagg ctctggcaaa gcgactgctg gcccctgaac tgtttgggga agtgcctgcc     2520

tggccccagg agctgctgtg ggcagtgctg cccctgctcc cccacctccc tctggagaac     2580

tttttgcagc tcagccctca ccagatccag gccctggagg atagctggcc agcagcaggt     2640

ctggggccag ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggat     2700

ggtgaggagc aggtacgcag gcttgggccc ctcgcctgtt tcctgagccc tgaggagctg     2760

cagagcctag tgcccctgag tgatccaacg gggccagtag aacgggggct gctggaatgt     2820

gcagccaatg ggaccctcag cccagaagga cgggtggcat atgaacttct gggtgtgttg     2880

cgctcatctg gaggagcggt gctgagcccc cgggagctgc gggtctgggc ccctctcttc     2940

tctcagctgg gcctccgctt ccttcaggag ctgtcagagc cccagcttag agccatgctt     3000

cctgtcctgc agggaactag tgttacacct gctcaggctg tcctgctgct tggacggctc     3060

cttcctaggc acgatctatc cctggaggaa ctctgctcct tgcaccttct gctaccaggc     3120

ctcagccccc agacactcca ggccatccct aggcgagtcc tggtcggggc ttgttcctgc     3180

ctggcccctg aactgtcacg cctctcagcc tgccagaccg cagcactgct gcagaccttt     3240

cgggttaaag atggtgttaa aaatatgggt acaacaggtg ctggtccagc tgtgtgtatc     3300

cctggtcagc ctattcccac cacctggcca gactgcctgc ttcccctgct cccattaaag     3360

ctgctacaac tggattcctt ggctcttctg gcaaatcgaa gacgctactg ggagctgccc     3420

tggtctgagc agcaggcaca gtttctctgg aagaagatgc aagtacccac caaccttacc     3480

ctcaggaatc tgcaggctct gggcaccctg gcaggaggca tgtcctgtga gtttctgcag     3540

cagatcaact ccatggtaga cttccttgaa gtggtgcaca tgatctatca gctgcccact     3600

agagttcgag ggagcctgag ggcctgtatc tgggcagagc tacagcggag gatggcaatg     3660

ccagaaccag aatggacaac tgtagggcca gaactgaacg ggctggatag caagctactc     3720

ctggacttac cgatccagtt gatggacaga ctatccaatg aatccattat gttggtggtg     3780

gagctggtgc aaagagctcc agagcagctg ctggcactga cccccctcca ccaggcagcc     3840

ctggcagaga gggcactaca aaacctggct ccaaaggaga ctccagtctc aggggaagtg     3900

ctggagacct taggcccttt ggttggattc ctggggacag agagcacacg acagatcccc     3960

ctacagatcc tgctgtccca tctcagtcag ctgcaaggct tctgcctagg agagacattt     4020

gccacagagc tgggatggct gctattgcag gagtctgttc ttgggaaacc agagttgtgg     4080

agccaggatg aagtagagca agctggacgc ctagtattca ctctgtctac tgaggcaatt     4140

tccttgatcc ccagggaggc cttgggtcca gagaccctgg agcggcttct agaaaagcag     4200

cagagctggg agcagagcag agttggacag ctgtgtaggg agccacagct tgctgccaag     4260

aaagcagccc tggtagcagg ggtggtgcga ccagctgctg aggatcttcc agaacctgtg     4320

ccaaattgtg cagatgtacg agggacattc ccagcagcct ggtctgcaac ccagattgca     4380

gagatggagc tctcagactt tgaggactgc ctgacattat ttgcaggaga cccaggactt     4440

gggcctgagg aactgcgggc agccatgggc aaagcaaaac agttgtgggg tcccccccgg     4500

ggatttcgtc ctgagcagat cctgcagctt ggtaggctct taataggtct aggagatcgg     4560

gaactacagg agctgatcct agtggactgg ggagtgctga gcaccctggg gcagatagat     4620

ggctggagca ccactcagct ccgcattgtg gtctccagtt tcctacggca gagtggtcgg     4680

catgtgagcc acctggactt cgttcatctg acagcgctgg gttatactct ctgtggactg     4740

cggccagagg agctccagca catcagcagt tgggagttca gccaagcagc tctcttcctc     4800

ggcaccctgc atctccagtg ctctgaggaa caactggagg ttctggccca cctacttgta     4860

ctgcctggtg ggtttggccc aatcagtaac tgggggcctg agatcttcac tgaaattggc     4920

accatagcag ctgggatccc agacctggct ctttcagcac tgctgcgggg acagatccag     4980

ggcgttactc ctcttgccat ttctgtcatc cctcctccta aatttgctgt ggtgtttagt     5040

cccatccaac tatctagtct caccagtgct caggctgtgg ctgtcactcc tgagcaaatg     5100

gcctttctga gtcctgagca gcgacgagca gttgcatggg cccaacatga gggaaaggag     5160

agcccagaac agcaaggtcg aagtacagcc tggggcctcc aggactggtc acgaccttcc     5220

tggtccctgg tattgactat cagcttcctt ggccacctgc ta                        5262


<210> 30
<211> 5515
<212> DNA
<213> Homo sapiens

<400> 30
gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac       60

cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg      120

ctgctgctgc tgtcctttgc agtgactctg gcccctactg ggcctcattc cctggaccct      180

ggtctctcct tcctgaagtc attgctctcc actctggacc aggctcccca gggctccctg      240

agccgctcac ggttctttac attcctggcc aacatttctt cttcctttga gcctgggaga      300

atgggggaag gaccagtagg agagccccca cctctccagc cgcctgctct gcggctccat      360

gattttctag tgacactgag aggtagcccc gactgggagc caatgctagg gctgctaggg      420

gatatgctgg cactgctggg acaggagcag actccccgag atttcctggt gcaccaggca      480

ggggtgctgg gtggacttgt ggaggtgctg ctgggagcct tagttcctgg gggcccccct      540

accccaactc ggcccccatg cacccgtgat gggccgtctg actgtgtcct ggctgctgac      600

tggttgcctt ctctgctgct gttgttagag ggcacacgct ggcaagctct ggtgcaggtg      660

cagcccagtg tggaccccac caatgccaca ggcctcgatg ggagggaggc agctcctcac      720

tttttgcagg gtctgttggg tttgcttacc ccaacagggg agctaggctc caaggaggct      780

ctttggggcg gtctgctacg cacagtgggg gcccccctct atgctgcctt tcaggagggg      840

ctgctccgtg tcactcactc cctgcaggat gaggtcttct ccattttggg gcagccagag      900

cctgatacca atgggcagtg ccagggaggt aaccttcaac agctgctctt atggggcgtc      960

cggcacaacc tttcctggga tgtccaggcg ctgggctttc tgtctggatc accaccccca     1020

ccccctgccc tccttcactg cctgagcacg ggcgtgcctc tgcccagagc ttctcagccg     1080

tcagcccaca tcagcccacg ccaacggcga gccatcactg tggaggccct ctgtgagaac     1140

cacttaggcc cagcaccacc ctacagcatt tccaacttct ccatccactt gctctgccag     1200

cacaccaagc ctgccactcc acagccccat cccagcacca ctgccatctg ccagacagct     1260

gtgtggtatg cagtgtcctg ggcaccaggt gcccaaggct ggctacaggc ctgccacgac     1320

cagtttcctg atgagttttt ggatgcgatc tgcagtaacc tctccttttc agccctgtct     1380

ggctccaacc gccgcctggt gaagcggctc tgtgctggcc tgctcccacc ccctaccagc     1440

tgccctgaag gcctgccccc tgttcccctc accccagaca tcttttgggg ctgcttcttg     1500

gagaatgaga ctctgtgggc tgagcgactg tgtggggagg caagtctaca ggctgtgccc     1560

cccagcaacc aggcttgggt ccagcatgtg tgccagggcc ccaccccaga tgtcactgcc     1620

tccccaccat gccacattgg accctgtggg gaacgctgcc cggatggggg cagcttcctg     1680

gtgatggtct gtgccaatga caccatgtat gaggtcctgg tgcccttctg gccttggcta     1740

gcaggccaat gcaggataag tcgtgggggc aatgacactt gcttcctaga agggctgctg     1800

ggcccccttc tgccctctct gccaccactg ggaccatccc cactctgtct gacccctggc     1860

cccttcctcc ttggcatgct atcccagttg ccacgctgtc agtcctctgt cccagctctt     1920

gctcacccca cacgcctaca ctatctcctc cgcctgctga ccttcctctt gggtccaggg     1980

gctgggggcg ctgaggccca ggggatgctg ggtcgggccc tactgctctc cagtctccca     2040

gacaactgct ccttctggga tgcctttcgc ccagagggcc ggcgcagtgt gctacggacg     2100

attggggaat acctggaaca agatgaggag cagccaaccc catcaggctt tgaacccact     2160

gtcaacccca gctctggtat aagcaagatg gagctgctgg cctgctttag tcctgtgctg     2220

tgggatctgc tccagaggga aaagagtgtt tgggccctgc agattctagt gcaggcgtac     2280

ctgcatatgc ccccagaaaa cctccagcag ctggtgcttt cagcagagag ggaggctgca     2340

cagggcttcc tgacactcat gctgcagggg aagctgcagg ggaagctgca ggtaccacca     2400

tccgaggagc aggccctggg tcgcctgaca gccctgctgc tccagcggta cccacgcctc     2460

acctcccagc tcttcattga cctgtcacca ctcatccctt tcttggctgt ctctgacctg     2520

atgcgcttcc caccatccct gttagccaac gacagtgtcc tggctgccat ccgggattac     2580

agcccaggaa tgaggcctga acagaaggag gctctggcaa agcgactgct ggcccctgaa     2640

ctgtttgggg aagtgcctgc ctggccccag gagctgctgt gggcagtgct gcccctgctc     2700

ccccacctcc ctctggagaa ctttttgcag ctcagccctc accagatcca ggccctggag     2760

gatagctggc cagcagcagg tctggggcca gggcatgccc gccatgtgct gcgcagcctg     2820

gtaaaccaga gtgtccagga tggtgaggag caggtacgca ggcttgggcc cctcgcctgt     2880

ttcctgagcc ctgaggagct gcagagccta gtgcccctga gtgatccaac ggggccagta     2940

gaacgggggc tgctggaatg tgcagccaat gggaccctca gcccagaagg acgggtggca     3000

tatgaacttc tgggtgtgtt gcgctcatct ggaggagcgg tgctgagccc ccgggagctg     3060

cgggtctggg cccctctctt ctctcagctg ggcctccgct tccttcagga gctgtcagag     3120

ccccagctta gagccatgct tcctgtcctg cagggaacta gtgttacacc tgctcaggct     3180

gtcctgctgc ttggacggct ccttcctagg cacgatctat ccctggagga actctgctcc     3240

ttgcaccttc tgctaccagg cctcagcccc cagacactcc aggccatccc taggcgagtc     3300

ctggtcgggg cttgttcctg cctggcccct gaactgtcac gcctctcagc ctgccagacc     3360

gcagcactgc tgcagacctt tcgggttaaa gatggtgtta aaaatatggg tacaacaggt     3420

gctggtccag ctgtgtgtat ccctggtcag cctattccca ccacctggcc agactgcctg     3480

cttcccctgc tcccattaaa gctgctacaa ctggattcct tggctcttct ggcaaatcga     3540

agacgctact gggagctgcc ctggtctgag cagcaggcac agtttctctg gaagaagatg     3600

caagtaccca ccaaccttac cctcaggaat ctgcaggctc tgggcaccct ggcaggaggc     3660

atgtcctgtg agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcac     3720

atgatctatc agctgcccac tagagttcga gggagcctga gggcctgtat ctgggcagag     3780

ctacagcgga ggatggcaat gccagaacca gaatggacaa ctgtagggcc agaactgaac     3840

gggctggata gcaagctact cctggactta ccgatccagt tgatggacag actatccaat     3900

gaatccatta tgttggtggt ggagctggtg caaagagctc cagagcagct gctggcactg     3960

acccccctcc accaggcagc cctggcagag agggcactac aaaacctggc tccaaaggag     4020

actccagtct caggggaagt gctggagacc ttaggccctt tggttggatt cctggggaca     4080

gagagcacac gacagatccc cctacagatc ctgctgtccc atctcagtca gctgcaaggc     4140

ttctgcctag gagagacatt tgccacagag ctgggatggc tgctattgca ggagtctgtt     4200

cttgggaaac cagagttgtg gagccaggat gaagtagagc aagctggacg cctagtattc     4260

actctgtcta ctgaggcaat ttccttgatc cccagggagg ccttgggtcc agagaccctg     4320

gagcggcttc tagaaaagca gcagagctgg gagcagagca gagttggaca gctgtgtagg     4380

gagccacagc ttgctgccaa gaaagcagcc ctggtagcag gggtggtgcg accagctgct     4440

gaggatcttc cagaacctgt gccaaattgt gcagatgtac gagggacatt cccagcagcc     4500

tggtctgcaa cccagattgc agagatggag ctctcagact ttgaggactg cctgacatta     4560

tttgcaggag acccaggact tgggcctgag gaactgcggg cagccatggg caaagcaaaa     4620

cagttgtggg gtcccccccg gggatttcgt cctgagcaga tcctgcagct tggtaggctc     4680

ttaataggtc taggagatcg ggaactacag gagctgatcc tagtggactg gggagtgctg     4740

agcaccctgg ggcagataga tggctggagc accactcagc tccgcattgt ggtctccagt     4800

ttcctacggc agagtggtcg gcatgtgagc cacctggact tcgttcatct gacagcgctg     4860

ggttatactc tctgtggact gcggccagag gagctccagc acatcagcag ttgggagttc     4920

agccaagcag ctctcttcct cggcaccctg catctccagt gctctgagga acaactggag     4980

gttctggccc acctacttgt actgcctggt gggtttggcc caatcagtaa ctgggggcct     5040

gagatcttca ctgaaattgg caccatagca gctgggatcc cagacctggc tctttcagca     5100

ctgctgcggg gacagatcca gggcgttact cctcttgcca tttctgtcat ccctcctcct     5160

aaatttgctg tggtgtttag tcccatccaa ctatctagtc tcaccagtgc tcaggctgtg     5220

gctgtcactc ctgagcaaat ggcctttctg agtcctgagc agcgacgagc agttgcatgg     5280

gcccaacatg agggaaagga gagcccagaa cagcaaggtc gaagtacagc ctggggcctc     5340

caggactggt cacgaccttc ctggtccctg gtattgacta tcagcttcct tggccacctg     5400

ctatgagcct gtctctacag tagaaggaga ttgtggggag agaaatctta agtcataatg     5460

aataaagtgc aaacagaagt gcatcctgat tattttcaga agctgatgag gaata          5515


<210> 31
<211> 5361
<212> DNA
<213> Mus musculus

<400> 31
gcccctactg ggcctcagtc tttggatgct ggtctctccc ttctgaagtc attcgtagcc       60

actctggacc aagctcctca gcgttccctc agccagtcac ggttctctgc gttcctggcc      120

aacatttctt catccttcca gcttgggagg atgggggagg gaccggtggg agagccccca      180

cctctccagc cccctgcact tcgacttcat gatttcctcg tgacactgag aggtagccca      240

gactgggagc caatgctagg gcttctggga gatgtgctgg cactcctggg acaggaacag      300

actccccggg actttttggt gcaccaggca ggtgtactgg gtggacttgt agaggcattg      360

ttgggagcgt tagttcctgg aggcccccct gcccccactc gacccccatg cacccgtgat      420

ggcccttctg actgtgtcct ggctgctgat tggttgcctt ctctgatgtt gttattagag      480

ggtacacgct ggcaggccct ggtgcagttg cagcccagtg tggacccaac caatgccaca      540

ggtcttgatg gtagagagcc agctcctcac tttttacagg gtctgctggg cttgcttacc      600

ccagcaggag agttgggctc tgaggaggct ctttggggtg gtctgctgcg cacagtgggg      660

gcccccctct atgctgcctt ccaggagggg ctactgcgag tcactcattc tctgcaagat      720

gaggtctttt ctattatggg acagccagag cctgatgcca gtgggcagtg ccagggaggc      780

aaccttcaac agctgctttt atggggcatg cggaacaacc tttcttggga cgcccgagca      840

ctgggttttc tatctggatc accacctcca ccccctgctc tcctgcactg cctgagcaga      900

ggtgtgcctc tgcccagggc ttcccagcct gcggctcaca tcagccctcg acagcggcga      960

gccatctctg tggaggccct ctgcgagaac cactcaggcc cagagccacc ctacagcatc     1020

tccaacttct ccatctactt gctctgccag cacatcaagc ctgccacccc gcggccccct     1080

cctaccaccc cacggcctcc tcctaccacc ccacagcccc ctcctaccac tacacagccc     1140

attcctgaca ctacacagcc ccctcctgtc accccaaggc ctcctcctac caccccacaa     1200

ccccctccta gcacagctgt catctgccag acagctgtat ggtacgcagt ctcgtgggca     1260

ccaggtgccc gaggttggct ccaagcctgc catgatcagt ttcctgatca atttctggat     1320

atgatctgcg gcaacctctc attttcagcc ctgtctggcc ccagtcgtcc tttggtaaag     1380

cagctctgtg ctggcttgct cccacccccc actagctgtc caccaggcct gatccctgtg     1440

cccctcaccc cagaaatatt ctggggctgt ttcctggaga atgagacact gtgggctgaa     1500

cggttgtgtg tggaggacag tctgcaggct gtgcccccga ggaaccaggc ttgggttcag     1560

catgtgtgtc ggggccccac cttggacgcc actgattttc caccgtgccg cgttggaccc     1620

tgtggggaac gctgcccaga tgggggcagc ttcctgctca tggtctgtgc caatgacact     1680

ctgtatgaag ccttggttcc cttctgggct tggctagcag gccaatgcag aattagtcgt     1740

ggaggaaatg atacttgctt tctagaaggc atgctgggcc ccttgttgcc ctctctgccc     1800

cctctgggac catccccact ctgtctggct cctggtcctt ttctgcttgg catgttatcc     1860

cagttgccac gctgtcagtc ctccgtgcca gccctcgccc accccacgcg cctacattac     1920

ctcctgcgcc tactgacctt ccttctgggt ccagggactg ggggtgccga gacgcagggg     1980

atgttaggtc aagccctgct gctctctagt ctcccagaca actgttcatt ctgggatgcc     2040

ttccgcccag agggccggag aagtgtactg aggacagtcg gagagtactt gcagcgggaa     2100

gagccaaccc caccaggctt agactcctcc ctcagcctcg gctctggtat gagcaagatg     2160

gagcttctgt cctgcttcag tcctgtactg tgggatctac tccagagaga gaagagcgtt     2220

tgggccctga ggaccctggt gaaggcctac ctgcgcatgc ctccagaaga ccttcagcag     2280

cttgtgcttt cagcagagat ggaggctgca cagggcttcc tgacgctcat gcttcgttcc     2340

tgggctaagc tgaaggttca accatccgag gagcaggcca tgggccgcct gacagccttg     2400

ctgctccagc ggtacccacg cctcacctcc caactcttta tcgacatgtc accgctcatc     2460

cccttcctgg ctgtccctga cctcatgcgc ttcccaccgt cccttttggc caacgacagt     2520

gtcctggctg ccatcaggga tcacagctca ggaatgaagc ctgaacagaa ggaggccctg     2580

gcaaaacgac tgctggcccc tgagctgttt ggagaagtgc ctgattggcc ccaggagctg     2640

ctgtgggcag ccctgcctct gcttccccat ctgcctctgg agagctttct ccagctcagc     2700

cctcaccaga tccaggccct ggaggatagc tggccagtag cagatcttgg gccgggacac     2760

gcccgacatg tgcttcgtag cctagtaaac cagagcatgg aggatgggga ggagcaggtg     2820

ctcaggcttg ggtccctcgc ctgtttcctg agtcctgagg agctacagag tctggtgccc     2880

ttgagtgatc caatggggcc tgtagaacag ggtctgctgg aatgtgcggc caatgggacc     2940

ctcagcccag aaggacgggt ggcatatgaa cttctgggag tgttgcgttc atctggagga     3000

actgtcttaa gcccccgaga gctgagggtc tgggcacctc tctttcccca gctgggcctc     3060

cgcttcctgc aggagctctc agagacccag cttagagcca tgcttcctgc cctacaggga     3120

gccagtgtca cacctgccca ggctgttctg ttgtttggaa ggctccttcc taagcatgat     3180

ctgtccctgg aggaactctg ctccctgcac cctctcctgc caggtctcag cccccagaca     3240

ctccaggcca tccctaagag agttctggtt ggtgcttgtt cctgcctggg ccctgaactg     3300

tcaaggcttt cagcttgcca gattgcagct ctgctgcaga cctttcgggt aaaagatggt     3360

gttaaaaata tgggtgcagc aggtgccggc tcagccgtgt gcattcctgg gcagcccacc     3420

acttggccag actgcctgct tcccctgctc ccattaaagc tgctacagct ggacgctgca     3480

gctcttctgg caaaccgaag actctatcgg cagctgcctt ggtctgagca acaggcacag     3540

tttctctgga agaaaatgca agtgcctacc aacctgagcc tgaggaatct gcaggctctg     3600

ggcaacttgg caggaggcat gacctgcgag tttctgcagc agatcagctc aatggttgac     3660

tttcttgatg tggtacacat gctctaccag ctgcccactg gtgttcgaga gagcctgcgg     3720

gcctgtatct ggacagagct acagcggagg atgacaatgc cagagccaga gctgaccacc     3780

ctagggccag aactgagtga acttgacaca aagctactcc tggacttgcc gatccagctg     3840

atggacagat tgtccaatga ttccattatg ttggtggtgg agatggtcca aggcgctcca     3900

gagcagctgc tggcactgac cccactccac cagacagcct tggcagagcg agcacttaaa     3960

aacctggctc caaaggagac cccaatctcc aaagaagtgc tggagacact gggccccttg     4020

gttggattcc tgggaataga gagcacgcga cggatccctt tacccattct actgtctcat     4080

ctcagtcagc tgcagggctt ctgcctagga gagacatttg ccacagagct gggatggctg     4140

ctgttgcagg agcctgttct tggaaaacca gaattgtgga gccaggatga aatagagcaa     4200

gctggacgcc tagtattcac tctgtctgct gaggctattt cctcgatccc cagggaggct     4260

ttgggcccag agacactgga gaggcttctg ggaaagcatc aaagctggga gcagagcaga     4320

gtgggccatc tgtgtgggga gtcacagctt gcccacaaga aagcagctct ggtagctggg     4380

attgtgcatc cagctgctga gggtctccaa gagcctgtac caaactgtgc agacatacgg     4440

ggaaccttcc cagcggcctg gtctgcgaca caaatctcag agatggaact ctcagacttt     4500

gaagactgcc tgtcactatt tgctggagat ccaggacttg gtcctgagga actacgggca     4560

gccatgggca aggccaagca gttgtggggt ccccctcgag gattccgtcc tgagcagatc     4620

ttgcagctgg gccgtctcct gataggtcta ggagaacggg aactgcagga gcttaccttg     4680

gtggactggg gtgtgctgag cagcctgggg caaatagatg gctggagttc catgcagctc     4740

cgagccgtgg tctccagttt cctaaggcag agtggtcggc atgtgagcca cctggacttc     4800

atttatctga cagcactggg ttacacagtc tgtggattgc gaccagagga gttacagcac     4860

atcagcagtt gggagtttag ccaagcagct ctcttcctgg gtagcttgca tctcccgtgc     4920

tctgaggaac agctggaagt tctggcctat ctccttgtgt tgcctggtgg ctttggccca     4980

gtcagtaact gggggcctga gatcttcact gaaattggca caatagcagc tggcatccca     5040

gacctggctc tttcagcatt actgcgggga cagatccaag gcctgactcc tcttgccatt     5100

tctgtcattc ctgctcccaa gtttgcagtg gtcttcaacc ccatccagtt atctagtctc     5160

accaggggtc aggccgtagc tgttactcct gaacagctgg cctatctgag tcctgagcag     5220

cggcgagcag ttgcatgggc ccaacacgaa gggaaggaga tcccagagca gctgggtcga     5280

aactcagcct ggggtctcta cgactggttc caagcctcct gggccctggc attgcccgtc     5340

agcatttttg gccacctatt a                                               5361


<210> 32
<211> 5757
<212> DNA
<213> Mus musculus

<400> 32
gccccgtctt cacctggcta tcccttcatg gtgagcatag ccagaactca cctctaggcc       60

cagtgtgcac ctggaaatat ggctctgagc ctccagcccc agctgctcct tctcctgtcg      120

ctcctgccgc aggaagtgac ttcagcccct actgggcctc agtctttgga tgctggtctc      180

tcccttctga agtcattcgt agccactctg gaccaagctc ctcagcgttc cctcagccag      240

tcacggttct ctgcgttcct ggccaacatt tcttcatcct tccagcttgg gaggatgggg      300

gagggaccgg tgggagagcc cccacctctc cagccccctg cacttcgact tcatgatttc      360

ctcgtgacac tgagaggtag cccagactgg gagccaatgc tagggcttct gggagatgtg      420

ctggcactcc tgggacagga acagactccc cgggactttt tggtgcacca ggcaggtgta      480

ctgggtggac ttgtagaggc attgttggga gcgttagttc ctggaggccc ccctgccccc      540

actcgacccc catgcacccg tgatggccct tctgactgtg tcctggctgc tgattggttg      600

ccttctctga tgttgttatt agagggtaca cgctggcagg ccctggtgca gttgcagccc      660

agtgtggacc caaccaatgc cacaggtctt gatggtagag agccagctcc tcacttttta      720

cagggtctgc tgggcttgct taccccagca ggagagttgg gctctgagga ggctctttgg      780

ggtggtctgc tgcgcacagt gggggccccc ctctatgctg ccttccagga ggggctactg      840

cgagtcactc attctctgca agatgaggtc ttttctatta tgggacagcc agagcctgat      900

gccagtgggc agtgccaggg aggcaacctt caacagctgc ttttatgggg catgcggaac      960

aacctttctt gggacgcccg agcactgggt tttctatctg gatcaccacc tccaccccct     1020

gctctcctgc actgcctgag cagaggtgtg cctctgccca gggcttccca gcctgcggct     1080

cacatcagcc ctcgacagcg gcgagccatc tctgtggagg ccctctgcga gaaccactca     1140

ggcccagagc caccctacag catctccaac ttctccatct acttgctctg ccagcacatc     1200

aagcctgcca ccccgcggcc ccctcctacc accccacggc ctcctcctac caccccacag     1260

ccccctccta ccactacaca gcccattcct gacactacac agccccctcc tgtcacccca     1320

aggcctcctc ctaccacccc acaaccccct cctagcacag ctgtcatctg ccagacagct     1380

gtatggtacg cagtctcgtg ggcaccaggt gcccgaggtt ggctccaagc ctgccatgat     1440

cagtttcctg atcaatttct ggatatgatc tgcggcaacc tctcattttc agccctgtct     1500

ggccccagtc gtcctttggt aaagcagctc tgtgctggct tgctcccacc ccccactagc     1560

tgtccaccag gcctgatccc tgtgcccctc accccagaaa tattctgggg ctgtttcctg     1620

gagaatgaga cactgtgggc tgaacggttg tgtgtggagg acagtctgca ggctgtgccc     1680

ccgaggaacc aggcttgggt tcagcatgtg tgtcggggcc ccaccttgga cgccactgat     1740

tttccaccgt gccgcgttgg accctgtggg gaacgctgcc cagatggggg cagcttcctg     1800

ctcatggtct gtgccaatga cactctgtat gaagccttgg ttcccttctg ggcttggcta     1860

gcaggccaat gcagaattag tcgtggagga aatgatactt gctttctaga aggcatgctg     1920

ggccccttgt tgccctctct gccccctctg ggaccatccc cactctgtct ggctcctggt     1980

ccttttctgc ttggcatgtt atcccagttg ccacgctgtc agtcctccgt gccagccctc     2040

gcccacccca cgcgcctaca ttacctcctg cgcctactga ccttccttct gggtccaggg     2100

actgggggtg ccgagacgca ggggatgtta ggtcaagccc tgctgctctc tagtctccca     2160

gacaactgtt cattctggga tgccttccgc ccagagggcc ggagaagtgt actgaggaca     2220

gtcggagagt acttgcagcg ggaagagcca accccaccag gcttagactc ctccctcagc     2280

ctcggctctg gtatgagcaa gatggagctt ctgtcctgct tcagtcctgt actgtgggat     2340

ctactccaga gagagaagag cgtttgggcc ctgaggaccc tggtgaaggc ctacctgcgc     2400

atgcctccag aagaccttca gcagcttgtg ctttcagcag agatggaggc tgcacagggc     2460

ttcctgacgc tcatgcttcg ttcctgggct aagctgaagg ttcaaccatc cgaggagcag     2520

gccatgggcc gcctgacagc cttgctgctc cagcggtacc cacgcctcac ctcccaactc     2580

tttatcgaca tgtcaccgct catccccttc ctggctgtcc ctgacctcat gcgcttccca     2640

ccgtcccttt tggccaacga cagtgtcctg gctgccatca gggatcacag ctcaggaatg     2700

aagcctgaac agaaggaggc cctggcaaaa cgactgctgg cccctgagct gtttggagaa     2760

gtgcctgatt ggccccagga gctgctgtgg gcagccctgc ctctgcttcc ccatctgcct     2820

ctggagagct ttctccagct cagccctcac cagatccagg ccctggagga tagctggcca     2880

gtagcagatc ttgggccggg acacgcccga catgtgcttc gtagcctagt aaaccagagc     2940

atggaggatg gggaggagca ggtgctcagg cttgggtccc tcgcctgttt cctgagtcct     3000

gaggagctac agagtctggt gcccttgagt gatccaatgg ggcctgtaga acagggtctg     3060

ctggaatgtg cggccaatgg gaccctcagc ccagaaggac gggtggcata tgaacttctg     3120

ggagtgttgc gttcatctgg aggaactgtc ttaagccccc gagagctgag ggtctgggca     3180

cctctctttc cccagctggg cctccgcttc ctgcaggagc tctcagagac ccagcttaga     3240

gccatgcttc ctgccctaca gggagccagt gtcacacctg cccaggctgt tctgttgttt     3300

ggaaggctcc ttcctaagca tgatctgtcc ctggaggaac tctgctccct gcaccctctc     3360

ctgccaggtc tcagccccca gacactccag gccatcccta agagagttct ggttggtgct     3420

tgttcctgcc tgggccctga actgtcaagg ctttcagctt gccagattgc agctctgctg     3480

cagacctttc gggtaaaaga tggtgttaaa aatatgggtg cagcaggtgc cggctcagcc     3540

gtgtgcattc ctgggcagcc caccacttgg ccagactgcc tgcttcccct gctcccatta     3600

aagctgctac agctggacgc tgcagctctt ctggcaaacc gaagactcta tcggcagctg     3660

ccttggtctg agcaacaggc acagtttctc tggaagaaaa tgcaagtgcc taccaacctg     3720

agcctgagga atctgcaggc tctgggcaac ttggcaggag gcatgacctg cgagtttctg     3780

cagcagatca gctcaatggt tgactttctt gatgtggtac acatgctcta ccagctgccc     3840

actggtgttc gagagagcct gcgggcctgt atctggacag agctacagcg gaggatgaca     3900

atgccagagc cagagctgac caccctaggg ccagaactga gtgaacttga cacaaagcta     3960

ctcctggact tgccgatcca gctgatggac agattgtcca atgattccat tatgttggtg     4020

gtggagatgg tccaaggcgc tccagagcag ctgctggcac tgaccccact ccaccagaca     4080

gccttggcag agcgagcact taaaaacctg gctccaaagg agaccccaat ctccaaagaa     4140

gtgctggaga cactgggccc cttggttgga ttcctgggaa tagagagcac gcgacggatc     4200

cctttaccca ttctactgtc tcatctcagt cagctgcagg gcttctgcct aggagagaca     4260

tttgccacag agctgggatg gctgctgttg caggagcctg ttcttggaaa accagaattg     4320

tggagccagg atgaaataga gcaagctgga cgcctagtat tcactctgtc tgctgaggct     4380

atttcctcga tccccaggga ggctttgggc ccagagacac tggagaggct tctgggaaag     4440

catcaaagct gggagcagag cagagtgggc catctgtgtg gggagtcaca gcttgcccac     4500

aagaaagcag ctctggtagc tgggattgtg catccagctg ctgagggtct ccaagagcct     4560

gtaccaaact gtgcagacat acggggaacc ttcccagcgg cctggtctgc gacacaaatc     4620

tcagagatgg aactctcaga ctttgaagac tgcctgtcac tatttgctgg agatccagga     4680

cttggtcctg aggaactacg ggcagccatg ggcaaggcca agcagttgtg gggtccccct     4740

cgaggattcc gtcctgagca gatcttgcag ctgggccgtc tcctgatagg tctaggagaa     4800

cgggaactgc aggagcttac cttggtggac tggggtgtgc tgagcagcct ggggcaaata     4860

gatggctgga gttccatgca gctccgagcc gtggtctcca gtttcctaag gcagagtggt     4920

cggcatgtga gccacctgga cttcatttat ctgacagcac tgggttacac agtctgtgga     4980

ttgcgaccag aggagttaca gcacatcagc agttgggagt ttagccaagc agctctcttc     5040

ctgggtagct tgcatctccc gtgctctgag gaacagctgg aagttctggc ctatctcctt     5100

gtgttgcctg gtggctttgg cccagtcagt aactgggggc ctgagatctt cactgaaatt     5160

ggcacaatag cagctggcat cccagacctg gctctttcag cattactgcg gggacagatc     5220

caaggcctga ctcctcttgc catttctgtc attcctgctc ccaagtttgc agtggtcttc     5280

aaccccatcc agttatctag tctcaccagg ggtcaggccg tagctgttac tcctgaacag     5340

ctggcctatc tgagtcctga gcagcggcga gcagttgcat gggcccaaca cgaagggaag     5400

gagatcccag agcagctggg tcgaaactca gcctggggtc tctacgactg gttccaagcc     5460

tcctgggccc tggcattgcc cgtcagcatt tttggccacc tattatgata actgttcctt     5520

cagttgaggg agaaaattta catcatactg aacaacttgt aaatggaagt gcatactaat     5580

tattctcagt aagtggatga ggattgtggg taaaattcca atgcattcca cccacctgag     5640

aactgtgctc ctggcatata cgcctcttgc catcatgaat aacctcactg tttcttttca     5700

tttcctactt cctcctcacc acaccaatag aaataacaca gacagctgca acataat        5757


<210> 33
<211> 5379
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gcagtgactc tggcccctac tgggcctcat tccctggacc ctggtctctc cttcctgaag      120

tcattgctct ccactctgga ccaggctccc cagggctccc tgagccgctc acggttcttt      180

acattcctgg ccaacatttc ttcttccttt gagcctggga gaatggggga aggaccagta      240

ggagagcccc cacctctcca gccgcctgct ctgcggctcc atgattttct agtgacactg      300

agaggtagcc ccgactggga gccaatgcta gggctgctag gggatatgct ggcactgctg      360

ggacaggagc agactccccg agatttcctg gtgcaccagg caggggtgct gggtggactt      420

gtggaggtgc tgctgggagc cttagttcct gggggccccc ctaccccaac tcggccccca      480

tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg actggttgcc ttctctgctg      540

ctgttgttag agggcacacg ctggcaagct ctggtgcagg tgcagcccag tgtggacccc      600

accaatgcca caggcctcga tgggagggag gcagctcctc actttttgca gggtctgttg      660

ggtttgctta ccccaacagg ggagctaggc tccaaggagg ctctttgggg cggtctgcta      720

cgcacagtgg gggcccccct ctatgctgcc tttcaggagg ggctgctccg tgtcactcac      780

tccctgcagg atgaggtctt ctccattttg gggcagccag agcctgatac caatgggcag      840

tgccagggag gtaaccttca acagctgctc ttatggggcg tccggcacaa cctttcctgg      900

gatgtccagg cgctgggctt tctgtctgga tcaccacccc caccccctgc cctccttcac      960

tgcctgagca cgggcgtgcc tctgcccaga gcttctcagc cgtcagccca catcagccca     1020

cgccaacggc gagccatcac tgtggaggcc ctctgtgaga accacttagg cccagcacca     1080

ccctacagca tttccaactt ctccatccac ttgctctgcc agcacaccaa gcctgccact     1140

ccacagcccc atcccagcac cactgccatc tgccagacag ctgtgtggta tgcagtgtcc     1200

tgggcaccag gtgcccaagg ctggctacag gcctgccacg accagtttcc tgatgagttt     1260

ttggatgcga tctgcagtaa cctctccttt tcagccctgt ctggctccaa ccgccgcctg     1320

gtgaagcggc tctgtgctgg cctgctccca ccccctacca gctgccctga aggcctgccc     1380

cctgttcccc tcaccccaga catcttttgg ggctgcttct tggagaatga gactctgtgg     1440

gctgagcgac tgtgtgggga ggcaagtcta caggctgtgc cccccagcaa ccaggcttgg     1500

gtccagcatg tgtgccaggg ccccacccca gatgtcactg cctccccacc atgccacatt     1560

ggaccctgtg gggaacgctg cccggatggg ggcagcttcc tggtgatggt ctgtgccaat     1620

gacaccatgt atgaggtcct ggtgcccttc tggccttggc tagcaggcca atgcaggata     1680

agtcgtgggg gcaatgacac ttgcttccta gaagggctgc tgggccccct tctgccctct     1740

ctgccaccac tgggaccatc cccactctgt ctgacccctg gccccttcct ccttggcatg     1800

ctatcccagt tgccacgctg tcagtcctct gtcccagctc ttgctcaccc cacacgccta     1860

cactatctcc tccgcctgct gaccttcctc ttgggtccag gggctggggg cgctgaggcc     1920

caggggatgc tgggtcgggc cctactgctc tccagtctcc cagacaactg ctccttctgg     1980

gatgcctttc gcccagaggg ccggcgcagt gtgctacgga cgattgggga atacctggaa     2040

caagatgagg agcagccaac cccatcaggc tttgaaccca ctgtcaaccc cagctctggt     2100

ataagcaaga tggagctgct ggcctgcttt agtcctgtgc tgtgggatct gctccagagg     2160

gaaaagagtg tttgggccct gcagattcta gtgcaggcgt acctgcatat gcccccagaa     2220

aacctccagc agctggtgct ttcagcagag agggaggctg cacagggctt cctgacactc     2280

atgctgcagg ggaagctgca ggggaagctg caggtaccac catccgagga gcaggccctg     2340

ggtcgcctga cagccctgct gctccagcgg tacccacgcc tcacctccca gctcttcatt     2400

gacctgtcac cactcatccc tttcttggct gtctctgacc tgatgcgctt cccaccatcc     2460

ctgttagcca acgacagtgt cctggctgcc atccgggatt acagcccagg aatgaggcct     2520

gaacagaagg aggctctggc aaagcgactg ctggcccctg aactgtttgg ggaagtgcct     2580

gcctggcccc aggagctgct gtgggcagtg ctgcccctgc tcccccacct ccctctggag     2640

aactttttgc agctcagccc tcaccagatc caggccctgg aggatagctg gccagcagca     2700

ggtctggggc cagggcatgc ccgccatgtg ctgcgcagcc tggtaaacca gagtgtccag     2760

gatggtgagg agcaggtacg caggcttggg cccctcgcct gtttcctgag ccctgaggag     2820

ctgcagagcc tagtgcccct gagtgatcca acggggccag tagaacgggg gctgctggaa     2880

tgtgcagcca atgggaccct cagcccagaa ggacgggtgg catatgaact tctgggtgtg     2940

ttgcgctcat ctggaggagc ggtgctgagc ccccgggagc tgcgggtctg ggcccctctc     3000

ttctctcagc tgggcctccg cttccttcag gagctgtcag agccccagct tagagccatg     3060

cttcctgtcc tgcagggaac tagtgttaca cctgctcagg ctgtcctgct gcttggacgg     3120

ctccttccta ggcacgatct atccctggag gaactctgct ccttgcacct tctgctacca     3180

ggcctcagcc cccagacact ccaggccatc cctaggcgag tcctggtcgg ggcttgttcc     3240

tgcctggccc ctgaactgtc acgcctctca gcctgccaga ccgcagcact gctgcagacc     3300

tttcgggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtcc agctgtgtgt     3360

atccctggtc agcctattcc caccacctgg ccagactgcc tgcttcccct gctcccatta     3420

aagctgctac aactggattc cttggctctt ctggcaaatc gaagacgcta ctgggagctg     3480

ccctggtctg agcagcaggc acagtttctc tggaagaaga tgcaagtacc caccaacctt     3540

accctcagga atctgcaggc tctgggcacc ctggcaggag gcatgtcctg tgagtttctg     3600

cagcagatca actccatggt agacttcctt gaagtggtgc acatgatcta tcagctgccc     3660

actagagttc gagggagcct gagggcctgt atctgggcag agctacagcg gaggatggca     3720

atgccagaac cagaatggac aactgtaggg ccagaactga acgggctgga tagcaagcta     3780

ctcctggact taccgatcca gttgatggac agactatcca atgaatccat tatgttggtg     3840

gtggagctgg tgcaaagagc tccagagcag ctgctggcac tgacccccct ccaccaggca     3900

gccctggcag agagggcact acaaaacctg gctccaaagg agactccagt ctcaggggaa     3960

gtgctggaga ccttaggccc tttggttgga ttcctgggga cagagagcac acgacagatc     4020

cccctacaga tcctgctgtc ccatctcagt cagctgcaag gcttctgcct aggagagaca     4080

tttgccacag agctgggatg gctgctattg caggagtctg ttcttgggaa accagagttg     4140

tggagccagg atgaagtaga gcaagctgga cgcctagtat tcactctgtc tactgaggca     4200

atttccttga tccccaggga ggccttgggt ccagagaccc tggagcggct tctagaaaag     4260

cagcagagct gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgcc     4320

aagaaagcag ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccagaacct     4380

gtgccaaatt gtgcagatgt acgagggaca ttcccagcag cctggtctgc aacccagatt     4440

gcagagatgg agctctcaga ctttgaggac tgcctgacat tatttgcagg agacccagga     4500

cttgggcctg aggaactgcg ggcagccatg ggcaaagcaa aacagttgtg gggtcccccc     4560

cggggatttc gtcctgagca gatcctgcag cttggtaggc tcttaatagg tctaggagat     4620

cgggaactac aggagctgat cctagtggac tggggagtgc tgagcaccct ggggcagata     4680

gatggctgga gcaccactca gctccgcatt gtggtctcca gtttcctacg gcagagtggt     4740

cggcatgtga gccacctgga cttcgttcat ctgacagcgc tgggttatac tctctgtgga     4800

ctgcggccag aggagctcca gcacatcagc agttgggagt tcagccaagc agctctcttc     4860

ctcggcaccc tgcatctcca gtgctctgag gaacaactgg aggttctggc ccacctactt     4920

gtactgcctg gtgggtttgg cccaatcagt aactgggggc ctgagatctt cactgaaatt     4980

ggcaccatag cagctgggat cccagacctg gctctttcag cactgctgcg gggacagatc     5040

cagggcgtta ctcctcttgc catttctgtc atccctcctc ctaaatttgc tgtggtgttt     5100

agtcccatcc aactatctag tctcaccagt gctcaggctg tggctgtcac tcctgagcaa     5160

atggcctttc tgagtcctga gcagcgacga gcagttgcat gggcccaaca tgagggaaag     5220

gagagcccag aacagcaagg tcgaagtaca gcctggggcc tccaggactg gtcacgacct     5280

tcctggtccc tggtattgac tatcagcttc cttggccacc tgctaacgcg tacgcggccg     5340

ctcgagcaga aactcatctc agaagaggat ctgtaatag                            5379


<210> 34
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
acgcgtacgc ggccgctc                                                     18


<210> 35
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
gagcagaaac tcatctcaga agaggatctg                                        30


<210> 36
<211> 1791
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Phe Ala Val Thr Leu Ala Pro Thr Gly Pro His Ser Leu 
            20                  25                  30          


Asp Pro Gly Leu Ser Phe Leu Lys Ser Leu Leu Ser Thr Leu Asp Gln 
        35                  40                  45              


Ala Pro Gln Gly Ser Leu Ser Arg Ser Arg Phe Phe Thr Phe Leu Ala 
    50                  55                  60                  


Asn Ile Ser Ser Ser Phe Glu Pro Gly Arg Met Gly Glu Gly Pro Val 
65                  70                  75                  80  


Gly Glu Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe 
                85                  90                  95      


Leu Val Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu 
            100                 105                 110         


Leu Gly Asp Met Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp 
        115                 120                 125             


Phe Leu Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Val Leu 
    130                 135                 140                 


Leu Gly Ala Leu Val Pro Gly Gly Pro Pro Thr Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Cys Thr Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu 
                165                 170                 175     


Pro Ser Leu Leu Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val 
            180                 185                 190         


Gln Val Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly 
        195                 200                 205             


Arg Glu Ala Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Lys Glu Ala Leu Trp Gly Gly Leu Leu 
225                 230                 235                 240 


Arg Thr Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu 
                245                 250                 255     


Arg Val Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Leu Gly Gln 
            260                 265                 270         


Pro Glu Pro Asp Thr Asn Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln 
        275                 280                 285             


Leu Leu Leu Trp Gly Val Arg His Asn Leu Ser Trp Asp Val Gln Ala 
    290                 295                 300                 


Leu Gly Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His 
305                 310                 315                 320 


Cys Leu Ser Thr Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ser Ala 
                325                 330                 335     


His Ile Ser Pro Arg Gln Arg Arg Ala Ile Thr Val Glu Ala Leu Cys 
            340                 345                 350         


Glu Asn His Leu Gly Pro Ala Pro Pro Tyr Ser Ile Ser Asn Phe Ser 
        355                 360                 365             


Ile His Leu Leu Cys Gln His Thr Lys Pro Ala Thr Pro Gln Pro His 
    370                 375                 380                 


Pro Ser Thr Thr Ala Ile Cys Gln Thr Ala Val Trp Tyr Ala Val Ser 
385                 390                 395                 400 


Trp Ala Pro Gly Ala Gln Gly Trp Leu Gln Ala Cys His Asp Gln Phe 
                405                 410                 415     


Pro Asp Glu Phe Leu Asp Ala Ile Cys Ser Asn Leu Ser Phe Ser Ala 
            420                 425                 430         


Leu Ser Gly Ser Asn Arg Arg Leu Val Lys Arg Leu Cys Ala Gly Leu 
        435                 440                 445             


Leu Pro Pro Pro Thr Ser Cys Pro Glu Gly Leu Pro Pro Val Pro Leu 
    450                 455                 460                 


Thr Pro Asp Ile Phe Trp Gly Cys Phe Leu Glu Asn Glu Thr Leu Trp 
465                 470                 475                 480 


Ala Glu Arg Leu Cys Gly Glu Ala Ser Leu Gln Ala Val Pro Pro Ser 
                485                 490                 495     


Asn Gln Ala Trp Val Gln His Val Cys Gln Gly Pro Thr Pro Asp Val 
            500                 505                 510         


Thr Ala Ser Pro Pro Cys His Ile Gly Pro Cys Gly Glu Arg Cys Pro 
        515                 520                 525             


Asp Gly Gly Ser Phe Leu Val Met Val Cys Ala Asn Asp Thr Met Tyr 
    530                 535                 540                 


Glu Val Leu Val Pro Phe Trp Pro Trp Leu Ala Gly Gln Cys Arg Ile 
545                 550                 555                 560 


Ser Arg Gly Gly Asn Asp Thr Cys Phe Leu Glu Gly Leu Leu Gly Pro 
                565                 570                 575     


Leu Leu Pro Ser Leu Pro Pro Leu Gly Pro Ser Pro Leu Cys Leu Thr 
            580                 585                 590         


Pro Gly Pro Phe Leu Leu Gly Met Leu Ser Gln Leu Pro Arg Cys Gln 
        595                 600                 605             


Ser Ser Val Pro Ala Leu Ala His Pro Thr Arg Leu His Tyr Leu Leu 
    610                 615                 620                 


Arg Leu Leu Thr Phe Leu Leu Gly Pro Gly Ala Gly Gly Ala Glu Ala 
625                 630                 635                 640 


Gln Gly Met Leu Gly Arg Ala Leu Leu Leu Ser Ser Leu Pro Asp Asn 
                645                 650                 655     


Cys Ser Phe Trp Asp Ala Phe Arg Pro Glu Gly Arg Arg Ser Val Leu 
            660                 665                 670         


Arg Thr Ile Gly Glu Tyr Leu Glu Gln Asp Glu Glu Gln Pro Thr Pro 
        675                 680                 685             


Ser Gly Phe Glu Pro Thr Val Asn Pro Ser Ser Gly Ile Ser Lys Met 
    690                 695                 700                 


Glu Leu Leu Ala Cys Phe Ser Pro Val Leu Trp Asp Leu Leu Gln Arg 
705                 710                 715                 720 


Glu Lys Ser Val Trp Ala Leu Gln Ile Leu Val Gln Ala Tyr Leu His 
                725                 730                 735     


Met Pro Pro Glu Asn Leu Gln Gln Leu Val Leu Ser Ala Glu Arg Glu 
            740                 745                 750         


Ala Ala Gln Gly Phe Leu Thr Leu Met Leu Gln Gly Lys Leu Gln Gly 
        755                 760                 765             


Lys Leu Gln Val Pro Pro Ser Glu Glu Gln Ala Leu Gly Arg Leu Thr 
    770                 775                 780                 


Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser Gln Leu Phe Ile 
785                 790                 795                 800 


Asp Leu Ser Pro Leu Ile Pro Phe Leu Ala Val Ser Asp Leu Met Arg 
                805                 810                 815     


Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu Ala Ala Ile Arg 
            820                 825                 830         


Asp Tyr Ser Pro Gly Met Arg Pro Glu Gln Lys Glu Ala Leu Ala Lys 
        835                 840                 845             


Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro Ala Trp Pro Gln 
    850                 855                 860                 


Glu Leu Leu Trp Ala Val Leu Pro Leu Leu Pro His Leu Pro Leu Glu 
865                 870                 875                 880 


Asn Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala Leu Glu Asp Ser 
                885                 890                 895     


Trp Pro Ala Ala Gly Leu Gly Pro Gly His Ala Arg His Val Leu Arg 
            900                 905                 910         


Ser Leu Val Asn Gln Ser Val Gln Asp Gly Glu Glu Gln Val Arg Arg 
        915                 920                 925             


Leu Gly Pro Leu Ala Cys Phe Leu Ser Pro Glu Glu Leu Gln Ser Leu 
    930                 935                 940                 


Val Pro Leu Ser Asp Pro Thr Gly Pro Val Glu Arg Gly Leu Leu Glu 
945                 950                 955                 960 


Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg Val Ala Tyr Glu 
                965                 970                 975     


Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Ala Val Leu Ser Pro Arg 
            980                 985                 990         


Glu Leu Arg Val Trp Ala Pro Leu  Phe Ser Gln Leu Gly  Leu Arg Phe 
        995                 1000                 1005             


Leu Gln  Glu Leu Ser Glu Pro  Gln Leu Arg Ala Met  Leu Pro Val 
    1010                 1015                 1020             


Leu Gln  Gly Thr Ser Val Thr  Pro Ala Gln Ala Val  Leu Leu Leu 
    1025                 1030                 1035             


Gly Arg  Leu Leu Pro Arg His  Asp Leu Ser Leu Glu  Glu Leu Cys 
    1040                 1045                 1050             


Ser Leu  His Leu Leu Leu Pro  Gly Leu Ser Pro Gln  Thr Leu Gln 
    1055                 1060                 1065             


Ala Ile  Pro Arg Arg Val Leu  Val Gly Ala Cys Ser  Cys Leu Ala 
    1070                 1075                 1080             


Pro Glu  Leu Ser Arg Leu Ser  Ala Cys Gln Thr Ala  Ala Leu Leu 
    1085                 1090                 1095             


Gln Thr  Phe Arg Val Lys Asp  Gly Val Lys Asn Met  Gly Thr Thr 
    1100                 1105                 1110             


Gly Ala  Gly Pro Ala Val Cys  Ile Pro Gly Gln Pro  Ile Pro Thr 
    1115                 1120                 1125             


Thr Trp  Pro Asp Cys Leu Leu  Pro Leu Leu Pro Leu  Lys Leu Leu 
    1130                 1135                 1140             


Gln Leu  Asp Ser Leu Ala Leu  Leu Ala Asn Arg Arg  Arg Tyr Trp 
    1145                 1150                 1155             


Glu Leu  Pro Trp Ser Glu Gln  Gln Ala Gln Phe Leu  Trp Lys Lys 
    1160                 1165                 1170             


Met Gln  Val Pro Thr Asn Leu  Thr Leu Arg Asn Leu  Gln Ala Leu 
    1175                 1180                 1185             


Gly Thr  Leu Ala Gly Gly Met  Ser Cys Glu Phe Leu  Gln Gln Ile 
    1190                 1195                 1200             


Asn Ser  Met Val Asp Phe Leu  Glu Val Val His Met  Ile Tyr Gln 
    1205                 1210                 1215             


Leu Pro  Thr Arg Val Arg Gly  Ser Leu Arg Ala Cys  Ile Trp Ala 
    1220                 1225                 1230             


Glu Leu  Gln Arg Arg Met Ala  Met Pro Glu Pro Glu  Trp Thr Thr 
    1235                 1240                 1245             


Val Gly  Pro Glu Leu Asn Gly  Leu Asp Ser Lys Leu  Leu Leu Asp 
    1250                 1255                 1260             


Leu Pro  Ile Gln Leu Met Asp  Arg Leu Ser Asn Glu  Ser Ile Met 
    1265                 1270                 1275             


Leu Val  Val Glu Leu Val Gln  Arg Ala Pro Glu Gln  Leu Leu Ala 
    1280                 1285                 1290             


Leu Thr  Pro Leu His Gln Ala  Ala Leu Ala Glu Arg  Ala Leu Gln 
    1295                 1300                 1305             


Asn Leu  Ala Pro Lys Glu Thr  Pro Val Ser Gly Glu  Val Leu Glu 
    1310                 1315                 1320             


Thr Leu  Gly Pro Leu Val Gly  Phe Leu Gly Thr Glu  Ser Thr Arg 
    1325                 1330                 1335             


Gln Ile  Pro Leu Gln Ile Leu  Leu Ser His Leu Ser  Gln Leu Gln 
    1340                 1345                 1350             


Gly Phe  Cys Leu Gly Glu Thr  Phe Ala Thr Glu Leu  Gly Trp Leu 
    1355                 1360                 1365             


Leu Leu  Gln Glu Ser Val Leu  Gly Lys Pro Glu Leu  Trp Ser Gln 
    1370                 1375                 1380             


Asp Glu  Val Glu Gln Ala Gly  Arg Leu Val Phe Thr  Leu Ser Thr 
    1385                 1390                 1395             


Glu Ala  Ile Ser Leu Ile Pro  Arg Glu Ala Leu Gly  Pro Glu Thr 
    1400                 1405                 1410             


Leu Glu  Arg Leu Leu Glu Lys  Gln Gln Ser Trp Glu  Gln Ser Arg 
    1415                 1420                 1425             


Val Gly  Gln Leu Cys Arg Glu  Pro Gln Leu Ala Ala  Lys Lys Ala 
    1430                 1435                 1440             


Ala Leu  Val Ala Gly Val Val  Arg Pro Ala Ala Glu  Asp Leu Pro 
    1445                 1450                 1455             


Glu Pro  Val Pro Asn Cys Ala  Asp Val Arg Gly Thr  Phe Pro Ala 
    1460                 1465                 1470             


Ala Trp  Ser Ala Thr Gln Ile  Ala Glu Met Glu Leu  Ser Asp Phe 
    1475                 1480                 1485             


Glu Asp  Cys Leu Thr Leu Phe  Ala Gly Asp Pro Gly  Leu Gly Pro 
    1490                 1495                 1500             


Glu Glu  Leu Arg Ala Ala Met  Gly Lys Ala Lys Gln  Leu Trp Gly 
    1505                 1510                 1515             


Pro Pro  Arg Gly Phe Arg Pro  Glu Gln Ile Leu Gln  Leu Gly Arg 
    1520                 1525                 1530             


Leu Leu  Ile Gly Leu Gly Asp  Arg Glu Leu Gln Glu  Leu Ile Leu 
    1535                 1540                 1545             


Val Asp  Trp Gly Val Leu Ser  Thr Leu Gly Gln Ile  Asp Gly Trp 
    1550                 1555                 1560             


Ser Thr  Thr Gln Leu Arg Ile  Val Val Ser Ser Phe  Leu Arg Gln 
    1565                 1570                 1575             


Ser Gly  Arg His Val Ser His  Leu Asp Phe Val His  Leu Thr Ala 
    1580                 1585                 1590             


Leu Gly  Tyr Thr Leu Cys Gly  Leu Arg Pro Glu Glu  Leu Gln His 
    1595                 1600                 1605             


Ile Ser  Ser Trp Glu Phe Ser  Gln Ala Ala Leu Phe  Leu Gly Thr 
    1610                 1615                 1620             


Leu His  Leu Gln Cys Ser Glu  Glu Gln Leu Glu Val  Leu Ala His 
    1625                 1630                 1635             


Leu Leu  Val Leu Pro Gly Gly  Phe Gly Pro Ile Ser  Asn Trp Gly 
    1640                 1645                 1650             


Pro Glu  Ile Phe Thr Glu Ile  Gly Thr Ile Ala Ala  Gly Ile Pro 
    1655                 1660                 1665             


Asp Leu  Ala Leu Ser Ala Leu  Leu Arg Gly Gln Ile  Gln Gly Val 
    1670                 1675                 1680             


Thr Pro  Leu Ala Ile Ser Val  Ile Pro Pro Pro Lys  Phe Ala Val 
    1685                 1690                 1695             


Val Phe  Ser Pro Ile Gln Leu  Ser Ser Leu Thr Ser  Ala Gln Ala 
    1700                 1705                 1710             


Val Ala  Val Thr Pro Glu Gln  Met Ala Phe Leu Ser  Pro Glu Gln 
    1715                 1720                 1725             


Arg Arg  Ala Val Ala Trp Ala  Gln His Glu Gly Lys  Glu Ser Pro 
    1730                 1735                 1740             


Glu Gln  Gln Gly Arg Ser Thr  Ala Trp Gly Leu Gln  Asp Trp Ser 
    1745                 1750                 1755             


Arg Pro  Ser Trp Ser Leu Val  Leu Thr Ile Ser Phe  Leu Gly His 
    1760                 1765                 1770             


Leu Leu  Thr Arg Thr Arg Pro  Leu Glu Gln Lys Leu  Ile Ser Glu 
    1775                 1780                 1785             


Glu Asp  Leu 
    1790     


<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Thr Arg Thr Arg Pro Leu 
1               5       


<210> 38
<211> 5481
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc      120

gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc      180

ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag      240

cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt      300

agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag      360

gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag      420

gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc      480

cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta      540

ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat      600

gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg      660

cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca      720

gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg      780

caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag      840

ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc      900

cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg      960

agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag     1020

cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac     1080

agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg     1140

ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca     1200

cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc     1260

ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg     1320

tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt     1380

ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg     1440

gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc     1500

cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg     1560

gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg     1620

gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt     1680

ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat     1740

gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt     1800

agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct     1860

ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg     1920

ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta     1980

cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg     2040

caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg     2100

gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag     2160

cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc     2220

aagatggagc ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag     2280

agcgtttggg ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt     2340

cagcagcttg tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt     2400

cgttcctggg ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca     2460

gccttgctgc tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg     2520

ctcatcccct tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac     2580

gacagtgtcc tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag     2640

gccctggcaa aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag     2700

gagctgctgt gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag     2760

ctcagccctc accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg     2820

ggacacgccc gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag     2880

caggtgctca ggcttgggtc cctcgcctgt ttcctgagtc ctgaggagct acagagtctg     2940

gtgcccttga gtgatccaat ggggcctgta gaacagggtc tgctggaatg tgcggccaat     3000

gggaccctca gcccagaagg acgggtggca tatgaacttc tgggagtgtt gcgttcatct     3060

ggaggaactg tcttaagccc ccgagagctg agggtctggg cacctctctt tccccagctg     3120

ggcctccgct tcctgcagga gctctcagag acccagctta gagccatgct tcctgcccta     3180

cagggagcca gtgtcacacc tgcccaggct gttctgttgt ttggaaggct ccttcctaag     3240

catgatctgt ccctggagga actctgctcc ctgcaccctc tcctgccagg tctcagcccc     3300

cagacactcc aggccatccc taagagagtt ctggttggtg cttgttcctg cctgggccct     3360

gaactgtcaa ggctttcagc ttgccagatt gcagctctgc tgcagacctt tcgggtaaaa     3420

gatggtgtta aaaatatggg tgcagcaggt gccggctcag ccgtgtgcat tcctgggcag     3480

cccaccactt ggccagactg cctgcttccc ctgctcccat taaagctgct acagctggac     3540

gctgcagctc ttctggcaaa ccgaagactc tatcggcagc tgccttggtc tgagcaacag     3600

gcacagtttc tctggaagaa aatgcaagtg cctaccaacc tgagcctgag gaatctgcag     3660

gctctgggca acttggcagg aggcatgacc tgcgagtttc tgcagcagat cagctcaatg     3720

gttgactttc ttgatgtggt acacatgctc taccagctgc ccactggtgt tcgagagagc     3780

ctgcgggcct gtatctggac agagctacag cggaggatga caatgccaga gccagagctg     3840

accaccctag ggccagaact gagtgaactt gacacaaagc tactcctgga cttgccgatc     3900

cagctgatgg acagattgtc caatgattcc attatgttgg tggtggagat ggtccaaggc     3960

gctccagagc agctgctggc actgacccca ctccaccaga cagccttggc agagcgagca     4020

cttaaaaacc tggctccaaa ggagacccca atctccaaag aagtgctgga gacactgggc     4080

cccttggttg gattcctggg aatagagagc acgcgacgga tccctttacc cattctactg     4140

tctcatctca gtcagctgca gggcttctgc ctaggagaga catttgccac agagctggga     4200

tggctgctgt tgcaggagcc tgttcttgga aaaccagaat tgtggagcca ggatgaaata     4260

gagcaagctg gacgcctagt attcactctg tctgctgagg ctatttcctc gatccccagg     4320

gaggctttgg gcccagagac actggagagg cttctgggaa agcatcaaag ctgggagcag     4380

agcagagtgg gccatctgtg tggggagtca cagcttgccc acaagaaagc agctctggta     4440

gctgggattg tgcatccagc tgctgagggt ctccaagagc ctgtaccaaa ctgtgcagac     4500

atacggggaa ccttcccagc ggcctggtct gcgacacaaa tctcagagat ggaactctca     4560

gactttgaag actgcctgtc actatttgct ggagatccag gacttggtcc tgaggaacta     4620

cgggcagcca tgggcaaggc caagcagttg tggggtcccc ctcgaggatt ccgtcctgag     4680

cagatcttgc agctgggccg tctcctgata ggtctaggag aacgggaact gcaggagctt     4740

accttggtgg actggggtgt gctgagcagc ctggggcaaa tagatggctg gagttccatg     4800

cagctccgag ccgtggtctc cagtttccta aggcagagtg gtcggcatgt gagccacctg     4860

gacttcattt atctgacagc actgggttac acagtctgtg gattgcgacc agaggagtta     4920

cagcacatca gcagttggga gtttagccaa gcagctctct tcctgggtag cttgcatctc     4980

ccgtgctctg aggaacagct ggaagttctg gcctatctcc ttgtgttgcc tggtggcttt     5040

ggcccagtca gtaactgggg gcctgagatc ttcactgaaa ttggcacaat agcagctggc     5100

atcccagacc tggctctttc agcattactg cggggacaga tccaaggcct gactcctctt     5160

gccatttctg tcattcctgc tcccaagttt gcagtggtct tcaaccccat ccagttatct     5220

agtctcacca ggggtcaggc cgtagctgtt actcctgaac agctggccta tctgagtcct     5280

gagcagcggc gagcagttgc atgggcccaa cacgaaggga aggagatccc agagcagctg     5340

ggtcgaaact cagcctgggg tctctacgac tggttccaag cctcctgggc cctggcattg     5400

cccgtcagca tttttggcca cctattaacg cgtacgcggc cgctcgagca gaaactcatc     5460

tcagaagagg atctgtaata g                                               5481


<210> 39
<211> 1825
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 
            20                  25                  30          


Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 
        35                  40                  45              


Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 
    50                  55                  60                  


Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 
65                  70                  75                  80  


Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 
                85                  90                  95      


Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 
            100                 105                 110         


Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 
        115                 120                 125             


Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 
    130                 135                 140                 


Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 
145                 150                 155                 160 


Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 
                165                 170                 175     


Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 
            180                 185                 190         


Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 
        195                 200                 205             


Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 
    210                 215                 220                 


Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 
225                 230                 235                 240 


Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 
                245                 250                 255     


Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 
            260                 265                 270         


Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 
        275                 280                 285             


Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 
    290                 295                 300                 


Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 
305                 310                 315                 320 


Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 
                325                 330                 335     


Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 
            340                 345                 350         


His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 
        355                 360                 365             


Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 
    370                 375                 380                 


Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 
                405                 410                 415     


Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 
            420                 425                 430         


Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 
        435                 440                 445             


Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 
    450                 455                 460                 


Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 
465                 470                 475                 480 


Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 
                485                 490                 495     


Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 
            500                 505                 510         


Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 
        515                 520                 525             


Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 
    530                 535                 540                 


Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 
545                 550                 555                 560 


Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 
                565                 570                 575     


Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 
            580                 585                 590         


Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 
        595                 600                 605             


Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 
    610                 615                 620                 


Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 
625                 630                 635                 640 


Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 
                645                 650                 655     


Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 
            660                 665                 670         


Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 
        675                 680                 685             


Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 
    690                 695                 700                 


Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 
705                 710                 715                 720 


Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 
                725                 730                 735     


Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Phe Ser Pro Val Leu 
            740                 745                 750         


Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu 
        755                 760                 765             


Val Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val 
    770                 775                 780                 


Leu Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu 
785                 790                 795                 800 


Arg Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met 
                805                 810                 815     


Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 
            820                 825                 830         


Gln Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro 
        835                 840                 845             


Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 
    850                 855                 860                 


Ala Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu 
865                 870                 875                 880 


Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 
                885                 890                 895     


Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His 
            900                 905                 910         


Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 
        915                 920                 925             


Leu Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg 
    930                 935                 940                 


His Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu 
945                 950                 955                 960 


Gln Val Leu Arg Leu Gly Ser Leu Ala Cys Phe Leu Ser Pro Glu Glu 
                965                 970                 975     


Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln 
            980                 985                 990         


Gly Leu Leu Glu Cys Ala Ala Asn  Gly Thr Leu Ser Pro  Glu Gly Arg 
        995                 1000                 1005             


Val Ala  Tyr Glu Leu Leu Gly  Val Leu Arg Ser Ser  Gly Gly Thr 
    1010                 1015                 1020             


Val Leu  Ser Pro Arg Glu Leu  Arg Val Trp Ala Pro  Leu Phe Pro 
    1025                 1030                 1035             


Gln Leu  Gly Leu Arg Phe Leu  Gln Glu Leu Ser Glu  Thr Gln Leu 
    1040                 1045                 1050             


Arg Ala  Met Leu Pro Ala Leu  Gln Gly Ala Ser Val  Thr Pro Ala 
    1055                 1060                 1065             


Gln Ala  Val Leu Leu Phe Gly  Arg Leu Leu Pro Lys  His Asp Leu 
    1070                 1075                 1080             


Ser Leu  Glu Glu Leu Cys Ser  Leu His Pro Leu Leu  Pro Gly Leu 
    1085                 1090                 1095             


Ser Pro  Gln Thr Leu Gln Ala  Ile Pro Lys Arg Val  Leu Val Gly 
    1100                 1105                 1110             


Ala Cys  Ser Cys Leu Gly Pro  Glu Leu Ser Arg Leu  Ser Ala Cys 
    1115                 1120                 1125             


Gln Ile  Ala Ala Leu Leu Gln  Thr Phe Arg Val Lys  Asp Gly Val 
    1130                 1135                 1140             


Lys Asn  Met Gly Ala Ala Gly  Ala Gly Ser Ala Val  Cys Ile Pro 
    1145                 1150                 1155             


Gly Gln  Pro Thr Thr Trp Pro  Asp Cys Leu Leu Pro  Leu Leu Pro 
    1160                 1165                 1170             


Leu Lys  Leu Leu Gln Leu Asp  Ala Ala Ala Leu Leu  Ala Asn Arg 
    1175                 1180                 1185             


Arg Leu  Tyr Arg Gln Leu Pro  Trp Ser Glu Gln Gln  Ala Gln Phe 
    1190                 1195                 1200             


Leu Trp  Lys Lys Met Gln Val  Pro Thr Asn Leu Ser  Leu Arg Asn 
    1205                 1210                 1215             


Leu Gln  Ala Leu Gly Asn Leu  Ala Gly Gly Met Thr  Cys Glu Phe 
    1220                 1225                 1230             


Leu Gln  Gln Ile Ser Ser Met  Val Asp Phe Leu Asp  Val Val His 
    1235                 1240                 1245             


Met Leu  Tyr Gln Leu Pro Thr  Gly Val Arg Glu Ser  Leu Arg Ala 
    1250                 1255                 1260             


Cys Ile  Trp Thr Glu Leu Gln  Arg Arg Met Thr Met  Pro Glu Pro 
    1265                 1270                 1275             


Glu Leu  Thr Thr Leu Gly Pro  Glu Leu Ser Glu Leu  Asp Thr Lys 
    1280                 1285                 1290             


Leu Leu  Leu Asp Leu Pro Ile  Gln Leu Met Asp Arg  Leu Ser Asn 
    1295                 1300                 1305             


Asp Ser  Ile Met Leu Val Val  Glu Met Val Gln Gly  Ala Pro Glu 
    1310                 1315                 1320             


Gln Leu  Leu Ala Leu Thr Pro  Leu His Gln Thr Ala  Leu Ala Glu 
    1325                 1330                 1335             


Arg Ala  Leu Lys Asn Leu Ala  Pro Lys Glu Thr Pro  Ile Ser Lys 
    1340                 1345                 1350             


Glu Val  Leu Glu Thr Leu Gly  Pro Leu Val Gly Phe  Leu Gly Ile 
    1355                 1360                 1365             


Glu Ser  Thr Arg Arg Ile Pro  Leu Pro Ile Leu Leu  Ser His Leu 
    1370                 1375                 1380             


Ser Gln  Leu Gln Gly Phe Cys  Leu Gly Glu Thr Phe  Ala Thr Glu 
    1385                 1390                 1395             


Leu Gly  Trp Leu Leu Leu Gln  Glu Pro Val Leu Gly  Lys Pro Glu 
    1400                 1405                 1410             


Leu Trp  Ser Gln Asp Glu Ile  Glu Gln Ala Gly Arg  Leu Val Phe 
    1415                 1420                 1425             


Thr Leu  Ser Ala Glu Ala Ile  Ser Ser Ile Pro Arg  Glu Ala Leu 
    1430                 1435                 1440             


Gly Pro  Glu Thr Leu Glu Arg  Leu Leu Gly Lys His  Gln Ser Trp 
    1445                 1450                 1455             


Glu Gln  Ser Arg Val Gly His  Leu Cys Gly Glu Ser  Gln Leu Ala 
    1460                 1465                 1470             


His Lys  Lys Ala Ala Leu Val  Ala Gly Ile Val His  Pro Ala Ala 
    1475                 1480                 1485             


Glu Gly  Leu Gln Glu Pro Val  Pro Asn Cys Ala Asp  Ile Arg Gly 
    1490                 1495                 1500             


Thr Phe  Pro Ala Ala Trp Ser  Ala Thr Gln Ile Ser  Glu Met Glu 
    1505                 1510                 1515             


Leu Ser  Asp Phe Glu Asp Cys  Leu Ser Leu Phe Ala  Gly Asp Pro 
    1520                 1525                 1530             


Gly Leu  Gly Pro Glu Glu Leu  Arg Ala Ala Met Gly  Lys Ala Lys 
    1535                 1540                 1545             


Gln Leu  Trp Gly Pro Pro Arg  Gly Phe Arg Pro Glu  Gln Ile Leu 
    1550                 1555                 1560             


Gln Leu  Gly Arg Leu Leu Ile  Gly Leu Gly Glu Arg  Glu Leu Gln 
    1565                 1570                 1575             


Glu Leu  Thr Leu Val Asp Trp  Gly Val Leu Ser Ser  Leu Gly Gln 
    1580                 1585                 1590             


Ile Asp  Gly Trp Ser Ser Met  Gln Leu Arg Ala Val  Val Ser Ser 
    1595                 1600                 1605             


Phe Leu  Arg Gln Ser Gly Arg  His Val Ser His Leu  Asp Phe Ile 
    1610                 1615                 1620             


Tyr Leu  Thr Ala Leu Gly Tyr  Thr Val Cys Gly Leu  Arg Pro Glu 
    1625                 1630                 1635             


Glu Leu  Gln His Ile Ser Ser  Trp Glu Phe Ser Gln  Ala Ala Leu 
    1640                 1645                 1650             


Phe Leu  Gly Ser Leu His Leu  Pro Cys Ser Glu Glu  Gln Leu Glu 
    1655                 1660                 1665             


Val Leu  Ala Tyr Leu Leu Val  Leu Pro Gly Gly Phe  Gly Pro Val 
    1670                 1675                 1680             


Ser Asn  Trp Gly Pro Glu Ile  Phe Thr Glu Ile Gly  Thr Ile Ala 
    1685                 1690                 1695             


Ala Gly  Ile Pro Asp Leu Ala  Leu Ser Ala Leu Leu  Arg Gly Gln 
    1700                 1705                 1710             


Ile Gln  Gly Leu Thr Pro Leu  Ala Ile Ser Val Ile  Pro Ala Pro 
    1715                 1720                 1725             


Lys Phe  Ala Val Val Phe Asn  Pro Ile Gln Leu Ser  Ser Leu Thr 
    1730                 1735                 1740             


Arg Gly  Gln Ala Val Ala Val  Thr Pro Glu Gln Leu  Ala Tyr Leu 
    1745                 1750                 1755             


Ser Pro  Glu Gln Arg Arg Ala  Val Ala Trp Ala Gln  His Glu Gly 
    1760                 1765                 1770             


Lys Glu  Ile Pro Glu Gln Leu  Gly Arg Asn Ser Ala  Trp Gly Leu 
    1775                 1780                 1785             


Tyr Asp  Trp Phe Gln Ala Ser  Trp Ala Leu Ala Leu  Pro Val Ser 
    1790                 1795                 1800             


Ile Phe  Gly His Leu Leu Thr  Arg Thr Arg Pro Leu  Glu Gln Lys 
    1805                 1810                 1815             


Leu Ile  Ser Glu Glu Asp Leu  
    1820                 1825 


<210> 40
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
gctctcagcc tctggcccct gctgctgctg ctgctgctgc tgctgctgct gtcctttgca       60


<210> 41
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
gctctgagcc tccagcccca gctgctcctt ctcctgtcgc tcctgccgca ggaagtgact       60

tca                                                                     63


<210> 42
<211> 312
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
tgcctgtcat acgaaaccga gatactgaca gtagaatatg gccttctgcc aatcgggaag       60

attgtggaga aacggataga atgcacagtt tactctgtcg ataacaatgg taacatttat      120

actcagccag ttgcccagtg gcacgaccgg ggagagcagg aagtattcga atactgtctg      180

gaggatggaa gtctcattag ggccactaag gaccacaaat ttatgacagt cgatggccag      240

atgctgccta tagacgaaat ctttgagcga gagttggacc tcatgcgagt tgacaacctt      300

cctaattaat ag                                                          312


<210> 43
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Ala Leu Ser Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ser Phe Ala 
            20  


<210> 44
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu Pro 
1               5                   10                  15      


Gln Glu Val Thr Ser 
            20      


<210> 45
<211> 102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210> 46
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
atcaagatag ctacaaggaa gtatcttggc aaacaaaacg tttatgatat tggagtcgaa       60

agagatcaca actttgctct gaagaacgga ttcatagctt ctaat                      105


<210> 47
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
acgcgtacgc ggccgctc                                                     18


<210> 48
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
gagcagaaac tcatctcaga agaggatctg taatag                                 36


<210> 49
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 
            20                  25                  30          


Ala Ser Asn 
        35  


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Thr Arg Thr Arg Pro Leu 
1               5       


<210> 51
<211> 3219
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc      120

gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc      180

ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag      240

cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt      300

agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag      360

gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag      420

gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc      480

cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta      540

ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat      600

gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg      660

cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca      720

gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg      780

caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag      840

ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc      900

cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg      960

agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag     1020

cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac     1080

agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg     1140

ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca     1200

cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc     1260

ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg     1320

tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt     1380

ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg     1440

gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc     1500

cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg     1560

gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg     1620

gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt     1680

ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat     1740

gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt     1800

agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct     1860

ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg     1920

ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta     1980

cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg     2040

caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg     2100

gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag     2160

cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc     2220

aagatggagc ttctgtcctg cttcagtcct gtactgtggg atctactcca gagagagaag     2280

agcgtttggg ccctgaggac cctggtgaag gcctacctgc gcatgcctcc agaagacctt     2340

cagcagcttg tgctttcagc agagatggag gctgcacagg gcttcctgac gctcatgctt     2400

cgttcctggg ctaagctgaa ggttcaacca tccgaggagc aggccatggg ccgcctgaca     2460

gccttgctgc tccagcggta cccacgcctc acctcccaac tctttatcga catgtcaccg     2520

ctcatcccct tcctggctgt ccctgacctc atgcgcttcc caccgtccct tttggccaac     2580

gacagtgtcc tggctgccat cagggatcac agctcaggaa tgaagcctga acagaaggag     2640

gccctggcaa aacgactgct ggcccctgag ctgtttggag aagtgcctga ttggccccag     2700

gagctgctgt gggcagccct gcctctgctt ccccatctgc ctctggagag ctttctccag     2760

ctcagccctc accagatcca ggccctggag gatagctggc cagtagcaga tcttgggccg     2820

ggacacgccc gacatgtgct tcgtagccta gtaaaccaga gcatggagga tggggaggag     2880

caggtgctca ggcttgggtc cctcgcctgc ctgtcatacg aaaccgagat actgacagta     2940

gaatatggcc ttctgccaat cgggaagatt gtggagaaac ggatagaatg cacagtttac     3000

tctgtcgata acaatggtaa catttatact cagccagttg cccagtggca cgaccgggga     3060

gagcaggaag tattcgaata ctgtctggag gatggaagtc tcattagggc cactaaggac     3120

cacaaattta tgacagtcga tggccagatg ctgcctatag acgaaatctt tgagcgagag     3180

ttggacctca tgcgagttga caaccttcct aattaatag                            3219


<210> 52
<211> 1071
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ala Pro Thr Gly Pro Gln Ser Leu Asp Ala 
            20                  25                  30          


Gly Leu Ser Leu Leu Lys Ser Phe Val Ala Thr Leu Asp Gln Ala Pro 
        35                  40                  45              


Gln Arg Ser Leu Ser Gln Ser Arg Phe Ser Ala Phe Leu Ala Asn Ile 
    50                  55                  60                  


Ser Ser Ser Phe Gln Leu Gly Arg Met Gly Glu Gly Pro Val Gly Glu 
65                  70                  75                  80  


Pro Pro Pro Leu Gln Pro Pro Ala Leu Arg Leu His Asp Phe Leu Val 
                85                  90                  95      


Thr Leu Arg Gly Ser Pro Asp Trp Glu Pro Met Leu Gly Leu Leu Gly 
            100                 105                 110         


Asp Val Leu Ala Leu Leu Gly Gln Glu Gln Thr Pro Arg Asp Phe Leu 
        115                 120                 125             


Val His Gln Ala Gly Val Leu Gly Gly Leu Val Glu Ala Leu Leu Gly 
    130                 135                 140                 


Ala Leu Val Pro Gly Gly Pro Pro Ala Pro Thr Arg Pro Pro Cys Thr 
145                 150                 155                 160 


Arg Asp Gly Pro Ser Asp Cys Val Leu Ala Ala Asp Trp Leu Pro Ser 
                165                 170                 175     


Leu Met Leu Leu Leu Glu Gly Thr Arg Trp Gln Ala Leu Val Gln Leu 
            180                 185                 190         


Gln Pro Ser Val Asp Pro Thr Asn Ala Thr Gly Leu Asp Gly Arg Glu 
        195                 200                 205             


Pro Ala Pro His Phe Leu Gln Gly Leu Leu Gly Leu Leu Thr Pro Ala 
    210                 215                 220                 


Gly Glu Leu Gly Ser Glu Glu Ala Leu Trp Gly Gly Leu Leu Arg Thr 
225                 230                 235                 240 


Val Gly Ala Pro Leu Tyr Ala Ala Phe Gln Glu Gly Leu Leu Arg Val 
                245                 250                 255     


Thr His Ser Leu Gln Asp Glu Val Phe Ser Ile Met Gly Gln Pro Glu 
            260                 265                 270         


Pro Asp Ala Ser Gly Gln Cys Gln Gly Gly Asn Leu Gln Gln Leu Leu 
        275                 280                 285             


Leu Trp Gly Met Arg Asn Asn Leu Ser Trp Asp Ala Arg Ala Leu Gly 
    290                 295                 300                 


Phe Leu Ser Gly Ser Pro Pro Pro Pro Pro Ala Leu Leu His Cys Leu 
305                 310                 315                 320 


Ser Arg Gly Val Pro Leu Pro Arg Ala Ser Gln Pro Ala Ala His Ile 
                325                 330                 335     


Ser Pro Arg Gln Arg Arg Ala Ile Ser Val Glu Ala Leu Cys Glu Asn 
            340                 345                 350         


His Ser Gly Pro Glu Pro Pro Tyr Ser Ile Ser Asn Phe Ser Ile Tyr 
        355                 360                 365             


Leu Leu Cys Gln His Ile Lys Pro Ala Thr Pro Arg Pro Pro Pro Thr 
    370                 375                 380                 


Thr Pro Arg Pro Pro Pro Thr Thr Pro Gln Pro Pro Pro Thr Thr Thr 
385                 390                 395                 400 


Gln Pro Ile Pro Asp Thr Thr Gln Pro Pro Pro Val Thr Pro Arg Pro 
                405                 410                 415     


Pro Pro Thr Thr Pro Gln Pro Pro Pro Ser Thr Ala Val Ile Cys Gln 
            420                 425                 430         


Thr Ala Val Trp Tyr Ala Val Ser Trp Ala Pro Gly Ala Arg Gly Trp 
        435                 440                 445             


Leu Gln Ala Cys His Asp Gln Phe Pro Asp Gln Phe Leu Asp Met Ile 
    450                 455                 460                 


Cys Gly Asn Leu Ser Phe Ser Ala Leu Ser Gly Pro Ser Arg Pro Leu 
465                 470                 475                 480 


Val Lys Gln Leu Cys Ala Gly Leu Leu Pro Pro Pro Thr Ser Cys Pro 
                485                 490                 495     


Pro Gly Leu Ile Pro Val Pro Leu Thr Pro Glu Ile Phe Trp Gly Cys 
            500                 505                 510         


Phe Leu Glu Asn Glu Thr Leu Trp Ala Glu Arg Leu Cys Val Glu Asp 
        515                 520                 525             


Ser Leu Gln Ala Val Pro Pro Arg Asn Gln Ala Trp Val Gln His Val 
    530                 535                 540                 


Cys Arg Gly Pro Thr Leu Asp Ala Thr Asp Phe Pro Pro Cys Arg Val 
545                 550                 555                 560 


Gly Pro Cys Gly Glu Arg Cys Pro Asp Gly Gly Ser Phe Leu Leu Met 
                565                 570                 575     


Val Cys Ala Asn Asp Thr Leu Tyr Glu Ala Leu Val Pro Phe Trp Ala 
            580                 585                 590         


Trp Leu Ala Gly Gln Cys Arg Ile Ser Arg Gly Gly Asn Asp Thr Cys 
        595                 600                 605             


Phe Leu Glu Gly Met Leu Gly Pro Leu Leu Pro Ser Leu Pro Pro Leu 
    610                 615                 620                 


Gly Pro Ser Pro Leu Cys Leu Ala Pro Gly Pro Phe Leu Leu Gly Met 
625                 630                 635                 640 


Leu Ser Gln Leu Pro Arg Cys Gln Ser Ser Val Pro Ala Leu Ala His 
                645                 650                 655     


Pro Thr Arg Leu His Tyr Leu Leu Arg Leu Leu Thr Phe Leu Leu Gly 
            660                 665                 670         


Pro Gly Thr Gly Gly Ala Glu Thr Gln Gly Met Leu Gly Gln Ala Leu 
        675                 680                 685             


Leu Leu Ser Ser Leu Pro Asp Asn Cys Ser Phe Trp Asp Ala Phe Arg 
    690                 695                 700                 


Pro Glu Gly Arg Arg Ser Val Leu Arg Thr Val Gly Glu Tyr Leu Gln 
705                 710                 715                 720 


Arg Glu Glu Pro Thr Pro Pro Gly Leu Asp Ser Ser Leu Ser Leu Gly 
                725                 730                 735     


Ser Gly Met Ser Lys Met Glu Leu Leu Ser Cys Phe Ser Pro Val Leu 
            740                 745                 750         


Trp Asp Leu Leu Gln Arg Glu Lys Ser Val Trp Ala Leu Arg Thr Leu 
        755                 760                 765             


Val Lys Ala Tyr Leu Arg Met Pro Pro Glu Asp Leu Gln Gln Leu Val 
    770                 775                 780                 


Leu Ser Ala Glu Met Glu Ala Ala Gln Gly Phe Leu Thr Leu Met Leu 
785                 790                 795                 800 


Arg Ser Trp Ala Lys Leu Lys Val Gln Pro Ser Glu Glu Gln Ala Met 
                805                 810                 815     


Gly Arg Leu Thr Ala Leu Leu Leu Gln Arg Tyr Pro Arg Leu Thr Ser 
            820                 825                 830         


Gln Leu Phe Ile Asp Met Ser Pro Leu Ile Pro Phe Leu Ala Val Pro 
        835                 840                 845             


Asp Leu Met Arg Phe Pro Pro Ser Leu Leu Ala Asn Asp Ser Val Leu 
    850                 855                 860                 


Ala Ala Ile Arg Asp His Ser Ser Gly Met Lys Pro Glu Gln Lys Glu 
865                 870                 875                 880 


Ala Leu Ala Lys Arg Leu Leu Ala Pro Glu Leu Phe Gly Glu Val Pro 
                885                 890                 895     


Asp Trp Pro Gln Glu Leu Leu Trp Ala Ala Leu Pro Leu Leu Pro His 
            900                 905                 910         


Leu Pro Leu Glu Ser Phe Leu Gln Leu Ser Pro His Gln Ile Gln Ala 
        915                 920                 925             


Leu Glu Asp Ser Trp Pro Val Ala Asp Leu Gly Pro Gly His Ala Arg 
    930                 935                 940                 


His Val Leu Arg Ser Leu Val Asn Gln Ser Met Glu Asp Gly Glu Glu 
945                 950                 955                 960 


Gln Val Leu Arg Leu Gly Ser Leu Ala Cys Leu Ser Tyr Glu Thr Glu 
                965                 970                 975     


Ile Leu Thr Val Glu Tyr Gly Leu Leu Pro Ile Gly Lys Ile Val Glu 
            980                 985                 990         


Lys Arg Ile Glu Cys Thr Val Tyr  Ser Val Asp Asn Asn  Gly Asn Ile 
        995                 1000                 1005             


Tyr Thr  Gln Pro Val Ala Gln  Trp His Asp Arg Gly  Glu Gln Glu 
    1010                 1015                 1020             


Val Phe  Glu Tyr Cys Leu Glu  Asp Gly Ser Leu Ile  Arg Ala Thr 
    1025                 1030                 1035             


Lys Asp  His Lys Phe Met Thr  Val Asp Gly Gln Met  Leu Pro Ile 
    1040                 1045                 1050             


Asp Glu  Ile Phe Glu Arg Glu  Leu Asp Leu Met Arg  Val Asp Asn 
    1055                 1060                 1065             


Leu Pro  Asn 
    1070     


<210> 53
<211> 2745
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcaatca agatagctac aaggaagtat cttggcaaac aaaacgttta tgatattgga      120

gtcgaaagag atcacaactt tgctctgaag aacggattca tagcttctaa ttgtttcctg      180

agtcctgagg agctacagag tctggtgccc ttgagtgatc caatggggcc tgtagaacag      240

ggtctgctgg aatgtgcggc caatgggacc ctcagcccag aaggacgggt ggcatatgaa      300

cttctgggag tgttgcgttc atctggagga actgtcttaa gcccccgaga gctgagggtc      360

tgggcacctc tctttcccca gctgggcctc cgcttcctgc aggagctctc agagacccag      420

cttagagcca tgcttcctgc cctacaggga gccagtgtca cacctgccca ggctgttctg      480

ttgtttggaa ggctccttcc taagcatgat ctgtccctgg aggaactctg ctccctgcac      540

cctctcctgc caggtctcag cccccagaca ctccaggcca tccctaagag agttctggtt      600

ggtgcttgtt cctgcctggg ccctgaactg tcaaggcttt cagcttgcca gattgcagct      660

ctgctgcaga cctttcgggt aaaagatggt gttaaaaata tgggtgcagc aggtgccggc      720

tcagccgtgt gcattcctgg gcagcccacc acttggccag actgcctgct tcccctgctc      780

ccattaaagc tgctacagct ggacgctgca gctcttctgg caaaccgaag actctatcgg      840

cagctgcctt ggtctgagca acaggcacag tttctctgga agaaaatgca agtgcctacc      900

aacctgagcc tgaggaatct gcaggctctg ggcaacttgg caggaggcat gacctgcgag      960

tttctgcagc agatcagctc aatggttgac tttcttgatg tggtacacat gctctaccag     1020

ctgcccactg gtgttcgaga gagcctgcgg gcctgtatct ggacagagct acagcggagg     1080

atgacaatgc cagagccaga gctgaccacc ctagggccag aactgagtga acttgacaca     1140

aagctactcc tggacttgcc gatccagctg atggacagat tgtccaatga ttccattatg     1200

ttggtggtgg agatggtcca aggcgctcca gagcagctgc tggcactgac cccactccac     1260

cagacagcct tggcagagcg agcacttaaa aacctggctc caaaggagac cccaatctcc     1320

aaagaagtgc tggagacact gggccccttg gttggattcc tgggaataga gagcacgcga     1380

cggatccctt tacccattct actgtctcat ctcagtcagc tgcagggctt ctgcctagga     1440

gagacatttg ccacagagct gggatggctg ctgttgcagg agcctgttct tggaaaacca     1500

gaattgtgga gccaggatga aatagagcaa gctggacgcc tagtattcac tctgtctgct     1560

gaggctattt cctcgatccc cagggaggct ttgggcccag agacactgga gaggcttctg     1620

ggaaagcatc aaagctggga gcagagcaga gtgggccatc tgtgtgggga gtcacagctt     1680

gcccacaaga aagcagctct ggtagctggg attgtgcatc cagctgctga gggtctccaa     1740

gagcctgtac caaactgtgc agacatacgg ggaaccttcc cagcggcctg gtctgcgaca     1800

caaatctcag agatggaact ctcagacttt gaagactgcc tgtcactatt tgctggagat     1860

ccaggacttg gtcctgagga actacgggca gccatgggca aggccaagca gttgtggggt     1920

ccccctcgag gattccgtcc tgagcagatc ttgcagctgg gccgtctcct gataggtcta     1980

ggagaacggg aactgcagga gcttaccttg gtggactggg gtgtgctgag cagcctgggg     2040

caaatagatg gctggagttc catgcagctc cgagccgtgg tctccagttt cctaaggcag     2100

agtggtcggc atgtgagcca cctggacttc atttatctga cagcactggg ttacacagtc     2160

tgtggattgc gaccagagga gttacagcac atcagcagtt gggagtttag ccaagcagct     2220

ctcttcctgg gtagcttgca tctcccgtgc tctgaggaac agctggaagt tctggcctat     2280

ctccttgtgt tgcctggtgg ctttggccca gtcagtaact gggggcctga gatcttcact     2340

gaaattggca caatagcagc tggcatccca gacctggctc tttcagcatt actgcgggga     2400

cagatccaag gcctgactcc tcttgccatt tctgtcattc ctgctcccaa gtttgcagtg     2460

gtcttcaacc ccatccagtt atctagtctc accaggggtc aggccgtagc tgttactcct     2520

gaacagctgg cctatctgag tcctgagcag cggcgagcag ttgcatgggc ccaacacgaa     2580

gggaaggaga tcccagagca gctgggtcga aactcagcct ggggtctcta cgactggttc     2640

caagcctcct gggccctggc attgcccgtc agcatttttg gccacctatt aacgcgtacg     2700

cggccgctcg agcagaaact catctcagaa gaggatctgt aatag                     2745


<210> 54
<211> 913
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Met Ala Leu Ser Leu Gln Pro Gln Leu Leu Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Pro Gln Glu Val Thr Ser Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly 
            20                  25                  30          


Lys Gln Asn Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala 
        35                  40                  45              


Leu Lys Asn Gly Phe Ile Ala Ser Asn Cys Phe Leu Ser Pro Glu Glu 
    50                  55                  60                  


Leu Gln Ser Leu Val Pro Leu Ser Asp Pro Met Gly Pro Val Glu Gln 
65                  70                  75                  80  


Gly Leu Leu Glu Cys Ala Ala Asn Gly Thr Leu Ser Pro Glu Gly Arg 
                85                  90                  95      


Val Ala Tyr Glu Leu Leu Gly Val Leu Arg Ser Ser Gly Gly Thr Val 
            100                 105                 110         


Leu Ser Pro Arg Glu Leu Arg Val Trp Ala Pro Leu Phe Pro Gln Leu 
        115                 120                 125             


Gly Leu Arg Phe Leu Gln Glu Leu Ser Glu Thr Gln Leu Arg Ala Met 
    130                 135                 140                 


Leu Pro Ala Leu Gln Gly Ala Ser Val Thr Pro Ala Gln Ala Val Leu 
145                 150                 155                 160 


Leu Phe Gly Arg Leu Leu Pro Lys His Asp Leu Ser Leu Glu Glu Leu 
                165                 170                 175     


Cys Ser Leu His Pro Leu Leu Pro Gly Leu Ser Pro Gln Thr Leu Gln 
            180                 185                 190         


Ala Ile Pro Lys Arg Val Leu Val Gly Ala Cys Ser Cys Leu Gly Pro 
        195                 200                 205             


Glu Leu Ser Arg Leu Ser Ala Cys Gln Ile Ala Ala Leu Leu Gln Thr 
    210                 215                 220                 


Phe Arg Val Lys Asp Gly Val Lys Asn Met Gly Ala Ala Gly Ala Gly 
225                 230                 235                 240 


Ser Ala Val Cys Ile Pro Gly Gln Pro Thr Thr Trp Pro Asp Cys Leu 
                245                 250                 255     


Leu Pro Leu Leu Pro Leu Lys Leu Leu Gln Leu Asp Ala Ala Ala Leu 
            260                 265                 270         


Leu Ala Asn Arg Arg Leu Tyr Arg Gln Leu Pro Trp Ser Glu Gln Gln 
        275                 280                 285             


Ala Gln Phe Leu Trp Lys Lys Met Gln Val Pro Thr Asn Leu Ser Leu 
    290                 295                 300                 


Arg Asn Leu Gln Ala Leu Gly Asn Leu Ala Gly Gly Met Thr Cys Glu 
305                 310                 315                 320 


Phe Leu Gln Gln Ile Ser Ser Met Val Asp Phe Leu Asp Val Val His 
                325                 330                 335     


Met Leu Tyr Gln Leu Pro Thr Gly Val Arg Glu Ser Leu Arg Ala Cys 
            340                 345                 350         


Ile Trp Thr Glu Leu Gln Arg Arg Met Thr Met Pro Glu Pro Glu Leu 
        355                 360                 365             


Thr Thr Leu Gly Pro Glu Leu Ser Glu Leu Asp Thr Lys Leu Leu Leu 
    370                 375                 380                 


Asp Leu Pro Ile Gln Leu Met Asp Arg Leu Ser Asn Asp Ser Ile Met 
385                 390                 395                 400 


Leu Val Val Glu Met Val Gln Gly Ala Pro Glu Gln Leu Leu Ala Leu 
                405                 410                 415     


Thr Pro Leu His Gln Thr Ala Leu Ala Glu Arg Ala Leu Lys Asn Leu 
            420                 425                 430         


Ala Pro Lys Glu Thr Pro Ile Ser Lys Glu Val Leu Glu Thr Leu Gly 
        435                 440                 445             


Pro Leu Val Gly Phe Leu Gly Ile Glu Ser Thr Arg Arg Ile Pro Leu 
    450                 455                 460                 


Pro Ile Leu Leu Ser His Leu Ser Gln Leu Gln Gly Phe Cys Leu Gly 
465                 470                 475                 480 


Glu Thr Phe Ala Thr Glu Leu Gly Trp Leu Leu Leu Gln Glu Pro Val 
                485                 490                 495     


Leu Gly Lys Pro Glu Leu Trp Ser Gln Asp Glu Ile Glu Gln Ala Gly 
            500                 505                 510         


Arg Leu Val Phe Thr Leu Ser Ala Glu Ala Ile Ser Ser Ile Pro Arg 
        515                 520                 525             


Glu Ala Leu Gly Pro Glu Thr Leu Glu Arg Leu Leu Gly Lys His Gln 
    530                 535                 540                 


Ser Trp Glu Gln Ser Arg Val Gly His Leu Cys Gly Glu Ser Gln Leu 
545                 550                 555                 560 


Ala His Lys Lys Ala Ala Leu Val Ala Gly Ile Val His Pro Ala Ala 
                565                 570                 575     


Glu Gly Leu Gln Glu Pro Val Pro Asn Cys Ala Asp Ile Arg Gly Thr 
            580                 585                 590         


Phe Pro Ala Ala Trp Ser Ala Thr Gln Ile Ser Glu Met Glu Leu Ser 
        595                 600                 605             


Asp Phe Glu Asp Cys Leu Ser Leu Phe Ala Gly Asp Pro Gly Leu Gly 
    610                 615                 620                 


Pro Glu Glu Leu Arg Ala Ala Met Gly Lys Ala Lys Gln Leu Trp Gly 
625                 630                 635                 640 


Pro Pro Arg Gly Phe Arg Pro Glu Gln Ile Leu Gln Leu Gly Arg Leu 
                645                 650                 655     


Leu Ile Gly Leu Gly Glu Arg Glu Leu Gln Glu Leu Thr Leu Val Asp 
            660                 665                 670         


Trp Gly Val Leu Ser Ser Leu Gly Gln Ile Asp Gly Trp Ser Ser Met 
        675                 680                 685             


Gln Leu Arg Ala Val Val Ser Ser Phe Leu Arg Gln Ser Gly Arg His 
    690                 695                 700                 


Val Ser His Leu Asp Phe Ile Tyr Leu Thr Ala Leu Gly Tyr Thr Val 
705                 710                 715                 720 


Cys Gly Leu Arg Pro Glu Glu Leu Gln His Ile Ser Ser Trp Glu Phe 
                725                 730                 735     


Ser Gln Ala Ala Leu Phe Leu Gly Ser Leu His Leu Pro Cys Ser Glu 
            740                 745                 750         


Glu Gln Leu Glu Val Leu Ala Tyr Leu Leu Val Leu Pro Gly Gly Phe 
        755                 760                 765             


Gly Pro Val Ser Asn Trp Gly Pro Glu Ile Phe Thr Glu Ile Gly Thr 
    770                 775                 780                 


Ile Ala Ala Gly Ile Pro Asp Leu Ala Leu Ser Ala Leu Leu Arg Gly 
785                 790                 795                 800 


Gln Ile Gln Gly Leu Thr Pro Leu Ala Ile Ser Val Ile Pro Ala Pro 
                805                 810                 815     


Lys Phe Ala Val Val Phe Asn Pro Ile Gln Leu Ser Ser Leu Thr Arg 
            820                 825                 830         


Gly Gln Ala Val Ala Val Thr Pro Glu Gln Leu Ala Tyr Leu Ser Pro 
        835                 840                 845             


Glu Gln Arg Arg Ala Val Ala Trp Ala Gln His Glu Gly Lys Glu Ile 
    850                 855                 860                 


Pro Glu Gln Leu Gly Arg Asn Ser Ala Trp Gly Leu Tyr Asp Trp Phe 
865                 870                 875                 880 


Gln Ala Ser Trp Ala Leu Ala Leu Pro Val Ser Ile Phe Gly His Leu 
                885                 890                 895     


Leu Thr Arg Thr Arg Pro Leu Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            900                 905                 910         


Leu 
    


<210> 55
<211> 2124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 55
atggctctca gcctctggcc cctgctgctg ctgctgctgc tgctgctgct gctgtccttt       60

gcagtgactc tggcccctac tgggcctcat tccctggacc ctggtctctc cttcctgaag      120

tcattgctct ccactctgga ccaggctccc cagggctccc tgagccgctc acggttcttt      180

acattcctgg ccaacatttc ttcttccttt gagcctggga gaatggggga aggaccagta      240

ggagagcccc cacctctcca gccgcctgct ctgcggctcc atgattttct agtgacactg      300

agaggtagcc ccgactggga gccaatgcta gggctgctag gggatatgct ggcactgctg      360

ggacaggagc agactccccg agatttcctg gtgcaccagg caggggtgct gggtggactt      420

gtggaggtgc tgctgggagc cttagttcct gggggccccc ctaccccaac tcggccccca      480

tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg actggttgcc ttctctgctg      540

ctgttgttag agggcacacg ctggcaagct ctggtgcagg tgcagcccag tgtggacccc      600

accaatgcca caggcctcga tgggagggag gcagctcctc actttttgca gggtctgttg      660

ggtttgctta ccccaacagg ggagctaggc tccaaggagg ctctttgggg cggtctgcta      720

cgcacagtgg gggcccccct ctatgctgcc tttcaggagg ggctgctccg tgtcactcac      780

tccctgcagg atgaggtctt ctccattttg gggcagccag agcctgatac caatgggcag      840

tgccagggag gtaaccttca acagctgctc ttatggggcg tccggcacaa cctttcctgg      900

gatgtccagg cgctgggctt tctgtctgga tcaccacccc caccccctgc cctccttcac      960

tgcctgagca cgggcgtgcc tctgcccaga gcttctcagc cgtcagccca catcagccca     1020

cgccaacggc gagccatcac tgtggaggcc ctctgtgaga accacttagg cccagcacca     1080

ccctacagca tttccaactt ctccatccac ttgctctgcc agcacaccaa gcctgccact     1140

ccacagcccc atcccagcac cactgccatc tgccagacag ctgtgtggta tgcagtgtcc     1200

tgggcaccag gtgcccaagg ctggctacag gcctgccacg accagtttcc tgatgagttt     1260

ttggatgcga tctgcagtaa cctctccttt tcagccctgt ctggctccaa ccgccgcctg     1320

gtgaagcggc tctgtgctgg cctgctccca ccccctacca gctgccctga aggcctgccc     1380

cctgttcccc tcaccccaga catcttttgg ggctgcttct tggagaatga gactctgtgg     1440

gctgagcgac tgtgtgggga ggcaagtcta caggctgtgc cccccagcaa ccaggcttgg     1500

gtccagcatg tgtgccaggg ccccacccca gatgtcactg cctccccacc atgccacatt     1560

ggaccctgtg gggaacgctg cccggatggg ggcagcttcc tggtgatggt ctgtgccaat     1620

gacaccatgt atgaggtcct ggtgcccttc tggccttggc tagcaggcca atgcaggata     1680

agtcgtgggg gcaatgacac ttgcttccta gaagggctgc tgggccccct tctgccctct     1740

ctgccaccac tgggaccatc cccactctgt ctgacccctg gccccttcct ccttggcatg     1800

ctatcccagt tgccacgctg tcagtcctct gtcccagctc ttgctcaccc cacacgccta     1860

cactatctcc tccgcctgct gaccttcctc ttgggtccag gggctggggg cgctgaggcc     1920

caggggatgc tgggtcgggc cctactgctc tccagtctcc cagacaactg ctccttctgg     1980

gatgcctttc gcccagaggg ccggcgcagt gtgctacgga cgattgggga atacctggaa     2040

caagatgagg agcagccaac cccatcaggc tttgaaccca ctgtcaaccc cagctctggt     2100

ataagcaaga tggagctgct ggcc                                            2124


<210> 56
<211> 2238
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 56
atggctctga gcctccagcc ccagctgctc cttctcctgt cgctcctgcc gcaggaagtg       60

acttcagccc ctactgggcc tcagtctttg gatgctggtc tctcccttct gaagtcattc      120

gtagccactc tggaccaagc tcctcagcgt tccctcagcc agtcacggtt ctctgcgttc      180

ctggccaaca tttcttcatc cttccagctt gggaggatgg gggagggacc ggtgggagag      240

cccccacctc tccagccccc tgcacttcga cttcatgatt tcctcgtgac actgagaggt      300

agcccagact gggagccaat gctagggctt ctgggagatg tgctggcact cctgggacag      360

gaacagactc cccgggactt tttggtgcac caggcaggtg tactgggtgg acttgtagag      420

gcattgttgg gagcgttagt tcctggaggc ccccctgccc ccactcgacc cccatgcacc      480

cgtgatggcc cttctgactg tgtcctggct gctgattggt tgccttctct gatgttgtta      540

ttagagggta cacgctggca ggccctggtg cagttgcagc ccagtgtgga cccaaccaat      600

gccacaggtc ttgatggtag agagccagct cctcactttt tacagggtct gctgggcttg      660

cttaccccag caggagagtt gggctctgag gaggctcttt ggggtggtct gctgcgcaca      720

gtgggggccc ccctctatgc tgccttccag gaggggctac tgcgagtcac tcattctctg      780

caagatgagg tcttttctat tatgggacag ccagagcctg atgccagtgg gcagtgccag      840

ggaggcaacc ttcaacagct gcttttatgg ggcatgcgga acaacctttc ttgggacgcc      900

cgagcactgg gttttctatc tggatcacca cctccacccc ctgctctcct gcactgcctg      960

agcagaggtg tgcctctgcc cagggcttcc cagcctgcgg ctcacatcag ccctcgacag     1020

cggcgagcca tctctgtgga ggccctctgc gagaaccact caggcccaga gccaccctac     1080

agcatctcca acttctccat ctacttgctc tgccagcaca tcaagcctgc caccccgcgg     1140

ccccctccta ccaccccacg gcctcctcct accaccccac agccccctcc taccactaca     1200

cagcccattc ctgacactac acagccccct cctgtcaccc caaggcctcc tcctaccacc     1260

ccacaacccc ctcctagcac agctgtcatc tgccagacag ctgtatggta cgcagtctcg     1320

tgggcaccag gtgcccgagg ttggctccaa gcctgccatg atcagtttcc tgatcaattt     1380

ctggatatga tctgcggcaa cctctcattt tcagccctgt ctggccccag tcgtcctttg     1440

gtaaagcagc tctgtgctgg cttgctccca ccccccacta gctgtccacc aggcctgatc     1500

cctgtgcccc tcaccccaga aatattctgg ggctgtttcc tggagaatga gacactgtgg     1560

gctgaacggt tgtgtgtgga ggacagtctg caggctgtgc ccccgaggaa ccaggcttgg     1620

gttcagcatg tgtgtcgggg ccccaccttg gacgccactg attttccacc gtgccgcgtt     1680

ggaccctgtg gggaacgctg cccagatggg ggcagcttcc tgctcatggt ctgtgccaat     1740

gacactctgt atgaagcctt ggttcccttc tgggcttggc tagcaggcca atgcagaatt     1800

agtcgtggag gaaatgatac ttgctttcta gaaggcatgc tgggcccctt gttgccctct     1860

ctgccccctc tgggaccatc cccactctgt ctggctcctg gtccttttct gcttggcatg     1920

ttatcccagt tgccacgctg tcagtcctcc gtgccagccc tcgcccaccc cacgcgccta     1980

cattacctcc tgcgcctact gaccttcctt ctgggtccag ggactggggg tgccgagacg     2040

caggggatgt taggtcaagc cctgctgctc tctagtctcc cagacaactg ttcattctgg     2100

gatgccttcc gcccagaggg ccggagaagt gtactgagga cagtcggaga gtacttgcag     2160

cgggaagagc caaccccacc aggcttagac tcctccctca gcctcggctc tggtatgagc     2220

aagatggagc ttctgtcc                                                   2238


<210> 57
<211> 3201
<212> DNA
<213> Homo sapiens

<400> 57
tgctttagtc ctgtgctgtg ggatctgctc cagagggaaa agagtgtttg ggccctgcag       60

attctagtgc aggcgtacct gcatatgccc ccagaaaacc tccagcagct ggtgctttca      120

gcagagaggg aggctgcaca gggcttcctg acactcatgc tgcaggggaa gctgcagggg      180

aagctgcagg taccaccatc cgaggagcag gccctgggtc gcctgacagc cctgctgctc      240

cagcggtacc cacgcctcac ctcccagctc ttcattgacc tgtcaccact catccctttc      300

ttggctgtct ctgacctgat gcgcttccca ccatccctgt tagccaacga cagtgtcctg      360

gctgccatcc gggattacag cccaggaatg aggcctgaac agaaggaggc tctggcaaag      420

cgactgctgg cccctgaact gtttggggaa gtgcctgcct ggccccagga gctgctgtgg      480

gcagtgctgc ccctgctccc ccacctccct ctggagaact ttttgcagct cagccctcac      540

cagatccagg ccctggagga tagctggcca gcagcaggtc tggggccagg gcatgcccgc      600

catgtgctgc gcagcctggt aaaccagagt gtccaggatg gtgaggagca ggtacgcagg      660

cttgggcccc tcgcctgttt cctgagccct gaggagctgc agagcctagt gcccctgagt      720

gatccaacgg ggccagtaga acgggggctg ctggaatgtg cagccaatgg gaccctcagc      780

ccagaaggac gggtggcata tgaacttctg ggtgtgttgc gctcatctgg aggagcggtg      840

ctgagccccc gggagctgcg ggtctgggcc cctctcttct ctcagctggg cctccgcttc      900

cttcaggagc tgtcagagcc ccagcttaga gccatgcttc ctgtcctgca gggaactagt      960

gttacacctg ctcaggctgt cctgctgctt ggacggctcc ttcctaggca cgatctatcc     1020

ctggaggaac tctgctcctt gcaccttctg ctaccaggcc tcagccccca gacactccag     1080

gccatcccta ggcgagtcct ggtcggggct tgttcctgcc tggcccctga actgtcacgc     1140

ctctcagcct gccagaccgc agcactgctg cagacctttc gggttaaaga tggtgttaaa     1200

aatatgggta caacaggtgc tggtccagct gtgtgtatcc ctggtcagcc tattcccacc     1260

acctggccag actgcctgct tcccctgctc ccattaaagc tgctacaact ggattccttg     1320

gctcttctgg caaatcgaag acgctactgg gagctgccct ggtctgagca gcaggcacag     1380

tttctctgga agaagatgca agtacccacc aaccttaccc tcaggaatct gcaggctctg     1440

ggcaccctgg caggaggcat gtcctgtgag tttctgcagc agatcaactc catggtagac     1500

ttccttgaag tggtgcacat gatctatcag ctgcccacta gagttcgagg gagcctgagg     1560

gcctgtatct gggcagagct acagcggagg atggcaatgc cagaaccaga atggacaact     1620

gtagggccag aactgaacgg gctggatagc aagctactcc tggacttacc gatccagttg     1680

atggacagac tatccaatga atccattatg ttggtggtgg agctggtgca aagagctcca     1740

gagcagctgc tggcactgac ccccctccac caggcagccc tggcagagag ggcactacaa     1800

aacctggctc caaaggagac tccagtctca ggggaagtgc tggagacctt aggccctttg     1860

gttggattcc tggggacaga gagcacacga cagatccccc tacagatcct gctgtcccat     1920

ctcagtcagc tgcaaggctt ctgcctagga gagacatttg ccacagagct gggatggctg     1980

ctattgcagg agtctgttct tgggaaacca gagttgtgga gccaggatga agtagagcaa     2040

gctggacgcc tagtattcac tctgtctact gaggcaattt ccttgatccc cagggaggcc     2100

ttgggtccag agaccctgga gcggcttcta gaaaagcagc agagctggga gcagagcaga     2160

gttggacagc tgtgtaggga gccacagctt gctgccaaga aagcagccct ggtagcaggg     2220

gtggtgcgac cagctgctga ggatcttcca gaacctgtgc caaattgtgc agatgtacga     2280

gggacattcc cagcagcctg gtctgcaacc cagattgcag agatggagct ctcagacttt     2340

gaggactgcc tgacattatt tgcaggagac ccaggacttg ggcctgagga actgcgggca     2400

gccatgggca aagcaaaaca gttgtggggt cccccccggg gatttcgtcc tgagcagatc     2460

ctgcagcttg gtaggctctt aataggtcta ggagatcggg aactacagga gctgatccta     2520

gtggactggg gagtgctgag caccctgggg cagatagatg gctggagcac cactcagctc     2580

cgcattgtgg tctccagttt cctacggcag agtggtcggc atgtgagcca cctggacttc     2640

gttcatctga cagcgctggg ttatactctc tgtggactgc ggccagagga gctccagcac     2700

atcagcagtt gggagttcag ccaagcagct ctcttcctcg gcaccctgca tctccagtgc     2760

tctgaggaac aactggaggt tctggcccac ctacttgtac tgcctggtgg gtttggccca     2820

atcagtaact gggggcctga gatcttcact gaaattggca ccatagcagc tgggatccca     2880

gacctggctc tttcagcact gctgcgggga cagatccagg gcgttactcc tcttgccatt     2940

tctgtcatcc ctcctcctaa atttgctgtg gtgtttagtc ccatccaact atctagtctc     3000

accagtgctc aggctgtggc tgtcactcct gagcaaatgg cctttctgag tcctgagcag     3060

cgacgagcag ttgcatgggc ccaacatgag ggaaaggaga gcccagaaca gcaaggtcga     3120

agtacagcct ggggcctcca ggactggtca cgaccttcct ggtccctggt attgactatc     3180

agcttccttg gccacctgct a                                               3201


<210> 58
<211> 3189
<212> DNA
<213> Mus musculus

<400> 58
tgcttcagtc ctgtactgtg ggatctactc cagagagaga agagcgtttg ggccctgagg       60

accctggtga aggcctacct gcgcatgcct ccagaagacc ttcagcagct tgtgctttca      120

gcagagatgg aggctgcaca gggcttcctg acgctcatgc ttcgttcctg ggctaagctg      180

aaggttcaac catccgagga gcaggccatg ggccgcctga cagccttgct gctccagcgg      240

tacccacgcc tcacctccca actctttatc gacatgtcac cgctcatccc cttcctggct      300

gtccctgacc tcatgcgctt cccaccgtcc cttttggcca acgacagtgt cctggctgcc      360

atcagggatc acagctcagg aatgaagcct gaacagaagg aggccctggc aaaacgactg      420

ctggcccctg agctgtttgg agaagtgcct gattggcccc aggagctgct gtgggcagcc      480

ctgcctctgc ttccccatct gcctctggag agctttctcc agctcagccc tcaccagatc      540

caggccctgg aggatagctg gccagtagca gatcttgggc cgggacacgc ccgacatgtg      600

cttcgtagcc tagtaaacca gagcatggag gatggggagg agcaggtgct caggcttggg      660

tccctcgcct gtttcctgag tcctgaggag ctacagagtc tggtgccctt gagtgatcca      720

atggggcctg tagaacaggg tctgctggaa tgtgcggcca atgggaccct cagcccagaa      780

ggacgggtgg catatgaact tctgggagtg ttgcgttcat ctggaggaac tgtcttaagc      840

ccccgagagc tgagggtctg ggcacctctc tttccccagc tgggcctccg cttcctgcag      900

gagctctcag agacccagct tagagccatg cttcctgccc tacagggagc cagtgtcaca      960

cctgcccagg ctgttctgtt gtttggaagg ctccttccta agcatgatct gtccctggag     1020

gaactctgct ccctgcaccc tctcctgcca ggtctcagcc cccagacact ccaggccatc     1080

cctaagagag ttctggttgg tgcttgttcc tgcctgggcc ctgaactgtc aaggctttca     1140

gcttgccaga ttgcagctct gctgcagacc tttcgggtaa aagatggtgt taaaaatatg     1200

ggtgcagcag gtgccggctc agccgtgtgc attcctgggc agcccaccac ttggccagac     1260

tgcctgcttc ccctgctccc attaaagctg ctacagctgg acgctgcagc tcttctggca     1320

aaccgaagac tctatcggca gctgccttgg tctgagcaac aggcacagtt tctctggaag     1380

aaaatgcaag tgcctaccaa cctgagcctg aggaatctgc aggctctggg caacttggca     1440

ggaggcatga cctgcgagtt tctgcagcag atcagctcaa tggttgactt tcttgatgtg     1500

gtacacatgc tctaccagct gcccactggt gttcgagaga gcctgcgggc ctgtatctgg     1560

acagagctac agcggaggat gacaatgcca gagccagagc tgaccaccct agggccagaa     1620

ctgagtgaac ttgacacaaa gctactcctg gacttgccga tccagctgat ggacagattg     1680

tccaatgatt ccattatgtt ggtggtggag atggtccaag gcgctccaga gcagctgctg     1740

gcactgaccc cactccacca gacagccttg gcagagcgag cacttaaaaa cctggctcca     1800

aaggagaccc caatctccaa agaagtgctg gagacactgg gccccttggt tggattcctg     1860

ggaatagaga gcacgcgacg gatcccttta cccattctac tgtctcatct cagtcagctg     1920

cagggcttct gcctaggaga gacatttgcc acagagctgg gatggctgct gttgcaggag     1980

cctgttcttg gaaaaccaga attgtggagc caggatgaaa tagagcaagc tggacgccta     2040

gtattcactc tgtctgctga ggctatttcc tcgatcccca gggaggcttt gggcccagag     2100

acactggaga ggcttctggg aaagcatcaa agctgggagc agagcagagt gggccatctg     2160

tgtggggagt cacagcttgc ccacaagaaa gcagctctgg tagctgggat tgtgcatcca     2220

gctgctgagg gtctccaaga gcctgtacca aactgtgcag acatacgggg aaccttccca     2280

gcggcctggt ctgcgacaca aatctcagag atggaactct cagactttga agactgcctg     2340

tcactatttg ctggagatcc aggacttggt cctgaggaac tacgggcagc catgggcaag     2400

gccaagcagt tgtggggtcc ccctcgagga ttccgtcctg agcagatctt gcagctgggc     2460

cgtctcctga taggtctagg agaacgggaa ctgcaggagc ttaccttggt ggactggggt     2520

gtgctgagca gcctggggca aatagatggc tggagttcca tgcagctccg agccgtggtc     2580

tccagtttcc taaggcagag tggtcggcat gtgagccacc tggacttcat ttatctgaca     2640

gcactgggtt acacagtctg tggattgcga ccagaggagt tacagcacat cagcagttgg     2700

gagtttagcc aagcagctct cttcctgggt agcttgcatc tcccgtgctc tgaggaacag     2760

ctggaagttc tggcctatct ccttgtgttg cctggtggct ttggcccagt cagtaactgg     2820

gggcctgaga tcttcactga aattggcaca atagcagctg gcatcccaga cctggctctt     2880

tcagcattac tgcggggaca gatccaaggc ctgactcctc ttgccatttc tgtcattcct     2940

gctcccaagt ttgcagtggt cttcaacccc atccagttat ctagtctcac caggggtcag     3000

gccgtagctg ttactcctga acagctggcc tatctgagtc ctgagcagcg gcgagcagtt     3060

gcatgggccc aacacgaagg gaaggagatc ccagagcagc tgggtcgaaa ctcagcctgg     3120

ggtctctacg actggttcca agcctcctgg gccctggcat tgcccgtcag catttttggc     3180

cacctatta                                                             3189


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Thr Leu Ala Val Pro Phe Lys 
1               5           


<210> 60
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Glu Leu Leu Ser Cys Phe Ser Pro Val 
1               5                   


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gly Ser Leu Ala Cys Phe Leu Ser Pro 
1               5                   


<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Glu Leu Leu Ala Cys Phe Ser Pro Val 
1               5                   


<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gly Pro Leu Ala Cys Phe Leu Ser Pro 
1               5                   


