                         SEQUENCE LISTING

<110>  MEMORIAL SLOAN-KETTERING CANCER CENTER
       DANIYAN, Anthony
       BRENTJENS, Renier J.
 
<120>  CHIMERIC ANTIGEN RECEPTORS WITH CD28 MUTATIONS AND USE THEREOF

<130>  072734.1189

<150>  US 62/970,401
<151>  2020-02-05

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


<210>  2
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  3
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Lys Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gly Tyr Ala Phe Ser Ser 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Tyr Pro Gly Asp Gly Asp 
1               5       


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Lys Thr Ile Ser Ser Val Val Asp Phe 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Asn Val Gly Thr Asn Val Ala 
1               5           


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ser Ala Thr Tyr Arg Asn 
1               5       


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Phe Cys Gln Gln Tyr Asn Arg Tyr 
1               5               


<210>  12
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  13
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Thr Thr Thr Thr Gly Gly Gly Thr Gly Cys Thr Gly Gly Thr Gly Gly 
1               5                   10                  15      


Thr Gly Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Thr Thr Gly Cys Thr Ala Thr Ala Gly Cys Thr Thr Gly 
        35                  40                  45              


Cys Thr Ala Gly Thr Ala Ala Cys Ala Gly Thr Gly Gly Cys Cys Thr 
    50                  55                  60                  


Thr Thr Ala Thr Thr Ala Thr Thr Thr Thr Cys Thr Gly Gly Gly Thr 
65                  70                  75                  80  


Gly 
    


<210>  14
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210>  15
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  16
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Met 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Val Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Pro 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210>  17
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Tyr Met Asn Met 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is any naturally occurring amino acid, but not an aspartic acid
       (N); In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, D, C, E, Q, G, H, I, K, M, F, P, 
       S, T, W, Y, V, and L.

<400>  20

Tyr Met Xaa Met 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is any naturally occurring amino acid, but is not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, D, C, E, Q, G, H, I, K, F, P, 
       S, T, W, Y, V, and L.

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is any naturally occurring amino acid, but is not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, D, C, E, Q, G, H, I, K, F, P, 
       S, T, W, Y, V, and L.

<400>  21

Tyr Xaa Asn Xaa 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Tyr Glu Asn Val 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Tyr Ser Asn Val 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Tyr Lys Asn Leu 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Tyr Glu Asn Gln 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Tyr Lys Asn Ile 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Tyr Ile Asn Gln 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Tyr His Asn Lys 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Tyr Val Asn Gln 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Tyr Leu Asn Pro 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Tyr Leu Asn Thr 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Tyr Met Asp Met 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is any naturally occurring amino acid, but not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, C, E, Q, G, H, I, K, N, F, P, 
       S, T, W, Y, V, and L.

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is any naturally occurring amino acid, but not an aspartic acid
       (N).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, D, C, E, Q, G, H, I, K, M, F, P, 
       S, T, W, Y, V, and L.

<400>  33

Tyr Xaa Xaa Met 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Tyr Thr His Met 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Tyr Val Leu Met 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Tyr Ile Ala Met 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Tyr Met Arg Met 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is any naturally occurring amino acid, but not a methionine 
       (M); In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, C, E, Q, G, H, I, K, N, F, P, 
       S, T, W, Y, V, and L.

<400>  38

Tyr Met Asn Xaa 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is any naturally occurring amino acid, but not a methionine 
       (M); In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, C, E, Q, G, H, I, K, N, F, P, 
       S, T, W, Y, V, and L.

<400>  39

Tyr Xaa Asn Met 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Tyr Met Asn Val 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Tyr Glu Asn Met 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Tyr Met Asn Gln 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X is any naturally occurring amino acid, but not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of A, R, N, D, C, E, Q, G, H, I, K, F, P, S, T, W, Y, 
       V, and L.

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is any naturally occurring amino acid, but is not an aspartic 
       acid (N). In certain embodiments, x is selected from the group 
       consisting of A, R, D, C, E, Q, G, H, I, K, M, F, P, S, T, W, Y, 
       V, and L.

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is any naturally occurring amino acid, but not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of A, R, N, D, C, E, Q, G, H, I, K, F, P, S, T, W, Y, 
       V, and L.

<400>  43

Tyr Xaa Xaa Xaa 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Tyr Gly Gly Gly 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Tyr Ala Ala Ala 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Tyr Phe Phe Phe 
1               


<210>  47
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Glu Asn Val Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  48
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Lys Asn Ile Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  49
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asp Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  50
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  51
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asp Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  52
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactacat ggatatgact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  53
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Glu Asn Val Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  54
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactatga aaatgtgact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg ctag                                            1404


<210>  55
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Lys Asn Ile Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  56
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactataa aaacattact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  57
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Ser Asn Val Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  58
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactactc aaatgttact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  59
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Lys Asn Leu Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  60
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactacaa aaacttgact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  61
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser 
    130                 135                 140                 


Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr Arg Asn 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro 
                245                 250                 255     


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
            260                 265                 270         


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Gly Gly Gly Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  62
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
gaggtgaagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtca agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcggcctaac atctgaggac tctgcggtct atttctgtgc aagaaagacc      300

attagttcgg tagtagattt ctactttgac tactggggcc aagggaccac ggtcaccgtc      360

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgag      420

ctcacccagt ctccaaaatt catgtccaca tcagtaggag acagggtcag cgtcacctgc      480

aaggccagtc agaatgtggg tactaatgta gcctggtatc aacagaaacc aggacaatct      540

cctaaaccac tgatttactc ggcaacctac cggaacagtg gagtccctga tcgcttcaca      600

ggcagtggat ctgggacaga tttcactctc accatcacta acgtgcagtc taaagacttg      660

gcagactatt tctgtcaaca atataacagg tatccgtaca cgtccggagg ggggaccaag      720

ctggagatca aacgggcggc cgcaattgaa gttatgtatc ctcctcctta cctagacaat      780

gagaagagca atggaaccat tatccatgtg aaagggaaac acctttgtcc aagtccccta      840

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      900

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      960

ctcctgcaca gtgactacgg tggagggact ccccgccgcc ccgggcccac ccgcaagcat     1020

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc     1080

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat     1140

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1200

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1260

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1320

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1380

atgcaggccc tgccccctcg c                                               1401


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Tyr Gly Gly Gly 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Tyr Ser Asn Val 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is any naturally occurring amino acid, but is not an aspartic 
       acid (N).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, D, C, E, Q, G, H, I, K, M, F, P, 
       S, T, W, Y, V, and L.

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is any naturally occurring amino acid, but is not a methionine 
       (M).  In certain embodiments, x is selected from the group 
       consisting of amino acids A, R, N, C, E, Q, G, H, I, K, N, F, P, 
       S, T, W, Y, V, and L.

<400>  65

Tyr Met Xaa Xaa 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Tyr Asp Asn Asp 
1               


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Tyr Glu Asn Ile 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Tyr Glu Asn Leu 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Tyr Glu Thr Val 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Tyr Gln Gln Gln 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Tyr His Ala Glu 
1               


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Tyr Lys Asn Gln 
1               


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73

Tyr Lys Asn Val 
1               


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Tyr Leu Asp Leu 
1               


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Tyr Leu Ile Pro 
1               


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Tyr Leu Arg Val 
1               


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Tyr Met Ala Pro 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Tyr Met Asn Leu 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Tyr Met Pro Met 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Tyr Met Ser Met 
1               


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Tyr Ser Asn Met 
1               


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Tyr Thr Ala Val 
1               


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Tyr Val Glu Met 
1               


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Tyr Val His Val 
1               


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Tyr Val Lys Met 
1               


<210>  86
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Tyr Val Pro Met 
1               


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Tyr Ala Asn Gly 
1               


