                               SEQUENCE LISTING

<110> NAVAUX, INC.
 
<120> ANTI-HEPSIN ANTIBODIES AND USES THEREOF

<130> 55156-701.601

<140> PCT/US2021/016409
<141> 2021-02-03

<150> 62/970,626
<151> 2020-02-05

<160> 49    

<170> PatentIn version 3.5

<210> 1
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn 
        35                  40                  45              


Lys Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Gly Ser Thr Ile Ile Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Arg Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Arg Ala Asn Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135     


<210> 2
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Arg Val Leu Ile Leu Leu Cys Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Ile Leu 
    50                  55                  60                  


Glu Trp Met Ala Tyr Ile His Tyr Asn Gly Asn Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Phe Cys Ala Arg Ala Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 3
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln 
            20                  25                  30          


Pro Gly Glu Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Ala Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu His Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Gly Ser Asn Trp Asp Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135     


<210> 4
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Ser Ser Asn Phe His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr His Arg Ser Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210> 5
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Asp Ser Gln Ala Gln Val Leu Ile Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Glu Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Arg Ile Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Arg Ala Asn Trp Tyr Tyr Phe Asp Tyr 
1               5                   


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
His Gln Tyr His Arg Ser Pro Arg Thr 
1               5                   


<210> 8
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ala Asp Phe 
1           


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ser Asn Trp Asp Tyr Phe Asp Tyr 
1               5               


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Lys Gln Ser Tyr Asn Leu Trp Thr 
1               5               


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Glu Ile Asn Pro Asp Gly Ser Thr Ile Ile Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210> 13
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Tyr Ile His Tyr Asn Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Tyr Ile Ser Ser Gly Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Lys Tyr Trp Met Ser 
1               5   


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Thr Ala Ser Ser Ser Val Ser Ser Ser Asn Phe His 
1               5                   10          


<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ser Gly Tyr Ser Trp His 
1               5       


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ser Phe Gly Met His 
1               5   


<210> 20
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Ile Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210> 21
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt taataaatac tggatgagtt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatggca gtacgatcat ctatacgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca gaaatactct gtacctgcaa      300

atgagcaaag tgagatctga ggacacagcc ctttattact gtgcaagacg ggctaactgg      360

tactactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210> 22
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
atgagagtgc tgattctttt gtgcctgttc acagcctttc ctggtatcct gtctgatgtg       60

cagcttcagg agtcaggacc tgacctggtg aaaccttctc agtcactttc actcacctgc      120

actgtcactg gctactccat caccagtggt tatagctggc actggatccg gcagtttcca      180

ggaaacatac tggaatggat ggcctacata cactacaatg gtaacactaa ctacaaccca      240

tctctcaaaa gtcggatctc tatcactcga gacacctcca agaaccagtt cttcctgcag      300

ttgaattctg tgactactga ggacactgcc acatatttct gtgcaagagc cgatttctgg      360

ggccaaggca ccactctcac agtctcctca                                       390


<210> 23
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
atggactcca ggctcaattt agttttcctt gtccttattt taaaaggtgt ccagtgtgat       60

gtgcagctgg tggagtctgg gggagactta gtgcagcctg gagagtcccg gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tttggaatgc actgggttcg tcaggctcca      180

gagaaggggc tggagtgggt cgcatacatt agtagtggca gtagtgccat ctactatgca      240

gacacagtga agggccgatt caccatctcc agagacaatc ccaagaacac cctgttccta      300

cacatgacca gtctaaggtc tgaggacacg gccatatatt actgtgcagg aagcaactgg      360

gactactttg actactgggg ccaaggcacc actctcacag tctcctca                   408


<210> 24
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctct aggggaacgg      120

gtcaccatga cctgcactgc cagctcaagt gtaagttcca gtaactttca ctggtaccag      180

cagaagccag gatcctcccc caaactctgg atttatagca cctccaacct ggcttctgga      240

gtcccaactc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcagc      300

atggaggctg aagatgctgc cacttattac tgccaccagt atcatcgttc cccacggacg      360

ttcggtggag gcaccaagct ggaaatcaaa                                       390


<210> 25
<211> 396
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atggattcac aggcccaggt tcttatattg ctgctgctat gggtatctgg tacctgtgag       60

gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      120

atgagctgca aatccagtca gagtctgcta aacagtagaa tccgaaagaa ctacttggct      180

tggtaccagc agaaaccagg gcagtctcct aaattgttga tctactgggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      300

atcagcagtg tgcaggctga ggacctggca gtttattact gcaaacaatc ttataatctg      360

tggacgttcg gtggaggcac caagctggaa atcaaa                                396


<210> 26
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
cgggctaact ggtactactt tgactac                                           27


<210> 27
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gccgatttc                                                                9


<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
agcaactggg actactttga ctac                                              24


<210> 29
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
caccagtatc atcgttcccc acggacg                                           27


<210> 30
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
aaacaatctt ataatctgtg gacg                                              24


<210> 31
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gaaattaatc cagatggcag tacgatcatc tatacgccat ctctaaagga t                51


<210> 32
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
tacatacact acaatggtaa cactaactac aacccatctc tcaaaagt                    48


<210> 33
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
tacattagta gtggcagtag tgccatctac tatgcagaca cagtgaaggg c                51


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
agcacctcca acctggcttc t                                                 21


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
aaacaatctt ataatctgtg gacg                                              24


<210> 36
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
aaatactgga tgagt                                                        15


<210> 37
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
agtggttata gctggcac                                                     18


<210> 38
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
agctttggaa tgcac                                                        15


<210> 39
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
actgccagct caagtgtaag ttccagtaac tttcac                                 36


<210> 40
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
aaatccagtc agagtctgct aaacagtaga atccgaaaga actacttggc t                51


<210> 41
<211> 417
<212> PRT
<213> Homo sapiens

<400> 41
Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu 
    


<210> 42
<211> 753
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
cgggacacca gcttgggccg gtggccgtgg caagtcagcc ttcgctatga tggagcacac       60

ctctgtgggg gatccctgct ctccggggac tgggtgctga cagccgccca ctgcttcccg      120

gagcggaacc gggtcctgtc ccgatggcga gtgtttgccg gtgccgtggc ccaggcctct      180

ccccacggtc tgcagctggg ggtgcaggct gtggtctacc acgggggcta tcttcccttt      240

cgggacccca acagcgagga gaacagcaac gatattgccc tggtccacct ctccagtccc      300

ctgcccctca cagaatacat ccagcctgtg tgcctcccag ctgccggcca ggccctggtg      360

gatggcaaga tctgtaccgt gacgggctgg ggcaacacgc agtactatgg ccaacaggcc      420

ggggtactcc aggaggctcg agtccccata atcagcaatg atgtctgcaa tggcgctgac      480

ttctatggaa accagatcaa gcccaagatg ttctgtgctg gctaccccga gggtggcatt      540

gatgcctgcc agggcgacag cggtggtccc tttgtgtgtg aggacagcat ctctcggacg      600

ccacgttggc ggctgtgtgg cattgtgagt tggggcactg gctgtgccct ggcccagaag      660

ccaggcgtct acaccaaagt cagtgacttc cgggagtgga tcttccaggc cataaagact      720

cactccgaag ccagcggcat ggtgacccag ctc                                   753


<210> 43
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp Gln Val Ser Leu Arg Tyr 
1               5                   10                  15      


Asp Gly Ala His Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp Val 
            20                  25                  30          


Leu Thr Ala Ala His Cys Phe Pro Glu Arg Asn Arg Val Leu Ser Arg 
        35                  40                  45              


Trp Arg Val Phe Ala Gly Ala Val Ala Gln Ala Ser Pro His Gly Leu 
    50                  55                  60                  


Gln Leu Gly Val Gln Ala Val Val Tyr His Gly Gly Tyr Leu Pro Phe 
65                  70                  75                  80  


Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu Val His 
                85                  90                  95      


Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys Leu 
            100                 105                 110         


Pro Ala Ala Gly Gln Ala Leu Val Asp Gly Lys Ile Cys Thr Val Thr 
        115                 120                 125             


Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu Gln 
    130                 135                 140                 


Glu Ala Arg Val Pro Ile Ile Ser Asn Asp Val Cys Asn Gly Ala Asp 
145                 150                 155                 160 


Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr Pro 
                165                 170                 175     


Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe Val 
            180                 185                 190         


Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly Ile 
        195                 200                 205             


Val Ser Trp Gly Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly Val Tyr 
    210                 215                 220                 


Thr Lys Val Ser Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys Thr 
225                 230                 235                 240 


His Ser Glu Ala Ser Gly Met Val Thr Gln Leu 
                245                 250     


<210> 44
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met Val 
1               5                   10                  15      


Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg Ser 
            20                  25                  30          


Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu Arg 
        35                  40                  45              


Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn Gly 
    50                  55                  60                  


Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr Gln 
65                  70                  75                  80  


Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg Phe 
                85                  90                  95      


Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val Asp 
            100                 105                 110         


Arg Leu Val Pro Arg Gly Ser Ile Val Gly Gly Arg Asp Thr Ser Leu 
        115                 120                 125             


Gly Arg Trp Pro Trp Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu 
    130                 135                 140                 


Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His 
145                 150                 155                 160 


Cys Phe Pro Glu Arg Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala 
                165                 170                 175     


Gly Ala Val Ala Gln Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln 
            180                 185                 190         


Ala Val Val Tyr His Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser 
        195                 200                 205             


Glu Glu Asn Ser Asn Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu 
    210                 215                 220                 


Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln 
225                 230                 235                 240 


Ala Leu Val Asp Gly Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr 
                245                 250                 255     


Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro 
            260                 265                 270         


Ile Ile Ser Asn Asp Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln 
        275                 280                 285             


Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp 
    290                 295                 300                 


Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr 
                325                 330                 335     


Gly Cys Ala Leu Ala Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp 
            340                 345                 350         


Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser 
        355                 360                 365             


Gly Met Val Thr Gln Leu His His His His His His 
    370                 375                 380 


<210> 45
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Ile Val Gly Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp 
                165                 170                 175     


Gln Val Ser Leu Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu 
            180                 185                 190         


Leu Ser Gly Asp Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg 
        195                 200                 205             


Asn Arg Val Leu Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln 
    210                 215                 220                 


Ala Ser Pro His Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His 
225                 230                 235                 240 


Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn 
                245                 250                 255     


Asp Ile Ala Leu Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr 
            260                 265                 270         


Ile Gln Pro Val Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly 
        275                 280                 285             


Lys Ile Cys Thr Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln 
    290                 295                 300                 


Gln Ala Gly Val Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp 
305                 310                 315                 320 


Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met 
                325                 330                 335     


Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp 
            340                 345                 350         


Ser Gly Gly Pro Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg 
        355                 360                 365             


Trp Arg Leu Cys Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala 
    370                 375                 380                 


Gln Lys Pro Gly Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile 
385                 390                 395                 400 


Phe Gln Ala Ile Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln 
                405                 410                 415     


Leu Gly Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Ser 
            420                 425                 430         


Asp Tyr Lys Asp Asp Asp Asp Lys 
        435                 440 


<210> 46
<211> 446
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Ala Gln Lys Glu Gly Gly Arg Thr Val Pro Cys Cys Ser Arg Pro 
1               5                   10                  15      


Lys Val Ala Ala Leu Thr Ala Gly Thr Leu Leu Leu Leu Thr Ala Ile 
            20                  25                  30          


Gly Ala Ala Ser Trp Ala Ile Val Ala Val Leu Leu Arg Ser Asp Gln 
        35                  40                  45              


Glu Pro Leu Tyr Pro Val Gln Val Ser Ser Ala Asp Ala Arg Leu Met 
    50                  55                  60                  


Val Phe Asp Lys Thr Glu Gly Thr Trp Arg Leu Leu Cys Ser Ser Arg 
65                  70                  75                  80  


Ser Asn Ala Arg Val Ala Gly Leu Ser Cys Glu Glu Met Gly Phe Leu 
                85                  90                  95      


Arg Ala Leu Thr His Ser Glu Leu Asp Val Arg Thr Ala Gly Ala Asn 
            100                 105                 110         


Gly Thr Ser Gly Phe Phe Cys Val Asp Glu Gly Arg Leu Pro His Thr 
        115                 120                 125             


Gln Arg Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg Gly Arg 
    130                 135                 140                 


Phe Leu Ala Ala Ile Cys Gln Asp Cys Gly Arg Arg Lys Leu Pro Val 
145                 150                 155                 160 


Asp Arg Leu Val Pro Arg Gly Ser Ile Val Gly Gly Arg Asp Thr Ser 
                165                 170                 175     


Leu Gly Arg Trp Pro Trp Gln Val Ser Leu Arg Tyr Asp Gly Ala His 
            180                 185                 190         


Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp Trp Val Leu Thr Ala Ala 
        195                 200                 205             


His Cys Phe Pro Glu Arg Asn Arg Val Leu Ser Arg Trp Arg Val Phe 
    210                 215                 220                 


Ala Gly Ala Val Ala Gln Ala Ser Pro His Gly Leu Gln Leu Gly Val 
225                 230                 235                 240 


Gln Ala Val Val Tyr His Gly Gly Tyr Leu Pro Phe Arg Asp Pro Asn 
                245                 250                 255     


Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu Val His Leu Ser Ser Pro 
            260                 265                 270         


Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val Cys Leu Pro Ala Ala Gly 
        275                 280                 285             


Gln Ala Leu Val Asp Gly Lys Ile Cys Thr Val Thr Gly Trp Gly Asn 
    290                 295                 300                 


Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val Leu Gln Glu Ala Arg Val 
305                 310                 315                 320 


Pro Ile Ile Ser Asn Asp Val Cys Asn Gly Ala Asp Phe Tyr Gly Asn 
                325                 330                 335     


Gln Ile Lys Pro Lys Met Phe Cys Ala Gly Tyr Pro Glu Gly Gly Ile 
            340                 345                 350         


Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Phe Val Cys Glu Asp Ser 
        355                 360                 365             


Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys Gly Ile Val Ser Trp Gly 
    370                 375                 380                 


Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly Val Tyr Thr Lys Val Ser 
385                 390                 395                 400 


Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile Lys Thr His Ser Glu Ala 
                405                 410                 415     


Ser Gly Met Val Thr Gln Leu Gly Thr Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Ser Gly Gly Gly Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
        435                 440                 445     


<210> 47
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 47
His His His His His His 
1               5       


<210> 48
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Gly Arg Asp Thr Ser Leu Gly Arg Trp Pro Trp Gln Val Ser Leu 
            20                  25                  30          


Arg Tyr Asp Gly Ala His Leu Cys Gly Gly Ser Leu Leu Ser Gly Asp 
        35                  40                  45              


Trp Val Leu Thr Ala Ala His Cys Phe Pro Glu Arg Asn Arg Val Leu 
    50                  55                  60                  


Ser Arg Trp Arg Val Phe Ala Gly Ala Val Ala Gln Ala Ser Pro His 
65                  70                  75                  80  


Gly Leu Gln Leu Gly Val Gln Ala Val Val Tyr His Gly Gly Tyr Leu 
                85                  90                  95      


Pro Phe Arg Asp Pro Asn Ser Glu Glu Asn Ser Asn Asp Ile Ala Leu 
            100                 105                 110         


Val His Leu Ser Ser Pro Leu Pro Leu Thr Glu Tyr Ile Gln Pro Val 
        115                 120                 125             


Cys Leu Pro Ala Ala Gly Gln Ala Leu Val Asp Gly Lys Ile Cys Thr 
    130                 135                 140                 


Val Thr Gly Trp Gly Asn Thr Gln Tyr Tyr Gly Gln Gln Ala Gly Val 
145                 150                 155                 160 


Leu Gln Glu Ala Arg Val Pro Ile Ile Ser Asn Asp Val Cys Asn Gly 
                165                 170                 175     


Ala Asp Phe Tyr Gly Asn Gln Ile Lys Pro Lys Met Phe Cys Ala Gly 
            180                 185                 190         


Tyr Pro Glu Gly Gly Ile Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro 
        195                 200                 205             


Phe Val Cys Glu Asp Ser Ile Ser Arg Thr Pro Arg Trp Arg Leu Cys 
    210                 215                 220                 


Gly Ile Val Ser Trp Gly Thr Gly Cys Ala Leu Ala Gln Lys Pro Gly 
225                 230                 235                 240 


Val Tyr Thr Lys Val Ser Asp Phe Arg Glu Trp Ile Phe Gln Ala Ile 
                245                 250                 255     


Lys Thr His Ser Glu Ala Ser Gly Met Val Thr Gln Leu Gly Thr Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Ser Asp Tyr Lys Asp 
        275                 280                 285             


Asp Asp Asp Lys 
    290         


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


