                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
        
<120>  Split CRISPR-Cas for Biological Signal Integration

<130>  078430-515001WO

<150>  US 62/970,150
<151>  2020-02-04

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  LbCas12a parental protein

<400>  1

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys 
    1220                 1225         


<210>  2
<211>  1227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  dLbCas12a (D832A), nuclease-dead

<400>  2

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys 
    1220                 1225         


<210>  3
<211>  3819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  dLbCas12a (HA tagged, 2XNLS)

<400>  3
atgagcaagc tggagaagtt tacaaactgc tactccctgt ctaagaccct gaggttcaag       60

gccatccctg tgggcaagac ccaggagaac atcgacaata agcggctgct ggtggaggac      120

gagaagagag ccgaggatta taagggcgtg aagaagctgc tggatcgcta ctatctgtct      180

tttatcaacg acgtgctgca cagcatcaag ctgaagaatc tgaacaatta catcagcctg      240

ttccggaaga aaaccagaac cgagaaggag aataaggagc tggagaacct ggagatcaat      300

ctgcggaagg agatcgccaa ggccttcaag ggcaacgagg gctacaagtc cctgtttaag      360

aaggatatca tcgagacaat cctgccagag ttcctggacg ataaggacga gatcgccctg      420

gtgaacagct tcaatggctt taccacagcc ttcaccggct tctttgataa cagagagaat      480

atgttttccg aggaggccaa gagcacatcc atcgccttca ggtgtatcaa cgagaatctg      540

acccgctaca tctctaatat ggacatcttc gagaaggtgg acgccatctt tgataagcac      600

gaggtgcagg agatcaagga gaagatcctg aacagcgact atgatgtgga ggatttcttt      660

gagggcgagt tctttaactt tgtgctgaca caggagggca tcgacgtgta taacgccatc      720

atcggcggct tcgtgaccga gagcggcgag aagatcaagg gcctgaacga gtacatcaac      780

ctgtataatc agaaaaccaa gcagaagctg cctaagttta agccactgta taagcaggtg      840

ctgagcgatc gggagtctct gagcttctac ggcgagggct atacatccga tgaggaggtg      900

ctggaggtgt ttagaaacac cctgaacaag aacagcgaga tcttcagctc catcaagaag      960

ctggagaagc tgttcaagaa ttttgacgag tactctagcg ccggcatctt tgtgaagaac     1020

ggccccgcca tcagcacaat ctccaaggat atcttcggcg agtggaacgt gatccgggac     1080

aagtggaatg ccgagtatga cgatatccac ctgaagaaga aggccgtggt gaccgagaag     1140

tacgaggacg atcggagaaa gtccttcaag aagatcggct ccttttctct ggagcagctg     1200

caggagtacg ccgacgccga tctgtctgtg gtggagaagc tgaaggagat catcatccag     1260

aaggtggatg agatctacaa ggtgtatggc tcctctgaga agctgttcga cgccgatttt     1320

gtgctggaga agagcctgaa gaagaacgac gccgtggtgg ccatcatgaa ggacctgctg     1380

gattctgtga agagcttcga gaattacatc aaggccttct ttggcgaggg caaggagaca     1440

aacagggacg agtccttcta tggcgatttt gtgctggcct acgacatcct gctgaaggtg     1500

gaccacatct acgatgccat ccgcaattat gtgacccaga agccctactc taaggataag     1560

ttcaagctgt attttcagaa ccctcagttc atgggcggct gggacaagga taaggagaca     1620

gactatcggg ccaccatcct gagatacggc tccaagtact atctggccat catggataag     1680

aagtacgcca agtgcctgca gaagatcgac aaggacgatg tgaacggcaa ttacgagaag     1740

atcaactata agctgctgcc cggccctaat aagatgctgc caaaggtgtt cttttctaag     1800

aagtggatgg cctactataa ccccagcgag gacatccaga agatctacaa gaatggcaca     1860

ttcaagaagg gcgatatgtt taacctgaat gactgtcaca agctgatcga cttctttaag     1920

gatagcatct cccggtatcc aaagtggtcc aatgcctacg atttcaactt ttctgagaca     1980

gagaagtata aggacatcgc cggcttttac agagaggtgg aggagcaggg ctataaggtg     2040

agcttcgagt ctgccagcaa gaaggaggtg gataagctgg tggaggaggg caagctgtat     2100

atgttccaga tctataacaa ggacttttcc gataagtctc acggcacacc caatctgcac     2160

accatgtact tcaagctgct gtttgacgag aacaatcacg gacagatcag gctgagcgga     2220

ggagcagagc tgttcatgag gcgcgcctcc ctgaagaagg aggagctggt ggtgcaccca     2280

gccaactccc ctatcgccaa caagaatcca gataatccca agaaaaccac aaccctgtcc     2340

tacgacgtgt ataaggataa gaggttttct gaggaccagt acgagctgca catcccaatc     2400

gccatcaata agtgccccaa gaacatcttc aagatcaata cagaggtgcg cgtgctgctg     2460

aagcacgacg ataaccccta tgtgatcggc atcgccaggg gcgagcgcaa tctgctgtat     2520

atcgtggtgg tggacggcaa gggcaacatc gtggagcagt attccctgaa cgagatcatc     2580

aacaacttca acggcatcag gatcaagaca gattaccact ctctgctgga caagaaggag     2640

aaggagaggt tcgaggcccg ccagaactgg acctccatcg agaatatcaa ggagctgaag     2700

gccggctata tctctcaggt ggtgcacaag atctgcgagc tggtggagaa gtacgatgcc     2760

gtgatcgccc tggaggacct gaactctggc tttaagaata gccgcgtgaa ggtggagaag     2820

caggtgtatc agaagttcga gaagatgctg atcgataagc tgaactacat ggtggacaag     2880

aagtctaatc cttgtgcaac aggcggcgcc ctgaagggct atcagatcac caataagttc     2940

gagagcttta agtccatgtc tacccagaac ggcttcatct tttacatccc tgcctggctg     3000

acatccaaga tcgatccatc taccggcttt gtgaacctgc tgaaaaccaa gtataccagc     3060

atcgccgatt ccaagaagtt catcagctcc tttgacagga tcatgtacgt gcccgaggag     3120

gatctgttcg agtttgccct ggactataag aacttctctc gcacagacgc cgattacatc     3180

aagaagtgga agctgtactc ctacggcaac cggatcagaa tcttccggaa tcctaagaag     3240

aacaacgtgt tcgactggga ggaggtgtgc ctgaccagcg cctataagga gctgttcaac     3300

aagtacggca tcaattatca gcagggcgat atcagagccc tgctgtgcga gcagtccgac     3360

aaggccttct actctagctt tatggccctg atgagcctga tgctgcagat gcggaacagc     3420

atcacaggcc gcaccgacgt ggattttctg atcagccctg tgaagaactc cgacggcatc     3480

ttctacgata gccggaacta tgaggcccag gagaatgcca tcctgccaaa gaacgccgac     3540

gccaatggcg cctataacat cgccagaaag gtgctgtggg ccatcggcca gttcaagaag     3600

gccgaggacg agaagctgga taaggtgaag atcgccatct ctaacaagga gtggctggag     3660

tacgcccaga ccagcgtgaa gcacggatcc tatccctatg acgtgcccga ttatgccagc     3720

ctgggcagcg gctcccccaa gaaaaaacgc aaggtggaag atcctaagaa aaagcggaaa     3780

gtggacggca ttggtagtgg gagcaacggc agcagcctc                            3819


<210>  4
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  miniVPR

<400>  4
gatgctttag acgattttga cttagatatg cttggttcag acgcgttaga cgacttcgac       60

ctagacatgt taggctcaga tgcattggac gacttcgatt tagatatgtt gggctccgat      120

gccctagatg actttgatct agatatgcta ggtagtccca aaaagaagag gaaagtggga      180

tccgtccttc cgcaagcgcc tgccccagcg cctgcaccgg caatggtgtc cgccctcgca      240

caggcccctg cgcccgtccc cgtgctcgcg cctggaccgc cccaggcggt cgctccaccg      300

gctccgaagc cgacgcaggc cggagaggga acactctccg aagcacttct tcaactccag      360

tttgatgacg aggatcttgg agcactcctt ggaaactcga cagaccctgc ggtgtttacc      420

gacctcgcgt cagtagataa ctccgaattt cagcagcttt tgaaccaggg tatcccggtc      480

gcgccacata caacggagcc catgttgatg gaataccccg aagcaatcac gagacttgtg      540

acgggagcgc agcggcctcc cgatcccgca cccgcacctt tgggggcacc tggcctccct      600

aacggacttt tgagcggcga cgaggatttc tcctccatcg ccgatatgga tttctcagcc      660

ttgctgtcag gctctggcag cggcagcgac ctttcccatc cgcccccaag gggccatctg      720

gatgagctga caaccacact tgagtccatg accgaggatc tgaacctgga ctcacccctg      780

accccggaat tgaacgagat tctggatacc ttcctgaacg acgagtgcct cttgcatgcc      840

atgcatatca gcacaggact gtccatcttc gacacatctc tgttt                      885


<210>  5
<211>  177
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  EE12RR345L

<400>  5
ggaggaggtg gtggaggtgg aggtggaggt actagtctgg agatcgaggc cgccttcctg       60

gagcgcgaga acaccgccct ggagacccgc gtggccgagc tgcgccagcg cgtgcagcgc      120

ctgcgcaacc gcgtgagcca gaaccgcacc cgctacggcc ccctgggcgg cggcaag         177


<210>  6
<211>  180
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  RR12EE345L

<400>  6
atgctggaga tccgcgccgc cttcctgcgc cagcgcaaca ccgccctgcg caccgaggtg       60

gccgagctgg agcaggaggt gcagcgcctg gagaacgagg tgagccagta cgagacccgc      120

tacggccccc tgggcggcgg caaggctagc ggaggaggtg gtggaggtgg aggtggaggt      180


<210>  7
<211>  306
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DnaE N-intein

<400>  7
tgtctgtcat acgaaactga gatactgacg gtggaatatg gtctccttcc tattgggaaa       60

atagtggaaa agaggatcga gtgtacggtt tactcagtgg acaacaatgg gaatatctat      120

acgcaacctg tcgctcagtg gcatgatcga ggggaacagg aggtgtttga gtactgtttg      180

gaggacggtt ctcttattcg ggctactaag gaccacaagt ttatgacagt tgatggtcag      240

atgttgccca tcgacgagat atttgagcgg gaactcgatt tgatgcgggt tgataatctg      300

ccgaat                                                                 306


<210>  8
<211>  105
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  DnaE C-intein

<400>  8
atgataaaga tcgccactcg gaagtatttg gggaaacaga acgtgtatga tattggtgtc       60

gagagagacc acaactttgc acttaagaat gggttcatag cgtct                      105


<210>  9
<211>  525
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  AcrVA1

<400>  9
atgtcaaagg ctatgtatga agccaaagaa cgatatgcga agaagaagat gcaggagaac       60

actaagatag acactctcac cgatgagcag catgacgctc tcgcccagct ttgcgcgttt      120

agacataagt ttcattctaa caaagattcc ctgtttcttt ccgaatcagc gttcagtggg      180

gagtttagtt tcgagatgca gtctgacgag aactccaagt tgagggaagt aggactcccc      240

acaatcgaat ggtcctttta cgacaattct cacatacccg acgacagctt tagagagtgg      300

ttcaattttg ctaactattc tgagctttca gaaacaatac aagagcaggg tcttgaactc      360

gacctggatg atgacgaaac ctacgagctg gtctatgatg agctttatac agaggcgatg      420

ggagaatacg aggaattgaa ccaggatata gagaaatacc ttcgcagaat agatgaggaa      480

catggcacgc aatactgtcc aactggtttt gcgcggctga gataa                      525


<210>  10
<211>  1144
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  RRM2 promoter

<400>  10
aatggcagag gcggggtctc actatgttgc ccaggatggt ctccagctcc tggcctcaaa       60

caatcctcct gccttggcct cccaaagtgc tgggattaca ggcgtgagcc accgcgccca      120

gccacagttt gcaattctta aggcaagggt gacaataggg gtcaggggtc tgacaggaga      180

caggatttct gtggaaaact gcaccaaggg ccttctcgcc atgtcccgta gtttgaaggt      240

ttacaaagga ctgcacattt tacatgagtc atctcaacga acgctctcct caccgcatta      300

acagtccacg cggttacgag tcccatttta ctcacgggga caccgaatct gtaagaagcc      360

tggtcgcttg tcccagcaaa acgagccacg gggctcagcg gccctaactt ttaggctgta      420

gggtcctcgc cgaccacccc gccaaaatgt caggcctcgg ggcccttgca cccccaccgc      480

agggacacgg atcgaaaggg tcgcagcaac gcctcccccg cacccaggag cgttttccag      540

gcctttgcac caacctcgtt ggctaagccc cctgcccggc ggcggcccgg ctgggaggag      600

gtgctttcgg gaggcggggc cgcggcccgg ggatcctctc gcgcccgcgg gctccaatcg      660

ctgctcctca cgcaatccta aacggttccc gggcgaaccg gggcccgcgc gcgccaaggc      720

cgccgagacc ctcaggggct gcggccctgg tcccgcggga cctgtggggg cctgggcggc      780

ggcgcccccg acccagccag cggacgggcc ggggggggaa ccgggaggtc ccggggggcg      840

tccacggggg tgtccccggg ggtctccgga aggcgccggc ggaggctccc gcgctgcgct      900

tgaaaatcgc gcgcggcccc gcggccagcc tgggtagggg caaggcgcag ccaatgggaa      960

gggtcggagg catggcacag ccaatgggaa gggccggggc accaaagcca atgggaaggg     1020

ccgggagcgc gcggcgcggg agatttaaag gctgctggag tgaggggtcg cccgtgcacc     1080

ctgtcccagc cgtcctgtcc tggctgctcg ctctgcttcg ctgcgcctcc accgtacgac     1140

catg                                                                  1144


<210>  11
<211>  226
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Hypoxia-inducible promoter

<400>  11
gaccttgagt acgtgcgtct ctgcacgtat ggcgattaag accttgagta cgtgcgtctc       60

tgcacgtatg gcgattaaga ccttgagtac gtgcgtctct gcacgtatgg cgattaagac      120

cttgagtacg tgcgtctctg cacgtatggc gattaatcat atgctctaga gggtatataa      180

tgggggccac tagtctacta ccagaaagct tacgcgtacg accatg                     226


<210>  12
<211>  410
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  TRE3G promoter

<400>  12
tgatatctcc accccacagt ggtttactcc ctatcagtga tagagaacgt atgaagagtt       60

tactccctat cagtgataga gaacgtatgc agactttact ccctatcagt gatagagaac      120

gtataaggag tttactccct atcagtgata gagaacgtat gaccagttta ctccctatca      180

gtgatagaga acgtatctac agtttactcc ctatcagtga tagagaacgt atatccagtt      240

tactccctat cagtgataga gaacgtataa gctttaggcg tgtacggtgg gcgcctataa      300

aagcagagct cgtttagtga accgtcagat cgcctggagc aattccacaa cacttttgtc      360

ttataccaac tttccgtacc acttcctacc ctcgtaaaga attcaccatg                 410


<210>  13
<211>  1264
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CMV5-CuO

<400>  13
agactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt       60

tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc      120

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac      180

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      240

tgccaagtcc gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc      300

agtacatgac cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      360

ttaccatggt gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac      420

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc      480

aacgggactt tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcaagcttg      540

ccgggtcgag gtaggcgtgt acggtgggag gcctatataa gcaaccggta taatacaaac      600

agaccagatt gtctgtttgt taccggtgtt tagtgaaccg ggcgcgcctc atatcgcctg      660

gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat ccagcctccg      720

cggtcactct cttccgcatc gctgtctgcg agggccagct gttgggctcg cggttgagga      780

caaactcttc gcggtctttc cagtactctt ggatcggaaa cccgtcggcc tccgaacggt      840

actccgccac cgagggacct gagccagtcc gcatcgaccg gatcggaaaa cctctcgaga      900

aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg cggcagcggg      960

tggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa gtaggcggtc     1020

ttgagccggc ggatggtcga ggtgaggtgt ggcaggcttg agatccagct gttggggtga     1080

gtactccctc tcaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga     1140

ggaggatttg atattcacct ggcccgatct ggccatacac ttgagtgaca atgacatcca     1200

ctttgccttt ctctccacag gtgtccactc ccaggtccaa gtttggtcta gagctagcac     1260

catg                                                                  1264


<210>  14
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  P2 inducible promoter

<400>  14
aataaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgatagtac       60

taacatacgc tctccatcaa aacaaaacga aacaaaacaa actagcaaaa taggctgtcc      120

ccagtgcaag tgcaggtgcc agaacatttc tctatcgata gctagcccag gacagtactc      180

cgacttactt aatattttca ggctagccca ggacagtact ccgacttact taatattttc      240

aggctagccc aggacagtac tccgacttac ttaatatttt caggctagcc caggacagta      300

ctccgactta cttaatattt tcaggctagc ccaggacagt actccgactt acttaatatt      360

ttcaggctag cccaggacag tactccgact tacttaatat tttcaggcta gcccaggaca      420

gtactccgac taacttaata ttttcaggct agcccaggac agtactccga cttactaata      480

ttttcagcta gcggggggct ataaaagggg gtgggggcgt tcgtcctgct atctagcgtc      540

gcgttgacca tg                                                          552


<210>  15
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crTet crRNA spacer

<400>  15
ctccctatca gtgatagaga acg                                               23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crLacZ crRNA spacer

<400>  16
cgaatacgcc cacgcgatgg gt                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crP2 crRNA spacer

<400>  17
aggctagccc aggacagtac tc                                                22


<210>  18
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_1 crRNA spacer

<400>  18
gcaaggatgg acgcgccaca gag                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_2 crRNA spacer

<400>  19
ctaagtttga gggaagcggg atg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_3 crRNA spacer

<400>  20
cgggtggtcg gtagtgagtc cgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_4 crRNA spacer

<400>  21
taaaaacacg ctccgagcgc ggc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_5 crRNA spacer

<400>  22
tataaaagtc cggccgcggc cag                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crCXCR4_10 (cutting)crRNA spacer

<400>  23
ttcacggaaa cagggttcct tca                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_1 crRNA spacer

<400>  24
accagggcga agtggggagg tac                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_2 crRNA spacer

<400>  25
acttcacacc attcaaggac tgg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_3 crRNA spacer

<400>  26
acgatgagac agacccatta tgc                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_4 crRNA spacer

<400>  27
gtggcatttg ggtgttgtag tta                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_5 crRNA spacer

<400>  28
agatgagatg gtgacagata ggc                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIFNg_6 crRNA spacer

<400>  29
tacctaattg aagtctcctg agg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_1 crRNA spacer

<400>  30
gtatccccac ccccttaaag aaa                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_2 crRNA spacer

<400>  31
ttacattagc ccacacttag gtg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_3 crRNA spacer

<400>  32
acctacatcc attcagtcag tct                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_4 crRNA spacer

<400>  33
gacaccccca taatattttt cca                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_5 crRNA spacer

<400>  34
cctcttctga tgactctttg gaa                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_6 crRNA spacer

<400>  35
atacagaagg cgttaattgc atg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_7 crRNA spacer

<400>  36
ctcttgctct tgtccaccac aat                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_8 crRNA spacer

<400>  37
atctgtttac tcttgctctt gtc                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_9 crRNA spacer

<400>  38
tgagttactt ttgtatcccc acc                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_10 crRNA spacer

<400>  39
cctttttatc cacacaatga gct                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_11 crRNA spacer

<400>  40
ttgataaaac aggaagtgta ttg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_12 crRNA spacer

<400>  41
tcataaaact acactgaaca tgt                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_13 crRNA spacer

<400>  42
ggggtttaaa gaaattccaa aga                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  crIL2_14 crRNA spacer

<400>  43
agacaggtaa agtctttgaa aat                                               23


