
                                SEQUENCE LISTING

<110> Michael C. Jensen
      James F. Matthaei
      Joseph K. Cheng

<120> ANTI-DINITROPHENOL CHIMERIC ANTIGEN
  RECEPTORS

<130> SCRI.269WO

<150> 62969931            
<151> 2020-02-04  

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH of anti DNP scFv (Ab-1; 1BAF)

<400> 1
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Gln Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Met Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu
    50                  55                  60                  
Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Trp Pro Leu Ala Tyr Trp Gly Gln Gly Thr Gln Val Ser
            100                 105                 110         
Val Ser Glu Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro
        115                 120                 125             
Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser
145                 150                 155                 160 
Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu
                165                 170                 175     
Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser
            180                 185                 190         
Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val
        195                 200                 205             
Asp Lys Lys Ile Val Pro Arg Asp Cys
    210                 215         


<210> 2
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL of anti DNP scFv (Ab-1; 1BAF)

<400> 2
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Tyr Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Ile
                85                  90                  95      
Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys
    210                 


<210> 3
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH of anti DNP scFv (Ab-2; XC)

<400> 3
Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys
 1               5                  10                  15      
Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu
            20                  25                  30          
Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45              
Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr
    50                  55                  60                  
Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp
65                  70                  75                  80  
Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr
                85                  90                  95      
Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp Val Leu
            100                 105                 110         
Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val
        115                 120                 125 


<210> 4
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL of anti DNP scFv (Ab-2; XC)

<400> 4
Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn
            20                  25                  30          
Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu
65                  70                  75                  80  
Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser
                85                  90                  95      
Gly Asn Leu Asp Ala Leu Ala Phe
            100                 


<210> 5
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH of anti DNP scFv (Ab-3)

<400> 5
Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys
 1               5                  10                  15      
Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu
            20                  25                  30          
Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45              
Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr
    50                  55                  60                  
Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp
65                  70                  75                  80  
Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr
                85                  90                  95      
Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp Val Leu
            100                 105                 110         
Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val
        115                 120                 125 


<210> 6
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL of anti DNP scFv (Ab-3)

<400> 6
Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val
 1               5                  10                  15      
Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu
            20                  25                  30          
Ser Val Tyr Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly
        35                  40                  45              
Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly
    50                  55                  60                  
Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu
65                  70                  75                  80  
Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln
                85                  90                  95      
Gly Gly Tyr Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly
            100                 105                 110         
Thr Glu Val Val Val Arg Gly
        115                 


<210> 7
<211> 263
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-linker-VH of anti DNP scFv (Ab-3)

<400> 7
Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val
 1               5                  10                  15      
Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu
            20                  25                  30          
Ser Val Tyr Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly
        35                  40                  45              
Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly
    50                  55                  60                  
Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu
65                  70                  75                  80  
Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln
                85                  90                  95      
Gly Gly Tyr Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly
            100                 105                 110         
Thr Glu Val Val Val Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gln Cys Gln Gln Leu Glu Gln Ser Gly Gly
    130                 135                 140                 
Gly Ala Glu Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Glu Leu Cys
145                 150                 155                 160 
Cys Lys Ala Ser Gly Phe Ser Leu Ser Ser Ser Tyr Cys Ile Cys Trp
                165                 170                 175     
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr
            180                 185                 190         
Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Val Asn Gly Arg
        195                 200                 205             
Phe Thr Leu Ser Arg Asp Ile Asp Gln Ser Thr Gly Cys Leu Gln Leu
    210                 215                 220                 
Asn Ser Leu Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ala
225                 230                 235                 240 
Pro Tyr Ser Ser Gly Trp Val Leu Tyr Phe Asn Leu Trp Gly Pro Gly
                245                 250                 255     
Thr Leu Val Ile Val Ser Ser
            260             


<210> 8
<211> 263
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (Ab-3)

<400> 8
Gln Cys Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu
 1               5                  10                  15      
Val Lys Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe
            20                  25                  30          
Ser Leu Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly
        35                  40                  45              
Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser
    50                  55                  60                  
Thr Tyr Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp
65                  70                  75                  80  
Ile Asp Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala
                85                  90                  95      
Asp Thr Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp
            100                 105                 110         
Val Leu Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val Ser
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val
145                 150                 155                 160 
Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu
                165                 170                 175     
Ser Val Tyr Gly Asn Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly
            180                 185                 190         
Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly
        195                 200                 205             
Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu
    210                 215                 220                 
Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln
225                 230                 235                 240 
Gly Gly Tyr Tyr Ser Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly
                245                 250                 255     
Thr Glu Val Val Val Arg Gly
            260             


<210> 9
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (1BAF)

<400> 9
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Gln Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Met Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu
    50                  55                  60                  
Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Trp Pro Leu Ala Tyr Trp Gly Gln Gly Thr Gln Val Ser
            100                 105                 110         
Val Ser Glu Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro
        115                 120                 125             
Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val
    130                 135                 140                 
Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser
145                 150                 155                 160 
Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu
                165                 170                 175     
Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Pro Arg Pro Ser
            180                 185                 190         
Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val
        195                 200                 205             
Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Gly Gly Gly Ser Gly Gly
    210                 215                 220                 
Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro
225                 230                 235                 240 
Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser
                245                 250                 255     
Ala Ser Ser Ser Val Tyr Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly
            260                 265                 270         
Ser Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly
        275                 280                 285             
Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
    290                 295                 300                 
Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
305                 310                 315                 320 
Gln Trp Ser Ser Tyr Pro Pro Ile Thr Phe Gly Val Gly Thr Lys Leu
                325                 330                 335     
Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro
            340                 345                 350         
Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu
        355                 360                 365             
Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly
    370                 375                 380                 
Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser
385                 390                 395                 400 
Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp
                405                 410                 415     
Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr
            420                 425                 430         
Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys
        435                 440                 445     


<210> 10
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-linker-VH of anti DNP scFv (1BAF)

<400> 10
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Tyr Tyr Met
            20                  25                  30          
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Ile
                85                  90                  95      
Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser
        195                 200                 205             
Phe Asn Arg Asn Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    210                 215                 220                 
Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
225                 230                 235                 240 
Val Lys Pro Ser Gln Ser Gln Ser Leu Thr Cys Thr Val Thr Gly Tyr
                245                 250                 255     
Ser Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly
            260                 265                 270         
Asn Lys Leu Glu Trp Met Gly Tyr Met Ser Tyr Ser Gly Ser Thr Arg
        275                 280                 285             
Tyr Asn Pro Ser Leu Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
    290                 295                 300                 
Lys Asn Gln Phe Phe Leu Gln Leu Lys Ser Val Thr Thr Glu Asp Thr
305                 310                 315                 320 
Ala Thr Tyr Phe Cys Ala Arg Gly Trp Pro Leu Ala Tyr Trp Gly Gln
                325                 330                 335     
Gly Thr Gln Val Ser Val Ser Glu Ala Lys Thr Thr Pro Pro Ser Val
            340                 345                 350         
Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr
        355                 360                 365             
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr
    370                 375                 380                 
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val
385                 390                 395                 400 
Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser
                405                 410                 415     
Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala
            420                 425                 430         
Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys
        435                 440                 445     


<210> 11
<211> 246
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (XC)

<400> 11
Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val Lys
 1               5                  10                  15      
Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser Leu
            20                  25                  30          
Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly
        35                  40                  45              
Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr
    50                  55                  60                  
Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile Asp
65                  70                  75                  80  
Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp Thr
                85                  90                  95      
Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp Val Leu
            100                 105                 110         
Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val Ser Ser Gly
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln
    130                 135                 140                 
Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly Thr
145                 150                 155                 160 
Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn Ser Arg
                165                 170                 175     
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
            180                 185                 190         
Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly
        195                 200                 205             
Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys
    210                 215                 220                 
Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Gly Asn
225                 230                 235                 240 
Leu Asp Ala Leu Ala Phe
                245     


<210> 12
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL-linker-VH of anti DNP scFv (XC)

<400> 12
Ala Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly
 1               5                  10                  15      
Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Gly Asn
            20                  25                  30          
Ser Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu
65                  70                  75                  80  
Glu Cys Asp Asp Ala Ala Ser Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser
                85                  90                  95      
Gly Asn Leu Asp Ala Leu Ala Phe Gly Gly Gly Thr Glu Val Val Val
            100                 105                 110         
Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Gln Gln Leu Glu Gln Ser Gly Gly Gly Ala Glu Gly Gly Leu Val
    130                 135                 140                 
Lys Pro Gly Gly Ser Leu Glu Leu Cys Cys Lys Ala Ser Gly Phe Ser
145                 150                 155                 160 
Leu Ser Ser Ser Tyr Cys Ile Cys Trp Val Arg Gln Ala Pro Gly Lys
                165                 170                 175     
Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr
            180                 185                 190         
Tyr Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser Arg Asp Ile
        195                 200                 205             
Asp Gln Ser Thr Gly Cys Leu Gln Leu Asn Ser Leu Thr Ala Ala Asp
    210                 215                 220                 
Thr Ala Met Tyr Tyr Cys Ala Arg Ala Pro Tyr Ser Ser Gly Trp Val
225                 230                 235                 240 
Leu Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val Ile Val
                245                 250                 


<210> 13
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (1BAF)

<400> 13
gacgtacaac tgcaagaatc aggtccggga ctggtcaaac ctagccagtc tcagtccttg 60
acgtgcaccg tgacgggcta tagtataacg agtgattacg cttggaattg gattcggcag 120
tttccaggca ataagcttga gtggatgggc tatatgtctt actccggctc aactaggtat 180
aatccgagcc ttcggtctcg gatttctatc acaagagata cgagtaagaa tcagtttttt 240
cttcaactca aaagcgtcac cacggaggat accgccacat atttctgtgc taggggatgg 300
cctcttgctt attgggggca agggacacaa gtgtctgttt ccgaagccaa aacaacgccc 360
ccttcagtct atccgctggc accgggaagc gcggcacaaa ccaatagtat ggtaacgctc 420
ggatgtctcg tcaaggggta ttttcccgag cctgtgacag tgacatggaa ttctgggagt 480
cttagcagcg gagtacatac ttttccggca gtacttcaat ccgatttgta cacgctctcc 540
tctagtgtta cagttccaag ctctccacga cctagtgaga ccgttacatg taacgtcgcg 600
catccggcct cttccactaa agtggataaa aagattgtgc ccagggactg cggcggaggg 660
ggctctggcg gcggaggatc tgggggaggg ggcagccaaa ttgtgttgac ccagtccccg 720
gccataatgt ccgcttctcc tggcgagaag gttactatga cttgctcagc ctcctccagt 780
gtgtattata tgtactggta tcaacaaaag ccgggctctt ccccccggct ccttatatac 840
gacacgagta atctggcaag tggcgtgcct gttagatttt ctgggtccgg ctctggaact 900
tcatactccc tgacaattag ccgaatggaa gccgaggacg cggcgacata ctactgccag 960
caatggtcat cctatccgcc tatcactttt ggagtaggga ccaaattgga gttgaagcgg 1020
gctgatgcgg ctcccacagt tagtattttc cctccgtcca gtgaacaact tacctccggg 1080
ggagcctccg ttgtttgctt tctgaacaac ttttacccga aagatataaa tgtcaagtgg 1140
aagatcgacg gctcagagcg ccaaaacggg gtactcaact catggacaga tcaggatagt 1200
aaagattcaa cttacagtat gtctagtacc ctgacactga cgaaagatga atacgaaaga 1260
cataatagtt atacctgtga agctacacat aagacttcaa cctctcctat tgtaaaatca 1320
ttcaaccgaa acgaatgt                                               1338

<210> 14
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL-linker-VH of anti DNP scFv (1BAF)

<400> 14
caaattgtgt tgacccagtc cccggccata atgtccgctt ctcctggcga gaaggttact 60
atgacttgct cagcctcctc cagtgtgtat tatatgtact ggtatcaaca aaagccgggc 120
tcttcccccc ggctccttat atacgacacg agtaatctgg caagtggcgt gcctgttaga 180
ttttctgggt ccggctctgg aacttcatac tccctgacaa ttagccgaat ggaagccgag 240
gacgcggcga catactactg ccagcaatgg tcatcctatc cgcctatcac ttttggagta 300
gggaccaaat tggagttgaa gcgggctgat gcggctccca cagttagtat tttccctccg 360
tccagtgaac aacttacctc cgggggagcc tccgttgttt gctttctgaa caacttttac 420
ccgaaagata taaatgtcaa gtggaagatc gacggctcag agcgccaaaa cggggtactc 480
aactcatgga cagatcagga tagtaaagat tcaacttaca gtatgtctag taccctgaca 540
ctgacgaaag atgaatacga aagacataat agttatacct gtgaagctac acataagact 600
tcaacctctc ctattgtaaa atcattcaac cgaaacgaat gtggcggagg gggctctggc 660
ggcggaggat ctgggggagg gggcagcgac gtacaactgc aagaatcagg tccgggactg 720
gtcaaaccta gccagtctca gtccttgacg tgcaccgtga cgggctatag tataacgagt 780
gattacgctt ggaattggat tcggcagttt ccaggcaata agcttgagtg gatgggctat 840
atgtcttact ccggctcaac taggtataat ccgagccttc ggtctcggat ttctatcaca 900
agagatacga gtaagaatca gttttttctt caactcaaaa gcgtcaccac ggaggatacc 960
gccacatatt tctgtgctag gggatggcct cttgcttatt gggggcaagg gacacaagtg 1020
tctgtttccg aagccaaaac aacgccccct tcagtctatc cgctggcacc gggaagcgcg 1080
gcacaaacca atagtatggt aacgctcgga tgtctcgtca aggggtattt tcccgagcct 1140
gtgacagtga catggaattc tgggagtctt agcagcggag tacatacttt tccggcagta 1200
cttcaatccg atttgtacac gctctcctct agtgttacag ttccaagctc tccacgacct 1260
agtgagaccg ttacatgtaa cgtcgcgcat ccggcctctt ccactaaagt ggataaaaag 1320
attgtgccca gggactgc                                               1338

<210> 15
<211> 738
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (XC)

<400> 15
cagcagctgg agcagtccgg aggaggagcc gaaggaggcc tggtcaagcc tgggggatcc 60
ctggaactct gctgcaaagc ctctggattc tccctcagta gtagctactg catatgttgg 120
gtccgccagg ctccagggaa ggggctggag tggatcggat gcatttatgc tggtagtagt 180
ggtagcactt actacgcgag ctgggtgaat ggccgattca ctctctccag agacattgac 240
cagagcacag gttgcctaca actgaacagt ctgacagccg cggacacggc catgtattac 300
tgtgcgagag ccccctatag tagtggctgg gtcctctact ttaacttgtg gggcccaggc 360
accctggtca ttgtctcctc aggcggaggg ggctctggcg gcggaggatc tgggggaggg 420
ggcagcgccc aagtgctgac ccagactcca tcgcctgtgt ctgcagctgt gggaggcaca 480
gtcaccatca gttgccagtc cagtgagagt gtttatggta acagccgctt agcctggtat 540
cagcagaaac cagggcagtc tcccaagctc ctgatctatt atgcatccac tctggcatct 600
ggggtccctt cgcggttcaa aggcagtgga tctgggacac agttcactct caccattagc 660
gacctggagt gtgacgatgc tgcctcttac tactgtcaag gcggttatta tagtggtaat 720
cttgatgcgc ttgctttc                                               738

<210> 16
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL-linker-VH of anti DNP scFv (XC)

<400> 16
gcccaagtgc tgacccagac tccatcgcct gtgtctgcag ctgtgggagg cacagtcacc 60
atcagttgcc agtccagtga gagtgtttat ggtaacagcc gcttagcctg gtatcagcag 120
aaaccagggc agtctcccaa gctcctgatc tattatgcat ccactctggc atctggggtc 180
ccttcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat tagcgacctg 240
gagtgtgacg atgctgcctc ttactactgt caaggcggtt attatagtgg taatcttgat 300
gcgcttgctt tcggcggagg gaccgaggtg gtggtcagag gtggcggagg gggctctggc 360
ggcggaggat ctgggggagg gggcagccag cagctggagc agtccggagg aggagccgaa 420
ggaggcctgg tcaagcctgg gggatccctg gaactctgct gcaaagcctc tggattctcc 480
ctcagtagta gctactgcat atgttgggtc cgccaggctc cagggaaggg gctggagtgg 540
atcggatgca tttatgctgg tagtagtggt agcacttact acgcgagctg ggtgaatggc 600
cgattcactc tctccagaga cattgaccag agcacaggtt gcctacaact gaacagtctg 660
acagccgcgg acacggccat gtattactgt gcgagagccc cctatagtag tggctgggtc 720
ctctacttta acttgtgggg cccaggcacc ctggtcattg tc                    762

<210> 17
<211> 788
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH-linker-VL of anti DNP scFv (Ab-3)

<400> 17
ccaggtgcca catttgccca agtgctgacc cagactccat cgcctgtgtc tgcagctgtg 60
ggaggcacag tcaccatcag ttgccagtcc agtgagagtg tttatggtaa cagccgctta 120
gcctggtatc agcagaaacc agggcagtct cccaagctcc tgatctatta tgcatccact 180
ctggcatctg gggtcccttc gcggttcaaa ggcagtggat ctgggacaca gttcactctc 240
accattagcg acctggagtg tgacgatgct gcctcttact actgtcaagg cggttattat 300
agtggtaatc ttgatgcgct tgctttcggc ggagggaccg aggtggtggt cagaggtggc 360
ggagggggct ctggcggcgg aggatctggg ggagggggca gccagtgtca gcagctggag 420
cagtccggag gaggagccga aggaggcctg gtcaagcctg ggggatccct ggaactctgc 480
tgcaaagcct ctggattctc cctcagtagt agctactgca tatgttgggt ccgccaggct 540
ccagggaagg ggctggagtg gatcggatgc atttatgctg gtagtagtgg tagcacttac 600
tacgcgagct gggtgaatgg ccgattcact ctctccagag acattgacca gagcacaggt 660
tgcctacaac tgaacagtct gacagccgcg gacacggcca tgtattactg tgcgagagcc 720
ccctatagta gtggctgggt cctctacttt aacttgtggg gcccaggcac cctggtcatt 780
gtctcctc                                                          788

<210> 18
<211> 789
<212> DNA
<213> Artificial Sequence

<220> 
<223> anti DNP scFv
      VH-linker-VL of anti DNP scFv (Ab-3)
      

<400> 18
cagtgtcagc agctggagca gtccggagga ggagccgaag gaggcctggt caagcctggg 60
ggatccctgg aactctgctg caaagcctct ggattctccc tcagtagtag ctactgcata 120
tgttgggtcc gccaggctcc agggaagggg ctggagtgga tcggatgcat ttatgctggt 180
agtagtggta gcacttacta cgcgagctgg gtgaatggcc gattcactct ctccagagac 240
attgaccaga gcacaggttg cctacaactg aacagtctga cagccgcgga cacggccatg 300
tattactgtg cgagagcccc ctatagtagt ggctgggtcc tctactttaa cttgtggggc 360
ccaggcaccc tggtcattgt ctcctcaggc ggagggggct ctggcggcgg aggatctggg 420
ggagggggca gcccaggtgc cacatttgcc caagtgctga cccagactcc atcgcctgtg 480
tctgcagctg tgggaggcac agtcaccatc agttgccagt ccagtgagag tgtttatggt 540
aacagccgct tagcctggta tcagcagaaa ccagggcagt ctcccaagct cctgatctat 600
tatgcatcca ctctggcatc tggggtccct tcgcggttca aaggcagtgg atctgggaca 660
cagttcactc tcaccattag cgacctggag tgtgacgatg ctgcctctta ctactgtcaa 720
ggcggttatt atagtggtaa tcttgatgcg cttgctttcg gcggagggac cgaggtggtg 780
gtcagaggt                                                         789

<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 20
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> Long spacer: IgG4hinge-CH2(L235D)-CH3

<400> 20
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 


<210> 21
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Medium spacer: IgG4 hinge-CH3

<400> 21
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg
 1               5                  10                  15      
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
            20                  25                  30          
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
        35                  40                  45              
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
    50                  55                  60                  
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
65                  70                  75                  80  
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
                85                  90                  95      
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
            100                 105                 110         
Leu Ser Leu Ser Leu Gly Lys
        115                 


<210> 22
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Short spacer: IgG4 hinge

<400> 22
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 23
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28tm

<400> 23
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
 1               5                  10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25              


<210> 24
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB

<400> 24
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 25
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3 zeta

<400> 25
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 26
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> T2A

<400> 26
Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15      
Glu Asn Pro Gly Pro
            20      


<210> 27
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> GM-CSF receptor ss to EGFRt

<400> 27
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         


<210> 28
<211> 187
<212> PRT
<213> Artificial Sequence

<220> 
<223> DHFRdm

<400> 28
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly
 1               5                  10                  15      
Ile Gly Lys Asn Gly Asp Phe Pro Trp Pro Pro Leu Arg Asn Glu Ser
            20                  25                  30          
Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln
        35                  40                  45              
Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys
    50                  55                  60                  
Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu
65                  70                  75                  80  
Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp
                85                  90                  95      
Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met
            100                 105                 110         
Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His
        115                 120                 125             
Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu
    130                 135                 140                 
Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu
145                 150                 155                 160 
Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile
                165                 170                 175     
Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp
            180                 185         


<210> 29
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> GM-CSF signal Sequence

<400> 29
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro
            20          

