                         SEQUENCE LISTING

<110>  BIORCHESTRA CO., LTD.
 
<120>  USE OF MIRNA-485 INHIBITORS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS (ALS)

<130>  4366.021PC03/C-K/DKC

<150>  US 62/971,771
<151>  2020-02-07

<150>  US 62/989,487
<151>  2020-03-13

<150>  US 63/047,147
<151>  2020-07-01

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  1
gucauacacg gcucuccucu cu                                                22


<210>  2
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  2
uguauga                                                                  7


<210>  3
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  3
guguauga                                                                 8


<210>  4
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  4
cguguauga                                                                9


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  5
ccguguauga                                                              10


<210>  6
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  6
gccguguaug a                                                            11


<210>  7
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  7
agccguguau ga                                                           12


<210>  8
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  8
gagccgugua uga                                                          13


<210>  9
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  9
agagccgugu auga                                                         14


<210>  10
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  10
gagagccgug uauga                                                        15


<210>  11
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  11
ggagagccgu guauga                                                       16


<210>  12
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  12
aggagagccg uguauga                                                      17


<210>  13
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  13
gaggagagcc guguauga                                                     18


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  14
agaggagagc cguguauga                                                    19


<210>  15
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  15
gagaggagag ccguguauga                                                   20


<210>  16
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  16
uguaugac                                                                 8


<210>  17
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  17
guguaugac                                                                9


<210>  18
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  18
cguguaugac                                                              10


<210>  19
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  19
ccguguauga c                                                            11


<210>  20
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  20
gccguguaug ac                                                           12


<210>  21
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  21
agccguguau gac                                                          13


<210>  22
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  22
gagccgugua ugac                                                         14


<210>  23
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  23
agagccgugu augac                                                        15


<210>  24
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  24
gagagccgug uaugac                                                       16


<210>  25
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  25
ggagagccgu guaugac                                                      17


<210>  26
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  26
aggagagccg uguaugac                                                     18


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  27
gaggagagcc guguaugac                                                    19


<210>  28
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  28
agaggagagc cguguaugac                                                   20


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  29
gagaggagag ccguguauga c                                                 21


<210>  30
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  30
agagaggaga gccguguaug ac                                                22


<210>  31
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


<210>  32
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr 
    450                 455                 460                 


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu 
465                 470                 475                 480 


Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser 
                485                 490                 495     


Pro Ser Leu Glu Glu Pro Met Glu Asp Glu Ser Glu Ile Glu Glu Phe 
            500                 505                 510         


Tyr Asn Gly Leu Glu Asp Glu Pro Asp Val Pro Glu Arg Ala Gly Gly 
        515                 520                 525             


Ala Gly Phe Gly Thr Asp Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala 
    530                 535                 540                 


Ile Ser Val Lys Gln Glu Val Thr Asp Met Asn Tyr Pro Ser Asn Lys 
545                 550                 555                 560 


Ser 
    


<210>  33
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  33
agaggcuggc cgugaugaau uc                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-3p

<400>  34
agucauacac ggcucuccuc uc                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-485-5p

<400>  35
agaggcuggc cgugaugaau uc                                                22


<210>  36
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  37
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Glu Thr Cys Val His Phe Thr Ser Ser Phe Ser Val Cys Lys Ser 
        275                 280                 285             


<210>  38
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Ser Ile Tyr Ala Val Phe 
225                 230                 235                 240 


Glu Ser Asp Val Asn Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu 
                245                 250                 255     


Pro Ser Lys Ala Phe Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys 
            260                 265                 270         


Phe Cys Thr Glu Lys Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val 
        275                 280                 285             


Leu Asp Ile Ser Lys Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu 
    290                 295                 300                 


Pro His Phe Leu Tyr Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly 
305                 310                 315                 320 


Leu Asn Pro Asn Glu Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro 
                325                 330                 335     


Ile Thr Gly Phe Thr Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu 
            340                 345                 350         


Leu Val Lys Pro Ser Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg 
        355                 360                 365             


Asn Tyr Ile Val Pro Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly 
    370                 375                 380                 


Asp Glu Lys Ala Asn Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn 
385                 390                 395                 400 


Leu Leu Gly Leu Ile Glu Met Ile Leu Leu Ser Val Gly Val Val Met 
                405                 410                 415     


Phe Val Ala Phe Met Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile 
            420                 425                 430         


Lys 
    


<210>  39
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Tyr 
    130                 135                 140                 


Asn Asn Thr Ala Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn 
145                 150                 155                 160 


Ile Ser Lys Val Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu 
                165                 170                 175     


Ser Tyr Trp Glu Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala 
            180                 185                 190         


Ser Phe Pro Pro Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser 
        195                 200                 205             


Ser Asp Ile Cys Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn 
    210                 215                 220                 


Leu Lys Gly Ile Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe 
225                 230                 235                 240 


Ala Ser Pro Val Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys 
                245                 250                 255     


Ile Ile Ser Lys Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys 
            260                 265                 270         


Cys Lys Glu Gly Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr 
        275                 280                 285             


Ala Ser Pro Asp Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu 
    290                 295                 300                 


Glu Glu His Arg Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr 
305                 310                 315                 320 


Leu Gln Phe Ala Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser 
                325                 330                 335     


Glu Lys Ile Gln Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro 
            340                 345                 350         


Ile Leu Trp Leu Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn 
        355                 360                 365             


Met Phe Arg Ser Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile 
    370                 375                 380                 


Glu Met Ile Leu Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met 
385                 390                 395                 400 


Ile Ser Tyr Cys Ala Cys Arg Ser Lys Thr Ile Lys 
                405                 410         


<210>  40
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  41
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Leu Phe Leu 
            260                 265                 270     


<210>  42
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr 
        275                 280                 285             


Leu Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr 
    290                 295                 300                 


Pro Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys 
305                 310                 315                 320 


Leu Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro 
                325                 330                 335     


Arg Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys 
            340                 345                 350         


Gly Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val 
        355                 360                 365             


Leu Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg 
    370                 375                 380                 


Leu Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu 
385                 390                 395                 400 


Ile Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu 
                405                 410                 415     


Asn Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr 
            420                 425                 430         


Asp Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln 
        435                 440                 445             


Val Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg 
    450                 455                 460                 


Ala Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp 
465                 470                 475                 480 


Asp Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn 
                485                 490                 495     


Glu Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met 
            500                 505                 510         


Asp Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr 
        515                 520                 525             


Pro Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser 
    530                 535                 540                 


Cys Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys 
545                 550                 555                 560 


Ser Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser 
                565                 570                 575     


Phe Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr 
        595                 600                 605             


Glu Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr 
    610                 615                 620                 


Val Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp 
625                 630                 635                 640 


Ser Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg 
                645                 650                 655     


Arg Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg 
            660                 665                 670         


Gln Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys 
        675                 680                 685             


Ile Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val 
    690                 695                 700                 


Phe Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp 
705                 710                 715                 720 


Ser Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala 
                725                 730                 735     


Leu Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu 
            740                 745                 750         


Leu Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp 
        755                 760                 765             


Leu Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys 
    770                 775                 780                 


Tyr Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser 
785                 790                 795                 800 


Leu Arg Arg 
            


<210>  43
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro 
        275                 280                 285             


Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu 
    290                 295                 300                 


Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg 
305                 310                 315                 320 


Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly 
                325                 330                 335     


Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu 
            340                 345                 350         


Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu 
        355                 360                 365             


Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile 
    370                 375                 380                 


Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn 
385                 390                 395                 400 


Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp 
                405                 410                 415     


Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val 
            420                 425                 430         


Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala 
        435                 440                 445             


Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp 
    450                 455                 460                 


Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu 
465                 470                 475                 480 


Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp 
                485                 490                 495     


Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro 
            500                 505                 510         


Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys 
        515                 520                 525             


Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser 
    530                 535                 540                 


Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe 
545                 550                 555                 560 


Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser 
                565                 570                 575     


Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu 
            580                 585                 590         


Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val 
        595                 600                 605             


Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser 
    610                 615                 620                 


Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg 
625                 630                 635                 640 


Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln 
                645                 650                 655     


Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile 
            660                 665                 670         


Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe 
        675                 680                 685             


Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu 
705                 710                 715                 720 


Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu 
                725                 730                 735     


Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu 
            740                 745                 750         


Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr 
        755                 760                 765             


Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu 
    770                 775                 780                 


Arg Arg 
785     


<210>  44
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu 
    130                 135                 140                 


Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His 
145                 150                 155                 160 


Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser 
                165                 170                 175     


Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg 
            180                 185                 190         


Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro 
        195                 200                 205             


Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys 
    210                 215                 220                 


Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln 
225                 230                 235                 240 


Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn 
                245                 250                 255     


Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu 
            260                 265                 270         


Ser Val Glu Leu Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser 
        275                 280                 285             


Lys 
    


<210>  45
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Leu Phe Leu 
        275     


<210>  46
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Asp Glu Gly Tyr Phe Cys Ala Ala Leu Val Gly Glu Asp Gln Pro 
1               5                   10                  15      


Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn 
            20                  25                  30          


Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp 
        35                  40                  45              


Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile 
    50                  55                  60                  


Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu 
65                  70                  75                  80  


Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser 
                85                  90                  95      


Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser 
            100                 105                 110         


Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu 
        115                 120                 125             


Pro Ser Leu Val Arg Thr Leu Pro Thr Val 
    130                 135             


<210>  47
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Val Lys Thr Asn Leu Ile Ser Lys 
    290                 295                 300     


<210>  48
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu 
1               5                   10                  15      


Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn 
            20                  25                  30          


Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg 
        35                  40                  45              


Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn 
    50                  55                  60                  


Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys 
65                  70                  75                  80  


Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr 
                85                  90                  95      


Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys 
            100                 105                 110         


Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro 
        115                 120                 125             


Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys 
    130                 135                 140                 


Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu 
145                 150                 155                 160 


Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys 
                165                 170                 175     


Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser 
            180                 185                 190         


Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu 
        195                 200                 205             


Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln 
    210                 215                 220                 


Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly 
225                 230                 235                 240 


His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp 
                245                 250                 255     


His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn 
            260                 265                 270         


Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val 
        275                 280                 285             


Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln 
    290                 295                 300                 


Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys 
305                 310                 315                 320 


Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn 
                325                 330                 335     


Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp 
            340                 345                 350         


Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser 
        355                 360                 365             


Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe 
    370                 375                 380                 


Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly 
385                 390                 395                 400 


Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe 
                405                 410                 415     


Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser 
            420                 425                 430         


Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His 
        435                 440                 445             


Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro 
    450                 455                 460                 


Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His 
465                 470                 475                 480 


Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg 
                485                 490                 495     


Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu 
            500                 505                 510         


Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu 
        515                 520                 525             


Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys 
    530                 535                 540                 


Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp 
545                 550                 555                 560 


Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile 
                565                 570                 575     


Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe 
            580                 585                 590         


Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly 
        595                 600                 605             


Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys 
    610                 615                 620                 


Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn 
625                 630                 635                 640 


Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu 
                645                 650                 655     


Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
            660                 665                 670     


<210>  49
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  49
ucauaca                                                                  7


<210>  50
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  50
gaggcug                                                                  7


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  51
cgaggtcgac ttcctaga                                                     18


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  52
catacacggc tctcctctct aaa                                               23


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  53
tcctgtggca tccatgaaac                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  54
caatgcctgg gtacatggtg                                                   20


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  55
ccaagtggag gagcagct                                                     18


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  56
gacaaggtac aacccatcgg                                                   20


<210>  57
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  57
ttcgacacat gggataacga gg                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  58
tttttgctgt gagtcccgga g                                                 21


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  59
cagcctagca gcacgtaaat                                                   20


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  60
gaatcgagca ccagttacg                                                    19


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  61
ccttccctga aggttcctcc tt                                                22


<210>  62
<211>  7
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  62
tgtatga                                                                  7


<210>  63
<211>  8
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  63
gtgtatga                                                                 8


<210>  64
<211>  9
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  64
cgtgtatga                                                                9


<210>  65
<211>  10
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  65
ccgtgtatga                                                              10


<210>  66
<211>  11
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  66
gccgtgtatg a                                                            11


<210>  67
<211>  12
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  67
agccgtgtat ga                                                           12


<210>  68
<211>  13
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  68
gagccgtgta tga                                                          13


<210>  69
<211>  14
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  69
agagccgtgt atga                                                         14


<210>  70
<211>  15
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  70
gagagccgtg tatga                                                        15


<210>  71
<211>  16
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  71
ggagagccgt gtatga                                                       16


<210>  72
<211>  17
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  72
aggagagccg tgtatga                                                      17


<210>  73
<211>  18
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  73
gaggagagcc gtgtatga                                                     18


<210>  74
<211>  19
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  74
agaggagagc cgtgtatga                                                    19


<210>  75
<211>  20
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  75
gagaggagag ccgtgtatga                                                   20


<210>  76
<211>  8
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  76
tgtatgac                                                                 8


<210>  77
<211>  9
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  77
gtgtatgac                                                                9


<210>  78
<211>  10
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  78
cgtgtatgac                                                              10


<210>  79
<211>  11
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  79
ccgtgtatga c                                                            11


<210>  80
<211>  12
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  80
gccgtgtatg ac                                                           12


<210>  81
<211>  13
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  81
agccgtgtat gac                                                          13


<210>  82
<211>  14
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  82
gagccgtgta tgac                                                         14


<210>  83
<211>  15
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  83
agagccgtgt atgac                                                        15


<210>  84
<211>  16
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  84
gagagccgtg tatgac                                                       16


<210>  85
<211>  17
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  85
ggagagccgt gtatgac                                                      17


<210>  86
<211>  18
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  86
aggagagccg tgtatgac                                                     18


<210>  87
<211>  19
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  87
gaggagagcc gtgtatgac                                                    19


<210>  88
<211>  20
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  88
agaggagagc cgtgtatgac                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  89
gagaggagag ccgtgtatga c                                                 21


<210>  90
<211>  22
<212>  DNA
<213>  artificial Sequence

<220>
<223>  oligonucleotide

<400>  90
agagaggaga gccgtgtatg ac                                                22


<210>  91
<211>  640
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 1

<400>  91

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210>  92
<211>  648
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 2

<400>  92

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys His Leu Gly Ile Glu Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly 
                245                 250                 255     


Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr 
            260                 265                 270         


Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln 
        275                 280                 285             


Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro 
    290                 295                 300                 


His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr 
305                 310                 315                 320 


Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala 
                325                 330                 335     


Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser 
            340                 345                 350         


Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr 
        355                 360                 365             


Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val 
    370                 375                 380                 


Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu 
385                 390                 395                 400 


Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala 
                405                 410                 415     


Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr 
            420                 425                 430         


Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His 
        435                 440                 445             


Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val 
    450                 455                 460                 


Ser Ser Met Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met 
465                 470                 475                 480 


Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu 
                485                 490                 495     


Lys Lys Phe Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn 
            500                 505                 510         


Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val 
        515                 520                 525             


Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu 
    530                 535                 540                 


Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro 
545                 550                 555                 560 


Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser 
                565                 570                 575     


Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu 
            580                 585                 590         


Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu 
        595                 600                 605             


Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly 
    610                 615                 620                 


Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile 
625                 630                 635                 640 


Ala Asn Gln Asp Pro Ile Ala Val 
                645             


<210>  93
<211>  462
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 3

<400>  93

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg 
            420                 425                 430         


Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr 
        435                 440                 445             


His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 460         


<210>  94
<211>  247
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 4

<400>  94

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Ser Ala Gln Met Ser Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Lys Thr Thr 
                245         


<210>  95
<211>  645
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 6

<400>  95

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210>  96
<211>  637
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 7

<400>  96

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            420                 425                 430         


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        435                 440                 445             


Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    450                 455                 460                 


Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
465                 470                 475                 480 


Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                485                 490                 495     


Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            500                 505                 510         


Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        515                 520                 525             


Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    530                 535                 540                 


Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
545                 550                 555                 560 


Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                565                 570                 575     


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            580                 585                 590         


Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        595                 600                 605             


Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    610                 615                 620                 


Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635         


<210>  97
<211>  241
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 8

<400>  97

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro 
225                 230                 235                 240 


Glu 
    


<210>  98
<211>  422
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 9

<400>  98

Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      


Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          


Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              


Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  


Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  


Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      


Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         


Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             


Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 


Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 


Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     


Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         


Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             


Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 


Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu 
                245                 250                 255     


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
            260                 265                 270         


Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn 
        275                 280                 285             


Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln 
    290                 295                 300                 


Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp 
                325                 330                 335     


Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Ala Thr Ser Thr 
            340                 345                 350         


Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys 
        355                 360                 365             


Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser 
    370                 375                 380                 


Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp 
385                 390                 395                 400 


Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro 
                405                 410                 415     


Phe Leu Ser Leu Pro Glu 
            420         


<210>  99
<211>  296
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 10

<400>  99

Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser 
        275                 280                 285             


Thr Pro Phe Leu Ser Leu Pro Glu 
    290                 295     


<210>  100
<211>  590
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 11

<400>  100

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
        115                 120                 125             


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
    130                 135                 140                 


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
145                 150                 155                 160 


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
                165                 170                 175     


His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
            180                 185                 190         


Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
        195                 200                 205             


Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
    210                 215                 220                 


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
225                 230                 235                 240 


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
                245                 250                 255     


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
            260                 265                 270         


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
        275                 280                 285             


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
    290                 295                 300                 


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
305                 310                 315                 320 


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
                325                 330                 335     


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
            340                 345                 350         


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
        355                 360                 365             


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
    370                 375                 380                 


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
385                 390                 395                 400 


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
                405                 410                 415     


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
            420                 425                 430         


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
        435                 440                 445             


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
    450                 455                 460                 


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
465                 470                 475                 480 


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
                485                 490                 495     


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
            500                 505                 510         


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
        515                 520                 525             


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
    530                 535                 540                 


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
545                 550                 555                 560 


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
                565                 570                 575     


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
            580                 585                 590 


<210>  101
<211>  420
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRG1 Isoform 12

<400>  101

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     


His Ser Glu Arg 
            420 


<210>  102
<211>  179
<212>  PRT
<213>  artificial Sequence

<220>
<223>  STMN2 Isoform 1

<400>  102

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Glu Arg His Ala Ala Glu Val Arg Arg Asn Lys Glu Leu Gln Val Glu 
                165                 170                 175     


Leu Ser Gly 
            


<210>  103
<211>  187
<212>  PRT
<213>  artificial Sequence

<220>
<223>  STMN2 Isoform 2

<400>  103

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Leu Val Lys Phe Ile Ser Ser Glu Leu Lys Glu Ser Ile Glu Ser Gln 
                165                 170                 175     


Phe Leu Glu Leu Gln Arg Glu Gly Glu Lys Gln 
            180                 185         


<210>  104
<211>  1477
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Alpha Isoform 1a

<400>  104

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly His 
    370                 375                 380                 


Ala Met Val Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr 
385                 390                 395                 400 


Thr Gln Glu Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Val 
                405                 410                 415     


Gly Gly Ser Pro Ser Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn 
            420                 425                 430         


Asn Phe Met Gly Cys Leu Lys Glu Val Val Tyr Lys Asn Asn Asp Val 
        435                 440                 445             


Arg Leu Glu Leu Ser Arg Leu Ala Lys Gln Gly Asp Pro Lys Met Lys 
    450                 455                 460                 


Ile His Gly Val Val Ala Phe Lys Cys Glu Asn Val Ala Thr Leu Asp 
465                 470                 475                 480 


Pro Ile Thr Phe Glu Thr Pro Glu Ser Phe Ile Ser Leu Pro Lys Trp 
                485                 490                 495     


Asn Ala Lys Lys Thr Gly Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu 
            500                 505                 510         


Pro Asn Gly Leu Ile Leu Phe Ser His Gly Lys Pro Arg His Gln Lys 
        515                 520                 525             


Asp Ala Lys His Pro Gln Met Ile Lys Val Asp Phe Phe Ala Ile Glu 
    530                 535                 540                 


Met Leu Asp Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr 
545                 550                 555                 560 


Ile Lys Ile Lys Ala Leu Leu Lys Lys Val Asn Asp Gly Glu Trp Tyr 
                565                 570                 575     


His Val Asp Phe Gln Arg Asp Gly Arg Ser Gly Thr Ile Ser Val Asn 
            580                 585                 590         


Thr Leu Arg Thr Pro Tyr Thr Ala Pro Gly Glu Ser Glu Ile Leu Asp 
        595                 600                 605             


Leu Asp Asp Glu Leu Tyr Leu Gly Gly Leu Pro Glu Asn Lys Ala Gly 
    610                 615                 620                 


Leu Val Phe Pro Thr Glu Val Trp Thr Ala Leu Leu Asn Tyr Gly Tyr 
625                 630                 635                 640 


Val Gly Cys Ile Arg Asp Leu Phe Ile Asp Gly Gln Ser Lys Asp Ile 
                645                 650                 655     


Arg Gln Met Ala Glu Val Gln Ser Thr Ala Gly Val Lys Pro Ser Cys 
            660                 665                 670         


Ser Lys Glu Thr Ala Lys Pro Cys Leu Ser Asn Pro Cys Lys Asn Asn 
        675                 680                 685             


Gly Met Cys Arg Asp Gly Trp Asn Arg Tyr Val Cys Asp Cys Ser Gly 
    690                 695                 700                 


Thr Gly Tyr Leu Gly Arg Ser Cys Glu Arg Glu Ala Thr Val Leu Ser 
705                 710                 715                 720 


Tyr Asp Gly Ser Met Phe Met Lys Ile Gln Leu Pro Val Val Met His 
                725                 730                 735     


Thr Glu Ala Glu Asp Val Ser Leu Arg Phe Arg Ser Gln Arg Ala Tyr 
            740                 745                 750         


Gly Ile Leu Met Ala Thr Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg 
        755                 760                 765             


Leu Glu Leu Asp Ala Gly Arg Val Lys Leu Thr Val Asn Leu Asp Cys 
    770                 775                 780                 


Ile Arg Ile Asn Cys Asn Ser Ser Lys Gly Pro Glu Thr Leu Phe Ala 
785                 790                 795                 800 


Gly Tyr Asn Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg 
                805                 810                 815     


Arg Gly Lys Ser Leu Lys Leu Thr Val Asp Asp Gln Gln Ala Met Thr 
            820                 825                 830         


Gly Gln Met Ala Gly Asp His Thr Arg Leu Glu Phe His Asn Ile Glu 
        835                 840                 845             


Thr Gly Ile Ile Thr Glu Arg Arg Tyr Leu Ser Ser Val Pro Ser Asn 
    850                 855                 860                 


Phe Ile Gly His Leu Gln Ser Leu Thr Phe Asn Gly Met Ala Tyr Ile 
865                 870                 875                 880 


Asp Leu Cys Lys Asn Gly Asp Ile Asp Tyr Cys Glu Leu Asn Ala Arg 
                885                 890                 895     


Phe Gly Phe Arg Asn Ile Ile Ala Asp Pro Val Thr Phe Lys Thr Lys 
            900                 905                 910         


Ser Ser Tyr Val Ala Leu Ala Thr Leu Gln Ala Tyr Thr Ser Met His 
        915                 920                 925             


Leu Phe Phe Gln Phe Lys Thr Thr Ser Leu Asp Gly Leu Ile Leu Tyr 
    930                 935                 940                 


Asn Ser Gly Asp Gly Asn Asp Phe Ile Val Val Glu Leu Val Lys Gly 
945                 950                 955                 960 


Tyr Leu His Tyr Val Phe Asp Leu Gly Asn Gly Ala Asn Leu Ile Lys 
                965                 970                 975     


Gly Ser Ser Asn Lys Pro Leu Asn Asp Asn Gln Trp His Asn Val Met 
            980                 985                 990         


Ile Ser Arg Asp Thr Ser Asn Leu  His Thr Val Lys Ile  Asp Thr Lys 
        995                 1000                 1005             


Ile Thr  Thr Gln Ile Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys 
    1010                 1015                 1020             


Ser Asp  Leu Tyr Ile Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser 
    1025                 1030                 1035             


Leu Pro  Lys Leu Val His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu 
    1040                 1045                 1050             


Ala Ser  Val Asp Leu Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp 
    1055                 1060                 1065             


Ala Leu  Phe Cys Asn Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro 
    1070                 1075                 1080             


Ser Thr  Thr Cys Gln Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys 
    1085                 1090                 1095             


Leu Gln  Gln Trp Asp Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser 
    1100                 1105                 1110             


Phe Ser  Gly Pro Leu Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe 
    1115                 1120                 1125             


Ser Lys  Gly Gly Gly Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp 
    1130                 1135                 1140             


Arg Pro  Ser Thr Arg Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr 
    1145                 1150                 1155             


Val Gln  Lys Glu Ala Val Leu  Val Arg Val Asp Ser  Ser Ser Gly 
    1160                 1165                 1170             


Leu Gly  Asp Tyr Leu Glu Leu  His Ile His Gln Gly  Lys Ile Gly 
    1175                 1180                 1185             


Val Lys  Phe Asn Val Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser 
    1190                 1195                 1200             


Asn Ala  Ile Ile Asn Asp Gly  Lys Tyr His Val Val  Arg Phe Thr 
    1205                 1210                 1215             


Arg Ser  Gly Gly Asn Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val 
    1220                 1225                 1230             


Ile Glu  Arg Tyr Pro Ala Gly  Arg Gln Leu Thr Ile  Phe Asn Ser 
    1235                 1240                 1245             


Gln Ala  Thr Ile Ile Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe 
    1250                 1255                 1260             


Gln Gly  Gln Leu Ser Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu 
    1265                 1270                 1275             


Asn Met  Ala Ala Glu Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn 
    1280                 1285                 1290             


Val Arg  Leu Val Gly Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser 
    1295                 1300                 1305             


Thr Ala  Thr Ala Met Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu 
    1310                 1315                 1320             


Thr Thr  Thr Thr Leu Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro 
    1325                 1330                 1335             


Pro Thr  Lys Glu Pro Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val 
    1340                 1345                 1350             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys 
    1355                 1360                 1365             


Glu Pro  Ser Ser Gly Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly 
    1370                 1375                 1380             


Arg Glu  Pro Tyr Pro Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser 
    1385                 1390                 1395             


Ser Thr  Thr Gly Met Val Val  Gly Ile Val Ala Ala  Ala Ala Leu 
    1400                 1405                 1410             


Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg 
    1415                 1420                 1425             


Asp Glu  Gly Ser Tyr His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser 
    1430                 1435                 1440             


Asn Ser  Ala Gln Ser Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro 
    1445                 1450                 1455             


Ser Ser  Ala Lys Ser Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys 
    1460                 1465                 1470             


Glu Tyr  Tyr Val 
    1475         


<210>  105
<211>  1496
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Alpha Isoform 2a

<400>  105

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly Asp 
            260                 265                 270         


Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys Gly 
        275                 280                 285             


Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser Ser 
    290                 295                 300                 


Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly Leu 
305                 310                 315                 320 


Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu Lys 
                325                 330                 335     


Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe Glu 
            340                 345                 350         


Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp His 
        355                 360                 365             


Asp Val Lys Val Thr Arg Asn Leu Arg Gln Val Thr Ile Ser Val Asp 
    370                 375                 380                 


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
385                 390                 395                 400 


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
                405                 410                 415     


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
            420                 425                 430         


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
        435                 440                 445             


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
    450                 455                 460                 


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
465                 470                 475                 480 


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
                485                 490                 495     


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
            500                 505                 510         


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
        515                 520                 525             


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
    530                 535                 540                 


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
545                 550                 555                 560 


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
                565                 570                 575     


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
            580                 585                 590         


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
        595                 600                 605             


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
    610                 615                 620                 


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
625                 630                 635                 640 


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
                645                 650                 655     


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
            660                 665                 670         


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
        675                 680                 685             


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
    690                 695                 700                 


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
705                 710                 715                 720 


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
                725                 730                 735     


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
            740                 745                 750         


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
        755                 760                 765             


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
    770                 775                 780                 


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
785                 790                 795                 800 


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
                805                 810                 815     


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
            820                 825                 830         


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
        835                 840                 845             


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
    850                 855                 860                 


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
865                 870                 875                 880 


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
                885                 890                 895     


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
            900                 905                 910         


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
        915                 920                 925             


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
    930                 935                 940                 


Ile Val Val Glu Leu Val Lys Gly Tyr Leu His Tyr Val Phe Asp Leu 
945                 950                 955                 960 


Gly Asn Gly Ala Asn Leu Ile Lys Gly Ser Ser Asn Lys Pro Leu Asn 
                965                 970                 975     


Asp Asn Gln Trp His Asn Val Met Ile Ser Arg Asp Thr Ser Asn Leu 
            980                 985                 990         


His Thr Val Lys Ile Asp Thr Lys  Ile Thr Thr Gln Ile  Thr Ala Gly 
        995                 1000                 1005             


Ala Arg  Asn Leu Asp Leu Lys  Ser Asp Leu Tyr Ile  Gly Gly Val 
    1010                 1015                 1020             


Ala Lys  Glu Thr Tyr Lys Ser  Leu Pro Lys Leu Val  His Ala Lys 
    1025                 1030                 1035             


Glu Gly  Phe Gln Gly Cys Leu  Ala Ser Val Asp Leu  Asn Gly Arg 
    1040                 1045                 1050             


Leu Pro  Asp Leu Ile Ser Asp  Ala Leu Phe Cys Asn  Gly Gln Ile 
    1055                 1060                 1065             


Glu Arg  Gly Cys Glu Gly Pro  Ser Thr Thr Cys Gln  Glu Asp Ser 
    1070                 1075                 1080             


Cys Ser  Asn Gln Gly Val Cys  Leu Gln Gln Trp Asp  Gly Phe Ser 
    1085                 1090                 1095             


Cys Asp  Cys Ser Met Thr Ser  Phe Ser Gly Pro Leu  Cys Asn Asp 
    1100                 1105                 1110             


Pro Gly  Thr Thr Tyr Ile Phe  Ser Lys Gly Gly Gly  Gln Ile Thr 
    1115                 1120                 1125             


Tyr Lys  Trp Pro Pro Asn Asp  Arg Pro Ser Thr Arg  Ala Asp Arg 
    1130                 1135                 1140             


Leu Ala  Ile Gly Phe Ser Thr  Val Gln Lys Glu Ala  Val Leu Val 
    1145                 1150                 1155             


Arg Val  Asp Ser Ser Ser Gly  Leu Gly Asp Tyr Leu  Glu Leu His 
    1160                 1165                 1170             


Ile His  Gln Gly Lys Ile Gly  Val Lys Phe Asn Val  Gly Thr Asp 
    1175                 1180                 1185             


Asp Ile  Ala Ile Glu Glu Ser  Asn Ala Ile Ile Asn  Asp Gly Lys 
    1190                 1195                 1200             


Tyr His  Val Val Arg Phe Thr  Arg Ser Gly Gly Asn  Ala Thr Leu 
    1205                 1210                 1215             


Gln Val  Asp Ser Trp Pro Val  Ile Glu Arg Tyr Pro  Ala Gly Asn 
    1220                 1225                 1230             


Asn Asp  Asn Glu Arg Leu Ala  Ile Ala Arg Gln Arg  Ile Pro Tyr 
    1235                 1240                 1245             


Arg Leu  Gly Arg Val Val Asp  Glu Trp Leu Leu Asp  Lys Gly Arg 
    1250                 1255                 1260             


Gln Leu  Thr Ile Phe Asn Ser  Gln Ala Thr Ile Ile  Ile Gly Gly 
    1265                 1270                 1275             


Lys Glu  Gln Gly Gln Pro Phe  Gln Gly Gln Leu Ser  Gly Leu Tyr 
    1280                 1285                 1290             


Tyr Asn  Gly Leu Lys Val Leu  Asn Met Ala Ala Glu  Asn Asp Ala 
    1295                 1300                 1305             


Asn Ile  Ala Ile Val Gly Asn  Val Arg Leu Val Gly  Glu Val Pro 
    1310                 1315                 1320             


Ser Ser  Met Thr Thr Glu Ser  Thr Ala Thr Ala Met  Gln Ser Glu 
    1325                 1330                 1335             


Met Ser  Thr Ser Ile Met Glu  Thr Thr Thr Thr Leu  Ala Thr Ser 
    1340                 1345                 1350             


Thr Ala  Arg Arg Gly Lys Pro  Pro Thr Lys Glu Pro  Ile Ser Gln 
    1355                 1360                 1365             


Thr Thr  Asp Asp Ile Leu Val  Ala Ser Ala Glu Cys  Pro Ser Asp 
    1370                 1375                 1380             


Asp Glu  Asp Ile Asp Pro Cys  Glu Pro Ser Ser Ala  Asn Pro Thr 
    1385                 1390                 1395             


Arg Ala  Gly Gly Arg Glu Pro  Tyr Pro Gly Ser Ala  Glu Val Ile 
    1400                 1405                 1410             


Arg Glu  Ser Ser Ser Thr Thr  Gly Met Val Val Gly  Ile Val Ala 
    1415                 1420                 1425             


Ala Ala  Ala Leu Cys Ile Leu  Ile Leu Leu Tyr Ala  Met Tyr Lys 
    1430                 1435                 1440             


Tyr Arg  Asn Arg Asp Glu Gly  Ser Tyr His Val Asp  Glu Ser Arg 
    1445                 1450                 1455             


Asn Tyr  Ile Ser Asn Ser Ala  Gln Ser Asn Gly Ala  Val Val Lys 
    1460                 1465                 1470             


Glu Lys  Gln Pro Ser Ser Ala  Lys Ser Ser Asn Lys  Asn Lys Lys 
    1475                 1480                 1485             


Asn Lys  Asp Lys Glu Tyr Tyr  Val 
    1490                 1495     


<210>  106
<211>  1547
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Alpha Isoform 3a

<400>  106

Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu Leu His 
            260                 265                 270         


Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys Pro Leu 
        275                 280                 285             


Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly 
    290                 295                 300                 


Asp Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys 
305                 310                 315                 320 


Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser 
                325                 330                 335     


Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly 
            340                 345                 350         


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu 
        355                 360                 365             


Lys Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
    370                 375                 380                 


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
385                 390                 395                 400 


His Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly 
                405                 410                 415     


His Ala Met Val Asn Lys Leu His Cys Ser Val Thr Ile Ser Val Asp 
            420                 425                 430         


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
        435                 440                 445             


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
    450                 455                 460                 


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
465                 470                 475                 480 


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
                485                 490                 495     


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
            500                 505                 510         


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
        515                 520                 525             


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
    530                 535                 540                 


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
545                 550                 555                 560 


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
                565                 570                 575     


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
            580                 585                 590         


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
        595                 600                 605             


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
    610                 615                 620                 


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
625                 630                 635                 640 


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
                645                 650                 655     


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
            660                 665                 670         


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
        675                 680                 685             


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
    690                 695                 700                 


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
705                 710                 715                 720 


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
                725                 730                 735     


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
            740                 745                 750         


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
        755                 760                 765             


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
    770                 775                 780                 


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
785                 790                 795                 800 


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
                805                 810                 815     


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
            820                 825                 830         


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
        835                 840                 845             


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
    850                 855                 860                 


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
865                 870                 875                 880 


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
                885                 890                 895     


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
            900                 905                 910         


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
        915                 920                 925             


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
    930                 935                 940                 


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
945                 950                 955                 960 


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
                965                 970                 975     


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
            980                 985                 990         


Ile Val Val Glu Leu Val Lys Gly  Tyr Leu His Tyr Val  Phe Asp Leu 
        995                 1000                 1005             


Gly Asn  Gly Ala Asn Leu Ile  Lys Gly Ser Ser Asn  Lys Pro Leu 
    1010                 1015                 1020             


Asn Asp  Asn Gln Trp His Asn  Val Met Ile Ser Arg  Asp Thr Ser 
    1025                 1030                 1035             


Asn Leu  His Thr Val Lys Ile  Asp Thr Lys Ile Thr  Thr Gln Ile 
    1040                 1045                 1050             


Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys Ser Asp  Leu Tyr Ile 
    1055                 1060                 1065             


Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser Leu Pro  Lys Leu Val 
    1070                 1075                 1080             


His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu Ala Ser  Val Asp Leu 
    1085                 1090                 1095             


Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp Ala Leu  Phe Cys Asn 
    1100                 1105                 1110             


Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro Ser Thr  Thr Cys Gln 
    1115                 1120                 1125             


Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys Leu Gln  Gln Trp Asp 
    1130                 1135                 1140             


Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser Phe Ser  Gly Pro Leu 
    1145                 1150                 1155             


Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe Ser Lys  Gly Gly Gly 
    1160                 1165                 1170             


Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp Arg Pro  Ser Thr Arg 
    1175                 1180                 1185             


Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr Val Gln  Lys Glu Ala 
    1190                 1195                 1200             


Val Leu  Val Arg Val Asp Ser  Ser Ser Gly Leu Gly  Asp Tyr Leu 
    1205                 1210                 1215             


Glu Leu  His Ile His Gln Gly  Lys Ile Gly Val Lys  Phe Asn Val 
    1220                 1225                 1230             


Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser Asn Ala  Ile Ile Asn 
    1235                 1240                 1245             


Asp Gly  Lys Tyr His Val Val  Arg Phe Thr Arg Ser  Gly Gly Asn 
    1250                 1255                 1260             


Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val Ile Glu  Arg Tyr Pro 
    1265                 1270                 1275             


Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala Ile Ala  Arg Gln Arg 
    1280                 1285                 1290             


Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp Glu Trp  Leu Leu Asp 
    1295                 1300                 1305             


Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser Gln Ala  Thr Ile Ile 
    1310                 1315                 1320             


Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe Gln Gly  Gln Leu Ser 
    1325                 1330                 1335             


Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu Asn Met  Ala Ala Glu 
    1340                 1345                 1350             


Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn Val Arg  Leu Val Gly 
    1355                 1360                 1365             


Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser Thr Ala  Thr Ala Met 
    1370                 1375                 1380             


Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu Thr Thr  Thr Thr Leu 
    1385                 1390                 1395             


Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro Pro Thr  Lys Glu Pro 
    1400                 1405                 1410             


Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val Ala Ser  Ala Glu Cys 
    1415                 1420                 1425             


Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys Glu Pro  Ser Ser Gly 
    1430                 1435                 1440             


Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly Arg Glu  Pro Tyr Pro 
    1445                 1450                 1455             


Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1460                 1465                 1470             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1475                 1480                 1485             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1490                 1495                 1500             


His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1505                 1510                 1515             


Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro Ser Ser  Ala Lys Ser 
    1520                 1525                 1530             


Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1535                 1540                 1545         


<210>  107
<211>  139
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Alpha Isoform 4a

<400>  107

Met Asp Met Arg Trp His Cys Glu Asn Ser Gln Thr Thr Asp Asp Ile 
1               5                   10                  15      


Leu Val Ala Ser Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro 
            20                  25                  30          


Cys Glu Pro Ser Ser Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro 
        35                  40                  45              


Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly 
    50                  55                  60                  


Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu 
65                  70                  75                  80  


Leu Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His 
                85                  90                  95      


Val Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly 
            100                 105                 110         


Ala Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys 
        115                 120                 125             


Asn Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
    130                 135                 


<210>  108
<211>  472
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Beta Isoform 1b

<400>  108

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Asn Asn Asp 
        195                 200                 205             


Asn Glu Arg Leu Ala Ile Ala Arg Gln Arg Ile Pro Tyr Arg Leu Gly 
    210                 215                 220                 


Arg Val Val Asp Glu Trp Leu Leu Asp Lys Gly Arg Gln Leu Thr Ile 
225                 230                 235                 240 


Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln Gly Gln 
                245                 250                 255     


Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu Lys Val 
            260                 265                 270         


Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val Gly Asn 
        275                 280                 285             


Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu Ser Thr 
    290                 295                 300                 


Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu Thr Thr 
305                 310                 315                 320 


Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro Thr Lys 
                325                 330                 335     


Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser Ala Glu 
            340                 345                 350         


Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser Ser Gly 
        355                 360                 365             


Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr Pro Gly 
    370                 375                 380                 


Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val 
385                 390                 395                 400 


Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu Tyr Ala 
                405                 410                 415     


Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val Asp Glu 
            420                 425                 430         


Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala Val Val 
        435                 440                 445             


Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn Lys Lys 
    450                 455                 460                 


Asn Lys Asp Lys Glu Tyr Tyr Val 
465                 470         


<210>  109
<211>  442
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NRXN1-Beta Isoform 3b

<400>  109

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Gly Arg Leu Ala 
            20                  25                  30          


Leu Leu Trp Ile Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala 
        35                  40                  45              


Trp Gly Ala Ser Ser Leu Gly Ala His His Ile His His Phe His Gly 
    50                  55                  60                  


Ser Ser Lys His His Ser Val Pro Ile Ala Ile Tyr Arg Ser Pro Ala 
65                  70                  75                  80  


Ser Leu Arg Gly Gly His Ala Gly Thr Thr Tyr Ile Phe Ser Lys Gly 
                85                  90                  95      


Gly Gly Gln Ile Thr Tyr Lys Trp Pro Pro Asn Asp Arg Pro Ser Thr 
            100                 105                 110         


Arg Ala Asp Arg Leu Ala Ile Gly Phe Ser Thr Val Gln Lys Glu Ala 
        115                 120                 125             


Val Leu Val Arg Val Asp Ser Ser Ser Gly Leu Gly Asp Tyr Leu Glu 
    130                 135                 140                 


Leu His Ile His Gln Gly Lys Ile Gly Val Lys Phe Asn Val Gly Thr 
145                 150                 155                 160 


Asp Asp Ile Ala Ile Glu Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys 
                165                 170                 175     


Tyr His Val Val Arg Phe Thr Arg Ser Gly Gly Asn Ala Thr Leu Gln 
            180                 185                 190         


Val Asp Ser Trp Pro Val Ile Glu Arg Tyr Pro Ala Gly Arg Gln Leu 
        195                 200                 205             


Thr Ile Phe Asn Ser Gln Ala Thr Ile Ile Ile Gly Gly Lys Glu Gln 
    210                 215                 220                 


Gly Gln Pro Phe Gln Gly Gln Leu Ser Gly Leu Tyr Tyr Asn Gly Leu 
225                 230                 235                 240 


Lys Val Leu Asn Met Ala Ala Glu Asn Asp Ala Asn Ile Ala Ile Val 
                245                 250                 255     


Gly Asn Val Arg Leu Val Gly Glu Val Pro Ser Ser Met Thr Thr Glu 
            260                 265                 270         


Ser Thr Ala Thr Ala Met Gln Ser Glu Met Ser Thr Ser Ile Met Glu 
        275                 280                 285             


Thr Thr Thr Thr Leu Ala Thr Ser Thr Ala Arg Arg Gly Lys Pro Pro 
    290                 295                 300                 


Thr Lys Glu Pro Ile Ser Gln Thr Thr Asp Asp Ile Leu Val Ala Ser 
305                 310                 315                 320 


Ala Glu Cys Pro Ser Asp Asp Glu Asp Ile Asp Pro Cys Glu Pro Ser 
                325                 330                 335     


Ser Gly Gly Leu Ala Asn Pro Thr Arg Ala Gly Gly Arg Glu Pro Tyr 
            340                 345                 350         


Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met 
        355                 360                 365             


Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile Leu Ile Leu Leu 
    370                 375                 380                 


Tyr Ala Met Tyr Lys Tyr Arg Asn Arg Asp Glu Gly Ser Tyr His Val 
385                 390                 395                 400 


Asp Glu Ser Arg Asn Tyr Ile Ser Asn Ser Ala Gln Ser Asn Gly Ala 
                405                 410                 415     


Val Val Lys Glu Lys Gln Pro Ser Ser Ala Lys Ser Ser Asn Lys Asn 
            420                 425                 430         


Lys Lys Asn Lys Asp Lys Glu Tyr Tyr Val 
        435                 440         


<210>  110
<211>  2527
<212>  PRT
<213>  artificial Sequence

<220>
<223>  LRKK2 Protein

<400>  110

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu Arg Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  111
<211>  873
<212>  PRT
<213>  artificial Sequence

<220>
<223>  VLDLR isoform long

<400>  111

Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Ser Thr 
            740                 745                 750         


Ala Thr Thr Val Thr Tyr Ser Glu Thr Lys Asp Thr Asn Thr Thr Glu 
        755                 760                 765             


Ile Ser Ala Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210>  112
<211>  845
<212>  PRT
<213>  artificial Sequence

<220>
<223>  VLDLR isoform short

<400>  112

Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Arg Ile 
            740                 745                 750         


Asn Val Thr Thr Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr 
        755                 760                 765             


Ser Ala Ala Trp Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala 
    770                 775                 780                 


Val Gly Gly Tyr Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys 
785                 790                 795                 800 


Ser Met Asn Phe Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp 
                805                 810                 815     


Leu Ser Ile Asp Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr 
            820                 825                 830         


Pro Ala Ile Ser Val Val Ser Thr Asp Asp Asp Leu Ala 
        835                 840                 845 


<210>  113
<211>  902
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GRIA4 isoform 1

<400>  113

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Glu Ser Pro Tyr Val Met Tyr Lys Lys 
            420                 425                 430         


Asn His Glu Met Phe Glu Gly Asn Asp Lys Tyr Glu Gly Tyr Cys Val 
        435                 440                 445             


Asp Leu Ala Ser Glu Ile Ala Lys His Ile Gly Ile Lys Tyr Lys Ile 
    450                 455                 460                 


Ala Ile Val Pro Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys 
465                 470                 475                 480 


Ile Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Glu Ile 
                485                 490                 495     


Ala Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp 
            500                 505                 510         


Phe Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys 
        515                 520                 525             


Pro Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala 
    530                 535                 540                 


Tyr Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val 
545                 550                 555                 560 


Val Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu 
                565                 570                 575     


Glu Pro Glu Asp Gly Lys Glu Gly Pro Ser Asp Gln Pro Pro Asn Glu 
            580                 585                 590         


Phe Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Gln 
        595                 600                 605             


Gln Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly 
    610                 615                 620                 


Gly Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala 
625                 630                 635                 640 


Asn Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu 
                645                 650                 655     


Ser Ala Glu Asp Leu Ala Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu 
            660                 665                 670         


Asp Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val 
        675                 680                 685             


Tyr Glu Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe 
    690                 695                 700                 


Thr Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly 
705                 710                 715                 720 


Lys Phe Ala Phe Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln 
                725                 730                 735     


Arg Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys 
            740                 745                 750         


Gly Tyr Gly Val Ala Thr Pro Lys Gly Ser Ser Leu Arg Thr Pro Val 
        755                 760                 765             


Asn Leu Ala Val Leu Lys Leu Ser Glu Ala Gly Val Leu Asp Lys Leu 
    770                 775                 780                 


Lys Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Pro Lys Asp Ser 
785                 790                 795                 800 


Gly Ser Lys Asp Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly 
                805                 810                 815     


Val Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala 
            820                 825                 830         


Leu Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys 
        835                 840                 845             


Leu Thr Phe Ser Glu Ala Ile Arg Asn Lys Ala Arg Leu Ser Ile Thr 
    850                 855                 860                 


Gly Ser Val Gly Glu Asn Gly Arg Val Leu Thr Pro Asp Cys Pro Lys 
865                 870                 875                 880 


Ala Val His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val 
                885                 890                 895     


Ile Ala Ser Asp Leu Pro 
            900         


<210>  114
<211>  433
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GRIA4 isoform 2

<400>  114

Met Arg Ile Ile Ser Arg Gln Ile Val Leu Leu Phe Ser Gly Phe Trp 
1               5                   10                  15      


Gly Leu Ala Met Gly Ala Phe Pro Ser Ser Val Gln Ile Gly Gly Leu 
            20                  25                  30          


Phe Ile Arg Asn Thr Asp Gln Glu Tyr Thr Ala Phe Arg Leu Ala Ile 
        35                  40                  45              


Phe Leu His Asn Thr Ser Pro Asn Ala Ser Glu Ala Pro Phe Asn Leu 
    50                  55                  60                  


Val Pro His Val Asp Asn Ile Glu Thr Ala Asn Ser Phe Ala Val Thr 
65                  70                  75                  80  


Asn Ala Phe Cys Ser Gln Tyr Ser Arg Gly Val Phe Ala Ile Phe Gly 
                85                  90                  95      


Leu Tyr Asp Lys Arg Ser Val His Thr Leu Thr Ser Phe Cys Ser Ala 
            100                 105                 110         


Leu His Ile Ser Leu Ile Thr Pro Ser Phe Pro Thr Glu Gly Glu Ser 
        115                 120                 125             


Gln Phe Val Leu Gln Leu Arg Pro Ser Leu Arg Gly Ala Leu Leu Ser 
    130                 135                 140                 


Leu Leu Asp His Tyr Glu Trp Asn Cys Phe Val Phe Leu Tyr Asp Thr 
145                 150                 155                 160 


Asp Arg Gly Tyr Ser Ile Leu Gln Ala Ile Met Glu Lys Ala Gly Gln 
                165                 170                 175     


Asn Gly Trp His Val Ser Ala Ile Cys Val Glu Asn Phe Asn Asp Val 
            180                 185                 190         


Ser Tyr Arg Gln Leu Leu Glu Glu Leu Asp Arg Arg Gln Glu Lys Lys 
        195                 200                 205             


Phe Val Ile Asp Cys Glu Ile Glu Arg Leu Gln Asn Ile Leu Glu Gln 
    210                 215                 220                 


Ile Val Ser Val Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala 
225                 230                 235                 240 


Asn Leu Gly Phe Lys Asp Ile Ser Leu Glu Arg Phe Ile His Gly Gly 
                245                 250                 255     


Ala Asn Val Thr Gly Phe Gln Leu Val Asp Phe Asn Thr Pro Met Val 
            260                 265                 270         


Ile Lys Leu Met Asp Arg Trp Lys Lys Leu Asp Gln Arg Glu Tyr Pro 
        275                 280                 285             


Gly Ser Glu Thr Pro Pro Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Gly 
    290                 295                 300                 


Val Leu Val Met Ala Glu Thr Phe Arg Ser Leu Arg Arg Gln Lys Ile 
305                 310                 315                 320 


Asp Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala 
                325                 330                 335     


Ala Pro Trp Gly Gln Gly Ile Asp Met Glu Arg Thr Leu Lys Gln Val 
            340                 345                 350         


Arg Ile Gln Gly Leu Thr Gly Asn Val Gln Phe Asp His Tyr Gly Arg 
        355                 360                 365             


Arg Val Asn Tyr Thr Met Asp Val Phe Glu Leu Lys Ser Thr Gly Pro 
    370                 375                 380                 


Arg Lys Val Gly Tyr Trp Asn Asp Met Asp Lys Leu Val Leu Ile Gln 
385                 390                 395                 400 


Asp Val Pro Thr Leu Gly Asn Asp Thr Ala Ala Ile Glu Asn Arg Thr 
                405                 410                 415     


Val Val Val Thr Thr Ile Met Pro Leu Met Lys Asn Pro Ile Leu Arg 
            420                 425                 430         


Asn 
    


<210>  115
<211>  271
<212>  PRT
<213>  artificial Sequence

<220>
<223>  NXPH1

<400>  115

Met Gln Ala Ala Cys Trp Tyr Val Leu Phe Leu Leu Gln Pro Thr Val 
1               5                   10                  15      


Tyr Leu Val Thr Cys Ala Asn Leu Thr Asn Gly Gly Lys Ser Glu Leu 
            20                  25                  30          


Leu Lys Ser Gly Ser Ser Lys Ser Thr Leu Lys His Ile Trp Thr Glu 
        35                  40                  45              


Ser Ser Lys Asp Leu Ser Ile Ser Arg Leu Leu Ser Gln Thr Phe Arg 
    50                  55                  60                  


Gly Lys Glu Asn Asp Thr Asp Leu Asp Leu Arg Tyr Asp Thr Pro Glu 
65                  70                  75                  80  


Pro Tyr Ser Glu Gln Asp Leu Trp Asp Trp Leu Arg Asn Ser Thr Asp 
                85                  90                  95      


Leu Gln Glu Pro Arg Pro Arg Ala Lys Arg Arg Pro Ile Val Lys Thr 
            100                 105                 110         


Gly Lys Phe Lys Lys Met Phe Gly Trp Gly Asp Phe His Ser Asn Ile 
        115                 120                 125             


Lys Thr Val Lys Leu Asn Leu Leu Ile Thr Gly Lys Ile Val Asp His 
    130                 135                 140                 


Gly Asn Gly Thr Phe Ser Val Tyr Phe Arg His Asn Ser Thr Gly Gln 
145                 150                 155                 160 


Gly Asn Val Ser Val Ser Leu Val Pro Pro Thr Lys Ile Val Glu Phe 
                165                 170                 175     


Asp Leu Ala Gln Gln Thr Val Ile Asp Ala Lys Asp Ser Lys Ser Phe 
            180                 185                 190         


Asn Cys Arg Ile Glu Tyr Glu Lys Val Asp Lys Ala Thr Lys Asn Thr 
        195                 200                 205             


Leu Cys Asn Tyr Asp Pro Ser Lys Thr Cys Tyr Gln Glu Gln Thr Gln 
    210                 215                 220                 


Ser His Val Ser Trp Leu Cys Ser Lys Pro Phe Lys Val Ile Cys Ile 
225                 230                 235                 240 


Tyr Ile Ser Phe Tyr Ser Thr Asp Tyr Lys Leu Val Gln Lys Val Cys 
                245                 250                 255     


Pro Asp Tyr Asn Tyr His Ser Asp Thr Pro Tyr Phe Pro Ser Gly 
            260                 265                 270     


<210>  116
<211>  724
<212>  PRT
<213>  artificial Sequence

<220>
<223>  PSD-95 isoform 1

<400>  116

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Glu Leu Gln Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu 
    50                  55                  60                  


Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 
65                  70                  75                  80  


Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 
                85                  90                  95      


Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 
            100                 105                 110         


Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 
        115                 120                 125             


Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val 
    130                 135                 140                 


Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu 
145                 150                 155                 160 


Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly 
                165                 170                 175     


Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr 
            180                 185                 190         


Lys Ile Ile Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile 
        195                 200                 205             


Gly Asp Lys Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 
    210                 215                 220                 


His Glu Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 
225                 230                 235                 240 


Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala 
                245                 250                 255     


Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile 
            260                 265                 270         


Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro 
        275                 280                 285             


Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu 
    290                 295                 300                 


Glu Asp Ile Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser 
305                 310                 315                 320 


Thr Gly Leu Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 
                325                 330                 335     


Phe Ile Ser Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 
            340                 345                 350         


Leu Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 
        355                 360                 365             


Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln 
    370                 375                 380                 


Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe 
385                 390                 395                 400 


Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu 
                405                 410                 415     


Gly Ser Gly Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr 
            420                 425                 430         


Ile Arg Ala Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu 
        435                 440                 445             


Ser Gln Ala Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp 
    450                 455                 460                 


Ala Ser Asp Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 
465                 470                 475                 480 


Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 
                485                 490                 495     


Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly 
            500                 505                 510         


Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln 
        515                 520                 525             


Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys 
    530                 535                 540                 


Asp Arg Ala Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly 
545                 550                 555                 560 


Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 
                565                 570                 575     


Gly Arg Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 
            580                 585                 590         


Ile Gln Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 
        595                 600                 605             


Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 
    610                 615                 620                 


His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala 
625                 630                 635                 640 


Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu 
                645                 650                 655     


Asn Val Leu Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys 
            660                 665                 670         


Ala Phe Asp Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 
        675                 680                 685             


Ser Ala Ile Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val 
    690                 695                 700                 


Lys Arg Val Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 
705                 710                 715                 720 


Arg Glu Arg Leu 
                


<210>  117
<211>  767
<212>  PRT
<213>  artificial Sequence

<220>
<223>  PSD-95 isoform 2

<400>  117

Met Ser Gln Arg Pro Arg Ala Pro Arg Ser Ala Leu Trp Leu Leu Ala 
1               5                   10                  15      


Pro Pro Leu Leu Arg Trp Ala Pro Pro Leu Leu Thr Val Leu His Ser 
            20                  25                  30          


Asp Leu Phe Gln Ala Leu Leu Asp Ile Leu Asp Tyr Tyr Glu Ala Ser 
        35                  40                  45              


Leu Ser Glu Ser Gln Lys Tyr Arg Tyr Gln Asp Glu Asp Thr Pro Pro 
    50                  55                  60                  


Leu Glu His Ser Pro Ala His Leu Pro Asn Gln Ala Asn Ser Pro Pro 
65                  70                  75                  80  


Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro Gly Tyr Glu Leu Gln 
                85                  90                  95      


Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr Leu Glu 
            100                 105                 110         


Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr Asp Asn 
        115                 120                 125             


Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile Ile Pro 
    130                 135                 140                 


Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp Ser Ile 
145                 150                 155                 160 


Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser Ala Ala 
                165                 170                 175     


Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr Val Met 
            180                 185                 190         


Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu Ile Lys 
        195                 200                 205             


Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly Asn Gln 
    210                 215                 220                 


His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile Glu Gly 
225                 230                 235                 240 


Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys Ile Leu 
                245                 250                 255     


Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp Ala Val 
            260                 265                 270         


Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val Ala Lys 
        275                 280                 285             


Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp Ile Thr 
    290                 295                 300                 


Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser Ser Tyr 
305                 310                 315                 320 


Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro Arg Arg 
                325                 330                 335     


Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile Pro Arg 
            340                 345                 350         


Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu Gly Phe 
        355                 360                 365             


Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser Phe Ile 
    370                 375                 380                 


Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys Gly Asp 
385                 390                 395                 400 


Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser His Glu 
                405                 410                 415     


Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr Ile Ile 
            420                 425                 430         


Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys Ile His 
        435                 440                 445             


Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly Thr Ala 
    450                 455                 460                 


Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala Leu Phe 
465                 470                 475                 480 


Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala Leu Ser 
                485                 490                 495     


Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp Glu Glu 
            500                 505                 510         


Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp Asp Ile 
        515                 520                 525             


Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp Ser Arg 
    530                 535                 540                 


Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly Arg Glu 
545                 550                 555                 560 


Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val His Tyr 
                565                 570                 575     


Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala Asn Asp 
            580                 585                 590         


Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val Pro His 
        595                 600                 605             


Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp Tyr His 
    610                 615                 620                 


Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala His Lys 
625                 630                 635                 640 


Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr Ser Val 
                645                 650                 655     


Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile Leu Asp 
            660                 665                 670         


Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu His Pro 
        675                 680                 685             


Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu Glu Ile 
    690                 695                 700                 


Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp Arg Ala 
705                 710                 715                 720 


Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile Val Glu 
                725                 730                 735     


Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val Ile Glu 
            740                 745                 750         


Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg Leu 
        755                 760                 765         


<210>  118
<211>  720
<212>  PRT
<213>  artificial Sequence

<220>
<223>  PSD-95 isoform 3

<400>  118

Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 
1               5                   10                  15      


Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His Leu Pro Asn Gln 
            20                  25                  30          


Ala Asn Ser Pro Pro Val Ile Val Asn Thr Asp Thr Leu Glu Ala Pro 
        35                  40                  45              


Gly Tyr Val Asn Gly Thr Glu Gly Glu Met Glu Tyr Glu Glu Ile Thr 
    50                  55                  60                  


Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala Gly Gly Thr 
65                  70                  75                  80  


Asp Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile Thr Lys Ile 
                85                  90                  95      


Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg Val Asn Asp 
            100                 105                 110         


Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val Thr His Ser 
        115                 120                 125             


Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile Val Arg Leu Tyr 
    130                 135                 140                 


Val Met Arg Arg Lys Pro Pro Ala Glu Lys Val Met Glu Ile Lys Leu 
145                 150                 155                 160 


Ile Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala Gly Gly Val Gly 
                165                 170                 175     


Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val Thr Lys Ile Ile 
            180                 185                 190         


Glu Gly Gly Ala Ala His Lys Asp Gly Arg Leu Gln Ile Gly Asp Lys 
        195                 200                 205             


Ile Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met His Glu Asp 
    210                 215                 220                 


Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr Leu Lys Val 
225                 230                 235                 240 


Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala Pro Pro Asp 
                245                 250                 255     


Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn Glu Ile Ser His Ser 
            260                 265                 270         


Ser Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Met Thr Pro Thr Ser Pro 
        275                 280                 285             


Arg Arg Tyr Ser Pro Val Ala Lys Asp Leu Leu Gly Glu Glu Asp Ile 
    290                 295                 300                 


Pro Arg Glu Pro Arg Arg Ile Val Ile His Arg Gly Ser Thr Gly Leu 
305                 310                 315                 320 


Gly Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Ile Ser 
                325                 330                 335     


Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Lys 
            340                 345                 350         


Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg Asn Ala Ser 
        355                 360                 365             


His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln Thr Val Thr 
    370                 375                 380                 


Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser Arg Phe Glu Ala Lys 
385                 390                 395                 400 


Ile His Asp Leu Arg Glu Gln Leu Met Asn Ser Ser Leu Gly Ser Gly 
                405                 410                 415     


Thr Ala Ser Leu Arg Ser Asn Pro Lys Arg Gly Phe Tyr Ile Arg Ala 
            420                 425                 430         


Leu Phe Asp Tyr Asp Lys Thr Lys Asp Cys Gly Phe Leu Ser Gln Ala 
        435                 440                 445             


Leu Ser Phe Arg Phe Gly Asp Val Leu His Val Ile Asp Ala Ser Asp 
    450                 455                 460                 


Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser Glu Thr Asp 
465                 470                 475                 480 


Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg Arg Glu Trp 
                485                 490                 495     


Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser Gly Ser Gln Gly 
            500                 505                 510         


Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr Val Thr Gln Met Glu Val 
        515                 520                 525             


His Tyr Ala Arg Pro Ile Ile Ile Leu Gly Pro Thr Lys Asp Arg Ala 
    530                 535                 540                 


Asn Asp Asp Leu Leu Ser Glu Phe Pro Asp Lys Phe Gly Ser Cys Val 
545                 550                 555                 560 


Pro His Thr Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp Gly Arg Asp 
                565                 570                 575     


Tyr His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp Ile Gln Ala 
            580                 585                 590         


His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu Tyr Gly Thr 
        595                 600                 605             


Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys His Cys Ile 
    610                 615                 620                 


Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln Ala Ala His Leu 
625                 630                 635                 640 


His Pro Ile Ala Ile Phe Ile Arg Pro Arg Ser Leu Glu Asn Val Leu 
                645                 650                 655     


Glu Ile Asn Lys Arg Ile Thr Glu Glu Gln Ala Arg Lys Ala Phe Asp 
            660                 665                 670         


Arg Ala Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe Ser Ala Ile 
        675                 680                 685             


Val Glu Gly Asp Ser Phe Glu Glu Ile Tyr His Lys Val Lys Arg Val 
    690                 695                 700                 


Ile Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala Arg Glu Arg 
705                 710                 715                 720 


<210>  119
<211>  313
<212>  PRT
<213>  artificial Sequence

<220>
<223>  Synaptophysin isoform 1

<400>  119

Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210>  120
<211>  193
<212>  PRT
<213>  artificial Sequence

<220>
<223>  Synaptophysin isoform 2

<400>  120

Ala Leu Ala Thr Tyr Ile Phe Leu Gln Asn Lys Tyr Arg Glu Asn Asn 
1               5                   10                  15      


Lys Gly Pro Met Leu Asp Phe Leu Ala Thr Ala Val Phe Ala Phe Met 
            20                  25                  30          


Trp Leu Val Ser Ser Ser Ala Trp Ala Lys Gly Leu Ser Asp Val Lys 
        35                  40                  45              


Met Ala Thr Asp Pro Glu Asn Ile Ile Lys Glu Met Pro Val Cys Arg 
    50                  55                  60                  


Gln Thr Gly Asn Thr Cys Lys Glu Leu Arg Asp Pro Val Thr Ser Gly 
65                  70                  75                  80  


Leu Asn Thr Ser Val Val Phe Gly Phe Leu Asn Leu Val Leu Trp Val 
                85                  90                  95      


Gly Asn Leu Trp Phe Val Phe Lys Glu Thr Gly Trp Ala Ala Pro Phe 
            100                 105                 110         


Leu Arg Ala Pro Pro Gly Ala Pro Glu Lys Gln Pro Ala Pro Gly Asp 
        115                 120                 125             


Ala Tyr Gly Asp Ala Gly Tyr Gly Gln Gly Pro Gly Gly Tyr Gly Pro 
    130                 135                 140                 


Gln Asp Ser Tyr Gly Pro Gln Gly Gly Tyr Gln Pro Asp Tyr Gly Gln 
145                 150                 155                 160 


Pro Ala Gly Ser Gly Gly Ser Gly Tyr Gly Pro Gln Gly Asp Tyr Gly 
                165                 170                 175     


Gln Gln Gly Tyr Gly Pro Gln Gly Ala Pro Thr Ser Phe Ser Asn Gln 
            180                 185                 190         


Met 
    


<210>  121
<211>  277
<212>  PRT
<213>  artificial Sequence

<220>
<223>  Caspase-3

<400>  121

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  122
<211>  8873
<212>  DNA
<213>  artificial Sequence

<220>
<223>  pLenti-III-mir-GFP vector

<400>  122
ttttggattg aagccaatat gataatgagg gggtggagtt tgtgacgtgg cgcggggcgt       60

gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg atgttgcaag tgtggcggaa      120

cacatgtaag cgacggatgt ggcaaaagtg acgtttttgg tgtgcgccgg tgtacacagg      180

aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt aaatttgggc gtaaccgagt      240

aagatttggc cattttcgcg ggaaaactga ataagaggaa gtgaaatctg aataattttg      300

tgttactcat agcgcgtaat acggcagacc tcagcgctag attattgaag catttatcag      360

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg      420

gttccgcgca catttccccg aaaagtgcca cctgacgtta actataacgg tcctaaggta      480

gcgaaaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag      540

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      600

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      660

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacat aaacgggtct      720

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      780

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      840

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc      900

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc      960

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1020

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1080

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1140

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1200

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1260

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1320

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1380

aaagtaagac caccgcacag caagcccgct gatcttcaga cctggaggag gagatatgag     1440

ggacattgga gaagtgaatt atataaatat aaagtagtaa aaattgaacc attaggagta     1500

gcacccacca aggcaaagag aagagtggtg cagagagaaa aaagagcagt gggaatagga     1560

gctttgttcc ttgggttctt gggagcagca ggaagcacta tgggcgcagc gtcaatgacg     1620

ctgacggtac aggccagaca attattgtct ggtatagtgc agcagcagaa caatttgctg     1680

agggctattg aggcgcaaca gcatctgttg caactcacag tctggggcat caagcagctc     1740

caggcaagaa tcctggctgt ggaaagatac ctaaaggatc aacagctcct ggggatttgg     1800

ggttgctctg gaaaactcat ttgcaccact gctgtgcctt ggaatgctag ttggagtaat     1860

aaatctctgg aacagatttg gaatcacacg acctggatgg agtgggacag agaaattaac     1920

aattacacaa gcttaataca ctccttaatt gaagaatcgc aaaaccagca agaaaagaat     1980

gaacaagaat tattggaatt agataaatgg gcaagtttgt ggaattggtt taacataaca     2040

aattggctgt ggtatataaa attattcata atgatagtag gaggcttggt aggtttaaga     2100

atagtttttg ctgtactttc tatagtgaat agagttaggc agggatattc accattatcg     2160

tttcagaccc acctcccaac cccgagggga cccgacaggc ccgaaggaat agaagaagaa     2220

ggtggagaga gagacagaga cagatccatt cgattagtga acggatctcg acggtatcga     2280

aagcttggga ttcgaattta aaagaaaagg ggggattggg gggtacagtg caggggaaag     2340

aatagtagac ataatagcaa cagacataca aactaaagaa ctacaaaaac aaattacaaa     2400

aattcaaaat tttcgggttt ttcgaaccta gggttccgcg ttacataact tacggtaaat     2460

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt     2520

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa     2580

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc     2640

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct     2700

acttggcagt acatctacgt ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt     2760

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg     2820

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca     2880

actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca     2940

gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc     3000

atagaagaac cgagtttaaa ctccctatca gtgatagaga tctccctatc agtgatagag     3060

agctagaatc tagaggtacc gccaccatgg tgagcaaggg cgaggagctg ttcaccgggg     3120

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg     3180

gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg     3240

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct     3300

tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag     3360

gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg     3420

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca     3480

aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct     3540

atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca     3600

tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg     3660

gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc     3720

ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc     3780

tcggcatgga cgagctgtac aagtgaggta ccgatatcga attcatagct agccctgcag     3840

gtctagactc gaggtcatac acggctctcc tctctgcggc cgcagtcgag tacccatacg     3900

acgtcccaga ctacgcttga gtttaaacac gcgtggtgtg gaaagtcccc aggctcccca     3960

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     4020

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     4080

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     4140

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc ggcctctgag     4200

ctattccaga agtagtgagg aggctttttt ggaggccatg accgagtaca agcccacggt     4260

gcgcctcgcc acccgcgacg acgtccctcg ggccgtacgc accctcgccg ccgcgttcgc     4320

cgactacccc gccacgcgcc acaccgtgga cccggaccgc cacatcgagc gggtcaccga     4380

gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc ggcaaggtgt gggtcgcgga     4440

cgacggcgcc gcggtggcgg tctggaccac gccggagagc gtcgaagcgg gggcggtgtt     4500

cgccgagatc ggcccgcgca tggccgagtt gagcggttcc cggctggccg cgcagcaaca     4560

gatggaaggg ctcctggcgc cgcaccggcc caaggagccc gcgtggttcc tggccaccgt     4620

cggcgtctcg cccgaccacc agggcaaggg tctgggcagc gccgtcgtgc tccccggagt     4680

ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag acctccgcgc cccgcaacct     4740

ccccttctac gagcggctcg gcttcaccgt caccgccgac gtcgaggtgc ccgaaggacc     4800

gcgcacctgg tgcatgaccc gcaagcccgg tgcctgaacg cgttccggaa atcaacctct     4860

ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct     4920

atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat     4980

tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt     5040

caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat     5100

tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc     5160

ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga     5220

caattccgtg gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg cctgtgttgc     5280

cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga     5340

ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtctcg ccttcgccct     5400

cagacgagtc ggatctccct ttgggccgcc tccccgcctg tccggatgga agggctaatt     5460

cactcccaac gaatacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag     5520

atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc     5580

ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga     5640

tccctcagac ccttttagtc agtgtggaaa attctagcag tagtagttca tgtcatctta     5700

ttattcagta tttataactt gcaaagaaat gaatatcaga gagtgagagg aacttgttta     5760

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat     5820

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     5880

ggcatctatg tcgggtgcgg agaaagaggt aatgaaatgg cattatgggt attatgggtc     5940

tgcattaatg aatcggccaa cgatcccggt gtgaaatacc gcacagatgc gtaaggagaa     6000

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     6060

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     6120

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     6180

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     6240

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     6300

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     6360

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     6420

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     6480

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     6540

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     6600

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     6660

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     6720

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     6780

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     6840

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     6900

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     6960

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     7020

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     7080

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     7140

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     7200

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     7260

ttgttgaaaa aggatcttca cctagatcct tttcacgtag aaagccagtc cgcagaaacg     7320

gtgctgaccc cggatgaatg tcagctactg ggctatctgg acaagggaaa acgcaagcgc     7380

aaagagaaag caggtagctt gcagtgggct tacatggcga tagctagact gggcggtttt     7440

atggacagca agcgaaccgg aattgccagc tggggcgccc tctggtaagg ttgggaagcc     7500

ctgcaaagta aactggatgg ctttctcgcc gccaaggatc tgatggcgca ggggatcaag     7560

ctctgatcaa gagacaggat gaggatcgtt tcgcatgatt gaacaagatg gattgcacgc     7620

aggttctccg gccgcttggg tggagaggct attcggctat gactgggcac aacagacaat     7680

cggctgctct gatgccgccg tgttccggct gtcagcgcag gggcgcccgg ttctttttgt     7740

caagaccgac ctgtccggtg ccctgaatga actgcaagac gaggcagcgc ggctatcgtg     7800

gctggccacg acgggcgttc cttgcgcagc tgtgctcgac gttgtcactg aagcgggaag     7860

ggactggctg ctattgggcg aagtgccggg gcaggatctc ctgtcatctc accttgctcc     7920

tgccgagaaa gtatccatca tggctgatgc aatgcggcgg ctgcatacgc ttgatccggc     7980

tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag cgagcacgta ctcggatgga     8040

agccggtctt gtcgatcagg atgatctgga cgaagagcat caggggctcg cgccagccga     8100

actgttcgcc aggctcaagg cgagcatgcc cgacggcgag gatctcgtcg tgacccatgg     8160

cgatgcctgc ttgccgaata tcatggtgga aaatggccgc ttttctggat tcatcgactg     8220

tggccggctg ggtgtggcgg accgctatca ggacatagcg ttggctaccc gtgatattgc     8280

tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg ctttacggta tcgccgctcc     8340

cgattcgcag cgcatcgcct tctatcgcct tcttgacgag ttcttctgaa ttttgttaaa     8400

atttttgtta aatcagctca ttttttaacc aataggccga aatcggcaac atcccttata     8460

aatcaaaaga atagaccgcg atagggttga gtgttgttcc agtttggaac aagagtccac     8520

tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc     8580

cactacgtga accatcaccc aaatcaagtt ttttgcggtc gaggtgccgt aaagctctaa     8640

atcggaaccc taaagggagc ccccgattta gagcttgacg gggaaagccg gcgaacgtgg     8700

cgagaaagga agggaagaaa gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg     8760

tcacgctgcg cgtaaccacc acacccgcgc gcttaatgcg ccgctacagg gcgcgtccat     8820

tcgccattca ggatcgaatt aattcttaat taacatcatc aataatatac ctt            8873


